                         SEQUENCE LISTING

<110>  Amgen Research (Munich) GmbH
       Amgen Inc.
 
<120>  Combination of epigenetic factors and bispecific compounds 
       targeting CD33 and CD3 in the treatment of myeloid leukemia

<130>  AMG14853PCT

<150>  US 61/877,714
<151>  2013-09-13

<160>  227   

<170>  PatentIn version 3.3

<210>  1
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of AH3

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Ser Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of AH3

<400>  2

Asn Tyr Gly Met Asn 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of AH3

<400>  3

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of AH3

<400>  4

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  5
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of AH3

<400>  5
caggtgcagc tggtgcagtc tggagctgag gtgaaaaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaggcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg tcttcggata cctctaccag cactgcctat    240

ttggaaatca acagcctcag aagtgatgac acggctatat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  6
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of AH3

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Lys Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of AH3

<400>  7

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of AH3

<400>  8

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of AH3

<400>  9

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  10
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of AH3

<400>  10
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca agaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  11
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 CD33 HL of AH3

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Ser Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  12
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of AH3

<400>  12
caggtgcagc tggtgcagtc tggagctgag gtgaaaaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaggcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg tcttcggata cctctaccag cactgcctat    240

ttggaaatca acagcctcag aagtgatgac acggctatat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  13
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH3 HL x H2C HL

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Ser Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  14
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH3 HL x H2C HL

<400>  14
caggtgcagc tggtgcagtc tggagctgag gtgaaaaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaggcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg tcttcggata cctctaccag cactgcctat    240

ttggaaatca acagcctcag aagtgatgac acggctatat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  15
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH3 HL x F12Q HL

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Ser Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  16
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH3 HL x F12Q HL

<400>  16
caggtgcagc tggtgcagtc tggagctgag gtgaaaaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaggcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg tcttcggata cctctaccag cactgcctat    240

ttggaaatca acagcctcag aagtgatgac acggctatat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  17
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH3 HL x I2C HL

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Ser Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  18
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH3 HL x I2C HL

<400>  18
caggtgcagc tggtgcagtc tggagctgag gtgaaaaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaggcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg tcttcggata cctctaccag cactgcctat    240

ttggaaatca acagcctcag aagtgatgac acggctatat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  19
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of AF5

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of AF5

<400>  20

Asn Tyr Gly Met Asn 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of AF5

<400>  21

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of AF5

<400>  22

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  23
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of AF5

<400>  23
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcgtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

ttggaactcc acaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  24
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of AF5

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Lys Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  25
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of AF5

<400>  25

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of AF5

<400>  26

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of AF5

<400>  27

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  28
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33VL of AF5

<400>  28
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca agaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  29
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33HL of AF5

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  30
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33HL of AF5

<400>  30
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcgtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

ttggaactcc acaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  31
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AF5 HL x H2C HL

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  32
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AF5 HL x H2C HL

<400>  32
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcgtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

ttggaactcc acaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  33
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AF5 HL x F12Q HL

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  34
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AF5 HL x F12Q HL

<400>  34
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcgtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

ttggaactcc acaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  35
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AF5 HL x I2C HL

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  36
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AF5 HL x I2C HL

<400>  36
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcgtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

ttggaactcc acaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  37
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of AC8

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Asn Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of AC8

<400>  38

Asn Tyr Gly Met Asn 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of AC8

<400>  39

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of AC8

<400>  40

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  41
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of AC8

<400>  41
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aaatgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  42
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of AC8

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Lys Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  43
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of AC8

<400>  43

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  44
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of AC8

<400>  44

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of AC8

<400>  45

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  46
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of AC8

<400>  46
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca agaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  47
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of AC8

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Asn Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  48
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of AC8

<400>  48
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aaatgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  49
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AC8 HL x H2C HL

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Asn Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  50
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AC8 HL x H2C HL

<400>  50
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aaatgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  51
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AC8 HL x F12Q HL

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Asn Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  52
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AC8 HL x F12Q HL

<400>  52
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aaatgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  53
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AC8 HL x I2C HL

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Asn Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  54
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AC8 HL x I2C HL

<400>  54
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aaatgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  55
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of AH11

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of AH11

<400>  56

Asn Tyr Gly Met Asn 
1               5   


<210>  57
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of AH11

<400>  57

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  58

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  59
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of AH11

<400>  59
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

atggaaatca gcagcctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  60
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of AH11

<400>  60

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Lys Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  61
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of AH11

<400>  61

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  62
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of AH11

<400>  62

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33LCDR3 of AH11

<400>  63

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  64
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of AH11

<400>  64
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca agaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  65
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of AH11

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  66
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of AH11

<400>  66
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

atggaaatca gcagcctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  67
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH11 HL x H2C HL

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  68
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH11 HL x H2C HL

<400>  68
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

atggaaatca gcagcctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  69
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH11 HL x F12Q HL

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  70
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH11 HL x F12Q HL

<400>  70
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

atggaaatca gcagcctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  71
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 AH11 HL x I2C HL

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  72
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 AH11 HL x I2C HL

<400>  72
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat    180

gctgatgact tcaagggacg ggttaccatg acttcggata cctctaccag cactgcctat    240

atggaaatca gcagcctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aagaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  73
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of B3

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  74
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of B3

<400>  74

Asn Tyr Gly Met Asn 
1               5   


<210>  75
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of B3

<400>  75

Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of B3

<400>  76

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  77
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of B3

<400>  77
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  78
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of B3

<400>  78

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Met Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Thr Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile 
            100                 105                 110         


Lys 
    


<210>  79
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of B3

<400>  79

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  80
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of B3

<400>  80

Trp Ala Ser Thr Arg Glu 
1               5       


<210>  81
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33LCDR3 of B3

<400>  81

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  82
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of B3

<400>  82
gacatcgtga tgacacagtc tccagactcc atgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca cgaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gacattaaa                           339


<210>  83
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of B3

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Met Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys 
                245                 250 


<210>  84
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of B3

<400>  84
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc catgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggacattaaa                                     750


<210>  85
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B3 HL x H2C HL

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Met Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  86
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B3 HL x H2C HL

<400>  86
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc catgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggacattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  87
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B3 HL x F12Q HL

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Met Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  88
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B3 HL x F12Q HL

<400>  88
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc catgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggacattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  89
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B3 HL x I2C HL

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Met Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  90
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B3 HL x I2C HL

<400>  90
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc catgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggacattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  91
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of F2

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  92
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of F2

<400>  92

Asn Tyr Gly Met Asn 
1               5   


<210>  93
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of F2

<400>  93

Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of F2

<400>  94

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  95
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of F2

<400>  95
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  96
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of F2

<400>  96

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Thr Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  97
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of F2

<400>  97

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  98
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of F2

<400>  98

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  99
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of F2

<400>  99

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  100
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of F2

<400>  100
gacatcgtga tgacacagtc tccagactcc ctgtctgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca cgaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  101
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of F2

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  102
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of F2

<400>  102
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgtctgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  103
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 F2 HL x H2C HL

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  104
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 F2 HL x H2C HL

<400>  104
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgtctgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  105
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 F2 HL x F12Q HL

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  106
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 F2 HL x F12Q HL

<400>  106
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgtctgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  107
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 F2 HL x I2C HL

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Asn Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  108
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 F2 HL x I2C HL

<400>  108
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gacaaactat    180

gctgataagt tccagggacg cgttaccttc acttcggata cctctaccag cactgcctat    240

atggaactcc gcaacctcaa aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgtctgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  109
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of B10

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  110
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of B10

<400>  110

Asn Tyr Gly Met Asn 
1               5   


<210>  111
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33HCDR2 of B10

<400>  111

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of B10

<400>  112

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  113
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of B10

<400>  113
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggtgagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctca                                                               366


<210>  114
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of B10

<400>  114

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Gly Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  115
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of B10

<400>  115

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  116
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of B10

<400>  116

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of B10

<400>  117

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  118
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of B10

<400>  118
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca acaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcggttctg ggacagattt cactctcact    240

attgacggcc tgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  119
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of B10

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Gly Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  120
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of B10

<400>  120
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggtgagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aacaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcggttct gggacagatt tcactctcac tattgacggc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  121
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B10 HL x H2C HL

<400>  121

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Gly Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  122
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B10 HL x H2C HL

<400>  122
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggtgagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aacaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcggttct gggacagatt tcactctcac tattgacggc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  123
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B10 HL x F12Q HL

<400>  123

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Gly Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  124
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B10 HL x F12Q HL

<400>  124
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggtgagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aacaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcggttct gggacagatt tcactctcac tattgacggc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  125
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 B10 HL x I2C HL

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Gly Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  126
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 B10 HL x I2C HL

<400>  126
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggtgagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcag aagtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcactac ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc aacaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcggttct gggacagatt tcactctcac tattgacggc    660

ctgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  127
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VH of E11

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  128
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR1 of E11

<400>  128

Asn Tyr Gly Met Asn 
1               5   


<210>  129
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR2 of E11

<400>  129

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HCDR3 of E11

<400>  130

Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210>  131
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VH of E11

<400>  131
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctca                                                               366


<210>  132
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD33 VL of E11

<400>  132

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Thr Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Ser Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Ala His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  133
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR1 of E11

<400>  133

Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  134
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR2 of E11

<400>  134

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CD33 LCDR3 of E11

<400>  135

Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210>  136
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  CD33 VL of E11

<400>  136
gacatcgtga tgacacagtc tccagactcc ctgactgtgt ctctgggcga gaggaccacc     60

atcaactgca agtccagcca gagtgtttta gacagctcca cgaataagaa ctccttagct    120

tggtaccagc agaaaccagg acagcctcct aaattactcc tttcctgggc atctacgcgg    180

gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcact    240

attgacagcc cgcagcctga agattctgca acttactatt gtcaacagtc tgcccacttc    300

ccgatcacct ttggccaagg gacacgactg gagattaaa                           339


<210>  137
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  CD33 HL of E11

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250 


<210>  138
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  CD33 HL of E11

<400>  138
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ccgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa                                     750


<210>  139
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 E11 HL x H2C HL

<400>  139

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  140
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 E11 HL x H2C HL

<400>  140
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ccgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggctactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgc tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  141
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 E11 HL x F12Q HL

<400>  141

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  142
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 E11 HL x F12Q HL

<400>  142
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ccgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaatag ctacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag gcaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acgtttcctg gtgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  143
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 E11 HL x I2C HL

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


<210>  144
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 E11 HL x I2C HL

<400>  144
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ccgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tccta                                                    1515


<210>  145
<211>  1125
<212>  DNA
<213>  human

<400>  145
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactccgat     60

ccaaatttct ggctgcaagt gcaggagtca gtgacggtac aggagggttt gtgcgtcctc    120

gtgccctgca ctttcttcca tcccataccc tactacgaca agaactcccc agttcatggt    180

tactggttcc gggaaggagc cattatatcc ggggactctc cagtggccac aaacaagcta    240

gatcaagaag tacaggagga gactcagggc agattccgcc tccttgggga tcccagtagg    300

aacaactgct ccctgagcat cgtagacgcc aggaggaggg ataatggttc atacttcttt    360

cggatggaga gaggaagtac caaatacagt tacaaatctc cccagctctc tgtgcatgtg    420

acagacttga cccacaggcc caaaatcctc atccctggca ctctagaacc cggccactcc    480

aaaaacctga cctgctctgt gtcctgggcc tgtgagcagg gaacaccccc gatcttctcc    540

tggttgtcag ctgcccccac ctccctgggc cccaggacta ctcactcctc ggtgctcata    600

atcaccccac ggccccagga ccacggcacc aacctgacct gtcaggtgaa gttcgctgga    660

gctggtgtga ctacggagag aaccatccag ctcaacgtca cctatgttcc acagaaccca    720

acaactggta tctttccagg agatggctca gggaaacaag agaccagagc aggagtggtt    780

catggggcca ttggaggagc tggtgttaca gccctgctcg ctctttgtct ctgcctcatc    840

ttcttcatag tgaagaccca caggaggaaa gcagccagga cagcagtggg caggaatgac    900

acccacccta ccacagggtc agcctccccg aaacaccaga agaagtccaa gttacatggc    960

cccactgaaa cctcaagctg ttcaggtgcc gcccctactg tggagatgga tgaggagctg   1020

cattatgctt ccctcaactt tcatgggatg aatccttcca aggacacctc caccgaatac   1080

tcagaggtca ggacccagtc cgggcatcat caccatcatc attga                   1125


<210>  146
<211>  374
<212>  PRT
<213>  human

<400>  146

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr 
            20                  25                  30          


Val Gln Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro 
        35                  40                  45              


Ile Pro Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Glu Gly Ala Ile Ile Ser Gly Asp Ser Pro Val Ala Thr Asn Lys Leu 
65                  70                  75                  80  


Asp Gln Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly 
                85                  90                  95      


Asp Pro Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg 
            100                 105                 110         


Arg Asp Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys 
        115                 120                 125             


Tyr Ser Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr 
    130                 135                 140                 


His Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser 
145                 150                 155                 160 


Lys Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro 
                165                 170                 175     


Pro Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg 
            180                 185                 190         


Thr Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His 
        195                 200                 205             


Gly Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr 
    210                 215                 220                 


Thr Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro 
225                 230                 235                 240 


Thr Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg 
                245                 250                 255     


Ala Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu 
            260                 265                 270         


Leu Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg 
        275                 280                 285             


Arg Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr 
    290                 295                 300                 


Thr Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly 
305                 310                 315                 320 


Pro Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met 
                325                 330                 335     


Asp Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro 
            340                 345                 350         


Ser Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln Ser Gly 
        355                 360                 365             


His His His His His His 
    370                 


<210>  147
<211>  1083
<212>  DNA
<213>  macaque

<400>  147
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaga     60

gtcaggctgg aagtgcagga gtcagtgaca gtacaggagg gtttgtgcgt ccttgtgccc    120

tgcactttct tccatcccgt accctaccac accaggaatt ccccagttca tggttactgg    180

ttccgggaag gagccattgt atccttggac tctccagtgg ccacaaacaa gctagatcaa    240

gaagtacagg aggagaccca gggccgattc cgcctccttg gggatcccag taggaacaac    300

tgctccctga gcatcgtaga tgccaggagg agggataacg gttcatactt ctttcggatg    360

gagaaaggaa gtaccaaata cagttacaaa tctacccagc tctctgtgca tgtgacagac    420

ttgacccaca ggccccaaat cctcatccct ggagccctag accctgacca ctccaaaaac    480

ctgacctgct ctgtgccctg ggcctgtgag cagggaacac ctccaatctt ctcctggatg    540

tcagctgccc ccacctccct gggcctcagg accactcact cctcggtgct cataatcacc    600

ccacggcccc aggaccacgg caccaacctc acctgtcagg tgaagttccc tggagctggc    660

gtgaccacgg agagaaccat ccagctcaat gtctcctatg cttcacagaa cccaagaact    720

gatatctttc taggagacgg ctcagggaaa caaggagtgg ttcagggagc catcggggga    780

gctggtgtca cagtcctgct cgctctttgt ctctgcctca tcttcttcac agtgaagact    840

cacaggagga aagcagccag gacagcagtg ggcaggatcg acacccaccc cgccacaggg    900

ccaacatcct cgaaacacca gaagaagtcc aagttacatg gcgccactga aacctcaggc    960

tgttcaggta ccacccttac tgtggagatg gatgaggagc tgcactacgc ttccctcaac   1020

tttcatggga tgaatccttc tgaggacacc tccaccgaat actcagaggt caggacccag   1080

tga                                                                 1083


<210>  148
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 UD H2C HL x AF5 HL

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
        275                 280                 285             


Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
    290                 295                 300                 


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
305                 310                 315                 320 


Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Leu 
                325                 330                 335     


Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
385                 390                 395                 400 


Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys Lys 
                405                 410                 415     


Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser Trp 
        435                 440                 445             


Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu Asp 
465                 470                 475                 480 


Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            500                 505 


<210>  149
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 UD H2C HL x AF5 HL

<400>  149
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc     60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct    120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca    180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact    240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga    300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg    360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct    420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc    480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa    540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact    600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta    660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc    720

ggtggaggaa ccaaactgac tgtcctatcc ggaggtggtg gctcccaggt gcagctggtc    780

cagtctggag ctgaggtgaa gaagcctgga gcgtcagtca aggtctcctg caaggctagc    840

gggtatacct tcacaaacta tggaatgaac tgggtgaagc aggctccagg acagggttta    900

aagtggatgg gctggataaa cacctacact ggagagccaa catatgctga tgacttcaag    960

ggacgggtta ccatgacttc ggatacctct accagcactg cctatttgga actccacaac   1020

ctcagaagtg atgacacggc tgtatattac tgtgcgcgct ggagttggag tgatggttac   1080

tacgtttact ttgactactg gggccaaggc actacggtca ccgtctcctc aggtggtggt   1140

ggttctggcg gcggcggctc cggtggtggt ggttctgaca tcgtgatgac acagtctcca   1200

gactccctga ctgtgtctct gggcgagagg accaccatca actgcaagtc cagccagagt   1260

gttttagaca gctccaagaa taagaactcc ttagcttggt accagcagaa accaggacag   1320

cctcctaaat tactcctttc ctgggcatct acgcgggaat ccgggatccc tgaccgattc   1380

agtggcagcg ggtctgggac agatttcact ctcactattg acagcctgca gcctgaagat   1440

tctgcaactt actattgtca acagtctgcc cacttcccga tcacctttgg ccaagggaca   1500

cgactggaga ttaaa                                                    1515


<210>  150
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 UD F12Q HL x AF5 HL

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
        275                 280                 285             


Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
    290                 295                 300                 


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
305                 310                 315                 320 


Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Leu 
                325                 330                 335     


Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
385                 390                 395                 400 


Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys Lys 
                405                 410                 415     


Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser Trp 
        435                 440                 445             


Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu Asp 
465                 470                 475                 480 


Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            500                 505 


<210>  151
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 UD F12Q HL x AF5 HL

<400>  151
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc     60

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct    120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca    180

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact    240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga    300

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg    360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct    420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc    480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa    540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact    600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta    660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc    720

ggtggaggaa ccaaactgac tgtcctatcc ggaggtggtg gctcccaggt gcagctggtc    780

cagtctggag ctgaggtgaa gaagcctgga gcgtcagtca aggtctcctg caaggctagc    840

gggtatacct tcacaaacta tggaatgaac tgggtgaagc aggctccagg acagggttta    900

aagtggatgg gctggataaa cacctacact ggagagccaa catatgctga tgacttcaag    960

ggacgggtta ccatgacttc ggatacctct accagcactg cctatttgga actccacaac   1020

ctcagaagtg atgacacggc tgtatattac tgtgcgcgct ggagttggag tgatggttac   1080

tacgtttact ttgactactg gggccaaggc actacggtca ccgtctcctc aggtggtggt   1140

ggttctggcg gcggcggctc cggtggtggt ggttctgaca tcgtgatgac acagtctcca   1200

gactccctga ctgtgtctct gggcgagagg accaccatca actgcaagtc cagccagagt   1260

gttttagaca gctccaagaa taagaactcc ttagcttggt accagcagaa accaggacag   1320

cctcctaaat tactcctttc ctgggcatct acgcgggaat ccgggatccc tgaccgattc   1380

agtggcagcg ggtctgggac agatttcact ctcactattg acagcctgca gcctgaagat   1440

tctgcaactt actattgtca acagtctgcc cacttcccga tcacctttgg ccaagggaca   1500

cgactggaga ttaaa                                                    1515


<210>  152
<211>  505
<212>  PRT
<213>  artificial

<220>
<223>  CD33 UD I2C HL x AF5 HL

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
        275                 280                 285             


Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
    290                 295                 300                 


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
305                 310                 315                 320 


Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Leu 
                325                 330                 335     


Glu Leu His Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
385                 390                 395                 400 


Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys Lys 
                405                 410                 415     


Ser Ser Gln Ser Val Leu Asp Ser Ser Lys Asn Lys Asn Ser Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser Trp 
        435                 440                 445             


Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro Glu Asp 
465                 470                 475                 480 


Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            500                 505 


<210>  153
<211>  1515
<212>  DNA
<213>  artificial

<220>
<223>  CD33 UD I2C HL x AF5 HL

<400>  153
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc     60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct    120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca    180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact    240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga    300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg    360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct    420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc    480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa    540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact    600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta    660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc    720

ggtggaggaa ccaaactgac tgtcctatcc ggaggtggtg gctcccaggt gcagctggtc    780

cagtctggag ctgaggtgaa gaagcctgga gcgtcagtca aggtctcctg caaggctagc    840

gggtatacct tcacaaacta tggaatgaac tgggtgaagc aggctccagg acagggttta    900

aagtggatgg gctggataaa cacctacact ggagagccaa catatgctga tgacttcaag    960

ggacgggtta ccatgacttc ggatacctct accagcactg cctatttgga actccacaac   1020

ctcagaagtg atgacacggc tgtatattac tgtgcgcgct ggagttggag tgatggttac   1080

tacgtttact ttgactactg gggccaaggc actacggtca ccgtctcctc aggtggtggt   1140

ggttctggcg gcggcggctc cggtggtggt ggttctgaca tcgtgatgac acagtctcca   1200

gactccctga ctgtgtctct gggcgagagg accaccatca actgcaagtc cagccagagt   1260

gttttagaca gctccaagaa taagaactcc ttagcttggt accagcagaa accaggacag   1320

cctcctaaat tactcctttc ctgggcatct acgcgggaat ccgggatccc tgaccgattc   1380

agtggcagcg ggtctgggac agatttcact ctcactattg acagcctgca gcctgaagat   1440

tctgcaactt actattgtca acagtctgcc cacttcccga tcacctttgg ccaagggaca   1500

cgactggaga ttaaa                                                    1515


<210>  154
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of F6A

<400>  154

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  155
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of F6A

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  156
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of F6A

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  157
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of F6A

<400>  157

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  158
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of F6A

<400>  158

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  159
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of F6A

<400>  159

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  160
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of H2C

<400>  160

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  161
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of H2C

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  162
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of H2C

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  163
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of H2C

<400>  163

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  164
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of H2C

<400>  164

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  165
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of H2C

<400>  165

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  166
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of H1E

<400>  166

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  167
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of H1E

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  168
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of H1E

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  169
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of H1E

<400>  169

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  170
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of H1E

<400>  170

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  171
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of H1E

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  172
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VL of G4H

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  173
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of G4H

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  174
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of G4H

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  175
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of G4H

<400>  175

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  176
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of G4H

<400>  176

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  177
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of G4H

<400>  177

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  178
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of A2J

<400>  178

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  179
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of A2J

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  180
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of A2J

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  181
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of A2J

<400>  181

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  182
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of A2J

<400>  182

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  183
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of A2J

<400>  183

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  184
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of E1L

<400>  184

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  185
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of E1L

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  186
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of E1L

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  187
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of E1L

<400>  187

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  188
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of E1L

<400>  188

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  189
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of E1L

<400>  189

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  190
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of E2M

<400>  190

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  191
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of E2M

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  192
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of E2M

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  193
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of E2M

<400>  193

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  194
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of E2M

<400>  194

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  195
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of E2M

<400>  195

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  196
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of F7O

<400>  196

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  197
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of F7O

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  198
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of F7O

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  199
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of F7O

<400>  199

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  200
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of F7O

<400>  200

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  201
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of F7O

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  202
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of F12Q

<400>  202

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  203
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of F12Q

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  204
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of F12Q

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  205
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of F12Q

<400>  205

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  206
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of F12Q

<400>  206

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  207
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of F12Q

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  208
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of I2C

<400>  208

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  209
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of I2C

<400>  209

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  210
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of I2C

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  211
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of I2C

<400>  211

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  212
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of I2C

<400>  212

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  213
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of I2C

<400>  213

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  214
<211>  1587
<212>  DNA
<213>  artificial

<220>
<223>  SA21-CD33 E11 HL x I2C HL (His Tag)

<400>  214
cgcctgattg aagatatttg cctgccgcgc tggggctgcc tgtgggaaga tgatcaggtg     60

cagctggtgc agtctggagc tgaggtgaag aagcctggag agtcagtcaa ggtctcctgc    120

aaggctagcg ggtatacctt cacaaactat ggaatgaact gggtgaagca ggctccagga    180

cagggtttag agtggatggg ctggataaac acctacactg gagagccaac ctatgctgat    240

aagttccagg gacgcgttac catgactacg gatacctcta ccagcactgc ctatatggaa    300

atccgcaacc tcggaggtga tgacacggct gtatattact gtgcgcgctg gagttggagt    360

gatggttact acgtttactt tgactactgg ggccaaggca cttcggtcac cgtctcctca    420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacat cgtgatgaca    480

cagtctccag actccctgac tgtgtctctg ggcgagagga ccaccatcaa ctgcaagtcc    540

agccagagtg ttttagacag ctccacgaat aagaactcct tagcttggta ccagcagaaa    600

ccaggacagc ctcctaaatt actcctttcc tgggcatcta cgcgggaatc cgggatccct    660

gaccgattca gtggcagcgg gtctgggaca gatttcactc tcactattga cagcccgcag    720

cctgaagatt ctgcaactta ctattgtcaa cagtctgccc acttcccgat cacctttggc    780

caagggacac gactggagat taaatccgga ggtggtggct ccgaggtgca gctggtcgag    840

tctggaggag gattggtgca gcctggaggg tcattgaaac tctcatgtgc agcctctgga    900

ttcaccttca ataagtacgc catgaactgg gtccgccagg ctccaggaaa gggtttggaa    960

tgggttgctc gcataagaag taaatataat aattatgcaa catattatgc cgattcagtg   1020

aaagacaggt tcaccatctc cagagatgat tcaaaaaaca ctgcctatct acaaatgaac   1080

aacttgaaaa ctgaggacac tgccgtgtac tactgtgtga gacatgggaa cttcggtaat   1140

agctacatat cctactgggc ttactggggc caagggactc tggtcaccgt ctcctcaggt   1200

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctcagactgt tgtgactcag   1260

gaaccttcac tcaccgtatc acctggtgga acagtcacac tcacttgtgg ctcctcgact   1320

ggggctgtta catctggcaa ctacccaaac tgggtccaac aaaaaccagg tcaggcaccc   1380

cgtggtctaa taggtgggac taagttcctc gcccccggta ctcctgccag attctcaggc   1440

tccctgcttg gaggcaaggc tgccctcacc ctctcagggg tacagccaga ggatgaggca   1500

gaatattact gtgttctatg gtacagcaac cgctgggtgt tcggtggagg aaccaaactg   1560

actgtcctac atcaccatca ccatcac                                       1587


<210>  215
<211>  529
<212>  PRT
<213>  artificial

<220>
<223>  SA21-CD33 E11 HL x I2C HL H6

<400>  215

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            20                  25                  30          


Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              


Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp 
65                  70                  75                  80  


Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr 
                85                  90                  95      


Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile 
                165                 170                 175     


Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn 
            180                 185                 190         


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln 
225                 230                 235                 240 


Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro 
                245                 250                 255     


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        275                 280                 285             


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
    290                 295                 300                 


Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
            340                 345                 350         


Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
    370                 375                 380                 


Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr 
                405                 410                 415     


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
            420                 425                 430         


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
        435                 440                 445             


Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
    450                 455                 460                 


Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                485                 490                 495     


Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp 
            500                 505                 510         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu His His His His His 
        515                 520                 525             


His 
    


<210>  216
<211>  1575
<212>  DNA
<213>  artificial

<220>
<223>  SA25-CD33 E11 HL x I2C HL with His tag

<400>  216
gaggacatct gcctgcccag atggggctgc ctgtgggagg accaggtgca gctggtgcag     60

tctggagctg aggtgaagaa gcctggagag tcagtcaagg tctcctgcaa ggctagcggg    120

tataccttca caaactatgg aatgaactgg gtgaagcagg ctccaggaca gggtttagag    180

tggatgggct ggataaacac ctacactgga gagccaacct atgctgataa gttccaggga    240

cgcgttacca tgactacgga tacctctacc agcactgcct atatggaaat ccgcaacctc    300

ggaggtgatg acacggctgt atattactgt gcgcgctgga gttggagtga tggttactac    360

gtttactttg actactgggg ccaaggcact tcggtcaccg tctcctcagg tggtggtggt    420

tctggcggcg gcggctccgg tggtggtggt tctgacatcg tgatgacaca gtctccagac    480

tccctgactg tgtctctggg cgagaggacc accatcaact gcaagtccag ccagagtgtt    540

ttagacagct ccacgaataa gaactcctta gcttggtacc agcagaaacc aggacagcct    600

cctaaattac tcctttcctg ggcatctacg cgggaatccg ggatccctga ccgattcagt    660

ggcagcgggt ctgggacaga tttcactctc actattgaca gcccgcagcc tgaagattct    720

gcaacttact attgtcaaca gtctgcccac ttcccgatca cctttggcca agggacacga    780

ctggagatta aatccggagg tggtggctcc gaggtgcagc tggtcgagtc tggaggagga    840

ttggtgcagc ctggagggtc attgaaactc tcatgtgcag cctctggatt caccttcaat    900

aagtacgcca tgaactgggt ccgccaggct ccaggaaagg gtttggaatg ggttgctcgc    960

ataagaagta aatataataa ttatgcaaca tattatgccg attcagtgaa agacaggttc   1020

accatctcca gagatgattc aaaaaacact gcctatctac aaatgaacaa cttgaaaact   1080

gaggacactg ccgtgtacta ctgtgtgaga catgggaact tcggtaatag ctacatatcc   1140

tactgggctt actggggcca agggactctg gtcaccgtct cctcaggtgg tggtggttct   1200

ggcggcggcg gctccggtgg tggtggttct cagactgttg tgactcagga accttcactc   1260

accgtatcac ctggtggaac agtcacactc acttgtggct cctcgactgg ggctgttaca   1320

tctggcaact acccaaactg ggtccaacaa aaaccaggtc aggcaccccg tggtctaata   1380

ggtgggacta agttcctcgc ccccggtact cctgccagat tctcaggctc cctgcttgga   1440

ggcaaggctg ccctcaccct ctcaggggta cagccagagg atgaggcaga atattactgt   1500

gttctatggt acagcaaccg ctgggtgttc ggtggaggaa ccaaactgac tgtcctacat   1560

caccatcacc atcac                                                    1575


<210>  217
<211>  525
<212>  PRT
<213>  artificial

<220>
<223>  SA25-CD33 E11 HL x I2C HL H6

<400>  217

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Gln Val 
1               5                   10                  15      


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Val 
            20                  25                  30          


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met 
        35                  40                  45              


Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
    50                  55                  60                  


Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe Gln Gly 
65                  70                  75                  80  


Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
                85                  90                  95      


Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
145                 150                 155                 160 


Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys Lys Ser 
                165                 170                 175     


Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser Trp Ala 
        195                 200                 205             


Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu Asp Ser 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 
    290                 295                 300                 


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
305                 310                 315                 320 


Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
            340                 345                 350         


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                405                 410                 415     


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
            420                 425                 430         


Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 
    450                 455                 460                 


Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
465                 470                 475                 480 


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                485                 490                 495     


Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Leu Thr Val Leu His His His His His His 
        515                 520                 525 


<210>  218
<211>  1596
<212>  DNA
<213>  artificial

<220>
<223>  SA08-CD33 E11 HL x I2C HL with His tag

<400>  218
cagggcctga tcggcgacat ctgcctgccc agatggggct gcctgtgggg cgactccgtg     60

aaacaggtgc agctggtgca gtctggagct gaggtgaaga agcctggaga gtcagtcaag    120

gtctcctgca aggctagcgg gtataccttc acaaactatg gaatgaactg ggtgaagcag    180

gctccaggac agggtttaga gtggatgggc tggataaaca cctacactgg agagccaacc    240

tatgctgata agttccaggg acgcgttacc atgactacgg atacctctac cagcactgcc    300

tatatggaaa tccgcaacct cggaggtgat gacacggctg tatattactg tgcgcgctgg    360

agttggagtg atggttacta cgtttacttt gactactggg gccaaggcac ttcggtcacc    420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttctgacatc    480

gtgatgacac agtctccaga ctccctgact gtgtctctgg gcgagaggac caccatcaac    540

tgcaagtcca gccagagtgt tttagacagc tccacgaata agaactcctt agcttggtac    600

cagcagaaac caggacagcc tcctaaatta ctcctttcct gggcatctac gcgggaatcc    660

gggatccctg accgattcag tggcagcggg tctgggacag atttcactct cactattgac    720

agcccgcagc ctgaagattc tgcaacttac tattgtcaac agtctgccca cttcccgatc    780

acctttggcc aagggacacg actggagatt aaatccggag gtggtggctc cgaggtgcag    840

ctggtcgagt ctggaggagg attggtgcag cctggagggt cattgaaact ctcatgtgca    900

gcctctggat tcaccttcaa taagtacgcc atgaactggg tccgccaggc tccaggaaag    960

ggtttggaat gggttgctcg cataagaagt aaatataata attatgcaac atattatgcc   1020

gattcagtga aagacaggtt caccatctcc agagatgatt caaaaaacac tgcctatcta   1080

caaatgaaca acttgaaaac tgaggacact gccgtgtact actgtgtgag acatgggaac   1140

ttcggtaata gctacatatc ctactgggct tactggggcc aagggactct ggtcaccgtc   1200

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tcagactgtt   1260

gtgactcagg aaccttcact caccgtatca cctggtggaa cagtcacact cacttgtggc   1320

tcctcgactg gggctgttac atctggcaac tacccaaact gggtccaaca aaaaccaggt   1380

caggcacccc gtggtctaat aggtgggact aagttcctcg cccccggtac tcctgccaga   1440

ttctcaggct ccctgcttgg aggcaaggct gccctcaccc tctcaggggt acagccagag   1500

gatgaggcag aatattactg tgttctatgg tacagcaacc gctgggtgtt cggtggagga   1560

accaaactga ctgtcctaca tcaccatcac catcac                             1596


<210>  219
<211>  532
<212>  PRT
<213>  artificial

<220>
<223>  SA08-CD33 E11 HL x I2C HL H6

<400>  219

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val Lys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg 
                165                 170                 175     


Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr 
            180                 185                 190         


Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        195                 200                 205             


Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
225                 230                 235                 240 


Ser Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala 
                245                 250                 255     


His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
                325                 330                 335     


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
    370                 375                 380                 


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
        435                 440                 445             


Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    450                 455                 460                 


Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg 
465                 470                 475                 480 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                485                 490                 495     


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
            500                 505                 510         


Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu His His 
        515                 520                 525             


His His His His 
    530         


<210>  220
<211>  1569
<212>  DNA
<213>  artificial

<220>
<223>  SA21-CD33 E11 HL x I2C HL

<400>  220
cgcctgattg aagatatttg cctgccgcgc tggggctgcc tgtgggaaga tgatcaggtg     60

cagctggtgc agtctggagc tgaggtgaag aagcctggag agtcagtcaa ggtctcctgc    120

aaggctagcg ggtatacctt cacaaactat ggaatgaact gggtgaagca ggctccagga    180

cagggtttag agtggatggg ctggataaac acctacactg gagagccaac ctatgctgat    240

aagttccagg gacgcgttac catgactacg gatacctcta ccagcactgc ctatatggaa    300

atccgcaacc tcggaggtga tgacacggct gtatattact gtgcgcgctg gagttggagt    360

gatggttact acgtttactt tgactactgg ggccaaggca cttcggtcac cgtctcctca    420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacat cgtgatgaca    480

cagtctccag actccctgac tgtgtctctg ggcgagagga ccaccatcaa ctgcaagtcc    540

agccagagtg ttttagacag ctccacgaat aagaactcct tagcttggta ccagcagaaa    600

ccaggacagc ctcctaaatt actcctttcc tgggcatcta cgcgggaatc cgggatccct    660

gaccgattca gtggcagcgg gtctgggaca gatttcactc tcactattga cagcccgcag    720

cctgaagatt ctgcaactta ctattgtcaa cagtctgccc acttcccgat cacctttggc    780

caagggacac gactggagat taaatccgga ggtggtggct ccgaggtgca gctggtcgag    840

tctggaggag gattggtgca gcctggaggg tcattgaaac tctcatgtgc agcctctgga    900

ttcaccttca ataagtacgc catgaactgg gtccgccagg ctccaggaaa gggtttggaa    960

tgggttgctc gcataagaag taaatataat aattatgcaa catattatgc cgattcagtg   1020

aaagacaggt tcaccatctc cagagatgat tcaaaaaaca ctgcctatct acaaatgaac   1080

aacttgaaaa ctgaggacac tgccgtgtac tactgtgtga gacatgggaa cttcggtaat   1140

agctacatat cctactgggc ttactggggc caagggactc tggtcaccgt ctcctcaggt   1200

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctcagactgt tgtgactcag   1260

gaaccttcac tcaccgtatc acctggtgga acagtcacac tcacttgtgg ctcctcgact   1320

ggggctgtta catctggcaa ctacccaaac tgggtccaac aaaaaccagg tcaggcaccc   1380

cgtggtctaa taggtgggac taagttcctc gcccccggta ctcctgccag attctcaggc   1440

tccctgcttg gaggcaaggc tgccctcacc ctctcagggg tacagccaga ggatgaggca   1500

gaatattact gtgttctatg gtacagcaac cgctgggtgt tcggtggagg aaccaaactg   1560

actgtccta                                                           1569


<210>  221
<211>  523
<212>  PRT
<213>  artificial

<220>
<223>  SA21-CD33 E11 HL x I2C HL

<400>  221

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            20                  25                  30          


Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              


Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp 
65                  70                  75                  80  


Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr 
                85                  90                  95      


Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile 
                165                 170                 175     


Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn 
            180                 185                 190         


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln 
225                 230                 235                 240 


Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro 
                245                 250                 255     


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        275                 280                 285             


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
    290                 295                 300                 


Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
            340                 345                 350         


Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
    370                 375                 380                 


Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr 
                405                 410                 415     


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
            420                 425                 430         


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
        435                 440                 445             


Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
    450                 455                 460                 


Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                485                 490                 495     


Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp 
            500                 505                 510         


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        515                 520             


<210>  222
<211>  1557
<212>  DNA
<213>  artificial

<220>
<223>  SA25-CD33 E11 HL x I2C HL

<400>  222
gaggacatct gcctgcccag atggggctgc ctgtgggagg accaggtgca gctggtgcag     60

tctggagctg aggtgaagaa gcctggagag tcagtcaagg tctcctgcaa ggctagcggg    120

tataccttca caaactatgg aatgaactgg gtgaagcagg ctccaggaca gggtttagag    180

tggatgggct ggataaacac ctacactgga gagccaacct atgctgataa gttccaggga    240

cgcgttacca tgactacgga tacctctacc agcactgcct atatggaaat ccgcaacctc    300

ggaggtgatg acacggctgt atattactgt gcgcgctgga gttggagtga tggttactac    360

gtttactttg actactgggg ccaaggcact tcggtcaccg tctcctcagg tggtggtggt    420

tctggcggcg gcggctccgg tggtggtggt tctgacatcg tgatgacaca gtctccagac    480

tccctgactg tgtctctggg cgagaggacc accatcaact gcaagtccag ccagagtgtt    540

ttagacagct ccacgaataa gaactcctta gcttggtacc agcagaaacc aggacagcct    600

cctaaattac tcctttcctg ggcatctacg cgggaatccg ggatccctga ccgattcagt    660

ggcagcgggt ctgggacaga tttcactctc actattgaca gcccgcagcc tgaagattct    720

gcaacttact attgtcaaca gtctgcccac ttcccgatca cctttggcca agggacacga    780

ctggagatta aatccggagg tggtggctcc gaggtgcagc tggtcgagtc tggaggagga    840

ttggtgcagc ctggagggtc attgaaactc tcatgtgcag cctctggatt caccttcaat    900

aagtacgcca tgaactgggt ccgccaggct ccaggaaagg gtttggaatg ggttgctcgc    960

ataagaagta aatataataa ttatgcaaca tattatgccg attcagtgaa agacaggttc   1020

accatctcca gagatgattc aaaaaacact gcctatctac aaatgaacaa cttgaaaact   1080

gaggacactg ccgtgtacta ctgtgtgaga catgggaact tcggtaatag ctacatatcc   1140

tactgggctt actggggcca agggactctg gtcaccgtct cctcaggtgg tggtggttct   1200

ggcggcggcg gctccggtgg tggtggttct cagactgttg tgactcagga accttcactc   1260

accgtatcac ctggtggaac agtcacactc acttgtggct cctcgactgg ggctgttaca   1320

tctggcaact acccaaactg ggtccaacaa aaaccaggtc aggcaccccg tggtctaata   1380

ggtgggacta agttcctcgc ccccggtact cctgccagat tctcaggctc cctgcttgga   1440

ggcaaggctg ccctcaccct ctcaggggta cagccagagg atgaggcaga atattactgt   1500

gttctatggt acagcaaccg ctgggtgttc ggtggaggaa ccaaactgac tgtccta      1557


<210>  223
<211>  519
<212>  PRT
<213>  artificial

<220>
<223>  SA25-CD33 E11 HL x I2C HL

<400>  223

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Gln Val 
1               5                   10                  15      


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Val 
            20                  25                  30          


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met 
        35                  40                  45              


Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
    50                  55                  60                  


Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe Gln Gly 
65                  70                  75                  80  


Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
                85                  90                  95      


Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
145                 150                 155                 160 


Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys Lys Ser 
                165                 170                 175     


Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser Trp Ala 
        195                 200                 205             


Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu Asp Ser 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 
    290                 295                 300                 


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
305                 310                 315                 320 


Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
            340                 345                 350         


Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                405                 410                 415     


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
            420                 425                 430         


Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 
    450                 455                 460                 


Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
465                 470                 475                 480 


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                485                 490                 495     


Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Leu Thr Val Leu 
        515                 


<210>  224
<211>  1578
<212>  DNA
<213>  artificial

<220>
<223>  SA08-CD33 E11 HL x I2C HL

<400>  224
cagggcctga tcggcgacat ctgcctgccc agatggggct gcctgtgggg cgactccgtg     60

aaacaggtgc agctggtgca gtctggagct gaggtgaaga agcctggaga gtcagtcaag    120

gtctcctgca aggctagcgg gtataccttc acaaactatg gaatgaactg ggtgaagcag    180

gctccaggac agggtttaga gtggatgggc tggataaaca cctacactgg agagccaacc    240

tatgctgata agttccaggg acgcgttacc atgactacgg atacctctac cagcactgcc    300

tatatggaaa tccgcaacct cggaggtgat gacacggctg tatattactg tgcgcgctgg    360

agttggagtg atggttacta cgtttacttt gactactggg gccaaggcac ttcggtcacc    420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttctgacatc    480

gtgatgacac agtctccaga ctccctgact gtgtctctgg gcgagaggac caccatcaac    540

tgcaagtcca gccagagtgt tttagacagc tccacgaata agaactcctt agcttggtac    600

cagcagaaac caggacagcc tcctaaatta ctcctttcct gggcatctac gcgggaatcc    660

gggatccctg accgattcag tggcagcggg tctgggacag atttcactct cactattgac    720

agcccgcagc ctgaagattc tgcaacttac tattgtcaac agtctgccca cttcccgatc    780

acctttggcc aagggacacg actggagatt aaatccggag gtggtggctc cgaggtgcag    840

ctggtcgagt ctggaggagg attggtgcag cctggagggt cattgaaact ctcatgtgca    900

gcctctggat tcaccttcaa taagtacgcc atgaactggg tccgccaggc tccaggaaag    960

ggtttggaat gggttgctcg cataagaagt aaatataata attatgcaac atattatgcc   1020

gattcagtga aagacaggtt caccatctcc agagatgatt caaaaaacac tgcctatcta   1080

caaatgaaca acttgaaaac tgaggacact gccgtgtact actgtgtgag acatgggaac   1140

ttcggtaata gctacatatc ctactgggct tactggggcc aagggactct ggtcaccgtc   1200

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tcagactgtt   1260

gtgactcagg aaccttcact caccgtatca cctggtggaa cagtcacact cacttgtggc   1320

tcctcgactg gggctgttac atctggcaac tacccaaact gggtccaaca aaaaccaggt   1380

caggcacccc gtggtctaat aggtgggact aagttcctcg cccccggtac tcctgccaga   1440

ttctcaggct ccctgcttgg aggcaaggct gccctcaccc tctcaggggt acagccagag   1500

gatgaggcag aatattactg tgttctatgg tacagcaacc gctgggtgtt cggtggagga   1560

accaaactga ctgtccta                                                 1578


<210>  225
<211>  526
<212>  PRT
<213>  artificial

<220>
<223>  SA08-CD33 E11 HL x I2C HL

<400>  225

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val Lys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg 
                165                 170                 175     


Thr Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr 
            180                 185                 190         


Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        195                 200                 205             


Lys Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
225                 230                 235                 240 


Ser Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala 
                245                 250                 255     


His Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
                325                 330                 335     


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
    370                 375                 380                 


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
        435                 440                 445             


Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    450                 455                 460                 


Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg 
465                 470                 475                 480 


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                485                 490                 495     


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
            500                 505                 510         


Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        515                 520                 525     


<210>  226
<211>  1533
<212>  DNA
<213>  artificial

<220>
<223>  CD33 E11 HL x I2C HL (His Tag)

<400>  226
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagagtc agtcaaggtc     60

tcctgcaagg ctagcgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggacagg gtttagagtg gatgggctgg ataaacacct acactggaga gccaacctat    180

gctgataagt tccagggacg cgttaccatg actacggata cctctaccag cactgcctat    240

atggaaatcc gcaacctcgg aggtgatgac acggctgtat attactgtgc gcgctggagt    300

tggagtgatg gttactacgt ttactttgac tactggggcc aaggcacttc ggtcaccgtc    360

tcctcaggtg gtggtggttc tggcggcggc ggctccggtg gtggtggttc tgacatcgtg    420

atgacacagt ctccagactc cctgactgtg tctctgggcg agaggaccac catcaactgc    480

aagtccagcc agagtgtttt agacagctcc acgaataaga actccttagc ttggtaccag    540

cagaaaccag gacagcctcc taaattactc ctttcctggg catctacgcg ggaatccggg    600

atccctgacc gattcagtgg cagcgggtct gggacagatt tcactctcac tattgacagc    660

ccgcagcctg aagattctgc aacttactat tgtcaacagt ctgcccactt cccgatcacc    720

tttggccaag ggacacgact ggagattaaa tccggaggtg gtggctccga ggtgcagctg    780

gtcgagtctg gaggaggatt ggtgcagcct ggagggtcat tgaaactctc atgtgcagcc    840

tctggattca ccttcaataa gtacgccatg aactgggtcc gccaggctcc aggaaagggt    900

ttggaatggg ttgctcgcat aagaagtaaa tataataatt atgcaacata ttatgccgat    960

tcagtgaaag acaggttcac catctccaga gatgattcaa aaaacactgc ctatctacaa   1020

atgaacaact tgaaaactga ggacactgcc gtgtactact gtgtgagaca tgggaacttc   1080

ggtaatagct acatatccta ctgggcttac tggggccaag ggactctggt caccgtctcc   1140

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca gactgttgtg   1200

actcaggaac cttcactcac cgtatcacct ggtggaacag tcacactcac ttgtggctcc   1260

tcgactgggg ctgttacatc tggcaactac ccaaactggg tccaacaaaa accaggtcag   1320

gcaccccgtg gtctaatagg tgggactaag ttcctcgccc ccggtactcc tgccagattc   1380

tcaggctccc tgcttggagg caaggctgcc ctcaccctct caggggtaca gccagaggat   1440

gaggcagaat attactgtgt tctatggtac agcaaccgct gggtgttcgg tggaggaacc   1500

aaactgactg tcctacatca ccatcaccat cac                                1533


<210>  227
<211>  511
<212>  PRT
<213>  artificial

<220>
<223>  CD33 E11 HL x I2C HL H6

<400>  227

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu His His His His His His 
            500                 505                 510     


