                         SEQUENCE LISTING

<110>  Gilupi GmbH
 
<120>  Diagnostic device for the detection of disease related target structures

<130>  PCT86535HVTR

<140>  not yet assigned
<141>  herewith

<150>  EP 13 181 879.1
<151>  2013-08-27

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1321
<212>  PRT
<213>  Tetraodon nigroviridis

<400>  1

Met Ile Lys Ile Leu Ile Ser Leu Leu Cys Cys Ala Val Leu Phe Thr 
1               5                   10                  15      


Val Gly Ile Leu Ile Gly His Tyr Ala Ile Pro Arg Ser Ser Thr Pro 
            20                  25                  30          


Pro Pro Ser Trp Leu Thr Glu Val Ala Lys Asp Val Asp Glu Ser Phe 
        35                  40                  45              


Ile Glu Ala Phe Leu Ser Glu Val Asn Asn Leu Gln Ile Gln Glu Asn 
    50                  55                  60                  


Leu Lys Glu Leu Thr Lys Ala Pro His Met Ala Thr Thr Pro Gly Asp 
65                  70                  75                  80  


Glu Asp Thr Val Asn Tyr Met Leu Lys Arg Trp Gln Asp Pro Asp Ser 
                85                  90                  95      


Gly Leu Asp Gln Ala Trp Arg Glu Glu Tyr Met Val Tyr Leu Ser Phe 
            100                 105                 110         


Pro Asp Pro Gln Asn Pro Asn Lys Val Thr Val Val Asn Ser Ser Gly 
        115                 120                 125             


Glu Val Leu His Thr Val Arg Glu Lys Glu Lys Asn Tyr Thr Ser Asp 
    130                 135                 140                 


Gln Asn Asp Pro Glu Val Val Gln Pro Tyr Ala Ala Tyr Ser Pro Pro 
145                 150                 155                 160 


Gly Thr Pro Lys Gly Lys Leu Val Tyr Ala Asn Gln Gly Lys Pro Ser 
                165                 170                 175     


Asp Tyr Gln Gln Leu Val Asn Gln Gly Val Asp Leu Arg Asn Thr Ile 
            180                 185                 190         


Ala Ile Thr Arg Tyr Gly Gly Ala Gly Arg Ala Ala Lys Ala Ile Asn 
        195                 200                 205             


Ala Ala Pro Tyr Gly Val Val Gly Val Leu Val Tyr Thr Asp Pro Leu 
    210                 215                 220                 


Asp Ile Asn Asp Asp Leu Met Ser Asp Phe Asn Glu Thr Tyr Pro His 
225                 230                 235                 240 


Ser Trp Tyr Met Pro Pro Ser Gly Val Glu Arg Gly Ser Phe Ala Thr 
                245                 250                 255     


Asn Tyr Gly Asp Pro Leu Thr Pro Tyr Leu Ala Ala Lys Glu Gly Thr 
            260                 265                 270         


Tyr Arg Ile Ser Pro Glu Asn Ile Thr Gly Ile Pro Pro Ile Pro Ile 
        275                 280                 285             


Gln Pro Ile Gly Phe Glu Asp Ala Tyr Met Leu Ile Trp Phe Val Met 
    290                 295                 300                 


Ala Gln Leu Asp Gly Asp Lys Ala Pro Val Asp Trp Gln Gly Ser Phe 
305                 310                 315                 320 


Asn Cys Ser Tyr Asn Phe Gly Gly Pro Gly Phe Lys Asn Thr Ser Ala 
                325                 330                 335     


Phe Ser Gly Ser Asp Val Gln Leu Asn Ile Ser Asn Tyr Gly Glu Ile 
            340                 345                 350         


Arg Asn Ser Ser Asn Val Met Gly Val Ile Arg Gly Ser Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Tyr Gly Asn His Arg Asp Ser Trp Val His Gly 
    370                 375                 380                 


Ala Ile Asp Pro Ser Ser Gly Thr Ser Val Met Leu Glu Leu Ser Arg 
385                 390                 395                 400 


Val Leu Gly Ala Lys Val Lys Gln Gly Lys Trp Arg Pro Arg Arg Ser 
                405                 410                 415     


Ile Ile Phe Gly Ser Trp Gly Ala Glu Glu Phe Gly Leu Ile Gly Ser 
            420                 425                 430         


Ala Glu Tyr Thr Glu Gln Tyr Leu Pro Lys Leu Ser Gln Arg Thr Val 
        435                 440                 445             


Ala Tyr Ile Asn Val Asp Ile Ala Val Phe Ala Asn Ala Thr Leu Arg 
    450                 455                 460                 


Ala Ser Gly Met Pro Ser Val Gln Asn Val Ile Phe Lys Ala Ala Lys 
465                 470                 475                 480 


Gln Val Asn Ala Pro Gly Val Asp Ser Thr Ser Val Tyr Glu Asn Trp 
                485                 490                 495     


Met Lys Tyr Ser Asn Arg Thr Ser Pro Glu His Gly Thr Ile Pro Arg 
            500                 505                 510         


Met Gly Tyr Trp Ile Gly Gln Glu Val Ile Thr Leu Pro Ser Ser Ile 
        515                 520                 525             


Thr Trp Glu Ser Gln Pro Trp Thr Cys Pro Thr Arg Met Thr Gly Val 
    530                 535                 540                 


Lys Gln Arg Ser His Leu Arg Cys Leu Pro His Gly Leu Arg His Arg 
545                 550                 555                 560 


Arg Leu Leu Leu Gln Val Ile Asp Pro Gly Phe Val Ser His Gln Ala 
                565                 570                 575     


Val Ala Arg Thr Ala Gly Asn Ala Leu Ile Arg Leu Ala Asp Ser Leu 
            580                 585                 590         


Val Leu Pro Leu Asn Cys Ser Asp Tyr Ala Glu Gly Leu Glu Asp Tyr 
        595                 600                 605             


Leu Arg Thr Ala Val Gly Leu Tyr Glu Gly Gln Leu Gln Met Trp Asn 
    610                 615                 620                 


Ile Ser Met Gly Asn Pro Val Thr His Ala Leu Ile Arg Asn Asn Ala 
625                 630                 635                 640 


Glu Arg Glu Tyr Ser Lys Thr Lys Thr Thr Phe Cys Phe Val Phe Thr 
                645                 650                 655     


Glu Pro Leu Lys Ser Ala Val Ala Asn Phe Arg Lys Ala Ala Thr Arg 
            660                 665                 670         


Met Asp Arg Thr Ile His Ser Leu Asp Leu Ala Asn Glu Thr Pro Leu 
        675                 680                 685             


Lys Val Arg Lys Ile Asn Asp Gln Leu Met Leu Leu Asp Arg Ala Phe 
    690                 695                 700                 


Leu Asp Pro Leu Ala Phe Pro Asp Lys Tyr Ala Phe Arg His Val Ile 
705                 710                 715                 720 


Trp Ala Ser Ser Ser Ala Gly Lys Leu Thr Phe Pro Gly Leu Ala Asp 
                725                 730                 735     


Ala Phe Ala Ser Ala Asn Asn Ser Leu Gly Glu Pro Ser Ala Gln His 
            740                 745                 750         


Lys Val His Tyr His Leu Ser Val Leu Ser Gln Ala Ile Asp Ser Ala 
        755                 760                 765             


Ala Asn Thr Leu Asp Glu Ala Pro Gly Arg Cys Ala Asp Ala Ile Asn 
    770                 775                 780                 


Ala Ala Pro Tyr Gly Val Val Gly Val Leu Val Tyr Thr Asp Pro Leu 
785                 790                 795                 800 


Asp Ile Asn Asp Ser Leu Met Ser Asp Phe Asn Glu Thr Tyr Pro His 
                805                 810                 815     


Ser Trp Tyr Met Pro Pro Ser Gly Val Glu Arg Gly Ser Phe Ala Thr 
            820                 825                 830         


Asn Tyr Gly Asp Pro Leu Thr Pro Tyr Leu Ala Ala Lys Glu Gly Thr 
        835                 840                 845             


Tyr Arg Ile Ser Pro Glu Asn Ile Thr Gly Ile Pro Pro Ile Pro Ile 
    850                 855                 860                 


Gln Pro Ile Gly Phe Glu Asp Ala Tyr Met Leu Ile Trp Phe Val Met 
865                 870                 875                 880 


Ala Gln Leu Asp Gly Asp Lys Ala Pro Val Asp Trp Gln Gly Ser Phe 
                885                 890                 895     


Asn Cys Ser Tyr Asn Phe Gly Gly Pro Gly Phe Lys Asn Thr Ser Ala 
            900                 905                 910         


Phe Ser Gly Ser Asp Val Gln Leu Asn Ile Ser Asn Tyr Gly Glu Ile 
        915                 920                 925             


Arg Asn Ser Ser Asn Val Met Gly Val Ile Arg Gly Ser Val Glu Pro 
    930                 935                 940                 


Asp Arg Tyr Val Ile Tyr Gly Asn His Arg Asp Ser Trp Val His Gly 
945                 950                 955                 960 


Ala Ile Asp Pro Ser Ser Gly Thr Ser Val Met Leu Glu Leu Ser Arg 
                965                 970                 975     


Val Leu Gly Ala Lys Gln Tyr Leu Pro Lys Leu Ser Gln Arg Thr Val 
            980                 985                 990         


Ala Tyr Ile Asn Val Asp Ile Ala  Val Phe Ala Asn Ala  Thr Leu Arg 
        995                 1000                 1005             


Ala Ser  Gly Met Pro Ser Val  Gln Asn Val Ile Phe  Lys Ala Ala 
    1010                 1015                 1020             


Lys Gln  Val Asn Ala Pro Gly  Val Asp Ser Thr Ser  Val Tyr Glu 
    1025                 1030                 1035             


Asn Trp  Met Lys Tyr Ser Asn  Arg Thr Ser Pro Glu  His Gly Thr 
    1040                 1045                 1050             


Ile Pro  Arg Met Gly Tyr Leu  Asn Gly Ala Gly Ser  Asp Tyr Ala 
    1055                 1060                 1065             


Ala Phe  Val His Tyr Leu Gly  Ile Thr Ala Met Asp  Leu Ser Tyr 
    1070                 1075                 1080             


Thr Tyr  Asp Arg Ser Lys Thr  Asn Ala Arg Ile Tyr  Pro Ala Tyr 
    1085                 1090                 1095             


His Thr  Ala Tyr Asp Thr Phe  Asp Tyr Cys Ser Lys  Tyr Ile Asp 
    1100                 1105                 1110             


Pro Gly  Phe Val Ser His Gln  Ala Val Ala Arg Thr  Ala Gly Asn 
    1115                 1120                 1125             


Ala Leu  Ile Arg Leu Ala Asp  Ser Leu Val Leu Pro  Leu Asn Cys 
    1130                 1135                 1140             


Ser Asp  Tyr Ala Glu Gly Leu  Glu Asp Tyr Leu Arg  Thr Ala Val 
    1145                 1150                 1155             


Gly Leu  Tyr Glu Gly Gln Leu  Gln Met Trp Asn Ile  Ser Met Gly 
    1160                 1165                 1170             


Asn Pro  Val Thr His Ala Leu  Ile Arg Asn Asn Ala  Glu Arg Glu 
    1175                 1180                 1185             


Tyr Ser  Lys Thr Lys Thr Thr  Phe Cys Phe Val Phe  Thr Glu Pro 
    1190                 1195                 1200             


Leu Lys  Ser Ala Val Ala Asn  Phe Arg Lys Ala Ala  Thr Arg Met 
    1205                 1210                 1215             


Asp Arg  Thr Ile His Ser Leu  Asp Leu Ala Asn Glu  Thr Pro Leu 
    1220                 1225                 1230             


Lys Val  Arg Lys Ile Asn Asp  Gln Leu Met Leu Leu  Asp Arg Ala 
    1235                 1240                 1245             


Phe Leu  Asp Pro Leu Ala Phe  Pro Asp Lys Tyr Ala  Phe Arg His 
    1250                 1255                 1260             


Val Ile  Trp Ala Ser Ser Ser  Ala Gly Lys Ser Thr  Phe Pro Gly 
    1265                 1270                 1275             


Leu Ala  Asp Ala Phe Ala Ser  Ala Asn Asn Ser Leu  Gly Glu Pro 
    1280                 1285                 1290             


Ser Ala  Gln His Lys Val His  Tyr His Leu Ser Val  Leu Ser Gln 
    1295                 1300                 1305             


Ala Ile  Asp Ser Ala Ala Asn  Thr Leu Asp Glu Val  Ile 
    1310                 1315                 1320     


<210>  2
<211>  3966
<212>  DNA
<213>  Tetraodon nigroviridis

<400>  2
atgataaaga ttttgatctc gctgctgtgc tgcgctgttc tttttacagt gggcatcttg       60

attggccact atgccatccc cagaagcagc accccgccgc cgtcctggct gacagaggtg      120

gccaaggatg tggacgagag cttcatcgag gcctttttat ctgaggtgaa caacctgcaa      180

atccaggaaa acctgaagga gctgacaaaa gcgccccaca tggccacgac acccggagac      240

gaagacacgg taaattacat gctgaagagg tggcaggatc ctgattcggg tctggaccag      300

gcctggaggg aggaatacat ggtctacttg tccttccccg atccccaaaa ccccaacaag      360

gtcacagtgg tgaactcgtc tggggaggtc ttgcacactg tcagagagaa agagaagaac      420

tacacctcag accaaaatga cccagaggtg gttcagccct acgctgcata ctcgcccccc      480

ggaacgccaa agggtaaact agtgtacgcc aaccagggga aacccagtga ctaccagcag      540

ctggtcaacc agggagtgga cctgagaaac accatcgcca tcaccagata cggaggagca      600

gggcgagctg ctaaagcgat caatgcggcc ccctacggtg tcgtgggcgt gctcgtctac      660

accgaccctt tagacatcaa cgacgatctg atgtcggact tcaatgagac gtatcctcac      720

tcctggtaca tgccgccatc tggtgtggag agaggcagtt tcgccaccaa ctacggagac      780

ccgctgaccc cctacctggc tgccaaagag ggaacgtaca gaatttcacc tgagaacatc      840

acgggtatcc ctcccattcc gatccagcca atcggattcg aggacgccta catgctcatt      900

tggtttgtga tggcccagct ggatggagac aaggctccgg tcgactggca gggttcattt      960

aactgctcct acaactttgg cggccctgga tttaaaaaca catctgcgtt cagtggaagt     1020

gacgtgcagc taaacatctc caactacggg gaaataagga actcctctaa cgtgatgggt     1080

gttatcagag ggagtgtcga gccagacagg tacgtgatct acggcaacca cagggacagc     1140

tgggtgcacg gcgccatcga ccccagcagc gggacatcgg tgatgctgga gctgagcaga     1200

gtgttgggtg ccaaggtcaa gcagggaaaa tggaggccgc gccggtcaat catcttcgga     1260

agctgggggg ctgaggagtt tggtctgatc ggttctgcag aatacacaga gcaatattta     1320

cccaaactca gccaacggac ggttgcctac atcaacgtgg acatagctgt ctttgccaac     1380

gccaccctca gagcctcggg gatgccgtcg gtgcagaacg tcatcttcaa agccgcaaaa     1440

caggttaacg cccccggagt ggattcaacg tctgtgtatg aaaactggat gaaatattcc     1500

aacaggacca gcccggagca cgggaccatt cccaggatgg gatactggat tgggcaggaa     1560

gtgattacgc tgccttcgtc cattacctgg gaatcacagc catggacctg tcctacacgt     1620

atgacaggag taaaacaacg ctcgcatcta cgctgcctac cacacggcct acgacaccgt     1680

cgactactgc tccaagtaat cgatcctggg ttcgtcagtc accaggccgt ggccaggacg     1740

gcagggaacg ccctgatccg gctggccgac agcctggtgc tgccgctgaa ctgcagcgac     1800

tacgccgagg gtctggagga ctacctgagg accgccgtgg gcctgtatga gggtcagctg     1860

cagatgtgga acatctccat gggtaaccct gtcacgcacg ccctgattag aaacaatgct     1920

gaaagagaat attcaaaaac aaaaacaacc ttctgctttg tctttacaga acctcttaaa     1980

agtgcggtgg ccaactttcg taaggccgcc actcgtatgg accggacgat ccacagtttg     2040

gacctggcaa atgagacccc actgaaggtc agaaagatca acgaccagct gatgctgctg     2100

gaccgagctt tcttggaccc tctggccttt cctgacaaat atgcattcag gcacgttatc     2160

tgggcttcca gtagtgccgg taagctgacc tttccgggtt tggccgatgc cttcgccagt     2220

gctaacaact cactgggaga gcccagcgcc cagcacaagg tgcactacca cctgtcagtg     2280

ctgagccagg ccatcgacag cgccgccaac accctggatg aggcaccagg aagatgcgct     2340

gacgcgatca atgcggcccc ctacggtgtc gtgggcgtgc tcgtctacac cgacccttta     2400

gacatcaacg acagtctgat gtcggacttc aatgagacgt atcctcactc ctggtacatg     2460

ccgccatctg gtgtggagag aggcagtttc gccaccaact acggagaccc gctgaccccc     2520

tacctggctg ccaaagaggg aacgtacaga atttcacctg agaacatcac gggtatccct     2580

cccattccga tccagccaat cggattcgag gacgcctaca tgctcatttg gtttgtgatg     2640

gcccagctgg atggagacaa ggctccggtc gactggcagg gttcatttaa ctgctcctac     2700

aactttggcg gccctggatt taaaaacaca tctgcgttca gtggaagtga cgtgcagcta     2760

aacatctcca actacgggga aataaggaac tcctctaacg tgatgggtgt tatcagaggg     2820

agtgtcgagc cagacaggta cgtgatctac ggcaaccaca gggacagctg ggtgcacggc     2880

gccatcgacc ccagcagcgg gacatcggtg atgctggagc tgagcagagt gttgggtgcc     2940

aagcaatatt tacccaaact cagccaacgg acggttgcct acatcaacgt ggacatagct     3000

gtctttgcca acgccaccct cagagcctcg gggatgccgt cggtgcagaa cgtcatcttc     3060

aaagccgcaa aacaggttaa cgcccccgga gtggattcaa cgtctgtgta tgaaaactgg     3120

atgaaatatt ccaacaggac cagcccggag cacgggacca ttcccaggat gggatacctg     3180

aatggagcag gaagtgatta cgctgccttc gtccattacc tgggaatcac agccatggac     3240

ctgtcctaca cgtatgacag gagtaaaacc aacgctcgca tctaccctgc ctaccacacg     3300

gcctacgaca ccttcgacta ctgctccaag tacatcgatc ctgggttcgt cagtcaccag     3360

gccgtggcca ggacggcagg gaacgccctg atccggctgg ccgacagcct ggtgctgccg     3420

ctgaactgca gcgactacgc cgagggtctg gaggactacc tgaggaccgc cgtgggcctg     3480

tatgagggtc agctgcagat gtggaacatc tccatgggta accctgtcac gcacgccctg     3540

attagaaaca atgctgaaag agaatattca aaaacaaaaa caaccttctg ctttgtcttt     3600

acagaacctc ttaaaagtgc ggtggccaac tttcgtaagg ccgccactcg tatggaccgg     3660

acgatccaca gtttggacct ggcaaatgag accccactga aggtcagaaa gatcaacgac     3720

cagctgatgc tgctggaccg agctttcttg gaccctctgg cctttcctga caaatatgca     3780

ttcaggcacg ttatctgggc ttccagtagt gccggtaagt cgacctttcc gggtttggcc     3840

gatgccttcg ccagtgctaa caactcactg ggagagccca gcgcccagca caaggtgcac     3900

taccacctgt cagtgctgag ccaggccatc gacagcgccg ccaacaccct ggatgaggtc     3960

atatag                                                                3966


