                         SEQUENCE LISTING

<110>  GlobeImmune, Inc.
       Colorado State University Research Foundation
       King, Thomas H.
       Guo, Zhimin H.
       Orme, Ian M.
 
<120>  Compositions and Methods for the Treatment or Prevention of 
       Tuberculosis

<130>  3923-45-PCT

<150>  62/016,541
<151>  2014-06-24

<150>  61/872,498
<151>  2013-08-30

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Met Ala Asp Glu Ala Pro 
1               5       


<210>  2
<211>  89
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Ser Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  


<210>  3
<211>  89
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  


<210>  4
<211>  129
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  4

Ser Ala Ala Gly Val Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr 
1               5                   10                  15      


Leu Leu Glu Thr Leu Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp 
            20                  25                  30          


Glu Leu Arg Arg Arg Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg 
        35                  40                  45              


Thr Leu Gln Ser Met Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr 
    50                  55                  60                  


Asp Thr Gly Glu Ser Val Tyr Arg Arg Cys Ser Glu His His His His 
65                  70                  75                  80  


His Leu Val Cys Arg Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His 
                85                  90                  95      


Glu Val Glu Ala Trp Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser 
            100                 105                 110         


Asp Val Ser His Thr Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg 
        115                 120                 125             


Ser 
    


<210>  5
<211>  452
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (13)..(444)

<400>  5
gaattcgcca cc atg gcc gat gaa gcc cca act agt tct gct gct ggt gtt       51
              Met Ala Asp Glu Ala Pro Thr Ser Ser Ala Ala Gly Val         
              1               5                   10                      

aga tcc act aga caa aga gct gct att tca act ctc ctt gag aca ttg         99
Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu Glu Thr Leu           
    15                  20                  25                            

gac gac ttt aga tcc gcg cag gaa cta cat gac gaa ctt cgt aga aga        147
Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp Glu Leu Arg Arg Arg           
30                  35                  40                  45            

ggg gag aat ata gga ctg acc acg gtc tat agg aca ttg caa agc atg        195
Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Met           
                50                  55                  60                

gct tcc tct ggt tta gta gat aca ttg cat aca gat act gga gaa tct        243
Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr Asp Thr Gly Glu Ser           
            65                  70                  75                    

gta tac cga aga tgt tct gaa cac cat cac cac cac tta gtc tgt aga        291
Val Tyr Arg Arg Cys Ser Glu His His His His His Leu Val Cys Arg           
        80                  85                  90                        

tca tgc ggc tct act atc gaa gtt ggt gat cat gaa gtg gaa gcc tgg        339
Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His Glu Val Glu Ala Trp           
    95                  100                 105                           

gca gca gaa gtg gca acc aaa cat ggt ttt agt gat gtt tct cat aca        387
Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser Asp Val Ser His Thr           
110                 115                 120                 125           

atc gag att ttc ggc aca tgt tca gat tgc aga tca cat cac cac cat        435
Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg Ser His His His His           
                130                 135                 140               

cac cat tag gcggccgc                                                   452
His His                                                                   
                                                                          


<210>  6
<211>  143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Asp Glu Ala Pro Thr Ser Ser Ala Ala Gly Val Arg Ser Thr 
1               5                   10                  15      


Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu Glu Thr Leu Asp Asp Phe 
            20                  25                  30          


Arg Ser Ala Gln Glu Leu His Asp Glu Leu Arg Arg Arg Gly Glu Asn 
        35                  40                  45              


Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Met Ala Ser Ser 
    50                  55                  60                  


Gly Leu Val Asp Thr Leu His Thr Asp Thr Gly Glu Ser Val Tyr Arg 
65                  70                  75                  80  


Arg Cys Ser Glu His His His His His Leu Val Cys Arg Ser Cys Gly 
                85                  90                  95      


Ser Thr Ile Glu Val Gly Asp His Glu Val Glu Ala Trp Ala Ala Glu 
            100                 105                 110         


Val Ala Thr Lys His Gly Phe Ser Asp Val Ser His Thr Ile Glu Ile 
        115                 120                 125             


Phe Gly Thr Cys Ser Asp Cys Arg Ser His His His His His His 
    130                 135                 140             


<210>  7
<211>  229
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  7

Asn Glu Leu Val Asp Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr Asp 
1               5                   10                  15      


Leu Glu Glu Glu Gly Val Thr Pro Leu Arg Ala Arg Ile Ala Glu Arg 
            20                  25                  30          


Leu Asp Gln Ser Gly Pro Thr Val Ser Gln Thr Val Ser Arg Met Glu 
        35                  40                  45              


Arg Asp Gly Leu Leu Arg Val Ala Gly Asp Arg His Leu Glu Leu Thr 
    50                  55                  60                  


Glu Lys Gly Arg Ala Leu Ala Ile Ala Val Met Arg Lys His Arg Leu 
65                  70                  75                  80  


Ala Glu Arg Leu Leu Val Asp Val Ile Gly Leu Pro Trp Glu Glu Val 
                85                  90                  95      


His Ala Glu Ala Cys Arg Trp Glu His Val Met Ser Glu Asp Val Glu 
            100                 105                 110         


Arg Arg Leu Val Lys Val Leu Asn Asn Pro Thr Thr Ser Pro Phe Gly 
        115                 120                 125             


Asn Pro Ile Pro Gly Leu Val Glu Leu Gly Val Gly Pro Glu Pro Gly 
    130                 135                 140                 


Ala Asp Asp Ala Asn Leu Val Arg Leu Thr Glu Leu Pro Ala Gly Ser 
145                 150                 155                 160 


Pro Val Ala Val Val Val Arg Gln Leu Thr Glu His Val Gln Gly Asp 
                165                 170                 175     


Ile Asp Leu Ile Thr Arg Leu Lys Asp Ala Gly Val Val Pro Asn Ala 
            180                 185                 190         


Arg Val Thr Val Glu Thr Thr Pro Gly Gly Gly Val Thr Ile Val Ile 
        195                 200                 205             


Pro Gly His Glu Asn Val Thr Leu Pro His Glu Met Ala His Ala Val 
    210                 215                 220                 


Lys Val Glu Lys Val 
225                 


<210>  8
<211>  752
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (13)..(744)

<400>  8
gaattcgcca cc atg gcg gac gag gcg cct act agt aat gaa tta gta gac       51
              Met Ala Asp Glu Ala Pro Thr Ser Asn Glu Leu Val Asp         
              1               5                   10                      

acc act gaa atg tat ctt aga aca ata tac gac tta gag gaa gag ggc         99
Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu Glu Glu Gly           
    15                  20                  25                            

gtg acc cca tta aga gcc aga atc gcc gaa aga tta gac caa tcc ggt        147
Val Thr Pro Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp Gln Ser Gly           
30                  35                  40                  45            

cca act gtt tct caa aca gtg tct agg atg gaa aga gat ggt ttg tta        195
Pro Thr Val Ser Gln Thr Val Ser Arg Met Glu Arg Asp Gly Leu Leu           
                50                  55                  60                

agg gtt gct gga gat cgt cac ctc gaa ctc aca gag aaa ggt aga gct        243
Arg Val Ala Gly Asp Arg His Leu Glu Leu Thr Glu Lys Gly Arg Ala           
            65                  70                  75                    

ttg gca atc gca gtc atg aga aag cat aga cta gcg gaa cga ttg cta        291
Leu Ala Ile Ala Val Met Arg Lys His Arg Leu Ala Glu Arg Leu Leu           
        80                  85                  90                        

gtg gac gtg atc gga ctg cct tgg gaa gag gtc cat gct gaa gca tgt        339
Val Asp Val Ile Gly Leu Pro Trp Glu Glu Val His Ala Glu Ala Cys           
    95                  100                 105                           

aga tgg gaa cat gtt atg tct gag gat gta gag aga aga ttg gtc aaa        387
Arg Trp Glu His Val Met Ser Glu Asp Val Glu Arg Arg Leu Val Lys           
110                 115                 120                 125           

gta ttg aat aat cca acc aca tca cct ttt gga aac cct att cct ggg        435
Val Leu Asn Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro Ile Pro Gly           
                130                 135                 140               

cta gtt gaa ctt ggt gtg ggt cct gaa cca ggc gca gat gat gcg aat        483
Leu Val Glu Leu Gly Val Gly Pro Glu Pro Gly Ala Asp Asp Ala Asn           
            145                 150                 155                   

ctg gta aga ttg aca gaa tta cca gca ggg tca cca gtt gca gtt gtt        531
Leu Val Arg Leu Thr Glu Leu Pro Ala Gly Ser Pro Val Ala Val Val           
        160                 165                 170                       

gta aga caa ctg acg gaa cac gtg cag ggt gat att gat ctt atc aca        579
Val Arg Gln Leu Thr Glu His Val Gln Gly Asp Ile Asp Leu Ile Thr           
    175                 180                 185                           

aga ttg aag gac gct ggt gtt gta cca aac gcc cgt gtc act gtt gaa        627
Arg Leu Lys Asp Ala Gly Val Val Pro Asn Ala Arg Val Thr Val Glu           
190                 195                 200                 205           

aca act cct gga ggt ggc gtc aca att gtt ata cca ggc cac gaa aac        675
Thr Thr Pro Gly Gly Gly Val Thr Ile Val Ile Pro Gly His Glu Asn           
                210                 215                 220               

gtt act ctt cca cat gaa atg gcc cat gct gta aaa gtc gag aag gtt        723
Val Thr Leu Pro His Glu Met Ala His Ala Val Lys Val Glu Lys Val           
            225                 230                 235                   

cat cac cac cat cac cat tag gcggccgc                                   752
His His His His His His                                                   
        240                                                               


<210>  9
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  9

Met Ala Asp Glu Ala Pro Thr Ser Asn Glu Leu Val Asp Thr Thr Glu 
1               5                   10                  15      


Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu Glu Glu Gly Val Thr Pro 
            20                  25                  30          


Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp Gln Ser Gly Pro Thr Val 
        35                  40                  45              


Ser Gln Thr Val Ser Arg Met Glu Arg Asp Gly Leu Leu Arg Val Ala 
    50                  55                  60                  


Gly Asp Arg His Leu Glu Leu Thr Glu Lys Gly Arg Ala Leu Ala Ile 
65                  70                  75                  80  


Ala Val Met Arg Lys His Arg Leu Ala Glu Arg Leu Leu Val Asp Val 
                85                  90                  95      


Ile Gly Leu Pro Trp Glu Glu Val His Ala Glu Ala Cys Arg Trp Glu 
            100                 105                 110         


His Val Met Ser Glu Asp Val Glu Arg Arg Leu Val Lys Val Leu Asn 
        115                 120                 125             


Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro Ile Pro Gly Leu Val Glu 
    130                 135                 140                 


Leu Gly Val Gly Pro Glu Pro Gly Ala Asp Asp Ala Asn Leu Val Arg 
145                 150                 155                 160 


Leu Thr Glu Leu Pro Ala Gly Ser Pro Val Ala Val Val Val Arg Gln 
                165                 170                 175     


Leu Thr Glu His Val Gln Gly Asp Ile Asp Leu Ile Thr Arg Leu Lys 
            180                 185                 190         


Asp Ala Gly Val Val Pro Asn Ala Arg Val Thr Val Glu Thr Thr Pro 
        195                 200                 205             


Gly Gly Gly Val Thr Ile Val Ile Pro Gly His Glu Asn Val Thr Leu 
    210                 215                 220                 


Pro His Glu Met Ala His Ala Val Lys Val Glu Lys Val His His His 
225                 230                 235                 240 


His His His 
            


<210>  10
<211>  147
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  10

Val Ser Ser Ile Pro Asp Tyr Ala Glu Gln Leu Arg Thr Ala Asp Leu 
1               5                   10                  15      


Arg Val Thr Arg Pro Arg Val Ala Val Leu Glu Ala Val Asn Ala His 
            20                  25                  30          


Pro His Ala Asp Thr Glu Thr Ile Phe Gly Ala Val Arg Phe Ala Leu 
        35                  40                  45              


Pro Asp Val Ser Arg Gln Ala Val Tyr Asp Val Leu His Ala Leu Thr 
    50                  55                  60                  


Ala Ala Gly Leu Val Arg Lys Ile Gln Pro Ser Gly Ser Val Ala Arg 
65                  70                  75                  80  


Tyr Glu Ser Arg Val Gly Asp Asn His His His Ile Val Cys Arg Ser 
                85                  90                  95      


Cys Gly Val Ile Ala Asp Val Asp Cys Ala Val Gly Glu Ala Pro Cys 
            100                 105                 110         


Leu Thr Ala Ser Asp His Asn Gly Phe Leu Leu Asp Glu Ala Glu Val 
        115                 120                 125             


Ile Tyr Trp Gly Leu Cys Pro Asp Cys Ser Ile Ser Asp Thr Ser Arg 
    130                 135                 140                 


Ser His Pro 
145         


<210>  11
<211>  506
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (13)..(498)

<400>  11
gaattcgcca cc atg gcg gac gag gcg cct act agt gtg tca tca att cct       51
              Met Ala Asp Glu Ala Pro Thr Ser Val Ser Ser Ile Pro         
              1               5                   10                      

gat tac gca gag cag ctc aga acc gct gat ctg aga gta aca aga cca         99
Asp Tyr Ala Glu Gln Leu Arg Thr Ala Asp Leu Arg Val Thr Arg Pro           
    15                  20                  25                            

agg gtc gcc gtt tta gaa gct gtt aat gca cat cca cat gca gat aca        147
Arg Val Ala Val Leu Glu Ala Val Asn Ala His Pro His Ala Asp Thr           
30                  35                  40                  45            

gaa act ata ttt ggc gct gta aga ttc gcg tta cca gat gtt tcc cgt        195
Glu Thr Ile Phe Gly Ala Val Arg Phe Ala Leu Pro Asp Val Ser Arg           
                50                  55                  60                

caa gcc gtc tac gat gta ttg cac gct cta aca gcc gct ggc ttg gtc        243
Gln Ala Val Tyr Asp Val Leu His Ala Leu Thr Ala Ala Gly Leu Val           
            65                  70                  75                    

cga aaa atc caa cca tct ggg tct gtc gct aga tat gaa agt aga gtg        291
Arg Lys Ile Gln Pro Ser Gly Ser Val Ala Arg Tyr Glu Ser Arg Val           
        80                  85                  90                        

ggt gac aat cat cat cat atc gtt tgc aga agc tgt ggt gtg att gca        339
Gly Asp Asn His His His Ile Val Cys Arg Ser Cys Gly Val Ile Ala           
    95                  100                 105                           

gat gtt gac tgc gcg gtt gga gaa gca cca tgt ctt act gca tct gat        387
Asp Val Asp Cys Ala Val Gly Glu Ala Pro Cys Leu Thr Ala Ser Asp           
110                 115                 120                 125           

cac aac gga ttt ttg cta gac gaa gct gaa gtt atc tac tgg ggt ctt        435
His Asn Gly Phe Leu Leu Asp Glu Ala Glu Val Ile Tyr Trp Gly Leu           
                130                 135                 140               

tgt cct gac tgt tct att tct gat acg tca aga tcc cac cct cac cat        483
Cys Pro Asp Cys Ser Ile Ser Asp Thr Ser Arg Ser His Pro His His           
            145                 150                 155                   

cat cac cat cac tag gcggccgc                                           506
His His His His                                                           
        160                                                               


<210>  12
<211>  161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  12

Met Ala Asp Glu Ala Pro Thr Ser Val Ser Ser Ile Pro Asp Tyr Ala 
1               5                   10                  15      


Glu Gln Leu Arg Thr Ala Asp Leu Arg Val Thr Arg Pro Arg Val Ala 
            20                  25                  30          


Val Leu Glu Ala Val Asn Ala His Pro His Ala Asp Thr Glu Thr Ile 
        35                  40                  45              


Phe Gly Ala Val Arg Phe Ala Leu Pro Asp Val Ser Arg Gln Ala Val 
    50                  55                  60                  


Tyr Asp Val Leu His Ala Leu Thr Ala Ala Gly Leu Val Arg Lys Ile 
65                  70                  75                  80  


Gln Pro Ser Gly Ser Val Ala Arg Tyr Glu Ser Arg Val Gly Asp Asn 
                85                  90                  95      


His His His Ile Val Cys Arg Ser Cys Gly Val Ile Ala Asp Val Asp 
            100                 105                 110         


Cys Ala Val Gly Glu Ala Pro Cys Leu Thr Ala Ser Asp His Asn Gly 
        115                 120                 125             


Phe Leu Leu Asp Glu Ala Glu Val Ile Tyr Trp Gly Leu Cys Pro Asp 
    130                 135                 140                 


Cys Ser Ile Ser Asp Thr Ser Arg Ser His Pro His His His His His 
145                 150                 155                 160 


His 
    


<210>  13
<211>  505
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic sequence

<400>  13

Ser Ala Ala Gly Val Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr 
1               5                   10                  15      


Leu Leu Glu Thr Leu Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp 
            20                  25                  30          


Glu Leu Arg Arg Arg Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg 
        35                  40                  45              


Thr Leu Gln Ser Met Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr 
    50                  55                  60                  


Asp Thr Gly Glu Ser Val Tyr Arg Arg Cys Ser Glu His His His His 
65                  70                  75                  80  


His Leu Val Cys Arg Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His 
                85                  90                  95      


Glu Val Glu Ala Trp Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser 
            100                 105                 110         


Asp Val Ser His Thr Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg 
        115                 120                 125             


Ser Asn Glu Leu Val Asp Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr 
    130                 135                 140                 


Asp Leu Glu Glu Glu Gly Val Thr Pro Leu Arg Ala Arg Ile Ala Glu 
145                 150                 155                 160 


Arg Leu Asp Gln Ser Gly Pro Thr Val Ser Gln Thr Val Ser Arg Met 
                165                 170                 175     


Glu Arg Asp Gly Leu Leu Arg Val Ala Gly Asp Arg His Leu Glu Leu 
            180                 185                 190         


Thr Glu Lys Gly Arg Ala Leu Ala Ile Ala Val Met Arg Lys His Arg 
        195                 200                 205             


Leu Ala Glu Arg Leu Leu Val Asp Val Ile Gly Leu Pro Trp Glu Glu 
    210                 215                 220                 


Val His Ala Glu Ala Cys Arg Trp Glu His Val Met Ser Glu Asp Val 
225                 230                 235                 240 


Glu Arg Arg Leu Val Lys Val Leu Asn Asn Pro Thr Thr Ser Pro Phe 
                245                 250                 255     


Gly Asn Pro Ile Pro Gly Leu Val Glu Leu Gly Val Gly Pro Glu Pro 
            260                 265                 270         


Gly Ala Asp Asp Ala Asn Leu Val Arg Leu Thr Glu Leu Pro Ala Gly 
        275                 280                 285             


Ser Pro Val Ala Val Val Val Arg Gln Leu Thr Glu His Val Gln Gly 
    290                 295                 300                 


Asp Ile Asp Leu Ile Thr Arg Leu Lys Asp Ala Gly Val Val Pro Asn 
305                 310                 315                 320 


Ala Arg Val Thr Val Glu Thr Thr Pro Gly Gly Gly Val Thr Ile Val 
                325                 330                 335     


Ile Pro Gly His Glu Asn Val Thr Leu Pro His Glu Met Ala His Ala 
            340                 345                 350         


Val Lys Val Glu Lys Val Val Ser Ser Ile Pro Asp Tyr Ala Glu Gln 
        355                 360                 365             


Leu Arg Thr Ala Asp Leu Arg Val Thr Arg Pro Arg Val Ala Val Leu 
    370                 375                 380                 


Glu Ala Val Asn Ala His Pro His Ala Asp Thr Glu Thr Ile Phe Gly 
385                 390                 395                 400 


Ala Val Arg Phe Ala Leu Pro Asp Val Ser Arg Gln Ala Val Tyr Asp 
                405                 410                 415     


Val Leu His Ala Leu Thr Ala Ala Gly Leu Val Arg Lys Ile Gln Pro 
            420                 425                 430         


Ser Gly Ser Val Ala Arg Tyr Glu Ser Arg Val Gly Asp Asn His His 
        435                 440                 445             


His Ile Val Cys Arg Ser Cys Gly Val Ile Ala Asp Val Asp Cys Ala 
    450                 455                 460                 


Val Gly Glu Ala Pro Cys Leu Thr Ala Ser Asp His Asn Gly Phe Leu 
465                 470                 475                 480 


Leu Asp Glu Ala Glu Val Ile Tyr Trp Gly Leu Cys Pro Asp Cys Ser 
                485                 490                 495     


Ile Ser Asp Thr Ser Arg Ser His Pro 
            500                 505 


<210>  14
<211>  1580
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (13)..(1572)

<400>  14
gaattcgcca cc atg gcc gat gaa gcc cca act agt tct gct gct ggt gtt       51
              Met Ala Asp Glu Ala Pro Thr Ser Ser Ala Ala Gly Val         
              1               5                   10                      

aga tcc act aga caa aga gct gct att tca act ctc ctt gag aca ttg         99
Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu Glu Thr Leu           
    15                  20                  25                            

gac gac ttt aga tcc gcg cag gaa cta cat gac gaa ctt cgt aga aga        147
Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp Glu Leu Arg Arg Arg           
30                  35                  40                  45            

ggg gag aat ata gga ctg acc acg gtc tat agg aca ttg caa agc atg        195
Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Met           
                50                  55                  60                

gct tcc tct ggt tta gta gat aca ttg cat aca gat act gga gaa tct        243
Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr Asp Thr Gly Glu Ser           
            65                  70                  75                    

gta tac cga aga tgt tct gaa cac cat cac cac cac tta gtc tgt aga        291
Val Tyr Arg Arg Cys Ser Glu His His His His His Leu Val Cys Arg           
        80                  85                  90                        

tca tgc ggc tct act atc gaa gtt ggt gat cat gaa gtg gaa gcc tgg        339
Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His Glu Val Glu Ala Trp           
    95                  100                 105                           

gca gca gaa gtg gca acc aaa cat ggt ttt agt gat gtt tct cat aca        387
Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser Asp Val Ser His Thr           
110                 115                 120                 125           

atc gag att ttc ggc aca tgt tca gat tgc aga tca aat gaa tta gta        435
Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg Ser Asn Glu Leu Val           
                130                 135                 140               

gac acc act gaa atg tat ctt aga aca ata tac gac tta gag gaa gag        483
Asp Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu Glu Glu           
            145                 150                 155                   

ggc gtg acc cca tta aga gcc aga atc gcc gaa aga tta gac caa tcc        531
Gly Val Thr Pro Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp Gln Ser           
        160                 165                 170                       

ggt cca act gtt tct caa aca gtg tct agg atg gaa aga gat ggt ttg        579
Gly Pro Thr Val Ser Gln Thr Val Ser Arg Met Glu Arg Asp Gly Leu           
    175                 180                 185                           

tta agg gtt gct gga gat cgt cac ctc gaa ctc aca gag aaa ggt aga        627
Leu Arg Val Ala Gly Asp Arg His Leu Glu Leu Thr Glu Lys Gly Arg           
190                 195                 200                 205           

gct ttg gca atc gca gtc atg aga aag cat aga cta gcg gaa cga ttg        675
Ala Leu Ala Ile Ala Val Met Arg Lys His Arg Leu Ala Glu Arg Leu           
                210                 215                 220               

cta gtg gac gtg atc gga ctg cct tgg gaa gag gtc cat gct gaa gca        723
Leu Val Asp Val Ile Gly Leu Pro Trp Glu Glu Val His Ala Glu Ala           
            225                 230                 235                   

tgt aga tgg gaa cat gtt atg tct gag gat gta gag aga aga ttg gtc        771
Cys Arg Trp Glu His Val Met Ser Glu Asp Val Glu Arg Arg Leu Val           
        240                 245                 250                       

aaa gta ttg aat aat cca acc aca tca cct ttt gga aac cct att cct        819
Lys Val Leu Asn Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro Ile Pro           
    255                 260                 265                           

ggg cta gtt gaa ctt ggt gtg ggt cct gaa cca ggc gca gat gat gcg        867
Gly Leu Val Glu Leu Gly Val Gly Pro Glu Pro Gly Ala Asp Asp Ala           
270                 275                 280                 285           

aat ctg gta aga ttg aca gaa tta cca gca ggg tca cca gtt gca gtt        915
Asn Leu Val Arg Leu Thr Glu Leu Pro Ala Gly Ser Pro Val Ala Val           
                290                 295                 300               

gtt gta aga caa ctg acg gaa cac gtg cag ggt gat att gat ctt atc        963
Val Val Arg Gln Leu Thr Glu His Val Gln Gly Asp Ile Asp Leu Ile           
            305                 310                 315                   

aca aga ttg aag gac gct ggt gtt gta cca aac gcc cgt gtc act gtt       1011
Thr Arg Leu Lys Asp Ala Gly Val Val Pro Asn Ala Arg Val Thr Val           
        320                 325                 330                       

gaa aca act cct gga ggt ggc gtc aca att gtt ata cca ggc cac gaa       1059
Glu Thr Thr Pro Gly Gly Gly Val Thr Ile Val Ile Pro Gly His Glu           
    335                 340                 345                           

aac gtt act ctt cca cat gaa atg gcc cat gct gta aaa gtc gag aag       1107
Asn Val Thr Leu Pro His Glu Met Ala His Ala Val Lys Val Glu Lys           
350                 355                 360                 365           

gtt gtg tca tca att cct gat tac gca gag cag ctc aga acc gct gat       1155
Val Val Ser Ser Ile Pro Asp Tyr Ala Glu Gln Leu Arg Thr Ala Asp           
                370                 375                 380               

ctg aga gta aca aga cca agg gtc gcc gtt tta gaa gct gtt aat gca       1203
Leu Arg Val Thr Arg Pro Arg Val Ala Val Leu Glu Ala Val Asn Ala           
            385                 390                 395                   

cat cca cat gca gat aca gaa act ata ttt ggc gct gta aga ttc gcg       1251
His Pro His Ala Asp Thr Glu Thr Ile Phe Gly Ala Val Arg Phe Ala           
        400                 405                 410                       

tta cca gat gtt tcc cgt caa gcc gtc tac gat gta ttg cac gct cta       1299
Leu Pro Asp Val Ser Arg Gln Ala Val Tyr Asp Val Leu His Ala Leu           
    415                 420                 425                           

aca gcc gct ggc ttg gtc cga aaa atc caa cca tct ggg tct gtc gct       1347
Thr Ala Ala Gly Leu Val Arg Lys Ile Gln Pro Ser Gly Ser Val Ala           
430                 435                 440                 445           

aga tat gaa agt aga gtg ggt gac aat cat cat cat atc gtt tgc aga       1395
Arg Tyr Glu Ser Arg Val Gly Asp Asn His His His Ile Val Cys Arg           
                450                 455                 460               

agc tgt ggt gtg att gca gat gtt gac tgc gcg gtt gga gaa gca cca       1443
Ser Cys Gly Val Ile Ala Asp Val Asp Cys Ala Val Gly Glu Ala Pro           
            465                 470                 475                   

tgt ctt act gca tct gat cac aac gga ttt ttg cta gac gaa gct gaa       1491
Cys Leu Thr Ala Ser Asp His Asn Gly Phe Leu Leu Asp Glu Ala Glu           
        480                 485                 490                       

gtt atc tac tgg ggt ctt tgt cct gac tgt tct att tct gat acg tca       1539
Val Ile Tyr Trp Gly Leu Cys Pro Asp Cys Ser Ile Ser Asp Thr Ser           
    495                 500                 505                           

aga tcc cac cct cac cat cat cac cat cac tag gcggccgc                  1580
Arg Ser His Pro His His His His His His                                   
510                 515                                                   


<210>  15
<211>  519
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Met Ala Asp Glu Ala Pro Thr Ser Ser Ala Ala Gly Val Arg Ser Thr 
1               5                   10                  15      


Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu Glu Thr Leu Asp Asp Phe 
            20                  25                  30          


Arg Ser Ala Gln Glu Leu His Asp Glu Leu Arg Arg Arg Gly Glu Asn 
        35                  40                  45              


Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Met Ala Ser Ser 
    50                  55                  60                  


Gly Leu Val Asp Thr Leu His Thr Asp Thr Gly Glu Ser Val Tyr Arg 
65                  70                  75                  80  


Arg Cys Ser Glu His His His His His Leu Val Cys Arg Ser Cys Gly 
                85                  90                  95      


Ser Thr Ile Glu Val Gly Asp His Glu Val Glu Ala Trp Ala Ala Glu 
            100                 105                 110         


Val Ala Thr Lys His Gly Phe Ser Asp Val Ser His Thr Ile Glu Ile 
        115                 120                 125             


Phe Gly Thr Cys Ser Asp Cys Arg Ser Asn Glu Leu Val Asp Thr Thr 
    130                 135                 140                 


Glu Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu Glu Glu Gly Val Thr 
145                 150                 155                 160 


Pro Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp Gln Ser Gly Pro Thr 
                165                 170                 175     


Val Ser Gln Thr Val Ser Arg Met Glu Arg Asp Gly Leu Leu Arg Val 
            180                 185                 190         


Ala Gly Asp Arg His Leu Glu Leu Thr Glu Lys Gly Arg Ala Leu Ala 
        195                 200                 205             


Ile Ala Val Met Arg Lys His Arg Leu Ala Glu Arg Leu Leu Val Asp 
    210                 215                 220                 


Val Ile Gly Leu Pro Trp Glu Glu Val His Ala Glu Ala Cys Arg Trp 
225                 230                 235                 240 


Glu His Val Met Ser Glu Asp Val Glu Arg Arg Leu Val Lys Val Leu 
                245                 250                 255     


Asn Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro Ile Pro Gly Leu Val 
            260                 265                 270         


Glu Leu Gly Val Gly Pro Glu Pro Gly Ala Asp Asp Ala Asn Leu Val 
        275                 280                 285             


Arg Leu Thr Glu Leu Pro Ala Gly Ser Pro Val Ala Val Val Val Arg 
    290                 295                 300                 


Gln Leu Thr Glu His Val Gln Gly Asp Ile Asp Leu Ile Thr Arg Leu 
305                 310                 315                 320 


Lys Asp Ala Gly Val Val Pro Asn Ala Arg Val Thr Val Glu Thr Thr 
                325                 330                 335     


Pro Gly Gly Gly Val Thr Ile Val Ile Pro Gly His Glu Asn Val Thr 
            340                 345                 350         


Leu Pro His Glu Met Ala His Ala Val Lys Val Glu Lys Val Val Ser 
        355                 360                 365             


Ser Ile Pro Asp Tyr Ala Glu Gln Leu Arg Thr Ala Asp Leu Arg Val 
    370                 375                 380                 


Thr Arg Pro Arg Val Ala Val Leu Glu Ala Val Asn Ala His Pro His 
385                 390                 395                 400 


Ala Asp Thr Glu Thr Ile Phe Gly Ala Val Arg Phe Ala Leu Pro Asp 
                405                 410                 415     


Val Ser Arg Gln Ala Val Tyr Asp Val Leu His Ala Leu Thr Ala Ala 
            420                 425                 430         


Gly Leu Val Arg Lys Ile Gln Pro Ser Gly Ser Val Ala Arg Tyr Glu 
        435                 440                 445             


Ser Arg Val Gly Asp Asn His His His Ile Val Cys Arg Ser Cys Gly 
    450                 455                 460                 


Val Ile Ala Asp Val Asp Cys Ala Val Gly Glu Ala Pro Cys Leu Thr 
465                 470                 475                 480 


Ala Ser Asp His Asn Gly Phe Leu Leu Asp Glu Ala Glu Val Ile Tyr 
                485                 490                 495     


Trp Gly Leu Cys Pro Asp Cys Ser Ile Ser Asp Thr Ser Arg Ser His 
            500                 505                 510         


Pro His His His His His His 
        515                 


<210>  16
<211>  94
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  16

Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala 
1               5                   10                  15      


Ile Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Glu Gly Lys 
            20                  25                  30          


Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp Gly Gly Ser Gly Ser Glu 
        35                  40                  45              


Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu Leu 
    50                  55                  60                  


Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala Gly Gln 
65                  70                  75                  80  


Ala Met Ala Ser Thr Glu Gly Asn Val Thr Gly Met Phe Ala 
                85                  90                  


<210>  17
<211>  347
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (13)..(339)

<400>  17
gaattcgcca cc atg gca gat gaa gcc cca act agt acc gaa cag caa tgg       51
              Met Ala Asp Glu Ala Pro Thr Ser Thr Glu Gln Gln Trp         
              1               5                   10                      

aat ttt gct ggt ata gag gct gcg gcc tct gca atc caa ggc aac gta         99
Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val           
    15                  20                  25                            

aca tca att cat tca ctg tta gac gaa ggt aaa cag agc ttg act aag        147
Thr Ser Ile His Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys           
30                  35                  40                  45            

ttg gct gcc gcc tgg gga ggt tct ggc tcc gag gct tac caa ggg gtt        195
Leu Ala Ala Ala Trp Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val           
                50                  55                  60                

caa caa aaa tgg gat gct acg gca act gaa cta aac aat gct tta caa        243
Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln           
            65                  70                  75                    

aat ctt gct aga aca atc tca gaa gca ggt caa gcg atg gca tct aca        291
Asn Leu Ala Arg Thr Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr           
        80                  85                  90                        

gaa ggt aat gtc aca gga atg ttc gca cac cat cat cac cat cac tag        339
Glu Gly Asn Val Thr Gly Met Phe Ala His His His His His His               
    95                  100                 105                           

gcggccgc                                                               347


<210>  18
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Met Ala Asp Glu Ala Pro Thr Ser Thr Glu Gln Gln Trp Asn Phe Ala 
1               5                   10                  15      


Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile 
            20                  25                  30          


His Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala 
        35                  40                  45              


Ala Trp Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys 
    50                  55                  60                  


Trp Asp Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala 
65                  70                  75                  80  


Arg Thr Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn 
                85                  90                  95      


Val Thr Gly Met Phe Ala His His His His His His 
            100                 105             


<210>  19
<211>  94
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  19

Met Cys Gly Asp Gln Ser Asp His Val Leu Gln His Trp Thr Val Asp 
1               5                   10                  15      


Ile Ser Ile Asp Glu His Glu Gly Leu Thr Arg Ala Lys Ala Arg Leu 
            20                  25                  30          


Arg Trp Arg Glu Lys Glu Leu Val Gly Val Gly Leu Ala Arg Leu Asn 
        35                  40                  45              


Pro Ala Asp Arg Asn Val Pro Glu Ile Gly Asp Glu Leu Ser Val Ala 
    50                  55                  60                  


Arg Ala Leu Ser Asp Leu Gly Lys Arg Met Leu Lys Val Ser Thr His 
65                  70                  75                  80  


Asp Ile Glu Ala Val Thr His Gln Pro Ala Arg Leu Leu Tyr 
                85                  90                  


<210>  20
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (1)..(324)

<400>  20
atg gcc gac gag gca cca act agt tgc gga gat caa tca gac cac gtt         48
Met Ala Asp Glu Ala Pro Thr Ser Cys Gly Asp Gln Ser Asp His Val           
1               5                   10                  15                

tta caa cac tgg acc gta gac att tct atc gat gaa cat gaa ggt ctt         96
Leu Gln His Trp Thr Val Asp Ile Ser Ile Asp Glu His Glu Gly Leu           
            20                  25                  30                    

aca aga gct aaa gct aga ttg aga tgg cgt gaa aag gaa tta gtc ggc        144
Thr Arg Ala Lys Ala Arg Leu Arg Trp Arg Glu Lys Glu Leu Val Gly           
        35                  40                  45                        

gtt ggg cta gct agg tta aat cct gca gat aga aac gtt cca gaa ata        192
Val Gly Leu Ala Arg Leu Asn Pro Ala Asp Arg Asn Val Pro Glu Ile           
    50                  55                  60                            

ggt gat gaa cta tcc gtg gcg aga gcc ctg tct gat ttg ggt aag aga        240
Gly Asp Glu Leu Ser Val Ala Arg Ala Leu Ser Asp Leu Gly Lys Arg           
65                  70                  75                  80            

atg ttg aaa gtc tca act cat gat atc gag gca gta aca cat cag cca        288
Met Leu Lys Val Ser Thr His Asp Ile Glu Ala Val Thr His Gln Pro           
                85                  90                  95                

gct aga ctc ctt tac cac cat cat cac cat cat taa                        324
Ala Arg Leu Leu Tyr His His His His His His                               
            100                 105                                       


<210>  21
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Asp Glu Ala Pro Thr Ser Cys Gly Asp Gln Ser Asp His Val 
1               5                   10                  15      


Leu Gln His Trp Thr Val Asp Ile Ser Ile Asp Glu His Glu Gly Leu 
            20                  25                  30          


Thr Arg Ala Lys Ala Arg Leu Arg Trp Arg Glu Lys Glu Leu Val Gly 
        35                  40                  45              


Val Gly Leu Ala Arg Leu Asn Pro Ala Asp Arg Asn Val Pro Glu Ile 
    50                  55                  60                  


Gly Asp Glu Leu Ser Val Ala Arg Ala Leu Ser Asp Leu Gly Lys Arg 
65                  70                  75                  80  


Met Leu Lys Val Ser Thr His Asp Ile Glu Ala Val Thr His Gln Pro 
                85                  90                  95      


Ala Arg Leu Leu Tyr His His His His His His 
            100                 105         


<210>  22
<211>  331
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  22

Met Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys Ser Arg Val Gln 
1               5                   10                  15      


Leu Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln Pro Trp Arg Trp 
            20                  25                  30          


Ile Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp Lys Asp Arg Val 
        35                  40                  45              


Leu Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu Leu Gly Cys Gly 
    50                  55                  60                  


Ala Val Leu Asp His Phe Arg Val Ala Met Ala Ala Ala Gly Thr Thr 
65                  70                  75                  80  


Ala Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro Leu His Leu Ala 
                85                  90                  95      


Ser Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu Gly His Arg Leu 
            100                 105                 110         


Arg Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg Leu Pro Phe Ala 
        115                 120                 125             


Glu Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu Arg Thr Thr Val 
    130                 135                 140                 


Thr Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp Asp Met Arg Pro 
145                 150                 155                 160 


Glu Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu Arg Leu Tyr Asp 
                165                 170                 175     


Ser Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly Ala Phe Glu Thr 
            180                 185                 190         


Ser Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala Ala Glu Ser Asp 
        195                 200                 205             


Arg Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala Asn Thr Asp Arg 
    210                 215                 220                 


Arg Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu Val Leu Ser Thr 
225                 230                 235                 240 


Tyr Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly Glu Met Leu Ser 
                245                 250                 255     


Ala Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala Thr Cys Thr Leu 
            260                 265                 270         


Thr His Ile Thr Glu Leu His Ala Ser Arg Asp Leu Val Ala Ala Leu 
        275                 280                 285             


Ile Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg Val Gly Leu Ala 
    290                 295                 300                 


Pro Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg Arg Pro Ile Asp 
305                 310                 315                 320 


Glu Val Phe His Val Arg Ala Lys Asp His Arg 
                325                 330     


<210>  23
<211>  1035
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1035)

<400>  23
atg gcc gac gag gca cca act agt cca gat aca atg gtt aca aca gac         48
Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp           
1               5                   10                  15                

gtg att aag agc aga gta caa ttg gcc tgt aga gca cct agt tta cat         96
Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His           
            20                  25                  30                    

aat tca cag cca tgg aga tgg att gca gaa gat cac aca gtc gca ttg        144
Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu           
        35                  40                  45                        

ttt ctc gac aaa gat aga gta cta tac gct acc gat cat tct ggg aga        192
Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg           
    50                  55                  60                            

gaa gca ttg ttg ggt tgc ggt gca gtt ctg gat cac ttt aga gta gcc        240
Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala           
65                  70                  75                  80            

atg gcg gct gcc ggt aca acc gct aac gta gag aga ttc cca aac cct        288
Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro           
                85                  90                  95                

aat gat cca ctc cac tta gct tca atc gat ttt tcc cca gct gat ttc        336
Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe           
            100                 105                 110                   

gtg acg gaa ggc cat aga ctc aga gct gat gcc atc ttg ctt agg agg        384
Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg           
        115                 120                 125                       

aca gat aga tta cct ttc gcc gaa cct cca gac tgg gat tta gta gaa        432
Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu           
    130                 135                 140                           

agt caa ttg cgt act act gtc act gca gat aca gtt aga att gac gtc        480
Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val           
145                 150                 155                 160           

atc gcg gat gac atg cgt cca gaa ctg gca gcc gca tca aaa ctg acc        528
Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr           
                165                 170                 175               

gaa tct ttg aga tta tac gat tct tct tac cat gca gaa cta ttc tgg        576
Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp           
            180                 185                 190                   

tgg act ggc gcc ttt gaa aca tct gag ggg ata cca cat tct tct tta        624
Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu           
        195                 200                 205                       

gtg tca gct gct gaa tct gac aga gtt act ttc gga aga gat ttt cct        672
Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro           
    210                 215                 220                           

gtg gtc gca aat aca gat cgt aga cca gaa ttt ggc cac gac aga tcc        720
Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser           
225                 230                 235                 240           

aaa gtt ctt gtt tta tcc act tat gat aat gaa aga gcc tcc ttg ctg        768
Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu           
                245                 250                 255               

aga tgt gga gag atg cta tca gct gtt ttg cta gat gca act atg gcg        816
Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala           
            260                 265                 270                   

gga tta gct aca tgt act cta acc cat att acg gaa ctt cat gct tca        864
Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser           
        275                 280                 285                       

agg gac ctt gtc gcg gct ttg ata ggt caa ccc gct aca cca caa gca        912
Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala           
    290                 295                 300                           

ctt gtt cgc gtt ggt ttg gct cca gaa atg gag gaa cct cct cct gct        960
Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala           
305                 310                 315                 320           

act cca aga cga cca atc gac gag gtt ttt cat gtg aga gct aag gat       1008
Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp           
                325                 330                 335               

cat aga cac cat cac cat cat cac taa                                   1035
His Arg His His His His His His                                           
            340                                                           


<210>  24
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp 
1               5                   10                  15      


Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His 
            20                  25                  30          


Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu 
        35                  40                  45              


Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg 
    50                  55                  60                  


Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala 
65                  70                  75                  80  


Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro 
                85                  90                  95      


Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe 
            100                 105                 110         


Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg 
        115                 120                 125             


Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu 
    130                 135                 140                 


Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val 
145                 150                 155                 160 


Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr 
                165                 170                 175     


Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp 
            180                 185                 190         


Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu 
        195                 200                 205             


Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro 
    210                 215                 220                 


Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser 
225                 230                 235                 240 


Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu 
                245                 250                 255     


Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala 
            260                 265                 270         


Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser 
        275                 280                 285             


Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala 
    290                 295                 300                 


Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp 
                325                 330                 335     


His Arg His His His His His His 
            340                 


<210>  25
<211>  463
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  25

Met Asn His Leu Thr Thr Leu Asp Ala Gly Phe Leu Lys Ala Glu Asp 
1               5                   10                  15      


Val Asp Arg His Val Ser Leu Ala Ile Gly Ala Leu Ala Val Ile Glu 
            20                  25                  30          


Gly Pro Ala Pro Asp Gln Glu Ala Phe Leu Ser Ser Leu Ala Gln Arg 
        35                  40                  45              


Leu Arg Pro Cys Thr Arg Phe Gly Gln Arg Leu Arg Leu Arg Pro Phe 
    50                  55                  60                  


Asp Leu Gly Ala Pro Lys Trp Val Asp Asp Pro Asp Phe Asp Leu Gly 
65                  70                  75                  80  


Arg His Val Trp Arg Ile Ala Leu Pro Arg Pro Gly Asn Glu Asp Gln 
                85                  90                  95      


Leu Phe Glu Leu Ile Ala Asp Leu Met Ala Arg Arg Leu Asp Arg Gly 
            100                 105                 110         


Arg Pro Leu Trp Glu Val Trp Val Ile Glu Gly Leu Ala Asp Ser Lys 
        115                 120                 125             


Trp Ala Ile Leu Thr Lys Leu His His Cys Met Ala Asp Gly Ile Ala 
    130                 135                 140                 


Ala Thr His Leu Leu Ala Gly Leu Ser Asp Glu Ser Met Ser Asp Ser 
145                 150                 155                 160 


Phe Ala Ser Asn Ile His Thr Thr Met Gln Ser Gln Ser Ala Ser Val 
                165                 170                 175     


Arg Arg Gly Gly Phe Arg Val Asn Pro Ser Glu Ala Leu Thr Ala Ser 
            180                 185                 190         


Thr Ala Val Met Ala Gly Ile Val Arg Ala Ala Lys Gly Ala Ser Glu 
        195                 200                 205             


Ile Ala Ala Gly Val Leu Ser Pro Ala Ala Ser Ser Leu Asn Gly Pro 
    210                 215                 220                 


Ile Ser Asp Leu Arg Arg Tyr Ser Ala Ala Lys Val Pro Leu Ala Asp 
225                 230                 235                 240 


Val Glu Gln Val Cys Arg Lys Phe Asp Val Thr Ile Asn Asp Val Ala 
                245                 250                 255     


Leu Ala Ala Ile Thr Glu Ser Tyr Arg Asn Val Leu Ile Gln Arg Gly 
            260                 265                 270         


Glu Arg Pro Arg Phe Asp Ser Leu Arg Thr Leu Val Pro Val Ser Thr 
        275                 280                 285             


Arg Ser Asn Ser Ala Leu Ser Lys Thr Asp Asn Arg Val Ser Leu Met 
    290                 295                 300                 


Leu Pro Asn Leu Pro Val Asp Gln Glu Asn Pro Leu Gln Arg Leu Arg 
305                 310                 315                 320 


Ile Val His Ser Arg Leu Thr Arg Ala Lys Ala Gly Gly Gln Arg Gln 
                325                 330                 335     


Phe Gly Asn Thr Leu Met Ala Ile Ala Asn Arg Leu Pro Phe Pro Met 
            340                 345                 350         


Thr Ala Trp Ala Val Gly Leu Leu Met Arg Leu Pro Gln Arg Gly Val 
        355                 360                 365             


Val Thr Val Ala Thr Asn Val Pro Gly Pro Arg Arg Pro Leu Gln Ile 
    370                 375                 380                 


Met Gly Arg Arg Val Leu Asp Leu Tyr Pro Val Ser Pro Ile Ala Met 
385                 390                 395                 400 


Gln Leu Arg Thr Ser Val Ala Met Leu Ser Tyr Ala Asp Asp Leu Tyr 
                405                 410                 415     


Phe Gly Ile Leu Ala Asp Tyr Asp Val Val Ala Asp Ala Gly Gln Leu 
            420                 425                 430         


Ala Arg Gly Ile Glu Asp Ala Val Ala Arg Leu Val Ala Ile Ser Lys 
        435                 440                 445             


Arg Arg Lys Val Thr Arg Arg Arg Gly Ala Leu Ser Leu Val Val 
    450                 455                 460             


<210>  26
<211>  1431
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1431)

<400>  26
atg gcc gac gag gca cca act agt aat cac tta aca aca ttg gac gcg         48
Met Ala Asp Glu Ala Pro Thr Ser Asn His Leu Thr Thr Leu Asp Ala           
1               5                   10                  15                

gga ttc ttg aaa gct gaa gat gta gat aga cat gta tca ttg gca att         96
Gly Phe Leu Lys Ala Glu Asp Val Asp Arg His Val Ser Leu Ala Ile           
            20                  25                  30                    

ggt gcc ctt gct gtg att gaa ggc cca gca cct gat cag gaa gct ttc        144
Gly Ala Leu Ala Val Ile Glu Gly Pro Ala Pro Asp Gln Glu Ala Phe           
        35                  40                  45                        

ctg agt tca tta gca caa cgt tta aga cca tgt act aga ttc ggg caa        192
Leu Ser Ser Leu Ala Gln Arg Leu Arg Pro Cys Thr Arg Phe Gly Gln           
    50                  55                  60                            

aga cta aga ctc aga cca ttt gat ctt ggg gcg cca aag tgg gta gat        240
Arg Leu Arg Leu Arg Pro Phe Asp Leu Gly Ala Pro Lys Trp Val Asp           
65                  70                  75                  80            

gat cct gat ttt gat ttg ggc aga cat gtt tgg aga atc gca cta cct        288
Asp Pro Asp Phe Asp Leu Gly Arg His Val Trp Arg Ile Ala Leu Pro           
                85                  90                  95                

aga cca gga aac gag gat caa ttg ttt gaa ttg atc gct gac ctg atg        336
Arg Pro Gly Asn Glu Asp Gln Leu Phe Glu Leu Ile Ala Asp Leu Met           
            100                 105                 110                   

gcc aga agg ctt gac aga ggt agg cca tta tgg gaa gta tgg gtt ata        384
Ala Arg Arg Leu Asp Arg Gly Arg Pro Leu Trp Glu Val Trp Val Ile           
        115                 120                 125                       

gag ggt ttg gcc gat tct aaa tgg gct att ttg acc aaa ctg cat cac        432
Glu Gly Leu Ala Asp Ser Lys Trp Ala Ile Leu Thr Lys Leu His His           
    130                 135                 140                           

tgc atg gca gac ggt atc gcc gct acg cac tta ctc gct ggt cta tca        480
Cys Met Ala Asp Gly Ile Ala Ala Thr His Leu Leu Ala Gly Leu Ser           
145                 150                 155                 160           

gat gaa tcc atg tct gac tct ttt gct tct aat atc cac act act atg        528
Asp Glu Ser Met Ser Asp Ser Phe Ala Ser Asn Ile His Thr Thr Met           
                165                 170                 175               

cag tct caa agt gcg tca gtt aga aga ggt gga ttc aga gtc aac cct        576
Gln Ser Gln Ser Ala Ser Val Arg Arg Gly Gly Phe Arg Val Asn Pro           
            180                 185                 190                   

tct gaa gca tta aca gca tct aca gca gtt atg gca gga ata gtt aga        624
Ser Glu Ala Leu Thr Ala Ser Thr Ala Val Met Ala Gly Ile Val Arg           
        195                 200                 205                       

gct gca aaa ggt gcc tcc gaa att gcc gct ggc gtt cta tcc cca gcc        672
Ala Ala Lys Gly Ala Ser Glu Ile Ala Ala Gly Val Leu Ser Pro Ala           
    210                 215                 220                           

gcc tca agc ctc aac gga cct ata tct gac ttg aga aga tac tca gct        720
Ala Ser Ser Leu Asn Gly Pro Ile Ser Asp Leu Arg Arg Tyr Ser Ala           
225                 230                 235                 240           

gct aag gtc cct ttg gct gat gta gaa caa gtc tgt cgt aag ttt gat        768
Ala Lys Val Pro Leu Ala Asp Val Glu Gln Val Cys Arg Lys Phe Asp           
                245                 250                 255               

gtg aca att aac gat gtt gct ttg gca gct att act gaa agc tac aga        816
Val Thr Ile Asn Asp Val Ala Leu Ala Ala Ile Thr Glu Ser Tyr Arg           
            260                 265                 270                   

aac gtc cta atc caa agg gga gaa aga cct aga ttt gat tct ctc aga        864
Asn Val Leu Ile Gln Arg Gly Glu Arg Pro Arg Phe Asp Ser Leu Arg           
        275                 280                 285                       

aca tta gta cca gta agt acc aga tca aat tca gct cta tct aag acc        912
Thr Leu Val Pro Val Ser Thr Arg Ser Asn Ser Ala Leu Ser Lys Thr           
    290                 295                 300                           

gac aat aga gtg tcc cta atg ctt cct aat ctt cca gtc gac cag gag        960
Asp Asn Arg Val Ser Leu Met Leu Pro Asn Leu Pro Val Asp Gln Glu           
305                 310                 315                 320           

aat cca ctg caa aga ctt aga atc gtg cat tct cgt ttg aca aga gcc       1008
Asn Pro Leu Gln Arg Leu Arg Ile Val His Ser Arg Leu Thr Arg Ala           
                325                 330                 335               

aaa gcg gga ggt caa cga caa ttt ggt aat act tta atg gca ata gcc       1056
Lys Ala Gly Gly Gln Arg Gln Phe Gly Asn Thr Leu Met Ala Ile Ala           
            340                 345                 350                   

aat aga ttg cca ttt cca atg acg gca tgg gca gtt ggg tta ttg atg       1104
Asn Arg Leu Pro Phe Pro Met Thr Ala Trp Ala Val Gly Leu Leu Met           
        355                 360                 365                       

aga ttg cct caa agg ggc gtt gtg act gtt gca aca aac gtg cca ggg       1152
Arg Leu Pro Gln Arg Gly Val Val Thr Val Ala Thr Asn Val Pro Gly           
    370                 375                 380                           

cca cgc aga cca cta caa atc atg ggt aga aga gtc ttg gat ctt tat       1200
Pro Arg Arg Pro Leu Gln Ile Met Gly Arg Arg Val Leu Asp Leu Tyr           
385                 390                 395                 400           

cct gtt tct ccc att gcc atg cag ctc cgt aca tcg gtt gct atg ctt       1248
Pro Val Ser Pro Ile Ala Met Gln Leu Arg Thr Ser Val Ala Met Leu           
                405                 410                 415               

tca tat gct gat gac tta tac ttc ggc att ctg gct gat tac gat gtt       1296
Ser Tyr Ala Asp Asp Leu Tyr Phe Gly Ile Leu Ala Asp Tyr Asp Val           
            420                 425                 430                   

gtt gct gat gcg ggc caa tta gct aga ggt atc gag gac gct gta gca       1344
Val Ala Asp Ala Gly Gln Leu Ala Arg Gly Ile Glu Asp Ala Val Ala           
        435                 440                 445                       

aga ttg gtg gct atc tcc aag aga agg aaa gtt act aga cgt cga ggt       1392
Arg Leu Val Ala Ile Ser Lys Arg Arg Lys Val Thr Arg Arg Arg Gly           
    450                 455                 460                           

gcc ctg tct tta gtc gtc cat cac cat cat cat cat taa                   1431
Ala Leu Ser Leu Val Val His His His His His His                           
465                 470                 475                               


<210>  27
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  27

Met Ala Asp Glu Ala Pro Thr Ser Asn His Leu Thr Thr Leu Asp Ala 
1               5                   10                  15      


Gly Phe Leu Lys Ala Glu Asp Val Asp Arg His Val Ser Leu Ala Ile 
            20                  25                  30          


Gly Ala Leu Ala Val Ile Glu Gly Pro Ala Pro Asp Gln Glu Ala Phe 
        35                  40                  45              


Leu Ser Ser Leu Ala Gln Arg Leu Arg Pro Cys Thr Arg Phe Gly Gln 
    50                  55                  60                  


Arg Leu Arg Leu Arg Pro Phe Asp Leu Gly Ala Pro Lys Trp Val Asp 
65                  70                  75                  80  


Asp Pro Asp Phe Asp Leu Gly Arg His Val Trp Arg Ile Ala Leu Pro 
                85                  90                  95      


Arg Pro Gly Asn Glu Asp Gln Leu Phe Glu Leu Ile Ala Asp Leu Met 
            100                 105                 110         


Ala Arg Arg Leu Asp Arg Gly Arg Pro Leu Trp Glu Val Trp Val Ile 
        115                 120                 125             


Glu Gly Leu Ala Asp Ser Lys Trp Ala Ile Leu Thr Lys Leu His His 
    130                 135                 140                 


Cys Met Ala Asp Gly Ile Ala Ala Thr His Leu Leu Ala Gly Leu Ser 
145                 150                 155                 160 


Asp Glu Ser Met Ser Asp Ser Phe Ala Ser Asn Ile His Thr Thr Met 
                165                 170                 175     


Gln Ser Gln Ser Ala Ser Val Arg Arg Gly Gly Phe Arg Val Asn Pro 
            180                 185                 190         


Ser Glu Ala Leu Thr Ala Ser Thr Ala Val Met Ala Gly Ile Val Arg 
        195                 200                 205             


Ala Ala Lys Gly Ala Ser Glu Ile Ala Ala Gly Val Leu Ser Pro Ala 
    210                 215                 220                 


Ala Ser Ser Leu Asn Gly Pro Ile Ser Asp Leu Arg Arg Tyr Ser Ala 
225                 230                 235                 240 


Ala Lys Val Pro Leu Ala Asp Val Glu Gln Val Cys Arg Lys Phe Asp 
                245                 250                 255     


Val Thr Ile Asn Asp Val Ala Leu Ala Ala Ile Thr Glu Ser Tyr Arg 
            260                 265                 270         


Asn Val Leu Ile Gln Arg Gly Glu Arg Pro Arg Phe Asp Ser Leu Arg 
        275                 280                 285             


Thr Leu Val Pro Val Ser Thr Arg Ser Asn Ser Ala Leu Ser Lys Thr 
    290                 295                 300                 


Asp Asn Arg Val Ser Leu Met Leu Pro Asn Leu Pro Val Asp Gln Glu 
305                 310                 315                 320 


Asn Pro Leu Gln Arg Leu Arg Ile Val His Ser Arg Leu Thr Arg Ala 
                325                 330                 335     


Lys Ala Gly Gly Gln Arg Gln Phe Gly Asn Thr Leu Met Ala Ile Ala 
            340                 345                 350         


Asn Arg Leu Pro Phe Pro Met Thr Ala Trp Ala Val Gly Leu Leu Met 
        355                 360                 365             


Arg Leu Pro Gln Arg Gly Val Val Thr Val Ala Thr Asn Val Pro Gly 
    370                 375                 380                 


Pro Arg Arg Pro Leu Gln Ile Met Gly Arg Arg Val Leu Asp Leu Tyr 
385                 390                 395                 400 


Pro Val Ser Pro Ile Ala Met Gln Leu Arg Thr Ser Val Ala Met Leu 
                405                 410                 415     


Ser Tyr Ala Asp Asp Leu Tyr Phe Gly Ile Leu Ala Asp Tyr Asp Val 
            420                 425                 430         


Val Ala Asp Ala Gly Gln Leu Ala Arg Gly Ile Glu Asp Ala Val Ala 
        435                 440                 445             


Arg Leu Val Ala Ile Ser Lys Arg Arg Lys Val Thr Arg Arg Arg Gly 
    450                 455                 460                 


Ala Leu Ser Leu Val Val His His His His His His 
465                 470                 475     


<210>  28
<211>  181
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  28

Met Thr Glu Tyr Glu Gly Pro Lys Thr Lys Phe His Ala Leu Met Gln 
1               5                   10                  15      


Glu Gln Ile His Asn Glu Phe Thr Ala Ala Gln Gln Tyr Val Ala Ile 
            20                  25                  30          


Ala Val Tyr Phe Asp Ser Glu Asp Leu Pro Gln Leu Ala Lys His Phe 
        35                  40                  45              


Tyr Ser Gln Ala Val Glu Glu Arg Asn His Ala Met Met Leu Val Gln 
    50                  55                  60                  


His Leu Leu Asp Arg Asp Leu Arg Val Glu Ile Pro Gly Val Asp Thr 
65                  70                  75                  80  


Val Arg Asn Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala Leu Ala Leu 
                85                  90                  95      


Asp Gln Glu Arg Thr Val Thr Asp Gln Val Gly Arg Leu Thr Ala Val 
            100                 105                 110         


Ala Arg Asp Glu Gly Asp Phe Leu Gly Glu Gln Phe Met Gln Trp Phe 
        115                 120                 125             


Leu Gln Glu Gln Ile Glu Glu Val Ala Leu Met Ala Thr Leu Val Arg 
    130                 135                 140                 


Val Ala Asp Arg Ala Gly Ala Asn Leu Phe Glu Leu Glu Asn Phe Val 
145                 150                 155                 160 


Ala Arg Glu Val Asp Val Ala Pro Ala Ala Ser Gly Ala Pro His Ala 
                165                 170                 175     


Ala Gly Gly Arg Leu 
            180     


<210>  29
<211>  570
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(570)

<400>  29
atg gcc gac gag gca cca act agt aca gaa tac gaa gga cca aaa aca         48
Met Ala Asp Glu Ala Pro Thr Ser Thr Glu Tyr Glu Gly Pro Lys Thr           
1               5                   10                  15                

aag ttt cat gct tta atg caa gag caa att cat aac gaa ttt aca gcg         96
Lys Phe His Ala Leu Met Gln Glu Gln Ile His Asn Glu Phe Thr Ala           
            20                  25                  30                    

gct cag caa tac gtg gct atc gcc gta tac ttt gat tct gaa gat ctt        144
Ala Gln Gln Tyr Val Ala Ile Ala Val Tyr Phe Asp Ser Glu Asp Leu           
        35                  40                  45                        

cct caa ctg gcc aaa cac ttc tat tcc caa gca gta gaa gct atg atg        192
Pro Gln Leu Ala Lys His Phe Tyr Ser Gln Ala Val Glu Ala Met Met           
    50                  55                  60                            

ctt gtc caa cat ttg ctg gac aga gat ttg cga gta gaa atc cct ggt        240
Leu Val Gln His Leu Leu Asp Arg Asp Leu Arg Val Glu Ile Pro Gly           
65                  70                  75                  80            

gtt gat act gtc aga aat caa ttt gat aga cca aga gaa gca tta gca        288
Val Asp Thr Val Arg Asn Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala           
                85                  90                  95                

ttg gct cta gat cag gaa agg acg gtt aca gac caa gtt ggg aga ttg        336
Leu Ala Leu Asp Gln Glu Arg Thr Val Thr Asp Gln Val Gly Arg Leu           
            100                 105                 110                   

acc gcc gtt gct aga gat gaa gga gat ttc tta ggt gaa caa ttc atg        384
Thr Ala Val Ala Arg Asp Glu Gly Asp Phe Leu Gly Glu Gln Phe Met           
        115                 120                 125                       

caa tgg ttt ttg caa gag cag ata gag gaa gtc gcc ctt atg gct act        432
Gln Trp Phe Leu Gln Glu Gln Ile Glu Glu Val Ala Leu Met Ala Thr           
    130                 135                 140                           

ctc gtt aga gtg gct gac cgt gct ggt gcg aat cta ttt gaa tta gag        480
Leu Val Arg Val Ala Asp Arg Ala Gly Ala Asn Leu Phe Glu Leu Glu           
145                 150                 155                 160           

aac ttc gtg gct aga gaa gtc gac gtt gca cca gcc gca tca ggc gca        528
Asn Phe Val Ala Arg Glu Val Asp Val Ala Pro Ala Ala Ser Gly Ala           
                165                 170                 175               

cct cat gct gca ggc ggt aga cac cat cat cat cac cac taa                570
Pro His Ala Ala Gly Gly Arg His His His His His His                       
            180                 185                                       


<210>  30
<211>  189
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Met Ala Asp Glu Ala Pro Thr Ser Thr Glu Tyr Glu Gly Pro Lys Thr 
1               5                   10                  15      


Lys Phe His Ala Leu Met Gln Glu Gln Ile His Asn Glu Phe Thr Ala 
            20                  25                  30          


Ala Gln Gln Tyr Val Ala Ile Ala Val Tyr Phe Asp Ser Glu Asp Leu 
        35                  40                  45              


Pro Gln Leu Ala Lys His Phe Tyr Ser Gln Ala Val Glu Ala Met Met 
    50                  55                  60                  


Leu Val Gln His Leu Leu Asp Arg Asp Leu Arg Val Glu Ile Pro Gly 
65                  70                  75                  80  


Val Asp Thr Val Arg Asn Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala 
                85                  90                  95      


Leu Ala Leu Asp Gln Glu Arg Thr Val Thr Asp Gln Val Gly Arg Leu 
            100                 105                 110         


Thr Ala Val Ala Arg Asp Glu Gly Asp Phe Leu Gly Glu Gln Phe Met 
        115                 120                 125             


Gln Trp Phe Leu Gln Glu Gln Ile Glu Glu Val Ala Leu Met Ala Thr 
    130                 135                 140                 


Leu Val Arg Val Ala Asp Arg Ala Gly Ala Asn Leu Phe Glu Leu Glu 
145                 150                 155                 160 


Asn Phe Val Ala Arg Glu Val Asp Val Ala Pro Ala Ala Ser Gly Ala 
                165                 170                 175     


Pro His Ala Ala Gly Gly Arg His His His His His His 
            180                 185                 


<210>  31
<211>  1060
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  31

Cys Gly Asp Gln Ser Asp His Val Leu Gln His Trp Thr Val Asp Ile 
1               5                   10                  15      


Ser Ile Asp Glu His Glu Gly Leu Thr Arg Ala Lys Ala Arg Leu Arg 
            20                  25                  30          


Trp Arg Glu Lys Glu Leu Val Gly Val Gly Leu Ala Arg Leu Asn Pro 
        35                  40                  45              


Ala Asp Arg Asn Val Pro Glu Ile Gly Asp Glu Leu Ser Val Ala Arg 
    50                  55                  60                  


Ala Leu Ser Asp Leu Gly Lys Arg Met Leu Lys Val Ser Thr His Asp 
65                  70                  75                  80  


Ile Glu Ala Val Thr His Gln Pro Ala Arg Leu Leu Tyr Pro Asp Thr 
                85                  90                  95      


Met Val Thr Thr Asp Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg 
            100                 105                 110         


Ala Pro Ser Leu His Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp 
        115                 120                 125             


His Thr Val Ala Leu Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr 
    130                 135                 140                 


Asp His Ser Gly Arg Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp 
145                 150                 155                 160 


His Phe Arg Val Ala Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu 
                165                 170                 175     


Arg Phe Pro Asn Pro Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe 
            180                 185                 190         


Ser Pro Ala Asp Phe Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala 
        195                 200                 205             


Ile Leu Leu Arg Arg Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp 
    210                 215                 220                 


Trp Asp Leu Val Glu Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr 
225                 230                 235                 240 


Val Arg Ile Asp Val Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala 
                245                 250                 255     


Ala Ser Lys Leu Thr Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His 
            260                 265                 270         


Ala Glu Leu Phe Trp Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile 
        275                 280                 285             


Pro His Ser Ser Leu Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe 
    290                 295                 300                 


Gly Arg Asp Phe Pro Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe 
305                 310                 315                 320 


Gly His Asp Arg Ser Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu 
                325                 330                 335     


Arg Ala Ser Leu Leu Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu 
            340                 345                 350         


Asp Ala Thr Met Ala Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr 
        355                 360                 365             


Glu Leu His Ala Ser Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro 
    370                 375                 380                 


Ala Thr Pro Gln Ala Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu 
385                 390                 395                 400 


Glu Pro Pro Pro Ala Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His 
                405                 410                 415     


Val Arg Ala Lys Asp His Arg Asn His Leu Thr Thr Leu Asp Ala Gly 
            420                 425                 430         


Phe Leu Lys Ala Glu Asp Val Asp Arg His Val Ser Leu Ala Ile Gly 
        435                 440                 445             


Ala Leu Ala Val Ile Glu Gly Pro Ala Pro Asp Gln Glu Ala Phe Leu 
    450                 455                 460                 


Ser Ser Leu Ala Gln Arg Leu Arg Pro Cys Thr Arg Phe Gly Gln Arg 
465                 470                 475                 480 


Leu Arg Leu Arg Pro Phe Asp Leu Gly Ala Pro Lys Trp Val Asp Asp 
                485                 490                 495     


Pro Asp Phe Asp Leu Gly Arg His Val Trp Arg Ile Ala Leu Pro Arg 
            500                 505                 510         


Pro Gly Asn Glu Asp Gln Leu Phe Glu Leu Ile Ala Asp Leu Met Ala 
        515                 520                 525             


Arg Arg Leu Asp Arg Gly Arg Pro Leu Trp Glu Val Trp Val Ile Glu 
    530                 535                 540                 


Gly Leu Ala Asp Ser Lys Trp Ala Ile Leu Thr Lys Leu His His Cys 
545                 550                 555                 560 


Met Ala Asp Gly Ile Ala Ala Thr His Leu Leu Ala Gly Leu Ser Asp 
                565                 570                 575     


Glu Ser Met Ser Asp Ser Phe Ala Ser Asn Ile His Thr Thr Met Gln 
            580                 585                 590         


Ser Gln Ser Ala Ser Val Arg Arg Gly Gly Phe Arg Val Asn Pro Ser 
        595                 600                 605             


Glu Ala Leu Thr Ala Ser Thr Ala Val Met Ala Gly Ile Val Arg Ala 
    610                 615                 620                 


Ala Lys Gly Ala Ser Glu Ile Ala Ala Gly Val Leu Ser Pro Ala Ala 
625                 630                 635                 640 


Ser Ser Leu Asn Gly Pro Ile Ser Asp Leu Arg Arg Tyr Ser Ala Ala 
                645                 650                 655     


Lys Val Pro Leu Ala Asp Val Glu Gln Val Cys Arg Lys Phe Asp Val 
            660                 665                 670         


Thr Ile Asn Asp Val Ala Leu Ala Ala Ile Thr Glu Ser Tyr Arg Asn 
        675                 680                 685             


Val Leu Ile Gln Arg Gly Glu Arg Pro Arg Phe Asp Ser Leu Arg Thr 
    690                 695                 700                 


Leu Val Pro Val Ser Thr Arg Ser Asn Ser Ala Leu Ser Lys Thr Asp 
705                 710                 715                 720 


Asn Arg Val Ser Leu Met Leu Pro Asn Leu Pro Val Asp Gln Glu Asn 
                725                 730                 735     


Pro Leu Gln Arg Leu Arg Ile Val His Ser Arg Leu Thr Arg Ala Lys 
            740                 745                 750         


Ala Gly Gly Gln Arg Gln Phe Gly Asn Thr Leu Met Ala Ile Ala Asn 
        755                 760                 765             


Arg Leu Pro Phe Pro Met Thr Ala Trp Ala Val Gly Leu Leu Met Arg 
    770                 775                 780                 


Leu Pro Gln Arg Gly Val Val Thr Val Ala Thr Asn Val Pro Gly Pro 
785                 790                 795                 800 


Arg Arg Pro Leu Gln Ile Met Gly Arg Arg Val Leu Asp Leu Tyr Pro 
                805                 810                 815     


Val Ser Pro Ile Ala Met Gln Leu Arg Thr Ser Val Ala Met Leu Ser 
            820                 825                 830         


Tyr Ala Asp Asp Leu Tyr Phe Gly Ile Leu Ala Asp Tyr Asp Val Val 
        835                 840                 845             


Ala Asp Ala Gly Gln Leu Ala Arg Gly Ile Glu Asp Ala Val Ala Arg 
    850                 855                 860                 


Leu Val Ala Ile Ser Lys Arg Arg Lys Val Thr Arg Arg Arg Gly Ala 
865                 870                 875                 880 


Leu Ser Leu Val Val Thr Glu Tyr Glu Gly Pro Lys Thr Lys Phe His 
                885                 890                 895     


Ala Leu Met Gln Glu Gln Ile His Asn Glu Phe Thr Ala Ala Gln Gln 
            900                 905                 910         


Tyr Val Ala Ile Ala Val Tyr Phe Asp Ser Glu Asp Leu Pro Gln Leu 
        915                 920                 925             


Ala Lys His Phe Tyr Ser Gln Ala Val Glu Ala Met Met Leu Val Gln 
    930                 935                 940                 


His Leu Leu Asp Arg Asp Leu Arg Val Glu Ile Pro Gly Val Asp Thr 
945                 950                 955                 960 


Val Arg Asn Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala Leu Ala Leu 
                965                 970                 975     


Asp Gln Glu Arg Thr Val Thr Asp Gln Val Gly Arg Leu Thr Ala Val 
            980                 985                 990         


Ala Arg Asp Glu Gly Asp Phe Leu  Gly Glu Gln Phe Met  Gln Trp Phe 
        995                 1000                 1005             


Leu Gln  Glu Gln Ile Glu Glu  Val Ala Leu Met Ala  Thr Leu Val 
    1010                 1015                 1020             


Arg Val  Ala Asp Arg Ala Gly  Ala Asn Leu Phe Glu  Leu Glu Asn 
    1025                 1030                 1035             


Phe Val  Ala Arg Glu Val Asp  Val Ala Pro Ala Ala  Ser Gly Ala 
    1040                 1045                 1050             


Pro His  Ala Ala Gly Gly Arg  
    1055                 1060 


<210>  32
<211>  3225
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(3225)

<400>  32
atg gcc gac gag gca cca act agt tgc ggc gac cag tca gat cac gtt         48
Met Ala Asp Glu Ala Pro Thr Ser Cys Gly Asp Gln Ser Asp His Val           
1               5                   10                  15                

ctg caa cat tgg aca gtc gat atc tca att gat gaa cat gaa ggt ttg         96
Leu Gln His Trp Thr Val Asp Ile Ser Ile Asp Glu His Glu Gly Leu           
            20                  25                  30                    

act aga gct aaa gct aga ctt cga tgg aga gag aag gaa ttg gtt ggt        144
Thr Arg Ala Lys Ala Arg Leu Arg Trp Arg Glu Lys Glu Leu Val Gly           
        35                  40                  45                        

gtg ggt ttg gct agg ctt aat cct gct gac aga aac gta cca gaa att        192
Val Gly Leu Ala Arg Leu Asn Pro Ala Asp Arg Asn Val Pro Glu Ile           
    50                  55                  60                            

ggg gat gaa ttg tcc gtc gcc aga gcc ttg agt gat ctc gga aag agg        240
Gly Asp Glu Leu Ser Val Ala Arg Ala Leu Ser Asp Leu Gly Lys Arg           
65                  70                  75                  80            

atg ttg aaa gtg tcg act cac gac atc gag gca gtg act cat caa cca        288
Met Leu Lys Val Ser Thr His Asp Ile Glu Ala Val Thr His Gln Pro           
                85                  90                  95                

gca agg ctc ctt tat cct gat aca atg gta aca act gac gtt atc aaa        336
Ala Arg Leu Leu Tyr Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys           
            100                 105                 110                   

tct aga gta caa ttg gct tgc aga gcc cca tca tta cat aat tcc caa        384
Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln           
        115                 120                 125                       

cca tgg cgc tgg att gcc gag gat cac aca gtg gca cta ttc tta gac        432
Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp           
    130                 135                 140                           

aaa gat aga gtt ctt tat gct aca gat cat agt ggc aga gaa gca ctg        480
Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu           
145                 150                 155                 160           

ctg gga tgt ggt gct gtc cta gac cac ttc aga gtt gct atg gct gcg        528
Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala Met Ala Ala           
                165                 170                 175               

gcg ggc acc aca gca aat gtc gaa cga ttc cca aat cct aac gat cca        576
Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro           
            180                 185                 190                   

tta cat ctt gca tct att gac ttt tct cct gct gat ttt gtc aca gaa        624
Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu           
        195                 200                 205                       

ggc cac aga ttg aga gct gat gcg atc tta ttg agg aga aca gat aga        672
Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg           
    210                 215                 220                           

ttg cct ttc gct gag cct cca gac tgg gac tta gta gaa tca cag ttg        720
Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu           
225                 230                 235                 240           

agg act aca gtt act gct gat acc gtt aga atc gat gtt ata gcg gat        768
Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp           
                245                 250                 255               

gat atg agg cca gaa ctt gca gcc gca tcc aaa ttg acc gaa tct ttg        816
Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu           
            260                 265                 270                   

aga cta tac gat agc tct tac cat gcg gaa ctg ttt tgg tgg act ggt        864
Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly           
        275                 280                 285                       

gct ttc gaa aca tct gaa ggg ata cca cat tct tca tta gtt tca gct        912
Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala           
    290                 295                 300                           

gca gaa tcc gat aga gtc act ttt ggt cgt gat ttc cca gtc gta gca        960
Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala           
305                 310                 315                 320           

aat act gac aga cga cct gaa ttt ggt cat gac aga tct aaa gta ctt       1008
Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu           
                325                 330                 335               

gtt ctc agc acc tac gat aat gaa agg gct tct ttg tta aga tgc ggt       1056
Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly           
            340                 345                 350                   

gaa atg cta agt gcc gtc tta ctg gat gcg act atg gct gga ttg gca       1104
Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala           
        355                 360                 365                       

act tgt aca ctg acc cat atc acg gaa ctg cat gca tca aga gat ctc       1152
Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser Arg Asp Leu           
    370                 375                 380                           

gta gca gcc ttg att ggc caa cca gcc aca cct caa gcc ctt gtg aga       1200
Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg           
385                 390                 395                 400           

gta gga ttg gct cca gag atg gag gaa cca cct cct gct act cca cgt       1248
Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg           
                405                 410                 415               

aga ccc atc gac gaa gtg ttc cat gtg aga gct aag gat cat aga aat       1296
Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp His Arg Asn           
            420                 425                 430                   

cac ctt act aca ctc gac gcc gga ttc ctt aaa gca gaa gat gta gat       1344
His Leu Thr Thr Leu Asp Ala Gly Phe Leu Lys Ala Glu Asp Val Asp           
        435                 440                 445                       

aga cat gtg agt cta gca atc ggc gct ttg gcc gta att gaa ggc cca       1392
Arg His Val Ser Leu Ala Ile Gly Ala Leu Ala Val Ile Glu Gly Pro           
    450                 455                 460                           

gca cca gac cag gaa gct ttt cta tct agt ctt gct cag agg tta aga       1440
Ala Pro Asp Gln Glu Ala Phe Leu Ser Ser Leu Ala Gln Arg Leu Arg           
465                 470                 475                 480           

cca tgt acg cgt ttc ggt caa aga tta aga cta aga cca ttc gat ctt       1488
Pro Cys Thr Arg Phe Gly Gln Arg Leu Arg Leu Arg Pro Phe Asp Leu           
                485                 490                 495               

ggc gca cca aag tgg gtg gat gat cct gat ttt gac ctt ggc aga cat       1536
Gly Ala Pro Lys Trp Val Asp Asp Pro Asp Phe Asp Leu Gly Arg His           
            500                 505                 510                   

gtt tgg aga ata gca tta cct aga cct gga aat gag gat caa tta ttt       1584
Val Trp Arg Ile Ala Leu Pro Arg Pro Gly Asn Glu Asp Gln Leu Phe           
        515                 520                 525                       

gaa tta atc gcg gac ttg atg gct aga agg ttg gat aga ggt aga cca       1632
Glu Leu Ile Ala Asp Leu Met Ala Arg Arg Leu Asp Arg Gly Arg Pro           
    530                 535                 540                           

cta tgg gag gtt tgg gtt att gaa ggg ctt gcg gat tcc aaa tgg gcc       1680
Leu Trp Glu Val Trp Val Ile Glu Gly Leu Ala Asp Ser Lys Trp Ala           
545                 550                 555                 560           

ata ctg aca aag ctg cat cac tgt atg gcc gat ggg atc gct gca aca       1728
Ile Leu Thr Lys Leu His His Cys Met Ala Asp Gly Ile Ala Ala Thr           
                565                 570                 575               

cac ttg tta gcc gga ttg tct gac gag tcg atg tca gat tct ttt gca       1776
His Leu Leu Ala Gly Leu Ser Asp Glu Ser Met Ser Asp Ser Phe Ala           
            580                 585                 590                   

tct aac atc cat acg aca atg caa tca caa tct gca tct gtc aga cga       1824
Ser Asn Ile His Thr Thr Met Gln Ser Gln Ser Ala Ser Val Arg Arg           
        595                 600                 605                       

gga ggt ttc aga gtt aat cca tct gag gcg cta acc gct tct aca gcg       1872
Gly Gly Phe Arg Val Asn Pro Ser Glu Ala Leu Thr Ala Ser Thr Ala           
    610                 615                 620                           

gtc atg gcc gga atc gta aga gct gct aag ggt gca agt gag att gct       1920
Val Met Ala Gly Ile Val Arg Ala Ala Lys Gly Ala Ser Glu Ile Ala           
625                 630                 635                 640           

gcc ggt gtt cta tct cca gcg gct tca tca ttg aac gga cca ata tcc       1968
Ala Gly Val Leu Ser Pro Ala Ala Ser Ser Leu Asn Gly Pro Ile Ser           
                645                 650                 655               

gac ctc aga aga tac tct gca gct aaa gtt cca ctc gcc gat gtt gaa       2016
Asp Leu Arg Arg Tyr Ser Ala Ala Lys Val Pro Leu Ala Asp Val Glu           
            660                 665                 670                   

caa gtt tgt aga aaa ttt gat gtc acc atc aat gac gta gct cta gct       2064
Gln Val Cys Arg Lys Phe Asp Val Thr Ile Asn Asp Val Ala Leu Ala           
        675                 680                 685                       

gcc att aca gaa tct tac aga aat gtt ctt ata caa aga ggt gaa aga       2112
Ala Ile Thr Glu Ser Tyr Arg Asn Val Leu Ile Gln Arg Gly Glu Arg           
    690                 695                 700                           

cct aga ttc gat tct ttg cgt aca ttg gtt cca gtg agc acc aga tct       2160
Pro Arg Phe Asp Ser Leu Arg Thr Leu Val Pro Val Ser Thr Arg Ser           
705                 710                 715                 720           

aat agc gct cta tct aag aca gat aac aga gtc agt cta atg ctg ccc       2208
Asn Ser Ala Leu Ser Lys Thr Asp Asn Arg Val Ser Leu Met Leu Pro           
                725                 730                 735               

aat ttg cca gtg gat cag gaa aac cct ctg caa cga ttg aga att gta       2256
Asn Leu Pro Val Asp Gln Glu Asn Pro Leu Gln Arg Leu Arg Ile Val           
            740                 745                 750                   

cat tcc cgt tta act aga gcg aaa gct ggg ggt caa aga caa ttt ggt       2304
His Ser Arg Leu Thr Arg Ala Lys Ala Gly Gly Gln Arg Gln Phe Gly           
        755                 760                 765                       

aat acc tta atg gca att gct aac aga cta cca ttc cca atg act gct       2352
Asn Thr Leu Met Ala Ile Ala Asn Arg Leu Pro Phe Pro Met Thr Ala           
    770                 775                 780                           

tgg gca gtt ggt tta cta atg cgt tta cca caa aga ggc gta gtc aca       2400
Trp Ala Val Gly Leu Leu Met Arg Leu Pro Gln Arg Gly Val Val Thr           
785                 790                 795                 800           

gtc gct act aat gtt cct ggg ccg cgt aga cct ctg caa atc atg ggt       2448
Val Ala Thr Asn Val Pro Gly Pro Arg Arg Pro Leu Gln Ile Met Gly           
                805                 810                 815               

aga agg gtt tta gac ttg tac cct gtt tct cct att gct atg caa ctg       2496
Arg Arg Val Leu Asp Leu Tyr Pro Val Ser Pro Ile Ala Met Gln Leu           
            820                 825                 830                   

aga aca tca gtc gca atg ctt tcc tac gct gat gac ttg tat ttt ggt       2544
Arg Thr Ser Val Ala Met Leu Ser Tyr Ala Asp Asp Leu Tyr Phe Gly           
        835                 840                 845                       

atc ttg gcc gat tac gat gta gtt gcc gac gcc ggg caa ctg gct aga       2592
Ile Leu Ala Asp Tyr Asp Val Val Ala Asp Ala Gly Gln Leu Ala Arg           
    850                 855                 860                           

ggt att gag gat gca gtc gca aga ttg gta gcc atc tca aaa aga cgc       2640
Gly Ile Glu Asp Ala Val Ala Arg Leu Val Ala Ile Ser Lys Arg Arg           
865                 870                 875                 880           

aaa gtg acg cgt aga aga ggc gct ttg tca tta gta gtt aca gaa tac       2688
Lys Val Thr Arg Arg Arg Gly Ala Leu Ser Leu Val Val Thr Glu Tyr           
                885                 890                 895               

gaa gga cca aag aca aag ttt cac gct ctt atg caa gag caa atc cac       2736
Glu Gly Pro Lys Thr Lys Phe His Ala Leu Met Gln Glu Gln Ile His           
            900                 905                 910                   

aac gaa ttt act gct gct cag caa tac gtt gca ata gcc gta tac ttt       2784
Asn Glu Phe Thr Ala Ala Gln Gln Tyr Val Ala Ile Ala Val Tyr Phe           
        915                 920                 925                       

gat tca gaa gat ttg cca caa ttg gca aaa cat ttc tat tcc caa gcc       2832
Asp Ser Glu Asp Leu Pro Gln Leu Ala Lys His Phe Tyr Ser Gln Ala           
    930                 935                 940                           

gtg gag gcc atg atg tta gtt caa cac ctc cta gac aga gat ttg aga       2880
Val Glu Ala Met Met Leu Val Gln His Leu Leu Asp Arg Asp Leu Arg           
945                 950                 955                 960           

gtt gaa att cca ggt gtt gat aca gtc aga aac caa ttt gat aga cct       2928
Val Glu Ile Pro Gly Val Asp Thr Val Arg Asn Gln Phe Asp Arg Pro           
                965                 970                 975               

cgt gaa gca ttg gct cta gca tta gat cag gag aga act gtg acg gat       2976
Arg Glu Ala Leu Ala Leu Ala Leu Asp Gln Glu Arg Thr Val Thr Asp           
            980                 985                 990                   

caa gtg ggt aga ttg aca gct gtt  gca cgt gac gaa gga  gac ttt ctt     3024
Gln Val Gly Arg Leu Thr Ala Val  Ala Arg Asp Glu Gly  Asp Phe Leu         
        995                 1000                 1005                     

ggg gag  cag ttt atg caa tgg  ttt ctc cag gaa caa  att gaa gag        3069
Gly Glu  Gln Phe Met Gln Trp  Phe Leu Gln Glu Gln  Ile Glu Glu            
    1010                 1015                 1020                        

gtt gca  cta atg gca act tta  gtg aga gtc gct gac  aga gct ggt        3114
Val Ala  Leu Met Ala Thr Leu  Val Arg Val Ala Asp  Arg Ala Gly            
    1025                 1030                 1035                        

gct aat  ctc ttc gaa tta gaa  aac ttt gta gcc aga  gag gtt gat        3159
Ala Asn  Leu Phe Glu Leu Glu  Asn Phe Val Ala Arg  Glu Val Asp            
    1040                 1045                 1050                        

gtt gca  cca gca gcc tca ggt  gcc cct cac gct gcc  ggg ggc aga        3204
Val Ala  Pro Ala Ala Ser Gly  Ala Pro His Ala Ala  Gly Gly Arg            
    1055                 1060                 1065                        

cat cat  cac cat cac cat taa                                          3225
His His  His His His His                                                  
    1070                                                                  


<210>  33
<211>  1074
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  33

Met Ala Asp Glu Ala Pro Thr Ser Cys Gly Asp Gln Ser Asp His Val 
1               5                   10                  15      


Leu Gln His Trp Thr Val Asp Ile Ser Ile Asp Glu His Glu Gly Leu 
            20                  25                  30          


Thr Arg Ala Lys Ala Arg Leu Arg Trp Arg Glu Lys Glu Leu Val Gly 
        35                  40                  45              


Val Gly Leu Ala Arg Leu Asn Pro Ala Asp Arg Asn Val Pro Glu Ile 
    50                  55                  60                  


Gly Asp Glu Leu Ser Val Ala Arg Ala Leu Ser Asp Leu Gly Lys Arg 
65                  70                  75                  80  


Met Leu Lys Val Ser Thr His Asp Ile Glu Ala Val Thr His Gln Pro 
                85                  90                  95      


Ala Arg Leu Leu Tyr Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys 
            100                 105                 110         


Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln 
        115                 120                 125             


Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp 
    130                 135                 140                 


Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu 
145                 150                 155                 160 


Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala Met Ala Ala 
                165                 170                 175     


Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro 
            180                 185                 190         


Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu 
        195                 200                 205             


Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg 
    210                 215                 220                 


Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu 
225                 230                 235                 240 


Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp 
                245                 250                 255     


Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu 
            260                 265                 270         


Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly 
        275                 280                 285             


Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala 
    290                 295                 300                 


Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala 
305                 310                 315                 320 


Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu 
                325                 330                 335     


Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly 
            340                 345                 350         


Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala 
        355                 360                 365             


Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser Arg Asp Leu 
    370                 375                 380                 


Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg 
385                 390                 395                 400 


Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg 
                405                 410                 415     


Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp His Arg Asn 
            420                 425                 430         


His Leu Thr Thr Leu Asp Ala Gly Phe Leu Lys Ala Glu Asp Val Asp 
        435                 440                 445             


Arg His Val Ser Leu Ala Ile Gly Ala Leu Ala Val Ile Glu Gly Pro 
    450                 455                 460                 


Ala Pro Asp Gln Glu Ala Phe Leu Ser Ser Leu Ala Gln Arg Leu Arg 
465                 470                 475                 480 


Pro Cys Thr Arg Phe Gly Gln Arg Leu Arg Leu Arg Pro Phe Asp Leu 
                485                 490                 495     


Gly Ala Pro Lys Trp Val Asp Asp Pro Asp Phe Asp Leu Gly Arg His 
            500                 505                 510         


Val Trp Arg Ile Ala Leu Pro Arg Pro Gly Asn Glu Asp Gln Leu Phe 
        515                 520                 525             


Glu Leu Ile Ala Asp Leu Met Ala Arg Arg Leu Asp Arg Gly Arg Pro 
    530                 535                 540                 


Leu Trp Glu Val Trp Val Ile Glu Gly Leu Ala Asp Ser Lys Trp Ala 
545                 550                 555                 560 


Ile Leu Thr Lys Leu His His Cys Met Ala Asp Gly Ile Ala Ala Thr 
                565                 570                 575     


His Leu Leu Ala Gly Leu Ser Asp Glu Ser Met Ser Asp Ser Phe Ala 
            580                 585                 590         


Ser Asn Ile His Thr Thr Met Gln Ser Gln Ser Ala Ser Val Arg Arg 
        595                 600                 605             


Gly Gly Phe Arg Val Asn Pro Ser Glu Ala Leu Thr Ala Ser Thr Ala 
    610                 615                 620                 


Val Met Ala Gly Ile Val Arg Ala Ala Lys Gly Ala Ser Glu Ile Ala 
625                 630                 635                 640 


Ala Gly Val Leu Ser Pro Ala Ala Ser Ser Leu Asn Gly Pro Ile Ser 
                645                 650                 655     


Asp Leu Arg Arg Tyr Ser Ala Ala Lys Val Pro Leu Ala Asp Val Glu 
            660                 665                 670         


Gln Val Cys Arg Lys Phe Asp Val Thr Ile Asn Asp Val Ala Leu Ala 
        675                 680                 685             


Ala Ile Thr Glu Ser Tyr Arg Asn Val Leu Ile Gln Arg Gly Glu Arg 
    690                 695                 700                 


Pro Arg Phe Asp Ser Leu Arg Thr Leu Val Pro Val Ser Thr Arg Ser 
705                 710                 715                 720 


Asn Ser Ala Leu Ser Lys Thr Asp Asn Arg Val Ser Leu Met Leu Pro 
                725                 730                 735     


Asn Leu Pro Val Asp Gln Glu Asn Pro Leu Gln Arg Leu Arg Ile Val 
            740                 745                 750         


His Ser Arg Leu Thr Arg Ala Lys Ala Gly Gly Gln Arg Gln Phe Gly 
        755                 760                 765             


Asn Thr Leu Met Ala Ile Ala Asn Arg Leu Pro Phe Pro Met Thr Ala 
    770                 775                 780                 


Trp Ala Val Gly Leu Leu Met Arg Leu Pro Gln Arg Gly Val Val Thr 
785                 790                 795                 800 


Val Ala Thr Asn Val Pro Gly Pro Arg Arg Pro Leu Gln Ile Met Gly 
                805                 810                 815     


Arg Arg Val Leu Asp Leu Tyr Pro Val Ser Pro Ile Ala Met Gln Leu 
            820                 825                 830         


Arg Thr Ser Val Ala Met Leu Ser Tyr Ala Asp Asp Leu Tyr Phe Gly 
        835                 840                 845             


Ile Leu Ala Asp Tyr Asp Val Val Ala Asp Ala Gly Gln Leu Ala Arg 
    850                 855                 860                 


Gly Ile Glu Asp Ala Val Ala Arg Leu Val Ala Ile Ser Lys Arg Arg 
865                 870                 875                 880 


Lys Val Thr Arg Arg Arg Gly Ala Leu Ser Leu Val Val Thr Glu Tyr 
                885                 890                 895     


Glu Gly Pro Lys Thr Lys Phe His Ala Leu Met Gln Glu Gln Ile His 
            900                 905                 910         


Asn Glu Phe Thr Ala Ala Gln Gln Tyr Val Ala Ile Ala Val Tyr Phe 
        915                 920                 925             


Asp Ser Glu Asp Leu Pro Gln Leu Ala Lys His Phe Tyr Ser Gln Ala 
    930                 935                 940                 


Val Glu Ala Met Met Leu Val Gln His Leu Leu Asp Arg Asp Leu Arg 
945                 950                 955                 960 


Val Glu Ile Pro Gly Val Asp Thr Val Arg Asn Gln Phe Asp Arg Pro 
                965                 970                 975     


Arg Glu Ala Leu Ala Leu Ala Leu Asp Gln Glu Arg Thr Val Thr Asp 
            980                 985                 990         


Gln Val Gly Arg Leu Thr Ala Val  Ala Arg Asp Glu Gly  Asp Phe Leu 
        995                 1000                 1005             


Gly Glu  Gln Phe Met Gln Trp  Phe Leu Gln Glu Gln  Ile Glu Glu 
    1010                 1015                 1020             


Val Ala  Leu Met Ala Thr Leu  Val Arg Val Ala Asp  Arg Ala Gly 
    1025                 1030                 1035             


Ala Asn  Leu Phe Glu Leu Glu  Asn Phe Val Ala Arg  Glu Val Asp 
    1040                 1045                 1050             


Val Ala  Pro Ala Ala Ser Gly  Ala Pro His Ala Ala  Gly Gly Arg 
    1055                 1060                 1065             


His His  His His His His 
    1070                 


<210>  34
<211>  505
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys Ser Arg Val Gln Leu 
1               5                   10                  15      


Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln Pro Trp Arg Trp Ile 
            20                  25                  30          


Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp Lys Asp Arg Val Leu 
        35                  40                  45              


Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu Leu Gly Cys Gly Ala 
    50                  55                  60                  


Val Leu Asp His Phe Arg Val Ala Met Ala Ala Ala Gly Thr Thr Ala 
65                  70                  75                  80  


Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro Leu His Leu Ala Ser 
                85                  90                  95      


Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu Gly His Arg Leu Arg 
            100                 105                 110         


Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg Leu Pro Phe Ala Glu 
        115                 120                 125             


Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu Arg Thr Thr Val Thr 
    130                 135                 140                 


Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp Asp Met Arg Pro Glu 
145                 150                 155                 160 


Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu Arg Leu Tyr Asp Ser 
                165                 170                 175     


Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly Ala Phe Glu Thr Ser 
            180                 185                 190         


Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala Ala Glu Ser Asp Arg 
        195                 200                 205             


Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala Asn Thr Asp Arg Arg 
    210                 215                 220                 


Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu Val Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly Glu Met Leu Ser Ala 
                245                 250                 255     


Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala Thr Cys Thr Leu Thr 
            260                 265                 270         


His Ile Thr Glu Leu His Ala Ser Arg Asp Leu Val Ala Ala Leu Ile 
        275                 280                 285             


Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg Val Gly Leu Ala Pro 
    290                 295                 300                 


Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg Arg Pro Ile Asp Glu 
305                 310                 315                 320 


Val Phe His Val Arg Ala Lys Asp His Arg Thr Glu Tyr Glu Gly Pro 
                325                 330                 335     


Lys Thr Lys Phe His Ala Leu Met Gln Glu Gln Ile His Asn Glu Phe 
            340                 345                 350         


Thr Ala Ala Gln Gln Tyr Val Ala Ile Ala Val Tyr Phe Asp Ser Glu 
        355                 360                 365             


Asp Leu Pro Gln Leu Ala Lys His Phe Tyr Ser Gln Ala Val Glu Ala 
    370                 375                 380                 


Met Met Leu Val Gln His Leu Leu Asp Arg Asp Leu Arg Val Glu Ile 
385                 390                 395                 400 


Pro Gly Val Asp Thr Val Arg Asn Gln Phe Asp Arg Pro Arg Glu Ala 
                405                 410                 415     


Leu Ala Leu Ala Leu Asp Gln Glu Arg Thr Val Thr Asp Gln Val Gly 
            420                 425                 430         


Arg Leu Thr Ala Val Ala Arg Asp Glu Gly Asp Phe Leu Gly Glu Gln 
        435                 440                 445             


Phe Met Gln Trp Phe Leu Gln Glu Gln Ile Glu Glu Val Ala Leu Met 
    450                 455                 460                 


Ala Thr Leu Val Arg Val Ala Asp Arg Ala Gly Ala Asn Leu Phe Glu 
465                 470                 475                 480 


Leu Glu Asn Phe Val Ala Arg Glu Val Asp Val Ala Pro Ala Ala Ser 
                485                 490                 495     


Gly Ala Pro His Ala Ala Gly Gly Arg 
            500                 505 


<210>  35
<211>  1560
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1560)

<400>  35
atg gcc gac gag gca cca act agt cct gat aca atg gta aca act gac         48
Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp           
1               5                   10                  15                

gtt atc aaa tct aga gta caa ttg gct tgc aga gcc cca tca tta cat         96
Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His           
            20                  25                  30                    

aat tcc caa cca tgg cgc tgg att gcc gag gat cac aca gtg gca cta        144
Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu           
        35                  40                  45                        

ttc tta gac aaa gat aga gtt ctt tat gct aca gat cat agt ggc aga        192
Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg           
    50                  55                  60                            

gaa gca ctg ctg gga tgt ggt gct gtc cta gac cac ttc aga gtt gct        240
Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala           
65                  70                  75                  80            

atg gct gcg gcg ggc acc aca gca aat gtc gaa cga ttc cca aat cct        288
Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro           
                85                  90                  95                

aac gat cca tta cat ctt gca tct att gac ttt tct cct gct gat ttt        336
Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe           
            100                 105                 110                   

gtc aca gaa ggc cac aga ttg aga gct gat gcg atc tta ttg agg aga        384
Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg           
        115                 120                 125                       

aca gat aga ttg cct ttc gct gag cct cca gac tgg gac tta gta gaa        432
Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu           
    130                 135                 140                           

tca cag ttg agg act aca gtt act gct gat acc gtt aga atc gat gtt        480
Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val           
145                 150                 155                 160           

ata gcg gat gat atg agg cca gaa ctt gca gcc gca tcc aaa ttg acc        528
Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr           
                165                 170                 175               

gaa tct ttg aga cta tac gat agc tct tac cat gcg gaa ctg ttt tgg        576
Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp           
            180                 185                 190                   

tgg act ggt gct ttc gaa aca tct gaa ggg ata cca cat tct tca tta        624
Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu           
        195                 200                 205                       

gtt tca gct gca gaa tcc gat aga gtc act ttt ggt cgt gat ttc cca        672
Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro           
    210                 215                 220                           

gtc gta gca aat act gac aga cga cct gaa ttt ggt cat gac aga tct        720
Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser           
225                 230                 235                 240           

aaa gta ctt gtt ctc agc acc tac gat aat gaa agg gct tct ttg tta        768
Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu           
                245                 250                 255               

aga tgc ggt gaa atg cta agt gcc gtc tta ctg gat gcg act atg gct        816
Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala           
            260                 265                 270                   

gga ttg gca act tgt aca ctg acc cat atc acg gaa ctg cat gca tca        864
Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser           
        275                 280                 285                       

aga gat ctc gta gca gcc ttg att ggc caa cca gcc aca cct caa gcc        912
Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala           
    290                 295                 300                           

ctt gtg aga gta gga ttg gct cca gag atg gag gaa cca cct cct gct        960
Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala           
305                 310                 315                 320           

act cca cgt aga ccc atc gac gaa gtg ttc cat gtg aga gct aag gat       1008
Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp           
                325                 330                 335               

cat aga aca gaa tac gaa gga cca aag aca aag ttt cac gct ctt atg       1056
His Arg Thr Glu Tyr Glu Gly Pro Lys Thr Lys Phe His Ala Leu Met           
            340                 345                 350                   

caa gag caa atc cac aac gaa ttt act gct gct cag caa tac gtt gca       1104
Gln Glu Gln Ile His Asn Glu Phe Thr Ala Ala Gln Gln Tyr Val Ala           
        355                 360                 365                       

ata gcc gta tac ttt gat tca gaa gat ttg cca caa ttg gca aaa cat       1152
Ile Ala Val Tyr Phe Asp Ser Glu Asp Leu Pro Gln Leu Ala Lys His           
    370                 375                 380                           

ttc tat tcc caa gcc gtg gag gcc atg atg tta gtt caa cac ctc cta       1200
Phe Tyr Ser Gln Ala Val Glu Ala Met Met Leu Val Gln His Leu Leu           
385                 390                 395                 400           

gac aga gat ttg aga gtt gaa att cca ggt gtt gat aca gtc aga aac       1248
Asp Arg Asp Leu Arg Val Glu Ile Pro Gly Val Asp Thr Val Arg Asn           
                405                 410                 415               

caa ttt gat aga cct cgt gaa gca ttg gct cta gca tta gat cag gag       1296
Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala Leu Ala Leu Asp Gln Glu           
            420                 425                 430                   

aga act gtg acg gat caa gtg ggt aga ttg aca gct gtt gca cgt gac       1344
Arg Thr Val Thr Asp Gln Val Gly Arg Leu Thr Ala Val Ala Arg Asp           
        435                 440                 445                       

gaa gga gac ttt ctt ggg gag cag ttt atg caa tgg ttt ctc cag gaa       1392
Glu Gly Asp Phe Leu Gly Glu Gln Phe Met Gln Trp Phe Leu Gln Glu           
    450                 455                 460                           

caa att gaa gag gtt gca cta atg gca act tta gtg aga gtc gct gac       1440
Gln Ile Glu Glu Val Ala Leu Met Ala Thr Leu Val Arg Val Ala Asp           
465                 470                 475                 480           

aga gct ggt gct aat ctc ttc gaa tta gaa aac ttt gta gcc aga gag       1488
Arg Ala Gly Ala Asn Leu Phe Glu Leu Glu Asn Phe Val Ala Arg Glu           
                485                 490                 495               

gtt gat gtt gca cca gca gcc tca ggt gcc cct cac gct gcc ggg ggc       1536
Val Asp Val Ala Pro Ala Ala Ser Gly Ala Pro His Ala Ala Gly Gly           
            500                 505                 510                   

aga cat cat cac cat cac cat taa                                       1560
Arg His His His His His His                                               
        515                                                               


<210>  36
<211>  519
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp 
1               5                   10                  15      


Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His 
            20                  25                  30          


Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu 
        35                  40                  45              


Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg 
    50                  55                  60                  


Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala 
65                  70                  75                  80  


Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro 
                85                  90                  95      


Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe 
            100                 105                 110         


Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg 
        115                 120                 125             


Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu 
    130                 135                 140                 


Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val 
145                 150                 155                 160 


Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr 
                165                 170                 175     


Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp 
            180                 185                 190         


Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu 
        195                 200                 205             


Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro 
    210                 215                 220                 


Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser 
225                 230                 235                 240 


Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu 
                245                 250                 255     


Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala 
            260                 265                 270         


Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser 
        275                 280                 285             


Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala 
    290                 295                 300                 


Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp 
                325                 330                 335     


His Arg Thr Glu Tyr Glu Gly Pro Lys Thr Lys Phe His Ala Leu Met 
            340                 345                 350         


Gln Glu Gln Ile His Asn Glu Phe Thr Ala Ala Gln Gln Tyr Val Ala 
        355                 360                 365             


Ile Ala Val Tyr Phe Asp Ser Glu Asp Leu Pro Gln Leu Ala Lys His 
    370                 375                 380                 


Phe Tyr Ser Gln Ala Val Glu Ala Met Met Leu Val Gln His Leu Leu 
385                 390                 395                 400 


Asp Arg Asp Leu Arg Val Glu Ile Pro Gly Val Asp Thr Val Arg Asn 
                405                 410                 415     


Gln Phe Asp Arg Pro Arg Glu Ala Leu Ala Leu Ala Leu Asp Gln Glu 
            420                 425                 430         


Arg Thr Val Thr Asp Gln Val Gly Arg Leu Thr Ala Val Ala Arg Asp 
        435                 440                 445             


Glu Gly Asp Phe Leu Gly Glu Gln Phe Met Gln Trp Phe Leu Gln Glu 
    450                 455                 460                 


Gln Ile Glu Glu Val Ala Leu Met Ala Thr Leu Val Arg Val Ala Asp 
465                 470                 475                 480 


Arg Ala Gly Ala Asn Leu Phe Glu Leu Glu Asn Phe Val Ala Arg Glu 
                485                 490                 495     


Val Asp Val Ala Pro Ala Ala Ser Gly Ala Pro His Ala Ala Gly Gly 
            500                 505                 510         


Arg His His His His His His 
        515                 


<210>  37
<211>  337
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  37

Gln Leu Val Asp Arg Val Arg Gly Ala Val Thr Gly Met Ser Arg Arg 
1               5                   10                  15      


Leu Val Val Gly Ala Val Gly Ala Ala Leu Val Ser Gly Leu Val Gly 
            20                  25                  30          


Ala Val Gly Gly Thr Ala Thr Ala Gly Ala Phe Ser Arg Pro Gly Leu 
        35                  40                  45              


Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly Arg Asp Ile 
    50                  55                  60                  


Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala Leu Tyr Leu 
65                  70                  75                  80  


Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp Asp Ile Asn 
                85                  90                  95      


Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser Val Val Met 
            100                 105                 110         


Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Gln Pro Ala 
        115                 120                 125             


Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr Phe Leu Thr 
    130                 135                 140                 


Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro Thr 
145                 150                 155                 160 


Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser Ala Leu Thr 
                165                 170                 175     


Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly Ala Met Ser 
            180                 185                 190         


Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu Ile Gly Leu 
        195                 200                 205             


Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met Trp Gly Pro 
    210                 215                 220                 


Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu Asn Val Gly 
225                 230                 235                 240 


Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys Gly Asn Gly 
                245                 250                 255     


Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys Phe Leu Glu 
            260                 265                 270         


Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala Tyr Asn Ala 
        275                 280                 285             


Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser Gly Thr His 
    290                 295                 300                 


Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys Pro Asp Leu 
305                 310                 315                 320 


Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala Pro Gln Gly 
                325                 330                 335     


Ala 
    


<210>  38
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1056)

<400>  38
atg gcc gac gag gca cca act agt caa tta gta gat aga gtc aga gga         48
Met Ala Asp Glu Ala Pro Thr Ser Gln Leu Val Asp Arg Val Arg Gly           
1               5                   10                  15                

gca gtt aca ggt atg tcc aga aga ttg gtt gta ggt gcc gtt ggg gct         96
Ala Val Thr Gly Met Ser Arg Arg Leu Val Val Gly Ala Val Gly Ala           
            20                  25                  30                    

gct ttg gtt tca ggt ttg gtt ggg gct gtg ggc ggt aca gct act gca        144
Ala Leu Val Ser Gly Leu Val Gly Ala Val Gly Gly Thr Ala Thr Ala           
        35                  40                  45                        

ggg gct ttt tct aga cct ggc ctg cca gtg gaa tac ctt caa gtc cct        192
Gly Ala Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro           
    50                  55                  60                            

tca cca tca atg ggt cgt gac att aag gtc caa ttt caa tca ggt ggt        240
Ser Pro Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly           
65                  70                  75                  80            

gca aat tcc cca gct ctg tac ctg tta gat gga ctt aga gca caa gat        288
Ala Asn Ser Pro Ala Leu Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp           
                85                  90                  95                

gat ttt tct gga tgg gat atc aac act cct gcc ttt gaa tgg tat gat        336
Asp Phe Ser Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Asp           
            100                 105                 110                   

cag tct ggt tta agc gtt gtt atg cca gtc ggt ggt caa tcg tca ttc        384
Gln Ser Gly Leu Ser Val Val Met Pro Val Gly Gly Gln Ser Ser Phe           
        115                 120                 125                       

tac tct gat tgg tat caa cca gcc tgt ggt aag gct gga tgc caa aca        432
Tyr Ser Asp Trp Tyr Gln Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr           
    130                 135                 140                           

tac aaa tgg gaa acc ttt ttg acg tct gaa tta cct gga tgg ttg caa        480
Tyr Lys Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln           
145                 150                 155                 160           

gct aat aga cac gtg aag cct act ggc tca gct gtt gta ggg ctt tca        528
Ala Asn Arg His Val Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser           
                165                 170                 175               

atg gca gcc agt agt gca cta aca cta gcc ata tac cat cca caa cag        576
Met Ala Ala Ser Ser Ala Leu Thr Leu Ala Ile Tyr His Pro Gln Gln           
            180                 185                 190                   

ttc gta tat gcg ggt gct atg agc ggc ttg ttg gac cca tct caa gca        624
Phe Val Tyr Ala Gly Ala Met Ser Gly Leu Leu Asp Pro Ser Gln Ala           
        195                 200                 205                       

atg gga cct act ctc atc ggt cta gca atg gga gat gca gga gga tac        672
Met Gly Pro Thr Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr           
    210                 215                 220                           

aaa gcc tcc gat atg tgg ggc ccc aaa gag gat cca gct tgg cag aga        720
Lys Ala Ser Asp Met Trp Gly Pro Lys Glu Asp Pro Ala Trp Gln Arg           
225                 230                 235                 240           

aat gac cca ttg ttg aat gta ggt aaa cta att gcg aac aac aca cga        768
Asn Asp Pro Leu Leu Asn Val Gly Lys Leu Ile Ala Asn Asn Thr Arg           
                245                 250                 255               

gtg tgg gtc tat tgt ggc aac ggc aag cca tct gat ctt ggg ggt aat        816
Val Trp Val Tyr Cys Gly Asn Gly Lys Pro Ser Asp Leu Gly Gly Asn           
            260                 265                 270                   

aac ctt cct gct aaa ttc tta gaa ggc ttc gtg aga aca tct aac atc        864
Asn Leu Pro Ala Lys Phe Leu Glu Gly Phe Val Arg Thr Ser Asn Ile           
        275                 280                 285                       

aag ttc caa gac gcc tac aat gct ggc ggt ggt cat aat ggg gtt ttt        912
Lys Phe Gln Asp Ala Tyr Asn Ala Gly Gly Gly His Asn Gly Val Phe           
    290                 295                 300                           

gac ttt cca gat tcc ggt act cac tct tgg gaa tac tgg gga gca cag        960
Asp Phe Pro Asp Ser Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln           
305                 310                 315                 320           

tta aat gct atg aaa cct gac tta caa agg gct ctc ggt gcc aca cca       1008
Leu Asn Ala Met Lys Pro Asp Leu Gln Arg Ala Leu Gly Ala Thr Pro           
                325                 330                 335               

aat acc ggt cca gcg cct caa ggc gcg cat cac cat cat cat cac taa       1056
Asn Thr Gly Pro Ala Pro Gln Gly Ala His His His His His His               
            340                 345                 350                   


<210>  39
<211>  351
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  39

Met Ala Asp Glu Ala Pro Thr Ser Gln Leu Val Asp Arg Val Arg Gly 
1               5                   10                  15      


Ala Val Thr Gly Met Ser Arg Arg Leu Val Val Gly Ala Val Gly Ala 
            20                  25                  30          


Ala Leu Val Ser Gly Leu Val Gly Ala Val Gly Gly Thr Ala Thr Ala 
        35                  40                  45              


Gly Ala Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro 
    50                  55                  60                  


Ser Pro Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly 
65                  70                  75                  80  


Ala Asn Ser Pro Ala Leu Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp 
                85                  90                  95      


Asp Phe Ser Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Asp 
            100                 105                 110         


Gln Ser Gly Leu Ser Val Val Met Pro Val Gly Gly Gln Ser Ser Phe 
        115                 120                 125             


Tyr Ser Asp Trp Tyr Gln Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr 
    130                 135                 140                 


Tyr Lys Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln 
145                 150                 155                 160 


Ala Asn Arg His Val Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser 
                165                 170                 175     


Met Ala Ala Ser Ser Ala Leu Thr Leu Ala Ile Tyr His Pro Gln Gln 
            180                 185                 190         


Phe Val Tyr Ala Gly Ala Met Ser Gly Leu Leu Asp Pro Ser Gln Ala 
        195                 200                 205             


Met Gly Pro Thr Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr 
    210                 215                 220                 


Lys Ala Ser Asp Met Trp Gly Pro Lys Glu Asp Pro Ala Trp Gln Arg 
225                 230                 235                 240 


Asn Asp Pro Leu Leu Asn Val Gly Lys Leu Ile Ala Asn Asn Thr Arg 
                245                 250                 255     


Val Trp Val Tyr Cys Gly Asn Gly Lys Pro Ser Asp Leu Gly Gly Asn 
            260                 265                 270         


Asn Leu Pro Ala Lys Phe Leu Glu Gly Phe Val Arg Thr Ser Asn Ile 
        275                 280                 285             


Lys Phe Gln Asp Ala Tyr Asn Ala Gly Gly Gly His Asn Gly Val Phe 
    290                 295                 300                 


Asp Phe Pro Asp Ser Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln 
305                 310                 315                 320 


Leu Asn Ala Met Lys Pro Asp Leu Gln Arg Ala Leu Gly Ala Thr Pro 
                325                 330                 335     


Asn Thr Gly Pro Ala Pro Gln Gly Ala His His His His His His 
            340                 345                 350     


<210>  40
<211>  236
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  40

Met Arg Thr Pro Arg Arg His Cys Arg Arg Ile Ala Val Leu Ala Ala 
1               5                   10                  15      


Val Ser Ile Ala Ala Thr Val Val Ala Gly Cys Ser Ser Gly Ser Lys 
            20                  25                  30          


Pro Ser Gly Gly Pro Leu Pro Asp Ala Lys Pro Leu Val Glu Glu Ala 
        35                  40                  45              


Thr Ala Gln Thr Lys Ala Leu Lys Ser Ala His Met Val Leu Thr Val 
    50                  55                  60                  


Asn Gly Lys Ile Pro Gly Leu Ser Leu Lys Thr Leu Ser Gly Asp Leu 
65                  70                  75                  80  


Thr Thr Asn Pro Thr Ala Ala Thr Gly Asn Trp Lys Leu Thr Leu Gly 
                85                  90                  95      


Gly Ser Asp Ile Asp Ala Asp Phe Val Val Phe Asp Gly Ile Leu Tyr 
            100                 105                 110         


Ala Thr Leu Thr Pro Asn Gln Trp Ser Asp Phe Gly Pro Ala Ala Asp 
        115                 120                 125             


Ile Tyr Asp Pro Ala Gln Val Leu Asn Pro Asp Thr Gly Leu Ala Asn 
    130                 135                 140                 


Val Leu Ala Asn Phe Ala Asp Ala Lys Ala Glu Gly Arg Asp Thr Ile 
145                 150                 155                 160 


Asn Gly Gln Asn Thr Ile Arg Ile Ser Gly Lys Val Ser Ala Gln Ala 
                165                 170                 175     


Val Asn Gln Ile Ala Pro Pro Phe Asn Ala Thr Gln Pro Val Pro Ala 
            180                 185                 190         


Thr Val Trp Ile Gln Glu Thr Gly Asp His Gln Leu Ala Gln Ala Gln 
        195                 200                 205             


Leu Asp Arg Gly Ser Gly Asn Ser Val Gln Met Thr Leu Ser Lys Trp 
    210                 215                 220                 


Gly Glu Lys Val Gln Val Thr Lys Pro Pro Val Ser 
225                 230                 235     


<210>  41
<211>  753
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(753)

<400>  41
atg gcc gac gag gca cca act agt atg aga aca cca aga cgt cac tgt         48
Met Ala Asp Glu Ala Pro Thr Ser Met Arg Thr Pro Arg Arg His Cys           
1               5                   10                  15                

agg aga ata gcc gtt tta gct gca gtc tca att gca gca aca gta gtc         96
Arg Arg Ile Ala Val Leu Ala Ala Val Ser Ile Ala Ala Thr Val Val           
            20                  25                  30                    

gct ggt tgc tca tct ggc tca aag cca tcc gga ggc cct ttg ccc gat        144
Ala Gly Cys Ser Ser Gly Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp           
        35                  40                  45                        

gct aag cca ctc gta gaa gag gcc aca gct caa act aaa gca cta aag        192
Ala Lys Pro Leu Val Glu Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys           
    50                  55                  60                            

tct gcg cat atg gtg ctt aca gta aat ggt aaa atc cca ggg ctt tca        240
Ser Ala His Met Val Leu Thr Val Asn Gly Lys Ile Pro Gly Leu Ser           
65                  70                  75                  80            

ttg aaa act cta tct ggt gat tta aca acc aat cca acg gct gct aca        288
Leu Lys Thr Leu Ser Gly Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr           
                85                  90                  95                

ggt aac tgg aag tta aca cta gga ggc tca gac atc gat gcg gat ttt        336
Gly Asn Trp Lys Leu Thr Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe           
            100                 105                 110                   

gtt gtg ttt gac gga atc ttg tat gct acc ttg act cca aac caa tgg        384
Val Val Phe Asp Gly Ile Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp           
        115                 120                 125                       

tct gat ttc ggt cca gcc gct gac att tac gat cct gca caa gtt ctt        432
Ser Asp Phe Gly Pro Ala Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu           
    130                 135                 140                           

aac cct gat aca gga ttg gca aat gta ctg gca aat ttc gct gac gcg        480
Asn Pro Asp Thr Gly Leu Ala Asn Val Leu Ala Asn Phe Ala Asp Ala           
145                 150                 155                 160           

aaa gcc gaa ggg aga gat acc atc aat ggt caa aac acg att aga ata        528
Lys Ala Glu Gly Arg Asp Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile           
                165                 170                 175               

agc ggt aaa gtg tct gcc caa gca gtc aat caa atc gct cct cca ttt        576
Ser Gly Lys Val Ser Ala Gln Ala Val Asn Gln Ile Ala Pro Pro Phe           
            180                 185                 190                   

aac gct act cag cct gtt cct gca act gtt tgg att cag gaa act ggt        624
Asn Ala Thr Gln Pro Val Pro Ala Thr Val Trp Ile Gln Glu Thr Gly           
        195                 200                 205                       

gat cat cag tta gcc caa gct caa ctc gat aga ggc tcc gga aat agt        672
Asp His Gln Leu Ala Gln Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser           
    210                 215                 220                           

gtt caa atg act ctg tcc aag tgg ggt gaa aaa gtg caa gtt aca aaa        720
Val Gln Met Thr Leu Ser Lys Trp Gly Glu Lys Val Gln Val Thr Lys           
225                 230                 235                 240           

cca cca gtc tct cac cat cac cat cat cat taa                            753
Pro Pro Val Ser His His His His His His                                   
                245                 250                                   


<210>  42
<211>  250
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Met Ala Asp Glu Ala Pro Thr Ser Met Arg Thr Pro Arg Arg His Cys 
1               5                   10                  15      


Arg Arg Ile Ala Val Leu Ala Ala Val Ser Ile Ala Ala Thr Val Val 
            20                  25                  30          


Ala Gly Cys Ser Ser Gly Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp 
        35                  40                  45              


Ala Lys Pro Leu Val Glu Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys 
    50                  55                  60                  


Ser Ala His Met Val Leu Thr Val Asn Gly Lys Ile Pro Gly Leu Ser 
65                  70                  75                  80  


Leu Lys Thr Leu Ser Gly Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr 
                85                  90                  95      


Gly Asn Trp Lys Leu Thr Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe 
            100                 105                 110         


Val Val Phe Asp Gly Ile Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp 
        115                 120                 125             


Ser Asp Phe Gly Pro Ala Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu 
    130                 135                 140                 


Asn Pro Asp Thr Gly Leu Ala Asn Val Leu Ala Asn Phe Ala Asp Ala 
145                 150                 155                 160 


Lys Ala Glu Gly Arg Asp Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile 
                165                 170                 175     


Ser Gly Lys Val Ser Ala Gln Ala Val Asn Gln Ile Ala Pro Pro Phe 
            180                 185                 190         


Asn Ala Thr Gln Pro Val Pro Ala Thr Val Trp Ile Gln Glu Thr Gly 
        195                 200                 205             


Asp His Gln Leu Ala Gln Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser 
    210                 215                 220                 


Val Gln Met Thr Leu Ser Lys Trp Gly Glu Lys Val Gln Val Thr Lys 
225                 230                 235                 240 


Pro Pro Val Ser His His His His His His 
                245                 250 


<210>  43
<211>  695
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  43

Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys Ser Arg Val Gln Leu 
1               5                   10                  15      


Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln Pro Trp Arg Trp Ile 
            20                  25                  30          


Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp Lys Asp Arg Val Leu 
        35                  40                  45              


Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu Leu Gly Cys Gly Ala 
    50                  55                  60                  


Val Leu Asp His Phe Arg Val Ala Met Ala Ala Ala Gly Thr Thr Ala 
65                  70                  75                  80  


Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro Leu His Leu Ala Ser 
                85                  90                  95      


Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu Gly His Arg Leu Arg 
            100                 105                 110         


Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg Leu Pro Phe Ala Glu 
        115                 120                 125             


Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu Arg Thr Thr Val Thr 
    130                 135                 140                 


Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp Asp Met Arg Pro Glu 
145                 150                 155                 160 


Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu Arg Leu Tyr Asp Ser 
                165                 170                 175     


Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly Ala Phe Glu Thr Ser 
            180                 185                 190         


Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala Ala Glu Ser Asp Arg 
        195                 200                 205             


Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala Asn Thr Asp Arg Arg 
    210                 215                 220                 


Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu Val Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly Glu Met Leu Ser Ala 
                245                 250                 255     


Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala Thr Cys Thr Leu Thr 
            260                 265                 270         


His Ile Thr Glu Leu His Ala Ser Arg Asp Leu Val Ala Ala Leu Ile 
        275                 280                 285             


Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg Val Gly Leu Ala Pro 
    290                 295                 300                 


Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg Arg Pro Ile Asp Glu 
305                 310                 315                 320 


Val Phe His Val Arg Ala Lys Asp His Arg Met Arg Thr Pro Arg Arg 
                325                 330                 335     


His Cys Arg Arg Ile Ala Val Leu Ala Ala Val Ser Ile Ala Ala Thr 
            340                 345                 350         


Val Val Ala Gly Cys Ser Ser Gly Ser Lys Pro Ser Gly Gly Pro Leu 
        355                 360                 365             


Pro Asp Ala Lys Pro Leu Val Glu Glu Ala Thr Ala Gln Thr Lys Ala 
    370                 375                 380                 


Leu Lys Ser Ala His Met Val Leu Thr Val Asn Gly Lys Ile Pro Gly 
385                 390                 395                 400 


Leu Ser Leu Lys Thr Leu Ser Gly Asp Leu Thr Thr Asn Pro Thr Ala 
                405                 410                 415     


Ala Thr Gly Asn Trp Lys Leu Thr Leu Gly Gly Ser Asp Ile Asp Ala 
            420                 425                 430         


Asp Phe Val Val Phe Asp Gly Ile Leu Tyr Ala Thr Leu Thr Pro Asn 
        435                 440                 445             


Gln Trp Ser Asp Phe Gly Pro Ala Ala Asp Ile Tyr Asp Pro Ala Gln 
    450                 455                 460                 


Val Leu Asn Pro Asp Thr Gly Leu Ala Asn Val Leu Ala Asn Phe Ala 
465                 470                 475                 480 


Asp Ala Lys Ala Glu Gly Arg Asp Thr Ile Asn Gly Gln Asn Thr Ile 
                485                 490                 495     


Arg Ile Ser Gly Lys Val Ser Ala Gln Ala Val Asn Gln Ile Ala Pro 
            500                 505                 510         


Pro Phe Asn Ala Thr Gln Pro Val Pro Ala Thr Val Trp Ile Gln Glu 
        515                 520                 525             


Thr Gly Asp His Gln Leu Ala Gln Ala Gln Leu Asp Arg Gly Ser Gly 
    530                 535                 540                 


Asn Ser Val Gln Met Thr Leu Ser Lys Trp Gly Glu Lys Val Gln Val 
545                 550                 555                 560 


Thr Lys Pro Pro Val Ser Ser Ala Ala Gly Val Arg Ser Thr Arg Gln 
                565                 570                 575     


Arg Ala Ala Ile Ser Thr Leu Leu Glu Thr Leu Asp Asp Phe Arg Ser 
            580                 585                 590         


Ala Gln Glu Leu His Asp Glu Leu Arg Arg Arg Gly Glu Asn Ile Gly 
        595                 600                 605             


Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Met Ala Ser Ser Gly Leu 
    610                 615                 620                 


Val Asp Thr Leu His Thr Asp Thr Gly Glu Ser Val Tyr Arg Arg Cys 
625                 630                 635                 640 


Ser Glu His His His His His Leu Val Cys Arg Ser Cys Gly Ser Thr 
                645                 650                 655     


Ile Glu Val Gly Asp His Glu Val Glu Ala Trp Ala Ala Glu Val Ala 
            660                 665                 670         


Thr Lys His Gly Phe Ser Asp Val Ser His Thr Ile Glu Ile Phe Gly 
        675                 680                 685             


Thr Cys Ser Asp Cys Arg Ser 
    690                 695 


<210>  44
<211>  2130
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(2130)

<400>  44
atg gcc gac gag gca cca act agt cct gat aca atg gta aca act gac         48
Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp           
1               5                   10                  15                

gtt atc aaa tct aga gta caa ttg gct tgc aga gcc cca tca tta cat         96
Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His           
            20                  25                  30                    

aat tcc caa cca tgg cgc tgg att gcc gag gat cac aca gtg gca cta        144
Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu           
        35                  40                  45                        

ttc tta gac aaa gat aga gtt ctt tat gct aca gat cat agt ggc aga        192
Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg           
    50                  55                  60                            

gaa gca ctg ctg gga tgt ggt gct gtc cta gac cac ttc aga gtt gct        240
Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala           
65                  70                  75                  80            

atg gct gcg gcg ggc acc aca gca aat gtc gaa cga ttc cca aat cct        288
Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro           
                85                  90                  95                

aac gat cca tta cat ctt gca tct att gac ttt tct cct gct gat ttt        336
Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe           
            100                 105                 110                   

gtc aca gaa ggc cac aga ttg aga gct gat gcg atc tta ttg agg aga        384
Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg           
        115                 120                 125                       

aca gat aga ttg cct ttc gct gag cct cca gac tgg gac tta gta gaa        432
Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu           
    130                 135                 140                           

tca cag ttg agg act aca gtt act gct gat acc gtt aga atc gat gtt        480
Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val           
145                 150                 155                 160           

ata gcg gat gat atg agg cca gaa ctt gca gcc gca tcc aaa ttg acc        528
Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr           
                165                 170                 175               

gaa tct ttg aga cta tac gat agc tct tac cat gcg gaa ctg ttt tgg        576
Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp           
            180                 185                 190                   

tgg act ggt gct ttc gaa aca tct gaa ggg ata cca cat tct tca tta        624
Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu           
        195                 200                 205                       

gtt tca gct gca gaa tcc gat aga gtc act ttt ggt cgt gat ttc cca        672
Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro           
    210                 215                 220                           

gtc gta gca aat act gac aga cga cct gaa ttt ggt cat gac aga tct        720
Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser           
225                 230                 235                 240           

aaa gta ctt gtt ctc agc acc tac gat aat gaa agg gct tct ttg tta        768
Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu           
                245                 250                 255               

aga tgc ggt gaa atg cta agt gcc gtc tta ctg gat gcg act atg gct        816
Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala           
            260                 265                 270                   

gga ttg gca act tgt aca ctg acc cat atc acg gaa ctg cat gca tca        864
Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser           
        275                 280                 285                       

aga gat ctc gta gca gcc ttg att ggc caa cca gcc aca cct caa gcc        912
Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala           
    290                 295                 300                           

ctt gtg aga gta gga ttg gct cca gag atg gag gaa cca cct cct gct        960
Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala           
305                 310                 315                 320           

act cca cgt aga ccc atc gac gaa gtg ttc cat gtg aga gct aag gat       1008
Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp           
                325                 330                 335               

cat aga atg aga act cca agg aga cat tgt cgt aga atc gcc gtg ctc       1056
His Arg Met Arg Thr Pro Arg Arg His Cys Arg Arg Ile Ala Val Leu           
            340                 345                 350                   

gca gca gtc agt atc gcc gca aca gtc gtt gct ggt tgc tca tct ggt       1104
Ala Ala Val Ser Ile Ala Ala Thr Val Val Ala Gly Cys Ser Ser Gly           
        355                 360                 365                       

tca aaa cca tct ggt ggc cca ctt cca gac gcc aag cct ttg gtg gaa       1152
Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp Ala Lys Pro Leu Val Glu           
    370                 375                 380                           

gag gca aca gct cag act aag gcg ttg aag tcc gca cac atg gtt cta       1200
Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys Ser Ala His Met Val Leu           
385                 390                 395                 400           

act gtt aat ggt aaa att cct ggg cta tca ctt aag aca cta tct gga       1248
Thr Val Asn Gly Lys Ile Pro Gly Leu Ser Leu Lys Thr Leu Ser Gly           
                405                 410                 415               

gat ctc act acc aat cca aca gct gct acg ggt aac tgg aaa ctt aca       1296
Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr Gly Asn Trp Lys Leu Thr           
            420                 425                 430                   

ttg gga ggt tca gac atc gat gct gac ttt gtg gta ttt gat ggt att       1344
Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe Val Val Phe Asp Gly Ile           
        435                 440                 445                       

ttg tac gct acc tta aca cca aac caa tgg tca gat ttt gga cca gcc       1392
Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp Ser Asp Phe Gly Pro Ala           
    450                 455                 460                           

gca gat atc tac gat cct gct caa gtt cta aat cca gac aca ggt tta       1440
Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu Asn Pro Asp Thr Gly Leu           
465                 470                 475                 480           

gcg aac gtt ctt gct aat ttc gct gat gct aag gcc gaa ggg aga gac       1488
Ala Asn Val Leu Ala Asn Phe Ala Asp Ala Lys Ala Glu Gly Arg Asp           
                485                 490                 495               

acc att aac ggt caa aat act att aga ata tct ggc aag gta tct gca       1536
Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile Ser Gly Lys Val Ser Ala           
            500                 505                 510                   

caa gcc gtc aac caa att gca cct cct ttt aac gct acc caa cca gtc       1584
Gln Ala Val Asn Gln Ile Ala Pro Pro Phe Asn Ala Thr Gln Pro Val           
        515                 520                 525                       

cca gct act gta tgg atc caa gag act gga gat cat cag tta gct caa       1632
Pro Ala Thr Val Trp Ile Gln Glu Thr Gly Asp His Gln Leu Ala Gln           
    530                 535                 540                           

gct caa ctg gac aga ggg agt ggc aat tcc gtt cag atg aca ctc tcc       1680
Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser Val Gln Met Thr Leu Ser           
545                 550                 555                 560           

aaa tgg ggc gag aag gtt caa gtc aca aaa cca cct gtt tca agt gct       1728
Lys Trp Gly Glu Lys Val Gln Val Thr Lys Pro Pro Val Ser Ser Ala           
                565                 570                 575               

gcc ggt gtg aga agc acg aga caa aga gca gcc atc tct acg ttg ctt       1776
Ala Gly Val Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu           
            580                 585                 590                   

gaa aca cta gat gac ttc aga tct gcc cag gag tta cac gat gaa tta       1824
Glu Thr Leu Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp Glu Leu           
        595                 600                 605                       

aga cgt agg ggg gag aat att ggc ttg act act gtt tac aga acc tta       1872
Arg Arg Arg Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu           
    610                 615                 620                           

caa tca atg gca tcc tcg gga ttg gtg gat act ttg cat act gat acg       1920
Gln Ser Met Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr Asp Thr           
625                 630                 635                 640           

gga gaa tca gtt tat aga aga tgc tct gaa cac cat cat cat cat ttg       1968
Gly Glu Ser Val Tyr Arg Arg Cys Ser Glu His His His His His Leu           
                645                 650                 655               

gtt tgt aga tca tgt gga tca aca ata gag gta ggt gac cat gaa gtc       2016
Val Cys Arg Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His Glu Val           
            660                 665                 670                   

gaa gca tgg gca gcc gag gtg gct act aaa cat ggt ttt tct gat gtt       2064
Glu Ala Trp Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser Asp Val           
        675                 680                 685                       

tct cat aca att gaa ata ttt ggc aca tgt agt gat tgt cgt tcc cac       2112
Ser His Thr Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg Ser His           
    690                 695                 700                           

cat cac cac cac cat taa                                               2130
His His His His His                                                       
705                                                                       


<210>  45
<211>  709
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  45

Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp 
1               5                   10                  15      


Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His 
            20                  25                  30          


Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu 
        35                  40                  45              


Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg 
    50                  55                  60                  


Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala 
65                  70                  75                  80  


Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro 
                85                  90                  95      


Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe 
            100                 105                 110         


Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg 
        115                 120                 125             


Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu 
    130                 135                 140                 


Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val 
145                 150                 155                 160 


Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr 
                165                 170                 175     


Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp 
            180                 185                 190         


Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu 
        195                 200                 205             


Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro 
    210                 215                 220                 


Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser 
225                 230                 235                 240 


Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu 
                245                 250                 255     


Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala 
            260                 265                 270         


Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser 
        275                 280                 285             


Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala 
    290                 295                 300                 


Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp 
                325                 330                 335     


His Arg Met Arg Thr Pro Arg Arg His Cys Arg Arg Ile Ala Val Leu 
            340                 345                 350         


Ala Ala Val Ser Ile Ala Ala Thr Val Val Ala Gly Cys Ser Ser Gly 
        355                 360                 365             


Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp Ala Lys Pro Leu Val Glu 
    370                 375                 380                 


Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys Ser Ala His Met Val Leu 
385                 390                 395                 400 


Thr Val Asn Gly Lys Ile Pro Gly Leu Ser Leu Lys Thr Leu Ser Gly 
                405                 410                 415     


Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr Gly Asn Trp Lys Leu Thr 
            420                 425                 430         


Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe Val Val Phe Asp Gly Ile 
        435                 440                 445             


Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp Ser Asp Phe Gly Pro Ala 
    450                 455                 460                 


Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu Asn Pro Asp Thr Gly Leu 
465                 470                 475                 480 


Ala Asn Val Leu Ala Asn Phe Ala Asp Ala Lys Ala Glu Gly Arg Asp 
                485                 490                 495     


Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile Ser Gly Lys Val Ser Ala 
            500                 505                 510         


Gln Ala Val Asn Gln Ile Ala Pro Pro Phe Asn Ala Thr Gln Pro Val 
        515                 520                 525             


Pro Ala Thr Val Trp Ile Gln Glu Thr Gly Asp His Gln Leu Ala Gln 
    530                 535                 540                 


Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser Val Gln Met Thr Leu Ser 
545                 550                 555                 560 


Lys Trp Gly Glu Lys Val Gln Val Thr Lys Pro Pro Val Ser Ser Ala 
                565                 570                 575     


Ala Gly Val Arg Ser Thr Arg Gln Arg Ala Ala Ile Ser Thr Leu Leu 
            580                 585                 590         


Glu Thr Leu Asp Asp Phe Arg Ser Ala Gln Glu Leu His Asp Glu Leu 
        595                 600                 605             


Arg Arg Arg Gly Glu Asn Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu 
    610                 615                 620                 


Gln Ser Met Ala Ser Ser Gly Leu Val Asp Thr Leu His Thr Asp Thr 
625                 630                 635                 640 


Gly Glu Ser Val Tyr Arg Arg Cys Ser Glu His His His His His Leu 
                645                 650                 655     


Val Cys Arg Ser Cys Gly Ser Thr Ile Glu Val Gly Asp His Glu Val 
            660                 665                 670         


Glu Ala Trp Ala Ala Glu Val Ala Thr Lys His Gly Phe Ser Asp Val 
        675                 680                 685             


Ser His Thr Ile Glu Ile Phe Gly Thr Cys Ser Asp Cys Arg Ser His 
    690                 695                 700                 


His His His His His 
705                 


<210>  46
<211>  795
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Pro Asp Thr Met Val Thr Thr Asp Val Ile Lys Ser Arg Val Gln Leu 
1               5                   10                  15      


Ala Cys Arg Ala Pro Ser Leu His Asn Ser Gln Pro Trp Arg Trp Ile 
            20                  25                  30          


Ala Glu Asp His Thr Val Ala Leu Phe Leu Asp Lys Asp Arg Val Leu 
        35                  40                  45              


Tyr Ala Thr Asp His Ser Gly Arg Glu Ala Leu Leu Gly Cys Gly Ala 
    50                  55                  60                  


Val Leu Asp His Phe Arg Val Ala Met Ala Ala Ala Gly Thr Thr Ala 
65                  70                  75                  80  


Asn Val Glu Arg Phe Pro Asn Pro Asn Asp Pro Leu His Leu Ala Ser 
                85                  90                  95      


Ile Asp Phe Ser Pro Ala Asp Phe Val Thr Glu Gly His Arg Leu Arg 
            100                 105                 110         


Ala Asp Ala Ile Leu Leu Arg Arg Thr Asp Arg Leu Pro Phe Ala Glu 
        115                 120                 125             


Pro Pro Asp Trp Asp Leu Val Glu Ser Gln Leu Arg Thr Thr Val Thr 
    130                 135                 140                 


Ala Asp Thr Val Arg Ile Asp Val Ile Ala Asp Asp Met Arg Pro Glu 
145                 150                 155                 160 


Leu Ala Ala Ala Ser Lys Leu Thr Glu Ser Leu Arg Leu Tyr Asp Ser 
                165                 170                 175     


Ser Tyr His Ala Glu Leu Phe Trp Trp Thr Gly Ala Phe Glu Thr Ser 
            180                 185                 190         


Glu Gly Ile Pro His Ser Ser Leu Val Ser Ala Ala Glu Ser Asp Arg 
        195                 200                 205             


Val Thr Phe Gly Arg Asp Phe Pro Val Val Ala Asn Thr Asp Arg Arg 
    210                 215                 220                 


Pro Glu Phe Gly His Asp Arg Ser Lys Val Leu Val Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Asn Glu Arg Ala Ser Leu Leu Arg Cys Gly Glu Met Leu Ser Ala 
                245                 250                 255     


Val Leu Leu Asp Ala Thr Met Ala Gly Leu Ala Thr Cys Thr Leu Thr 
            260                 265                 270         


His Ile Thr Glu Leu His Ala Ser Arg Asp Leu Val Ala Ala Leu Ile 
        275                 280                 285             


Gly Gln Pro Ala Thr Pro Gln Ala Leu Val Arg Val Gly Leu Ala Pro 
    290                 295                 300                 


Glu Met Glu Glu Pro Pro Pro Ala Thr Pro Arg Arg Pro Ile Asp Glu 
305                 310                 315                 320 


Val Phe His Val Arg Ala Lys Asp His Arg Met Arg Thr Pro Arg Arg 
                325                 330                 335     


His Cys Arg Arg Ile Ala Val Leu Ala Ala Val Ser Ile Ala Ala Thr 
            340                 345                 350         


Val Val Ala Gly Cys Ser Ser Gly Ser Lys Pro Ser Gly Gly Pro Leu 
        355                 360                 365             


Pro Asp Ala Lys Pro Leu Val Glu Glu Ala Thr Ala Gln Thr Lys Ala 
    370                 375                 380                 


Leu Lys Ser Ala His Met Val Leu Thr Val Asn Gly Lys Ile Pro Gly 
385                 390                 395                 400 


Leu Ser Leu Lys Thr Leu Ser Gly Asp Leu Thr Thr Asn Pro Thr Ala 
                405                 410                 415     


Ala Thr Gly Asn Trp Lys Leu Thr Leu Gly Gly Ser Asp Ile Asp Ala 
            420                 425                 430         


Asp Phe Val Val Phe Asp Gly Ile Leu Tyr Ala Thr Leu Thr Pro Asn 
        435                 440                 445             


Gln Trp Ser Asp Phe Gly Pro Ala Ala Asp Ile Tyr Asp Pro Ala Gln 
    450                 455                 460                 


Val Leu Asn Pro Asp Thr Gly Leu Ala Asn Val Leu Ala Asn Phe Ala 
465                 470                 475                 480 


Asp Ala Lys Ala Glu Gly Arg Asp Thr Ile Asn Gly Gln Asn Thr Ile 
                485                 490                 495     


Arg Ile Ser Gly Lys Val Ser Ala Gln Ala Val Asn Gln Ile Ala Pro 
            500                 505                 510         


Pro Phe Asn Ala Thr Gln Pro Val Pro Ala Thr Val Trp Ile Gln Glu 
        515                 520                 525             


Thr Gly Asp His Gln Leu Ala Gln Ala Gln Leu Asp Arg Gly Ser Gly 
    530                 535                 540                 


Asn Ser Val Gln Met Thr Leu Ser Lys Trp Gly Glu Lys Val Gln Val 
545                 550                 555                 560 


Thr Lys Pro Pro Val Ser Asn Glu Leu Val Asp Thr Thr Glu Met Tyr 
                565                 570                 575     


Leu Arg Thr Ile Tyr Asp Leu Glu Glu Glu Gly Val Thr Pro Leu Arg 
            580                 585                 590         


Ala Arg Ile Ala Glu Arg Leu Asp Gln Ser Gly Pro Thr Val Ser Gln 
        595                 600                 605             


Thr Val Ser Arg Met Glu Arg Asp Gly Leu Leu Arg Val Ala Gly Asp 
    610                 615                 620                 


Arg His Leu Glu Leu Thr Glu Lys Gly Arg Ala Leu Ala Ile Ala Val 
625                 630                 635                 640 


Met Arg Lys His Arg Leu Ala Glu Arg Leu Leu Val Asp Val Ile Gly 
                645                 650                 655     


Leu Pro Trp Glu Glu Val His Ala Glu Ala Cys Arg Trp Glu His Val 
            660                 665                 670         


Met Ser Glu Asp Val Glu Arg Arg Leu Val Lys Val Leu Asn Asn Pro 
        675                 680                 685             


Thr Thr Ser Pro Phe Gly Asn Pro Ile Pro Gly Leu Val Glu Leu Gly 
    690                 695                 700                 


Val Gly Pro Glu Pro Gly Ala Asp Asp Ala Asn Leu Val Arg Leu Thr 
705                 710                 715                 720 


Glu Leu Pro Ala Gly Ser Pro Val Ala Val Val Val Arg Gln Leu Thr 
                725                 730                 735     


Glu His Val Gln Gly Asp Ile Asp Leu Ile Thr Arg Leu Lys Asp Ala 
            740                 745                 750         


Gly Val Val Pro Asn Ala Arg Val Thr Val Glu Thr Thr Pro Gly Gly 
        755                 760                 765             


Gly Val Thr Ile Val Ile Pro Gly His Glu Asn Val Thr Leu Pro His 
    770                 775                 780                 


Glu Met Ala His Ala Val Lys Val Glu Lys Val 
785                 790                 795 


<210>  47
<211>  2430
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(2430)

<400>  47
atg gcc gac gag gca cca act agt cct gat aca atg gta aca act gac         48
Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp           
1               5                   10                  15                

gtt atc aaa tct aga gta caa ttg gct tgc aga gcc cca tca tta cat         96
Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His           
            20                  25                  30                    

aat tcc caa cca tgg cgc tgg att gcc gag gat cac aca gtg gca cta        144
Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu           
        35                  40                  45                        

ttc tta gac aaa gat aga gtt ctt tat gct aca gat cat agt ggc aga        192
Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg           
    50                  55                  60                            

gaa gca ctg ctg gga tgt ggt gct gtc cta gac cac ttc aga gtt gct        240
Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala           
65                  70                  75                  80            

atg gct gcg gcg ggc acc aca gca aat gtc gaa cga ttc cca aat cct        288
Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro           
                85                  90                  95                

aac gat cca tta cat ctt gca tct att gac ttt tct cct gct gat ttt        336
Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe           
            100                 105                 110                   

gtc aca gaa ggc cac aga ttg aga gct gat gcg atc tta ttg agg aga        384
Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg           
        115                 120                 125                       

aca gat aga ttg cct ttc gct gag cct cca gac tgg gac tta gta gaa        432
Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu           
    130                 135                 140                           

tca cag ttg agg act aca gtt act gct gat acc gtt aga atc gat gtt        480
Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val           
145                 150                 155                 160           

ata gcg gat gat atg agg cca gaa ctt gca gcc gca tcc aaa ttg acc        528
Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr           
                165                 170                 175               

gaa tct ttg aga cta tac gat agc tct tac cat gcg gaa ctg ttt tgg        576
Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp           
            180                 185                 190                   

tgg act ggt gct ttc gaa aca tct gaa ggg ata cca cat tct tca tta        624
Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu           
        195                 200                 205                       

gtt tca gct gca gaa tcc gat aga gtc act ttt ggt cgt gat ttc cca        672
Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro           
    210                 215                 220                           

gtc gta gca aat act gac aga cga cct gaa ttt ggt cat gac aga tct        720
Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser           
225                 230                 235                 240           

aaa gta ctt gtt ctc agc acc tac gat aat gaa agg gct tct ttg tta        768
Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu           
                245                 250                 255               

aga tgc ggt gaa atg cta agt gcc gtc tta ctg gat gcg act atg gct        816
Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala           
            260                 265                 270                   

gga ttg gca act tgt aca ctg acc cat atc acg gaa ctg cat gca tca        864
Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser           
        275                 280                 285                       

aga gat ctc gta gca gcc ttg att ggc caa cca gcc aca cct caa gcc        912
Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala           
    290                 295                 300                           

ctt gtg aga gta gga ttg gct cca gag atg gag gaa cca cct cct gct        960
Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala           
305                 310                 315                 320           

act cca cgt aga ccc atc gac gaa gtg ttc cat gtg aga gct aag gat       1008
Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp           
                325                 330                 335               

cat aga atg aga act cca agg aga cat tgt cgt aga atc gcc gtg ctc       1056
His Arg Met Arg Thr Pro Arg Arg His Cys Arg Arg Ile Ala Val Leu           
            340                 345                 350                   

gca gca gtc agt atc gcc gca aca gtc gtt gct ggt tgc tca tct ggt       1104
Ala Ala Val Ser Ile Ala Ala Thr Val Val Ala Gly Cys Ser Ser Gly           
        355                 360                 365                       

tca aaa cca tct ggt ggc cca ctt cca gac gcc aag cct ttg gtg gaa       1152
Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp Ala Lys Pro Leu Val Glu           
    370                 375                 380                           

gag gca aca gct cag act aag gcg ttg aag tcc gca cac atg gtt cta       1200
Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys Ser Ala His Met Val Leu           
385                 390                 395                 400           

act gtt aat ggt aaa att cct ggg cta tca ctt aag aca cta tct gga       1248
Thr Val Asn Gly Lys Ile Pro Gly Leu Ser Leu Lys Thr Leu Ser Gly           
                405                 410                 415               

gat ctc act acc aat cca aca gct gct acg ggt aac tgg aaa ctt aca       1296
Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr Gly Asn Trp Lys Leu Thr           
            420                 425                 430                   

ttg gga ggt tca gac atc gat gct gac ttt gtg gta ttt gat ggt att       1344
Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe Val Val Phe Asp Gly Ile           
        435                 440                 445                       

ttg tac gct acc tta aca cca aac caa tgg tca gat ttt gga cca gcc       1392
Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp Ser Asp Phe Gly Pro Ala           
    450                 455                 460                           

gca gat atc tac gat cct gct caa gtt cta aat cca gac aca ggt tta       1440
Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu Asn Pro Asp Thr Gly Leu           
465                 470                 475                 480           

gcg aac gtt ctt gct aat ttc gct gat gct aag gcc gaa ggg aga gac       1488
Ala Asn Val Leu Ala Asn Phe Ala Asp Ala Lys Ala Glu Gly Arg Asp           
                485                 490                 495               

acc att aac ggt caa aat act att aga ata tct ggc aag gta tct gca       1536
Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile Ser Gly Lys Val Ser Ala           
            500                 505                 510                   

caa gcc gtc aac caa att gca cct cct ttt aac gct acc caa cca gtc       1584
Gln Ala Val Asn Gln Ile Ala Pro Pro Phe Asn Ala Thr Gln Pro Val           
        515                 520                 525                       

cca gct act gta tgg atc caa gag act gga gat cat cag tta gct caa       1632
Pro Ala Thr Val Trp Ile Gln Glu Thr Gly Asp His Gln Leu Ala Gln           
    530                 535                 540                           

gct caa ctg gac aga ggg agt ggc aat tcc gtt cag atg aca ctc tcc       1680
Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser Val Gln Met Thr Leu Ser           
545                 550                 555                 560           

aaa tgg ggc gag aag gtt caa gtc aca aaa cca cct gtt tca aat gaa       1728
Lys Trp Gly Glu Lys Val Gln Val Thr Lys Pro Pro Val Ser Asn Glu           
                565                 570                 575               

tta gta gac acc act gaa atg tat ctt aga aca ata tac gac tta gag       1776
Leu Val Asp Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu           
            580                 585                 590                   

gaa gag ggc gtg acc cca tta aga gcc aga atc gcc gaa aga tta gac       1824
Glu Glu Gly Val Thr Pro Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp           
        595                 600                 605                       

caa tcc ggt cca act gtt tct caa aca gtg tct agg atg gaa aga gat       1872
Gln Ser Gly Pro Thr Val Ser Gln Thr Val Ser Arg Met Glu Arg Asp           
    610                 615                 620                           

ggt ttg tta agg gtt gct gga gat cgt cac ctc gaa ctc aca gag aaa       1920
Gly Leu Leu Arg Val Ala Gly Asp Arg His Leu Glu Leu Thr Glu Lys           
625                 630                 635                 640           

ggt aga gct ttg gca atc gca gtc atg aga aag cat aga cta gcg gaa       1968
Gly Arg Ala Leu Ala Ile Ala Val Met Arg Lys His Arg Leu Ala Glu           
                645                 650                 655               

cga ttg cta gtg gac gtg atc gga ctg cct tgg gaa gag gtc cat gct       2016
Arg Leu Leu Val Asp Val Ile Gly Leu Pro Trp Glu Glu Val His Ala           
            660                 665                 670                   

gaa gca tgt aga tgg gaa cat gtt atg tct gag gat gta gag aga aga       2064
Glu Ala Cys Arg Trp Glu His Val Met Ser Glu Asp Val Glu Arg Arg           
        675                 680                 685                       

ttg gtc aaa gta ttg aat aat cca acc aca tca cct ttt gga aac cct       2112
Leu Val Lys Val Leu Asn Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro           
    690                 695                 700                           

att cct ggg cta gtt gaa ctt ggt gtg ggt cct gaa cca ggc gca gat       2160
Ile Pro Gly Leu Val Glu Leu Gly Val Gly Pro Glu Pro Gly Ala Asp           
705                 710                 715                 720           

gat gcg aat ctg gta aga ttg aca gaa tta cca gca ggg tca cca gtt       2208
Asp Ala Asn Leu Val Arg Leu Thr Glu Leu Pro Ala Gly Ser Pro Val           
                725                 730                 735               

gca gtt gtt gta aga caa ctg acg gaa cac gtg cag ggt gat att gat       2256
Ala Val Val Val Arg Gln Leu Thr Glu His Val Gln Gly Asp Ile Asp           
            740                 745                 750                   

ctt atc aca aga ttg aag gac gct ggt gtt gta cca aac gcc cgt gtc       2304
Leu Ile Thr Arg Leu Lys Asp Ala Gly Val Val Pro Asn Ala Arg Val           
        755                 760                 765                       

act gtt gaa aca act cct gga ggt ggc gtc aca att gtt ata cca ggc       2352
Thr Val Glu Thr Thr Pro Gly Gly Gly Val Thr Ile Val Ile Pro Gly           
    770                 775                 780                           

cac gaa aac gtt act ctt cca cat gaa atg gcc cat gct gta aaa gtc       2400
His Glu Asn Val Thr Leu Pro His Glu Met Ala His Ala Val Lys Val           
785                 790                 795                 800           

gag aag gtt cac cat cac cac cac cat taa                               2430
Glu Lys Val His His His His His His                                       
                805                                                       


<210>  48
<211>  809
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48

Met Ala Asp Glu Ala Pro Thr Ser Pro Asp Thr Met Val Thr Thr Asp 
1               5                   10                  15      


Val Ile Lys Ser Arg Val Gln Leu Ala Cys Arg Ala Pro Ser Leu His 
            20                  25                  30          


Asn Ser Gln Pro Trp Arg Trp Ile Ala Glu Asp His Thr Val Ala Leu 
        35                  40                  45              


Phe Leu Asp Lys Asp Arg Val Leu Tyr Ala Thr Asp His Ser Gly Arg 
    50                  55                  60                  


Glu Ala Leu Leu Gly Cys Gly Ala Val Leu Asp His Phe Arg Val Ala 
65                  70                  75                  80  


Met Ala Ala Ala Gly Thr Thr Ala Asn Val Glu Arg Phe Pro Asn Pro 
                85                  90                  95      


Asn Asp Pro Leu His Leu Ala Ser Ile Asp Phe Ser Pro Ala Asp Phe 
            100                 105                 110         


Val Thr Glu Gly His Arg Leu Arg Ala Asp Ala Ile Leu Leu Arg Arg 
        115                 120                 125             


Thr Asp Arg Leu Pro Phe Ala Glu Pro Pro Asp Trp Asp Leu Val Glu 
    130                 135                 140                 


Ser Gln Leu Arg Thr Thr Val Thr Ala Asp Thr Val Arg Ile Asp Val 
145                 150                 155                 160 


Ile Ala Asp Asp Met Arg Pro Glu Leu Ala Ala Ala Ser Lys Leu Thr 
                165                 170                 175     


Glu Ser Leu Arg Leu Tyr Asp Ser Ser Tyr His Ala Glu Leu Phe Trp 
            180                 185                 190         


Trp Thr Gly Ala Phe Glu Thr Ser Glu Gly Ile Pro His Ser Ser Leu 
        195                 200                 205             


Val Ser Ala Ala Glu Ser Asp Arg Val Thr Phe Gly Arg Asp Phe Pro 
    210                 215                 220                 


Val Val Ala Asn Thr Asp Arg Arg Pro Glu Phe Gly His Asp Arg Ser 
225                 230                 235                 240 


Lys Val Leu Val Leu Ser Thr Tyr Asp Asn Glu Arg Ala Ser Leu Leu 
                245                 250                 255     


Arg Cys Gly Glu Met Leu Ser Ala Val Leu Leu Asp Ala Thr Met Ala 
            260                 265                 270         


Gly Leu Ala Thr Cys Thr Leu Thr His Ile Thr Glu Leu His Ala Ser 
        275                 280                 285             


Arg Asp Leu Val Ala Ala Leu Ile Gly Gln Pro Ala Thr Pro Gln Ala 
    290                 295                 300                 


Leu Val Arg Val Gly Leu Ala Pro Glu Met Glu Glu Pro Pro Pro Ala 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Ile Asp Glu Val Phe His Val Arg Ala Lys Asp 
                325                 330                 335     


His Arg Met Arg Thr Pro Arg Arg His Cys Arg Arg Ile Ala Val Leu 
            340                 345                 350         


Ala Ala Val Ser Ile Ala Ala Thr Val Val Ala Gly Cys Ser Ser Gly 
        355                 360                 365             


Ser Lys Pro Ser Gly Gly Pro Leu Pro Asp Ala Lys Pro Leu Val Glu 
    370                 375                 380                 


Glu Ala Thr Ala Gln Thr Lys Ala Leu Lys Ser Ala His Met Val Leu 
385                 390                 395                 400 


Thr Val Asn Gly Lys Ile Pro Gly Leu Ser Leu Lys Thr Leu Ser Gly 
                405                 410                 415     


Asp Leu Thr Thr Asn Pro Thr Ala Ala Thr Gly Asn Trp Lys Leu Thr 
            420                 425                 430         


Leu Gly Gly Ser Asp Ile Asp Ala Asp Phe Val Val Phe Asp Gly Ile 
        435                 440                 445             


Leu Tyr Ala Thr Leu Thr Pro Asn Gln Trp Ser Asp Phe Gly Pro Ala 
    450                 455                 460                 


Ala Asp Ile Tyr Asp Pro Ala Gln Val Leu Asn Pro Asp Thr Gly Leu 
465                 470                 475                 480 


Ala Asn Val Leu Ala Asn Phe Ala Asp Ala Lys Ala Glu Gly Arg Asp 
                485                 490                 495     


Thr Ile Asn Gly Gln Asn Thr Ile Arg Ile Ser Gly Lys Val Ser Ala 
            500                 505                 510         


Gln Ala Val Asn Gln Ile Ala Pro Pro Phe Asn Ala Thr Gln Pro Val 
        515                 520                 525             


Pro Ala Thr Val Trp Ile Gln Glu Thr Gly Asp His Gln Leu Ala Gln 
    530                 535                 540                 


Ala Gln Leu Asp Arg Gly Ser Gly Asn Ser Val Gln Met Thr Leu Ser 
545                 550                 555                 560 


Lys Trp Gly Glu Lys Val Gln Val Thr Lys Pro Pro Val Ser Asn Glu 
                565                 570                 575     


Leu Val Asp Thr Thr Glu Met Tyr Leu Arg Thr Ile Tyr Asp Leu Glu 
            580                 585                 590         


Glu Glu Gly Val Thr Pro Leu Arg Ala Arg Ile Ala Glu Arg Leu Asp 
        595                 600                 605             


Gln Ser Gly Pro Thr Val Ser Gln Thr Val Ser Arg Met Glu Arg Asp 
    610                 615                 620                 


Gly Leu Leu Arg Val Ala Gly Asp Arg His Leu Glu Leu Thr Glu Lys 
625                 630                 635                 640 


Gly Arg Ala Leu Ala Ile Ala Val Met Arg Lys His Arg Leu Ala Glu 
                645                 650                 655     


Arg Leu Leu Val Asp Val Ile Gly Leu Pro Trp Glu Glu Val His Ala 
            660                 665                 670         


Glu Ala Cys Arg Trp Glu His Val Met Ser Glu Asp Val Glu Arg Arg 
        675                 680                 685             


Leu Val Lys Val Leu Asn Asn Pro Thr Thr Ser Pro Phe Gly Asn Pro 
    690                 695                 700                 


Ile Pro Gly Leu Val Glu Leu Gly Val Gly Pro Glu Pro Gly Ala Asp 
705                 710                 715                 720 


Asp Ala Asn Leu Val Arg Leu Thr Glu Leu Pro Ala Gly Ser Pro Val 
                725                 730                 735     


Ala Val Val Val Arg Gln Leu Thr Glu His Val Gln Gly Asp Ile Asp 
            740                 745                 750         


Leu Ile Thr Arg Leu Lys Asp Ala Gly Val Val Pro Asn Ala Arg Val 
        755                 760                 765             


Thr Val Glu Thr Thr Pro Gly Gly Gly Val Thr Ile Val Ile Pro Gly 
    770                 775                 780                 


His Glu Asn Val Thr Leu Pro His Glu Met Ala His Ala Val Lys Val 
785                 790                 795                 800 


Glu Lys Val His His His His His His 
                805                 


