                         SEQUENCE LISTING

<110>  Queen Mary University of London
 
<120>  MOLECULE

<130>  P103008PCT

<150>  GB1315788.8
<151>  2013-09-05

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  1

Ser Tyr Ala Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  2

Ala Ile Tyr Thr Ser Gly Asn Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  3

Asn Ala Ser Asn Phe Asp Tyr 
1               5           


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  4

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  5

Ser Ala Ser Asn Leu Gln Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  6

Gln Gln Gly Ser Asp Ala Pro Ala Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  7

Asp Tyr Ala Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  8

Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Thr Ser Gly Asn Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Ala Ser Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Asp Ala Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sincle-chain variable fragment (scFv)

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Thr Ser Gly Asn Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Ala Ser Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser 
    210                 215                 220                 


Asp Ala Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235                 240 


Ala Ala Ala 
            


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  12

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10          


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  13

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  14

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  15

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serine-glycine linker

<400>  18

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A peptide sequence derived from Foot and Mouth Disease Virus

<400>  19

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  20
<211>  3278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence for bispecific antibody A7/Adalimumab

<400>  20
atgggctgga gcctgatcct cctgttcctc gtcgctgtgg ctacaggtaa ggggctcaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggt ggcgcgcatg ccgaagtgca gctggtggaa tctggcggcg gactggtgca      180

gcctggcaga tccctgagac tgtcttgtgc cgcctccggc ttcaccttcg acgactacgc      240

tatgcactgg gtgcgacagg cccctggcaa gggactggaa tgggtgtccg ccatcacctg      300

gaactccggc cacatcgact acgccgactc tgtggaaggc cggttcacca tctctcggga      360

caacgccaag aactccctgt acctgcagat gaacagcctg cgggccgagg acaccgccgt      420

gtactactgt gccaaggtgt cctacctgtc caccgcctcc tccctggatt attggggcca      480

gggcaccctc gtgaccgtgt ctagcggagg cggaggatca ggcggtggtg gttcaggtgg      540

cggaggctct accgacatcc agatgaccca gtccccctcc agcctgtctg cctctgtggg      600

cgacagagtg accatcacat gccgggcctc ccagggcatc agaaactacc tggcctggta      660

tcagcagaag cccggcaagg cccccaagct gctgatctac gctgcctcca cactgcagtc      720

cggcgtgccc tccagattct ccggctctgg ctctggcacc gactttaccc tgaccatcag      780

ctccctgcag cccgaggatg tggccaccta ctactgccag cggtacaaca gagcccccta      840

caccttcgga cagggcacca aggtggaaat caaggctagc gacaagaccc acacctgtcc      900

cccttgccct gcccctgagc tgctgggcgg accctccgtg ttcctgttcc ccccaaagcc      960

caaggacacc ctgatgatct cccggacccc cgaagtgacc tgcgtggtgg tggacgtgtc     1020

ccacgaggac cctgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaacgc     1080

caagaccaag cccagagagg aacagtacaa cagcacctac cgggtggtgt ccgtgctgac     1140

cgtgctgcac caggactggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggc     1200

cctgcctgcc cccatcgaaa agaccatctc caaggccaag ggccagcccc gcgagcctca     1260

ggtgtacaca ctgcccccca gccgggaaga gatgaccaag aaccaggtgt ccctgacctg     1320

cctggtcaag ggcttctacc cctccgatat cgccgtggaa tgggagtcca acggacagcc     1380

cgaaaacaac tacaagacca ccccccctgt gctggactcc gacggctcat tcttcctgac     1440

ctccaagctg accgtggaca agtcccggtg gcagcagggc aacgtgttct cctgctccgt     1500

gatgcacgag gccctgcaca accactacac ccagaagtcc ctgtccctga gccccggcaa     1560

gacctccggc aagcccatcc ctaaccccct gctgggcctg gactccacca gagccaagag     1620

ggcaccggtg aagcagaccc tgaacttcga cctgctgaag ctggccggcg acgtggaatc     1680

caaccctggc cctatgggct ggagcctgat cctcctgttc ctcgtcgctg tggctacagg     1740

taaggggctc acagtagcag gcttgaggtc tggacatata tatgggtgac aatgacatcc     1800

actttgcctt tctctccaca ggtggcgcgc atgccgaagt gcagctgctg gaatctggcg     1860

gcggactggt gcagcctggc ggatctctga gactgtcttg tgccgcctcc ggcttcacct     1920

tctccagcta cgccatgtcc tgggtgcgac aggctcctgg caagggcctg gaatgggtgt     1980

ccgccatcta cacctccggc aactccacct cctacgccga ctccgtgaag ggccggttca     2040

ccatctcccg ggacaactcc aagaacaccc tgtacctgca gatgaactcc ctgcgggccg     2100

aggacaccgc cgtgtactac tgtgccaaga acgcctccaa cttcgactac tggggccagg     2160

gcaccctcgt gacagtgtct agcggaggcg gaggatcagg tggcggtgga tctggcggag     2220

ggggctctac cgatatccag atgacccagt ccccctccag cctgtctgcc tctgtgggcg     2280

acagagtgac catcacctgt cgggcctccc agtccatctc ctcctacctg aactggtatc     2340

agcagaagcc cggcaaggcc cccaagctgc tgatctactc cgccagcaac ctgcagtccg     2400

gcgtgccctc cagattctcc ggctctggct ctggcaccga ctttaccctg accatcagct     2460

ccctgcagcc tgaggacttc gccacctact actgccagca gggctctgat gcccctgcca     2520

cctttggaca gggcaccaag gtggaaatca agcgggctgc cgctgctagc gataagacac     2580

atacctgccc cccctgtcca gctcccgaac tgctgggagg cccttctgtg tttctgtttc     2640

cacccaagcc taaagataca ctgatgatca gccgcacccc tgaagtcaca tgtgtggtgg     2700

tcgatgtgtc tcatgaagat cccgaagtca agtttaactg gtatgtggat ggggtcgagg     2760

tccacaatgc taagacaaag cctcgggaag aacagtataa ctccacatat cgcgtcgtgt     2820

ctgtcctgac agtcctgcat caggattggc tgaatgggaa agaatacaaa tgtaaagtct     2880

ctaacaaggc tctgcccgct cctatcgaga aaaccatcag caaggctaaa ggacagccca     2940

gagaacccca ggtctacacc ctgcctccat ctcgcgagga aatgacaaaa aatcaggtgt     3000

cactgtattg tctggtcaaa gggttttacc ccagcgacat tgccgtcgag tgggagagca     3060

atggccagcc tgaaaacaat tataagacaa cacctcccgt cctggacagc gacggatcat     3120

tttttctgta ctctaagctg acagtcgaca agagcagatg gcagcaggga aatgtcttta     3180

gctgcagcgt gatgcatgaa gctctgcata atcattatac ccagaagagt ctgagcctgt     3240

cccccggcaa gggcggctct caccaccatc atcaccac                             3278


<210>  21
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for bispecific antibody A7/Adalimumab, 
       Adalimumab chain

<400>  21

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Val 
1               5                   10                  15      


Ala Arg Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Ala Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Ser Gly Lys 
                485                 490                 495     


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
            500                 505             


<210>  22
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for bispecific antibody A7/Adalimumab, A7 
       chain

<400>  22

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Val 
1               5                   10                  15      


Ala Arg Met Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Tyr Thr Ser Gly Asn Ser Thr Ser Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asn Ala Ser Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Gly Ser Asp Ala Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                245                 250                 255     


Ile Lys Arg Ala Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
385                 390                 395                 400 


Glu Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser His His 
                485                 490                 495     


His His His His 
            500 


