                         SEQUENCE LISTING

<110>  University of Copenhagen
 
<120>  Anti-ADAM12 antibodies for the treatment of cancer

<130>  P3309PC00

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  909
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(28)

<220>
<221>  DOMAIN
<222>  (1)..(909)
<223>  ADAM12-L

<220>
<221>  PROPEP
<222>  (29)..(206)
<223>  Prodomain

<220>
<221>  SITE
<222>  (111)..(113)
<223>  N-glycosylation site

<220>
<221>  SITE
<222>  (149)..(151)
<223>  N-glycosylation site

<220>
<221>  ACT_SITE
<222>  (207)..(417)
<223>  Metalloprotease

<220>
<221>  BINDING
<222>  (418)..(512)
<223>  Disintegrin domain

<220>
<221>  DOMAIN
<222>  (513)..(588)
<223>  cysteine-rich domain

<220>
<221>  DOMAIN
<222>  (589)..(614)
<223>  Fusion-like domain

<220>
<221>  DOMAIN
<222>  (615)..(708)
<223>  EGF-like domain

<220>
<221>  TRANSMEM
<222>  (709)..(729)

<220>
<221>  DOMAIN
<222>  (730)..(909)
<223>  cytoplasmic tail

<400>  1

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  2
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(178)
<223>  Prodomain sequence of ADAM12-L, corresponding to amino acids 29 
       to 206 of SEQ ID NO: 1

<400>  2

Arg Gly Val Ser Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser 
1               5                   10                  15      


Ala Ser Val Gly Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp 
            20                  25                  30          


Ser Lys Asn His Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser 
        35                  40                  45              


Lys Glu Leu Ile Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser 
    50                  55                  60                  


Ser Phe Thr Glu Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu 
65                  70                  75                  80  


Ala Arg Asn Tyr Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His 
                85                  90                  95      


Val Arg Gly Tyr Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly 
            100                 105                 110         


Leu Arg Gly Leu Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro 
        115                 120                 125             


Met Lys Ser Ala Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu 
    130                 135                 140                 


Lys Ser Val Arg Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu 
145                 150                 155                 160 


Ala Ala Lys Asn Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg 
                165                 170                 175     


His Lys 
        


<210>  3
<211>  5062
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mRNA
<222>  (1)..(5062)
<223>  ADAM12-L mRNA GenBank: AF023476.2

<220>
<221>  misc_feature
<222>  (391)..(924)
<223>  prodomain sequence

<400>  3
cactaacgct cttcctagtc cccgggccaa ctcggacagt ttgctcattt attgcaacgg       60

tcaaggctgg cttgtgccag aacggcgcgc gcgcgacgca cgcacacaca cggggggaaa      120

cttttttaaa aatgaaaggc tagaagagct cagcggcggc gcgggccgtg cgcgagggct      180

ccggagctga ctcgccgagg caggaaatcc ctccggtcgc gacgcccggc cccgctcggc      240

gcccgcgtgg gatggtgcag cgctcgccgc cgggcccgag agctgctgca ctgaaggccg      300

gcgacgatgg cagcgcgccc gctgcccgtg tcccccgccc gcgccctcct gctcgccctg      360

gccggtgctc tgctcgcgcc ctgcgaggcc cgaggggtga gcttatggaa ccaaggaaga      420

gctgatgaag ttgtcagtgc ctctgttcgg agtggggacc tctggatccc agtgaagagc      480

ttcgactcca agaatcatcc agaagtgctg aatattcgac tacaacggga aagcaaagaa      540

ctgatcataa atctggaaag aaatgaaggt ctcattgcca gcagtttcac ggaaacccac      600

tatctgcaag acggtactga tgtctccctc gctcgaaatt acacggtaat tctgggtcac      660

tgttactacc atggacatgt acggggatat tctgattcag cagtcagtct cagcacgtgt      720

tctggtctca ggggacttat tgtgtttgaa aatgaaagct atgtcttaga accaatgaaa      780

agtgcaacca acagatacaa actcttccca gcgaagaagc tgaaaagcgt ccggggatca      840

tgtggatcac atcacaacac accaaacctc gctgcaaaga atgtgtttcc accaccctct      900

cagacatggg caagaaggca taaaagagag accctcaagg caactaagta tgtggagctg      960

gtgatcgtgg cagacaaccg agagtttcag aggcaaggaa aagatctgga aaaagttaag     1020

cagcgattaa tagagattgc taatcacgtt gacaagtttt acagaccact gaacattcgg     1080

atcgtgttgg taggcgtgga agtgtggaat gacatggaca aatgctctgt aagtcaggac     1140

ccattcacca gcctccatga atttctggac tggaggaaga tgaagcttct acctcgcaaa     1200

tcccatgaca atgcgcagct tgtcagtggg gtttatttcc aagggaccac catcggcatg     1260

gccccaatca tgagcatgtg cacggcagac cagtctgggg gaattgtcat ggaccattca     1320

gacaatcccc ttggtgcagc cgtgaccctg gcacatgagc tgggccacaa tttcgggatg     1380

aatcatgaca cactggacag gggctgtagc tgtcaaatgg cggttgagaa aggaggctgc     1440

atcatgaacg cttccaccgg gtacccattt cccatggtgt tcagcagttg cagcaggaag     1500

gacttggaga ccagcctgga gaaaggaatg ggggtgtgcc tgtttaacct gccggaagtc     1560

agggagtctt tcgggggcca gaagtgtggg aacagatttg tggaagaagg agaggagtgt     1620

gactgtgggg agccagagga atgtatgaat cgctgctgca atgccaccac ctgtaccctg     1680

aagccggacg ctgtgtgcgc acatgggctg tgctgtgaag actgccagct gaagcctgca     1740

ggaacagcgt gcagggactc cagcaactcc tgtgacctcc cagagttctg cacaggggcc     1800

agccctcact gcccagccaa cgtgtacctg cacgatgggc actcatgtca ggatgtggac     1860

ggctactgct acaatggcat ctgccagact cacgagcagc agtgtgtcac actctgggga     1920

ccaggtgcta aacctgcccc tgggatctgc tttgagagag tcaattctgc aggtgatcct     1980

tatggcaact gtggcaaagt ctcgaagagt tcctttgcca aatgcgagat gagagatgct     2040

aaatgtggaa aaatccagtg tcaaggaggt gccagccggc cagtcattgg taccaatgcc     2100

gtttccatag aaacaaacat ccccctgcag caaggaggcc ggattctgtg ccgggggacc     2160

cacgtgtact tgggcgatga catgccggac ccagggcttg tgcttgcagg cacaaagtgt     2220

gcagatggaa aaatctgcct gaatcgtcaa tgtcaaaata ttagtgtctt tggggttcac     2280

gagtgtgcaa tgcagtgcca cggcagaggg gtgtgcaaca acaggaagaa ctgccactgc     2340

gaggcccact gggcacctcc cttctgtgac aagtttggct ttggaggaag cacagacagc     2400

ggccccatcc ggcaagcaga taaccaaggt ttaaccatag gaattctggt gaccatcctg     2460

tgtcttcttg ctgccggatt tgtggtttat ctcaaaagga agaccttgat acgactgctg     2520

tttacaaata agaagaccac cattgaaaaa ctaaggtgtg tgcgcccttc ccggccaccc     2580

cgtggcttcc aaccctgtca ggctcacctc ggccaccttg gaaaaggcct gatgaggaag     2640

ccgccagatt cctacccacc gaaggacaat cccaggagat tgctgcagtg tcagaatgtt     2700

gacatcagca gacccctcaa cggcctgaat gtccctcagc cccagtcaac tcagcgagtg     2760

cttcctcccc tccaccgggc cccacgtgca cctagcgtcc ctgccagacc cctgccagcc     2820

aagcctgcac ttaggcaggc ccaggggacc tgtaagccaa acccccctca gaagcctctg     2880

cctgcagatc ctctggccag aacaactcgg ctcactcatg ccttggccag gaccccagga     2940

caatgggaga ctgggctccg cctggcaccc ctcagacctg ctccacaata tccacaccaa     3000

gtgcccagat ccacccacac cgcctatatt aagtgagaag ccgacacctt ttttcaacag     3060

tgaagacaga agtttgcact atctttcagc tccagttgga gttttttgta ccaactttta     3120

ggattttttt taatgtttaa aacatcatta ctataagaac tttgagctac tgccgtcagt     3180

gctgtgctgt gctatggtgc tctgtctact tgcacaggta cttgtaaatt attaatttat     3240

gcagaatgtt gattacagtg cagtgcgctg tagtaggcat ttttaccatc actgagtttt     3300

ccatggcagg aaggcttgtt gtgcttttag tattttagtg aacttgaaat atcctgcttg     3360

atgggattct ggacaggatg tgtttgcttt ctgatcaagg ccttattgga aagcagtccc     3420

ccaactaccc ccagctgtgc ttatggtacc agatgcagct caagagatcc caagtagaat     3480

ctcagttgat tttctggatt ccccatctca ggccagagcc aaggggcttc aggtccaggc     3540

tgtgtttggc tttcagggag gccctgtgcc ccttgacaac tggcaggcag gctcccaggg     3600

acacctggga gaaatctggc ttctggccag gaagctttgg tgagaacctg ggttgcagac     3660

aggaatctta aggtgtagcc acaccaggat agagactgga acactagaca agccagaact     3720

tgaccctgag ctgaccagcc gtgagcatgt ttggaagggg tctgtagtgt cactcaaggc     3780

ggtgcttgat agaaatgcca agcacttctt tttctcgctg tcctttctag agcactgcca     3840

ccagtaggtt atttagcttg ggaaaggtgg tgtttctgta agaaacctac tgcccaggca     3900

ctgcaaaccg ccacctccct atactgcttg gagctgagca aatcaccaca aactgtaata     3960

caatgatcct gtattcagac agatgaggac tttccatggg accacaacta ttttcagatg     4020

tgaaccatta accagatcta gtcaatcaag tctgtttact gcaaggttca acttattaac     4080

aattaggcag actctttatg cttgcaaaaa ctacaaccaa tggaatgtga tgttcatggg     4140

tatagttcat gtctgctatc attattcgta gatattggac aaagaacctt ctctatgggg     4200

catcctcttt ttccaacttg gctgcaggaa tctttaaaag atgcttttaa cagagtctga     4260

acctatttct taaacacttg caacctacct gttgagcatc acagaatgtg ataaggaaat     4320

caacttgctt atcaacttcc taaatattat gagatgtggc ttgggcagca tccccttgaa     4380

ctcttcactc ttcaaatgcc tgactaggga gccatgtttc acaaggtctt taaagtgact     4440

aatggcatga gaaatacaaa aatactcaga taaggtaaaa tgccatgatg cctctgtctt     4500

ctggactggt tttcacatta gaagacaatt gacaacagtt acataattca ctctgagtgt     4560

tttatgagaa agccttcttt tggggtcaac agttttccta tgctttgaaa cagaaaaata     4620

tgtaccaaga atcttggttt gccttccaga aaacaaaact gcatttcact ttcccggtgt     4680

tccccactgt atctaggcaa catagtattc atgactatgg ataaactaaa cacgtgacac     4740

aaacacacac aaaagggaac ccagctctaa tacattccaa ctcgtatagc atgcatctgt     4800

ttattctata gttattaagt tctttaaaat gtaaagccat gctggaaaat aatactgctg     4860

agatacatac agaattactg taactgatta cacttggtaa ttgtactaaa gccaaacata     4920

tatatactat taaaaaggtt tacagaattt tatggtgcat tacgtgggca ttgtcttttt     4980

agatgcccaa atccttagat ctggcatgtt agcccttcct ccaattataa gaggatatga     5040

accaaaaaaa aaaaaaaaaa aa                                              5062


<210>  4
<211>  540
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(540)
<223>  UniProt P50281 MMP-14

<400>  4

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala 
    530                 535                 540 


<210>  5
<211>  3558
<212>  DNA
<213>  Homo sapiens


<220>
<221>  mRNA
<222>  (1)..(3558)
<223>  MMP-14 NCBI reference sequence: NM_004995.2

<400>  5
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag       60

caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt      120

caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg      180

cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct      240

cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc      300

gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat      360

ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca      420

gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca      480

gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag      540

atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat      600

gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag      660

gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg      720

ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc      780

gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc      840

tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact      900

gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc      960

catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag     1020

tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt     1080

tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg     1140

ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac     1200

tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg     1260

cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg     1320

ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc     1380

aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac     1440

attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg     1500

cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc     1560

agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct     1620

cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa     1680

tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg     1740

agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg     1800

gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg     1860

gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc     1920

agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc     1980

tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg     2040

gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc     2100

ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc     2160

ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc     2220

cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt     2280

gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg     2340

gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag     2400

gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact     2460

ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg     2520

ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt     2580

gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc     2640

aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt     2700

gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt     2760

gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag     2820

cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa     2880

ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc     2940

attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct     3000

gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt     3060

gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca     3120

cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc     3180

cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg     3240

cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc     3300

cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg     3360

gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg     3420

gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt     3480

ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattccaaa     3540

aaaaaaaaaa aaaaaaaa                                                   3558


