SEQUENCE LISTING


<110>  Compugen Ltd

<120>  IMMUNOMODULATORY ANTI-VSTM5 ANTIBODIES AND THE USE THEREOF IN THERAPY AND DIAGNOSIS 


<130>  

<160>  348

<210>  1
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 1

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      



<210>  2
<211>  119
<212>  PRT
<213>  Homo sapiens

<400> 2

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His 
        115                 



<210>  3
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 3

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp 
        115         



<210>  4
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400> 4

atgaggcctc tgcccagcgg gaggaggaag acccgaggca tctccctagg actcttcgcc     60

ctctgcctgg ccgcagcccg ctgtctgcag agtcagggtg tgtccctata cattcctcag    120

gccaccatca atgccactgt caaagaagac atcctgctct cagttgagta ctcctgtcat    180

ggagtgccca ccatcgaatg gacatattca tccaattggg gaacgcagaa gatcgtggag    240

tggaaaccag ggactcaggc caacatctct caaagccaca aggacagagt ctgcaccttt    300

gacaacggct ccatccagct cttcagcgtg ggagtgaggg attccggcta ctatgtcatc    360

accgtgacgg agcgcctggg gagcagccag tttggcacca tcgtgctgca cgtctctgag    420

atcctctatg aagacctgca ctttgtcgct gtcatccttg cttttctcgc tgctgtggcc    480

gcagtattaa tcagcctcat gtgggtttgt aataagtgtg catataaatt tcagaggaag    540

agaagacaca aactcaaaga aagcacaact gaggagattg agctggaaga tgttgagtgt    600

tagccaaggc tgggcctgac tgcattccta cctcaagagg aaaccattct ccaacaaaaa    660

gagcaagcac agctattata cccattgtgt gtggtcctgt tgcagcccgc tcctaacagg    720

acagtgggag attaacaaca ttgactgcat ggagttgagg actgtggatg ggacaaagct    780

agtattagga ctcgcgctaa gttcaaggag aagagtgatt gaggctttga accaggagct    840

tcgcttggct gcagcatcag ggccgtgctg acacataacc aatggcagtc ggaggaacca    900

ggctctgggc caggacagtt tccagtgctg tgaagaaacg aggtgagcag tatccaaggg    960

gctcaaggat aatctgctga tttctttctc gtctttcaca cagagaggcc accagcagga   1020

aagcagtggg agttgggtag ctgctggggc cagcatgtcc tcttccacac tacctgcctt   1080

tcagaactct gctcttccgc ttgtcccgaa gtcagggctg gcaatcttca taatcaaagg   1140

ggagttggaa aagaacaccc actaagaggc ctccatggca gatgtcaatt aaattgcccc   1200

cccccccaaa tctcatgaca gtttattcac atcagtagtg tgggaagtta caatgttttt   1260

tttaaaaaaa gcttctttcc ttggctttcc atttctttga aaaaagggtt tcttttgaat   1320

ttttaaagct ctgccatact gaacattcct gtggaaaggt ttaaaatgca gagcctgagg   1380

tttttgcttt tcagaaaaat aaaaatcata gagattagct agtgtaaatg ttaagctata   1440

aattatgttt caaactgtga aaaaaaaaag ttttaaagaa tgaatgaaat aaaacctgaa   1500

aataaagccc tggtcctttg                                               1520


<210>  5
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400> 5

atgaggcctc tgcccagcgg gaggaggaag acccgaggca tctccctagg actcttcgcc     60

ctctgcctgg ccgcagcccg ctgtctgcag agtcagggtg tgtccctata cattcctcag    120

gccaccatca atgccactgt caaagaagac atcctgctct cagttgagta ctcctgtcat    180

ggagtgccca ccatcgaatg gacatattca tccaattggg gaacgcagaa gatcgtggag    240

tggaaaccag ggactcaggc caacatctct caaagccaca aggacagagt ctgcaccttt    300

gacaacggct ccatccagct cttcagcgtg ggagtgaggg attccggcta ctatgtcatc    360

accgtgacgg agcgcctggg gagcagccag tttggcacca tcgtgctgca cgtctctgag    420

atcctctatg aagacctgca ctttgtcgct gtcatccttg cttttctcgc tgctgtggcc    480

gcagtattaa tcagcctcat gtgggtttgt aataagtgtg catataaatt tcagaggaag    540

agaagacaca aactcaaagg taaccccctg ggccttgtga taatccatga gtggttttga    600

ggccagaggt ggcatgtgtt atcttgttct cacgaagaaa gcactatgtg gcttgatttc    660

caactcattg acttgtcttt gctttacaga aagcacaact gaggagattg agctggaaga    720

tgttgagtgt tagccaaggc tgggcctgac tgcattccta cctcaagagg aaaccattct    780

ccaacaaaaa gagcaagcac agctattata cccattgtgt gtggtcctgt tgcagcccgc    840

tcctaacagg acagtgggag attaacaaca ttgactgcat ggagttgagg actgtggatg    900

ggacaaagct agtattagga ctcgcgctaa gttcaaggag aagagtgatt gaggctttga    960

accaggagct tcgcttggct gcagcatcag ggccgtgctg acacataacc aatggcagtc   1020

ggaggaacca ggctctgggc caggacagtt tccagtgctg tgaagaaacg aggtgagcag   1080

tatccaaggg gctcaaggat aatctgctga tttctttctc gtctttcaca cagagaggcc   1140

accagcagga aagcagtggg agttgggtag ctgctggggc cagcatgtcc tcttccacac   1200

tacctgcctt tcagaactct gctcttccgc ttgtcccgaa gtcagggctg gcaatcttca   1260

taatcaaagg ggagttggaa aagaacaccc actaagaggc ctccatggca gatgtcaatt   1320

aaattgcccc cccccccaaa tctcatgaca gtttattcac atcagtagtg tgggaagtta   1380

caatgttttt tttaaaaaaa gcttctttcc ttggctttcc atttctttga aaaaagggtt   1440

tcttttgaat ttttaaagct ctgccatact gaacattcct gtggaaaggt ttaaaatgca   1500

gagcctgagg tttttgcttt tcagaaaaat aaaaatcata gagattagct agtgtaaatg   1560

ttaagctata aattatgttt caaactgtga aaaaaaaaag ttttaaagaa tgaatgaaat   1620

aaaacctgaa aataaagccc tggtcctttg                                    1650


<210>  6
<211>  200
<212>  PRT
<213>  Homo sapiens

<400> 6

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr Glu Glu 
            180                 185                 190         


Ile Glu Leu Glu Asp Val Glu Cys 
        195                 200 



<210>  7
<211>  199
<212>  PRT
<213>  Homo sapiens

<400> 7

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Gly Asn Pro Leu Gly Leu 
            180                 185                 190         


Val Ile Ile His Glu Trp Phe 
        195                 



<210>  8
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc

<400> 8

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu 
            100                 105                 110         


Ile Arg Tyr Glu Asp Leu His Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    210                 215                 220                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         



<210>  9
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to EGFP

<400> 9

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr Glu Glu 
            180                 185                 190         


Ile Glu Leu Glu Asp Val Glu Cys Arg Ile Leu Gln Ser Thr Val Pro 
        195                 200                 205             


Arg Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
    210                 215                 220                 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
225                 230                 235                 240 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
                245                 250                 255     


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
            260                 265                 270         


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
        275                 280                 285             


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
    290                 295                 300                 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
305                 310                 315                 320 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
                325                 330                 335     


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
            340                 345                 350         


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
        355                 360                 365             


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
    370                 375                 380                 


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
385                 390                 395                 400 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
                405                 410                 415     


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
            420                 425                 430         


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
        435                 440                 445             


Leu Gly Met Asp Glu Leu Tyr Lys 
    450                 455     



<210>  10
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to mouse IgG2a Fc

<400> 10

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly Glu Pro Arg Gly 
145                 150                 155                 160 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                165                 170                 175     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            180                 185                 190         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        195                 200                 205             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    210                 215                 220                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
225                 230                 235                 240 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                245                 250                 255     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            260                 265                 270         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        275                 280                 285             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    290                 295                 300                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
305                 310                 315                 320 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                325                 330                 335     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            340                 345                 350         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        355                 360                 365             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    370                 375                 380                 


Arg Thr Pro Gly Lys 
385                 



<210>  11
<211>  199
<212>  PRT
<213>  Homo sapiens

<400> 11

Met Arg Pro Leu Arg Cys Gly Glu Arg Thr Gln Gly Ile Pro Leu Gly 
1               5                   10                  15      


Leu Leu Ala Phe Trp Val Thr Ala Ala Arg Cys Leu Gln Ser Gln Gly 
            20                  25                  30          


Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn Ala Thr Val Gln Gln 
        35                  40                  45              


Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His Gly Val Pro Thr Ile 
    50                  55                  60                  


Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln Arg Ile Val Glu Trp 
65                  70                  75                  80  


Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser His Arg Asp Arg Val 
                85                  90                  95      


Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Asn Val Ser Val Lys 
            100                 105                 110         


Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu His Pro Gly Ser Ser 
        115                 120                 125             


Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu Ile Arg Tyr Glu Asp 
    130                 135                 140                 


Leu His Phe Val Ala Val Phe Phe Ala Leu Leu Ala Ala Val Ala Val 
145                 150                 155                 160 


Val Leu Ile Ser Leu Met Trp Val Cys Asn Gln Cys Ala Tyr Lys Phe 
                165                 170                 175     


Gln Arg Lys Arg Arg Tyr Lys Leu Lys Glu Ser Thr Thr Glu Glu Ile 
            180                 185                 190         


Glu Met Lys Glu Val Glu Cys 
        195                 



<210>  12
<211>  18
<212>  PRT
<213>  Homo sapiens

<400> 12

Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val 
1               5                   10                  15      


Glu Trp 
        



<210>  13
<211>  19
<212>  PRT
<213>  Homo sapiens

<400> 13

Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val 
1               5                   10                  15      


Glu Trp Lys 
            



<210>  14
<211>  19
<212>  PRT
<213>  Homo sapiens

<400> 14

Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
1               5                   10                  15      


Val Glu Trp 
            



<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400> 15

Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
1               5                   10                  15      


Val Glu Trp Lys 
            20  



<210>  16
<211>  28
<212>  PRT
<213>  Homo sapiens

<400> 16

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr 
            20                  25              



<210>  17
<211>  23
<212>  PRT
<213>  Homo sapiens

<400> 17

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val 
            20              



<210>  18
<211>  27
<212>  PRT
<213>  Homo sapiens

<400> 18

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            20                  25          



<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400> 19

Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
1               5                   10          



<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400> 20

Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly 
1               5                   10                  15      


Val 
    



<210>  21
<211>  12
<212>  PRT
<213>  Homo sapiens

<400> 21

Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
1               5                   10          



<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 22

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105         



<210>  23
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 23

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105     



<210>  24
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 24

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105 



<210>  25
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 25

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105             



<210>  26
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 26

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105                 



<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 27

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105                 110 



<210>  28
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 28

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 110     



<210>  29
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 29

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         



<210>  30
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 30

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile 
    



<210>  31
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 31

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu 
        



<210>  32
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 32

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr 
        115 



<210>  33
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 33

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu 
        115     



<210>  34
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 34

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu 
        115             



<210>  35
<211>  120
<212>  PRT
<213>  Homo sapiens

<400> 35

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe 
        115                 120 



<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 36

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105         



<210>  37
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 37

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105             



<210>  38
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 38

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105                 



<210>  39
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 39

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 110 



<210>  40
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 40

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110     



<210>  41
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 41

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         



<210>  42
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 42

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu 
    



<210>  43
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 43

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr 
        



<210>  44
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 44

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu 
        115 



<210>  45
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 45

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp 
        115     



<210>  46
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 46

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu 
        115         



<210>  47
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 47

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu His 
        115             



<210>  48
<211>  119
<212>  PRT
<213>  Homo sapiens

<400> 48

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu His Phe 
        115                 



<210>  49
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 49

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105     



<210>  50
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 50

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105         



<210>  51
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 51

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105             



<210>  52
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 52

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 



<210>  53
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 53

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110 



<210>  54
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 54

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110     



<210>  55
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 55

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         



<210>  56
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 56

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr 
    



<210>  57
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 57

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu 
        



<210>  58
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 58

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp 
        115 



<210>  59
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 59

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu 
        115     



<210>  60
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 60

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu His 
        115         



<210>  61
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 61

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu His Phe 
        115             



<210>  62
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 62

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      



<210>  63
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 63

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu 
    



<210>  64
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 64

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His 
        



<210>  65
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 65

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His Val 
            



<210>  66
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 66

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His Val Ser 
            100 



<210>  67
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 67

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95  



<210>  68
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 68

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      



<210>  69
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 69

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His 
    



<210>  70
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 70

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His Val 
        



<210>  71
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 71

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His Val Ser 
            



<210>  72
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 72

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  



<210>  73
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 73

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95  



<210>  74
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 74

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      


Val 
    



<210>  75
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 75

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      


Val Ser 
        



<210>  76
<211>  93
<212>  PRT
<213>  Homo sapiens

<400> 76

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90              



<210>  77
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 77

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  



<210>  78
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 78

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95  



<210>  79
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 79

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95      



<210>  80
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 80

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95      


Ser 
    



<210>  81
<211>  92
<212>  PRT
<213>  Homo sapiens

<400> 81

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90          



<210>  82
<211>  93
<212>  PRT
<213>  Homo sapiens

<400> 82

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90              



<210>  83
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 83

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  



<210>  84
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 84

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95  



<210>  85
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 85

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
                85                  90                  95      



<210>  86
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 86

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His 
            100             



<210>  87
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 87

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val 
            100                 



<210>  88
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 88

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105 



<210>  89
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 89

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105     



<210>  90
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 90

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105         



<210>  91
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 91

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His 
            100         



<210>  92
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 92

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val 
            100             



<210>  93
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 93

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser 
            100                 



<210>  94
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 94

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105 



<210>  95
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 95

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105     



<210>  96
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 96

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His 
            100     



<210>  97
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 97

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val 
            100         



<210>  98
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 98

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser 
            100             



<210>  99
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 99

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser Glu 
            100                 



<210>  100
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 100

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105 



<210>  101
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 101

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His 
            100 



<210>  102
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 102

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val 
            100     



<210>  103
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 103

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser 
            100         



<210>  104
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 104

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser Glu 
            100             



<210>  105
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 105

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser Glu Ile 
            100                 



<210>  106
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 106

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His 
            



<210>  107
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 107

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val 
            100 



<210>  108
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 108

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser 
            100     



<210>  109
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 109

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser Glu 
            100         



<210>  110
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 110

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser Glu Ile 
            100             



<210>  111
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S

<400> 111

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 



<210>  112
<211>  233
<212>  PRT
<213>  Mus Musculus

<400> 112

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             



<210>  113
<211>  232
<212>  PRT
<213>  Homo sapiens

<400> 113

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  114
<211>  232
<212>  PRT
<213>  Homo sapiens

<400> 114

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  115
<211>  217
<212>  PRT
<213>  Homo sapiens

<400> 115

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         



<210>  116
<211>  217
<212>  PRT
<213>  Mus Musculus

<400> 116

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         



<210>  117
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 117

Gly Ser 
1       



<210>  118
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 118

Gly Ser Gly Ser 
1               



<210>  119
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 119

Ala Ser 
1       



<210>  120
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 120

Gly Gly Gly Ser 
1               



<210>  121
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 121

Gly Gly Gly Gly Ser 
1               5   



<210>  122
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 122

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  



<210>  123
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 123

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



<210>  124
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 124

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  



<210>  125
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 125

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Ala 
1               5                   10          



<210>  126
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 126

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    



<210>  127
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 127

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Gly Ala Ala Ala Lys Ala 
            20          



<210>  128
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 128

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Ala 
            20                  25          



<210>  129
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 129

Ala Gly Ala Ala Ala Lys Ala 
1               5           



<210>  130
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc

<400>  130

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210>  131
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to mouse IgG2a Fc

<400>  131

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly 
        115                 120                 125             


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
    130                 135                 140                 


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
145                 150                 155                 160 


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
            180                 185                 190         


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
        195                 200                 205             


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
    210                 215                 220                 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
225                 230                 235                 240 


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
                245                 250                 255     


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
            260                 265                 270         


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
        275                 280                 285             


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
    290                 295                 300                 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
305                 310                 315                 320 


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
                325                 330                 335     


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
            340                 345                 350         


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        355                 360     



<210>  132
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  132

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu 
        115                 120                 125             


Ala Ala Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys 
    130                 135                 140                 


Cys Ala Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser 
145                 150                 155                 160 


Thr Thr Glu Glu Ile Glu Leu Glu Asp Val Glu Cys 
                165                 170         



<210>  133
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to EGFP

<400>  133

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu 
        115                 120                 125             


Ala Ala Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys 
    130                 135                 140                 


Cys Ala Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser 
145                 150                 155                 160 


Thr Thr Glu Glu Ile Glu Leu Glu Asp Val Glu Cys Arg Ile Leu Gln 
                165                 170                 175     


Ser Thr Val Pro Arg Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser 
            180                 185                 190         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        195                 200                 205             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    210                 215                 220                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
225                 230                 235                 240 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                245                 250                 255     


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            260                 265                 270         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        275                 280                 285             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    290                 295                 300                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
305                 310                 315                 320 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                325                 330                 335     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            340                 345                 350         


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
        355                 360                 365             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    370                 375                 380                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
385                 390                 395                 400 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                405                 410                 415     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            420                 425             




<210>  134
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S

<400>  134

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Glu Pro Lys Ser Ser Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


Lys 
    



<210>  135
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S (G4S)x2 linker

<400>  135

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                245                 250                 255     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         



<210>  136
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc

<400>  136

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Glu Pro Arg Gly Pro Thr Ile 
            100                 105                 110         


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    130                 135                 140                 


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
145                 150                 155                 160 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                165                 170                 175     


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            180                 185                 190         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        195                 200                 205             


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
225                 230                 235                 240 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
                245                 250                 255     


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
            260                 265                 270         


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
    290                 295                 300                 


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
305                 310                 315                 320 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
                325                 330                 335     


Gly Lys 
        



<210>  137
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc (G4S)x2 linker

<400>  137

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
        115                 120                 125             


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
                165                 170                 175     


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
            180                 185                 190         


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
        195                 200                 205             


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
    210                 215                 220                 


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
225                 230                 235                 240 


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
                245                 250                 255     


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
            260                 265                 270         


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
        275                 280                 285             


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
305                 310                 315                 320 


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
                325                 330                 335     


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345             



<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  138

Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly 
1               5                   10      



<210>  139
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  139

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala His Glu Leu Ile 
1               5                   10                  15      


Cys Ala Leu Leu Ile Asn Lys Glu Arg 
            20                  25  



<210>  140
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  140

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          



<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  141

Gly Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Gly 
1               5                   10                  



<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  142

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            



<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  143

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      



<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  144

Gly Gly Gly Gly Ser Gly 
1               5       



<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  145

Gly Ser Gly Gly 
1               



<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  146

Gly Ser Gly Gly Ser 
1               5   


<210>  147
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc N297A


<400>  147

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu 
            100                 105                 110         


Ile Arg Tyr Glu Asp Leu His Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    210                 215                 220                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         



<210>  148
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc N297A

<400>  148

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             



<210>  149
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S N297A

<400>  149

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     



<210>  150
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 Fc C220S N297A


<400>  150

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  151
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  151

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr 
            100                 105 



<210>  152
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  152

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr 
            100                 



<210>  153
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  153

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr 
            100             



<210>  154
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  154

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 105     



<210>  155
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  155

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 105 



<210>  156
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  156

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 



<210>  157
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  157

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct    120

ccaggtaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatcag    300

tattccgtgg gagctactac ttatgactac tggggccagg gaaccctggt caccgtctct    360

tca                                                                  363


<210>  158
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  158

cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggagcctc ggtcaagctc     60

acctgcagtc tgagcagtgg gcacagcagc tacgccatcg catggcatca gcagcagcca    120

gagaagggcc ctcgatactt gatgaaactt aacagtgatg gcagccacag caagggggac    180

gggatccctg atcgcttctc aggctccagc tctggggctg agcgctacct caccatctcc    240

agcctccagt ctgaggatga ggctgactat tactgtcaga cctggggctc aggcattcag    300

gtgttcggcg gagggaccaa gctgaccgtc ctaggt                              336


<210>  159
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  159

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagtaagagg    300

gagctacatt cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  160
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  160

gatgttgtga tgactcagtc tccactctcc ctacccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctccta caaagtaatg gacacaacta tttgaattgg    120

tacctgcaga agccagggca gtctccacag gtcctgatct atttggcttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttgggatt tattactgca tgcaaggtct acaaattcct    300

ctcactttcg gcggagggac caaggtggaa atcaaacgt                           339


<210>  161
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  161

cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg     60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt    120

cagcccccag gaaaggccct ggagtggctt gcactcattt attgggatga tgataagcgc    180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg    240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacagt    300

ggttctgtcg gttacgctct ctactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  162
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  162

caggctgtgc tgactcagcc accttcctcc tccgcatctc ctggagaatc cgccagactc     60

acctgcacct tgcccagtga catcaatgtt cgttactaca acatatactg gtaccagcag    120

aagccaggga gccctcccag gtatctcctg tattaccagt cagactcaca taagggccgg    180

ggctctggag tccccagccg cttctctgga tccaaagata cttcagccaa tacagggatt    240

ttactcatct ccgggctcca gtctgaggat gaggctgact attactgtat gatttgggca    300

agcaatggtt ctggggtgct cggcggaggc acccagctga ccgtcctagg t             351


<210>  163
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  163

caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggacctc agtgaaggtt     60

tcctgcaagg cttctggata caccttcact acctatacta tgcattgggt gcgccaggcc    120

cccggacaaa ggcttgagtg gatgggatgg atcaacactg gcaatggtaa cacaaaatat    180

tcacagaagt tccaggacag agtcaccatt accagggaca catccgcgag cacagcctac    240

atggagctga gcagcctgaa atttgaagac acggctgtat attactgtgc gagagagggg    300

gttacgattt ttggagacca ctcctactac tacggtatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctca                                                  378


<210>  164
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  164

cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggatcctc ggtcaagctc     60

acctgcactc tgagcagtgg gcacagtagc tacatcatcg catggcatca gcagcagcca    120

gggaaggccc ctcgatactt gatgaagctt gaaggtagtg gaagctacaa caaggggagc    180

ggacttcctg atcgcttctc aggctccagc tctggggctg accgctacct caccatctcc    240

aacctccagt ctgaggatga ggctgattat tactgtgaga cctgggacgg taacacttgg    300

gtgttcggcg gaggcaccca gctgaccgtc ctaggt                              336


<210>  165
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  165

gaggtgcagc tggtggagtc tgggggaggt gtggtcaagc cgggggagtc cctgagactc     60

ttatgtacag cctctggatt gtccttcaat aaatacagca taaattgggt ccgccaggct    120

ccaggggggg ggcttgagtg ggtctcatcg attgaaagtg gtagtggaca tatatattac    180

gcagactcac tggagggccg cttcaccatc tccagagata acgccaagaa ctccgtgact    240

ctggaaatga acagcctgag agtcgaggac acggctcttt attactgtgt ctcggggccg    300

gaagacaagt ggttgttgca gctttacttt gagtcctggg gccagggaac cctggtcacc    360

gtctcctca                                                            369


<210>  166
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  166

gaaattgtgt tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca ggaccagtca gagttctccc agcgacaact tagcctggta tcagcacaaa    120

cctggccagg ctccgaggct cctcatctac ggtggttcca acagggccac tggcatccca    180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctagag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc    300

ggagggacca aagtggatat caaacgt                                        327


<210>  167
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  167

caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctggcga    300

ggtggtagct ttatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca          354


<210>  168
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  168

cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc     60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag    120

cacccaggca aagcccccaa actcatgatt tatgatgtca ttaagcggcc ctcaggggtc    180

cctgatcgct tctctggctc caggtctggc aacacggcct ccctgaccat ctctgggctc    240

caggctgaag atgaggctga ttattattgc tgctcatatg caggcaccca ttgggtgttc    300

ggcggaggga ccaagctcac cgtcctaggt                                     330


<210>  169
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  169

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgacctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagtt attagtggtg gtggtggtac cacatactac    180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cactctgtat    240

ctgcaaatga gcagcctgag agccgaggac acggccgtat attactgtgc gaaagggtat    300

agcagtggct ggccctacta ctttgactac tggggccagg gaaccctggt caccgtctcc    360

tca                                                                  363


<210>  170
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  170

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtggcgtc accaatttct tagcctggta tcagcagaaa    120

cctggccagg ctcccaggct cctcatctat gctacttcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgc gtctgggaca gacttcactc tcaccatcac cagactggag    240

cctgaagatt ttgcagttta tttctgccag caatatgctt cctcaccgct cactttcggc    300

ggagggacca aagtggagat caaacgt                                        327


<210>  171
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  171

caggtgcagc tggtgcaatc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cgactttaat aattactgga tcggctgggt gcgccagacg    120

cccgagaagg gcctggagtg gatggggatc gtctatcctg gtgaccatcc tggtgactat    180

catatcagat atggcccgtc cttccaaggc caggtcacca tctcagccga caggtccatc    240

accaccgcct acctacagtg gagaaacctg aaggcctcgg acaccgccat gtattactgt    300

gcgagactag gaagcagtaa agaccttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  172
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  172

gaaattgtgt tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc ggacacttag actggtacca acagaaacct    120

ggccagtctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttctctctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcac cgtagcaact ggccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa acgt                                           324


<210>  173
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  173

caggtgcagc tgcaggagtc gggcccagga ctgatgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtga ctccatcacc agaggtagca gttactggag ttggatccgg    120

cagtccgacg ggaagggact ggagtggatt gggcacatct atagtggagg ggacaccgac    180

tacaatcccg ccctcaagag tcgagtcact atatcagctg acgcgtccag gggccagttt    240

ttgttgagat tgacctcaat gaccgccgca gacacggccg tttattactg tgcgagagat    300

cgtggagcat acggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca       357


<210>  174
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  174

cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggagcctc ggtcaagctc     60

acctgcactc tgagcagtga acacgacaga tatgccatcg catggcttca acagaagcca    120

gagaagggtc ctcgctactt gatgaaggtt aacagtgatg gcagccacag gaagggggac    180

gggatccctg atcgcttctc aggctccagt tctggggctg agcgctacct caccatctcc    240

agactccagt ctgaggatga ggctgactat tactgtcaga cctggggcat tggcattagg    300

gtgttcggcg gtggcaccca gctgaccgtc ctaggt                              336


<210>  175
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  175

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc ccgcagactc     60

tcctgtgcag cgtctggatt cgccttccgt aattatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcattc atatcacaaa acggaggtaa gaaatattat    180

gcagactccg tgacgggccg attcaccgtc tccagagaca attccaagaa cacgttgtat    240

ctgcaaataa acagcctgac aactgacgac acggctgtgt tttactgtgc gaggtcgggg    300

agcgggtcat ggggctacag tgacttcccc ggaccctttg accactgggg ccagggatcc    360

ctggtcactg tctcctca                                                  378


<210>  176
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  176

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gaatattttc atcagcttct tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcctctat ggtgcttcca acagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctccccgct cactttcggc    300

ggagggacca aagtggagat caaacgt                                        327


<210>  177
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  177

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cttgaaactc     60

tcctgtgtag cctctggatt cacctttagc gcctatgcca tgaactgggt ccgcctggtt    120

ccaggtaagg ggctggagtg ggtctcaggt attagtggca atggctattc cacattctac    180

ccagactccg tgcagggccg attcaccgtc tccagagaca attccaagaa cacgttgttt    240

ctgcaaattg ataggctgac aggcggggac acggccatat actactgtgc gaaggtacag    300

actacggtta ttactccttt tcaaaactgg ggccagggaa ccctggtcac cgtctcttca    360


<210>  178
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  178

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gaatattggc agcaacttct tagcctggta ccagcaaaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcgtcca ccagggccaa tggcatccca    180

gacaggttca gtggcagtaa gtctgagaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatgata actcaccgta cacttttggc    300

caggggacca agctggagat caaacgt                                        327


<210>  179
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody heavy chain

<400>  179

gaggtgcagc tggtggagat tggaggaggc ttgatccagc ctgggaggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcggtt atatcatatg atggaagcaa aaaatactac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgcat    240

ctgcaaatga acagcctgag agtcgaggat acggctgtct attactgtgc gctcttgtcc    300

cgtccacact acggtttgga cgtctggggc caagggacca cggtcaccgt ctcctca       357


<210>  180
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody light chain

<400>  180

cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc     60

tcctgctctg gaagtcgctc caacgttggg ggtaattttc tttcctggta ccaacacgtc    120

ccaggaacac ccccccaact cctcatttat gacaattata agcgaccctc agagatacct    180

gaccgattct cgggctccaa gtctggcacg tcagccaccc tggacatcac cggactccag    240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag ttcttgggtg    300

ttcggcggag gcacccagct gaccgtccta ggt                                 333


<210>  181
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  181

ggattcacct tcagtagcta tgct                                            24


<210>  182
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  182

atatcatatg atggaagtaa taaa                                            24


<210>  183
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  183

gcgaaagatc agtattccgt gggagctact acttatgact ac                        42


<210>  184
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  184

agtgggcaca gcagctacgc c                                               21


<210>  185
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  185

cttaacagtg atggcagcca c                                               21


<210>  186
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  186

cagacctggg gctcaggcat tcaggtg                                         27


<210>  187
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  187

ggattcacct tcagtagcta tgct                                            24


<210>  188
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  188

atatcatatg atggaagcaa taaa                                            24


<210>  189
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  189

gcgagtaaga gggagctaca ttcctttgac tac                                  33


<210>  190
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  190

cagagcctcc tacaaagtaa tggacacaac tat                                  33


<210>  191
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  191

ttggcttct                                                              9


<210>  192
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  192

atgcaaggtc tacaaattcc tctcact                                         27


<210>  193
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  193

gggttctcac tcagcactag tggagtgggt                                      30


<210>  194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  194

atttattggg atgatgataa g                                               21


<210>  195
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  195

gcacacagtg gttctgtcgg ttacgctctc tactttgact ac                        42


<210>  196
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  196

agtgacatca atgttcgtta ctacaac                                         27


<210>  197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  197

taccagtcag actcacataa g                                               21


<210>  198
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  198

atgatttggg caagcaatgg ttctggggtg                                      30


<210>  199
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  199

ggatacacct tcactaccta tact                                            24


<210>  200
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  200

atcaacactg gcaatggtaa caca                                            24


<210>  201
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  201

gcgagagagg gggttacgat ttttggagac cactcctact actacggtat ggacgtc        57


<210>  202
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  202

agtgggcaca gtagctacat c                                               21


<210>  203
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  203

cttgaaggta gtggaagcta c                                               21


<210>  204
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  204

gagacctggg acggtaacac ttgggtg                                         27


<210>  205
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  205

ggattgtcct tcaataaata cagc                                            24


<210>  206
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  206

attgaaagtg gtagtggaca tata                                            24


<210>  207
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  207

gtctcggggc cggaagacaa gtggttgttg cagctttact ttgagtcc                  48


<210>  208
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  208

cagagttctc ccagcgacaa c                                               21


<210>  209
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  209

ggtggttcc                                                              9


<210>  210
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  210

cagcagtatg gtagctcacc gctcact                                         27


<210>  211
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  211

ggtgggtcct tcagtggtta ctac                                            24


<210>  212
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  212

atcaatcata gtggaagcac c                                               21


<210>  213
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  213

gcgagaggct ggcgaggtgg tagctttatg gacgtc                               36


<210>  214
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  214

agcagtgatg ttggtggtta taactat                                         27


<210>  215
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  215

gatgtcatt                                                              9


<210>  216
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  216

tgctcatatg caggcaccca ttgggtg                                         27


<210>  217
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  217

ggattcacct ttagcagcta tgcc                                            24


<210>  218
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  218

attagtggtg gtggtggtac caca                                            24


<210>  219
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  219

gcgaaagggt atagcagtgg ctggccctac tactttgact ac                        42


<210>  220
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  220

cagagtggcg tcaccaattt c                                               21


<210>  221
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  221

gctacttcc                                                              9


<210>  222
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  222

cagcaatatg cttcctcacc gctcact                                         27


<210>  223
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  223

ggatacgact ttaataatta ctgg                                            24


<210>  224
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  224

gtctatcctg gtgaccatcc tggt                                            24


<210>  225
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  225

atgtattact gtgcgagact aggaagcagt aaagaccttg actac                     45


<210>  226
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  226

cagagtgtta gcggacac                                                   18


<210>  227
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  227

gatgcatcc                                                              9


<210>  228
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  228

cagcaccgta gcaactggcc gtggacg                                         27


<210>  229
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  229

ggtgactcca tcaccagagg tagcagttac                                      30


<210>  230
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  230

atctatagtg gaggggacac c                                               21


<210>  231
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  231

gcgagagatc gtggagcata cggtatggac gtc                                  33


<210>  232
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  232

agtgaacacg acagatatgc c                                               21


<210>  233
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  233

gttaacagtg atggcagcca c                                               21


<210>  234
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  234

cagacctggg gcattggcat tagggtg                                         27


<210>  235
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  235

ggattcgcct tccgtaatta tggc                                            24


<210>  236
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  236

atatcacaaa acggaggtaa gaaa                                            24


<210>  237
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  237

gcgaggtcgg ggagcgggtc atggggctac agtgacttcc ccggaccctt tgaccac        57


<210>  238
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  238

cagaatattt tcatcagctt c                                               21


<210>  239
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  239

ggtgcttcc                                                              9


<210>  240
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  240

cagcagtatg gtagctcccc gctcact                                         27


<210>  241
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  241

ggattcacct ttagcgccta tgcc                                            24


<210>  242
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  242

attagtggca atggctattc caca                                            24


<210>  243
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  243

gcgaaggtac agactacggt tattactcct tttcaaaac                            39


<210>  244
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  244

cagaatattg gcagcaactt c                                               21


<210>  245
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  245

ggtgcgtcc                                                              9


<210>  246
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  246

cagcagtatg ataactcacc gtacact                                         27


<210>  247
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  247

ggattcacct tcagtagcta tgct                                            24


<210>  248
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  248

atatcatatg atggaagcaa aaaa                                            24


<210>  249
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  249

gcgctcttgt cccgtccaca ctacggtttg gacgtc                               36


<210>  250
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  250

cgctccaacg ttgggggtaa tttt                                            24


<210>  251
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  251

gacaattat                                                              9


<210>  252
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide antibody CDR

<400>  252

ggaacatggg atagcagcct gagttcttgg gtg                                  33


<210>  253
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Tyr Ser Val Gly Ala Thr Thr Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     



<210>  254
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  254

Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Ser Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Ser Gly Ile Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210>  255
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Lys Arg Glu Leu His Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             



<210>  256
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  256

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln Ser 
            20                  25                  30          


Asn Gly His Asn Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Ile Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    



<210>  257
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  257

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ser Gly Ser Val Gly Tyr Ala Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         



<210>  258
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  258

Gln Ala Val Leu Thr Gln Pro Pro Ser Ser Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ala Arg Leu Thr Cys Thr Leu Pro Ser Asp Ile Asn Val Arg Tyr 
            20                  25                  30          


Tyr Asn Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr 
        35                  40                  45              


Leu Leu Tyr Tyr Gln Ser Asp Ser His Lys Gly Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Thr Ser Ala Asn Thr Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp Ala Ser Asn Gly Ser Gly Val Leu Gly Gly Gly Thr Gln 
            100                 105                 110         


Leu Thr Val Leu Gly 
        115         



<210>  259
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  259

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Thr Ile Phe Gly Asp His Ser Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     



<210>  260
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  260

Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ile 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Glu Gly Ser Gly Ser Tyr Asn Lys Gly Ser Gly Leu Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Asn Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp 
                85                  90                  95      


Gly Asn Thr Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         



<210>  261
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  261

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Leu Cys Thr Ala Ser Gly Leu Ser Phe Asn Lys Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Glu Ser Gly Ser Gly His Ile Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Thr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Pro Glu Asp Lys Trp Leu Leu Gln Leu Tyr Phe Glu Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             



<210>  262
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  262

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Ser Pro Ser Asp 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Gly Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105                 



<210>  263
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  263

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Trp Arg Gly Gly Ser Phe Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             



<210>  264
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  264

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ile Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 



<210>  265
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Ser Ser Gly Trp Pro Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     



<210>  266
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  266

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Val Thr Asn 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ala Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 



<210>  267
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  267

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe Asn Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Val Tyr Pro Gly Asp His Pro Gly Asp Tyr His Ile Arg Tyr 
    50                  55                  60                  


Gly Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Arg Ser Ile 
65                  70                  75                  80  


Thr Thr Ala Tyr Leu Gln Trp Arg Asn Leu Lys Ala Ser Asp Thr Ala 
                85                  90                  95      


Met Tyr Tyr Cys Ala Arg Leu Gly Ser Ser Lys Asp Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         



<210>  268
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  268

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly His 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             



<210>  269
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  269

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Arg Gly 
            20                  25                  30          


Ser Ser Tyr Trp Ser Trp Ile Arg Gln Ser Asp Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Ser Gly Gly Asp Thr Asp Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Ala Ser Arg Gly Gln Phe 
65                  70                  75                  80  


Leu Leu Arg Leu Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Ala Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 



<210>  270
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  270

Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Glu His Asp Arg Tyr Ala 
            20                  25                  30          


Ile Ala Trp Leu Gln Gln Lys Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Asn Ser Asp Gly Ser His Arg Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Ile Gly Ile Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         



<210>  271
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  271

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Gln Asn Gly Gly Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Gly Ser Trp Gly Tyr Ser Asp Phe Pro Gly Pro 
            100                 105                 110         


Phe Asp His Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 125     



<210>  272
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  272

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Phe Ile Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Leu Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 



<210>  273
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  273

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Leu Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Asn Gly Tyr Ser Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Ile Asp Arg Leu Thr Gly Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gln Thr Thr Val Ile Thr Pro Phe Gln Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 



<210>  274
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  274

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Ser Asn 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Asn Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 



<210>  275
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody heavy chain

<400>  275

Glu Val Gln Leu Val Glu Ile Gly Gly Gly Leu Ile Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Leu Ser Arg Pro His Tyr Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 



<210>  276
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody light chain

<400>  276

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Val Gly Gly Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln His Val Pro Gly Thr Pro Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Tyr Lys Arg Pro Ser Glu Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ser Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110     



<210>  277
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  277

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               



<210>  278
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  278

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               



<210>  279
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  279

Ala Lys Asp Gln Tyr Ser Val Gly Ala Thr Thr Tyr Asp Tyr 
1               5                   10                  



<210>  280
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  280

Ser Gly His Ser Ser Tyr Ala 
1               5           



<210>  281
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  281

Leu Asn Ser Asp Gly Ser His 
1               5           



<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  282

Gln Thr Trp Gly Ser Gly Ile Gln Val 
1               5                   



<210>  283
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  283

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               



<210>  284
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  284

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               



<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  285

Ala Ser Lys Arg Glu Leu His Ser Phe Asp Tyr 
1               5                   10      



<210>  286
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  286

Gln Ser Leu Leu Gln Ser Asn Gly His Asn Tyr 
1               5                   10      



<210>  287
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  287

Leu Ala Ser 
1           



<210>  288
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  288

Met Gln Gly Leu Gln Ile Pro Leu Thr 
1               5                   



<210>  289
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  289

Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 
1               5                   10  



<210>  290
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  290

Ile Tyr Trp Asp Asp Asp Lys 
1               5           



<210>  291
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  291

Ala His Ser Gly Ser Val Gly Tyr Ala Leu Tyr Phe Asp Tyr 
1               5                   10                  



<210>  292
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  292

Ser Asp Ile Asn Val Arg Tyr Tyr Asn 
1               5                   



<210>  293
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  293

Tyr Gln Ser Asp Ser His Lys 
1               5           



<210>  294
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  294

Met Ile Trp Ala Ser Asn Gly Ser Gly Val 
1               5                   10  



<210>  295
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  295

Gly Tyr Thr Phe Thr Thr Tyr Thr 
1               5               



<210>  296
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR


<400>  296

Ile Asn Thr Gly Asn Gly Asn Thr 
1               5 



<210>  297
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  297

Ala Arg Glu Gly Val Thr Ile Phe Gly Asp His Ser Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            



<210>  298
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  298

Ser Gly His Ser Ser Tyr Ile 
1               5           



<210>  299
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  299

Leu Glu Gly Ser Gly Ser Tyr 
1               5           



<210>  300
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  300

Glu Thr Trp Asp Gly Asn Thr Trp Val 
1               5                   



<210>  301
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  301

Gly Leu Ser Phe Asn Lys Tyr Ser 
1               5               



<210>  302
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  302

Ile Glu Ser Gly Ser Gly His Ile 
1               5               



<210>  303
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  303

Val Ser Gly Pro Glu Asp Lys Trp Leu Leu Gln Leu Tyr Phe Glu Ser 
1               5                   10                  15      



<210>  304
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  304

Gln Ser Ser Pro Ser Asp Asn 
1               5           



<210>  305
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  305

Gly Gly Ser 
1           



<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  306

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   



<210>  307
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  307

Gly Gly Ser Phe Ser Gly Tyr Tyr 
1               5               



<210>  308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  308

Ile Asn His Ser Gly Ser Thr 
1               5           



<210>  309
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  309

Ala Arg Gly Trp Arg Gly Gly Ser Phe Met Asp Val 
1               5                   10          



<210>  310
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  310

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   



<210>  311
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  311

Asp Val Ile 
1           



<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  312

Cys Ser Tyr Ala Gly Thr His Trp Val 
1               5                   



<210>  313
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  313

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               



<210>  314
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  314

Ile Ser Gly Gly Gly Gly Thr Thr 
1               5               



<210>  315
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  315

Ala Lys Gly Tyr Ser Ser Gly Trp Pro Tyr Tyr Phe Asp Tyr 
1               5                   10                  



<210>  316
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  316

Gln Ser Gly Val Thr Asn Phe 
1               5           



<210>  317
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  317

Ala Thr Ser 
1           



<210>  318
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  318

Gln Gln Tyr Ala Ser Ser Pro Leu Thr 
1               5                   



<210>  319
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  319

Gly Tyr Asp Phe Asn Asn Tyr Trp 
1               5               



<210>  320
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  320

Val Tyr Pro Gly Asp His Pro Gly Asp Tyr His Ile 
1               5                   10          



<210>  321
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  321

Ala Arg Leu Gly Ser Ser Lys Asp Leu Asp Tyr 
1               5                   10      



<210>  322
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  322

Gln Ser Val Ser Gly His 
1               5       



<210>  323
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  323

Asp Ala Ser 
1           



<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  324

Gln His Arg Ser Asn Trp Pro Trp Thr 
1               5                   



<210>  325
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  325

Gly Asp Ser Ile Thr Arg Gly Ser Ser Tyr 
1               5                   10  



<210>  326
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  326

Ile Tyr Ser Gly Gly Asp Thr 
1               5           



<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  327

Ala Arg Asp Arg Gly Ala Tyr Gly Met Asp Val 
1               5                   10      



<210>  328
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  328

Ser Glu His Asp Arg Tyr Ala 
1               5           



<210>  329
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  329

Val Asn Ser Asp Gly Ser His 
1               5           



<210>  330
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  330

Gln Thr Trp Gly Ile Gly Ile Arg Val 
1               5                   



<210>  331
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  331

Gly Phe Ala Phe Arg Asn Tyr Gly 
1               5               



<210>  332
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  332

Ile Ser Gln Asn Gly Gly Lys Lys 
1               5               



<210>  333
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  333

Ala Arg Ser Gly Ser Gly Ser Trp Gly Tyr Ser Asp Phe Pro Gly Pro 
1               5                   10                  15      


Phe Asp His 
            



<210>  334
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  334

Gln Asn Ile Phe Ile Ser Phe 
1               5           



<210>  335
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  335

Gly Ala Ser 
1           



<210>  336
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  336

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   



<210>  337
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  337

Gly Phe Thr Phe Ser Ala Tyr Ala 
1               5               



<210>  338
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  338

Ile Ser Gly Asn Gly Tyr Ser Thr 
1               5               



<210>  339
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  339

Ala Lys Val Gln Thr Thr Val Ile Thr Pro Phe Gln Asn 
1               5                   10              



<210>  340
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  340

Gln Asn Ile Gly Ser Asn Phe 
1               5           



<210>  341
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  341

Gly Ala Ser 
1           



<210>  342
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  342

Gln Gln Tyr Asp Asn Ser Pro Tyr Thr 
1               5                   



<210>  343
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  343

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               



<210>  344
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  344

Ile Ser Tyr Asp Gly Ser Lys Lys 
1               5               



<210>  345
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  345

Ala Leu Leu Ser Arg Pro His Tyr Gly Leu Asp Val 
1               5                   10          



<210>  346
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  346

Arg Ser Asn Val Gly Gly Asn Phe 
1               5               



<210>  347
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  347

Asp Asn Tyr 
1           



<210>  348
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide antibody CDR

<400>  348

Gly Thr Trp Asp Ser Ser Leu Ser Ser Trp Val 
1               5                   10      



<210>  349
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  349

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu 
        115                 120                 125             


Ala Ala Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys 
    130                 135                 140                 


Cys Ala Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Gly Asn 
145                 150                 155                 160 


Pro Leu Gly Leu Val Ile Ile His Glu Trp Phe 
                165                 170     







