                         SEQUENCE LISTING

<110>  Sarepta Therapeutics
       Wilton, Donald Stephen
       Fletcher, Sue
       
<120>  ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE

<130>  SATH-001/02WO

<150>  US 61/874,261
<151>  2013-09-05

<150>  US 61/932,195
<151>  2014-01-27

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  2664
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2652)..(2652)
<223>  n is t or u

<400>  1
gtgagacacc tgacgtctgc cccgcgctgc cggcggtaac atcccagaag cgggtttgaa       60

cgtgcctagc cgtgccccca gcctcttccc ctgagcggag cttgagcccc agacctctag      120

tcctcccggt ctttatctga gttcagctta gagatgaacg gggagccgcc ctcctgtgct      180

gggcttgggg ctggaggctg catcttcccg tttctagggt ttcctttccc cttttgatcg      240

acgcagtgct cagtcctggc cgggacccga gccacctctc ctgctcctgc aggacgcaca      300

tggctgggtc tgaatccctg gggtgaggag caccgtggcc tgagaggggg cccctgggcc      360

agctctgaaa tctgaatgtc tcaatcacaa agaccccctt aggccaggcc aggggtgact      420

gtctctggtc tttgtccctg gttgctggca catagcaccc gaaacccttg gaaaccgagt      480

gatgagagag ccttttgctc atgaggtgac tgatgaccgg ggacaccagg tggcttcagg      540

atggaagcag atggccagaa agaccaaggc ctgatgacgg gttgggatgg aaaaggggtg      600

aggggctgga gattgagtga atcaccagtg gcttagtcaa ccatgcctgc acaatggaac      660

cccgtaagaa accacaggga tcagagggct tcccgccggg ttgtggaaca caccaaggca      720

ctggagggtg gtgcgagcag agagcacagc atcactgccc ccacctcaca ccaggcccta      780

cgcatctctt ccatacggct gtctgagttt tatcctttgt aataaaccag caactgtaag      840

aaacgcactt tcctgagttc tgtgaccctg aagagggagt cctgggaacc tctgaattta      900

taactagttg atcgaaagta caagtgacaa cctgggattt gccattggcc tctgaagtga      960

aggcagtgtt gtgggactga gcccttaacc tgtggagtct gtgctgactc caggtagtgt     1020

caagattgaa ttgaattgta ggacacccag ccgtgtccag aaagttgcag aattgatggg     1080

tgtgagaaaa accctacaca tttaatgtca gaagtgtggg taaaatgttt caccctccag     1140

cccagagagc cctaatttac cagtggccca cggtggaaca ccacgtccgg ccgggggcag     1200

agcgttccca gccaagcctt ctgtaacatg acatgacagg tcagactccc tcgggccctg     1260

agttcacttc ttcctggtat gtgaccagct cccagtacca gagaaggttg cacagtcctc     1320

tgctccaagg agcttcactg gccaggggct gctttctgaa atccttgcct gcctctgctc     1380

caaggcccgt tcctcagaga cgcagacccc tctgatggct gactttggtt tgaggacctc     1440

tctgcatccc tcccccatgg ccttgctcct aggacacctt cttcctcctt tccctggggt     1500

cagacttgcc taggtgcggt ggctctccca gccttcccca cgccctcccc atggtgtatt     1560

acacacacca aagggactcc cctattgaaa tccatgcata ttgaatcgca tgtgggttcc     1620

ggctgctcct gggaggagcc aggctaatag aatgtttgcc ataaaatatt aatgtacaga     1680

gaagcgaaac aaaggtcgtt ggtacttgtt aaccttacca gcagaataat gaaagcgaac     1740

ccccatatct catctgcacg cgacatcctt gttgtgtctg tacccgaggc tccaggtgca     1800

gccactgtta cagagactgt gtttcttccc catgtacctc gggggccggg aggggttctg     1860

atctgcaaag tcgccagagg ttaagtcctt tctctcttgt ggctttgcca cccctggagt     1920

gtcaccctca gctgcggtgc ccaggattcc ccactgtggt atgtccgtgc accagtcaat     1980

aggaaaggga gcaaggaaag gtactgggtc cccctaagga catacgagtt gccagaatca     2040

cttccgctga cacccagtgg accaagccgc acctttatgc agaagtgggg ctcccagcca     2100

ggcgtggtca ctcctgaaat cccagcactt cggaaggcca aggggggtgg atcacttgag     2160

ctcaggagtt cgagaccagc ctgggtaaca tggcaaaatc ccgtctctac aaaaatacag     2220

aaaattagct gggtgcggtg gtgtgtgcct acagtcccag ctactcagga ggctgaagtg     2280

ggaggattgc ttgagtctgg gaggtggagg ttgcagtgag ccaggatctc accacagcac     2340

tctggcccag gcgacagctg tttggcctgt ttcaagtgtc tacctgcctt gctggtcttc     2400

ctggggacat tctaagcgtg tttgatttgt aacattttag cagactgtgc aagtgctctg     2460

cactcccctg ctggagcttt tctcgccctt ccttctggcc ctctccccag tctagacagc     2520

agggcaacac ccaccctggc caccttaccc cacctgcctg ggtgctgcag tgccagccgc     2580

ggttgatgtc tcagagctgc tttgagagcc ccgtgagtgc cgcccctccc gcctccctgc     2640

tgagcccgct tncttctccc gcag                                            2664


<210>  2
<211>  578
<212>  DNA
<213>  Homo sapiens

<400>  2
gcctgtagga gctgtccagg ccatctccaa ccatgggagt gaggcacccg ccctgctccc       60

accggctcct ggccgtctgc gccctcgtgt ccttggcaac cgctgcactc ctggggcaca      120

tcctactcca tgatttcctg ctggttcccc gagagctgag tggctcctcc ccagtcctgg      180

aggagactca cccagctcac cagcagggag ccagcagacc agggccccgg gatgcccagg      240

cacaccccgg ccgtcccaga gcagtgccca cacagtgcga cgtccccccc aacagccgct      300

tcgattgcgc ccctgacaag gccatcaccc aggaacagtg cgaggcccgc ggctgttgct      360

acatccctgc aaagcagggg ctgcagggag cccagatggg gcagccctgg tgcttcttcc      420

cacccagcta ccccagctac aagctggaga acctgagctc ctctgaaatg ggctacacgg      480

ccaccctgac ccgtaccacc cccaccttct tccccaagga catcctgacc ctgcggctgg      540

acgtgatgat ggagactgag aaccgcctcc acttcacg                              578


<210>  3
<211>  616
<212>  DNA
<213>  Homo sapiens

<400>  3
gtgggcaggg caggggcggg ggcggcggcc agggcagagg gtgcgcgtgg acatcgacac       60

ccacgcacct cacaagggtg gggtgcatgt tgcaccactg tgtgctgggc ccttgctggg      120

agcggaggtg tgagcagaca atggcagcgc ccctcgggga gcagtgggga caccacggtg      180

acaggtactc cagaaggcag ggctcggggc tcattcatct ttatgaaaag gtgggtcagg      240

tagagtaggg ctgccagagg ttgcgaatga aaacaggatg cccagtaaac ccgaattgca      300

gataccccag gcatgacttt gtttttttgt gtaaggatgc aaaatttggg atgtatttat      360

actagaaaag ctgcttgttg tttatctgaa attcagagtt atcaggtgtt ctgtatttta      420

cctccatcct gggggaggcg tcctcctcct ggctctgcag atgagggagc cgaggctcag      480

agaggctgaa tgtgctgccc atggtcccac atccatgtgt ggctgcacca ggacctgacc      540

tgtccttggc gtgcgggttg ttctctggag agtaaggtgg ctgtggggaa catcaataaa      600

cccccatctc ttctag                                                      616


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<400>  4
gcncagcagg gaggcgggag                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  5
ggcncncaaa gcagcncnga                                                   20


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<400>  6
gacancaacc gcggcnggca cngca                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is t or u

<400>  7
gggnaaggng gccagggngg gngnn                                             25


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  8
gcccngcngn cnagacngg                                                    19


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence

<400>  9
gagagggcca gaaggaaggg                                                   20


<210>  10
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<400>  10
cccgccccng cccngcc                                                      17


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<400>  11
nggccgccgc ccccgccc                                                     18


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  12
ngnccacgcg cacccncngc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  13
gngaggngcg ngggngncga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is t or u

<400>  14
gcaacangca ccccacccnn                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  15
agggcccagc acacagnggn                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<400>  16
ncacaccncc gcncccagca                                                   20


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<400>  17
ggcgcngcca nngncngc                                                     18


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<400>  18
gngnccccac ngcnccccga                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  19
cnggagnacc ngncaccgng                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is t or u

<400>  20
ngagccccga gcccngccnn                                                   20


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<400>  21
ngacccaccn nnncanaaag angaa                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<400>  22
cncnggcagc ccnacncnac cngac                                             25


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(25)
<223>  n is t or u

<400>  23
cnagnanaaa nacancccaa annnngc                                           27


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA exon 2 targeting sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is t or u

<400>  24
ggcccnggnc ngcnggcncc cngcn                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA exon 2 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n is t or u

<400>  25
gcncccngca gccccngcnn ngcag                                             25


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  26
ggggcagacg ncaggngncn                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  27
gcggggcaga cgncaggngn                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  28
gcgcggggca gacgncaggn                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  29
cagcgcgggg cagacgncag                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  30
ggcagcgcgg ggcagacgnc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence

<400>  31
ccggcagcgc ggggcagacg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence

<400>  32
gccggcagcg cggggcagac                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence

<400>  33
ccgccggcag cgcggggcag                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is t or u

<400>  34
gnnaccgccg gcagcgcggg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is t or u

<400>  35
gangnnaccg ccggcagcgc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is t or u

<400>  36
gggangnnac cgccggcagc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is t or u

<400>  37
cngggangnn accgccggca                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is t or u

<400>  38
nncngggang nnaccgccgg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is t or u

<400>  39
gcnncnggga ngnnaccgcc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is t or u

<400>  40
gcaacncgna ngnccnnagg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is t or u

<400>  41
nggcaacncg nangnccnna                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  42
ncnggcaacn cgnangnccn                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  43
anncnggcaa cncgnangnc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  44
gnganncngg caacncgnan                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  45
aagnganncn ggcaacncgn                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  46
ngggngncag cggaagngan                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<400>  47
ccacngggng ncagcggaag                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<400>  48
gnccacnggg ngncagcgga                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<400>  49
nggnccacng ggngncagcg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  50
gcnnggncca cngggngnca                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  51
ccacnncngc anaaaggngc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  52
ccccacnncn gcanaaaggn                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<400>  53
agccccacnn cngcanaaag                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  54
ggagccccac nncngcanaa                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  55
ngggagcccc acnncngcan                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  56
gcngggagcc ccacnncngc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  57
nggcngggag ccccacnncn                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<400>  58
ccacgccngg cngggagccc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  n is t or u

<400>  59
nccgaagngc ngggannnca                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is t or u

<400>  60
nccacccccc nnggccnncc                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  61
nganccaccc cccnnggccn                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is t or u

<400>  62
ncaagnganc caccccccnn                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<400>  63
agcncaagng anccaccccc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  64
gaacnccnga gcncaagnga                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  65
ncncgaacnc cngagcncaa                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  66
aggcnggncn cgaacnccng                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  67
ccaggcnggn cncgaacncc                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  68
nnngccangn nacccaggcn                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is t or u

<400>  69
gggannnngc cangnnaccc                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is t or u

<400>  70
acgggannnn gccangnnac                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  71
gagacgggan nnngccangn                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  72
nagagacggg annnngccan                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is t or u

<400>  73
nnnngnagag acgggannnn                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<400>  74
ngnannnnng nagagacggg                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<400>  75
ncngnannnn ngnagagacg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<400>  76
nnncngnann nnngnagaga                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  77
annnncngna nnnnngnaga                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  78
naannnncng nannnnngna                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  n is t or u

<400>  79
gcnaannnnc ngnannnnng                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<400>  80
cccgccccng cccngcccac                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  81
ccgcccccgc cccngcccng                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  82
ccgccgcccc cgccccngcc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  83
nggccgccgc ccccgccccn                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<400>  84
cngcccnggc cgccgccccc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<400>  85
cacccncngc ccnggccgcc                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<400>  86
gcgcacccnc ngcccnggcc                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<400>  87
ngncgangnc cacgcgcacc                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<400>  88
gngggngncg angnccacgc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  89
ngcgngggng ncgangncca                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  90
gngaggngcg ngggngncga                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  91
gcaccccacc cnngngaggn                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  92
aacangcacc ccacccnngn                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<400>  93
aggaggagga cgccnccccc                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<400>  94
cncancngca gagccaggag                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<400>  95
cccncancng cagagccagg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<400>  96
cncccncanc ngcagagcca                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<400>  97
gcncccncan cngcagagcc                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<400>  98
ggcncccnca ncngcagagc                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<400>  99
cggcncccnc ancngcagag                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<400>  100
ncggcncccn cancngcaga                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<400>  101
cncggcnccc ncancngcag                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  102
ccncggcncc cncancngca                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA Intron 2 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  103
gccncggcnc ccncancngc                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  104
ggcncncaaa gcagcncnga                                                   20


<210>  105
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is t or u

<400>  105
ggcncncaaa gcagcncnga gacan                                             25


<210>  106
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is t or u

<400>  106
cacggggcnc ncaaagcagc ncnga                                             25


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is t or u

<400>  107
ncaaagcagc ncngagacan                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<400>  108
cacggggcnc ncaaagcagc                                                   20


<210>  109
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  109
gcccngcngn cnagacngg                                                    19


<210>  110
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  110
gcccngcngn cnagacnggg gaga                                              24


<210>  111
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<400>  111
gngnngcccn gcngncngga cngg                                              24


<210>  112
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<400>  112
gcngncnaga cnggggaga                                                    19


<210>  113
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<400>  113
gngnngcccn gcngncnag                                                    19


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  114
cnggagnacc ngncaccgng                                                   20


<210>  115
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is t or u

<400>  115
cnggagnacc ngncaccgng gngnc                                             25


<210>  116
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is t or u

<400>  116
gccnncngga gnaccngnca ccgng                                             25


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is t or u

<400>  117
gnaccngnca ccgnggngnc                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA intron 1 targeting sequence


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<400>  118
gccnncngga gnaccngnca                                                   20


<210>  119
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA targeting sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is t or u

<400>  119
ggcccnggnc ngcnggcncc cngcn                                             25


<210>  120
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligomer - GAA targeting sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is t or u

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n is t or u

<400>  120
gcncccngca gccccngcnn ngcag                                             25


<210>  121
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  121
cgttgttcag cgaggga                                                      17


<210>  122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  122
ctcctctgaa atgggctaca c                                                 21


<210>  123
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  123
acctcgtagc gcctgtta                                                     18


