                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
 
<120>  Engineered primate cystine/cysteine degrading enzymes as 
       antineogenic agents

<130>  UTFB.P1017WO

<150>  US 61/871,727
<151>  2013-08-29

<150>  US 61/948,106
<151>  2014-03-05

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  2
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Thr Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  3
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Gln Glu Lys Glu Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Pro Ser Val Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Thr Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Ala Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Met Thr Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu Tyr Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Val Met Thr His Ala Ser Val Leu Lys Lys Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  4
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Leu Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Ala Ala Pro Gly Gln His Ser Gly Phe Thr Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Val Leu Lys Met Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Arg Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Leu Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Gly Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Ile Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Pro Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Lys 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Asn 
                405 


<210>  5
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Thr Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  6
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Lys Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Thr Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Ile Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Val Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  7
<211>  405
<212>  PRT
<213>  Pongo abelii

<400>  7

Met Gln Glu Lys Glu Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Pro Ile Ser Pro Ser Val Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Val Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Ala Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Met Thr Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu Tyr Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu Gln Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Val Met Thr His Ala Ser Val Leu Lys Lys Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  8
<211>  405
<212>  PRT
<213>  Macaca fascicularis

<400>  8

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Glu Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Val Val Pro Leu Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Ala Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Val Leu Lys Met Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys Arg Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Arg Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Leu Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Gly Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Ile Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Val Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Pro Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Lys 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Asn 
                405 


<210>  9
<211>  405
<212>  PRT
<213>  Pan troglodytes

<400>  9

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Arg Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  10
<211>  405
<212>  PRT
<213>  Pan paniscus

<400>  10

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Thr Ser Lys Ala Leu Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                85                  90                  95      


Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
145                 150                 155                 160 


Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Ala Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Tyr 
        195                 200                 205             


Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Ile Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210>  11
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Gly Gly His His His His His His Gly Gly Gln Glu Lys Asp Ala 
1               5                   10                  15      


Ser Ser Gln Gly Phe Leu Pro His Phe Gln His Phe Ala Thr Gln Ala 
            20                  25                  30          


Ile His Val Gly Gln Asp Pro Glu Gln Trp Thr Ser Arg Ala Val Val 
        35                  40                  45              


Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys Gln Gly Ala Pro Gly Gln 
    50                  55                  60                  


His Ser Gly Phe Thr Tyr Ser Arg Ser Gly Asn Pro Thr Arg Asn Cys 
65                  70                  75                  80  


Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala Lys Tyr Cys Leu Ala 
                85                  90                  95      


Phe Ala Ser Gly Leu Ala Ala Thr Val Thr Ile Thr His Leu Leu Lys 
            100                 105                 110         


Ala Gly Asp Gln Ile Ile Cys Met Asp Asp Val Tyr Gly Gly Thr Asn 
        115                 120                 125             


Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe Gly Leu Lys Ile Ser Phe 
    130                 135                 140                 


Val Asp Cys Ser Lys Ile Lys Leu Leu Glu Ala Ala Ile Thr Pro Glu 
145                 150                 155                 160 


Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn Pro Thr Gln Lys Val 
                165                 170                 175     


Ile Asp Ile Glu Gly Cys Ala His Ile Val His Lys His Gly Asp Ile 
            180                 185                 190         


Ile Leu Val Val Asp Asn Thr Phe Met Ser Pro Tyr Phe Gln Arg Pro 
        195                 200                 205             


Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr Ser Ala Thr Lys Tyr Met 
    210                 215                 220                 


Asn Gly His Ser Asp Val Val Met Gly Leu Val Ser Val Asn Cys Glu 
225                 230                 235                 240 


Ser Leu His Asn Arg Leu Arg Phe Leu Gln Asn Ser Leu Gly Ala Val 
                245                 250                 255     


Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn Arg Gly Leu Lys Thr Leu 
            260                 265                 270         


His Val Arg Met Glu Lys His Phe Lys Asn Gly Met Ala Val Ala Gln 
        275                 280                 285             


Phe Leu Glu Ser Asn Pro Trp Val Glu Lys Val Ile Tyr Pro Gly Leu 
    290                 295                 300                 


Pro Ser His Pro Gln His Glu Leu Val Lys Arg Gln Cys Thr Gly Cys 
305                 310                 315                 320 


Thr Gly Met Val Thr Phe Tyr Ile Lys Gly Thr Leu Gln His Ala Glu 
                325                 330                 335     


Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr Leu Ala Val Ser Leu Gly 
            340                 345                 350         


Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala Ile Met Thr His Ala Ser 
        355                 360                 365             


Val Leu Lys Asn Asp Arg Asp Val Leu Gly Ile Ser Asp Thr Leu Ile 
    370                 375                 380                 


Arg Leu Ser Val Gly Leu Glu Asp Glu Glu Asp Leu Leu Glu Asp Leu 
385                 390                 395                 400 


Asp Gln Ala Leu Lys Ala Ala His Pro Pro Ser Gly Ser His Ser 
                405                 410                 415 


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  s is c or g

<400>  12
ggccagcata gcggttttnn statagccgt agcggc                                 36


<210>  13
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  13
gccgctacgg ctatasnnaa aaccgctatg ctggcc                                 36


<210>  14
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  s is c or g

<400>  14
gtatggtggg accaatnnst atttccgtca ggtggcg                                37


<210>  15
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  15
cgccacctga cggaaatasn nattggtccc accatac                                37


<210>  16
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  s is c or g

<400>  16
ctgaaactgt ttaccctggc annsagcttg ggcggctttg                             40


<210>  17
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  17
caaagccgcc caagctsnnt gccagggtaa acagtttcag                             40


<210>  18
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gatataccat gggaggccat caccaccatc atcatggcgg gcaggaaaag gatgcg           56


<210>  19
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
ctcgaattct caactgtggc ttcccgatgg gggatgggcc gctttcagcg cctgatcc         58


