               SEQUENCE LISTING

<110> Lanxess Deutschland GmbH

<120> Verkettung von halogenierten Alkenyldiphosphat-Derivaten

<130> P60385WO

<150> EP13184167.8
<151> 2013-09-12

<160> 9

<170> BiSSAP 1.3

<210> 1
<211> 253
<212> PRT
<213> Escherichia coli

<400> 1
Met Met Leu Ser Ala Thr Gln Pro Leu Ser Glu Lys Leu Pro Ala His 
1               5                   10                  15      
Gly Cys Arg His Val Ala Ile Ile Met Asp Gly Asn Gly Arg Trp Ala 
            20                  25                  30          
Lys Lys Gln Gly Lys Ile Arg Ala Phe Gly His Lys Ala Gly Ala Lys 
        35                  40                  45              
Ser Val Arg Arg Ala Val Ser Phe Ala Ala Asn Asn Gly Ile Glu Ala 
    50                  55                  60                  
Leu Thr Leu Tyr Ala Phe Ser Ser Glu Asn Trp Asn Arg Pro Ala Gln 
65                  70                  75                  80  
Glu Val Ser Ala Leu Met Glu Leu Phe Val Trp Ala Leu Asp Ser Glu 
                85                  90                  95      
Val Lys Ser Leu His Arg His Asn Val Arg Leu Arg Ile Ile Gly Asp 
            100                 105                 110         
Thr Ser Arg Phe Asn Ser Arg Leu Gln Glu Arg Ile Arg Lys Ser Glu 
        115                 120                 125             
Ala Leu Thr Ala Gly Asn Thr Gly Leu Thr Leu Asn Ile Ala Ala Asn 
    130                 135                 140                 
Tyr Gly Gly Arg Trp Asp Ile Val Gln Gly Val Arg Gln Leu Ala Glu 
145                 150                 155                 160 
Lys Val Gln Gln Gly Asn Leu Gln Pro Asp Gln Ile Asp Glu Glu Met 
                165                 170                 175     
Leu Asn Gln His Val Cys Met His Glu Leu Ala Pro Val Asp Leu Val 
            180                 185                 190         
Ile Arg Thr Gly Gly Glu His Arg Ile Ser Asn Phe Leu Leu Trp Gln 
        195                 200                 205             
Ile Ala Tyr Ala Glu Leu Tyr Phe Thr Asp Val Leu Trp Pro Asp Phe 
    210                 215                 220                 
Asp Glu Gln Asp Phe Glu Gly Ala Leu Asn Ala Phe Ala Asn Arg Glu 
225                 230                 235                 240 
Arg Arg Phe Gly Gly Thr Glu Pro Gly Asp Glu Thr Ala 
                245                 250             

<210> 2
<211> 264
<212> PRT
<213> Thermococcus kodakaraensis

<400> 2
Met Leu Tyr Arg Leu Val Ser His Ile Pro His Ile Leu Phe Lys Pro 
1               5                   10                  15      
Val Tyr Asp Ala Tyr Glu Ser Tyr Leu Leu Glu Lys Val Lys Ser Gly 
            20                  25                  30          
Asn Ile Pro Lys His Val Ala Ile Ile Met Asp Gly Asn Arg Arg Trp 
        35                  40                  45              
Ala Arg Lys Leu Glu Lys Pro Pro Trp Tyr Gly His Leu Phe Gly Ser 
    50                  55                  60                  
Lys Lys Leu Glu Glu Ile Leu Glu Trp Cys Arg Glu Leu Asn Ile Arg 
65                  70                  75                  80  
Thr Leu Thr Val Tyr Ala Phe Ser Thr Glu Asn Phe Lys Arg Ser Lys 
                85                  90                  95      
Glu Glu Val Glu Ala Leu Met Asn Leu Phe Glu Glu Lys Phe Lys Glu 
            100                 105                 110         
Leu Val Gln Asp Glu Arg Val His Arg Tyr Gly Ile Arg Val Asn Val 
        115                 120                 125             
Leu Gly Arg Lys Asp Met Leu Pro Glu Asn Val Arg Lys Ala Ala Glu 
    130                 135                 140                 
Glu Ala Glu Arg Ala Thr Arg Lys Tyr Ser Asn Tyr Asn Leu Asn Ile 
145                 150                 155                 160 
Ala Leu Ala Tyr Gly Gly Arg Ser Glu Ile Ala Asp Ala Val Arg Glu 
                165                 170                 175     
Ile Val Arg Asp Val Leu Glu Gly Lys Ile Lys Pro Glu Asp Ile Asp 
            180                 185                 190         
Glu Glu Ala Ile Lys Arg Tyr Leu Tyr Tyr Pro Asn Met Pro Asp Pro 
        195                 200                 205             
Asp Ile Val Ile Arg Thr Gly Gly Glu Val Arg Ile Ser Asn Phe Leu 
    210                 215                 220                 
Leu Tyr Gln Ile Ala Tyr Ser Glu Leu Phe Phe Val Asp Val Tyr Phe 
225                 230                 235                 240 
Pro Glu Phe Arg Lys Ile Asp Phe Leu Arg Ile Ile Arg Glu Phe Gln 
                245                 250                 255     
Lys Arg Gln Arg Arg Phe Gly Arg 
            260                 

<210> 3
<211> 249
<212> PRT
<213> Micrococcus luteus

<400> 3
Met Phe Pro Ile Lys Lys Arg Lys Ala Ile Lys Asn Asn Asn Ile Asn 
1               5                   10                  15      
Ala Ala Gln Ile Pro Lys His Ile Ala Ile Ile Met Asp Gly Asn Gly 
            20                  25                  30          
Arg Trp Ala Lys Gln Lys Lys Met Pro Arg Ile Lys Gly His Tyr Glu 
        35                  40                  45              
Gly Met Gln Thr Val Lys Lys Ile Thr Arg Tyr Ala Ser Asp Leu Gly 
    50                  55                  60                  
Val Lys Tyr Leu Thr Leu Tyr Ala Phe Ser Thr Glu Asn Trp Ser Arg 
65                  70                  75                  80  
Pro Lys Asp Glu Val Asn Tyr Leu Met Lys Leu Pro Gly Asp Phe Leu 
                85                  90                  95      
Asn Thr Phe Leu Pro Glu Leu Ile Glu Lys Asn Val Lys Val Glu Thr 
            100                 105                 110         
Ile Gly Phe Ile Asp Asp Leu Pro Asp His Thr Lys Lys Ala Val Leu 
        115                 120                 125             
Glu Ala Lys Glu Lys Thr Lys His Asn Thr Gly Leu Thr Leu Val Phe 
    130                 135                 140                 
Ala Leu Asn Tyr Gly Gly Arg Lys Glu Ile Ile Ser Ala Val Gln Leu 
145                 150                 155                 160 
Ile Ala Glu Arg Tyr Lys Ser Gly Glu Ile Ser Leu Asp Glu Ile Ser 
                165                 170                 175     
Glu Thr His Phe Asn Glu Tyr Leu Phe Thr Ala Asn Met Pro Asp Pro 
            180                 185                 190         
Glu Leu Leu Ile Arg Thr Ser Gly Glu Glu Arg Leu Ser Asn Phe Leu 
        195                 200                 205             
Ile Trp Gln Cys Ser Tyr Ser Glu Phe Val Phe Ile Asp Glu Phe Trp 
    210                 215                 220                 
Pro Asp Phe Asn Glu Glu Ser Leu Ala Gln Cys Ile Ser Ile Tyr Gln 
225                 230                 235                 240 
Asn Arg His Arg Arg Phe Gly Gly Leu 
                245                 

<210> 4
<211> 296
<212> PRT
<213> Mycobacterium tuberculosis

<400> 4
Met Ala Arg Asp Ala Arg Lys Arg Thr Ser Ser Asn Phe Pro Gln Leu 
1               5                   10                  15      
Pro Pro Ala Pro Asp Asp Tyr Pro Thr Phe Pro Asp Thr Ser Thr Trp 
            20                  25                  30          
Pro Val Val Phe Pro Glu Leu Pro Ala Ala Pro Tyr Gly Gly Pro Cys 
        35                  40                  45              
Arg Pro Pro Gln His Thr Ser Lys Ala Ala Ala Pro Arg Ile Pro Ala 
    50                  55                  60                  
Asp Arg Leu Pro Asn His Val Ala Ile Val Met Asp Gly Asn Gly Arg 
65                  70                  75                  80  
Trp Ala Thr Gln Arg Gly Leu Ala Arg Thr Glu Gly His Lys Met Gly 
                85                  90                  95      
Glu Ala Val Val Ile Asp Ile Ala Cys Gly Ala Ile Glu Leu Gly Ile 
            100                 105                 110         
Lys Trp Leu Ser Leu Tyr Ala Phe Ser Thr Glu Asn Trp Lys Arg Ser 
        115                 120                 125             
Pro Glu Glu Val Arg Phe Leu Met Gly Phe Asn Arg Asp Val Val Arg 
    130                 135                 140                 
Arg Arg Arg Asp Thr Leu Lys Lys Leu Gly Val Arg Ile Arg Trp Val 
145                 150                 155                 160 
Gly Ser Arg Pro Arg Leu Trp Arg Ser Val Ile Asn Glu Leu Ala Val 
                165                 170                 175     
Ala Glu Glu Met Thr Lys Ser Asn Asp Val Ile Thr Ile Asn Tyr Cys 
            180                 185                 190         
Val Asn Tyr Gly Gly Arg Thr Glu Ile Thr Glu Ala Thr Arg Glu Ile 
        195                 200                 205             
Ala Arg Glu Val Ala Ala Gly Arg Leu Asn Pro Glu Arg Ile Thr Glu 
    210                 215                 220                 
Ser Thr Ile Ala Arg His Leu Gln Arg Pro Asp Ile Pro Asp Val Asp 
225                 230                 235                 240 
Leu Phe Leu Arg Thr Ser Gly Glu Gln Arg Ser Ser Asn Phe Met Leu 
                245                 250                 255     
Trp Gln Ala Ala Tyr Ala Glu Tyr Ile Phe Gln Asp Lys Leu Trp Pro 
            260                 265                 270         
Asp Tyr Asp Arg Arg Asp Leu Trp Ala Ala Cys Glu Glu Tyr Ala Ser 
        275                 280                 285             
Arg Thr Arg Arg Phe Gly Ser Ala 
    290                 295     

<210> 5
<211> 234
<212> PRT
<213> Helicobacter pylori

<400> 5
Met Asp Asn Thr Leu Lys His Leu Ala Ile Ile Met Asp Gly Asn Gly 
1               5                   10                  15      
Arg Trp Ala Lys Leu Lys Asn Lys Ala Arg Ala Tyr Gly His Lys Lys 
            20                  25                  30          
Gly Val Lys Thr Leu Lys Asp Ile Thr Ile Trp Cys Ala Asn His Lys 
        35                  40                  45              
Leu Glu Cys Leu Thr Leu Tyr Ala Phe Ser Thr Glu Asn Trp Lys Arg 
    50                  55                  60                  
Pro Lys Ser Glu Val Asp Phe Leu Met Lys Met Leu Lys Lys Tyr Leu 
65                  70                  75                  80  
Lys Asp Glu Arg Ser Thr Tyr Leu Asn Asn Asn Ile Arg Phe Arg Ala 
                85                  90                  95      
Ile Gly Asp Leu Glu Gly Phe Ser Lys Glu Leu Arg Asp Thr Ile Leu 
            100                 105                 110         
Gln Leu Glu Asn Asp Thr Arg His Phe Lys Asp Phe Thr Gln Val Leu 
        115                 120                 125             
Ala Leu Asn Tyr Gly Ser Lys Asn Glu Leu Ser Arg Ala Phe Lys Ser 
    130                 135                 140                 
Leu Leu Glu Ser Pro Pro Ser His Ile Asn Leu Leu Glu Ser Leu Glu 
145                 150                 155                 160 
Asn Glu Ile Ser Asn Arg Leu Asp Thr His Asp Leu Pro Glu Val Asp 
                165                 170                 175     
Leu Leu Leu Arg Thr Gly Gly Glu Met Arg Leu Ser Asn Phe Leu Leu 
            180                 185                 190         
Trp Gln Ser Ser Tyr Ala Glu Leu Phe Phe Thr Pro Ile Leu Trp Pro 
        195                 200                 205             
Asp Phe Thr Pro Lys Asp Leu Glu Asn Ile Ile Ser Asp Phe Tyr Lys 
    210                 215                 220                 
Arg Val Arg Lys Phe Gly Glu Leu Lys Cys 
225                 230                 

<210> 6
<211> 333
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Trp Ile Lys Glu Gly Glu Leu Ser Leu Trp Glu Arg Phe Cys 
1               5                   10                  15      
Ala Asn Ile Ile Lys Ala Gly Pro Met Pro Lys His Ile Ala Phe Ile 
            20                  25                  30          
Met Asp Gly Asn Arg Arg Tyr Ala Lys Lys Cys Gln Val Glu Arg Gln 
        35                  40                  45              
Glu Gly His Ser Gln Gly Phe Asn Lys Leu Ala Glu Thr Leu Arg Trp 
    50                  55                  60                  
Cys Leu Asn Leu Gly Ile Leu Glu Val Thr Val Tyr Ala Phe Ser Ile 
65                  70                  75                  80  
Glu Asn Phe Lys Arg Ser Lys Ser Glu Val Asp Gly Leu Met Asp Leu 
                85                  90                  95      
Ala Arg Gln Lys Phe Ser Arg Leu Met Glu Glu Lys Glu Lys Leu Gln 
            100                 105                 110         
Lys His Gly Val Cys Ile Arg Val Leu Gly Asp Leu His Leu Leu Pro 
        115                 120                 125             
Leu Asp Leu Gln Glu Leu Ile Ala Gln Ala Val Gln Ala Thr Lys Asn 
    130                 135                 140                 
Tyr Asn Lys Cys Phe Leu Asn Val Cys Phe Ala Tyr Thr Ser Arg His 
145                 150                 155                 160 
Glu Ile Ser Asn Ala Val Arg Glu Met Ala Trp Gly Val Glu Gln Gly 
                165                 170                 175     
Leu Leu Asp Pro Ser Asp Ile Ser Glu Ser Leu Leu Asp Lys Cys Leu 
            180                 185                 190         
Tyr Thr Asn Arg Ser Pro His Pro Asp Ile Leu Ile Arg Thr Ser Gly 
        195                 200                 205             
Glu Val Arg Leu Ser Asp Phe Leu Leu Trp Gln Thr Ser His Ser Cys 
    210                 215                 220                 
Leu Val Phe Gln Pro Val Leu Trp Pro Glu Tyr Thr Phe Trp Asn Leu 
225                 230                 235                 240 
Phe Glu Ala Ile Leu Gln Phe Gln Met Asn His Ser Val Leu Gln Lys 
                245                 250                 255     
Ala Arg Asp Met Tyr Ala Glu Glu Arg Lys Arg Gln Gln Leu Glu Arg 
            260                 265                 270         
Asp Gln Ala Thr Val Thr Glu Gln Leu Leu Arg Glu Gly Leu Gln Ala 
        275                 280                 285             
Ser Gly Asp Ala Gln Leu Arg Arg Thr Arg Leu His Lys Leu Ser Ala 
    290                 295                 300                 
Arg Arg Glu Glu Arg Val Gln Gly Phe Leu Gln Ala Leu Glu Leu Lys 
305                 310                 315                 320 
Arg Ala Asp Trp Leu Ala Arg Leu Gly Thr Ala Ser Ala 
                325                 330             

<210> 7
<211> 284
<212> PRT
<213> Hevea brasiliensis

<400> 7
Met Glu Leu Tyr Asn Gly Glu Arg Pro Ser Val Phe Arg Leu Leu Gly 
1               5                   10                  15      
Lys Tyr Met Arg Lys Gly Leu Tyr Ser Ile Leu Thr Gln Gly Pro Ile 
            20                  25                  30          
Pro Thr His Ile Ala Phe Ile Leu Asp Gly Asn Gly Arg Phe Ala Lys 
        35                  40                  45              
Lys His Lys Leu Pro Glu Gly Gly Gly His Lys Ala Gly Phe Leu Ala 
    50                  55                  60                  
Leu Leu Asn Val Leu Thr Tyr Cys Tyr Glu Leu Gly Val Lys Tyr Ala 
65                  70                  75                  80  
Thr Ile Tyr Ala Phe Ser Ile Asp Asn Phe Arg Arg Lys Pro His Glu 
                85                  90                  95      
Val Gln Tyr Val Met Asn Leu Met Leu Glu Lys Ile Glu Gly Met Ile 
            100                 105                 110         
Met Glu Glu Ser Ile Ile Asn Ala Tyr Asp Ile Cys Val Arg Phe Val 
        115                 120                 125             
Gly Asn Leu Lys Leu Leu Asp Glu Pro Leu Lys Thr Ala Ala Asp Lys 
    130                 135                 140                 
Ile Met Arg Ala Thr Ala Lys Asn Ser Lys Phe Val Leu Leu Leu Ala 
145                 150                 155                 160 
Val Cys Tyr Thr Ser Thr Asp Glu Ile Val His Ala Val Glu Glu Ser 
                165                 170                 175     
Ser Lys Asp Lys Leu Lys Ser Asp Glu Ile Cys Asn Asp Gly Asn Gly 
            180                 185                 190         
Asp Cys Val Ile Lys Ile Glu Glu Met Glu Pro Tyr Ser Glu Ile Lys 
        195                 200                 205             
Leu Val Glu Leu Glu Arg Asn Thr Tyr Ile Asn Pro Tyr Pro Asp Val 
    210                 215                 220                 
Leu Ile Arg Thr Ser Gly Glu Thr Arg Leu Ser Asn Tyr Leu Leu Trp 
225                 230                 235                 240 
Gln Thr Thr Asn Cys Ile Leu Tyr Ser Pro His Ala Leu Trp Pro Glu 
                245                 250                 255     
Ile Gly Leu Arg His Val Val Trp Ala Val Ile Asn Cys Gln Arg His 
            260                 265                 270         
Tyr Ser Tyr Leu Glu Lys His Lys Glu Tyr Leu Lys 
        275                 280                 

<210> 8
<211> 308
<212> PRT
<213> Taraxacum koksaghyz

<400> 8
Met Gln Val Asn Pro Ile Ile Thr Thr Asp Ser Ser Leu Lys Leu Val 
1               5                   10                  15      
Glu Glu Glu Arg Ser Asn Gly Arg Ile Gly Asn Phe Leu Gly Gly Leu 
            20                  25                  30          
Asn Ala Thr Leu Arg Lys Leu Val Phe Arg Val Ile Ala Ser Arg Pro 
        35                  40                  45              
Ile Pro Glu His Ile Ala Phe Ile Leu Asp Gly Asn Arg Arg Phe Ala 
    50                  55                  60                  
Arg Lys Trp Asn Leu Thr Glu Gly Thr Gly His Lys Thr Gly Phe Leu 
65                  70                  75                  80  
Ala Leu Met Ser Val Leu Lys Tyr Cys Tyr Glu Ile Gly Val Lys Tyr 
                85                  90                  95      
Val Thr Ile Tyr Ala Phe Ser Leu Asp Asn Phe Asn Arg Arg Pro Asp 
            100                 105                 110         
Glu Val Gln Tyr Val Met Asp Leu Met Gln Asp Lys Ile Glu Gly Phe 
        115                 120                 125             
Leu Lys Glu Val Ser Ile Ile Asn Gln Tyr Gly Val Arg Val Leu Phe 
    130                 135                 140                 
Ile Gly Asp Leu Asp Arg Leu Tyr Glu Pro Val Arg Ile Ala Ala Glu 
145                 150                 155                 160 
Lys Ala Met Glu Ala Thr Ala Lys Asn Ser Thr Thr Tyr Leu Leu Val 
                165                 170                 175     
Cys Val Ala Tyr Thr Ser Ser His Glu Ile Pro Arg Ala Ile His Glu 
            180                 185                 190         
Ala Cys Glu Glu Lys Ser Gly Ala Met Ala Asn Ser Ile Arg Val Met 
        195                 200                 205             
Asn Gly Asn Gly Phe Phe Asn Gly Asn Gly Tyr Thr Asn Val Asn His 
    210                 215                 220                 
Gly Ser Gln Ala Val Ile Lys Val Val Asp Leu Asp Lys His Met Tyr 
225                 230                 235                 240 
Met Gly Val Ala Pro Asp Pro Asp Ile Leu Val Arg Ser Ser Gly Glu 
                245                 250                 255     
Thr Arg Leu Ser Asn Phe Leu Leu Trp Gln Thr Thr Asn Cys Leu Leu 
            260                 265                 270         
Tyr Ser Pro Lys Ala Leu Trp Pro Glu Met Gly Phe Trp Gln Val Val 
        275                 280                 285             
Trp Gly Ile Leu Glu Phe Gln Asn Asn Tyr Asn Tyr Leu Glu Lys Lys 
    290                 295                 300                 
Lys Lys Gln Ala 
305             

<210> 9
<211> 303
<212> PRT
<213> Arabidopsis thaliana

<400> 9
Met Leu Ser Leu Leu Ser Ser Asp Ser Ser Leu Leu Ser Leu Leu Phe 
1               5                   10                  15      
Leu Phe Leu Ile Pro Cys Leu Phe Ile Thr Ser Tyr Ile Gly Phe Pro 
            20                  25                  30          
Val Phe Leu Leu Lys Leu Ile Gly Leu Ile Lys Ile Lys Ala Ala Arg 
        35                  40                  45              
Asp Asn Glu Lys Arg Asp Glu Gly Thr Tyr Val Val Arg Glu Asp Gly 
    50                  55                  60                  
Leu Gln Arg Glu Leu Met Pro Arg His Val Ala Phe Ile Leu Asp Gly 
65                  70                  75                  80  
Asn Arg Arg Trp Ala Lys Arg Ala Gly Leu Thr Thr Ser Gln Gly His 
                85                  90                  95      
Glu Ala Gly Ala Lys Arg Leu Ile Asp Ile Ala Glu Leu Cys Phe Glu 
            100                 105                 110         
Leu Gly Val His Thr Val Ser Ala Phe Ala Phe Ser Thr Glu Asn Trp 
        115                 120                 125             
Gly Arg Asp Lys Ile Glu Ile Asp Asn Leu Met Ser Leu Ile Gln His 
    130                 135                 140                 
Tyr Arg Asn Lys Ser Asn Ile Lys Phe Phe His Arg Ser Glu Val Arg 
145                 150                 155                 160 
Val Ser Val Ile Gly Asn Lys Thr Lys Ile Pro Glu Ser Leu Leu Lys 
                165                 170                 175     
Glu Ile His Glu Ile Glu Glu Ala Thr Lys Gly Tyr Lys Asn Lys His 
            180                 185                 190         
Leu Ile Met Ala Val Asp Tyr Ser Gly Lys Phe Asp Ile Met His Ala 
        195                 200                 205             
Cys Lys Ser Leu Val Lys Lys Ser Glu Lys Gly Leu Ile Arg Glu Glu 
    210                 215                 220                 
Asp Val Asp Glu Ala Leu Ile Glu Arg Glu Leu Leu Thr Asn Cys Ser 
225                 230                 235                 240 
Asp Phe Pro Ser Pro Asp Leu Met Ile Arg Thr Ser Gly Glu Gln Arg 
                245                 250                 255     
Ile Ser Asn Phe Phe Leu Trp Gln Leu Ala Tyr Ser Glu Leu Phe Phe 
            260                 265                 270         
Ser Pro Val Phe Trp Pro Asp Phe Asp Lys Asp Lys Leu Leu Glu Ala 
        275                 280                 285             
Leu Ala Ser Tyr Gln Arg Arg Glu Arg Arg Phe Gly Cys Arg Val 
    290                 295                 300             

