                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
       Lee, Seok-Yong
       Ji, Ru-Rong
 
<120>  NAV1.7 ANTIBODIES AND METHODS OF USING THE SAME

<130>  028193-9166-WO00

<150>  US 61/874,234
<151>  2013-09-05

<150>  US 61/915,304
<151>  2013-12-12

<150>  US 61/944,388
<151>  2014-02-25

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

His His His His His His 
1               5       


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asp Asp Asp Asp Lys 
1               5   


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ala Asp Asp Asp Asp Lys 
1               5       


<210>  4
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Asp Gly Asn Tyr Arg Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140 


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Gly Phe Thr Phe Ser Ser Ser Tyr Ile Ser 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Gln Asp Gly Asn Tyr Arg Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Thr Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys 
1               5                   10                  15      


Val Ser Asp Ser Arg Ala Glu Thr Thr Val Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ser Met Ala Ile Gly Glu Lys Val Thr Ile Arg Cys Ile Thr Ser 
        35                  40                  45              


Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr 
                85                  90                  95      


Ile Glu Asn Met Leu Ser Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Ser Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys 
    


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Glu Gly Asn Thr Leu Arg Pro 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  12
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag       60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaagactt ctggcttcac cttcagcagt agctatataa gttggttgaa gcaaaagcct      180

ggacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtggtac tagctataat      240

cagaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg      300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag acaagatggt      360

aactacaggt actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
ggcttcacct tcagcagtag ctatataagt                                        30


<210>  14
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
tggatttatg ctggaactgg tggtactagc tataatcaga agttcacagg c                51


<210>  15
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
caagatggta actacaggta ctggtacttc gatgtc                                 36


<210>  16
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
atgaccatgt tctcactagc tcttctcctc agtcttcttc tcctctgtgt ctctgattct       60

agggcagaaa caactgtgac ccagtctcca gcatccctgt ccatggctat aggagaaaaa      120

gtcaccatca gatgcataac cagcactgat attgatgatg atatgaactg gtaccagcag      180

aagccagggg aacctcctaa gctccttatt tcagaaggca atactcttcg tcctggagtc      240

ccatcccgat tctccagcag tggctatggt acagattttg tttttacaat tgaaaacatg      300

ctctcagaag atgttgcaga ttactactgt ttgcaaagtg ataacttgcc tctcacgttc      360

ggagggggga ccaagctgga aataaaa                                          387


<210>  17
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
ataaccagca ctgatattga tgatgatatg aac                                    33


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gaaggcaata ctcttcgtcc t                                                 21


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
ttgcaaagtg ataacttgcc tctcacg                                           27


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

His His Pro Met Thr Glu Glu Phe Lys Asn 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Val Glu Leu Phe Leu Ala Asp Val Glu Gly 
1               5                   10  


<210>  22
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210>  23
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
1               5                   10                  15      


Val Leu Arg Ser Phe Arg Leu Leu 
            20                  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Leu Ser Leu Val Glu Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Leu Ser Leu Met Glu Leu Gly Leu Ser Arg Met Ser Asn Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Leu Ser Leu Met Glu Leu Ser Leu Ala Asp Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Leu Ser Phe Ala Asp Val Met Asn Cys Val Leu Gln Lys Arg Ser Trp 
1               5                   10                  15      


Pro Phe Leu Arg 
            20  


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ala Met Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala 
1               5                   10                  15      


Ile Gly Asn 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Ala Met Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val Leu Ser 
1               5                   10                  15      


Val Gly Asn 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ala Met Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val Leu Ser 
1               5                   10                  15      


Val Gly Asn 
            


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Ala Met Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val Leu Thr 
1               5                   10                  15      


Val Gly Asn 
            


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn Val Leu Thr 
1               5                   10                  15      


Val Gly Asn 
            


<210>  38
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln 
1               5                   10                  15      


Val Gly Asn 
            


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val Leu Ala 
1               5                   10                  15      


Val Gly Asn 
            


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Ala Met Glu His His Gly Met Ser Pro Thr Phe Glu Ala Met Leu Gln 
1               5                   10                  15      


Ile Gly Asn 
            


<210>  41
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met Leu Asn 
1               5                   10                  15      


Ile Gly Asn 
            


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Leu Ser Leu Val Glu Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Leu Ser Leu Met Glu Leu Gly Leu Ser Arg Met Gly Asn Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Leu Ser Leu Met Glu Leu Gly Leu Ala Asp Val Glu Gly Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  49
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Val Ser Leu Leu Glu Leu Ser Ala Ser Lys Lys Gly Ser Leu Ser Val 
1               5                   10                  15      


Leu Arg 
        


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Ser Ile Val Gly Met Phe Leu Ala Asp Leu Ile Glu Thr Tyr Phe Val 
1               5                   10                  15      


Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
            20                  25                  30  


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Phe Leu Ala Asp Leu Ile Glu Thr Tyr Phe 
1               5                   10      


