                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       UNIVERSITE PARIS DIDEROT PARIS 7
 
<120>  PIN1 INHIBITORS FOR USE IN THE PREVENTION AND/OR TREATMENT OF 
       THEILERIOSIS, AND RELATED APPLICATIONS

<130>  366293D32471

<150>  EP13306234.9
<151>  2013-09-09

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN amino-acid sequence (without the signal peptide)

<400>  1

Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
1               5                   10                  15      


Asn Thr Gly Met Ala Val Thr Arg Thr Lys Glu Glu Ala Val Ser Glu 
            20                  25                  30          


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Asp Asn Leu Asp Gln 
        35                  40                  45              


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
    50                  55                  60                  


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
65                  70                  75                  80  


Phe Thr Glu Ala Ser Phe Lys Leu Glu Val Asn Glu Ile Ser Asp Leu 
                85                  90                  95      


Val Glu Thr Asp Ser Gly Val His Leu Ile Tyr Arg Ile Ala 
            100                 105                 110 


<210>  2
<211>  333
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN nucleotide sequence (without the signal peptide)

<400>  2
gcccacttgc tactaaagca cactggatct aggaatccag tgaataggaa tactggaatg       60

gcagtaacaa gaacgaaaga agaggctgta agtgagatga aaggttattt ggaaatgctg      120

aggaaatctg ataatctgga ccaagagttt aggagacttg caactgccaa atctgagtgt      180

tcaagcgcaa gaaaaggggg agatttaggc tttttcgata gaaacaccat gcaaaaaccc      240

tttacggaag cctcatttaa acttaaggtt aatgagatta gtgacctggt tgagactgat      300

tctggagtac atcttatata tagaatcgca taa                                   333


<210>  3
<211>  32
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN signal peptide amino-acid sequence

<400>  3

Met Ile Arg Asn Phe Leu Asn Phe Leu Trp Asn Asn Thr Ser Leu Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Phe Ala Met Asp Lys Val Arg Cys 
            20                  25                  30          


<210>  4
<211>  96
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN signal peptide nucleotide sequence

<400>  4
atgattcgga attttctaaa ttttttgtgg aataatacta gcttaagatt tttaataatt       60

aatacaatta tatttgcaat ggacaaggtt agatgt                                 96


<210>  5
<211>  32
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  T22I/A26L mutated TaPIN signal peptide amino-acid sequence

<400>  5

Met Ile Arg Asn Phe Leu Asn Phe Leu Trp Asn Asn Thr Ser Leu Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Ile Ile Ile Phe Leu Met Asp Lys Val Arg Cys 
            20                  25                  30          


<210>  6
<211>  96
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  T22I/A26L mutated TaPIN signal peptide nucleotide sequence

<400>  6
atgattcgga attttctaaa ttttttgtgg aataatacta gcttaagatt tttaataatt       60

aatataatta tatttctaat ggacaaggtg agatgt                                 96


<210>  7
<211>  142
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN amino-acid sequence (with the signal peptide)

<400>  7

Met Ile Arg Asn Phe Leu Asn Phe Leu Trp Asn Asn Thr Ser Leu Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Phe Ala Met Asp Lys Val Arg Cys 
            20                  25                  30          


Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
        35                  40                  45              


Asn Thr Gly Met Ala Val Thr Arg Thr Lys Glu Glu Ala Val Ser Glu 
    50                  55                  60                  


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Asp Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
                85                  90                  95      


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
            100                 105                 110         


Phe Thr Glu Ala Ser Phe Lys Leu Glu Val Asn Glu Ile Ser Asp Leu 
        115                 120                 125             


Val Glu Thr Asp Ser Gly Val His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140         


<210>  8
<211>  429
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  wt TaPIN nucleotide sequence (with the signal peptide)

<400>  8
atgattcgga attttctaaa ttttttgtgg aataatacta gcttaagatt tttaataatt       60

aatacaatta tatttgcaat ggacaaggtt agatgtgccc acttgctact aaagcacact      120

ggatctagga atccagtgaa taggaatact ggaatggcag taacaagaac gaaagaagag      180

gctgtaagtg agatgaaagg ttatttggaa atgctgagga aatctgataa tctggaccaa      240

gaatttagga gacttgcaac tgccaaatct gagtgttcaa gcgcaagaaa agggggagat      300

ttaggctttt tcgatagaaa caccatgcaa aaacccttta cggaagcctc atttaaactt      360

gaggttaatg agattagtga cctggttgaa actgactctg gagtacatct tatatataga      420

atcgcataa                                                              429


<210>  9
<211>  110
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  A53P mutated TaPIN amino-acid sequence (without the signal 
       peptide)

<400>  9

Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
1               5                   10                  15      


Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Ser Glu 
            20                  25                  30          


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Asp Asn Leu Asp Gln 
        35                  40                  45              


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
    50                  55                  60                  


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
65                  70                  75                  80  


Phe Thr Glu Ala Ser Phe Lys Leu Glu Val Asn Glu Ile Ser Asp Leu 
                85                  90                  95      


Val Glu Thr Asp Ser Gly Val His Leu Ile Tyr Arg Ile Ala 
            100                 105                 110 


<210>  10
<211>  333
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  A53P mutated TaPIN nucleotide sequence (without the signal 
       peptide)

<400>  10
gcccatttgc tactaaagca cactggatct aggaatccag tgaacaggaa tactggaatg       60

ccagtaacaa gaacgaaaga agaggctgta agtgagatga aaggttattt ggaaatgctg      120

aggaaatctg ataatctgga ccaagagttt aggagacttg caactgccaa atctgagtgt      180

tcaagcgcaa gaaaaggagg agatttaggc tttttcgata gaaacaccat gcaaaaaccc      240

tttacggaag cctcatttaa acttaaggtt aatgagatta gtgacctggt tgagactgat      300

tctggagtac atcttatata tagaatcgca taa                                   333


<210>  11
<211>  142
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  A53P mutated TaPIN amino-acid sequence (with the signal peptide)

<400>  11

Met Ile Arg Asn Phe Leu Asn Phe Leu Trp Asn Asn Thr Ser Leu Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Phe Ala Met Asp Lys Val Arg Cys 
            20                  25                  30          


Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
        35                  40                  45              


Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Ser Glu 
    50                  55                  60                  


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Asp Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
                85                  90                  95      


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
            100                 105                 110         


Phe Thr Glu Ala Ser Phe Lys Leu Glu Val Asn Glu Ile Ser Asp Leu 
        115                 120                 125             


Val Glu Thr Asp Ser Gly Val His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140         


<210>  12
<211>  429
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  A53P mutated TaPIN nucleotide sequence (with the  signal peptide)

<400>  12
atgattcgga attttctaaa ttttttgtgg aataatacta gcttaagatt tttaataatt       60

aatacaatta tatttgcaat ggacaaggtg agatgtgccc atttgctact aaagcacact      120

ggatctagga atccagtgaa caggaatact ggaatgccag taacaagaac gaaagaagag      180

gctgtaagtg agatgaaagg ttatttggaa atgctgagga aatctgataa tctggaccaa      240

gagtttagga gacttgcaac tgccaaatct gagtgttcaa gcgcaagaaa aggaggagat      300

ttaggctttt tcgatagaaa caccatgcaa aaacccttta cggaagcctc atttaaactt      360

aaggttaatg agattagtga cctggttgag actgattctg gagtacatct tatatataga      420

atcgcataa                                                              429


<210>  13
<211>  142
<212>  PRT
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  T22I/A26L/A53P mutated TaPIN amino-acid sequence (with the signal
       peptide)

<400>  13

Met Ile Arg Asn Phe Leu Asn Phe Leu Trp Asn Asn Thr Ser Leu Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Ile Ile Ile Phe Leu Met Asp Lys Val Arg Cys 
            20                  25                  30          


Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
        35                  40                  45              


Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Ser Glu 
    50                  55                  60                  


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Asp Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
                85                  90                  95      


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
            100                 105                 110         


Phe Thr Glu Ala Ser Phe Lys Leu Glu Val Asn Glu Ile Ser Asp Leu 
        115                 120                 125             


Val Glu Thr Asp Ser Gly Val His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140         


<210>  14
<211>  429
<212>  DNA
<213>  Theileria annulata


<220>
<221>  misc_feature
<223>  T22I/A26L/A53P mutated TaPIN nucleotide sequence (with the signal
       peptide)

<400>  14
atgattcgga attttctaaa ttttttgtgg aataatacta gcttaagatt tttaataatt       60

aatataatta tatttctaat ggacaaggtg agatgtgccc atttgctact aaagcacact      120

ggatctagga atccagtgaa caggaatact ggaatgccag taacaagaac gaaagaagag      180

gctgtaagtg agatgaaagg ttatttggaa atgctgagga aatctgataa tctggaccaa      240

gagtttagga gacttgcaac tgccaaatct gagtgttcaa gcgcaagaaa aggaggagat      300

ttaggctttt tcgatagaaa caccatgcaa aaacccttta cggaagcctc atttaaactt      360

aaggttaatg agattagtga cctggttgag actgattctg gagtacatct tatatataga      420

atcgcataa                                                              429


<210>  15
<211>  110
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN amino-acid sequence (without the signal peptide)

<400>  15

Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
1               5                   10                  15      


Asn Thr Gly Met Ala Val Thr Arg Thr Lys Glu Glu Ala Val Asn Glu 
            20                  25                  30          


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Glu Asn Leu Asp Gln 
        35                  40                  45              


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
    50                  55                  60                  


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
65                  70                  75                  80  


Phe Thr Glu Ala Ser Phe Asn Leu Lys Val Asn Glu Ile Ser Asp Leu 
                85                  90                  95      


Val Glu Thr Asp Ser Gly Ile His Leu Ile Tyr Arg Ile Ala 
            100                 105                 110 


<210>  16
<211>  333
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN nucleotide sequence (without the signal peptide)

<400>  16
gctcacctgt tactaaagca cactggatct aggaatccag tgaatagaaa cactggaatg       60

gccgtaacga gaacaaaaga agaagcggtg aatgaaatga aaggttattt ggaaatgctg      120

aggaaatctg aaaacctgga tcaagaattc aggagacttg caacggctaa atccgagtgt      180

tcaagtgcaa ggaaaggagg tgatttaggc ttctttgatc gaaacacaat gcaaaaacct      240

tttactgaag cttcatttaa cctcaaggtt aatgagatta gtgacctggt tgaaactgat      300

tccgggatac atcttatata cagaatcgca taa                                   333


<210>  17
<211>  33
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN signal peptide amino acid sequence

<400>  17

Met Ile Arg Cys Phe Leu Asn Phe Leu Trp Asn Lys Thr Ser Phe Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Lys Phe Thr Met Asp Lys Val Arg 
            20                  25                  30          


Cys 
    


<210>  18
<211>  99
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN signal peptide nucleotide sequence

<400>  18
atgattcgtt gctttctaaa ttttttgtgg aataaaacta gttttagatt tctaataatt       60

aatacaataa tcaagtttac catggataag gtgcgatgt                              99


<210>  19
<211>  33
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  T22I/T27L mutated TpPIN signal peptide amino-acid sequence

<400>  19

Met Ile Arg Cys Phe Leu Asn Phe Leu Trp Asn Lys Thr Ser Phe Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Ile Ile Ile Lys Phe Leu Met Asp Lys Val Arg 
            20                  25                  30          


Cys 
    


<210>  20
<211>  99
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  T22I/T27L mutated TpPIN signal peptide nucleotide sequence

<400>  20
atgattcgtt gctttctaaa ttttttgtgg aataaaacta gttttagatt tctaataatt       60

aatataataa tcaagtttct catggataag gtgcgatgt                              99


<210>  21
<211>  143
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN amino-acid sequence (with the signal peptide)

<400>  21

Met Ile Arg Cys Phe Leu Asn Phe Leu Trp Asn Lys Thr Ser Phe Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Lys Phe Thr Met Asp Lys Val Arg 
            20                  25                  30          


Cys Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn 
        35                  40                  45              


Arg Asn Thr Gly Met Ala Val Thr Arg Thr Lys Glu Glu Ala Val Asn 
    50                  55                  60                  


Glu Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Glu Asn Leu Asp 
65                  70                  75                  80  


Gln Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala 
                85                  90                  95      


Arg Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys 
            100                 105                 110         


Pro Phe Thr Glu Ala Ser Phe Asn Leu Lys Val Asn Glu Ile Ser Asp 
        115                 120                 125             


Leu Val Glu Thr Asp Ser Gly Ile His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140             


<210>  22
<211>  432
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  wt TpPIN nucleotide sequence (with the signal peptide)

<400>  22
atgattcgtt gctttctaaa ttttttgtgg aataaaacta gttttagatt tctaataatt       60

aatacaataa tcaagtttac catggataag gtgcgatgtg ctcacctgtt actaaagcac      120

actggatcta ggaatccagt gaatagaaac actggaatgg ccgtaacgag aacaaaagaa      180

gaagcggtga atgaaatgaa aggttatttg gaaatgctga ggaaatctga aaacctggat      240

caagaattca ggagacttgc aacggctaaa tccgagtgtt caagtgcaag gaaaggaggt      300

gatttaggct tctttgatcg aaacacaatg caaaaacctt ttactgaagc ttcatttaac      360

ctcaaggtta atgagattag tgacctggtt gaaactgatt ccgggataca tcttatatac      420

agaatcgcat aa                                                          432


<210>  23
<211>  110
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  A54P mutated TpPIN amino-acid sequence (without the signal 
       peptide)

<400>  23

Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn Arg 
1               5                   10                  15      


Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Asn Glu 
            20                  25                  30          


Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Glu Asn Leu Asp Gln 
        35                  40                  45              


Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala Arg 
    50                  55                  60                  


Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys Pro 
65                  70                  75                  80  


Phe Thr Glu Ala Ser Phe Asn Leu Lys Val Asn Glu Ile Ser Asp Leu 
                85                  90                  95      


Val Glu Thr Asp Ser Gly Ile His Leu Ile Tyr Arg Ile Ala 
            100                 105                 110 


<210>  24
<211>  333
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  A54P mutated TpPIN nucleotide sequence (without the signal 
       peptide)

<400>  24
gctcacctgt tactaaagca cactggatct aggaatccag tgaatagaaa cactggaatg       60

cccgtaacga gaacaaaaga agaagcggtg aatgaaatga aaggttattt ggaaatgctg      120

aggaaatctg aaaacctgga tcaagaattc aggagacttg caacggctaa atccgagtgt      180

tcaagtgcaa ggaaaggagg tgatttaggc ttctttgatc gaaacacaat gcaaaaacct      240

tttactgaag cttcatttaa cctcaaggtt aatgagatta gtgacctggt tgaaactgat      300

tccgggatac atcttatata cagaatcgca taa                                   333


<210>  25
<211>  143
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  A54P mutated TpPIN amino-acid sequence (with the signal peptide)

<400>  25

Met Ile Arg Cys Phe Leu Asn Phe Leu Trp Asn Lys Thr Ser Phe Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Thr Ile Ile Lys Phe Thr Met Asp Lys Val Arg 
            20                  25                  30          


Cys Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn 
        35                  40                  45              


Arg Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Asn 
    50                  55                  60                  


Glu Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Glu Asn Leu Asp 
65                  70                  75                  80  


Gln Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala 
                85                  90                  95      


Arg Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys 
            100                 105                 110         


Pro Phe Thr Glu Ala Ser Phe Asn Leu Lys Val Asn Glu Ile Ser Asp 
        115                 120                 125             


Leu Val Glu Thr Asp Ser Gly Ile His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140             


<210>  26
<211>  432
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  A54P mutated TpPIN nucleotide sequence (with the signal peptide)

<400>  26
atgattcgtt gctttctaaa ttttttgtgg aataaaacta gttttagatt tctaataatt       60

aatacaataa tcaagtttac catggataag gtgcgatgtg ctcacctgtt actaaagcac      120

actggatcta ggaatccagt gaatagaaac actggaatgc ccgtaacgag aacaaaagaa      180

gaagcggtga atgaaatgaa aggttatttg gaaatgctga ggaaatctga aaacctggat      240

caagaattca ggagacttgc aacggctaaa tccgagtgtt caagtgcaag gaaaggaggt      300

gatttaggct tctttgatcg aaacacaatg caaaaacctt ttactgaagc ttcatttaac      360

ctcaaggtta atgagattag tgacctggtt gaaactgatt ccgggataca tcttatatac      420

agaatcgcat aa                                                          432


<210>  27
<211>  143
<212>  PRT
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  T22I/A27L/A54P mutated TpPIN amino-acid sequence (with the signal
       peptide)

<400>  27

Met Ile Arg Cys Phe Leu Asn Phe Leu Trp Asn Lys Thr Ser Phe Arg 
1               5                   10                  15      


Phe Leu Ile Ile Asn Ile Ile Ile Lys Phe Leu Met Asp Lys Val Arg 
            20                  25                  30          


Cys Ala His Leu Leu Leu Lys His Thr Gly Ser Arg Asn Pro Val Asn 
        35                  40                  45              


Arg Asn Thr Gly Met Pro Val Thr Arg Thr Lys Glu Glu Ala Val Asn 
    50                  55                  60                  


Glu Met Lys Gly Tyr Leu Glu Met Leu Arg Lys Ser Glu Asn Leu Asp 
65                  70                  75                  80  


Gln Glu Phe Arg Arg Leu Ala Thr Ala Lys Ser Glu Cys Ser Ser Ala 
                85                  90                  95      


Arg Lys Gly Gly Asp Leu Gly Phe Phe Asp Arg Asn Thr Met Gln Lys 
            100                 105                 110         


Pro Phe Thr Glu Ala Ser Phe Asn Leu Lys Val Asn Glu Ile Ser Asp 
        115                 120                 125             


Leu Val Glu Thr Asp Ser Gly Ile His Leu Ile Tyr Arg Ile Ala 
    130                 135                 140             


<210>  28
<211>  432
<212>  DNA
<213>  Theileria parva


<220>
<221>  misc_feature
<223>  T22I/A27L/A54P mutated TpPIN nucleotide sequence (with the signal
       peptide)

<400>  28
atgattcgtt gctttctaaa ttttttgtgg aataaaacta gttttagatt tctaataatt       60

aatataataa tcaagtttct catggataag gtgcgatgtg ctcacctgtt actaaagcac      120

actggatcta ggaatccagt gaatagaaac actggaatgc ccgtaacgag aacaaaagaa      180

gaagcggtga atgaaatgaa aggttatttg gaaatgctga ggaaatctga aaacctggat      240

caagaattca ggagacttgc aacggctaaa tccgagtgtt caagtgcaag gaaaggaggt      300

gatttaggct tctttgatcg aaacacaatg caaaaacctt ttactgaagc ttcatttaac      360

ctcaaggtta atgagattag tgacctggtt gaaactgatt ccgggataca tcttatatac      420

agaatcgcat aa                                                          432


<210>  29
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  TaCycophilin F primer

<400>  29
ccgctcgagt tctacaatca acccaagcat                                        30


<210>  30
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  TaCycophilin R primer

<400>  30
aaggaaaaaa gcggccgctc acaataattc tccacagtcc                             40


<210>  31
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  human PIN1 F primer

<400>  31
ccgctcgagg cggacgagga gaagctg                                           27


<210>  32
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  human PIN1 R primer

<400>  32
aaggaaaaaa gcggccgctc actcagtgcg gaggatga                               38


<210>  33
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  wt TaPIN F primer

<400>  33
ccgctcgagg cccacttgct actaaag                                           27


<210>  34
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  wt TaPIN R primer

<400>  34
ataagaatgc ggccgcttat gcgattctat atataagatg                             40


<210>  35
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  TaPIN sequencing primer

<400>  35
ccgctcgagg cccacttgct actaaag                                           27


<210>  36
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  TaPIN sequencing primer

<400>  36
ataagaatgc ggccgcttat gcgattctat atataagatg                             40


<210>  37
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  TaPIN sequencing primer

<400>  37
gtctgtcaaa taggtagaaa tc                                                22


<210>  38
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  TaPIN sequencing primer

<400>  38
gagaggaagt tgaatcaaac at                                                22


<210>  39
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  K38ATaPIN F primer

<400>  39
gcccacttgc tactagcgca cactggatct agg                                    33


<210>  40
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  K38ATaPIN R primer

<400>  40
cctagatcca gtgtgcgtag tagcaagtgg gc                                     32


<210>  41
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  A53PTaPIN F primer

<400>  41
ggaatactgg aatgccagta acaagaac                                          28


<210>  42
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  A53PTaPIN R primer

<400>  42
gttcttgtta ctggcattcc agtattcc                                          28


<210>  43
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  43 C92ATaPIN F primer

<400>  43
gcaactgcca aatctgaggc ttcaagcgca agaaaagg                               38


<210>  44
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  43 C92ATaPIN R primer

<400>  44
ccttttcttg cgcttgaagc ctcagatttg gcagttgc                               38


<210>  45
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  HKII F primer

<400>  45
cgaccaagtg cagaaggttg                                                   20


<210>  46
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  HKII R primer

<400>  46
cgtctggagt agacctcac                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  GLUT1 F primer

<400>  47
catggagccc accagcaag                                                    19


<210>  48
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  GLUT1 R primer

<400>  48
cgttgatgac tccagtgttg                                                   20


<210>  49
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LDHA F primer

<400>  49
ggctacacat cctgggcc                                                     18


<210>  50
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  LDHA R primer

<400>  50
ggaacactaa ggaagacatc c                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PDK1 F primer

<400>  51
ctaggcgtct gtgtgatttg                                                   20


<210>  52
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  PDK1 R primer

<400>  52
gatagaggtg ggatggtac                                                    19


<210>  53
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  HIF1a F primer

<400>  53
catgtgacca cgaggaaatg                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  HIF1a R primer

<400>  54
tagttctccc ccggctagtt                                                   20


<210>  55
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  PKM2 F primer

<400>  55
ccattaccag cgaccccac                                                    19


<210>  56
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PKM2 R primer

<400>  56
gtatctggcc acctgatgtg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  cJUN F primer

<400>  57
acgttttgag gcgagactgt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  cJUN R primer

<400>  58
tctgtttccc tctcgcaact                                                   20


<210>  59
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  FBW7 F primer

<400>  59
agctggagtg gaccagagaa attg                                              24


<210>  60
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  FBW7 R primer

<400>  60
gaatgagagc acgtaaagtg c                                                 21


<210>  61
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PIN1 F primer

<400>  61
ggccgggtgt actacttcaa                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PIN1 R primer

<400>  62
ttggttcggg tgatcttctc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  beta-actin F primer

<400>  63
ggcatcctga ccctcaagta                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  beta-actin R primer

<400>  64
cacacggagc tcgttgtaga                                                   20


<210>  65
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  siRNA anti-PKM2

<400>  65
ctgtgtcaga aaaggacatc c                                                 21


<210>  66
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Artificial PIN1 inhibitor peptide


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  66

Cys Arg Tyr Pro Glu Val Glu Ile Cys 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Artificial PIN1 inhibitor peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Lys is Lys(N-biotinoyl)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ala is Bth : beta-(3-benzothienyl)alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Thr is D-Thr(PO3H2)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Pip : piperidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ala is Nal : beta-(2-naphthyl)alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  67

Lys Ala Ala Ala Thr Xaa Ala Gln 
1               5               


<210>  68
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Artificial PIN1 inhibitor peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Thr is D-Thr(PO3H2)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Pip : piperidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ala is Nal : beta-(2-naphthyl)alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  AMIDATION

<400>  68

Phe Thr Xaa Ala Gln 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Artificial PIN1 inhibitor peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ser is pSer

<220>
<221>  BINDING
<222>  (3)..(4)
<223>  Pseudopeptidic binding Phy[(Z)CHdC]

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  AMIDATION

<400>  69

Phe Phe Ser Pro Arg 
1               5   


