                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
 
<120>  ANTIBODIES

<130>  G0181-PCT

<150>  GB1315487.7
<151>  2013-08-30

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDR-L1

<400>  1

Leu Ala Ser Glu Asp Ile Tyr Asp Asn Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDRL2

<400>  2

Tyr Ala Ser Ser Leu Gln Asp 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDR-L3

<400>  3

Leu Gln Asp Ser Glu Tyr Pro Trp Thr 
1               5                   


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDR-H1

<400>  4

Gly Phe Ser Leu Thr Thr Tyr Gly Met Gly Val Gly 
1               5                   10          


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDR-H2

<400>  5

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA019_969 Ab sequences CDR-H3

<400>  6

Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro Tyr Arg Tyr Phe Asp Phe 
1               5                   10                  15      


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VL region

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Ser Pro His Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VL region

<400>  8
gacatccaga tgacacagtc tccagcttcc ctgtctgcat ctctgggaga aactgtctcc       60

atcgaatgtc tagcaagtga ggacatttac gataatttag cgtggtacca gaagaagcca      120

ggaaaatctc ctcacctcct catctattat gcaagtagct tgcaagatgg ggtcccatca      180

cggttcagtg gcagtggatc tggcacacag tattctctca aaatcaacag cctggaatct      240

gaagatgctg cgacttattt ctgtctacag gattctgagt atccgtggac gttcggtgga      300

ggcaccaagc tggaattgaa a                                                321


<210>  9
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VL region with signal sequence underlined and 
       italicised

<400>  9

Met Gly Val Pro Thr Gln Leu Leu Val Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Ala Ile Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Asn Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


His Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Ala Ala Thr Tyr Phe Cys Leu Gln Asp Ser 
            100                 105                 110         


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  10
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VL region with signal sequence underlined and 
       italicised

<400>  10
atgggtgtcc ccactcagct cttggtgttg ttgctgctgt ggattacaga tgccatatgt       60

gacatccaga tgacacagtc tccagcttcc ctgtctgcat ctctgggaga aactgtctcc      120

atcgaatgtc tagcaagtga ggacatttac gataatttag cgtggtacca gaagaagcca      180

ggaaaatctc ctcacctcct catctattat gcaagtagct tgcaagatgg ggtcccatca      240

cggttcagtg gcagtggatc tggcacacag tattctctca aaatcaacag cctggaatct      300

gaagatgctg cgacttattt ctgtctacag gattctgagt atccgtggac gttcggtgga      360

ggcaccaagc tggaattgaa a                                                381


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VH region

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Leu Thr Asn Val His Thr Ser Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro Tyr Arg Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser 
        115                 120                 125 


<210>  12
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VH region

<400>  12
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgcactt tctctgggtt ttcactgacc acttatggta tgggtgtggg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcaaacattt ggtgggatga tgataagtat      180

tacaatccat ctctgaaaaa ccggctcaca atctccaagg acacctccaa caaccaagca      240

ttcctcaagc tcaccaatgt acacacttca gattctgcca catactactg tgctcggata      300

gggccgatta aatacccgac ggccccctac cggtactttg acttctgggg cccaggaacc      360

atggtcaccg tctcg                                                       375


<210>  13
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VH region with signal sequence underlined and 
       italicised

<400>  13

Met Asp Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn 
                85                  90                  95      


Asn Gln Ala Phe Leu Lys Leu Thr Asn Val His Thr Ser Asp Ser Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro 
        115                 120                 125             


Tyr Arg Tyr Phe Asp Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


<210>  14
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 969 VH region with signal sequence underlined and 
       italicised

<400>  14
atggacaggc ttacttcctc attcctactg ctgattgtcc ctgcatatgt cctgtctcag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgcactttct ctgggttttc actgaccact tatggtatgg gtgtgggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctggca aacatttggt gggatgatga taagtattac      240

aatccatctc tgaaaaaccg gctcacaatc tccaaggaca cctccaacaa ccaagcattc      300

ctcaagctca ccaatgtaca cacttcagat tctgccacat actactgtgc tcggataggg      360

ccgattaaat acccgacggc cccctaccgg tactttgact tctggggccc aggaaccatg      420

gtcaccgtct cg                                                          432


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gL7 V-region

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gL7 V-region

<400>  16
gacatacaga tgactcagtc accctcaagc ctgagtgcca gtgtgggaga cagggtgaca       60

atcacctgtc tggcctccga ggatatctac gataacctgg catggtatca gcagaaacct      120

ggaaaggctc ccaagctcct gatttattat gcctcctctc tccaagacgg cgttccatct      180

cggttcagcg gaagcggctc cgggacggat tacacactga caattagctc tctgcaaccg      240

gaggattttg ctacttacta ctgcctgcaa gactccgaat acccatggac cttcggtggt      300

ggcaccaaag tggaaatcaa g                                                321


<210>  17
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gL7 V-region with signal sequence underlined and italicized

<400>  17

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser 
            100                 105                 110         


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         


<210>  18
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gL7 V-region with signal sequence underlined and italicized

<400>  18
atgagcgtgc ctactcaagt cttggggctg ctcttgcttt ggcttaccga cgcaagatgc       60

gacatacaga tgactcagtc accctcaagc ctgagtgcca gtgtgggaga cagggtgaca      120

atcacctgtc tggcctccga ggatatctac gataacctgg catggtatca gcagaaacct      180

ggaaaggctc ccaagctcct gatttattat gcctcctctc tccaagacgg cgttccatct      240

cggttcagcg gaagcggctc cgggacggat tacacactga caattagctc tctgcaaccg      300

gaggattttg ctacttacta ctgcctgcaa gactccgaat acccatggac cttcggtggt      360

ggcaccaaag tggaaatcaa g                                                381


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gL7 light chain (V + constant)

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gL7 light chain (V + constant)

<400>  20
gacatacaga tgactcagtc accctcaagc ctgagtgcca gtgtgggaga cagggtgaca       60

atcacctgtc tggcctccga ggatatctac gataacctgg catggtatca gcagaaacct      120

ggaaaggctc ccaagctcct gatttattat gcctcctctc tccaagacgg cgttccatct      180

cggttcagcg gaagcggctc cgggacggat tacacactga caattagctc tctgcaaccg      240

gaggattttg ctacttacta ctgcctgcaa gactccgaat acccatggac cttcggtggt      300

ggcaccaaag tggaaatcaa gcgtacggta gcggccccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  21
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gL7 light chain (V + constant) with signal sequence 
       underlined and italicized

<400>  21

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser 
            100                 105                 110         


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  22
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gL7 light chain (V + constant) with signal sequence 
       underlined and italicized

<400>  22
atgagcgtgc ctactcaagt cttggggctg ctcttgcttt ggcttaccga cgcaagatgc       60

gacatacaga tgactcagtc accctcaagc ctgagtgcca gtgtgggaga cagggtgaca      120

atcacctgtc tggcctccga ggatatctac gataacctgg catggtatca gcagaaacct      180

ggaaaggctc ccaagctcct gatttattat gcctcctctc tccaagacgg cgttccatct      240

cggttcagcg gaagcggctc cgggacggat tacacactga caattagctc tctgcaaccg      300

gaggattttg ctacttacta ctgcctgcaa gactccgaat acccatggac cttcggtggt      360

ggcaccaaag tggaaatcaa gcgtacggta gcggccccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         702


<210>  23
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gH2 V-region

<400>  23

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro Tyr Arg Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125 


<210>  24
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gH2 V-region

<400>  24
gaagtgacac tcaaggagtc tggacccgct ctggtgaaac caacccaaac actcactttg       60

acatgtactt ttagtggctt ctcattgact acctatggaa tgggcgtggg atggatcaga      120

cagccacctg gcaaggctct ggaatggctg gccaacatct ggtgggatga cgacaagtac      180

tataacccgt ccctgaaaaa ccggctgacc attagcaagg atacttctaa aaatcaagtg      240

gtgctgacca tgacaaatat ggatcccgtt gacaccgcaa cctactactg cgcccgcatt      300

ggtcccataa agtaccctac ggcaccttac cgatatttcg acttttgggg ccaagggaca      360

atggttactg tctcg                                                       375


<210>  25
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gH2 V-region with signal sequence underlined and italicized

<400>  25

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys 
            20                  25                  30          


Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro 
        115                 120                 125             


Tyr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


<210>  26
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gH2 V-region with signal sequence underlined and italicized

<400>  26
atggagtggt cctgggtgtt tctgttcttc ctgagtgtga ccaccggggt ccactccgaa       60

gtgacactca aggagtctgg acccgctctg gtgaaaccaa cccaaacact cactttgaca      120

tgtactttta gtggcttctc attgactacc tatggaatgg gcgtgggatg gatcagacag      180

ccacctggca aggctctgga atggctggcc aacatctggt gggatgacga caagtactat      240

aacccgtccc tgaaaaaccg gctgaccatt agcaaggata cttctaaaaa tcaagtggtg      300

ctgaccatga caaatatgga tcccgttgac accgcaacct actactgcgc ccgcattggt      360

cccataaagt accctacggc accttaccga tatttcgact tttggggcca agggacaatg      420

gttactgtct cg                                                          432


<210>  27
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gH2 heavy chain (V + constant - hu IgG4P)

<400>  27

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro Tyr Arg Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210>  28
<211>  1966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gH2 heavy chain (V + constant - hu IgG4P, exons underlined)

<400>  28
gaagtgacac tcaaggagtc tggacccgct ctggtgaaac caacccaaac actcactttg       60

acatgtactt ttagtggctt ctcattgact acctatggaa tgggcgtggg atggatcaga      120

cagccacctg gcaaggctct ggaatggctg gccaacatct ggtgggatga cgacaagtac      180

tataacccgt ccctgaaaaa ccggctgacc attagcaagg atacttctaa aaatcaagtg      240

gtgctgacca tgacaaatat ggatcccgtt gacaccgcaa cctactactg cgcccgcatt      300

ggtcccataa agtaccctac ggcaccttac cgatatttcg acttttgggg ccaagggaca      360

atggttactg tctcgagcgc ttctacaaag ggcccatccg tcttccccct ggcgccctgc      420

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cgaagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      660

gacaagagag ttggtgagag gccagcacag ggagggaggg tgtctgctgg aagccaggct      720

cagccctcct gcctggacgc accccggctg tgcagcccca gcccagggca gcaaggcatg      780

ccccatctgt ctcctcaccc ggaggcctct gaccacccca ctcatgccca gggagagggt      840

cttctggatt tttccaccag gctccgggca gccacaggct ggatgcccct accccaggcc      900

ctgcgcatac aggggcaggt gctgcgctca gacctgccaa gagccatatc cgggaggacc      960

ctgcccctga cctaagccca ccccaaaggc caaactctcc actccctcag ctcagacacc     1020

ttctctcctc ccagatctga gtaactccca atcttctctc tgcagagtcc aaatatggtc     1080

ccccatgccc accatgccca ggtaagccaa cccaggcctc gccctccagc tcaaggcggg     1140

acaggtgccc tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacgcatcc     1200

acctccatct cttcctcagc acctgagttc ctggggggac catcagtctt cctgttcccc     1260

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg     1320

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1380

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc     1440

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1500

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg tgggacccac     1560

ggggtgcgag ggccacatgg acagaggtca gctcggccca ccctctgccc tgggagtgac     1620

cgctgtgcca acctctgtcc ctacagggca gccccgagag ccacaggtgt acaccctgcc     1680

cccatcccag gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt     1740

ctaccccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa     1800

gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctaaccgt     1860

ggacaagagc aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct     1920

gcacaaccac tacacacaga agagcctctc cctgtctctg ggtaaa                    1966


<210>  29
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  969 gH2 heavy chain (V + constant - hu IgG4P) with signal 
       sequence underlined and italicised

<400>  29

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys 
            20                  25                  30          


Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro 
        115                 120                 125             


Tyr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470         


<210>  30
<211>  2023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  969 gH2 heavy chain (V + constant - hu IgG4P, exons underlined) 
       with signal sequence underlined and italicized

<400>  30
atggagtggt cctgggtgtt tctgttcttc ctgagtgtga ccaccggggt ccactccgaa       60

gtgacactca aggagtctgg acccgctctg gtgaaaccaa cccaaacact cactttgaca      120

tgtactttta gtggcttctc attgactacc tatggaatgg gcgtgggatg gatcagacag      180

ccacctggca aggctctgga atggctggcc aacatctggt gggatgacga caagtactat      240

aacccgtccc tgaaaaaccg gctgaccatt agcaaggata cttctaaaaa tcaagtggtg      300

ctgaccatga caaatatgga tcccgttgac accgcaacct actactgcgc ccgcattggt      360

cccataaagt accctacggc accttaccga tatttcgact tttggggcca agggacaatg      420

gttactgtct cgagcgcttc tacaaagggc ccatccgtct tccccctggc gccctgctcc      480

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcacga agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      720

aagagagttg gtgagaggcc agcacaggga gggagggtgt ctgctggaag ccaggctcag      780

ccctcctgcc tggacgcacc ccggctgtgc agccccagcc cagggcagca aggcatgccc      840

catctgtctc ctcacccgga ggcctctgac caccccactc atgcccaggg agagggtctt      900

ctggattttt ccaccaggct ccgggcagcc acaggctgga tgcccctacc ccaggccctg      960

cgcatacagg ggcaggtgct gcgctcagac ctgccaagag ccatatccgg gaggaccctg     1020

cccctgacct aagcccaccc caaaggccaa actctccact ccctcagctc agacaccttc     1080

tctcctccca gatctgagta actcccaatc ttctctctgc agagtccaaa tatggtcccc     1140

catgcccacc atgcccaggt aagccaaccc aggcctcgcc ctccagctca aggcgggaca     1200

ggtgccctag agtagcctgc atccagggac aggccccagc cgggtgctga cgcatccacc     1260

tccatctctt cctcagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca     1320

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac     1380

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat     1440

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc     1500

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1560

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaaggtgg gacccacggg     1620

gtgcgagggc cacatggaca gaggtcagct cggcccaccc tctgccctgg gagtgaccgc     1680

tgtgccaacc tctgtcccta cagggcagcc ccgagagcca caggtgtaca ccctgccccc     1740

atcccaggag gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta     1800

ccccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     1860

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaggc taaccgtgga     1920

caagagcagg tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca     1980

caaccactac acacagaaga gcctctccct gtctctgggt aaa                       2023


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VK1 2-1-(1) O12 JK4 acceptor framework

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VK1 2-1-(1) O12 JK4 acceptor framework

<400>  32
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  33
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VH2 3-1 2-70 JH3 acceptor framework

<400>  33

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Arg Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Phe Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  34
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH2 3-1 2-70 JH3 acceptor framework

<400>  34
caggtcacct tgaaggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcacct tctctgggtt ctcactcagc actagtggaa tgcgtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaattc      180

tacagcacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

gcttttgata tctggggcca agggacaatg gtcaccgtct ct                         342


<210>  35
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for CSF-1R

<400>  35

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  36
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for CSF-1R

<400>  36

Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys Pro Gly 
1               5                   10                  15      


Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu Trp Asp 
            20                  25                  30          


Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr Tyr Arg 
    50                  55                  60                  


Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile His Leu 
65                  70                  75                  80  


Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val 
                85                  90                  95      


Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp 
            100                 105                 110         


Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro 
        115                 120                 125             


Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr 
    130                 135                 140                 


Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala 
145                 150                 155                 160 


Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val 
                165                 170                 175     


Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu 
            180                 185                 190         


Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser 
        195                 200                 205             


Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys 
    210                 215                 220                 


Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Lys 
225                 230                 235                 240 


Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly Asn 
                245                 250                 255     


Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser Thr Ser Met 
            260                 265                 270         


Phe Phe Arg Val Val 
        275         


<210>  37
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for CSF-1R

<400>  37

Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr Ile 
1               5                   10                  15      


His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu 
            20                  25                  30          


Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val Gln 
        35                  40                  45              


Lys 
    


<210>  38
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for CSF-1R (SNP V32G, A245S, H247P, V279M, 
       position underlined)

<400>  38

Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys Pro Gly 
1               5                   10                  15      


Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu Trp Asp 
            20                  25                  30          


Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr Tyr Arg 
    50                  55                  60                  


Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile His Leu 
65                  70                  75                  80  


Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val 
                85                  90                  95      


Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp 
            100                 105                 110         


Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro 
        115                 120                 125             


Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr 
    130                 135                 140                 


Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala 
145                 150                 155                 160 


Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val 
                165                 170                 175     


Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu 
            180                 185                 190         


Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser 
        195                 200                 205             


Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys 
    210                 215                 220                 


Leu Ala Ile His Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Lys 
225                 230                 235                 240 


Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly Asn 
                245                 250                 255     


Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser Thr Ser Met 
            260                 265                 270         


Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser Ser Glu Gln 
        275                 280                 285             


Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn Leu Lys Val 
    290                 295                 300                 


Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp Thr Tyr Leu 
305                 310                 315                 320 


Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala Asn Ala Thr 
                325                 330                 335     


Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu Pro Arg Leu 
            340                 345                 350         


Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg Asn Pro Gly 
        355                 360                 365             


Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro Glu 
    370                 375                 380                 


Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr Leu Leu Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu Gln Cys Ser 
                405                 410                 415     


Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln Val Trp Asp 
            420                 425                 430         


Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His Lys Val Thr 
        435                 440                 445             


Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn Gln Thr Tyr 
    450                 455                 460                 


Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp Ala Phe Ile 
465                 470                 475                 480 


Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
                485                 490             


<210>  39
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of human CSF-1R extracellular domain

<400>  39

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


