
<110>  Fudan University Shanghai Cancer Center

<120>  ԲϵͳƼƱӦ

<140>  PCT/CN2014/000638
<141>  2014-07-03

<150>  CN 201310400969.3
<151>  2013-09-05
<150>  CN 201410114646.2
<151>  2014-03-25

<160>  12

<210>  1 
<211>  1278 
<212>  DNA 
<213>  Artificial 

<400>  1
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg     60
aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg    120
gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc    180
cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc    240
ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg    300
cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa    360
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct    420
gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct    480
cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg    540
aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt    600
acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat    660
caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt    720
cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc    780
agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt    840
aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg    900
agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga    960
tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac   1020
atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg   1080
ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca   1140
cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt   1200
tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg   1260
agatgtacct tgaaataa                                                 1278

<210>  2 
<211>  425 
<212>  PRT 
<213>  Artificial 

<400>  2
Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      

Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          

Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              

Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  

Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  

Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      

Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         

Ile Thr Glu Leu Arg Val Gln Lys Glu Asp Cys Asn Glu Leu Pro Pro 
        115                 120                 125             

Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr 
    130                 135                 140                 

Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser 
145                 150                 155                 160 

Leu Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu 
                165                 170                 175     

Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp 
            180                 185                 190         

Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr 
        195                 200                 205             

Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly 
    210                 215                 220                 

Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile 
225                 230                 235                 240 

Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn 
                245                 250                 255     

Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe 
            260                 265                 270         

Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly 
        275                 280                 285             

Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys 
    290                 295                 300                 

Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly 
305                 310                 315                 320 

Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln 
                325                 330                 335     

Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val 
            340                 345                 350         

Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser 
        355                 360                 365             

Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile 
    370                 375                 380                 

Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe 
385                 390                 395                 400 

Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp 
                405                 410                 415     

Ile Pro Ala Pro Arg Cys Thr Leu Lys 
            420                 425 

<210>  3 
<211>  1323 
<212>  DNA 
<213>  Artificial  

<400>  3
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg     60
aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg    120
gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc    180
cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc    240
ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg    300
cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa    360
tctggtggcg gtggctccgg cggaggtggg tccggtggcg gcggagaaga ttgcaatgaa    420
cttcctccaa gaagaaatac agaaattctg acaggttcct ggtctgacca aacatatcca    480
gaaggcaccc aggctatcta taaatgccgc cctggatata gatctcttgg aaatgtaata    540
atggtatgca ggaagggaga atgggttgct cttaatccat taaggaaatg tcagaaaagg    600
ccctgtggac atcctggaga tactcctttt ggtactttta cccttacagg aggaaatgtg    660
tttgaatatg gtgtaaaagc tgtgtataca tgtaatgagg ggtatcaatt gctaggtgag    720
attaattacc gtgaatgtga cacagatgga tggaccaatg atattcctat atgtgaagtt    780
gtgaagtgtt taccagtgac agcaccagag aatggaaaaa ttgtcagtag tgcaatggaa    840
ccagatcggg aataccattt tggacaagca gtacggtttg tatgtaactc aggctacaag    900
attgaaggag atgaagaaat gcattgttca gacgatggtt tttggagtaa agagaaacca    960
aagtgtgtgg aaatttcatg caaatcccca gatgttataa atggatctcc tatatctcag   1020
aagattattt ataaggagaa tgaacgattt caatataaat gtaacatggg ttatgaatac   1080
agtgaaagag gagatgctgt atgcactgaa tctggatggc gtccgttgcc ttcatgtgaa   1140
gaaaaatcat gtgataatcc ttatattcca aatggtgact actcaccttt aaggattaaa   1200
cacagaactg gagatgaaat cacgtaccag tgtagaaatg gtttttatcc tgcaacccgg   1260
ggaaatacag caaaatgcac aagtactggc tggatacctg ctccgagatg taccttgaaa   1320
taa                                                                 1323

<210>  4 
<211>  440 
<212>  PRT 
<213>  Artificial  

<400>  4
Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      

Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          

Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              

Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  

Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  

Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      

Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         

Ile Thr Glu Leu Arg Val Gln Lys Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             

Gly Gly Ser Gly Gly Gly Gly Glu Asp Cys Asn Glu Leu Pro Pro Arg 
    130                 135                 140                 

Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
145                 150                 155                 160 

Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
                165                 170                 175     

Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
            180                 185                 190         

Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
        195                 200                 205             

Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
    210                 215                 220                 

Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
225                 230                 235                 240 

Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
                245                 250                 255     

Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
            260                 265                 270         

Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
        275                 280                 285             

Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
    290                 295                 300                 

Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
305                 310                 315                 320 

Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
                325                 330                 335     

Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
            340                 345                 350         

Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
        355                 360                 365             

Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
    370                 375                 380                 


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
385                 390                 395                 400 

His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
                405                 410                 415     

Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
            420                 425                 430         

Pro Ala Pro Arg Cys Thr Leu Lys 
        435                 440 

<210>  5 
<211>  1200 
<212>  DNA 
<213>  Artificial 

<400>  5
atggggatct tactgggcct gctactcctg gggcacctaa cagtggacac ttatggccgt     60
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc    120
tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt    180
ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca    240
aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg    300
agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct    360
gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtccagaa actctctgtc    420
tccaagccca cagtgacaac tggcagcggt tatggcttca cggtgcccca gggaatgagg    480
attagccttc aatgccaggc tcggggttct cctcccatca gttatatttg gtataagcaa    540
cagactaata accaggaacc catcaaagta gcaaccctaa gtaccttact cttcaagcct    600
gcggtgatag ccgactcagg ctcctatttc tgcactgcca agggccaggt tggctctgag    660
cagcacagcg acattgtgaa gtttgtggtc aaagactcct caaagctact caagaccaag    720
actgaggcac ctacaaccat gacatacccc ttgaaagcaa catctacagt gaagcagtcc    780
tgggactgga ccactgacat ggatggctac cttggagaga ccagtgctgg gccaggaaag    840
agcctgcctg tctttgccat catcctcatc atctccttgt gctgtatggt ggtttttacc    900
atggcctata tcatgctctg tcggaagaca tcccaacaag agcatgtcta cgaagcagcc    960
agggcacatg ccagagaggc caacgactct ggagaaacca tgagggtggc catcttcgca   1020
agtggctgct ccagtgatga gccaacttcc cagaatctgg gcaacaacta ctctgatgag   1080
ccctgcatag gacaggagta ccagatcatc gcccagatca atggcaacta cgcccgcctg   1140
ctggacacag ttcctctgga ttatgagttt ctggccactg agggcaaaag tgtctgttaa   1200

<210>  6 
<211>  399 
<212>  PRT 
<213>  Artificial 

<400>  6
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      

Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          

Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              

Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  

Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  

Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      

Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         

Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             

Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 

Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 

Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     

Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         

Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             

Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 

Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 

Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     

Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         

Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             

Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 

Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 

Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     

Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         

Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             

Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 

Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 

<210>  7 
<211>  3696 
<212>  DNA 
<213>  Artificial  

<400>  7
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat     60
tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa    120
acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga    180
aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt    240
cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga    300
ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg    360
ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata    420
tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt    480
gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca    540
ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa    600
gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct    660
atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt    720
tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct    780
tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta    840
aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct    900
gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt    960
accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg   1020
cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat   1080
tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg   1140
ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa   1200
aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac   1260
gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc   1320
agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt   1380
tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga   1440
tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca   1500
gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa   1560
aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat   1620
gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat   1680
ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct   1740
gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga   1800
tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc   1860
ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat   1920
gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat   1980
cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact   2040
ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc   2100
tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca   2160
gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa   2220
cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata   2280
cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga   2340
tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa   2400
gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct   2460
cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa   2520
gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca   2580
ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc   2640
attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact   2700
tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg   2760
agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt   2820
gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt   2880
gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac   2940
cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc   3000
atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca   3060
tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg   3120
ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg   3180
tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct   3240
tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct   3300
caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt   3360
acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac   3420
ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca   3480
ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca   3540
ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg   3600
tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat   3660
gggaaactgg agtatccaac ttgtgcaaaa agatag                             3696

<210>  8 
<211>  1231 
<212>  PRT 
<213>  Artificial 

<400>  8
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      

Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          

Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              

Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  

Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  

Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      

Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         

Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             

Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 

Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 

Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     

Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         

Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             

Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 

Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 

Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     

Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         

Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             

Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 

Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 

Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     

His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         

Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             

Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 

Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 

Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     

His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         

Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             

Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 

Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 

Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     

Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         

Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             

Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 

Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 

Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     

His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         

Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             

Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 

Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 

Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     

Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         

Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             

Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 

Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 

Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     

Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         

Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             

Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 

Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 

Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     

Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         

Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             

Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 

Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 

Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     

Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         

Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             

Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 

Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 

Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     

Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         

Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             

Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             

Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             

Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             

Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             

Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             

Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             

Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             

Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             

Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             

Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             

Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             

Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             

Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             

Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             

Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     

<210>  9 
<211>  357 
<212>  DNA 
<213>  Artificial 

<400>  9
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat     60
cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta    120
caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag    180
caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc    240
caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag    300
actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaa       357

<210>  10 
<211>  119 
<212>  PRT 
<213>  Artificial 

<400>  10
Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      

Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          

Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              

Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  

Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  

Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      

Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         

Thr Glu Leu Arg Val Gln Lys 
        115                 

<210>  11 
<211>  915 
<212>  DNA 
<213>  Artificial 

<400>  11
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct     60
gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct    120
cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg    180
aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt    240
acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat    300
caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt    360
cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc    420
agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt    480
aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg    540
agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga    600
tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac    660
atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg    720
ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca    780
cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt    840
tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg    900
agatgtacct tgaaa                                                     915

<210>  12 
<211>  305 
<212>  PRT 
<213>  Artificial 

<400>  12
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      

Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          

Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              

Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  

Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  

Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      

Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         

Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             

Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 

Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 

Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     

Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         

Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             

Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 

Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 

Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     

Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         

Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             

Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 

Lys 
305 



