﻿               SEQUENCE LISTING

<110> Helmholtz Zentrum München - Deutsches Forschungszentrum für
      Gesundheit und Umwelt (GmbH) et al.         

<120> Novel means and methods for treating HBV infection and associated conditions

<130> W2662 PCT

<150> EP 13 18 4635.4  
<151> 2013-09-16

<160> 49

<170> BiSSAP 1.2

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv C8 heavy chain

<400> 1
Gly Phe Thr Phe Ser Gly Tyr Ala 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv C8 heavy chain

<400> 2
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210> 3
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv C8 heavy chain

<400> 3
Ala Lys Pro Pro Gly Arg Gln Glu Tyr Tyr Gly Ser Ser Ile Tyr Tyr 
1               5                   10                  15      
Phe Pro Leu Gly Asn 
            20      

<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv C8 light chain

<400> 4
Asn Ile Gly Ser Lys Ser 
1               5       

<210> 5
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv C8 light chain

<400> 5
Asp Asp Ser 
1

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv C8 light chain

<400> 6
Gln Val Trp Asp Ser Ser Ser Asp Leu Val Val 
1               5                   10      

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 5F9 heavy chain

<400> 7
Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 5F9 heavy chain

<400> 8
Ile Asn Ser Asp Gly Arg Ser Thr 
1               5               

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 5F9 heavy chain

<400> 9
Ala Arg Thr Phe Tyr Ala Asp Tyr 
1               5               

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 5F9 light chain

<400> 10
Gln Asn Val Asp Thr Thr 
1               5       

<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 5F9 light chain

<400> 11
Trp Ala Ser 
1       

<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 5F9 light chain

<400> 12
Gln Gln Tyr Ser Ile Phe Pro Tyr Thr 
1               5                   

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 5A19 heavy chain

<400> 13
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 5A19 heavy chain

<400> 14
Val Ser Ser Asp Gly Ser Tyr Ala 
1               5               

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 5A19 heavy chain

<400> 15
Ala Ser Phe Asn Trp Asp Val Ala Tyr 
1               5                   

<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 5A19 light chain

<400> 16
Gln Ser Leu Leu Asn Thr Arg Thr Arg Lys Ser Tyr 
1               5                   10          

<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 5A19 light chain

<400> 17
Trp Ala Ser 
1    

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 5A19 light chain

<400> 18
Lys Gln Ser Tyr Ser Leu Tyr Thr 
1               5               

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv OKT3 heavy chain

<400> 19
Gly Tyr Thr Phe Thr Arg Tyr Thr 
1               5               

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv OKT3 heavy chain

<400> 20
Ile Asn Pro Ser Arg Gly Tyr Thr 
1               5               

<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv OKT3 heavy chain

<400> 21
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10          

<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv OKT3 light chain

<400> 22
Ser Ser Val Ser Tyr 
1               5   

<210> 23
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv OKT3 light chain

<400> 23
Asp Thr Ser 
1 


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv OKT3 light chain

<400> 24
Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   

<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 9.3 heavy chain

<400> 25
Gly Phe Ser Leu Ser Asp Tyr Gly 
1               5               

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 9.3 heavy chain

<400> 26
Ile Trp Ala Gly Gly Gly Thr 
1               5           

<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 9.3 heavy chain

<400> 27
Ala Arg Asp Lys Gly Tyr Ser Tyr Tyr Tyr Ser Met Asp Tyr 
1               5                   10                  

<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv 9.3 light chain

<400> 28
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 
1               5                   10  

<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv 9.3 light chain

<400> 29
Ala Ala Ser 
1 

<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv 9.3 light chain

<400> 30
Gln Gln Ser Arg Lys Val Pro Tyr Thr 
1               5                   

<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv A9 heavy chain

<400> 31
Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               

<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv A9 heavy chain

<400> 32
Ile Tyr Pro Gly Gly Gly Tyr Thr 
1               5               

<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv A9 heavy chain

<400> 33
Ala Arg Ser Ala Ser Trp Tyr Phe Asp Val 
1               5                   10  

<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv A9 light chain

<400> 34
Thr Gly Thr Val Thr Thr Ser Asn Tyr 
1               5 

<210> 35
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv A9 light chain

<400> 35
His Thr Asn 
1                   

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv A9 light chain

<400> 36
Ala Leu Trp Tyr Asn Asn His Trp Val 
1               5                   

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv NCAM29.2 heavy chain

<400> 37
Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv NCAM29.2 heavy chain

<400> 38
Ile Ser Ser Gly Ser Tyr Ala Ile 
1               5               

<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv NCAM29.2 heavy chain

<400> 39
Val Arg Gly Arg Arg Leu Gly Glu Gly Tyr Ala Met Asp Tyr 
1               5                   10      
       
<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of scFv NCAM29.2 light chain

<400> 40
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10

<210> 41
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of scFv NCAM29.2 light chain

<400> 41
Trp Ala Ser 
1          

<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of scFv NCAM29.2 light chain

<400> 42
Gln Gln Tyr Ser Ser Trp Thr 
1               5           

<210> 43
<211> 794
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-HBsAg scFv [C8]^Glycin-Serin-Linker^hIgG1-Fc[C245S,L259F,L26
      0E,G262A,A355T]^StrepTag^Glycin-Linker^anti-CD3 scFv [OKT3]

<400> 43
Met Asp Phe Glu Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Met Ser Arg Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          
Gly Leu Leu Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              
Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  
Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser 
65                  70                  75                  80  
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         
Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Pro Pro Gly Arg Gln Glu Tyr 
        115                 120                 125             
Tyr Gly Ser Ser Ile Tyr Tyr Phe Pro Leu Gly Asn Trp Gly Gln Gly 
    130                 135                 140                 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys Leu Glu 
145                 150                 155                 160 
Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Ala Leu Thr Gln Pro 
                165                 170                 175     
Ala Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
            180                 185                 190         
Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
    210                 215                 220                 
Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
225                 230                 235                 240 
Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
                245                 250                 255     
Gln Val Trp Asp Ser Ser Ser Asp Leu Val Val Phe Gly Gly Gly Thr 
            260                 265                 270         
Lys Leu Thr Val Leu Gly Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys 
    290                 295                 300                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Ala Pro 
305                 310                 315                 320 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            340                 345                 350         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile Glu Lys 
                405                 410                 415     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                485                 490                 495     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        515                 520                 525             
Lys Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Arg Gly Gly 
    530                 535                 540                 
Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
545                 550                 555                 560 
Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                565                 570                 575     
Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
            580                 585                 590         
Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
        595                 600                 605             
Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
    610                 615                 620                 
Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
625                 630                 635                 640 
Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
                645                 650                 655     
Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Asn Ser Gly Gly Gly Gly 
            660                 665                 670         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Gln Ile Val 
        675                 680                 685             
Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
    690                 695                 700                 
Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
705                 710                 715                 720 
Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
                725                 730                 735     
Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly 
            740                 745                 750         
Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala 
        755                 760                 765             
Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
    770                 775                 780                 
Gly Thr Lys Leu Glu Ile Asn Gly Asn Ser 
785                 790                 

<210> 44
<211> 793
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-HBsAg scFv [C8]^Glycin-Serin-Linker^hIgG1-Fc[C245S,L259F,L26
      0E,G262A,A355T]^StrepTag^Glycin-Linker^ anti-CD28 scFv [9.3]

<400> 44
Met Asp Phe Glu Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Met Ser Arg Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          
Gly Leu Leu Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              
Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  
Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser 
65                  70                  75                  80  
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         
Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Pro Pro Gly Arg Gln Glu Tyr 
        115                 120                 125             
Tyr Gly Ser Ser Ile Tyr Tyr Phe Pro Leu Gly Asn Trp Gly Gln Gly 
    130                 135                 140                 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys Leu Glu 
145                 150                 155                 160 
Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Ala Leu Thr Gln Pro 
                165                 170                 175     
Ala Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
            180                 185                 190         
Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
    210                 215                 220                 
Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
225                 230                 235                 240 
Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
                245                 250                 255     
Gln Val Trp Asp Ser Ser Ser Asp Leu Val Val Phe Gly Gly Gly Thr 
            260                 265                 270         
Lys Leu Thr Val Leu Gly Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys 
    290                 295                 300                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Ala Pro 
305                 310                 315                 320 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            340                 345                 350         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile Glu Lys 
                405                 410                 415     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                485                 490                 495     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        515                 520                 525             
Lys Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Ser Gly Gly 
    530                 535                 540                 
Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Thr Pro 
545                 550                 555                 560 
Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
                565                 570                 575     
Asp Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Gln Gly Leu Glu 
            580                 585                 590         
Trp Leu Gly Val Ile Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser Ala 
        595                 600                 605             
Leu Met Ser Arg Lys Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val 
    610                 615                 620                 
Phe Leu Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr 
625                 630                 635                 640 
Cys Ala Arg Asp Lys Gly Tyr Ser Tyr Tyr Tyr Ser Met Asp Tyr Trp 
                645                 650                 655     
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Arg Gly Gly Gly Ser Gly 
            660                 665                 670         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
        675                 680                 685             
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
    690                 695                 700                 
Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 
705                 710                 715                 720 
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala 
                725                 730                 735     
Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            740                 745                 750         
Gly Thr Asn Phe Ser Leu Asn Ile His Pro Val Asp Glu Asp Asp Val 
        755                 760                 765             
Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Tyr Thr Phe Gly 
    770                 775                 780                 
Gly Gly Thr Lys Leu Glu Ile Lys Arg 
785                 790             

<210> 45
<211> 792
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-HBsAg scFv [C8]^Glycin-Serin-Linker^hIgG1-Fc[C245S,L259F,L26
      0E,G262A,A355T]^StrepTag^Glycin-Linker^ StrepTag^anti-CD16 scFv
      [A9]

<400> 45
Met Asp Phe Glu Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Met Ser Arg Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          
Gly Leu Leu Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              
Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  
Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser 
65                  70                  75                  80  
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         
Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Pro Pro Gly Arg Gln Glu Tyr 
        115                 120                 125             
Tyr Gly Ser Ser Ile Tyr Tyr Phe Pro Leu Gly Asn Trp Gly Gln Gly 
    130                 135                 140                 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys Leu Glu 
145                 150                 155                 160 
Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Ala Leu Thr Gln Pro 
                165                 170                 175     
Ala Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
            180                 185                 190         
Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
    210                 215                 220                 
Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
225                 230                 235                 240 
Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
                245                 250                 255     
Gln Val Trp Asp Ser Ser Ser Asp Leu Val Val Phe Gly Gly Gly Thr 
            260                 265                 270         
Lys Leu Thr Val Leu Gly Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys 
    290                 295                 300                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Ala Pro 
305                 310                 315                 320 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            340                 345                 350         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile Glu Lys 
                405                 410                 415     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                485                 490                 495     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        515                 520                 525             
Lys Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Arg Gly Gly 
    530                 535                 540                 
Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
545                 550                 555                 560 
Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                565                 570                 575     
Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu 
            580                 585                 590         
Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu 
        595                 600                 605             
Lys Phe Lys Gly Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Arg Thr 
    610                 615                 620                 
Ala Tyr Val Gln Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
625                 630                 635                 640 
Phe Cys Ala Arg Ser Ala Ser Trp Tyr Phe Asp Val Trp Gly Ala Gly 
                645                 650                 655     
Thr Thr Val Thr Val Ser Ser Gly Asn Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Gln Ala Val Val Thr 
        675                 680                 685             
Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr 
    690                 695                 700                 
Cys Arg Ser Asn Thr Gly Thr Val Thr Thr Ser Asn Tyr Ala Asn Trp 
705                 710                 715                 720 
Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly His Thr 
                725                 730                 735     
Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile 
            740                 745                 750         
Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu 
        755                 760                 765             
Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Asn Asn His Trp Val Phe Gly 
    770                 775                 780                 
Gly Gly Thr Lys Leu Thr Val Leu 
785                 790         

<210> 46
<211> 799
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-HBsAg scFv [C8]^Glycin-Serin-Linker^hIgG1-Fc[C245S,L259F,L26
      0E,G262A,A355T]^StrepTag^Glycin-Linker^ StrepTag^anti-CD56 scFv
      [NCAM29.2]

<400> 46
Met Asp Phe Glu Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Met Ser Arg Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          
Gly Leu Leu Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              
Gly Phe Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  
Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Gly Ser 
65                  70                  75                  80  
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         
Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Pro Pro Gly Arg Gln Glu Tyr 
        115                 120                 125             
Tyr Gly Ser Ser Ile Tyr Tyr Phe Pro Leu Gly Asn Trp Gly Gln Gly 
    130                 135                 140                 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys Leu Glu 
145                 150                 155                 160 
Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Ala Leu Thr Gln Pro 
                165                 170                 175     
Ala Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
            180                 185                 190         
Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
    210                 215                 220                 
Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
225                 230                 235                 240 
Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
                245                 250                 255     
Gln Val Trp Asp Ser Ser Ser Asp Leu Val Val Phe Gly Gly Gly Thr 
            260                 265                 270         
Lys Leu Thr Val Leu Gly Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys 
    290                 295                 300                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Ala Pro 
305                 310                 315                 320 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            340                 345                 350         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile Glu Lys 
                405                 410                 415     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                485                 490                 495     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        515                 520                 525             
Lys Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Ser Gly Gly 
    530                 535                 540                 
Gly Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
545                 550                 555                 560 
Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                565                 570                 575     
Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu 
            580                 585                 590         
Trp Val Ala Tyr Ile Ser Ser Gly Ser Tyr Ala Ile Tyr Tyr Ala Asp 
        595                 600                 605             
Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Glu Asn Thr 
    610                 615                 620                 
Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Ser Ala Met Tyr 
625                 630                 635                 640 
Tyr Cys Val Arg Gly Arg Arg Leu Gly Glu Gly Tyr Ala Met Asp Tyr 
                645                 650                 655     
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Asn Ser Gly Gly 
            660                 665                 670         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
        675                 680                 685             
Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu 
    690                 695                 700                 
Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser 
705                 710                 715                 720 
Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                725                 730                 735     
Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro 
            740                 745                 750         
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        755                 760                 765             
Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
    770                 775                 780                 
Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
785                 790                 795                 

<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 47
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 48
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      
Val 
    

<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 49
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

