               SEQUENCE LISTING

<110> BioNovion

<120> METHOD FOR OBTAINING APRIL-BINDING PEPTIDES, PROCESS FOR PRODUCING THE PEPTIDES, APRIL-BINDING PEPTIDES OBTAINABLE WITH SAID METHOD/PROCESS AND USE OF THE APRIL-BINDING PEPTIDES 

<160> 50

<170> BiSSAP 1.2

<210> 1
<211> 345
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..345
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 1
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggagtg atatggggtg atggaagcac agagtataat     180

tcagctctca aatccagact gagcatcagc aaggacaagt ccaagagcca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agatgatgat     300

gttatggact actggggtca aggaacctca gtcaccgtct cctca                     345


<210> 2
<211> 323
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..323
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 2
agtattgtga tgacccagac tcccaaattc ctgcttgttt cagcaggaga cagggttacc      60

ataacctgca aggccggtca gagtgtgact aatgatgtag cttggtacca acagaagcca     120

gggcagtctc ctaaattgct gatatactat gcatccaatc gcttcactgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttcg ccatcagcac tgtgcaggct     240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga     300

ggcaccaagc tggaaatcaa acg                                             323


<210> 3
<211> 115
<212> PRT
<213> Mus musculus


<400> 3
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Gly Asp Gly Ser Thr Glu Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Lys Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 4
<211> 107
<212> PRT
<213> Mus musculus


<400> 4
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Gln Ser Val Thr Asn Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Ala Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 5
<211> 5
<212> PRT
<213> Mus musculus


<400> 5
Gly Tyr Gly Val Asn 
1               5   

<210> 6
<211> 16
<212> PRT
<213> Mus musculus


<400> 6
Val Ile Trp Gly Asp Gly Ser Thr Glu Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 7
<211> 7
<212> PRT
<213> Mus musculus


<400> 7
Asp Asp Asp Val Met Asp Tyr 
1               5           

<210> 8
<211> 11
<212> PRT
<213> Mus musculus


<400> 8
Lys Ala Gly Gln Ser Val Thr Asn Asp Val Ala 
1               5                   10      

<210> 9
<211> 7
<212> PRT
<213> Mus musculus


<400> 9
Tyr Ala Ser Asn Arg Phe Thr 
1               5           

<210> 10
<211> 9
<212> PRT
<213> Mus musculus


<400> 10
Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   

<210> 11
<211> 366
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 11
caggagcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacattgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggagtt atatgggctg gtggaagcac aaattataac     180

tcggctctca tgtccagact gagcatcagt agagacaact ccaagagcca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agaggggctt     300

gacacctcgg gcttctacta tgctatggac tactggggtc aaggaacctc agtcaccgtc     360

tcctca                                                                366


<210> 12
<211> 323
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..323
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 12
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      60

atcagttgca gggcaggtca ggccattagc aattatttaa actggtatca gcagaaacca     120

ggtggaactg ttaaactcct gatctactac acatcaaaat tacactcagg agtcccatca     180

aggttcagtg gcagtggctc tggaacagat tattctctca ccattagcaa cctggaacaa     240

gaagatattg ccacttactt ttgccaacag ggttatacgc ttccgtacac gttcggaggg     300

gggaccaagc tggaaataaa acg                                             323


<210> 13
<211> 122
<212> PRT
<213> Mus musculus


<400> 13
Gln Glu Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Gly Leu Asp Thr Ser Gly Phe Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         

<210> 14
<211> 107
<212> PRT
<213> Mus musculus


<400> 14
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Gly Gln Ala Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 15
<211> 5
<212> PRT
<213> Mus musculus


<400> 15
Ser Tyr Gly Val His 
1               5   

<210> 16
<211> 16
<212> PRT
<213> Mus musculus


<400> 16
Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      



<210> 17
<211> 14
<212> PRT
<213> Mus musculus


<400> 17
Glu Gly Leu Asp Thr Ser Gly Phe Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  

<210> 18
<211> 11
<212> PRT
<213> Mus musculus


<400> 18
Arg Ala Gly Gln Ala Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 19
<211> 7
<212> PRT
<213> Mus musculus


<400> 19
Tyr Thr Ser Lys Leu His Ser 
1               5           

<210> 20
<211> 9
<212> PRT
<213> Mus musculus


<400> 20
Gln Gln Gly Tyr Thr Leu Pro Tyr Thr 
1               5                   

<210> 21
<211> 345
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..345
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 21
caggtgcagt tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggagtg atatggggtg atggaagcac agagtataat     180

tcagctctca aatccagact gagcatcagc aaggacaagt ccaagagcca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agatgatgat     300

gttatggact actggggtca aggaacctca gtcaccgtct cctca                     345


<210> 22
<211> 323
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..323
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 22
agtattgtga tgacccagac tcccaaattc ctgcttgttt cagcaggaga cagcattacc      60

ataacctgca aggccgatca gagtgtgagt agtgatgtag cttggtacca acagaaggca     120

gggcagtctc ctaaattgct gatatactat gcatccaatc gctacactgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttcg ccatcagctc tgtgcaggct     240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga     300

ggcaccaagc tggaaatcaa acg                                             323


<210> 23
<211> 115
<212> PRT
<213> Mus musculus


<400> 23
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Gly Asp Gly Ser Thr Glu Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Lys Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Asp Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 24
<211> 107
<212> PRT
<213> Mus musculus


<400> 24
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Ser Ile Thr Ile Thr Cys Lys Ala Asp Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Ala Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 25
<211> 5
<212> PRT
<213> Mus musculus


<400> 25
Gly Tyr Gly Val Asn 
1               5   

<210> 26
<211> 16
<212> PRT
<213> Mus musculus


<400> 26
Val Ile Trp Gly Asp Gly Ser Thr Glu Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 27
<211> 7
<212> PRT
<213> Mus musculus


<400> 27
Asp Asp Asp Val Met Asp Tyr 
1               5           

<210> 28
<211> 11
<212> PRT
<213> Mus musculus


<400> 28
Lys Ala Asp Gln Ser Val Ser Ser Asp Val Ala 
1               5                   10      

<210> 29
<211> 7
<212> PRT
<213> Mus musculus


<400> 29
Tyr Ala Ser Asn Arg Tyr Thr 
1               5           

<210> 30
<211> 9
<212> PRT
<213> Mus musculus


<400> 30
Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   

<210> 31
<211> 354
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 31
caggtgcagc tgaaggagtc aggacctggc ctggtagcac cctcacagag cctgtccatc      60

acatgcactg tctctgggtt ctcattatcc agatatagtg tacactgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggaatg atatggggtg gtggaagcac agactataat     180

tcagctctca aatccagact gagcatcagc aaggacaact ccaagaggca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccag atctaactgg     300

gagatctatg ctttggacta ttggggtcaa ggaacctcag tcaccgtctc ctca           354


<210> 32
<211> 335
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..335
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 32
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca aggccagcca aagtattgat tatgatggtg ataattatat gaactggtac     120

caacagaaac caggacagcc acccaaactc ctcatctatg ttgcatccag tctagaatct     180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatgt ggagccgtac     300

acgttcggag gggggaccaa gctggaaata aaacg                                335


<210> 33
<211> 118
<212> PRT
<213> Mus musculus


<400> 33
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          
Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Arg Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Asn Trp Glu Ile Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 34
<211> 111
<212> PRT
<213> Mus musculus


<400> 34
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Ile Asp Tyr Asp 
            20                  25                  30          
Gly Asp Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Ser Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      
Val Glu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 35
<211> 5
<212> PRT
<213> Mus musculus


<400> 35
Arg Tyr Ser Val His 
1               5   

<210> 36
<211> 16
<212> PRT
<213> Mus musculus


<400> 36
Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 37
<211> 10
<212> PRT
<213> Mus musculus


<400> 37
Ser Asn Trp Glu Ile Tyr Ala Leu Asp Tyr 
1               5                   10  

<210> 38
<211> 15
<212> PRT
<213> Mus musculus


<400> 38
Lys Ala Ser Gln Ser Ile Asp Tyr Asp Gly Asp Asn Tyr Met Asn 
1               5                   10                  15  

<210> 39
<211> 7
<212> PRT
<213> Mus musculus


<400> 39
Val Ala Ser Ser Leu Glu Ser 
1               5           

<210> 40
<211> 9
<212> PRT
<213> Mus musculus


<400> 40
Gln Gln Ser Asn Val Glu Pro Tyr Thr 
1               5                   

<210> 41
<211> 354
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 41
caggtgcagc tgaaggagtc aggacctggc ctggtggcac cctcacagag cctgtccatc      60

acatgcactg tctctgggtt ctcattatcc agatatagta tacactgggt tcgccagcct     120

ccaagaaagg gtctggagtg gctgggaatg atatggggtg gtggaagcac agactataat     180

tcagctctca aatccagact gagcatcaac aaggacaact ccaagaggca agttttctta     240

aaaatgcaca gtctgcaaac tgatgacaca gccatctact actgtgccag atctaactgg     300

gagatctatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca           354


<210> 42
<211> 335
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..335
<223> /mol_type="unassigned DNA"
      /organism="Mus musculus"

<400> 42
gacattgtgc tgacccaatc tccaccttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca aggccagcca aagtattgat tatgatggtg atcgttatat gaactggtac     120

caacagaaac caggacagcc acccaaactc ctcatctatg ttgcatccaa tctagaatct     180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtcatga ggagccgcac     300

acgttcggag gggggaccaa gctggaaata aaacg                                335


<210> 43
<211> 118
<212> PRT
<213> Mus musculus


<400> 43
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Arg Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met His Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Asn Trp Glu Ile Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 44
<211> 111
<212> PRT
<213> Mus musculus


<400> 44
Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Ile Asp Tyr Asp 
            20                  25                  30          
Gly Asp Arg Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      
Glu Glu Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 45
<211> 5
<212> PRT
<213> Mus musculus


<400> 45
Arg Tyr Ser Ile His 
1               5   

<210> 46
<211> 16
<212> PRT
<213> Mus musculus


<400> 46
Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 47
<211> 10
<212> PRT
<213> Mus musculus


<400> 47
Ser Asn Trp Glu Ile Tyr Ala Met Asp Tyr 
1               5                   10  

<210> 48
<211> 15
<212> PRT
<213> Mus musculus


<400> 48
Lys Ala Ser Gln Ser Ile Asp Tyr Asp Gly Asp Arg Tyr Met Asn 
1               5                   10                  15  

<210> 49
<211> 7
<212> PRT
<213> Mus musculus


<400> 49
Val Ala Ser Asn Leu Glu Ser 
1               5           

<210> 50
<211> 9
<212> PRT
<213> Mus musculus


<400> 50
Gln Gln Ser His Glu Glu Pro His Thr 
1               5                   

