                         SEQUENCE LISTING

<110>  E.I. DUPONT DE NEMOURS AND COMPANY and 
       PIONEER HI-BRED INTERNATIONAL, INC.
       Cigan, Mark
       Falco, Carl
       Li, Zhongsen
       Liu, Zhan-Bin
       Young, Josh
 
<120>  A SOYBEAN U6 POLYMERASE III PROMOTER AND METHODS OF USE

<130>  BB2450 PCT

<150>  61/868706
<151>  2013-08-22

<150>  61/882532
<151>  2013-09-25

<150>  61/937045
<151>  2014-02-07

<150>  61/953090
<151>  2014-03-14

<150>  62/023239
<151>  2014-07-11

<160>  550   

<170>  PatentIn version 3.5

<210>  1
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes M1 GAS (SF370)

<400>  1
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  2
<211>  189
<212>  DNA
<213>  Solanum tuberosum

<400>  2
gtaagtttct gcttctacct ttgatatata tataataatt atcattaatt agtagtaata       60

taatatttca aatatttttt tcaaaataaa agaatgtagt atatagcaat tgcttttctg      120

tagtttataa gtgtgtatat tttaatttat aacttttcta atatatgacc aaaacatggt      180

gatgtgcag                                                              189


<210>  3
<211>  9
<212>  PRT
<213>  Simian virus 40

<400>  3

Met Ala Pro Lys Lys Lys Arg Lys Val 
1               5                   


<210>  4
<211>  18
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  4

Lys Arg Pro Arg Asp Arg His Asp Gly Glu Leu Gly Gly Arg Lys Arg 
1               5                   10                  15      


Ala Arg 
        


<210>  5
<211>  6717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maize optimized Cas9 expression cassette

<400>  5
gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta       60

taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      120

atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      180

gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt      240

ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg      300

caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta      360

gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct      420

ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa      480

tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta      540

aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt      600

ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca      660

cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg      720

ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag      780

gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc      840

ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctttccc      900

caacctcgtg ttgttcggag cgcacacaca cacaaccaga tctcccccaa atccacccgt      960

cggcacctcc gcttcaaggt acgccgctcg tcctcccccc cccccctctc taccttctct     1020

agatcggcgt tccggtccat gcatggttag ggcccggtag ttctacttct gttcatgttt     1080

gtgttagatc cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct     1140

gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg aatcctggga     1200

tggctctagc cgttccgcag acgggatcga tttcatgatt ttttttgttt cgttgcatag     1260

ggtttggttt gcccttttcc tttatttcaa tatatgccgt gcacttgttt gtcgggtcat     1320

cttttcatgc ttttttttgt cttggttgtg atgatgtggt ctggttgggc ggtcgttcta     1380

gatcggagta gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg     1440

tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat atcgatctag     1500

gataggtata catgttgatg cgggttttac tgatgcatat acagagatgc tttttgttcg     1560

cttggttgtg atgatgtggt gtggttgggc ggtcgttcat tcgttctaga tcggagtaga     1620

atactgtttc aaactacctg gtgtatttat taattttgga actgtatgtg tgtgtcatac     1680

atcttcatag ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt     1740

tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat tcatatgctc     1800

taaccttgag tacctatcta ttataataaa caagtatgtt ttataattat tttgatcttg     1860

atatacttgg atgatggcat atgcagcagc tatatgtgga tttttttagc cctgccttca     1920

tacgctattt atttgcttgg tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt     1980

tacttctgca ggtcgactct agaggatcca tggcaccgaa gaagaagcgc aaggtgatgg     2040

acaagaagta cagcatcggc ctcgacatcg gcaccaactc ggtgggctgg gccgtcatca     2100

cggacgaata taaggtcccg tcgaagaagt tcaaggtcct cggcaataca gaccgccaca     2160

gcatcaagaa aaacttgatc ggcgccctcc tgttcgatag cggcgagacc gcggaggcga     2220

ccaggctcaa gaggaccgcc aggagacggt acactaggcg caagaacagg atctgctacc     2280

tgcaggagat cttcagcaac gagatggcga aggtggacga ctccttcttc caccgcctgg     2340

aggaatcatt cctggtggag gaggacaaga agcatgagcg gcacccaatc ttcggcaaca     2400

tcgtcgacga ggtaagtttc tgcttctacc tttgatatat atataataat tatcattaat     2460

tagtagtaat ataatatttc aaatattttt ttcaaaataa aagaatgtag tatatagcaa     2520

ttgcttttct gtagtttata agtgtgtata ttttaattta taacttttct aatatatgac     2580

caaaacatgg tgatgtgcag gtggcctacc acgagaagta cccgacaatc taccacctcc     2640

ggaagaaact ggtggacagc acagacaagg cggacctccg gctcatctac cttgccctcg     2700

cgcatatgat caagttccgc ggccacttcc tcatcgaggg cgacctgaac ccggacaact     2760

ccgacgtgga caagctgttc atccagctcg tgcagacgta caatcaactg ttcgaggaga     2820

accccataaa cgctagcggc gtggacgcca aggccatcct ctcggccagg ctctcgaaat     2880

caagaaggct ggagaacctt atcgcgcagt tgccaggcga aaagaagaac ggcctcttcg     2940

gcaaccttat tgcgctcagc ctcggcctga cgccgaactt caaatcaaac ttcgacctcg     3000

cggaggacgc caagctccag ctctcaaagg acacctacga cgacgacctc gacaacctcc     3060

tggcccagat aggagaccag tacgcggacc tcttcctcgc cgccaagaac ctctccgacg     3120

ctatcctgct cagcgacatc cttcgggtca acaccgaaat taccaaggca ccgctgtccg     3180

ccagcatgat taaacgctac gacgagcacc atcaggacct cacgctgctc aaggcactcg     3240

tccgccagca gctccccgag aagtacaagg agatcttctt cgaccaatca aaaaacggct     3300

acgcgggata tatcgacggc ggtgccagcc aggaagagtt ctacaagttc atcaaaccaa     3360

tcctggagaa gatggacggc accgaggagt tgctggtcaa gctcaacagg gaggacctcc     3420

tcaggaagca gaggaccttc gacaacggct ccatcccgca tcagatccac ctgggcgaac     3480

tgcatgccat cctgcggcgc caggaggact tctacccgtt cctgaaggat aaccgggaga     3540

agatcgagaa gatcttgacg ttccgcatcc catactacgt gggcccgctg gctcgcggca     3600

actcccggtt cgcctggatg acccggaagt cggaggagac catcacaccc tggaactttg     3660

aggaggtggt cgataagggc gctagcgctc agagcttcat cgagcgcatg accaacttcg     3720

ataaaaacct gcccaatgaa aaagtcctcc ccaagcactc gctgctctac gagtacttca     3780

ccgtgtacaa cgagctcacc aaggtcaaat acgtcaccga gggcatgcgg aagccggcgt     3840

tcctgagcgg cgagcagaag aaggcgatag tggacctcct cttcaagacc aacaggaagg     3900

tgaccgtgaa gcaattaaaa gaggactact tcaagaaaat agagtgcttc gactccgtgg     3960

agatctcggg cgtggaggat cggttcaacg cctcactcgg cacgtatcac gacctcctca     4020

agatcattaa agacaaggac ttcctcgaca acgaggagaa cgaggacatc ctcgaggaca     4080

tcgtcctcac cctgaccctg ttcgaggacc gcgaaatgat cgaggagagg ctgaagacct     4140

acgcgcacct gttcgacgac aaggtcatga aacagctcaa gaggcgccgc tacactggtt     4200

ggggaaggct gtcccgcaag ctcattaatg gcatcaggga caagcagagc ggcaagacca     4260

tcctggactt cctcaagtcc gacgggttcg ccaaccgcaa cttcatgcag ctcattcacg     4320

acgactcgct cacgttcaag gaagacatcc agaaggcaca ggtgagcggg cagggtgact     4380

ccctccacga acacatcgcc aacctggccg gctcgccggc cattaaaaag ggcatcctgc     4440

agacggtcaa ggtcgtcgac gagctcgtga aggtgatggg ccggcacaag cccgaaaata     4500

tcgtcataga gatggccagg gagaaccaga ccacccaaaa agggcagaag aactcgcgcg     4560

agcggatgaa acggatcgag gagggcatta aagagctcgg gtcccagatc ctgaaggagc     4620

accccgtgga aaatacccag ctccagaatg aaaagctcta cctctactac ctgcagaacg     4680

gccgcgacat gtacgtggac caggagctgg acattaatcg gctatcggac tacgacgtcg     4740

accacatcgt gccgcagtcg ttcctcaagg acgatagcat cgacaacaag gtgctcaccc     4800

ggtcggataa aaatcggggc aagagcgaca acgtgcccag cgaggaggtc gtgaagaaga     4860

tgaaaaacta ctggcgccag ctcctcaacg cgaaactgat cacccagcgc aagttcgaca     4920

acctgacgaa ggcggaacgc ggtggcttga gcgaactcga taaggcgggc ttcataaaaa     4980

ggcagctggt cgagacgcgc cagatcacga agcatgtcgc ccagatcctg gacagccgca     5040

tgaatactaa gtacgatgaa aacgacaagc tgatccggga ggtgaaggtg atcacgctga     5100

agtccaagct cgtgtcggac ttccgcaagg acttccagtt ctacaaggtc cgcgagatca     5160

acaactacca ccacgcccac gacgcctacc tgaatgcggt ggtcgggacc gccctgatca     5220

agaagtaccc gaagctggag tcggagttcg tgtacggcga ctacaaggtc tacgacgtgc     5280

gcaaaatgat cgccaagtcc gagcaggaga tcggcaaggc cacggcaaaa tacttcttct     5340

actcgaacat catgaacttc ttcaagaccg agatcaccct cgcgaacggc gagatccgca     5400

agcgcccgct catcgaaacc aacggcgaga cgggcgagat cgtctgggat aagggccggg     5460

atttcgcgac ggtccgcaag gtgctctcca tgccgcaagt caatatcgtg aaaaagacgg     5520

aggtccagac gggcgggttc agcaaggagt ccatcctccc gaagcgcaac tccgacaagc     5580

tcatcgcgag gaagaaggat tgggacccga aaaaatatgg cggcttcgac agcccgaccg     5640

tcgcatacag cgtcctcgtc gtggcgaagg tggagaaggg caagtcaaag aagctcaagt     5700

ccgtgaagga gctgctcggg atcacgatta tggagcggtc ctccttcgag aagaacccga     5760

tcgacttcct agaggccaag ggatataagg aggtcaagaa ggacctgatt attaaactgc     5820

cgaagtactc gctcttcgag ctggaaaacg gccgcaagag gatgctcgcc tccgcaggcg     5880

agttgcagaa gggcaacgag ctcgccctcc cgagcaaata cgtcaatttc ctgtacctcg     5940

ctagccacta tgaaaagctc aagggcagcc cggaggacaa cgagcagaag cagctcttcg     6000

tggagcagca caagcattac ctggacgaga tcatcgagca gatcagcgag ttctcgaagc     6060

gggtgatcct cgccgacgcg aacctggaca aggtgctgtc ggcatataac aagcaccgcg     6120

acaaaccaat acgcgagcag gccgaaaata tcatccacct cttcaccctc accaacctcg     6180

gcgctccggc agccttcaag tacttcgaca ccacgattga ccggaagcgg tacacgagca     6240

cgaaggaggt gctcgatgcg acgctgatcc accagagcat cacagggctc tatgaaacac     6300

gcatcgacct gagccagctg ggcggagaca agagaccacg ggaccgccac gatggcgagc     6360

tgggaggccg caagcgggca aggtaggtac cgttaaccta gacttgtcca tcttctggat     6420

tggccaactt aattaatgta tgaaataaaa ggatgcacac atagtgacat gctaatcact     6480

ataatgtggg catcaaagtt gtgtgttatg tgtaattact agttatctga ataaaagaga     6540

aagagatcat ccatatttct tatcctaaat gaatgtcacg tgtctttata attctttgat     6600

gaaccagatg catttcatta accaaatcca tatacatata aatattaatc atatataatt     6660

aatatcaatt gggttagcaa aacaaatcta gtctaggtgt gttttgcgaa tgcggcc        6717


<210>  6
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA containing the LIGCas-3 target sequence in the variable 
       targeting domain

<400>  6
gcguacgcgu acgugugguu uuagagcuau gcuguuuug                              39


<210>  7
<211>  86
<212>  RNA
<213>  Streptococcus pyogenes M1 GAS (SF370)


<220>
<221>  tracRNA
<222>  (1)..(86)

<400>  7
ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugcu uuuuuu                                            86


<210>  8
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Long guide RNA containing the LIGCas-3 target sequence in the 
       variable targeting domain

<400>  8
gcguacgcgu acgugugguu uuagagcuag aaauagcaag uuaaaauaag gcuaguccgu       60

uaucaacuug aaaaaguggc accgagucgg ugcu                                   94


<210>  9
<211>  1000
<212>  DNA
<213>  Zea mays

<400>  9
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt                           1000


<210>  10
<211>  16
<212>  DNA
<213>  Zea mays

<400>  10
tttttttttt tttttt                                                       16


<210>  11
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Short guide RNA containing the LIGCas-3 variable targeting domain

<400>  11
gcguacgcgu acgugugguu uuagagcuag aaauagcaag uuaaaauaag gcuaguccg        59


<210>  12
<211>  1102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maize optimized long guide RNA expression cassette containing the
       LIGCas-3 variable targeting domain

<400>  12
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcgtacgcgt acgtgtggtt     1020

ttagagctag aaatagcaag ttaaaataag gctagtccgt tatcaacttg aaaaagtggc     1080

accgagtcgg tgcttttttt tt                                              1102


<210>  13
<211>  27
<212>  DNA
<213>  Zea mays

<400>  13
gtactccatc cgccccatcg agtaggg                                           27


<210>  14
<211>  24
<212>  DNA
<213>  Zea mays

<400>  14
gcacgtacgt caccatcccg ccgg                                              24


<210>  15
<211>  24
<212>  DNA
<213>  Zea mays

<400>  15
gacgtacgtg ccctactcga tggg                                              24


<210>  16
<211>  24
<212>  DNA
<213>  Zea mays

<400>  16
gtaccgtacg tgccccggcg gagg                                              24


<210>  17
<211>  24
<212>  DNA
<213>  Zea mays

<400>  17
ggaattgtac cgtacgtgcc ccgg                                              24


<210>  18
<211>  20
<212>  DNA
<213>  Zea mays

<400>  18
gcgtacgcgt acgtgtgagg                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Zea mays

<400>  19
gctggccgag gtcgactacc gg                                                22


<210>  20
<211>  23
<212>  DNA
<213>  Zea mays

<400>  20
ggccgaggtc gactaccggc cgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Zea mays

<400>  21
ggcgcgagct cgtgcttcac cgg                                               23


<210>  22
<211>  21
<212>  DNA
<213>  Zea mays

<400>  22
ggtgccaatc atgcgtcgcg g                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Zea mays

<400>  23
ggtcgccatc acgggacagg                                                   20


<210>  24
<211>  24
<212>  DNA
<213>  Zea mays

<400>  24
gtcgcggcac ctgtcccgtg atgg                                              24


<210>  25
<211>  23
<212>  DNA
<213>  Zea mays

<400>  25
ggaatgctgg aactgcaatg cgg                                               23


<210>  26
<211>  24
<212>  DNA
<213>  Zea mays

<400>  26
gcagctcttc ttggggaatg ctgg                                              24


<210>  27
<211>  23
<212>  DNA
<213>  Zea mays

<400>  27
gcagtaacag ctgctgtcaa tgg                                               23


<210>  28
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26Cas-1 forward primer

<400>  28
ctacactctt tccctacacg acgctcttcc gatctaggac cggaagctcg ccgcgt           56


<210>  29
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26Cas-1 and MS26Cas-3 reverse primer

<400>  29
caagcagaag acggcatacg agctcttccg atcttcctgg aggacgacgt gctg             54


<210>  30
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26Cas-2 forward primer

<400>  30
ctacactctt tccctacacg acgctcttcc gatctaaggt cctggaggac gacgtgctg        59


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26Cas-2 and MS26 meganuclease reverse primer

<400>  31
caagcagaag acggcatacg agctcttccg atctccggaa gctcgccgcg t                51


<210>  32
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26Cas-3 forward primer

<400>  32
ctacactctt tccctacacg acgctcttcc gatcttcctc cggaagctcg ccgcgt           56


<210>  33
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS26 Meganuclease forward primer

<400>  33
ctacactctt tccctacacg acgctcttcc gatctttcct cctggaggac gacgtgctg        59


<210>  34
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-1 forward primer

<400>  34
ctacactctt tccctacacg acgctcttcc gatctaggac tgtaacgatt tacgcacctg       60

ctg                                                                     63


<210>  35
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-1 and LIGCas-2 reverse primer

<400>  35
caagcagaag acggcatacg agctcttccg atctgcaaat gagtagcagc gcacgtat         58


<210>  36
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-2 forward primer

<400>  36
ctacactctt tccctacacg acgctcttcc gatcttcctc tgtaacgatt tacgcacctg       60

ctg                                                                     63


<210>  37
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-3 forward primer

<400>  37
ctacactctt tccctacacg acgctcttcc gatctaaggc gcaaatgagt agcagcgcac       60


<210>  38
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-3 and LIG3-4 meganuclease reverse primer

<400>  38
caagcagaag acggcatacg agctcttccg atctcacctg ctgggaattg taccgta          57


<210>  39
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIG3-4 meganuclease forward primer

<400>  39
ctacactctt tccctacacg acgctcttcc gatctccttc gcaaatgagt agcagcgcac       60


<210>  40
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS45Cas-1 forward primer

<400>  40
ctacactctt tccctacacg acgctcttcc gatctaggag gacccgttcg gcctcagt         58


<210>  41
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS45Cas-1, MS45Cas-2 and MS45Cas-3 reverse primer

<400>  41
caagcagaag acggcatacg agctcttccg atctgccggc tggcattgtc tctg             54


<210>  42
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS45Cas-2 forward primer

<400>  42
ctacactctt tccctacacg acgctcttcc gatcttcctg gacccgttcg gcctcagt         58


<210>  43
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS45Cas-3 forward primer

<400>  43
ctacactctt tccctacacg acgctcttcc gatctgaagg gacccgttcg gcctcagt         58


<210>  44
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALSCas-1 forward primer

<400>  44
ctacactctt tccctacacg acgctcttcc gatctaaggc gacgatgggc gtctcctg         58


<210>  45
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALSCas-1, ALSCas-2 and ALSCas-3 reverse primer

<400>  45
caagcagaag acggcatacg agctcttccg atctgcgtct gcatcgccac ctc              53


<210>  46
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALSCas-2 forward primer

<400>  46
ctacactctt tccctacacg acgctcttcc gatctttccc gacgatgggc gtctcctg         58


<210>  47
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALSCas-3 forward primer

<400>  47
ctacactctt tccctacacg acgctcttcc gatctggaac gacgatgggc gtctcctg         58


<210>  48
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EPSPSCas-1 forward primer

<400>  48
ctacactctt tccctacacg acgctcttcc gatctggaag aggaaacata cgttgcattt       60

cca                                                                     63


<210>  49
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSPSCas-1 and EPSPSCas-3 reverse primer

<400>  49
caagcagaag acggcatacg agctcttccg atctggtgga aagttcccag ttgagga          57


<210>  50
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSPSCas-2 forward primer

<400>  50
ctacactctt tccctacacg acgctcttcc gatctaagcg gtggaaagtt cccagttgag       60

ga                                                                      62


<210>  51
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EPSPSCas-2 reverse primer

<400>  51
caagcagaag acggcatacg agctcttccg atctgaggaa acatacgttg catttcca         58


<210>  52
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EPSPSCas-3 forward primer

<400>  52
ctacactctt tccctacacg acgctcttcc gatctccttg aggaaacata cgttgcattt       60

cca                                                                     63


<210>  53
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for secondary PCR

<400>  53
aatgatacgg cgaccaccga gatctacact ctttccctac acg                         43


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for secondary PCR

<400>  54
caagcagaag acggcata                                                     18


<210>  55
<211>  93
<212>  DNA
<213>  Zea mays

<400>  55
ctgtaacgat ttacgcacct gctgggaatt gtaccgtacg tgccccggcg gaggatatat       60

atacctcaca cgtacgcgta cgcgtatata tac                                    93


<210>  56
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutation 1 for LIGCas-1 locus

<400>  56
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggtcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  57
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutation 2 for LIGCas-1 locus

<400>  57
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggacggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  58
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutation 3 for LIGCas-1 locus

<400>  58
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc gggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  59
<211>  95
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutation 4 for LIGCas-1 locus

<400>  59
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcggt cggaggatat       60

atatacctca cacgtacgcg tacgcgtata tatac                                  95


<210>  60
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 5 for LIGCas-1 locus

<400>  60
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggccggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  61
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutation 6 for LIGCas-1 locus

<400>  61
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc gcggaggata       60

tatatacctc acacgtacgc gtacgcgtat atatac                                 96


<210>  62
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 7 for LIGCas-1 locus

<400>  62
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggggaggata       60

tatatacctc acacgtacgc gtacgcgtat atatac                                 96


<210>  63
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 8 for LIGCas-1 locus

<400>  63
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggaggatata       60

tatacctcac acgtacgcgt acgcgtatat atac                                   94


<210>  64
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 8 for LIGCas-1 locus

<400>  64
aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcgtc ggaggatata       60

tatacctcac acgtacgcgt acgcgtatat atac                                   94


<210>  65
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 10 for LIGCas-1 locus

<400>  65
aggactgtaa cgatttacgc acctgctggg aattgtaccg tac                         43


<210>  66
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 1 for LIGCas-2 locus

<400>  66
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgaccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  67
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 2 for LIGCas-2 locus

<400>  67
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtccccg gcggaggata       60

tatatacctc acacgtacgc gtacgcgtat atatac                                 96


<210>  68
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 3 for LIGCas-2 locus

<400>  68
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgtccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  69
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 4 for LIGCas-2 locus

<400>  69
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacccccggc ggaggatata       60

tatacctcac acgtacgcgt acgcgtatat atac                                   94


<210>  70
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 5 for LIGCas-2 locus

<400>  70
tcctctgtaa cgatttacgc acctgctggg aattgtaccg taccccggcg gaggatatat       60

atacctcaca cgtacgcgta cgcgtatata tac                                    93


<210>  71
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 6 for LIGCas-2 locus

<400>  71
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtggccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  72
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 7  for LIGCas-2 locus

<400>  72
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacccggcgg aggatatata       60

tacctcacac gtacgcgtac gcgtatatat ac                                     92


<210>  73
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 8 for LIGCas-2 locus

<400>  73
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgaacc ccggcggagg       60

atatatatac ctcacacgta cgcgtacgcg tatatatac                              99


<210>  74
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 9 for LIGCas-2 locus

<400>  74
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgtacg cgtatatata       60

c                                                                       61


<210>  75
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 10 for LIGCas-2 locus

<400>  75
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgccccgg cggaggatat       60

atatacctca cacgtacgcg tacgcgtata tatac                                  95


<210>  76
<211>  93
<212>  DNA
<213>  Zea mays

<400>  76
cgcaaatgag tagcagcgca cgtatatata cgcgtacgcg tacgtgtgag gtatatatat       60

cctccgccgg ggcacgtacg gtacaattcc cag                                    93


<210>  77
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 1 for LIGCas-3 locus

<400>  77
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtt gtgaggtata       60

tatatcctcc gccggggcac gtacggtaca attcccag                               98


<210>  78
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 2 for LIGCas-3 locus

<400>  78
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacggt gaggtatata       60

tatcctccgc cggggcacgt acggtacaat tcccag                                 96


<210>  79
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 3 for LIGCas-3 locus

<400>  79
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtactgt gaggtatata       60

tatcctccgc cggggcacgt acggtacaat tcccag                                 96


<210>  80
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 4 for LIGCas-3 locus

<400>  80
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg aggtatatat       60

atcctccgcc ggggcacgta cggtacaatt cccag                                  95


<210>  81
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 5 for LIGCas-3 locus

<400>  81
aaggcgcaaa tgagtagcag cgcacgtata tatatcctcc gccggggcac gtacggtaca       60

attcccag                                                                68


<210>  82
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 6 for LIGCas-3 locus

<400>  82
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cggtacaatt cccag            55


<210>  83
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 7 for LIGCas-3 locus

<400>  83
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtgtgag gtatatatat       60

cctccgccgg ggcacgtacg gtacaattcc cag                                    93


<210>  84
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 8 for LIGCas-3 locus

<400>  84
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgccggggca cgtacggtac       60

aattcccag                                                               69


<210>  85
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 9 for LIGCas-3 locus

<400>  85
aaggcgcaaa tgagtagcag cgcacgtata tatcctccgc cggggcacgt acggtacaat       60

tcccag                                                                  66


<210>  86
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 10 for LIGCas-3 locus

<400>  86
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtatgtg aggtatatat       60

atcctccgcc ggggcacgta cggtacaatt cccag                                  95


<210>  87
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 1 for LIG3-4 homing endonuclease locus

<400>  87
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg aggtatatat       60

atcctccgcc ggggcacgta cggtacaatt cccag                                  95


<210>  88
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 2 for LIG3-4 homing endonuclease locus

<400>  88
ccttcgcaaa tgagtagcag cgcacgtata tatatcctcc gccggggcac gtacggtaca       60

attcccag                                                                68


<210>  89
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 3 for LIG3-4 homing endonuclease locus

<400>  89
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgta cggtacaatt       60

cccag                                                                   65


<210>  90
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 4 for LIG3-4 homing endonuclease locus

<400>  90
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cggtacaatt cccag            55


<210>  91
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 5 for LIG3-4 homing endonuclease locus

<400>  91
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgccggggca cgtacggtac       60

aattcccag                                                               69


<210>  92
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 6 for LIG3-4 homing endonuclease locus

<400>  92
ccttcgcaaa tgagtagcag cgcacgtata tatacgtgtg aggtatatat atcctccgcc       60

ggggcacgta cggtacaatt cccag                                             85


<210>  93
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 7 for LIG3-4 homing endonuclease locus

<400>  93
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtgtgag gtatatatat       60

cctccgccgg ggcacgtacg gtacaattcc cag                                    93


<210>  94
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 8 for LIG3-4 homing endonuclease locus

<400>  94
ccttcgcaaa tgagtagcag cgcacgtata tatcctccgc cggggcacgt acggtacaat       60

tcccag                                                                  66


<210>  95
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 9 for LIG3-4 homing endonuclease locus

<400>  95
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg tggtatatat       60

atcctccgcc ggggcacgta cggtacaatt cccag                                  95


<210>  96
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 10 for LIG3-4 homing endonuclease locus

<400>  96
ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cggtatatat acgtgtgagg       60

tatatatatc ctccgccggg gcacgtacgg tacaattccc ag                         102


<210>  97
<211>  5424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  donor DNA -HR Repair DNA

<400>  97
cccatagaaa actgtgtgct ataatacacc aaaaggaaag caaagtgaaa aggaaacttt       60

gaatagccaa gaagactcgg agtgcttcac gccttcacct atcccacata ggtgatgagc      120

taagagtaaa atgtagattc tctcgagtac tgaatattgc ctgcactttt ccttgcagta      180

aatacacctt taatccatga cgagagtcca ctctttgagt ccgtcttgag attcttccat      240

tgatcataca acatgacctc gaagtcctga tggagaacaa cttatataat taaaactaca      300

atacagaaag ttcctgacaa ttaaaacctt tggtggtggc atgccgtagg ttaaaaaaaa      360

tagataatga caacacaact ggagacacgc tctttgccga gtgctcacac gtttgctgag      420

agcgagcact cggcaaatat atgatttgcc gaataccacc ctcctcggca aaacaataca      480

ctaggcaaaa aggtagtttc ccatcaccat gatgcccgcc gttaatgtac cttctatgcc      540

gagtatgttg gcgctcagca aagagatcgt taccggcgtt tgtttcacca agagctcttt      600

gacgagtgtg gcacacgaca aaaccttttg ccgagtgtaa ttagtcgttt gccaagtgac      660

tggtgcagtt ggcaaaggag tcgtttatta tgtgtgggca aaatgatata tggtgccagt      720

tagggctagc aaattaaagg gggggggggg ggggttaggt tgaagaaggt gacgagtaat      780

aaggtctcgg acggccgcgc gcatatatat cagatccgat ccaatggcac acggtgcaaa      840

cgaaaagcac gaaatttcca ccagcttaat tagggagaga aaaatagagc accagctgat      900

gagtgaatga atgagataga cgggacacag agggtccagc aggctagcct actctggccg      960

ccctaaatag aagtcagtgc cgtgacgacg cgcaaacttc ttttgatcgg ctgcggaaat     1020

aatatactgt aacgatttac gcacctgctg ggaattgtac cgtacgtgcc ccggcggagg     1080

atatatatac ctcacacaag ggcgaattgt actagttagt tagctagtcg gtcctagatg     1140

ccgtaatcat tagctaatcg taagtgacgc ttggacacga gcggcttgag ctaggaacct     1200

acgaagtcat cggaatcagc tcaggtgtac agaagttcct atactttctg gagaatagga     1260

acttcggaat aggaacttcg tatacgctag ggccgcattc gcaaaacaca cctagactag     1320

atttgttttg ctaacccaat tgatattaat tatatatgat taatatttat atgtatatgg     1380

atttggttaa tgaaatgcat ctggttcatc aaagaattat aaagacacgt gacattcatt     1440

taggataaga aatatggatg atctctttct cttttattca gataactagt aattacacat     1500

aacacacaac tttgatgccc acattatagt gattagcatg tcactatgtg tgcatccttt     1560

tatttcatac attaattaag ttggccaatc cagaagatgg acaagtctag gtttcgactc     1620

agatctgcgt caccgggcgc accgggcgcg gcggggccgg cagctcgaag tcgcgctgcc     1680

agaagccgac gtcgtgccag ccgccgtgct tgtagccggc ggcgcggagg gtgccgcggg     1740

cggtgtagcc gagggcctcg tggaggcgca cggacgggtc gttcgggagg ccgatcacgg     1800

ccaccacgga cttgaagccc tgggcctcca tgctcttgag gaggtgggtg tagagggtgg     1860

agccgaggcc gaggcgctgg tggcggtggg acacgtacac ggtggactcc acggtccagt     1920

cgtaggcgtt gcgggccttc cacgggccgg cgtaggcgat gccggccacc acgccctcca     1980

cctcggccac gagccacggg tagcggtcct ggaggcgctc caggtcgtcg atccactcct     2040

gcggggtctg cggctcggtg cggaagttca cggtggaggt ctcgatgtag tggttcacga     2100

tgtcgcacac ggcggccatg tcggcggcgg tggccgggcg gatctcgacg gggcggcgct     2160

cgggggacat ggtgtcgtgt ggatcccggt ggatctgaag ttcctatact ttctagagaa     2220

taggaacttc ggaataggaa cttcgctagc gaattgatcc tctagagtcg acctgcagaa     2280

gtaacaccaa acaacagggt gagcatcgac aaaagaaaca gtaccaagca aataaatagc     2340

gtatgaaggc agggctaaaa aaatccacat atagctgctg catatgccat catccaagta     2400

tatcaagatc aaaataatta taaaacatac ttgtttatta taatagatag gtactcaagg     2460

ttagagcata tgaatagatg ctgcatatgc catcatgtat atgcatcagt aaaacccaca     2520

tcaacatgta tacctatcct agatcgatat ttccatccat cttaaactcg taactatgaa     2580

gatgtatgac acacacatac agttccaaaa ttaataaata caccaggtag tttgaaacag     2640

tattctactc cgatctagaa cgaatgaacg accgcccaac cacaccacat catcacaacc     2700

aagcgaacaa aaagcatctc tgtatatgca tcagtaaaac ccgcatcaac atgtatacct     2760

atcctagatc gatatttcca tccatcatct tcaattcgta actatgaata tgtatggcac     2820

acacatacag atccaaaatt aataaatcca ccaggtagtt tgaaacagaa ttctactccg     2880

atctagaacg accgcccaac cagaccacat catcacaacc aagacaaaaa aaagcatgaa     2940

aagatgaccc gacaaacaag tgcacggcat atattgaaat aaaggaaaag ggcaaaccaa     3000

accctatgca acgaaacaaa aaaaatcatg aaatcgatcc cgtctgcgga acggctagag     3060

ccatcccagg attccccaaa gagaaacact ggcaagttag caatcagaac gtgtctgacg     3120

tacaggtcgc atccgtgtac gaacgctagc agcacggatc taacacaaac acggatctaa     3180

cacaaacatg aacagaagta gaactaccgg gccctaacca tgcatggacc ggaacgccga     3240

tctagagaag gtagagaggg ggggggggga ggacgagcgg cgtaccttga agcggaggtg     3300

ccgacgggtg gatttggggg agatctggtt gtgtgtgtgt gcgctccgaa caacacgagg     3360

ttggggaaag agggtgtgga gggggtgtct atttattacg gcgggcgagg aagggaaagc     3420

gaaggagcgg tgggaaagga atcccccgta gctgccggtg ccgtgagagg aggaggaggc     3480

cgcctgccgt gccggctcac gtctgccgct ccgccacgca atttctggat gccgacagcg     3540

gagcaagtcc aacggtggag cggaactctc gagaggggtc cagaggcagc gacagagatg     3600

ccgtgccgtc tgcttcgctt ggcccgacgc gacgctgctg gttcgctggt tggtgtccgt     3660

tagactcgtc gacggcgttt aacaggctgg cattatctac tcgaaacaag aaaaatgttt     3720

ccttagtttt tttaatttct taaagggtat ttgtttaatt tttagtcact ttattttatt     3780

ctattttata tctaaattat taaataaaaa aactaaaata gagttttagt tttcttaatt     3840

tagaggctaa aatagaataa aatagatgta ctaaaaaaat tagtctataa aaaccattaa     3900

ccctaaaccc taaatggatg tactaataaa atggatgaag tattatatag gtgaagctat     3960

ttgcaaaaaa aaaggagaac acatgcacac taaaaagata aaactgtaga gtcctgttgt     4020

caaaatactc aattgtcctt tagaccatgt ctaactgttc atttatatga ttctctaaaa     4080

cactgatatt attgtagtac tatagattat attattcgta gagtaaagtt taaatatatg     4140

tataaagata gataaactgc acttcaaaca agtgtgacaa aaaaaatatg tggtaatttt     4200

ttataactta gacatgcaat gctcattatc tctagagagg ggcacgaccg ggtcacgctg     4260

cactgcaggc tagcggcgaa ttcgcccttg tacgcgtacg cgtatatata cgtgcgctgc     4320

tactcatttg cgcgggaata cagctcagtc tgctgtgcgc tgcaggatgt acatacatac     4380

atgcgcaggt gcaaagtcta cgcgcgcggg caatgcaagc ccctggcgta gttgggccat     4440

gactgagatc acgcctcatg gtcatggaac gaaacaccgc gtccggccgg gctgcccctg     4500

gcgtcacgcg ggaggcagct gctagcgtta gcgtacgtac ccaccgtctc gtacacacca     4560

ccgcagggag agagaagagc gatgcaatgc acatgtacag catccgcatc atgcatagat     4620

actcatatct tcaaggccac acatgcagca gtgtcgtacg ctacgttgtt tcaacggagg     4680

aggaggatac atacatagac acccacagcc agcctagcat atagcagata gcatacggac     4740

tcccgggtga ggaaaaatgg agggcgaacc aaaccaacca caaagaagca gcagcagcag     4800

cagcagcagc tgcggctgct atcaccactc accaactcca attaaagatc tctctctctc     4860

tctctactgg ccggccctgt cagtgccagc gcccggtttg ttgctagctg agctgcgggc     4920

gtcgctctta gatatagccc aaaactcact ccaccaccac tcgttccatg gaaccctaga     4980

ccaaaagtac tcgcgctctc ggccctcgct ctcgccctct ccctctccgc agcaaaagag     5040

atccggccgg ccgagaaggg cgcgcgctag ctgcccggct actagctggc gcccgcccgc     5100

gcatatatct gtgtcatcgc catcacccac accatggccc ggccggccaa caccgccgta     5160

ttagctctgt ctgtcgctcg tccacctgcg accgactgag cgatcgatct ccaccgagct     5220

ctccgctaag cgctgtcctt gccgccgtcc tcccctccgt cccctacgca tccatttccg     5280

tgtgctcgtg tgtgcgcgcg cgggcactcc tgctcctgct ccctccggcc cctcctcccc     5340

tcccaggctc ccagctagcc gcgcccgccc gcgcgacctg cacctgcaca gatcgggcgg     5400

ccgggccgac cgatcgatcg agat                                            5424


<210>  98
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR primer

<400>  98
cccgttattg tatgaggtaa tgac                                              24


<210>  99
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR primer for site-specific transgene insertion at 
       junction 1

<400>  99
gctcgtgtcc aagcgtcact tacgattagc t                                      31


<210>  100
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR primer for site-specific transgene insertion at 
       junction 2

<400>  100
ccatgtctaa ctgttcattt atatgattct ct                                     32


<210>  101
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR primer for site-specific transgene insertion at 
       junction 2

<400>  101
gcagccgata ggttcatcat cttc                                              24


<210>  102
<211>  7850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linked Cas9 and LIGCas-3 long guide RNA expression cassettes

<400>  102
gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta       60

taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      120

atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      180

gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt      240

ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg      300

caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta      360

gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct      420

ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa      480

tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta      540

aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt      600

ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca      660

cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg      720

ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag      780

gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc      840

ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctttccc      900

caacctcgtg ttgttcggag cgcacacaca cacaaccaga tctcccccaa atccacccgt      960

cggcacctcc gcttcaaggt acgccgctcg tcctcccccc cccccctctc taccttctct     1020

agatcggcgt tccggtccat gcatggttag ggcccggtag ttctacttct gttcatgttt     1080

gtgttagatc cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct     1140

gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg aatcctggga     1200

tggctctagc cgttccgcag acgggatcga tttcatgatt ttttttgttt cgttgcatag     1260

ggtttggttt gcccttttcc tttatttcaa tatatgccgt gcacttgttt gtcgggtcat     1320

cttttcatgc ttttttttgt cttggttgtg atgatgtggt ctggttgggc ggtcgttcta     1380

gatcggagta gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg     1440

tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat atcgatctag     1500

gataggtata catgttgatg cgggttttac tgatgcatat acagagatgc tttttgttcg     1560

cttggttgtg atgatgtggt gtggttgggc ggtcgttcat tcgttctaga tcggagtaga     1620

atactgtttc aaactacctg gtgtatttat taattttgga actgtatgtg tgtgtcatac     1680

atcttcatag ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt     1740

tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat tcatatgctc     1800

taaccttgag tacctatcta ttataataaa caagtatgtt ttataattat tttgatcttg     1860

atatacttgg atgatggcat atgcagcagc tatatgtgga tttttttagc cctgccttca     1920

tacgctattt atttgcttgg tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt     1980

tacttctgca ggtcgactct agaggatcca tggcaccgaa gaagaagcgc aaggtgatgg     2040

acaagaagta cagcatcggc ctcgacatcg gcaccaactc ggtgggctgg gccgtcatca     2100

cggacgaata taaggtcccg tcgaagaagt tcaaggtcct cggcaataca gaccgccaca     2160

gcatcaagaa aaacttgatc ggcgccctcc tgttcgatag cggcgagacc gcggaggcga     2220

ccaggctcaa gaggaccgcc aggagacggt acactaggcg caagaacagg atctgctacc     2280

tgcaggagat cttcagcaac gagatggcga aggtggacga ctccttcttc caccgcctgg     2340

aggaatcatt cctggtggag gaggacaaga agcatgagcg gcacccaatc ttcggcaaca     2400

tcgtcgacga ggtaagtttc tgcttctacc tttgatatat atataataat tatcattaat     2460

tagtagtaat ataatatttc aaatattttt ttcaaaataa aagaatgtag tatatagcaa     2520

ttgcttttct gtagtttata agtgtgtata ttttaattta taacttttct aatatatgac     2580

caaaacatgg tgatgtgcag gtggcctacc acgagaagta cccgacaatc taccacctcc     2640

ggaagaaact ggtggacagc acagacaagg cggacctccg gctcatctac cttgccctcg     2700

cgcatatgat caagttccgc ggccacttcc tcatcgaggg cgacctgaac ccggacaact     2760

ccgacgtgga caagctgttc atccagctcg tgcagacgta caatcaactg ttcgaggaga     2820

accccataaa cgctagcggc gtggacgcca aggccatcct ctcggccagg ctctcgaaat     2880

caagaaggct ggagaacctt atcgcgcagt tgccaggcga aaagaagaac ggcctcttcg     2940

gcaaccttat tgcgctcagc ctcggcctga cgccgaactt caaatcaaac ttcgacctcg     3000

cggaggacgc caagctccag ctctcaaagg acacctacga cgacgacctc gacaacctcc     3060

tggcccagat aggagaccag tacgcggacc tcttcctcgc cgccaagaac ctctccgacg     3120

ctatcctgct cagcgacatc cttcgggtca acaccgaaat taccaaggca ccgctgtccg     3180

ccagcatgat taaacgctac gacgagcacc atcaggacct cacgctgctc aaggcactcg     3240

tccgccagca gctccccgag aagtacaagg agatcttctt cgaccaatca aaaaacggct     3300

acgcgggata tatcgacggc ggtgccagcc aggaagagtt ctacaagttc atcaaaccaa     3360

tcctggagaa gatggacggc accgaggagt tgctggtcaa gctcaacagg gaggacctcc     3420

tcaggaagca gaggaccttc gacaacggct ccatcccgca tcagatccac ctgggcgaac     3480

tgcatgccat cctgcggcgc caggaggact tctacccgtt cctgaaggat aaccgggaga     3540

agatcgagaa gatcttgacg ttccgcatcc catactacgt gggcccgctg gctcgcggca     3600

actcccggtt cgcctggatg acccggaagt cggaggagac catcacaccc tggaactttg     3660

aggaggtggt cgataagggc gctagcgctc agagcttcat cgagcgcatg accaacttcg     3720

ataaaaacct gcccaatgaa aaagtcctcc ccaagcactc gctgctctac gagtacttca     3780

ccgtgtacaa cgagctcacc aaggtcaaat acgtcaccga gggcatgcgg aagccggcgt     3840

tcctgagcgg cgagcagaag aaggcgatag tggacctcct cttcaagacc aacaggaagg     3900

tgaccgtgaa gcaattaaaa gaggactact tcaagaaaat agagtgcttc gactccgtgg     3960

agatctcggg cgtggaggat cggttcaacg cctcactcgg cacgtatcac gacctcctca     4020

agatcattaa agacaaggac ttcctcgaca acgaggagaa cgaggacatc ctcgaggaca     4080

tcgtcctcac cctgaccctg ttcgaggacc gcgaaatgat cgaggagagg ctgaagacct     4140

acgcgcacct gttcgacgac aaggtcatga aacagctcaa gaggcgccgc tacactggtt     4200

ggggaaggct gtcccgcaag ctcattaatg gcatcaggga caagcagagc ggcaagacca     4260

tcctggactt cctcaagtcc gacgggttcg ccaaccgcaa cttcatgcag ctcattcacg     4320

acgactcgct cacgttcaag gaagacatcc agaaggcaca ggtgagcggg cagggtgact     4380

ccctccacga acacatcgcc aacctggccg gctcgccggc cattaaaaag ggcatcctgc     4440

agacggtcaa ggtcgtcgac gagctcgtga aggtgatggg ccggcacaag cccgaaaata     4500

tcgtcataga gatggccagg gagaaccaga ccacccaaaa agggcagaag aactcgcgcg     4560

agcggatgaa acggatcgag gagggcatta aagagctcgg gtcccagatc ctgaaggagc     4620

accccgtgga aaatacccag ctccagaatg aaaagctcta cctctactac ctgcagaacg     4680

gccgcgacat gtacgtggac caggagctgg acattaatcg gctatcggac tacgacgtcg     4740

accacatcgt gccgcagtcg ttcctcaagg acgatagcat cgacaacaag gtgctcaccc     4800

ggtcggataa aaatcggggc aagagcgaca acgtgcccag cgaggaggtc gtgaagaaga     4860

tgaaaaacta ctggcgccag ctcctcaacg cgaaactgat cacccagcgc aagttcgaca     4920

acctgacgaa ggcggaacgc ggtggcttga gcgaactcga taaggcgggc ttcataaaaa     4980

ggcagctggt cgagacgcgc cagatcacga agcatgtcgc ccagatcctg gacagccgca     5040

tgaatactaa gtacgatgaa aacgacaagc tgatccggga ggtgaaggtg atcacgctga     5100

agtccaagct cgtgtcggac ttccgcaagg acttccagtt ctacaaggtc cgcgagatca     5160

acaactacca ccacgcccac gacgcctacc tgaatgcggt ggtcgggacc gccctgatca     5220

agaagtaccc gaagctggag tcggagttcg tgtacggcga ctacaaggtc tacgacgtgc     5280

gcaaaatgat cgccaagtcc gagcaggaga tcggcaaggc cacggcaaaa tacttcttct     5340

actcgaacat catgaacttc ttcaagaccg agatcaccct cgcgaacggc gagatccgca     5400

agcgcccgct catcgaaacc aacggcgaga cgggcgagat cgtctgggat aagggccggg     5460

atttcgcgac ggtccgcaag gtgctctcca tgccgcaagt caatatcgtg aaaaagacgg     5520

aggtccagac gggcgggttc agcaaggagt ccatcctccc gaagcgcaac tccgacaagc     5580

tcatcgcgag gaagaaggat tgggacccga aaaaatatgg cggcttcgac agcccgaccg     5640

tcgcatacag cgtcctcgtc gtggcgaagg tggagaaggg caagtcaaag aagctcaagt     5700

ccgtgaagga gctgctcggg atcacgatta tggagcggtc ctccttcgag aagaacccga     5760

tcgacttcct agaggccaag ggatataagg aggtcaagaa ggacctgatt attaaactgc     5820

cgaagtactc gctcttcgag ctggaaaacg gccgcaagag gatgctcgcc tccgcaggcg     5880

agttgcagaa gggcaacgag ctcgccctcc cgagcaaata cgtcaatttc ctgtacctcg     5940

ctagccacta tgaaaagctc aagggcagcc cggaggacaa cgagcagaag cagctcttcg     6000

tggagcagca caagcattac ctggacgaga tcatcgagca gatcagcgag ttctcgaagc     6060

gggtgatcct cgccgacgcg aacctggaca aggtgctgtc ggcatataac aagcaccgcg     6120

acaaaccaat acgcgagcag gccgaaaata tcatccacct cttcaccctc accaacctcg     6180

gcgctccggc agccttcaag tacttcgaca ccacgattga ccggaagcgg tacacgagca     6240

cgaaggaggt gctcgatgcg acgctgatcc accagagcat cacagggctc tatgaaacac     6300

gcatcgacct gagccagctg ggcggagaca agagaccacg ggaccgccac gatggcgagc     6360

tgggaggccg caagcgggca aggtaggtac cgttaaccta gacttgtcca tcttctggat     6420

tggccaactt aattaatgta tgaaataaaa ggatgcacac atagtgacat gctaatcact     6480

ataatgtggg catcaaagtt gtgtgttatg tgtaattact agttatctga ataaaagaga     6540

aagagatcat ccatatttct tatcctaaat gaatgtcacg tgtctttata attctttgat     6600

gaaccagatg catttcatta accaaatcca tatacatata aatattaatc atatataatt     6660

aatatcaatt gggttagcaa aacaaatcta gtctaggtgt gttttgcgaa tgcggccccc     6720

cctcgaggtc gacggtatcg ataagctttg agagtacaat gatgaaccta gattaatcaa     6780

tgccaaagtc tgaaaaatgc accctcagtc tatgatccag aaaatcaaga ttgcttgagg     6840

ccctgttcgg ttgttccgga ttagagcccc ggattaattc ctagccggat tacttctcta     6900

atttatatag attttgatga gctggaatga atcctggctt attccggtac aaccgaacag     6960

gccctgaagg ataccagtaa tcgctgagct aaattggcat gctgtcagag tgtcagtatt     7020

gcagcaaggt agtgagataa ccggcatcat ggtgccagtt tgatggcacc attagggtta     7080

gagatggtgg ccatgggcgc atgtcctggc caactttgta tgatatatgg cagggtgaat     7140

aggaaagtaa aattgtattg taaaaaggga tttcttctgt ttgttagcgc atgtacaagg     7200

aatgcaagtt ttgagcgagg gggcatcaaa gatctggctg tgtttccagc tgtttttgtt     7260

agccccatcg aatccttgac ataatgatcc cgcttaaata agcaacctcg cttgtatagt     7320

tccttgtgct ctaacacacg atgatgataa gtcgtaaaat agtggtgtcc aaagaatttc     7380

caggcccagt tgtaaaagct aaaatgctat tcgaatttct actagcagta agtcgtgttt     7440

agaaattatt tttttatata ccttttttcc ttctatgtac agtaggacac agtgtcagcg     7500

ccgcgttgac ggagaatatt tgcaaaaaag taaaagagaa agtcatagcg gcgtatgtgc     7560

caaaaacttc gtcacagaga gggccataag aaacatggcc cacggcccaa tacgaagcac     7620

cgcgacgaag cccaaacagc agtccgtagg tggagcaaag cgctgggtaa tacgcaaacg     7680

ttttgtccca ccttgactaa tcacaagagt ggagcgtacc ttataaaccg agccgcaagc     7740

accgaattgc gtacgcgtac gtgtggtttt agagctagaa atagcaagtt aaaataaggc     7800

tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg cttttttttt                7850


<210>  103
<211>  23
<212>  DNA
<213>  Zea mays

<400>  103
tgggcaggtc tcacgacggt tgg                                               23


<210>  104
<211>  91
<212>  DNA
<213>  Zea mays

<400>  104
ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacgacgg ttgggctgga       60

gagccggctg gtaggggagg acctcaacgg c                                      91


<210>  105
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 1 for 55CasRNA-1 locus

<400>  105
ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacgaggt tgggctggag       60

agccggctgg taggggagga cctcaacggc                                        90


<210>  106
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 2 for 55CasRNA-1 locus

<400>  106
ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacacggt tgggctggag       60

agccggctgg taggggagga cctcaacggc                                        90


<210>  107
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 3 for 55CasRNA-1 locus

<400>  107
ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacgacgg tttgggctgg       60

agagccggct ggtaggggag gacctcaacg gc                                     92


<210>  108
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 4 for 55CasRNA-1 locus

<400>  108
ccggtttcgc gtgctctggc tttacattgc atgagcaggt cgtgacggtt gggctggaga       60

gccggctggt aggggaggac ctcaacggc                                         89


<210>  109
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 5 for 55CasRNA-1 locus

<400>  109
gggcaggtct cgacggttgg gctggagagc cggctggtag gggaggacct caacggc          57


<210>  110
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation 6 for 55CasRNA-1 locus

<400>  110
ccggtttcgc gtgctcttgg gctggagagc cggctggtag gggaggacct caacggc          57


<210>  111
<211>  22
<212>  DNA
<213>  Zea mays

<400>  111
atatacctca cacgtacgcg ta                                                22


<210>  112
<211>  1053
<212>  DNA
<213>  Zea mays

<400>  112
atgaacacca agtacaacaa ggagttcctg ctctacctgg ccggcttcgt ggacggcgac       60

ggctccatca aggcgcagat caagccgaac cagtcctgca agttcaagca ccagctctcc      120

ctgaccttcc aggtgaccca gaagacgcag aggcgctggt tcctcgacaa gctggtcgac      180

gagatcgggg tgggctacgt ctacgaccgc gggtcggtgt ccgactacga gctctcccag      240

atcaagcccc tgcacaactt cctcacccag ctccagccgt tcctcaagct gaagcagaag      300

caggcgaacc tcgtcctgaa gatcatcgag cagctcccct cggccaagga gtccccggac      360

aagttcctgg aggtgtgcac gtgggtcgac cagatcgcgg ccctcaacga cagcaagacc      420

cgcaagacga cctcggagac ggtgcgggcg gtcctggact ccctcccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca actaagtcca aggaattcct gctctacctg      600

gccggcttcg tggacggcga cggctccatc atcgcgtcca tcaagccgcg ccagtgctac      660

aagttcaagc acgagctccg cctggagttc accgtgaccc agaagacgca gaggcgctgg      720

ttcctcgaca agctggtcga cgagatcggg gtgggctacg tctacgaccg cgggtcggtg      780

tccgactacc gcctctccca gatcaagccc ctgcacaact tcctcaccca gctccagccg      840

ttcctcaagc tgaagcagaa gcaggcgaac ctcgtcctga agatcatcga gcagctcccc      900

tcggccaagg agtccccgga caagttcctg gaggtgtgca cgtgggtcga ccagatcgcg      960

gccctcaacg acagcaagac ccgcaagacg acctcggaga cggtgcgggc ggtcctggac     1020

tccctcagcg agaagaagaa gtcgtccccc tga                                  1053


<210>  113
<211>  22
<212>  DNA
<213>  Zea mays

<400>  113
gatggtgacg tacgtgccct ac                                                22


<210>  114
<211>  1053
<212>  DNA
<213>  Zea mays

<400>  114
atgaacacca agtacaacaa ggagttcctc ctctacctgg caggtttcgt ggacggcgat       60

gggtctatca tcgcccagat taccccgcaa cagtcctaca agttcaagca cgccctgcgg      120

ctgaggttca cggtcactca gaagacgcag cgcaggtggt tcctcgataa gctggtcgac      180

gaaatcggag tcggcaaggt gcgggacagg ggctctgtca gcgactacat cctctcccag      240

aagaagccgc tccacaactt cctgacccag ctgcagccct tcctcaagct caagcagaag      300

caggccaacc tggtgctcaa gatcatcgag cagctgccat ctgccaagga gtcaccagac      360

aagttccttg aggtctgcac ctgggtcgat cagatcgctg ccctgaacga ctccaagacg      420

aggaagacca cctccgagac cgtcagggct gtgctggact cactcccagg atccgttggc      480

ggtctcagcc cttctcaggc tagctcggct gcttcctcag ccagcagctc acctggctcc      540

ggtatcagcg aggctctcag agcaggtgcc accaagtcca aggagttcct cctgtacctg      600

gcaggcttcg ttgacggcga cggctcgatc atggcgtcca ttaccccgaa ccagtcgtgt      660

aagttcaagc atcagctgcg cctgcgcttt accgtcacgc agaagaccca gaggcgctgg      720

ttcctggaca aactggtgga cgagatcggg gtcgggaagg tgtacgacag agggagcgtt      780

agcgactacc ggctgtccca gaagaagccg ctccacaact tcctgacgca gctccaaccc      840

ttcctgaagc tgaagcagaa gcaggcgaac cttgtgctga agatcattga gcagctgccg      900

agcgccaagg agagccctga caagttcctg gaggtctgca cctgggtcga ccagatcgct      960

gccctcaacg actccaagac caggaagacc acgagcgaga ccgttcgggc tgtcctggac     1020

agcctctccg agaagaagaa gtcgagcccg tag                                  1053


<210>  115
<211>  4104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  soybean codon optimized Cas9

<400>  115
atggacaaaa agtactcaat agggctcgac atagggacta actccgttgg atgggccgtc       60

atcaccgacg agtacaaggt gccctccaag aagttcaagg tgttgggaaa caccgacagg      120

cacagcataa agaagaattt gatcggtgcc ctcctcttcg actccggaga gaccgctgag      180

gctaccaggc tcaagaggac cgctagaagg cgctacacca gaaggaagaa cagaatctgc      240

tacctgcagg agatcttctc caacgagatg gccaaggtgg acgactcctt cttccaccgc      300

cttgaggaat cattcctggt ggaggaggat aaaaagcacg agagacaccc aatcttcggg      360

aacatcgtcg acgaggtggc ctaccatgaa aagtacccta ccatctacca cctgaggaag      420

aagctggtcg actctaccga caaggctgac ttgcgcttga tttacctggc tctcgctcac      480

atgataaagt tccgcggaca cttcctcatt gagggagacc tgaacccaga caactccgac      540

gtggacaagc tcttcatcca gctcgttcag acctacaacc agcttttcga ggagaaccca      600

atcaacgcca gtggagttga cgccaaggct atcctctctg ctcgtctgtc aaagtccagg      660

aggcttgaga acttgattgc ccagctgcct ggcgaaaaga agaacggact gttcggaaac      720

ttgatcgctc tctccctggg attgactccc aacttcaagt ccaacttcga cctcgccgag      780

gacgctaagt tgcagttgtc taaagacacc tacgacgatg acctcgacaa cttgctggcc      840

cagataggcg accaatacgc cgatctcttc ctcgccgcta agaacttgtc cgacgcaatc      900

ctgctgtccg acatcctgag agtcaacact gagattacca aagctcctct gtctgcttcc      960

atgattaagc gctacgacga gcaccaccaa gatctgaccc tgctcaaggc cctggtgaga     1020

cagcagctgc ccgagaagta caaggagatc tttttcgacc agtccaagaa cggctacgcc     1080

ggatacattg acggaggcgc ctcccaggaa gagttctaca agttcatcaa gcccatcctt     1140

gagaagatgg acggtaccga ggagctgttg gtgaagttga acagagagga cctgttgagg     1200

aagcagagaa ccttcgacaa cggaagcatc cctcaccaaa tccacctggg agagctccac     1260

gccatcttga ggaggcagga ggatttctat cccttcctga aggacaaccg cgagaagatt     1320

gagaagatct tgaccttcag aattccttac tacgtcgggc cactcgccag aggaaactct     1380

aggttcgcct ggatgacccg caaatctgaa gagaccatta ctccctggaa cttcgaggaa     1440

gtcgtggaca agggcgcttc cgctcagtct ttcatcgaga ggatgaccaa cttcgataaa     1500

aatctgccca acgagaaggt gctgcccaag cactccctgt tgtacgagta tttcacagtg     1560

tacaacgagc tcaccaaggt gaagtacgtc acagagggaa tgaggaagcc tgccttcttg     1620

tccggagagc agaagaaggc catcgtcgac ctgctcttca agaccaacag gaaggtgact     1680

gtcaagcagc tgaaggagga ctacttcaag aagatcgagt gcttcgactc cgtcgagatc     1740

tctggtgtcg aggacaggtt caacgcctcc cttgggactt accacgatct gctcaagatt     1800

attaaagaca aggacttcct ggacaacgag gagaacgagg acatccttga ggacatcgtg     1860

ctcaccctga ccttgttcga agacagggaa atgatcgaag agaggctcaa gacctacgcc     1920

cacctcttcg acgacaaggt gatgaaacag ctgaagagac gcagatatac cggctgggga     1980

aggctctccc gcaaattgat caacgggatc agggacaagc agtcagggaa gactatactc     2040

gacttcctga agtccgacgg attcgccaac aggaacttca tgcagctcat tcacgacgac     2100

tccttgacct tcaaggagga catccagaag gctcaggtgt ctggacaggg tgactccttg     2160

catgagcaca ttgctaactt ggccggctct cccgctatta agaagggcat tttgcagacc     2220

gtgaaggtcg ttgacgagct cgtgaaggtg atgggacgcc acaagccaga gaacatcgtt     2280

attgagatgg ctcgcgagaa ccaaactacc cagaaagggc agaagaattc ccgcgagagg     2340

atgaagcgca ttgaggaggg cataaaagag cttggctctc agatcctcaa ggagcacccc     2400

gtcgagaaca ctcagctgca gaacgagaag ctgtacctgt actacctcca aaacggaagg     2460

gacatgtacg tggaccagga gctggacatc aacaggttgt ccgactacga cgtcgaccac     2520

atcgtgcctc agtccttcct gaaggatgac tccatcgaca ataaagtgct gacacgctcc     2580

gataaaaata gaggcaagtc cgacaacgtc ccctccgagg aggtcgtgaa gaagatgaaa     2640

aactactgga gacagctctt gaacgccaag ctcatcaccc agcgtaagtt cgacaacctg     2700

actaaggctg agagaggagg attgtccgag ctcgataagg ccggattcat caagagacag     2760

ctcgtcgaaa cccgccaaat taccaagcac gtggcccaaa ttctggattc ccgcatgaac     2820

accaagtacg atgaaaatga caagctgatc cgcgaggtca aggtgatcac cttgaagtcc     2880

aagctggtct ccgacttccg caaggacttc cagttctaca aggtgaggga gatcaacaac     2940

taccaccacg cacacgacgc ctacctcaac gctgtcgttg gaaccgccct catcaaaaaa     3000

tatcctaagc tggagtctga gttcgtctac ggcgactaca aggtgtacga cgtgaggaag     3060

atgatcgcta agtctgagca ggagatcggc aaggccaccg ccaagtactt cttctactcc     3120

aacatcatga acttcttcaa gaccgagatc actctcgcca acggtgagat caggaagcgc     3180

ccactgatcg agaccaacgg tgagactgga gagatcgtgt gggacaaagg gagggatttc     3240

gctactgtga ggaaggtgct ctccatgcct caggtgaaca tcgtcaagaa gaccgaagtt     3300

cagaccggag gattctccaa ggagtccatc ctccccaaga gaaactccga caagctgatc     3360

gctagaaaga aagactggga ccctaagaag tacggaggct tcgattctcc taccgtggcc     3420

tactctgtgc tggtcgtggc caaggtggag aagggcaagt ccaagaagct gaaatccgtc     3480

aaggagctcc tcgggattac catcatggag aggagttcct tcgagaagaa ccctatcgac     3540

ttcctggagg ccaagggata taaagaggtg aagaaggacc tcatcatcaa gctgcccaag     3600

tactccctct tcgagttgga gaacggaagg aagaggatgc tggcttctgc cggagagttg     3660

cagaagggaa atgagctcgc ccttccctcc aagtacgtga acttcctgta cctcgcctct     3720

cactatgaaa agttgaaggg ctctcctgag gacaacgagc agaagcagct cttcgtggag     3780

cagcacaagc actacctgga cgaaattatc gagcagatct ctgagttctc caagcgcgtg     3840

atattggccg acgccaacct cgacaaggtg ctgtccgcct acaacaagca cagggataag     3900

cccattcgcg agcaggctga aaacattatc cacctgttta ccctcacaaa cttgggagcc     3960

cctgctgcct tcaagtactt cgacaccacc attgacagga agagatacac ctccaccaag     4020

gaggtgctcg acgcaacact catccaccaa tccatcaccg gcctctatga aacaaggatt     4080

gacttgtccc agctgggagg cgac                                            4104


<210>  116
<211>  1503
<212>  DNA
<213>  Glycine max

<400>  116
ccgggtttac ttattttgtg ggtatctata cttttattag atttttaatc aggctcctga       60

tttcttttta tttcgattga attcctgaac ttgtattatt cagtagatcg aataaattat      120

aaaaagataa aatcataaaa taatatttta tcctatcaat catattaaag caatgaatat      180

gtaaaattaa tcttatcttt attttaaaaa atcatatagg tttagtattt ttttaaaaat      240

aaagatagga ttagttttac tattcactgc ttattacttt taaaaaaatc ataaaggttt      300

agtatttttt taaaataaat ataggaatag ttttactatt cactgcttta atagaaaaat      360

agtttaaaat ttaagatagt tttaatccca gcatttgcca cgtttgaacg tgagccgaaa      420

cgatgtcgtt acattatctt aacctagctg aaacgatgtc gtcataatat cgccaaatgc      480

caactggact acgtcgaacc cacaaatccc acaaagcgcg tgaaatcaaa tcgctcaaac      540

cacaaaaaag aacaacgcgt ttgttacacg ctcaatccca cgcgagtaga gcacagtaac      600

cttcaaataa gcgaatgggg cataatcaga aatccgaaat aaacctaggg gcattatcgg      660

aaatgaaaag tagctcactc aatataaaaa tctaggaacc ctagttttcg ttatcactct      720

gtgctccctc gctctatttc tcagtctctg tgtttgcggc tgaggattcc gaacgagtga      780

ccttcttcgt ttctcgcaaa ggtaacagcc tctgctcttg tctcttcgat tcgatctatg      840

cctgtctctt atttacgatg atgtttcttc ggttatgttt ttttatttat gctttatgct      900

gttgatgttc ggttgtttgt ttcgctttgt ttttgtggtt cagtttttta ggattctttt      960

ggtttttgaa tcgattaatc ggaagagatt ttcgagttat ttggtgtgtt ggaggtgaat     1020

cttttttttg aggtcataga tctgttgtat ttgtgttata aacatgcgac tttgtatgat     1080

tttttacgag gttatgatgt tctggttgtt ttattatgaa tctgttgaga cagaaccatg     1140

atttttgttg atgttcgttt acactattaa aggtttgttt taacaggatt aaaagttttt     1200

taagcatgtt gaaggagtct tgtagatatg taaccgtcga tagttttttt gtgggtttgt     1260

tcacatgtta tcaagcttaa tcttttacta tgtatgcgac catatctgga tccagcaaag     1320

gcgatttttt aattccttgt gaaacttttg taatatgaag ttgaaatttt gttattggta     1380

aactataaat gtgtgaagtt ggagtatacc tttaccttct tatttggctt tgtgatagtt     1440

taatttatat gtattttgag ttctgacttg tatttctttg aattgattct agtttaagta     1500

atc                                                                   1503


<210>  117
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  linker SV40 NLS

<400>  117
tctagagccg atcccaagaa gaagagaaag gtg                                    33


<210>  118
<211>  1379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cas9 with a SV40 NLS

<400>  118

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  119
<211>  8519
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC782

<400>  119
ccgggtttac ttattttgtg ggtatctata cttttattag atttttaatc aggctcctga       60

tttcttttta tttcgattga attcctgaac ttgtattatt cagtagatcg aataaattat      120

aaaaagataa aatcataaaa taatatttta tcctatcaat catattaaag caatgaatat      180

gtaaaattaa tcttatcttt attttaaaaa atcatatagg tttagtattt ttttaaaaat      240

aaagatagga ttagttttac tattcactgc ttattacttt taaaaaaatc ataaaggttt      300

agtatttttt taaaataaat ataggaatag ttttactatt cactgcttta atagaaaaat      360

agtttaaaat ttaagatagt tttaatccca gcatttgcca cgtttgaacg tgagccgaaa      420

cgatgtcgtt acattatctt aacctagctg aaacgatgtc gtcataatat cgccaaatgc      480

caactggact acgtcgaacc cacaaatccc acaaagcgcg tgaaatcaaa tcgctcaaac      540

cacaaaaaag aacaacgcgt ttgttacacg ctcaatccca cgcgagtaga gcacagtaac      600

cttcaaataa gcgaatgggg cataatcaga aatccgaaat aaacctaggg gcattatcgg      660

aaatgaaaag tagctcactc aatataaaaa tctaggaacc ctagttttcg ttatcactct      720

gtgctccctc gctctatttc tcagtctctg tgtttgcggc tgaggattcc gaacgagtga      780

ccttcttcgt ttctcgcaaa ggtaacagcc tctgctcttg tctcttcgat tcgatctatg      840

cctgtctctt atttacgatg atgtttcttc ggttatgttt ttttatttat gctttatgct      900

gttgatgttc ggttgtttgt ttcgctttgt ttttgtggtt cagtttttta ggattctttt      960

ggtttttgaa tcgattaatc ggaagagatt ttcgagttat ttggtgtgtt ggaggtgaat     1020

cttttttttg aggtcataga tctgttgtat ttgtgttata aacatgcgac tttgtatgat     1080

tttttacgag gttatgatgt tctggttgtt ttattatgaa tctgttgaga cagaaccatg     1140

atttttgttg atgttcgttt acactattaa aggtttgttt taacaggatt aaaagttttt     1200

taagcatgtt gaaggagtct tgtagatatg taaccgtcga tagttttttt gtgggtttgt     1260

tcacatgtta tcaagcttaa tcttttacta tgtatgcgac catatctgga tccagcaaag     1320

gcgatttttt aattccttgt gaaacttttg taatatgaag ttgaaatttt gttattggta     1380

aactataaat gtgtgaagtt ggagtatacc tttaccttct tatttggctt tgtgatagtt     1440

taatttatat gtattttgag ttctgacttg tatttctttg aattgattct agtttaagta     1500

atccatggac aaaaagtact caatagggct cgacataggg actaactccg ttggatgggc     1560

cgtcatcacc gacgagtaca aggtgccctc caagaagttc aaggtgttgg gaaacaccga     1620

caggcacagc ataaagaaga atttgatcgg tgccctcctc ttcgactccg gagagaccgc     1680

tgaggctacc aggctcaaga ggaccgctag aaggcgctac accagaagga agaacagaat     1740

ctgctacctg caggagatct tctccaacga gatggccaag gtggacgact ccttcttcca     1800

ccgccttgag gaatcattcc tggtggagga ggataaaaag cacgagagac acccaatctt     1860

cgggaacatc gtcgacgagg tggcctacca tgaaaagtac cctaccatct accacctgag     1920

gaagaagctg gtcgactcta ccgacaaggc tgacttgcgc ttgatttacc tggctctcgc     1980

tcacatgata aagttccgcg gacacttcct cattgaggga gacctgaacc cagacaactc     2040

cgacgtggac aagctcttca tccagctcgt tcagacctac aaccagcttt tcgaggagaa     2100

cccaatcaac gccagtggag ttgacgccaa ggctatcctc tctgctcgtc tgtcaaagtc     2160

caggaggctt gagaacttga ttgcccagct gcctggcgaa aagaagaacg gactgttcgg     2220

aaacttgatc gctctctccc tgggattgac tcccaacttc aagtccaact tcgacctcgc     2280

cgaggacgct aagttgcagt tgtctaaaga cacctacgac gatgacctcg acaacttgct     2340

ggcccagata ggcgaccaat acgccgatct cttcctcgcc gctaagaact tgtccgacgc     2400

aatcctgctg tccgacatcc tgagagtcaa cactgagatt accaaagctc ctctgtctgc     2460

ttccatgatt aagcgctacg acgagcacca ccaagatctg accctgctca aggccctggt     2520

gagacagcag ctgcccgaga agtacaagga gatctttttc gaccagtcca agaacggcta     2580

cgccggatac attgacggag gcgcctccca ggaagagttc tacaagttca tcaagcccat     2640

ccttgagaag atggacggta ccgaggagct gttggtgaag ttgaacagag aggacctgtt     2700

gaggaagcag agaaccttcg acaacggaag catccctcac caaatccacc tgggagagct     2760

ccacgccatc ttgaggaggc aggaggattt ctatcccttc ctgaaggaca accgcgagaa     2820

gattgagaag atcttgacct tcagaattcc ttactacgtc gggccactcg ccagaggaaa     2880

ctctaggttc gcctggatga cccgcaaatc tgaagagacc attactccct ggaacttcga     2940

ggaagtcgtg gacaagggcg cttccgctca gtctttcatc gagaggatga ccaacttcga     3000

taaaaatctg cccaacgaga aggtgctgcc caagcactcc ctgttgtacg agtatttcac     3060

agtgtacaac gagctcacca aggtgaagta cgtcacagag ggaatgagga agcctgcctt     3120

cttgtccgga gagcagaaga aggccatcgt cgacctgctc ttcaagacca acaggaaggt     3180

gactgtcaag cagctgaagg aggactactt caagaagatc gagtgcttcg actccgtcga     3240

gatctctggt gtcgaggaca ggttcaacgc ctcccttggg acttaccacg atctgctcaa     3300

gattattaaa gacaaggact tcctggacaa cgaggagaac gaggacatcc ttgaggacat     3360

cgtgctcacc ctgaccttgt tcgaagacag ggaaatgatc gaagagaggc tcaagaccta     3420

cgcccacctc ttcgacgaca aggtgatgaa acagctgaag agacgcagat ataccggctg     3480

gggaaggctc tcccgcaaat tgatcaacgg gatcagggac aagcagtcag ggaagactat     3540

actcgacttc ctgaagtccg acggattcgc caacaggaac ttcatgcagc tcattcacga     3600

cgactccttg accttcaagg aggacatcca gaaggctcag gtgtctggac agggtgactc     3660

cttgcatgag cacattgcta acttggccgg ctctcccgct attaagaagg gcattttgca     3720

gaccgtgaag gtcgttgacg agctcgtgaa ggtgatggga cgccacaagc cagagaacat     3780

cgttattgag atggctcgcg agaaccaaac tacccagaaa gggcagaaga attcccgcga     3840

gaggatgaag cgcattgagg agggcataaa agagcttggc tctcagatcc tcaaggagca     3900

ccccgtcgag aacactcagc tgcagaacga gaagctgtac ctgtactacc tccaaaacgg     3960

aagggacatg tacgtggacc aggagctgga catcaacagg ttgtccgact acgacgtcga     4020

ccacatcgtg cctcagtcct tcctgaagga tgactccatc gacaataaag tgctgacacg     4080

ctccgataaa aatagaggca agtccgacaa cgtcccctcc gaggaggtcg tgaagaagat     4140

gaaaaactac tggagacagc tcttgaacgc caagctcatc acccagcgta agttcgacaa     4200

cctgactaag gctgagagag gaggattgtc cgagctcgat aaggccggat tcatcaagag     4260

acagctcgtc gaaacccgcc aaattaccaa gcacgtggcc caaattctgg attcccgcat     4320

gaacaccaag tacgatgaaa atgacaagct gatccgcgag gtcaaggtga tcaccttgaa     4380

gtccaagctg gtctccgact tccgcaagga cttccagttc tacaaggtga gggagatcaa     4440

caactaccac cacgcacacg acgcctacct caacgctgtc gttggaaccg ccctcatcaa     4500

aaaatatcct aagctggagt ctgagttcgt ctacggcgac tacaaggtgt acgacgtgag     4560

gaagatgatc gctaagtctg agcaggagat cggcaaggcc accgccaagt acttcttcta     4620

ctccaacatc atgaacttct tcaagaccga gatcactctc gccaacggtg agatcaggaa     4680

gcgcccactg atcgagacca acggtgagac tggagagatc gtgtgggaca aagggaggga     4740

tttcgctact gtgaggaagg tgctctccat gcctcaggtg aacatcgtca agaagaccga     4800

agttcagacc ggaggattct ccaaggagtc catcctcccc aagagaaact ccgacaagct     4860

gatcgctaga aagaaagact gggaccctaa gaagtacgga ggcttcgatt ctcctaccgt     4920

ggcctactct gtgctggtcg tggccaaggt ggagaagggc aagtccaaga agctgaaatc     4980

cgtcaaggag ctcctcggga ttaccatcat ggagaggagt tccttcgaga agaaccctat     5040

cgacttcctg gaggccaagg gatataaaga ggtgaagaag gacctcatca tcaagctgcc     5100

caagtactcc ctcttcgagt tggagaacgg aaggaagagg atgctggctt ctgccggaga     5160

gttgcagaag ggaaatgagc tcgcccttcc ctccaagtac gtgaacttcc tgtacctcgc     5220

ctctcactat gaaaagttga agggctctcc tgaggacaac gagcagaagc agctcttcgt     5280

ggagcagcac aagcactacc tggacgaaat tatcgagcag atctctgagt tctccaagcg     5340

cgtgatattg gccgacgcca acctcgacaa ggtgctgtcc gcctacaaca agcacaggga     5400

taagcccatt cgcgagcagg ctgaaaacat tatccacctg tttaccctca caaacttggg     5460

agcccctgct gccttcaagt acttcgacac caccattgac aggaagagat acacctccac     5520

caaggaggtg ctcgacgcaa cactcatcca ccaatccatc accggcctct atgaaacaag     5580

gattgacttg tcccagctgg gaggcgactc tagagccgat cccaagaaga agagaaaggt     5640

gtaggttaac ctagacttgt ccatcttctg gattggccaa cttaattaat gtatgaaata     5700

aaaggatgca cacatagtga catgctaatc actataatgt gggcatcaaa gttgtgtgtt     5760

atgtgtaatt actagttatc tgaataaaag agaaagagat catccatatt tcttatccta     5820

aatgaatgtc acgtgtcttt ataattcttt gatgaaccag atgcatttca ttaaccaaat     5880

ccatatacat ataaatatta atcatatata attaatatca attgggttag caaaacaaat     5940

ctagtctagg tgtgttttgc gaatgcggcc gctcgagggg gggcccggta ccggcgcgcc     6000

gttctatagt gtcacctaaa tcgtatgtgt atgatacata aggttatgta ttaattgtag     6060

ccgcgttcta acgacaatat gtccatatgg tgcactctca gtacaatctg ctctgatgcc     6120

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     6180

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     6240

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     6300

ttataggtta atgtcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     6360

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     6420

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     6480

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt     6540

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     6600

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     6660

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     6720

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     6780

cattgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     6840

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     6900

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     6960

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     7020

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt     7080

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca     7140

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg     7200

attcattaat gcaggttgat cagatctcga tcccgcgaaa ttaatacgac tcactatagg     7260

gagaccacaa cggtttccct ctagaaataa ttttgtttaa ctttaagaag gagatatacc     7320

catggaaaag cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga     7380

cagcgtctcc gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga     7440

tgtaggaggg cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga     7500

tcgttatgtt tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat     7560

tggggaattc agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt     7620

gcaagacctg cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggctatgga     7680

tgcgatcgct gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg     7740

aatcggtcaa tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta     7800

tcactggcaa actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga     7860

gctgatgctt tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg     7920

ctccaacaat gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc     7980

gatgttcggg gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc     8040

ttgtatggag cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc     8100

gcggctccgg gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga     8160

cggcaatttc gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg     8220

agccgggact gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg     8280

ctgtgtagaa gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cgagggcaaa     8340

ggaatagtga ggtacagctt ggatcgatcc ggctgctaac aaagcccgaa aggaagctga     8400

gttggctgct gccaccgctg agcaataact agcataaccc cttggggcct ctaaacgggt     8460

cttgaggggt tttttgctga aaggaggaac tatatccgga tgatcgggcg cgccggtac      8519


<210>  120
<211>  434
<212>  DNA
<213>  Glycine max

<400>  120
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaa                                                        434


<210>  121
<211>  104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guide RNA for DD43CR1

<400>  121
gtcccttgta cttgtacgta gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttt                       104


<210>  122
<211>  3098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC783

<400>  122
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg tcccttgtac ttgtacgtag ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg ctcgaggggg ggcccggtac cggcgcgccg ttctatagtg tcacctaaat      600

cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa cgacaatatg      660

tccatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga      720

cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac      780

agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg      840

aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgacc      900

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa      960

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     1020

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     1080

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     1140

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     1200

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     1260

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     1320

cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt     1380

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     1440

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     1500

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     1560

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     1620

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     1680

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     1740

cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg caggttgatc     1800

agatctcgat cccgcgaaat taatacgact cactataggg agaccacaac ggtttccctc     1860

tagaaataat tttgtttaac tttaagaagg agatataccc atggaaaagc ctgaactcac     1920

cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac agcgtctccg acctgatgca     1980

gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat gtaggagggc gtggatatgt     2040

cctgcgggta aatagctgcg ccgatggttt ctacaaagat cgttatgttt atcggcactt     2100

tgcatcggcc gcgctcccga ttccggaagt gcttgacatt ggggaattca gcgagagcct     2160

gacctattgc atctcccgcc gtgcacaggg tgtcacgttg caagacctgc ctgaaaccga     2220

actgcccgct gttctgcagc cggtcgcgga ggctatggat gcgatcgctg cggccgatct     2280

tagccagacg agcgggttcg gcccattcgg accgcaagga atcggtcaat acactacatg     2340

gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat cactggcaaa ctgtgatgga     2400

cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag ctgatgcttt gggccgagga     2460

ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc tccaacaatg tcctgacgga     2520

caatggccgc ataacagcgg tcattgactg gagcgaggcg atgttcgggg attcccaata     2580

cgaggtcgcc aacatcttct tctggaggcc gtggttggct tgtatggagc agcagacgcg     2640

ctacttcgag cggaggcatc cggagcttgc aggatcgccg cggctccggg cgtatatgct     2700

ccgcattggt cttgaccaac tctatcagag cttggttgac ggcaatttcg atgatgcagc     2760

ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga gccgggactg tcgggcgtac     2820

acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc tgtgtagaag tactcgccga     2880

tagtggaaac cgacgcccca gcactcgtcc gagggcaaag gaatagtgag gtacagcttg     2940

gatcgatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga     3000

gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa     3060

aggaggaact atatccggat gatcgggcgc gccggtac                             3098


<210>  123
<211>  9093
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC815

<400>  123
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg tcccttgtac ttgtacgtag ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggacaa aaagtactca atagggctcg acatagggac     2100

taactccgtt ggatgggccg tcatcaccga cgagtacaag gtgccctcca agaagttcaa     2160

ggtgttggga aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt     2220

cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac     2280

cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga tggccaaggt     2340

ggacgactcc ttcttccacc gccttgagga atcattcctg gtggaggagg ataaaaagca     2400

cgagagacac ccaatcttcg ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc     2460

taccatctac cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt     2520

gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga     2580

cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc agacctacaa     2640

ccagcttttc gaggagaacc caatcaacgc cagtggagtt gacgccaagg ctatcctctc     2700

tgctcgtctg tcaaagtcca ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa     2760

gaagaacgga ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa     2820

gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga     2880

tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct tcctcgccgc     2940

taagaacttg tccgacgcaa tcctgctgtc cgacatcctg agagtcaaca ctgagattac     3000

caaagctcct ctgtctgctt ccatgattaa gcgctacgac gagcaccacc aagatctgac     3060

cctgctcaag gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga     3120

ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta     3180

caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt tggtgaagtt     3240

gaacagagag gacctgttga ggaagcagag aaccttcgac aacggaagca tccctcacca     3300

aatccacctg ggagagctcc acgccatctt gaggaggcag gaggatttct atcccttcct     3360

gaaggacaac cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg     3420

gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat     3480

tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt ctttcatcga     3540

gaggatgacc aacttcgata aaaatctgcc caacgagaag gtgctgccca agcactccct     3600

gttgtacgag tatttcacag tgtacaacga gctcaccaag gtgaagtacg tcacagaggg     3660

aatgaggaag cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt     3720

caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga     3780

gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct cccttgggac     3840

ttaccacgat ctgctcaaga ttattaaaga caaggacttc ctggacaacg aggagaacga     3900

ggacatcctt gaggacatcg tgctcaccct gaccttgttc gaagacaggg aaatgatcga     3960

agagaggctc aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag     4020

acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa     4080

gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca acaggaactt     4140

catgcagctc attcacgacg actccttgac cttcaaggag gacatccaga aggctcaggt     4200

gtctggacag ggtgactcct tgcatgagca cattgctaac ttggccggct ctcccgctat     4260

taagaagggc attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg     4320

ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg     4380

gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag agcttggctc     4440

tcagatcctc aaggagcacc ccgtcgagaa cactcagctg cagaacgaga agctgtacct     4500

gtactacctc caaaacggaa gggacatgta cgtggaccag gagctggaca tcaacaggtt     4560

gtccgactac gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga     4620

caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga     4680

ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca agctcatcac     4740

ccagcgtaag ttcgacaacc tgactaaggc tgagagagga ggattgtccg agctcgataa     4800

ggccggattc atcaagagac agctcgtcga aacccgccaa attaccaagc acgtggccca     4860

aattctggat tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt     4920

caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta     4980

caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca acgctgtcgt     5040

tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct gagttcgtct acggcgacta     5100

caaggtgtac gacgtgagga agatgatcgc taagtctgag caggagatcg gcaaggccac     5160

cgccaagtac ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc     5220

caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt     5280

gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa     5340

catcgtcaag aagaccgaag ttcagaccgg aggattctcc aaggagtcca tcctccccaa     5400

gagaaactcc gacaagctga tcgctagaaa gaaagactgg gaccctaaga agtacggagg     5460

cttcgattct cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa     5520

gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc     5580

cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg tgaagaagga     5640

cctcatcatc aagctgccca agtactccct cttcgagttg gagaacggaa ggaagaggat     5700

gctggcttct gccggagagt tgcagaaggg aaatgagctc gcccttccct ccaagtacgt     5760

gaacttcctg tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga     5820

gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat     5880

ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg tgctgtccgc     5940

ctacaacaag cacagggata agcccattcg cgagcaggct gaaaacatta tccacctgtt     6000

taccctcaca aacttgggag cccctgctgc cttcaagtac ttcgacacca ccattgacag     6060

gaagagatac acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac     6120

cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc     6180

caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga ttggccaact     6240

taattaatgt atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg     6300

gcatcaaagt tgtgtgttat gtgtaattac tagttatctg aataaaagag aaagagatca     6360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat     6420

gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat taatatcaat     6480

tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc aagcttatcg     6540

ataccgtcga gggggggccc ggtaccggcg cgccgttcta tagtgtcacc taaatcgtat     6600

gtgtatgata cataaggtta tgtattaatt gtagccgcgt tctaacgaca atatgtccat     6660

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     6720

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6780

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6840

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgaccaaaat     6900

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6960

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     7020

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     7080

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     7140

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     7200

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     7260

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     7320

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     7380

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     7440

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     7500

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     7560

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     7620

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     7680

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     7740

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcaggt tgatcagatc     7800

tcgatcccgc gaaattaata cgactcacta tagggagacc acaacggttt ccctctagaa     7860

ataattttgt ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga     7920

cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct     7980

cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga tatgtcctgc     8040

gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg cactttgcat     8100

cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag agcctgacct     8160

attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc     8220

ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc     8280

agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact acatggcgtg     8340

atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg atggacgaca     8400

ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc gaggactgcc     8460

ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg     8520

gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg     8580

tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag acgcgctact     8640

tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat atgctccgca     8700

ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat gcagcttggg     8760

cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa     8820

tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg     8880

gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca gcttggatcg     8940

atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat     9000

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag     9060

gaactatatc cggatgatcg ggcgcgccgg tac                                  9093


<210>  124
<211>  4107
<212>  DNA
<213>  S. pyogenes

<400>  124
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg attataaggt tccgtctaaa aagctcaagg gtctgggaaa tacagaccgc      120

cacggtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggcag attctactga taaagtggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggatt gtttgggaat      720

ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctact      900

ttactttcag atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca      960

atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gcgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccctatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaagt caaatatgtt actgagggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaacgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgtgagcgt     2340

atgaaacgta ttgaagaagg aataaaagaa ctaggaagtg atattctaaa ggagtatcct     2400

gttgaaaaca ctcaattaca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acaaaagctg aacgtggagg tttgagtgaa cttgataaag ttggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta gagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatcttaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca ggaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aataatggaa agaagctctt ttgaaaaaga tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt agaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaattg     3660

caaaaaggaa atgagctagc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  125
<211>  20
<212>  DNA
<213>  Glycine max

<400>  125
ggaactgaca cacgacatga                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Glycine max

<400>  126
gacatgatgg aacgtgacta                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Glycine max

<400>  127
gtcccttgta cttgtacgta                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Glycine max

<400>  128
gtattctaga aaagaggaat                                                   20


<210>  129
<211>  70
<212>  DNA
<213>  Glycine max

<400>  129
atcaaaattc ggaactgaca cacgacatga tggaacgtga ctaaggtggg tttttgactt       60

tgcatgtcga                                                              70


<210>  130
<211>  70
<212>  DNA
<213>  Glycine max

<400>  130
tcgacatgca aagtcaaaaa cccaccttag tcacgttcca tcatgtcgtg tgtcagttcc       60

gaattttgat                                                              70


<210>  131
<211>  70
<212>  DNA
<213>  Glycine max

<400>  131
ggcagactcc aattcctctt ttctagaata ccctccgtac gtacaagtac aagggacttg       60

tgagttgtaa                                                              70


<210>  132
<211>  70
<212>  DNA
<213>  Glycine max

<400>  132
ttacaactca caagtccctt gtacttgtac gtacggaggg tattctagaa aagaggaatt       60

ggagtctgcc                                                              70


<210>  133
<211>  71
<212>  DNA
<213>  Glycine max

<400>  133
ctacactctt tccctacacg acgctcttcc gatctggaat ttacagcaca agtagatcac       60

ttgtacttat c                                                            71


<210>  134
<211>  59
<212>  DNA
<213>  Glycine max

<400>  134
caagcagaag acggcatacg agctcttccg atctaaatca ctctcacttc gacatgcaa        59


<210>  135
<211>  71
<212>  DNA
<213>  Glycine max

<400>  135
ctacactctt tccctacacg acgctcttcc gatctttcct ttacagcaca agtagatcac       60

ttgtacttat c                                                            71


<210>  136
<211>  68
<212>  DNA
<213>  Glycine max

<400>  136
ctacactctt tccctacacg acgctcttcc gatctagctg taaatacagc cttacaactc       60

acaagtcc                                                                68


<210>  137
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer, DD43-A

<400>  137
caagcagaag acggcatacg agctcttccg atctttaatt taggactaaa agaagaggca       60

gac                                                                     63


<210>  138
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer, DD43-S4

<400>  138
ctacactctt tccctacacg acgctcttcc gatctctagg taaatacagc cttacaactc       60

acaagtcc                                                                68


<210>  139
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer, DD43-S5

<400>  139
ctacactctt tccctacacg acgctcttcc gatctgatcg taaatacagc cttacaactc       60

acaagtcc                                                                68


<210>  140
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer, JKY557

<400>  140
aatgatacgg cgaccaccga gatctacact ctttccctac acg                         43


<210>  141
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, JKY558

<400>  141
caagcagaag acggcata                                                     18


<210>  142
<211>  117
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 PCR amplicon

<400>  142
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg tgactaaggt gggtttttga ctttgcatgt cgaagtgaga gtgattt         117


<210>  143
<211>  117
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 PCR amplicon

<400>  143
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg tgactaaggt gggtttttga ctttgcatgt cgaagtgaga gtgattt         117


<210>  144
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 PCR amplicon

<400>  144
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa                   108


<210>  145
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 PCR amplicon

<400>  145
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa                   108


<210>  146
<211>  108
<212>  DNA
<213>  artificial sequence

<220>
<223>  amplicon

<400>  146
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa                   108


<210>  147
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  147
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgatg       60

atggaacgtg actaaggtgg gtttttgact ttgcatgtcg a                          101


<210>  148
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  148
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgatg       60

gaacgtgact aaggtgggtt tttgactttg catgtcgaag t                          101


<210>  149
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  149
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgact       60

gatggaacgt gactaaggtg ggtttttgac tttgcatgtc g                          101


<210>  150
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  150
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacatgg       60

aacgtgacta aggtgggttt ttgactttgc atgtcgaagt g                          101


<210>  151
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  151
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacatgatg       60

gaacgtgact aaggtgggtt tttgactttg catgtcgaag t                          101


<210>  152
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  152
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacagacat       60

gatggaacgt gactaaggtg ggtttttgac tttgcatgtc g                          101


<210>  153
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  153
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacgacatg       60

atggaacgtg actaaggtgg gtttttgact ttgcatgtcg a                          101


<210>  154
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site i

<400>  154
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacaagaaa       60

tgatggaacg tgactaaggt gggtttttga ctttgcatgt c                          101


<210>  155
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  155
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgatt       60

gaacgtgact aaggtgggtt tttgactttg catgtcgaag t                          101


<210>  156
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR1 mutant target site

<400>  156
ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacattg       60

aacgtgacta aggtgggttt ttgactttgc atgtcgaagt g                          101


<210>  157
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  157
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg tctaaggtgg gtttttgact ttgcatgtcg a                          101


<210>  158
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  158
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacc taaggtgggt ttttgacttt gcatgtcgaa g                          101


<210>  159
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  159
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg tgactaggtg ggtttttgac tttgcatgtc g                          101


<210>  160
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  160
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaact aaggtgggtt tttgactttg catgtcgaag t                          101


<210>  161
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  161
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg aaggtgggtt tttgactttg catgtcgaag t                          101


<210>  162
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  162
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaagg tgggtttttg actttgcatg tcgaagtgag a                          101


<210>  163
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site i

<400>  163
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggacgt gactaaggtg ggtttttgac tttgcatgtc g                          101


<210>  164
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  164
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaact ttactaaggt gggtttttga ctttgcatgt c                          101


<210>  165
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  165
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacacgaca       60

tgatggaacg tgacaaggtg ggtttttgac tttgcatgtc g                          101


<210>  166
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20CR2 mutant target site

<400>  166
ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg acacactaca       60

ttatttaact ttactaaggt gggtttttga ctttgcatgt c                          101


<210>  167
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  167
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa                   108


<210>  168
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  168
agctgtaaat acagccttac aactcacaag tcccttgtac ggagggtatt ctagaaaaga       60

ggaattggag tctgcctctt cttttagtcc taaattaaag a                          101


<210>  169
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  169
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacggag ggtattctag       60

aaaagaggaa ttggagtctg cctcttcttt tagtcctaaa t                          101


<210>  170
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  170
agctgtaaat acagccttac aactcacaag tcccttacgg agggtattct agaaaagagg       60

aattggagtc tgcctcttct tttagtccta aattaaagat c                          101


<210>  171
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  171
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtaccgta cggagggtat       60

tctagaaaag aggaattgga gtctgcctct tcttttagtc c                          101


<210>  172
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  172
agctgtaaat acagccttac aactcacaag tcccttgtac tgtacggagg gtattctaga       60

aaagaggaat tggagtctgc ctcttctttt agtcctaaat t                          101


<210>  173
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  173
agctgtaaat acagccttac aactcacaag tcccttgtag tacggagggt attctagaaa       60

agaggaattg gagtctgcct cttcttttag tcctaaatta a                          101


<210>  174
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  174
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtag ggtattctag       60

aaaagaggaa ttggagtctg cctcttcttt tagtcctaaa t                          101


<210>  175
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  175
agctgtaaat acagccttac aactcacaag tcctacactc tttccctaca cgacgctctt       60

cttttagtcc taaattaaag atcggaagat ctcgtatgcc                            100


<210>  176
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR1 mutant target site

<400>  176
agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacctta cggagggtat       60

tctagaaaag aggaattgga gtctgcctct tcttttagtc c                          101


<210>  177
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  177
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaatt ggagtctgcc tcttctttta gtcctaaatt a                          101


<210>  178
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  178
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga attggagtct gcctcttctt ttagtcctaa a                          101


<210>  179
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  179
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaattgg agtctgcctc ttcttttagt cctaaattaa a                          101


<210>  180
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  180
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga aattggagtc tgcctcttct tttagtccta a                          101


<210>  181
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  181
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaat tggagtctgc ctcttctttt agtcctaaat t                          101


<210>  182
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  182
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggattggagt ctgcctcttc ttttagtcct a                          101


<210>  183
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  183
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaattg gagtctgcct cttcttttag tcctaaatta a                          101


<210>  184
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  184
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctattggagt ctgcctcttc ttttagtcct aaattaaaga t                          101


<210>  185
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  185
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagtctgcc tcttctttta gtcctaaatt aaagatcgga a                          101


<210>  186
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  186
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaagt ctgcctcttc ttttagtcct aaattaaaga t                          101


<210>  187
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  187
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga gaattggagt ctgcctcttc ttttagtcct a                          101


<210>  188
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  188
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggagtctgcc tcttctttta gtcctaaatt a                          101


<210>  189
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  189
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctaattggag tctgcctctt cttttagtcc taaattaaag a                          101


<210>  190
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  190
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaaaga ggaaattgga gtctgcctct tcttttagtc c                          101


<210>  191
<211>  101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43CR2 mutant target site

<400>  191
ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt       60

ctagaaagag gaattggagt ctgcctcttc ttttagtcct a                          101


<210>  192
<211>  1377
<212>  PRT
<213>  Artificial sequence

<220>
<223>  maize optimized moCAS9 endonuclease

<400>  192

Met Ala Pro Lys Lys Lys Arg Lys Val Met Asp Lys Lys Tyr Ser Ile 
1               5                   10                  15      


Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            20                  25                  30          


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
        35                  40                  45              


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
    50                  55                  60                  


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
65                  70                  75                  80  


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
                85                  90                  95      


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
            100                 105                 110         


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
        115                 120                 125             


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
145                 150                 155                 160 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                165                 170                 175     


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
            180                 185                 190         


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
        195                 200                 205             


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
    210                 215                 220                 


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
225                 230                 235                 240 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
                245                 250                 255     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
            260                 265                 270         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
        275                 280                 285             


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
    290                 295                 300                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
305                 310                 315                 320 


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
                325                 330                 335     


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
            340                 345                 350         


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
    370                 375                 380                 


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
385                 390                 395                 400 


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
            420                 425                 430         


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
        435                 440                 445             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    450                 455                 460                 


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
465                 470                 475                 480 


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
                485                 490                 495     


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
            500                 505                 510         


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
    530                 535                 540                 


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
545                 550                 555                 560 


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
                565                 570                 575     


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
            580                 585                 590         


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
        595                 600                 605             


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
    610                 615                 620                 


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
                645                 650                 655     


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
        675                 680                 685             


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
    690                 695                 700                 


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
705                 710                 715                 720 


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
                725                 730                 735     


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
            740                 745                 750         


Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys 
    770                 775                 780                 


Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1070                 1075                 1080             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1175                 1180                 1185             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1190                 1195                 1200             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1250                 1255                 1260             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1265                 1270                 1275             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1295                 1300                 1305             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1310                 1315                 1320             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1325                 1330                 1335             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1370                 1375         


<210>  193
<211>  6677
<212>  DNA
<213>  Artificial sequence

<220>
<223>  maize optimized moCAS9 endonuclease

<400>  193
ctgcagtgca gcgtgacccg gtcgtgcccc tctctagaga taatgagcat tgcatgtcta       60

agttataaaa aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta      120

tctttataca tatatttaaa ctttactcta cgaataatat aatctatagt actacaataa      180

tatcagtgtt ttagagaatc atataaatga acagttagac atggtctaaa ggacaattga      240

gtattttgac aacaggactc tacagtttta tctttttagt gtgcatgtgt tctccttttt      300

ttttgcaaat agcttcacct atataatact tcatccattt tattagtaca tccatttagg      360

gtttagggtt aatggttttt atagactaat ttttttagta catctatttt attctatttt      420

agcctctaaa ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata      480

taaaatagaa taaaataaag tgactaaaaa ttaaacaaat accctttaag aaattaaaaa      540

aactaaggaa acatttttct tgtttcgagt agataatgcc agcctgttaa acgccgtcga      600

cgagtctaac ggacaccaac cagcgaacca gcagcgtcgc gtcgggccaa gcgaagcaga      660

cggcacggca tctctgtcgc tgcctctgga cccctctcga gagttccgct ccaccgttgg      720

acttgctccg ctgtcggcat ccagaaattg cgtggcggag cggcagacgt gagccggcac      780

ggcaggcggc ctcctcctcc tctcacggca cggcagctac gggggattcc tttcccaccg      840

ctccttcgct ttcccttcct cgcccgccgt aataaataga caccccctcc acaccctctt      900

tccccaacct cgtgttgttc ggagcgcaca cacacacaac cagatctccc ccaaatccac      960

ccgtcggcac ctccgcttca aggtacgccg ctcgtcctcc cccccccccc tctctacctt     1020

ctctagatcg gcgttccggt ccatgcatgg ttagggcccg gtagttctac ttctgttcat     1080

gtttgtgtta gatccgtgtt tgtgttagat ccgtgctgct agcgttcgta cacggatgcg     1140

acctgtacgt cagacacgtt ctgattgcta acttgccagt gtttctcttt ggggaatcct     1200

gggatggctc tagccgttcc gcagacggga tcgatttcat gatttttttt gtttcgttgc     1260

atagggtttg gtttgccctt ttcctttatt tcaatatatg ccgtgcactt gtttgtcggg     1320

tcatcttttc atgctttttt ttgtcttggt tgtgatgatg tggtctggtt gggcggtcgt     1380

tctagatcgg agtagaattc tgtttcaaac tacctggtgg atttattaat tttggatctg     1440

tatgtgtgtg ccatacatat tcatagttac gaattgaaga tgatggatgg aaatatcgat     1500

ctaggatagg tatacatgtt gatgcgggtt ttactgatgc atatacagag atgctttttg     1560

ttcgcttggt tgtgatgatg tggtgtggtt gggcggtcgt tcattcgttc tagatcggag     1620

tagaatactg tttcaaacta cctggtgtat ttattaattt tggaactgta tgtgtgtgtc     1680

atacatcttc atagttacga gtttaagatg gatggaaata tcgatctagg ataggtatac     1740

atgttgatgt gggttttact gatgcatata catgatggca tatgcagcat ctattcatat     1800

gctctaacct tgagtaccta tctattataa taaacaagta tgttttataa ttattttgat     1860

cttgatatac ttggatgatg gcatatgcag cagctatatg tggatttttt tagccctgcc     1920

ttcatacgct atttatttgc ttggtactgt ttcttttgtc gatgctcacc ctgttgtttg     1980

gtgttacttc tgcaggtcga ctctagagga tccccatggc cccgaagaag aagaggaagg     2040

tgcacatgga taagaagtac agcatcggcc tcgacatcgg gaccaacagc gtcggctggg     2100

ccgtcatcac cgacgaatat aaggtgccca gcaagaagtt caaggtgctc gggaatacag     2160

accgccacag catcaagaag aacctgatcg gcgccctcct gttcgactcg ggcgagaccg     2220

ctgaggccac cagactaaag aggaccgctc gccgccgcta cacccgccgc aagaaccgca     2280

tatgctacct ccaggagatc ttcagcaacg agatggccaa ggtggacgac agcttcttcc     2340

accgccttga ggagtcgttc ctcgtggagg aggacaagaa gcatgagagg cacccgatct     2400

tcgggaacat cgtggacgag gtaagtttct gcttctacct ttgatatata tataataatt     2460

atcattaatt agtagtaata taatatttca aatatttttt tcaaaataaa agaatgtagt     2520

atatagcaat tgcttttctg tagtttataa gtgtgtatat tttaatttat aacttttcta     2580

atatatgacc aaaacatggt gatgtgcagg tggcgtacca cgagaagtac ccgacgatct     2640

accacctccg caagaagctg gtcgactcca cagacaaggc cgacctcaga ctgatctacc     2700

tggccctcgc gcacatgatc aagttccgcg ggcacttcct catcgagggc gacctgaacc     2760

cggacaactc cgacgtcgac aagctcttca tccagctggt ccagacctac aatcaactgt     2820

tcgaggagaa cccgatcaac gcgtccggcg tggacgcgaa ggccatcctc agcgcgaggc     2880

tcagcaaatc aagacggctg gagaacctga tcgcccagct cccaggcgag aagaaaaacg     2940

gcttgttcgg caacctgatc gcgctctcgc tcggcctcac gcccaacttc aaatcaaact     3000

tcgacctggc cgaggacgcg aaactgcagc tgtccaagga cacttacgac gacgacctcg     3060

acaacctgct ggcgcaaatc ggtgaccagt acgcagacct cttcctggcc gccaagaacc     3120

tctcggacgc catcctgctg tccgatatcc tgagagtgaa tacggagatc accaaggcgc     3180

cgctcagcgc ctccatgatt aaaaggtacg acgagcacca ccaggacctg acgctgctca     3240

aggccctggt gcgccagcag ctccccgaga agtacaagga gatcttcttc gaccaatcaa     3300

aaaacggcta cgccggctac atcgacgggg gcgcctccca ggaggagttc tacaagttca     3360

tcaaaccaat tctcgagaag atggacggca cggaggagct tctcgtgaag ctcaaccggg     3420

aggacctcct gaggaagcag aggacgttcg acaacggctc gataccgcat cagatccacc     3480

tgggcgagct ccacgccatc ctgcgccggc aggaggattt ctatccgttc ctcaaggaca     3540

acagggagaa gatcgagaaa attctgacgt tccgcatccc gtactacgtg ggccctctcg     3600

cgcgcgggaa cagccggttc gcctggatga ctcggaagtc ggaggagacg atcacgccgt     3660

ggaacttcga ggaggtggtg gacaagggcg cctccgccca gtcgttcatc gagcgcatga     3720

cgaacttcga taaaaatctg cccaatgaaa aagtgctccc gaagcacagc ctcctctacg     3780

agtacttcac ggtgtacaac gagctcacga aggtgaagta cgtgaccgag ggtatgcgga     3840

agccggcgtt cctgagcggc gagcagaaga aggccatcgt ggacctcctc ttcaagacga     3900

accggaaagt caccgtgaag caattaaagg aggactactt caagaaaata gagtgcttcg     3960

acagcgtcga gatctcgggc gtcgaggaca ggttcaacgc gtcgctgggc acataccacg     4020

acctcctcaa gatcattaaa gacaaggact tcctggacaa cgaggagaac gaggacatcc     4080

tcgaggacat cgtgctgacc ctcaccctgt ttgaggaccg ggagatgatc gaggagcgcc     4140

tcaagacgta cgctcacctt ttcgacgaca aggtgatgaa acagctgaag cggcgccgct     4200

acaccggatg gggccggctc tcccgcaagc tcattaatgg gatcagggac aagcagtccg     4260

gcaagaccat actcgatttc ctgaagagcg acggcttcgc caaccggaac ttcatgcagc     4320

tcatccacga cgactccctc actttcaagg aggacatcca gaaggcccag gtcagcggac     4380

agggcgactc gctccacgaa cacatcgcca acctggccgg gtcgcctgcg attaaaaagg     4440

gaatccttca gaccgtcaag gtcgtggacg agctggtgaa ggtgatgggc aggcacaagc     4500

ccgaaaatat cgtcattgag atggcccggg agaaccagac cacgcagaaa ggccagaaga     4560

acagccggga gcgcatgaaa cggatcgagg agggtatcaa ggagctgggc tcgcagatcc     4620

tcaaggagca ccctgtggaa aatacccagc tgcagaatga aaagctctac ctctactacc     4680

tccagaacgg ccgcgacatg tacgtggacc aggagctgga cattaatcgc ctctcggact     4740

acgacgtcga ccacatcgtc ccgcagtcct tcctgaagga cgacagcatc gacaacaagg     4800

tcttgacccg ctccgataaa aatcgcggga agtccgacaa cgtgccgtcg gaggaggtgg     4860

tcaagaagat gaaaaactac tggcgccagc tgctcaacgc caagctaatc acgcagcgca     4920

agttcgacaa cctcaccaag gccgaacgcg gcggtctctc cgagcttgat aaggctgggt     4980

tcatcaagag acagctggtg gagacccggc agatcaccaa gcatgtcgcc cagatcctgg     5040

actcgcgcat gaatactaag tacgatgaaa acgacaagct catccgcgag gtgaaggtga     5100

tcaccctgaa gagcaagctg gtctcggact tccggaagga cttccagttc tacaaggtcc     5160

gggagatcaa caactaccac cacgcgcacg acgcctacct gaacgcggtg gtgggcacag     5220

cccttataaa gaagtaccct aagctcgagt ccgagttcgt gtacggcgac tacaaggtgt     5280

acgacgtccg caagatgatc gcgaagagcg agcaggagat cgggaaggcc accgcaaaat     5340

acttcttcta ctccaacatc atgaacttct tcaagaccga gatcaccctg gccaacgggg     5400

agatccgcaa gcgcccgctg attgagacga acggagagac aggcgagata gtctgggaca     5460

agggcaggga cttcgccacc gtgcgcaagg ttctgtccat gccgcaggtg aacatcgtga     5520

agaagactga ggtgcagaca ggcggcttct cgaaggagtc catcctgccc aagcggaaca     5580

gcgacaagct catcgcgcgg aagaaggact gggaccctaa aaaatatggc gggttcgact     5640

cgcccaccgt ggcttactcg gtcctcgtgg tggccaaggt cgagaagggc aaaagcaaga     5700

agctgaagag cgtcaaggag ctcctcggca tcaccatcat ggagcggtcc agcttcgaga     5760

agaacccgat cgacttcctc gaggcgaagg gatataagga ggtgaagaag gacctcatca     5820

ttaaactgcc gaagtactcg ctattcgaac tggagaatgg tcgcaagagg atgctcgcga     5880

gcgctggcga gctgcagaaa gggaacgagc tggctctccc gagcaagtac gtcaacttcc     5940

tctacctggc ctcccactat gaaaagctca agggctcgcc ggaggacaac gagcagaagc     6000

agctgttcgt cgagcagcac aagcattacc tcgacgagat catcgagcag atctcggagt     6060

tcagcaagcg cgtgatcctg gccgacgcca acctcgacaa ggtgctgtcc gcatataaca     6120

agcaccgcga caaaccaata cgggagcagg ccgaaaatat catccacctg ttcaccctca     6180

cgaacctggg cgcccccgcc gcgttcaagt acttcgacac aaccatcgac cgcaagcggt     6240

acacgagcac gaaggaggtg ctggacgcca cgttgattca ccagtccatc acgggcctgt     6300

atgaaacaag gatcgatctc agccagctcg gcggcgacta ggtaccacat ggttaaccta     6360

gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa ggatgcacac     6420

atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact     6480

agttatctga ataaaagaga aagagatcat ccatatttct tatcctaaat gaatgtcacg     6540

tgtctttata attctttgat gaaccagatg catttcatta accaaatcca tatacatata     6600

aatattaatc atatataatt aatatcaatt gggttagcaa aacaaatcta gtctaggtgt     6660

gttttgcgaa ttgcggc                                                    6677


<210>  194
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA version of guide RNA (EPSPS sgRNA)

<400>  194
gcagtaacag ctgctgtcaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt                            100


<210>  195
<211>  3708
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EPSPS polynucleotide template

<400>  195
ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa gtcgctttcc       60

aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc ttgctgcgct      120

gccctgtctc actgctacct aaatgttttg cctgtcgaat accatggatt ctcggtgtaa      180

tccatctcac gatcagatgc accgcatgtc gcatgcctag ctctctctaa tttgtctagt      240

agtttgtata cggattaaga ttgataaatc ggtaccgcaa aagctaggtg taaataaaca      300

ctacaaaatt ggatgttccc ctatcggcct gtactcggct actcgttctt gtgatggcat      360

gttatttctt cttggtgttt ggtgaactcc cttatgaaat ttgggcgcaa agaaatcgcc      420

ctcaagggtt gatcttatgc catcgtcatg ataaacagtg aagcacggat gatcctttac      480

gttgttttta acaaactttg tcagaaaact agcaatgtta acttcttaat gatgatttca      540

caacaaaaaa ggtaaccttg ctactaacat aacaaaagac ttgttgctta ttaattatat      600

gtttttttaa tctttgatca ggggacaaca gtggttgata acctgttgaa cagtgaggat      660

gtccactaca tgctcggggc cttgaggact cttggtctct ctgtcgaagc ggacaaagct      720

gccaaaagag ctgtagttgt tggctgtggt ggaaagttcc cagttgagga tgctaaagag      780

gaagtgcagc tcttcttggg gaatgctgga atcgcaatgc ggtcattgac agcagctgtt      840

actgctgctg gtggaaatgc aacgtatgtt tcctctctct ctctacaata cttgttggag      900

ttagtatgaa acccatgtgt atgtctagtg gcttatggtg tattggtttt tgaacttcag      960

ttacgtgctt gatggagtac caagaatgag ggagagaccc attggcgact tggttgtcgg     1020

attgaagcag cttggtgcag atgttgattg tttccttggc actgactgcc cacctgttcg     1080

tgtcaatgga atcggagggc tacctggtgg caaggttagt tactaagggc cacatgttac     1140

attcttctgt aaatggtaca actattgtcg agcttttgca tttgtaagga aaacattgat     1200

tgatctgaat ttgatgctac accacaaaat atctacaaat ggtcatccct aactagcaaa     1260

ccatgtctcc attaagctca atgaagtaat acttggcatg tgtttatcaa cttaatttcc     1320

atcttctggg gtattgcctg ttttctagtc taatagcatt tgtttttaga attagctctt     1380

acaactgtta tgttctacag gtcaagctgt ctggctccat cagcagtcag tacttgagtg     1440

ccttgctgat ggctgctcct ttggctcttg gggatgtgga gattgaaatc attgataaat     1500

taatctccat tccctacgtc gaaatgacat tgagattgat ggagcgtttt ggtgtgaaag     1560

cagagcattc tgatagctgg gacagattct acattaaggg aggtcaaaaa tacaagtaag     1620

ctctgtaatg tatttcacta ctttgatgcc aatgtttcag ttttcagttt tccaaacagt     1680

cgcatcaata tttgaataga tgcactgtag aaaaaaatca ttgcagggaa aaactagtac     1740

tgagtatttt gactgtaaat tatttaacca gtcggaatat agtcagtcta ttggagtcaa     1800

gagcgtgaac cgaaatagcc agttaattat cccattatac agaggacaac catgtatact     1860

attgaaactt ggtttaagag aatctaggta gctggactcg tagctgcttg gcatggatac     1920

cttcttatct ttaggaaaag acacttgatt ttttttctgt ggccctctat gatgtgtgaa     1980

cctgcttctc tattgcttta gaaggatata tctatgtcgt tatgcaacat gcttccctta     2040

gtcatttgta ctgaaatcag tttcataagt tcgttagtgg ttccctaaac gaaaccttgt     2100

ttttctttgc aatcaacagg tcccctaaaa atgcctatgt tgaaggtgat gcctcaagcg     2160

caagctattt cttggctggt gctgcaatta ctggagggac tgtgactgtg gaaggttgtg     2220

gcaccaccag tttgcaggta aagatttctt ggctggtgct acgataactg cttttgtctt     2280

tttggtttca gcattgttct cagagtcact aaataacatt atcatctgca aacgtcaaat     2340

agacatactt aggtgaatgg atattcatgt aaccgtttcc ttacaaattt gctgaaacct     2400

cagggtgatg tgaagtttgc tgaggtactg gagatgatgg gagcgaaggt tacatggacc     2460

gagactagcg taactgttac tggcccaccg cgggagccat ttgggaggaa acacctcaag     2520

gcgattgatg tcaacatgaa caagatgcct gatgtcgcca tgactcttgc tgtggttgcc     2580

ctctttgccg atggcccgac agccatcaga gacggtaaaa cattctcagc cctacaacca     2640

tgcctcttct acatcactac ttgacaagac taaaaactat tggctcgttg gcagtggctt     2700

cctggagagt aaaggagacc gagaggatgg ttgcgatccg gacggagcta accaaggtaa     2760

ggctacatac ttcacatgtc tcacgtcgtc tttccatagc tcgctgcctc ttagcggctt     2820

gcctgcggtc gctccatcct cggttgctgt ctgtgttttc cacagctggg agcatctgtt     2880

gaggaagggc cggactactg catcatcacg ccgccggaga agctgaacgt gacggcgatc     2940

gacacgtacg acgaccacag gatggccatg gccttctccc ttgccgcctg tgccgaggtc     3000

cccgtgacca tccgggaccc tgggtgcacc cggaagacct tccccgacta cttcgatgtg     3060

ctgagcactt tcgtcaagaa ttaataaagc gtgcgatact accacgcagc ttgattgaag     3120

tgataggctt gtgctgagga aatacatttc ttttgttctg ttttttctct ttcacgggat     3180

taagttttga gtctgtaacg ttagttgttt gtagcaagtt tctatttcgg atcttaagtt     3240

tgtgcactgt aagccaaatt tcatttcaag agtggttcgt tggaataata agaataataa     3300

attacgtttc agtggctgtc aagcctgctg ctacgtttta ggagatggca ttagacattc     3360

atcatcaaca acaataaaac cttttagcct caaacaataa tagtgaagtt attttttagt     3420

cctaaacaag ttgcattagg atatagttaa aacacaaaag aagctaaagt tagggtttag     3480

acatgtggat attgttttcc atgtatagta tgttctttct ttgagtctca tttaactacc     3540

tctacacata ccaactttag ttttttttct acctcttcat gttactatgg tgccttctta     3600

tcccactgag cattggtata tttagaggtt tttgttgaac atgcctaaat catctcaatc     3660

aacgatggac aatcttttct tcgattgagc tgaggtacgt catctaga                  3708


<210>  196
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TIPS nucleotide modifications

<400>  196
atcgcaatgc ggtca                                                        15


<210>  197
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-1 F-E2

<400>  197
ccgaggagat cgtgctgca                                                    19


<210>  198
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-2 F-E2

<400>  198
caatggccgc attgcagttc                                                   20


<210>  199
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-1 F-T

<400>  199
ccgaggagat cgtgctgca                                                    19


<210>  200
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-2 F-T

<400>  200
tgaccgcatt gcgattccag                                                   20


<210>  201
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-1 H-T

<400>  201
tccaagtcgc tttccaacag gatc                                              24


<210>  202
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-2 H-T

<400>  202
tgaccgcatt gcgattccag                                                   20


<210>  203
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-1 F-E3

<400>  203
ccgaggagat cgtgctgca                                                    19


<210>  204
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Seqeunce-2 F-E3

<400>  204
accaagctgc ttcaatccga caac                                              24


<210>  205
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA fragment with intact Cas target sequence

<400>  205
ggggaatgct ggaactgcaa tgcggccatt gacagcagct gttactgctg ctggtggaaa       60

tgc                                                                     63


<210>  206
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA fragment with mutated Cas target sequence

<400>  206
ggggaatgct ggaactgcaa tgcggccatt ggcagctgtt actgctgctg gtggaaatgc       60


<210>  207
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA fragment with mutated Cas target sequence

<400>  207
ggggaatgct ggaactgcac agcagctgtt actgctgctg gtggaaatgc                  50


<210>  208
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA fragment with mutated Cas target sequence

<400>  208
ggggaatgct gttactgctg ctggtggaaa tgc                                    33


<210>  209
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TIPS edited EPSPS nucleotide sequence fragment

<400>  209
aatgctggaa tcgcaatgcg gtcattgaca gcagctgtta ctgctgctgg t                51


<210>  210
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Wild-type epsps nucleotide sequence  fragment

<400>  210
aatgctggaa ctgcaatgcg gccattgaca gcagctgtta ctgctgctgg t                51


<210>  211
<211>  5124
<212>  DNA
<213>  Zea mays

<400>  211
atggcggcca tggcgaccaa ggccgccgcg ggcaccgtgt cgctggacct cgccgcgccg       60

ccggcggcgg cagcggcggc ggcggtgcag gcgggtgccg aggagatcgt gctgcagccc      120

atcaaggaga tctccggcac cgtcaagctg ccggggtcca agtcgctttc caacaggatc      180

ctcctgctcg ccgccctgtc cgaggtgagc gattttggtg cttgctgcgc tgccctgtct      240

cactgctacc taaatgtttt gcctgtcgaa taccatggat tctcggtgta atccatctca      300

cgatcagatg caccgcatgt cgcatgccta gctctctcta atttgtctag tagtttgtat      360

acggattaag attgataaat cggtaccgca aaagctaggt gtaaataaac actacaaaat      420

tggatgttcc cctatcggcc tgtactcggc tactcgttct tgtgatggca tgttatttct      480

tcttggtgtt tggtgaactc ccttatgaaa tttgggcgca aagaaatcgc cctcaagggt      540

tgatcttatg ccatcgtcat gataaacagt gaagcacgga tgatccttta cgttgttttt      600

aacaaacttt gtcagaaaac tagcaatgtt aacttcttaa tgatgatttc acaacaaaaa      660

aggtaacctt gctactaaca taacaaaaga cttgttgctt attaattata tgttttttta      720

atctttgatc aggggacaac agtggttgat aacctgttga acagtgagga tgtccactac      780

atgctcgggg ccttgaggac tcttggtctc tctgtcgaag cggacaaagc tgccaaaaga      840

gctgtagttg ttggctgtgg tggaaagttc ccagttgagg atgctaaaga ggaagtgcag      900

ctcttcttgg ggaatgctgg aactgcaatg cggccattga cagcagctgt tactgctgct      960

ggtggaaatg caacgtatgt ttcctctctc tctctacaat acttgttgga gttagtatga     1020

aacccatgtg tatgtctagt ggcttatggt gtattggttt ttgaacttca gttacgtgct     1080

tgatggagta ccaagaatga gggagagacc cattggcgac ttggttgtcg gattgaagca     1140

gcttggtgca gatgttgatt gtttccttgg cactgactgc ccacctgttc gtgtcaatgg     1200

aatcggaggg ctacctggtg gcaaggttag ttactaaggg ccacatgtta cattcttctg     1260

taaatggtac aactattgtc gagcttttgc atttgtaagg aaaacattga ttgatctgaa     1320

tttgatgcta caccacaaaa tatctacaaa tggtcatccc taactagcaa accatgtctc     1380

cattaagctc aatgaagtaa tacttggcat gtgtttatca acttaatttc catcttctgg     1440

ggtattgcct gttttctagt ctaatagcat ttgtttttag aattagctct tacaactgtt     1500

atgttctaca ggtcaagctg tctggctcca tcagcagtca gtacttgagt gccttgctga     1560

tggctgctcc tttggctctt ggggatgtgg agattgaaat cattgataaa ttaatctcca     1620

ttccctacgt cgaaatgaca ttgagattga tggagcgttt tggtgtgaaa gcagagcatt     1680

ctgatagctg ggacagattc tacattaagg gaggtcaaaa atacaagtaa gctctgtaat     1740

gtatttcact actttgatgc caatgtttca gttttcagtt ttccaaacag tcgcatcaat     1800

atttgaatag atgcactgta gaaaaaaatc attgcaggga aaaactagta ctgagtattt     1860

tgactgtaaa ttatttaacc agtcggaata tagtcagtct attggagtca agagcgtgaa     1920

ccgaaatagc cagttaatta tcccattata cagaggacaa ccatgtatac tattgaaact     1980

tggtttaaga gaatctaggt agctggactc gtagctgctt ggcatggata ccttcttatc     2040

tttaggaaaa gacacttgat tttttttctg tggccctcta tgatgtgtga acctgcttct     2100

ctattgcttt agaaggatat atctatgtcg ttatgcaaca tgcttccctt agtcatttgt     2160

actgaaatca gtttcataag ttcgttagtg gttccctaaa cgaaaccttg tttttctttg     2220

caatcaacag gtcccctaaa aatgcctatg ttgaaggtga tgcctcaagc gcaagctatt     2280

tcttggctgg tgctgcaatt actggaggga ctgtgactgt ggaaggttgt ggcaccacca     2340

gtttgcaggt aaagatttct tggctggtgc tacgataact gcttttgtct ttttggtttc     2400

agcattgttc tcagagtcac taaataacat tatcatctgc aaacgtcaaa tagacatact     2460

taggtgaatg gatattcatg taaccgtttc cttacaaatt tgctgaaacc tcagggtgat     2520

gtgaagtttg ctgaggtact ggagatgatg ggagcgaagg ttacatggac cgagactagc     2580

gtaactgtta ctggcccacc gcgggagcca tttgggagga aacacctcaa ggcgattgat     2640

gtcaacatga acaagatgcc tgatgtcgcc atgactcttg ctgtggttgc cctctttgcc     2700

gatggcccga cagccatcag agacggtaaa acattctcag ccctacaacc atgcctcttc     2760

tacatcacta cttgacaaga ctaaaaacta ttggctcgtt ggcagtggct tcctggagag     2820

taaaggagac cgagaggatg gttgcgatcc ggacggagct aaccaaggta aggctacata     2880

cttcacatgt ctcacgtcgt ctttccatag ctcgctgcct cttagcggct tgcctgcggt     2940

cgctccatcc tcggttgctg tctgtgtttt ccacagctgg gagcatctgt tgaggaaggg     3000

ccggactact gcatcatcac gccgccggag aagctgaacg tgacggcgat cgacacgtac     3060

gacgaccaca ggatggccat ggccttctcc cttgccgcct gtgccgaggt ccccgtgacc     3120

atccgggacc ctgggtgcac ccggaagacc ttccccgact acttcgatgt gctgagcact     3180

ttcgtcaaga attaataaag cgtgcgatac taccacgcag cttgattgaa gtgataggct     3240

tgtgctgagg aaatacattt cttttgttct gttttttctc tttcacggga ttaagttttg     3300

agtctgtaac gttagttgtt tgtagcaagt ttctatttcg gatcttaagt ttgtgcactg     3360

taagccaaat ttcatttcaa gagtggttcg ttggaataat aagaataata aattacgttt     3420

cagtggctgt caagcctgct gctacgtttt aggagatggc attagacatt catcatcaac     3480

aacaataaaa ccttttagcc tcaaacaata atagtgaagt tattttttag tcctaaacaa     3540

gttgcattag gatatagtta aaacacaaaa gaagctaaag ttagggttta gacatgtgga     3600

tattgttttc catgtatagt atgttctttc tttgagtctc atttaactac ctctacacat     3660

accaacttta gttttttttc tacctcttca tgttactatg gtgccttctt atcccactga     3720

gcattggtat atttagaggt ttttgttgaa catgcctaaa tcatctcaat caacgatgga     3780

caatcttttc ttcgattgag ctgaggtacg tcatctagag gataggacct tgagaatatg     3840

tgtccgtcaa tagctaaccc tctactaatt ttttcaatca agcaacctat tggcttgact     3900

ttaattcgta ccggcttcta ctacttctac agtattttgt ctctataaat tgcagctaca     3960

acagtcagaa cggctggctt taaaatcaaa tggcctaagg atcattgaaa ggcatcttag     4020

caatgtctaa aattattacc ttctctagac gttgatatct ttgctccgga ttcgatccct     4080

tgttgtatga ccacaaatcc aacaccaaat acgcatttct gcaacacacc caaacacccc     4140

ttccaaataa gtggaatggt tgagaaattt gctattttga ttaaatattg gtgaaggggc     4200

aaggctgagg aaacgagacg aaggttcctt gacagctgaa aaatggaaca ctctagaggc     4260

ggagggagcg aggcgagctg tgtgaattgc cacccattga ttaagaatcc aacaacttga     4320

ctagcaaatg ccgacatggg tagcctacaa aggcgagttt tggagctggt ttcgtaataa     4380

ggaaatttct caaccaacta ctttccttag aaaagagttg cttgaccgga tcaacatctc     4440

cccctaaacc ccttggaggg ggagggggct aagattttaa tctacaagtt agatctaact     4500

gtccacctca atccccctca aggaggtttt tgtattattt gttagtgtag aatgataaag     4560

tggatgtatt gataggagat ggggtacaca tatttatagg gactcaaccc taaccctaat     4620

gggtcggcag cccaacagtg gtgtccggcc cacacacaca ctcacacaca cagtctaaca     4680

tcccccgcag tcgcaacggg gacaccacac acgatgagac tggagtagag gccgaaggta     4740

ggagccgacg ggttgaaatc ccccctagtc gcagcgtcgt gatagtacga atgttgcggc     4800

tggagtagag accggtgtgt gctccaagaa gacgatagcc cctagatgcc gaggtagccg     4860

aagtcgaggt ggtcgcggtc ggaagacgcg cagcaaaagc ctgatcttcg ggatggtcga     4920

cgttcgagcg tcaacgatcg gtagggcgac acaataaaag ggcaccagca ggtcgacctt     4980

cctgcttctt cgatcgtcca gacgtcaagg agcctcgcta gggaggccga cggcagcgca     5040

cgcggctacg ccggtcatgg tgtcctcacc cgcggcagaa aagaagggga atgtcggatc     5100

cgaccgagaa ggccacggca gcga                                            5124


<210>  212
<211>  3387
<212>  DNA
<213>  S. thermophilus

<400>  212
atgagtgact tagttttagg acttgatatc ggtataggtt ctgttggtgt aggtatcctt       60

aacaaagtga caggagaaat tatccataaa aactcacgca tcttcccagc agctcaagca      120

gaaaataacc tagtacgtag aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa      180

catcgtatag ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg      240

aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac cgatgaattg      300

tctaatgaag aactgtttat cgctcttaaa aatatggtga aacaccgtgg gattagttac      360

ctcgatgatg ctagtgatga cggaaattca tcagtaggag actatgcaca aattgttaag      420

gaaaatagta aacaattaga aactaagaca ccgggacaga tacagttgga acgctaccaa      480

acatatggtc aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg      540

attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact gcaaactcaa      600

caagaattta atccacagat tacagatgaa tttattaatc gttatctcga aattttaact      660

ggaaaacgga aatattatca tggacccgga aatgaaaagt cacggactga ttatggtcgt      720

tacagaacga gtggagaaac tttagacaat atttttggaa ttctaattgg gaaatgtaca      780

ttttatccag aagagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg      840

ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag caaagaacag      900

aagaatcaaa tcattaatta tgtcaaaaat gaaaaggcaa tggggccagc gaaacttttt      960

aaatatatcg ctaagttact ttcttgtgat gttgcagata tcaagggata ccgtatcgac     1020

aaatcaggta aggctgagat tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa     1080

accttagata ttgaacaaat ggatagagaa acgcttgata aattagccta tgtcttaaca     1140

ttaaacactg agagggaagg tattcaagaa gccttagaac atgaatttgc tgatggtagc     1200

tttagccaga agcaagttga cgaattggtt caattccgca aagcaaatag ttccattttt     1260

ggaaaaggat ggcataattt ttctgtcaaa ctgatgatgg agttaattcc agaattgtat     1320

gagacgtcag aagagcaaat gactatcctg acacgacttg gaaaacaaaa acgacttcgt     1380

cttcaaataa aacaaaatat ttcaaataaa acaaaatata tagatgagaa actattaact     1440

gaagaaatct ataatcctgt tgttgctaag tctgttcgcc aggctataaa aatcgtaaat     1500

gcggcgatta aagaatacgg agactttgac aatattgtca tcgaaatggc tcgtgaaaca     1560

aatgaagatg atgaaaagaa agctattcaa aagattcaaa aagccaacaa agatgaaaaa     1620

gatgcagcaa tgcttaaggc tgctaaccaa tataatggaa aggctgaatt accacatagt     1680

gttttccacg gtcataagca attagcgact aaaatccgcc tttggcatca gcaaggagaa     1740

cgttgccttt atactggtaa gacaatctca atccatgatt tgataaataa tcctaatcag     1800

tttgaagtag atcatatttt acctctttct atcacattcg atgatagcct tgcaaataag     1860

gttttggttt atgcaactgc taaccaagaa aaaggacaac gaacacctta tcaggcttta     1920

gatagtatgg atgatgcgtg gtctttccgt gaattaaaag cttttgtacg tgagtcaaaa     1980

acactttcaa acaagaaaaa agaatacctc cttacagaag aagatatttc aaagtttgat     2040

gttcgaaaga aatttattga acgaaatctt gtagatacaa gatacgcttc aagagttgtc     2100

ctcaatgccc ttcaagaaca ctttagagct cacaagattg atacaaaagt ttccgtggtt     2160

cgtggccaat ttacatctca attgagacgc cattggggaa ttgagaagac tcgtgatact     2220

tatcatcacc atgctgtcga tgcattgatt attgccgcct caagtcagtt gaatttgtgg     2280

aaaaaacaaa agaataccct tgtaagttat tcagaagaac aactccttga tattgaaaca     2340

ggtgaactta ttagtgatga tgagtacaag gaatctgtgt tcaaagcccc ttatcaacat     2400

tttgttgata cattgaagag taaagaattt gaagacagta tcttattctc atatcaagtg     2460

gattctaagt ttaatcgtaa aatatcagat gccactattt atgcgacaag acaggctaaa     2520

gtgggaaaag ataagaagga tgaaacttat gtcttaggga aaatcaaaga tatctatact     2580

caggatggtt atgatgcctt tatgaagatt tataagaagg ataagtcaaa attcctcatg     2640

tatcgtcacg acccacaaac ctttgagaaa gttatcgagc caattttaga gaactatcct     2700

aataagcaaa tgaatgaaaa aggaaaagag gtaccatgta atcctttcct aaaatataaa     2760

gaagaacatg gctatattcg taaatatagt aaaaaaggca atggtcctga aatcaagagt     2820

cttaaatact atgatagtaa gcttttaggt aatcctattg atattactcc agagaatagt     2880

aaaaataaag ttgtcttaca gtcattaaaa ccttggagaa cagatgtcta tttcaataag     2940

gctactggaa aatacgaaat ccttggatta aaatatgctg atctacaatt tgagaaaggg     3000

acaggaacat ataagatttc ccaggaaaaa tacaatgaca ttaagaaaaa agagggtgta     3060

gattctgatt cagaattcaa gtttacactt tataaaaatg atttgttact cgttaaagat     3120

acagaaacaa aagaacaaca gcttttccgt tttctttctc gaactttacc taaacaaaag     3180

cattatgttg aattaaaacc ttatgataaa cagaaatttg aaggaggtga ggcgttaatt     3240

aaagtgttgg gtaacgttgc taatggtggt caatgcataa aaggactagc aaaatcaaat     3300

atttctattt ataaagtaag aacagatgtc ctaggaaatc agcatatcat caaaaatgag     3360

ggtgataagc ctaagctaga tttttaa                                         3387


<210>  213
<211>  3369
<212>  DNA
<213>  S. thermophilus

<400>  213
atgagtgact tagttttagg acttgatatc ggtataggtt ctgttggtgt aggtatcctt       60

aacaaagtga caggagaaat tatccataaa aactcacgca tcttcccagc agctcaagca      120

gaaaataacc tagtacgtag aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa      180

catcgtatag ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg      240

aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac cgatgaattg      300

tctaatgaag aactgtttat cgctcttaaa aatatggtga aacaccgtgg gattagttac      360

ctcgatgatg ctagtgatga cggaaattca tcagtaggag actatgcaca aattgttaag      420

gaaaatagta aacaattaga aactaagaca ccgggacaga tacagttgga acgctaccaa      480

acatatggtc aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg      540

attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact gcaaactcaa      600

caagaattta attcacagat tacagatgaa tttattaatc gttatctcga aattttaact      660

ggaaaacgga aatattatca tggacccgga aatgaaaagt cacggactga ttatggtcgt      720

tacagaacga atggagaaac tttagacaat atttttggaa ttctaattgg gaaatgtaca      780

ttttatccag acgagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg      840

ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag caaagaacag      900

aagaatcaaa tcattaatta tgtcaaaaat gaaaaggtaa tggggccagc gaaacttttt      960

aaatatatcg ctaaattact ttcttgtgat gttgcagata tcaagggaca ccgtatcgac     1020

aaatcaggta aggctgagat tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa     1080

accttagata ttgagcaaat ggatagagaa acgcttgata aattagccta tgtcttaaca     1140

ttaaacactg agagggaagg tattcaagaa gctttagaac atgaatttgc tgatggtagc     1200

tttagccaga agcaagttga cgaattggtt caattccgca aagcaaatag ttccattttt     1260

ggaaaaggat ggcataattt ttctgtcaaa ctgatgatgg agttaattcc agaattgtat     1320

gagacgtcag aagagcaaat gactatcctg acacgacttg gaaaacaaaa aacaacttcg     1380

tcttcaaata aaacaaaata tatagatgag aaactattaa ctgaagaaat ctataatcct     1440

gttgttgcta agtctgttcg ccaggctata aaaatcgtaa atgcggcgat taaagaatac     1500

ggagactttg acaatattgt catcgaaatg gctcgtgaaa caaatgaaga tgatgaaaag     1560

aaagctattc aaaagattca aaaagccaac aaagatgaaa aagatgcagc aatgcttaag     1620

gctgctaacc aatataatgg aaaggctgaa ttaccacata gtgttttcca cggtcataag     1680

caattagcga ctaaaatccg cctttggcat cagcaaggag aacgttgcct ttatactggt     1740

aagacaatct caatccatga tttgataaat aatcctaatc agtttgaagt agatcatatt     1800

ttacctcttt ctatcacatt cgatgatagc cttgcaaata aggttttggt ttatgcaact     1860

gctaaccaag aaaaaggaca acgaacacct tatcaggctt tagatagtat ggatgatgcg     1920

tggtctttcc gtgaattaaa agcttttgta cgtgagtcaa aaacactttc aaacaagaaa     1980

aaagaatacc tccttacaga agaagatatt tcaaagtttg atgttcgaaa gaaatttatt     2040

gaacgaaatc ttgtagatac aagatacgct tcaagagttg tcctcaatgc ccttcaagaa     2100

cactttagag ctcacaagat tgatacaaaa gtttccgtgg ttcgtggcca atttacatct     2160

caattgagac gccattgggg aattgagaag actcgtgata cttatcatca ccatgctgtc     2220

gatgcattga ttattgccgc ctcaagtcag ttgaatttgt ggaaaaaaca aaagaatacc     2280

cttgtaagtt attcagaaga acaactcctt gatattgaaa caggtgaact tattagtgat     2340

gatgagtaca aggaatctgt gttcaaagcc ccttatcaac attttgttga tacattgaag     2400

agtaaagaat ttgaagacag tatcttattc tcatatcaag tggattctaa gtttaatcgt     2460

aaaatatcag atgccactat ttatgcgaca agacaggcta aagtgggaaa agataagaag     2520

gatgaaactt atgtcttagg gaaaatcaaa gatatctata ctcaggatgg ttatgatgcc     2580

tttatgaaga tttataagaa ggataagtca aaattcctca tgtatcgtca cgacccacaa     2640

acctttgaga aagttatcga gccaatttta gagaactatc ctaataagga aatgaatgaa     2700

aaagggaaag aagtaccatg taatcctttc ctaaaatata aagaagaaca tggctatatt     2760

cgtaaatata gtaaaaaagg caatggtcct gaaatcaaga gtcttaaata ctatgatagt     2820

aagcttttag gtaatcctat tgatattact ccagagaata gtaaaaataa agttgtctta     2880

cagtcattaa aaccttggag aacagatgtc tatttcaata aaaatactgg taaatatgaa     2940

attttaggac tgaaatatgc tgatttacaa tttgaaaaga agacaggaac atataagatt     3000

tcccaggaaa aatacaatgg cattatgaaa gaagagggtg tagattctga ttcagaattc     3060

aagtttacac tttataaaaa tgatttgtta ctcgttaaag atacagaaac aaaagaacaa     3120

cagcttttcc gttttctttc tcgaactatg cctaatgtga aatattatgt agagttaaag     3180

ccttattcaa aagataaatt tgagaagaat gagtcactta ttgaaatttt aggttctgca     3240

gataagtcag gacgatgtat aaaagggcta ggaaaatcaa atatttctat ttataaggta     3300

agaacagatg tcctaggaaa tcagcatatc atcaaaaatg agggtgataa gcctaagcta     3360

gatttttaa                                                             3369


<210>  214
<211>  4113
<212>  DNA
<213>  S. agalactiae

<400>  214
atgaataagc catattcaat aggccttgac atcggtacta attccgtcgg atggagcatt       60

attacagatg attataaagt acctgctaag aagatgagag ttttagggaa cactgataaa      120

gaatatatta agaagaatct cataggtgct ctgctttttg atggcgggaa tactgctgca      180

gatagacgct tgaagcgaac tgctcgtcgt cgttatacac gtcgtagaaa tcgtattcta      240

tatttacaag aaatttttgc agaggaaatg agtaaagttg atgatagttt ctttcatcga      300

ttagaggatt cttttctagt tgaggaagat aagagaggga gcaagtatcc tatctttgca      360

acattgcagg aagagaaaga ttatcatgaa aaattttcga caatctatca tttgagaaaa      420

gaattagctg acaagaaaga aaaagcagac cttcgtctta tttatattgc tctagctcat      480

atcattaaat ttagagggca tttcctaatt gaggatgata gctttgatgt caggaataca      540

gacatttcaa aacaatatca agatttttta gaaatcttta atacaacttt tgaaaataat      600

gatttgttat ctcaaaacgt tgacgtagag gcaatactaa cagataagat tagcaagtct      660

gcgaagaaag atcgtatttt agcgcagtat cctaaccaaa aatctactgg catttttgca      720

gaatttttga aattgattgt cggaaatcaa gctgacttca agaaatattt caatttggag      780

gataaaacgc cgcttcaatt cgctaaggat agctacgatg aagatttaga aaatcttctt      840

ggacagattg gtgatgaatt tgcagactta ttctcagcag cgaaaaagtt atatgatagt      900

gtccttttgt ctggcattct tacagtaatc gacctcagta ccaaggcgcc actttcagct      960

tctatgattc agcgttatga tgaacataga gaggacttga aacagttaaa acaattcgta     1020

aaagcttcat tgccggaaaa atatcaagaa atatttgctg attcatcaaa agatggctac     1080

gctggttata ttgaaggtaa aactaatcaa gaagcttttt ataaatacct gtcaaaattg     1140

ttgaccaagc aagaagatag cgagaatttt cttgaaaaaa tcaagaatga agatttcttg     1200

agaaaacaaa ggacctttga taatggctca attccacacc aagtccattt gacagagctg     1260

aaagctatta tccgccgtca atcagaatac tatcccttct tgaaagagaa tcaagatagg     1320

attgaaaaaa tccttacctt tagaattcct tattatatcg ggccactagc acgtgagaag     1380

agtgattttg catggatgac tcgcaaaaca gatgacagta ttcgaccttg gaattttgaa     1440

gacttggttg ataaagaaaa atctgcggaa gcttttatcc atcgtatgac caacaatgat     1500

ttttatcttc ctgaagaaaa agttttacca aagcatagtc ttatttatga aaaatttacg     1560

gtctataatg agttgactaa ggttagatat aaaaatgagc aaggtgagac ttattttttt     1620

gatagcaata ttaaacaaga aatctttgat ggagtattca aggaacatcg taaggtatcc     1680

aagaagaagt tgctagattt tctggctaaa gaatatgagg agtttaggat agtagatgtt     1740

attggtctag ataaagaaaa taaagctttc aacgcctcat tgggaactta ccacgatctc     1800

gaaaaaatac tagacaaaga ttttctagat aatccagata atgagtctat tctggaagat     1860

atcgtccaaa ctctaacatt atttgaagac agagaaatga ttaagaagcg tcttgaaaac     1920

tataaagatc tttttacaga gtcacaacta aaaaaactct atcgtcgtca ctatactggc     1980

tggggacgat tgtctgctaa gttaatcaat ggtattcgag ataaagagag tcaaaaaaca     2040

atcttggact atcttattga tgatggtaga tctaatcgca actttatgca gttgataaat     2100

gatgatggtc tatctttcaa atcaattatc agtaaggcac aggctggtag tcattcagat     2160

aatctaaaag aagttgtagg tgagcttgca ggtagccctg ctattaaaaa gggaattcta     2220

caaagtttga aaattgttga tgagcttgtt aaagtcatgg gatacgaacc tgaacaaatt     2280

gtggttgaga tggcgcgtga gaatcaaaca acaaatcaag gtcgtcgtaa ctctcgacaa     2340

cgctataaac ttcttgatga tggcgttaag aatctagcta gtgacttgaa tggcaatatt     2400

ttgaaagaat atcctacgga taatcaagcg ttgcaaaatg aaagactttt cctttactac     2460

ttacaaaacg gaagagatat gtatacaggg gaagctctag atattgacaa tttaagtcaa     2520

tatgatattg accacattat tcctcaagct ttcataaaag atgattctat tgataatcgt     2580

gttttggtat catctgctaa aaatcgtgga aagtcagatg atgttcctag ccttgaaatt     2640

gtaaaagatt gtaaagtttt ctggaaaaaa ttacttgatg ctaagttaat gagtcagcgt     2700

aagtatgata atttgactaa ggcagagcgc ggaggcctaa cttccgatga taaggcaaga     2760

tttatccaac gtcagttggt tgagacacga caaattacca agcatgttgc ccgtatcttg     2820

gatgaacgct ttaataatga gcttgatagt aaaggtagaa ggatccgcaa agttaaaatt     2880

gtaaccttga agtcaaattt ggtttcaaat ttccgaaaag aatttggatt ctataaaatt     2940

cgtgaagtta acaattatca ccatgcacat gatgcctatc ttaatgcagt agttgctaaa     3000

gctattctaa ccaaatatcc tcagttagag ccagaatttg tctacggcga ctatccaaaa     3060

tataatagtt acaaaacgcg taaatccgct acagaaaagc tatttttcta ttcaaatatt     3120

atgaacttct ttaaaactaa ggtaacttta gcggatggaa ccgttgttgt aaaagatgat     3180

attgaagtta ataatgatac gggtgaaatt gtttgggata aaaagaaaca ctttgcgaca     3240

gttagaaaag tcttgtcata ccctcagaac aatatcgtga agaagacaga gattcagaca     3300

ggtggtttct ctaaggaatc aatcttggcg catggtaact cagataagtt gattccaaga     3360

aaaacgaagg atatttattt agatcctaag aaatatggag gttttgatag tccgatagta     3420

gcttactctg ttttagttgt agctgatatc aaaaagggta aagcacaaaa actaaaaaca     3480

gttacggaac ttttaggaat taccatcatg gagaggtcca gatttgagaa aaatccatca     3540

gctttccttg aatcaaaagg ctatttaaat attagggctg ataaactaat tattttgccc     3600

aagtatagtc tgttcgaatt agaaaatggg cgtcgtcgat tacttgctag tgctggtgaa     3660

ttacaaaaag gtaatgagct agccttacca acacaattta tgaagttctt ataccttgca     3720

agtcgttata atgagtcaaa aggtaaacca gaggagattg agaagaaaca agaatttgta     3780

aatcaacatg tctcttattt tgatgacatc cttcaattaa ttaatgattt ttcaaaacga     3840

gttattctag cagatgctaa tttagagaaa atcaataagc tttaccaaga taataaggaa     3900

aatatatcag tagatgaact tgctaataat attatcaatc tatttacttt taccagtcta     3960

ggagctccag cagcttttaa attttttgat aaaatagttg atagaaaacg ctatacatca     4020

actaaagaag tacttaattc taccctaatt catcaatcta ttactggact ttatgaaaca     4080

cgtattgatt tgggtaagtt aggagaagat tga                                  4113


<210>  215
<211>  4134
<212>  DNA
<213>  S. agalactiae

<400>  215
atgaataagc catattcaat aggccttgac atcggtacta attccgtcgg atggagcatt       60

attacagatg attataaagt acctgctaag aagatgagag ttttagggaa cactgataaa      120

gaatatatta agaagaatct cataggtgct ctgctttttg atggcgggaa tactgctgca      180

gatagacgct tgaagcgaac tgctcgtcgt cgttatacac gtcgtagaaa tcgtattcta      240

tatttacaag aaatttttgc agaggaaatg agtaaagttg atgatagttt ctttcatcga      300

ttagaggatt cttttctagt tgaggaagat aagagaggta gcaagtatcc tatctttgca      360

acaatgcagg aggagaaata ttatcatgaa aaatttccga caatctatca tttgagaaaa      420

gaattggctg acaagaaaga aaaagcagac cttcgtcttg tttatctggc tctagctcat      480

atcattaaat tcagagggca tttcctaatt gaggatgata gatttgatgt gaggaatacc      540

gatattcaaa aacaatatca agccttttta gaaatttttg atactacctt tgaaaataat      600

catttgttat ctcaaaatgt agatgtagaa gcaattctaa cagataagat tagcaagtct      660

gcgaagaagg atcgcatctt agcgcagtat cctaaccaaa aatctactgg tatttttgca      720

gaatttttga aattgattgt cggaaatcaa gctgacttca agaaacattt caatttggag      780

gataaaacac cgcttcaatt cgctaaggat agctacgatg aagatttaga aaatcttctt      840

ggacagattg gtgatgaatt tgcagactta ttctcagtag cgaaaaagct atatgatagt      900

gttcttttat ctggcattct tacagtaact gatctcagta ccaaggcgcc actttctgcc      960

tctatgattc agcgttatga tgaacatcat gaggacttaa agcatctaaa acaattcgta     1020

aaagcttcat tacctgaaaa ttatcgggaa gtatttgctg attcatcaaa agatggctac     1080

gctggctata ttgaaggcaa aactaatcaa gaagcttttt ataaatatct gttaaaattg     1140

ttgaccaaac aagaaggtag cgagtatttt cttgagaaaa ttaagaatga agattttttg     1200

agaaaacaga gaacctttga taatggctca atcccgcatc aagtccattt gacagaattg     1260

agggctatta ttcgacgtca atcagaatac tatccattct tgaaagagaa tcaagatagg     1320

attgaaaaaa tccttacctt tagaattcct tattatgtcg ggccactagc acgtgagaag     1380

agtgattttg catggatgac tcgcaaaaca gatgacagta ttcgaccttg gaattttgaa     1440

gacttggttg ataaagaaaa atctgcggaa gcttttatcc atcgcatgac caacaatgac     1500

ctctatcttc cagaagaaaa agttttacca aagcatagtc ttatttatga aaaatttact     1560

gtttacaatg aattaacgaa ggttagattt ttggcagaag gctttaaaga ttttcaattt     1620

ttaaatagga agcaaaaaga aactatcttt aacagcttgt ttaaggaaaa acgtaaagta     1680

actgaaaagg atattattag ttttttgaat aaagttgatg gatatgaagg aattgcaatc     1740

aaaggaattg agaaacagtt taacgctagc ctttcaacct atcatgatct taaaaaaata     1800

cttggcaagg atttccttga taatacagat aacgagctta ttttggaaga tatcgtccaa     1860

actctaacct tatttgaaga tagagaaatg attaagaagt gtcttgacat ctataaagat     1920

ttttttacag agtcacagct taaaaagctc tatcgccgtc actatactgg ctggggacga     1980

ttgtctgcta agctaataaa tggcatccga aataaagaga atcaaaaaac aatcttggac     2040

tatcttattg atgatggaag tgcaaaccga aacttcatgc agttgataaa tgatgatgat     2100

ctatcattta aaccaattat tgacaaggca cgaactggta gtcattcgga taatctgaaa     2160

gaagttgtag gtgaacttgc tggtagccct gctattaaaa aagggattct acaaagtttg     2220

aaaatagttg atgagctggt taaagtcatg ggctatgaac ctgaacaaat cgtggttgaa     2280

atggcacgtg agaaccaaac gacagcaaaa ggattaagtc gttcacgaca acgcttgaca     2340

accttgagag aatctcttgc taatttgaag agtaatattt tggaagagaa aaagcctaag     2400

tatgtgaaag atcaagttga aaatcatcat ttatctgatg accgtctttt cctttactac     2460

ttacaaaacg gaagagatat gtatacaaaa aaggctctgg atattgataa tttaagtcaa     2520

tatgatattg accacattat tcctcaagct ttcataaaag atgattctat tgataatcgt     2580

gttttggtat catctgctaa aaatcgtgga aaatcagatg atgttcctag cattgaaatt     2640

gtaaaagctc gcaaaatgtt ctggaaaaat ttactggatg ctaagttaat gagtcagcgt     2700

aagtatgata atttgactaa ggcagagcgc ggaggcctaa cttccgatga taaggcaaga     2760

tttatccaac gtcagttggt tgagactcga caaattacca agcatgtagc tcgtatcttg     2820

gatgaacgct tcaataatga agttgataat ggtaaaaaga tttgcaaggt taaaattgta     2880

accttgaagt caaatttggt ttcaaatttc cgaaaagaat ttggattcta taaaattcgt     2940

gaagttaatg attatcacca tgcacacgat gcttatctta atgcagtagt tgccaaagct     3000

attctaacca aatatccaca gttagagcca gagtttgtct acggaatgta tagacagaaa     3060

aaactttcga aaatcgttca tgaggataag gaagaaaaat atagtgaagc aaccaggaaa     3120

atgtttttct actccaactt gatgaatatg ttcaaaagag ttgtgaggtt agcagatggt     3180

tctattgttg taagaccagt aatagaaact ggtagatata tgagaaaaac tgcatgggat     3240

aaaaagaaac actttgcgac agttagaaaa gtcttgtcat accctcagaa caatatcgtg     3300

aagaagacag agattcagac aggtggtttc tctaaggaat caatcttggc gcatggtaac     3360

tcagataagt tgattccaag aaaaacgaag gatatttatt tagatcctaa gaaatatgga     3420

ggttttgata gtccgatagt agcttactct gttttagttg tagctgatat caaaaaaggt     3480

aaagcacaaa aactaaaaac agttacggaa cttttaggaa ttaccatcat ggagaggtcc     3540

agatttgaga aaaatccatc agctttcctt gaatcaaaag gttatttaaa tattagggac     3600

gataaattaa tgattttacc gaagtatagt ctgttcgaat tagaaaatgg gcgtcgtcga     3660

ttacttgcta gtgctggtga attacaaaaa ggtaacgagc tagccttacc aacacaattt     3720

atgaagttct tataccttgc aagtcgttat aatgagtcaa aaggtaaacc agaggagatt     3780

gagaagaaac aagaatttgt aaatcaacat gtctcttatt ttgatgacat ccttcaatta     3840

attaatgatt tttcaaaacg agttattcta gcagatgcta atttagagaa aatcaataag     3900

ctttaccagg ataataagga aaatatacca gtagatgaac ttgctaataa tattatcaat     3960

ctatttactt ttaccagtct aggagctcca gcagctttta aattttttga taaaatagtt     4020

gatagaaaac gctatacatc aactaaagaa gtacttaatt ctactctaat ccatcaatct     4080

attactggac tttatgaaac acgtattgat ttgggtaaat taggagaaga ttga           4134


<210>  216
<211>  4038
<212>  DNA
<213>  S. mutans

<400>  216
atgaaaaaac cttactctat tggacttgat attggaacca attctgttgg ttgggctgtt       60

gtgacagatg actacaaagt tcctgctaag aagatgaagg ttctgggaaa tacagataaa      120

agtcatatcg agaaaaattt gcttggcgct ttattatttg atagcgggaa tactgcagaa      180

gacagacggt taaagagaac tgctcgccgt cgttacacac gtcgcagaaa tcgtatttta      240

tatttgcaag agattttttc agaagaaatg ggcaaggtag atgatagttt ctttcatcgt      300

ttagaggatt cttttcttgt tactgaggat aaacgaggag agcgccatcc catttttggg      360

aatcttgaag aagaagttaa gtatcatgaa aattttccaa ccatttatca tttgcggcaa      420

tatcttgcgg ataatccaga aaaagttgat ttgcgtttag tttatttggc tttggcacat      480

ataattaagt ttagaggtca ttttttaatt gaaggaaagt ttgatacacg caataatgat      540

gtacaaagac tgtttcaaga atttttagca gtctatgata atacttttga gaatagttcg      600

cttcaggagc aaaatgttca agttgaagaa attctgactg ataaaatcag taaatctgct      660

aagaaagata gagttttgaa actttttcct aatgaaaagt ctaatggccg ctttgcagaa      720

tttctaaaac taattgttgg taatcaagct gattttaaaa agcattttga attagaagag      780

aaagcaccat tgcaattttc taaagatact tatgaagaag agttagaagt actattagct      840

caaattggag ataattacgc agagctcttt ttatcagcaa agaaactgta tgatagtatc      900

cttttatcag ggattttaac agttactgat gttggtacca aagcgccttt atctgcttcg      960

atgattcagc gatataatga acatcagatg gatttagctc agcttaaaca attcattcgt     1020

cagaaattat cagataaata taacgaagtt ttttctgatg tttcaaaaga cggctatgcg     1080

ggttatattg atgggaaaac aaatcaagaa gctttttata aataccttaa aggtctatta     1140

aataagattg agggaagtgg ctatttcctt gataaaattg agcgtgaaga ttttctaaga     1200

aagcaacgta cctttgacaa tggctctatt ccacatcaga ttcatcttca agaaatgcgt     1260

gctatcattc gtagacaggc tgaattttat ccgtttttag cagacaatca agataggatt     1320

gagaaattat tgactttccg tattccctac tatgttggtc cattagcgcg cggaaaaagt     1380

gattttgctt ggttaagtcg gaaatcggct gataaaatta caccatggaa ttttgatgaa     1440

atcgttgata aagaatcctc tgcagaagct tttatcaatc gtatgacaaa ttatgatttg     1500

tacttgccaa atcaaaaagt tcttcctaaa catagtttat tatacgaaaa atttactgtt     1560

tacaatgaat taacaaaggt taaatataaa acagagcaag gaaaaacagc attttttgat     1620

gccaatatga agcaagaaat ctttgatggc gtatttaagg tttatcgaaa agtaactaaa     1680

gataaattaa tggatttcct tgaaaaagaa tttgatgaat ttcgtattgt tgatttaaca     1740

ggtctggata aagaaaataa agtatttaac gcttcttatg gaacttatca tgatttgtgt     1800

aaaattttag ataaagattt tctcgataat tcaaagaatg aaaagatttt agaagatatt     1860

gtgttgacct taacgttatt tgaagataga gaaatgatta gaaaacgtct agaaaattac     1920

agtgatttat tgaccaaaga acaagtgaaa aagctggaaa gacgtcatta tactggttgg     1980

ggaagattat cagctgagtt aattcatggt attcgcaata aagaaagcag aaaaacaatt     2040

cttgattatc tcattgatga tggcaatagc aatcggaact ttatgcaact gattaacgat     2100

gatgctcttt ctttcaaaga agagattgct aaggcacaag ttattggaga aacagacaat     2160

ctaaatcaag ttgttagtga tattgctggc agccctgcta ttaaaaaagg aattttacaa     2220

agcttgaaga ttgttgatga gcttgtcaaa attatgggac atcaacctga aaatatcgtc     2280

gtggagatgg cgcgtgaaaa ccagtttacc aatcagggac gacgaaattc acagcaacgt     2340

ttgaaaggtt tgacagattc tattaaagaa tttggaagtc aaattcttaa agaacatccg     2400

gttgagaatt cacagttaca aaatgataga ttgtttctat attatttaca aaacggcaga     2460

gatatgtata ctggagaaga attggatatt gattatctaa gccagtatga tatagaccat     2520

attatcccgc aagcttttat aaaggataat tctattgata atagagtatt gactagctca     2580

aaggaaaatc gtggaaaatc ggatgatgta ccaagtaaag atgttgttcg taaaatgaaa     2640

tcctattgga gtaagctact ttcggcaaag cttattacac aacgtaaatt tgataatttg     2700

acaaaagctg aacgaggtgg attgaccgac gatgataaag ctggattcat caagcgtcaa     2760

ttagtagaaa cacgacaaat taccaaacat gtagcacgta ttctggacga acgatttaat     2820

acagaaacag atgaaaacaa caagaaaatt cgtcaagtaa aaattgtgac cttgaaatca     2880

aatcttgttt ccaatttccg taaagagttt gaactctaca aagtgcgtga aattaatgac     2940

tatcatcatg cacatgatgc ctatctcaat gctgtaattg gaaaggcttt actaggtgtt     3000

tacccacaat tggaacctga atttgtttat ggtgattatc ctcattttca tggacataaa     3060

gaaaataaag caactgctaa gaaatttttc tattcaaata ttatgaactt ctttaaaaaa     3120

gatgatgtcc gtactgataa aaatggtgaa attatctgga aaaaagatga gcatatttct     3180

aatattaaaa aagtgctttc ttatccacaa gttaatattg ttaagaaagt agaggagcaa     3240

acgggaggat tttctaaaga atctatcttg ccgaaaggta attctgacaa gcttattcct     3300

cgaaaaacga agaaatttta ttgggatacc aagaaatatg gaggatttga tagcccgatt     3360

gttgcttatt ctattttagt tattgctgat attgaaaaag gtaaatctaa aaaattgaaa     3420

acagtcaaag ccttagttgg tgtcactatt atggaaaaga tgacttttga aagggatcca     3480

gttgcttttc ttgagcgaaa aggctatcga aatgttcaag aagaaaatat tataaagtta     3540

ccaaaatata gtttatttaa actagaaaac ggacgaaaaa ggctattggc aagtgctagg     3600

gaacttcaaa agggaaatga aatcgttttg ccaaatcatt taggaacctt gctttatcac     3660

gctaaaaata ttcataaagt tgatgaacca aagcatttgg actatgttga taaacataaa     3720

gatgaattta aggagttgct agatgttgtg tcaaactttt ctaaaaaata tactttagca     3780

gaaggaaatt tagaaaaaat caaagaatta tatgcacaaa ataatggtga agatcttaaa     3840

gaattagcaa gttcatttat caacttatta acatttactg ctataggagc accggctact     3900

tttaaattct ttgataaaaa tattgatcga aaacgatata cttcaactac tgaaattctc     3960

aacgctaccc tcatccacca atccatcacc ggtctttatg aaacgcggat tgatctcaat     4020

aagttaggag gagactaa                                                   4038


<210>  217
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mprimer qADH-F

<400>  217
caagtcgcgg ttttcaatca                                                   20


<210>  218
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer qADH-R

<400>  218
tgaaggtgga agtcccaaca a                                                 21


<210>  219
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe ADH-VIC

<400>  219
tgggaagcct atctaccac                                                    19


<210>  220
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe wtEPSPS

<400>  220
cggccattga cagca                                                        15


<210>  221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer qEPSPS-F

<400>  221
tcttggggaa tgctggaact                                                   20


<210>  222
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer qEPSPSR

<400>  222
caccagcagc agtaacagct g                                                 21


<210>  223
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAM-wtEPSPS R probe

<400>  223
tgctgtcaat ggccgca                                                      17


<210>  224
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer qEPSPS-F

<400>  224
tcttggggaa tgctggaact                                                   20


<210>  225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer q wtEPSPS RA

<400>  225
ccaccagcag cagtaacagc                                                   20


<210>  226
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  orward primer q epTIPS F

<400>  226
ggaagtgcag ctcttcttgg g                                                 21


<210>  227
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer q epTIPS R

<400>  227
agctgctgtc aatgaccgc                                                    19


<210>  228
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIPS probe

<400>  228
aatgctggaa tcgca                                                        15


<210>  229
<211>  23
<212>  DNA
<213>  Zea mays


<220>
<221>  MHP14Cas1 target site
<222>  (1)..(23)

<400>  229
gttaaatctg acgtgaatct gtt                                               23


<210>  230
<211>  21
<212>  DNA
<213>  Zea mays


<220>
<221>  MHP14Cas3 target site
<222>  (1)..(21)

<400>  230
acaaacattg aagcgacata g                                                 21


<210>  231
<211>  18
<212>  DNA
<213>  Zea mays


<220>
<221>  TS8Cas1 target site
<222>  (1)..(18)

<400>  231
gtacgtaacg tgcagtac                                                     18


<210>  232
<211>  20
<212>  DNA
<213>  Zea mays


<220>
<221>  TS8Cas2 target site
<222>  (1)..(20)

<400>  232
gctcatcagt gatcagctgg                                                   20


<210>  233
<211>  17
<212>  DNA
<213>  Zea mays


<220>
<221>  TS9Cas2 target site
<222>  (1)..(17)

<400>  233
ggctgtttgc ggcctcg                                                      17


<210>  234
<211>  21
<212>  DNA
<213>  Zea mays


<220>
<221>  TS9Cas3 target site
<222>  (1)..(21)

<400>  234
gcctcgaggt tgcacgcacg t                                                 21


<210>  235
<211>  20
<212>  DNA
<213>  Zea mays


<220>
<221>  TS10Cas1 target site
<222>  (1)..(20)

<400>  235
gcctcgcctt cgctagttaa                                                   20


<210>  236
<211>  18
<212>  DNA
<213>  Zea mays


<220>
<221>  TS10Cas3 target site
<222>  (1)..(18)

<400>  236
gctcgtgttg gagataca                                                     18


<210>  237
<211>  80
<212>  DNA
<213>  Zea mays

<400>  237
gttaaatctg acgtgaatct gtttggaatt gaaaaacaag tgcttccttt catacaccac       60

tatgtcgctt caatgtttgt                                                   80


<210>  238
<211>  80
<212>  DNA
<213>  Zea mays

<400>  238
acaaacattg aagcgacata gtggtgtatg aaaggaagca cttgtttttc aattccaaac       60

agattcacgt cagatttaac                                                   80


<210>  239
<211>  66
<212>  DNA
<213>  Zea mays

<400>  239
ccagtactgc acgttacgta cgtacgaact aatatactcc accagctgat cactgatgag       60

ccgagc                                                                  66


<210>  240
<211>  66
<212>  DNA
<213>  Zea mays

<400>  240
gctcggctca tcagtgatca gctggtggag tatattagtt cgtacgtacg taacgtgcag       60

tactgg                                                                  66


<210>  241
<211>  35
<212>  DNA
<213>  Zea mays

<400>  241
ccgacgtgcg tgcaacctcg aggccgcaaa cagcc                                  35


<210>  242
<211>  35
<212>  DNA
<213>  Zea mays

<400>  242
ggctgtttgc ggcctcgagg ttgcacgcac gtcgg                                  35


<210>  243
<211>  68
<212>  DNA
<213>  Zea mays

<400>  243
gctcgtgttg gagatacagg gacagcaagt acttggccct taactagcga aggcgaggcg       60

gccatgga                                                                68


<210>  244
<211>  68
<212>  DNA
<213>  Zea mays

<400>  244
tccatggccg cctcgccttc gctagttaag ggccaagtac ttgctgtccc tgtatctcca       60

acacgagc                                                                68


<210>  245
<211>  1108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas-1 guideRNA cassette

<400>  245
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gttaaatctg acgtgaatct     1020

gttgttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa     1080

agtggcaccg agtcggtgct tttttttt                                        1108


<210>  246
<211>  1106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   MHP14Cas-3 gRNA cassette

<400>  246
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcaaacattg aagcgacata     1020

ggttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag     1080

tggcaccgag tcggtgcttt tttttt                                          1106


<210>  247
<211>  1103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-1 guideRNA cassette

<400>  247
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gtacgtaacg tgcagtacgt     1020

tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg     1080

caccgagtcg gtgctttttt ttt                                             1103


<210>  248
<211>  1105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-2 guideRNA cassette

<400>  248
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gctcatcagt gatcagctgg     1020

gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt     1080

ggcaccgagt cggtgctttt ttttt                                           1105


<210>  249
<211>  1102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-2 guideRNA cassette

<400>  249
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt ggctgtttgc ggcctcggtt     1020

ttagagctag aaatagcaag ttaaaataag gctagtccgt tatcaacttg aaaaagtggc     1080

accgagtcgg tgcttttttt tt                                              1102


<210>  250
<211>  1106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-3 guideRNA cassette

<400>  250
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcctcgaggt tgcacgcacg     1020

tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag     1080

tggcaccgag tcggtgcttt tttttt                                          1106


<210>  251
<211>  1105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-1 guideRNA cassette

<400>  251
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcctcgcctt cgctagttaa     1020

gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt     1080

ggcaccgagt cggtgctttt ttttt                                           1105


<210>  252
<211>  1103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSCas-3 guideRNA cassette

<400>  252
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gctcgtgttg gagatacagt     1020

tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg     1080

caccgagtcg gtgctttttt ttt                                             1103


<210>  253
<211>  4928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas1 donor

<400>  253
gccatgtcat cttgtagtta gggcttggag ctagtcgacc gttggaggct ttgtcctcat       60

gcggcaccgg acagtctggt gctacaccgg acagtccggt gcccctctga ccatctgctc      120

tgacatctga attgcactgt tcactttgca gagtcgacca ttgcgtgcag gtagccattg      180

ctccgctggt gcaccggaca gtccagtggc acaccggaca gtccgatgaa ttatagcgga      240

gctgcgcctg ggaaacccga agctgaggag tttgagctga ttcaccctgg tgcaccggac      300

actgtccggt ggcacactgg acagtccggt gcgccggacc agggcacact tcggtttcct      360

ttttgctcct ttcttttgaa gcctaacttg ttcttttgat tggtttgtgt tgaaccttta      420

gcacctgtag aatgtatgat ctagagcaaa ctagttagtc caattatttg tgttgggcaa      480

ttcaaccacc aaaaacattt aggaaaatgt ttgatcttat ttccctttca tattctctta      540

ttgctagttg tcggggtgaa gttgagctct tgcttaggtt ttaattagtg ttgattttta      600

gaaaaaccca attcaccccc ctcttgggca tcgtgatcct tttagcaaca aaatgtgcac      660

acatcaaaac aagcgcttct accatatgta gttgttgcac aataatggtc ctccttagga      720

tttgcaaccg tttaacaata gctatgtgac cacagattta tgtcggatgc acgaaaattg      780

taggatttta catttcttta ccttggttca caaacattga agcgacatag tggtgtatga      840

aaggaagcac ttgtttttca attccaaacc gcggtaccat ttaaatctta agcctaggat      900

aacttcgtat agcatacatt atacgaagtt atggcgccgc tagcctgcag tgcagcgtga      960

cccggtcgtg cccctctcta gagataatga gcattgcatg tctaagttat aaaaaattac     1020

cacatatttt ttttgtcaca cttgtttgaa gtgcagttta tctatcttta tacatatatt     1080

taaactttac tctacgaata atataatcta tagtactaca ataatatcag tgttttagag     1140

aatcatataa atgaacagtt agacatggtc taaaggacaa ttgagtattt tgacaacagg     1200

actctacagt tttatctttt tagtgtgcat gtgttctcct ttttttttgc aaatagcttc     1260

acctatataa tacttcatcc attttattag tacatccatt tagggtttag ggttaatggt     1320

ttttatagac taattttttt agtacatcta ttttattcta ttttagcctc taaattaaga     1380

aaactaaaac tctattttag tttttttatt taataattta gatataaaat agaataaaat     1440

aaagtgacta aaaattaaac aaataccctt taagaaatta aaaaaactaa ggaaacattt     1500

ttcttgtttc gagtagataa tgccagcctg ttaaacgccg tcgacgagtc taacggacac     1560

caaccagcga accagcagcg tcgcgtcggg ccaagcgaag cagacggcac ggcatctctg     1620

tcgctgcctc tggacccctc tcgagagttc cgctccaccg ttggacttgc tccgctgtcg     1680

gcatccagaa attgcgtggc ggagcggcag acgtgagccg gcacggcagg cggcctcctc     1740

ctcctctcac ggcaccggca gctacggggg attcctttcc caccgctcct tcgctttccc     1800

ttcctcgccc gccgtaataa atagacaccc cctccacacc ctctttcccc aacctcgtgt     1860

tgttcggagc gcacacacac acaaccagat ctcccccaaa tccacccgtc ggcacctccg     1920

cttcaaggta cgccgctcgt cctccccccc ccccctctct accttctcta gatcggcgtt     1980

ccggtccatg catggttagg gcccggtagt tctacttctg ttcatgtttg tgttagatcc     2040

gtgtttgtgt tagatccgtg ctgctagcgt tcgtacacgg atgcgacctg tacgtcagac     2100

acgttctgat tgctaacttg ccagtgtttc tctttgggga atcctgggat ggctctagcc     2160

gttccgcaga cgggatcgat ttcatgattt tttttgtttc gttgcatagg gtttggtttg     2220

cccttttcct ttatttcaat atatgccgtg cacttgtttg tcgggtcatc ttttcatgct     2280

tttttttgtc ttggttgtga tgatgtggtc tggttgggcg gtcgttctag atcggagtag     2340

aattctgttt caaactacct ggtggattta ttaattttgg atctgtatgt gtgtgccata     2400

catattcata gttacgaatt gaagatgatg gatggaaata tcgatctagg ataggtatac     2460

atgttgatgc gggttttact gatgcatata cagagatgct ttttgttcgc ttggttgtga     2520

tgatgtggtg tggttgggcg gtcgttcatt cgttctagat cggagtagaa tactgtttca     2580

aactacctgg tgtatttatt aattttggaa ctgtatgtgt gtgtcataca tcttcatagt     2640

tacgagttta agatggatgg aaatatcgat ctaggatagg tatacatgtt gatgtgggtt     2700

ttactgatgc atatacatga tggcatatgc agcatctatt catatgctct aaccttgagt     2760

acctatctat tataataaac aagtatgttt tataattatt ttgatcttga tatacttgga     2820

tgatggcata tgcagcagct atatgtggat ttttttagcc ctgccttcat acgctattta     2880

tttgcttggt actgtttctt ttgtcgatgc tcaccctgtt gtttggtgtt acttctgcag     2940

gtcgactcta gaggatcaat tcgctagcga agttcctatt ccgaagttcc tattctctag     3000

aaagtatagg aacttcagat ccaccgggat ccccgatcat gcaaaaactc attaactcag     3060

tgcaaaacta tgcctggggc agcaaaacgg cgttgactga actttatggt atggaaaatc     3120

cgtccagcca gccgatggcc gagctgtgga tgggcgcaca tccgaaaagc agttcacgag     3180

tgcagaatgc cgccggagat atcgtttcac tgcgtgatgt gattgagagt gataaatcga     3240

ctctgctcgg agaggccgtt gccaaacgct ttggcgaact gcctttcctg ttcaaagtat     3300

tatgcgcagc acagccactc tccattcagg ttcatccaaa caaacacaat tctgaaatcg     3360

gttttgccaa agaaaatgcc gcaggtatcc cgatggatgc cgccgagcgt aactataaag     3420

atcctaacca caagccggag ctggtttttg cgctgacgcc tttccttgcg atgaacgcgt     3480

ttcgtgaatt ttccgagatt gtctccctac tccagccggt cgcaggtgca catccggcga     3540

ttgctcactt tttacaacag cctgatgccg aacgtttaag cgaactgttc gccagcctgt     3600

tgaatatgca gggtgaagaa aaatcccgcg cgctggcgat tttaaaatcg gccctcgata     3660

gccagcaggg tgaaccgtgg caaacgattc gtttaatttc tgaattttac ccggaagaca     3720

gcggtctgtt ctccccgcta ttgctgaatg tggtgaaatt gaaccctggc gaagcgatgt     3780

tcctgttcgc tgaaacaccg cacgcttacc tgcaaggcgt ggcgctggaa gtgatggcaa     3840

actccgataa cgtgctgcgt gcgggtctga cgcctaaata cattgatatt ccggaactgg     3900

ttgccaatgt gaaattcgaa gccaaaccgg ctaaccagtt gttgacccag ccggtgaaac     3960

aaggtgcaga actggacttc ccgattccag tggatgattt tgccttctcg ctgcatgacc     4020

ttagtgataa agaaaccacc attagccagc agagtgccgc cattttgttc tgcgtcgaag     4080

gcgatgcaac gttgtggaaa ggttctcagc agttacagct taaaccgggt gaatcagcgt     4140

ttattgccgc caacgaatca ccggtgactg tcaaaggcca cggccgttta gcgcgtgttt     4200

acaacaagct gtaagagctt actgaaaaaa ttaacatctc ttgctaagct gggggtggaa     4260

cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat aaaaggatgc     4320

acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt tatgtgtaat     4380

tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct aaatgaatgt     4440

cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa tccatataca     4500

tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa tctagtctag     4560

gtgtgttttg cgaatgcggc cctagcgtat acgaagttcc tattccgaag ttcctattct     4620

ccagaaagta taggaacttc tgtacacctg agctgattcc gatgacttcg taggttccta     4680

gctcaagccg ctcgtgtcca agcgtcactt acgattagct aatgattacg gcatctagga     4740

ccgactagct aactaactag taccgaggcc ggccccgcgg gagctcggcg cgccagattc     4800

acgtcagatt taaccaaaac tatattatga ggtacacata ttacaatcca aaatgaatta     4860

tctagttctc gagttgtaca cagtttatca cgtgttttac acattccaac cctaaactcc     4920

aaccgtgg                                                              4928


<210>  254
<211>  4570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas3 donor

<400>  254
acacttcggt ttcctttttg ctcctttctt ttgaagccta acttgttctt ttgattggtt       60

tgtgttgaac ctttagcacc tgtagaatgt atgatctaga gcaaactagt tagtccaatt      120

atttgtgttg ggcaattcaa ccaccaaaaa catttaggaa aatgtttgat cttatttccc      180

tttcatattc tcttattgct agttgtcggg gtgaagttga gctcttgctt aggttttaat      240

tagtgttgat ttttagaaaa acccaattca cccccctctt gggcatcgtg atccttttag      300

caacaaaatg tgcacacatc aaaacaagcg cttctaccat atgtagttgt tgcacaataa      360

tggtcctcct taggatttgc aaccgtttaa caatagctat gtgaccacag atttatgtcg      420

gatgcacgaa aattgtagga ttttacattt ctttaccttg gttcacaaac attgaagcga      480

caggtaccat ttaaatctta agcctaggat aacttcgtat agcatacatt atacgaagtt      540

atggcgccgc tagcctgcag tgcagcgtga cccggtcgtg cccctctcta gagataatga      600

gcattgcatg tctaagttat aaaaaattac cacatatttt ttttgtcaca cttgtttgaa      660

gtgcagttta tctatcttta tacatatatt taaactttac tctacgaata atataatcta      720

tagtactaca ataatatcag tgttttagag aatcatataa atgaacagtt agacatggtc      780

taaaggacaa ttgagtattt tgacaacagg actctacagt tttatctttt tagtgtgcat      840

gtgttctcct ttttttttgc aaatagcttc acctatataa tacttcatcc attttattag      900

tacatccatt tagggtttag ggttaatggt ttttatagac taattttttt agtacatcta      960

ttttattcta ttttagcctc taaattaaga aaactaaaac tctattttag tttttttatt     1020

taataattta gatataaaat agaataaaat aaagtgacta aaaattaaac aaataccctt     1080

taagaaatta aaaaaactaa ggaaacattt ttcttgtttc gagtagataa tgccagcctg     1140

ttaaacgccg tcgacgagtc taacggacac caaccagcga accagcagcg tcgcgtcggg     1200

ccaagcgaag cagacggcac ggcatctctg tcgctgcctc tggacccctc tcgagagttc     1260

cgctccaccg ttggacttgc tccgctgtcg gcatccagaa attgcgtggc ggagcggcag     1320

acgtgagccg gcacggcagg cggcctcctc ctcctctcac ggcaccggca gctacggggg     1380

attcctttcc caccgctcct tcgctttccc ttcctcgccc gccgtaataa atagacaccc     1440

cctccacacc ctctttcccc aacctcgtgt tgttcggagc gcacacacac acaaccagat     1500

ctcccccaaa tccacccgtc ggcacctccg cttcaaggta cgccgctcgt cctccccccc     1560

ccccctctct accttctcta gatcggcgtt ccggtccatg catggttagg gcccggtagt     1620

tctacttctg ttcatgtttg tgttagatcc gtgtttgtgt tagatccgtg ctgctagcgt     1680

tcgtacacgg atgcgacctg tacgtcagac acgttctgat tgctaacttg ccagtgtttc     1740

tctttgggga atcctgggat ggctctagcc gttccgcaga cgggatcgat ttcatgattt     1800

tttttgtttc gttgcatagg gtttggtttg cccttttcct ttatttcaat atatgccgtg     1860

cacttgtttg tcgggtcatc ttttcatgct tttttttgtc ttggttgtga tgatgtggtc     1920

tggttgggcg gtcgttctag atcggagtag aattctgttt caaactacct ggtggattta     1980

ttaattttgg atctgtatgt gtgtgccata catattcata gttacgaatt gaagatgatg     2040

gatggaaata tcgatctagg ataggtatac atgttgatgc gggttttact gatgcatata     2100

cagagatgct ttttgttcgc ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt     2160

cgttctagat cggagtagaa tactgtttca aactacctgg tgtatttatt aattttggaa     2220

ctgtatgtgt gtgtcataca tcttcatagt tacgagttta agatggatgg aaatatcgat     2280

ctaggatagg tatacatgtt gatgtgggtt ttactgatgc atatacatga tggcatatgc     2340

agcatctatt catatgctct aaccttgagt acctatctat tataataaac aagtatgttt     2400

tataattatt ttgatcttga tatacttgga tgatggcata tgcagcagct atatgtggat     2460

ttttttagcc ctgccttcat acgctattta tttgcttggt actgtttctt ttgtcgatgc     2520

tcaccctgtt gtttggtgtt acttctgcag gtcgactcta gaggatcaat tcgctagcga     2580

agttcctatt ccgaagttcc tattctctag aaagtatagg aacttcagat ccaccgggat     2640

ccccgatcat gcaaaaactc attaactcag tgcaaaacta tgcctggggc agcaaaacgg     2700

cgttgactga actttatggt atggaaaatc cgtccagcca gccgatggcc gagctgtgga     2760

tgggcgcaca tccgaaaagc agttcacgag tgcagaatgc cgccggagat atcgtttcac     2820

tgcgtgatgt gattgagagt gataaatcga ctctgctcgg agaggccgtt gccaaacgct     2880

ttggcgaact gcctttcctg ttcaaagtat tatgcgcagc acagccactc tccattcagg     2940

ttcatccaaa caaacacaat tctgaaatcg gttttgccaa agaaaatgcc gcaggtatcc     3000

cgatggatgc cgccgagcgt aactataaag atcctaacca caagccggag ctggtttttg     3060

cgctgacgcc tttccttgcg atgaacgcgt ttcgtgaatt ttccgagatt gtctccctac     3120

tccagccggt cgcaggtgca catccggcga ttgctcactt tttacaacag cctgatgccg     3180

aacgtttaag cgaactgttc gccagcctgt tgaatatgca gggtgaagaa aaatcccgcg     3240

cgctggcgat tttaaaatcg gccctcgata gccagcaggg tgaaccgtgg caaacgattc     3300

gtttaatttc tgaattttac ccggaagaca gcggtctgtt ctccccgcta ttgctgaatg     3360

tggtgaaatt gaaccctggc gaagcgatgt tcctgttcgc tgaaacaccg cacgcttacc     3420

tgcaaggcgt ggcgctggaa gtgatggcaa actccgataa cgtgctgcgt gcgggtctga     3480

cgcctaaata cattgatatt ccggaactgg ttgccaatgt gaaattcgaa gccaaaccgg     3540

ctaaccagtt gttgacccag ccggtgaaac aaggtgcaga actggacttc ccgattccag     3600

tggatgattt tgccttctcg ctgcatgacc ttagtgataa agaaaccacc attagccagc     3660

agagtgccgc cattttgttc tgcgtcgaag gcgatgcaac gttgtggaaa ggttctcagc     3720

agttacagct taaaccgggt gaatcagcgt ttattgccgc caacgaatca ccggtgactg     3780

tcaaaggcca cggccgttta gcgcgtgttt acaacaagct gtaagagctt actgaaaaaa     3840

ttaacatctc ttgctaagct gggggtggaa cctagacttg tccatcttct ggattggcca     3900

acttaattaa tgtatgaaat aaaaggatgc acacatagtg acatgctaat cactataatg     3960

tgggcatcaa agttgtgtgt tatgtgtaat tactagttat ctgaataaaa gagaaagaga     4020

tcatccatat ttcttatcct aaatgaatgt cacgtgtctt tataattctt tgatgaacca     4080

gatgcatttc attaaccaaa tccatataca tataaatatt aatcatatat aattaatatc     4140

aattgggtta gcaaaacaaa tctagtctag gtgtgttttg cgaatgcggc cctagcgtat     4200

acgaagttcc tattccgaag ttcctattct ccagaaagta taggaacttc tgtacacctg     4260

agctgattcc gatgacttcg taggttccta gctcaagccg ctcgtgtcca agcgtcactt     4320

acgattagct aatgattacg gcatctagga ccgactagct aactaactag taccgaggcc     4380

ggccccgcgg gagctcggcg cgcctagtgg tgtatgaaag gaagcacttg tttttcaatt     4440

ccaaacagat tcacgtcaga tttaaccaaa actatattat gaggtacaca tattacaatc     4500

caaaatgaat tatctagttc tcgagttgta cacagtttat cacgtgtttt acacattcca     4560

accctaaact                                                            4570


<210>  255
<211>  5091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-1 donor

<400>  255
cacacatgac tgcctgagaa tctgctgccg ttgcctctca tattatattc gatcccctga       60

ctaaaaaaac tcggggccgg ctaatacgta ctgtacgtac gcagaattta cggtccagca      120

cgggcatgcc gcgcgggctg actttgctcc actgactcga tcatgtgcgg attccatcgc      180

ggcgtagcgt agccaaccgc aacgcaaacc gacttcatct ttttttttta ttatgaacaa      240

aaggagatcg agagaaacgt gaacggtaaa taatatatct gatcccatgc atgcacgctg      300

cctgggtcga tctcgctctc gctccgccca gacgaacatg catgctggtc aggctcaacg      360

ctcaggcggg caagctgtgg gaggacatgg gatgggagag gaggacacat gcatgctggc      420

cagtcaggca ctgtgctggc acatgaggta gggatagggg ggccctcggc cagtgtccag      480

gccgcatgca tgcatgcccc ccctgctgct cgaccgaaca acgttggatg cctggattga      540

tgcaacagtt tggacggacg gaccatacgt tatgtaccag taggtaccat ttaaatctta      600

agcctaggat aacttcgtat agcatacatt atacgaagtt atggcgccgc tagcctgcag      660

tgcagcgtga cccggtcgtg cccctctcta gagataatga gcattgcatg tctaagttat      720

aaaaaattac cacatatttt ttttgtcaca cttgtttgaa gtgcagttta tctatcttta      780

tacatatatt taaactttac tctacgaata atataatcta tagtactaca ataatatcag      840

tgttttagag aatcatataa atgaacagtt agacatggtc taaaggacaa ttgagtattt      900

tgacaacagg actctacagt tttatctttt tagtgtgcat gtgttctcct ttttttttgc      960

aaatagcttc acctatataa tacttcatcc attttattag tacatccatt tagggtttag     1020

ggttaatggt ttttatagac taattttttt agtacatcta ttttattcta ttttagcctc     1080

taaattaaga aaactaaaac tctattttag tttttttatt taataattta gatataaaat     1140

agaataaaat aaagtgacta aaaattaaac aaataccctt taagaaatta aaaaaactaa     1200

ggaaacattt ttcttgtttc gagtagataa tgccagcctg ttaaacgccg tcgacgagtc     1260

taacggacac caaccagcga accagcagcg tcgcgtcggg ccaagcgaag cagacggcac     1320

ggcatctctg tcgctgcctc tggacccctc tcgagagttc cgctccaccg ttggacttgc     1380

tccgctgtcg gcatccagaa attgcgtggc ggagcggcag acgtgagccg gcacggcagg     1440

cggcctcctc ctcctctcac ggcaccggca gctacggggg attcctttcc caccgctcct     1500

tcgctttccc ttcctcgccc gccgtaataa atagacaccc cctccacacc ctctttcccc     1560

aacctcgtgt tgttcggagc gcacacacac acaaccagat ctcccccaaa tccacccgtc     1620

ggcacctccg cttcaaggta cgccgctcgt cctccccccc ccccctctct accttctcta     1680

gatcggcgtt ccggtccatg catggttagg gcccggtagt tctacttctg ttcatgtttg     1740

tgttagatcc gtgtttgtgt tagatccgtg ctgctagcgt tcgtacacgg atgcgacctg     1800

tacgtcagac acgttctgat tgctaacttg ccagtgtttc tctttgggga atcctgggat     1860

ggctctagcc gttccgcaga cgggatcgat ttcatgattt tttttgtttc gttgcatagg     1920

gtttggtttg cccttttcct ttatttcaat atatgccgtg cacttgtttg tcgggtcatc     1980

ttttcatgct tttttttgtc ttggttgtga tgatgtggtc tggttgggcg gtcgttctag     2040

atcggagtag aattctgttt caaactacct ggtggattta ttaattttgg atctgtatgt     2100

gtgtgccata catattcata gttacgaatt gaagatgatg gatggaaata tcgatctagg     2160

ataggtatac atgttgatgc gggttttact gatgcatata cagagatgct ttttgttcgc     2220

ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt cgttctagat cggagtagaa     2280

tactgtttca aactacctgg tgtatttatt aattttggaa ctgtatgtgt gtgtcataca     2340

tcttcatagt tacgagttta agatggatgg aaatatcgat ctaggatagg tatacatgtt     2400

gatgtgggtt ttactgatgc atatacatga tggcatatgc agcatctatt catatgctct     2460

aaccttgagt acctatctat tataataaac aagtatgttt tataattatt ttgatcttga     2520

tatacttgga tgatggcata tgcagcagct atatgtggat ttttttagcc ctgccttcat     2580

acgctattta tttgcttggt actgtttctt ttgtcgatgc tcaccctgtt gtttggtgtt     2640

acttctgcag gtcgactcta gaggatcaat tcgctagcga agttcctatt ccgaagttcc     2700

tattctctag aaagtatagg aacttcagat ccaccgggat ccccgatcat gcaaaaactc     2760

attaactcag tgcaaaacta tgcctggggc agcaaaacgg cgttgactga actttatggt     2820

atggaaaatc cgtccagcca gccgatggcc gagctgtgga tgggcgcaca tccgaaaagc     2880

agttcacgag tgcagaatgc cgccggagat atcgtttcac tgcgtgatgt gattgagagt     2940

gataaatcga ctctgctcgg agaggccgtt gccaaacgct ttggcgaact gcctttcctg     3000

ttcaaagtat tatgcgcagc acagccactc tccattcagg ttcatccaaa caaacacaat     3060

tctgaaatcg gttttgccaa agaaaatgcc gcaggtatcc cgatggatgc cgccgagcgt     3120

aactataaag atcctaacca caagccggag ctggtttttg cgctgacgcc tttccttgcg     3180

atgaacgcgt ttcgtgaatt ttccgagatt gtctccctac tccagccggt cgcaggtgca     3240

catccggcga ttgctcactt tttacaacag cctgatgccg aacgtttaag cgaactgttc     3300

gccagcctgt tgaatatgca gggtgaagaa aaatcccgcg cgctggcgat tttaaaatcg     3360

gccctcgata gccagcaggg tgaaccgtgg caaacgattc gtttaatttc tgaattttac     3420

ccggaagaca gcggtctgtt ctccccgcta ttgctgaatg tggtgaaatt gaaccctggc     3480

gaagcgatgt tcctgttcgc tgaaacaccg cacgcttacc tgcaaggcgt ggcgctggaa     3540

gtgatggcaa actccgataa cgtgctgcgt gcgggtctga cgcctaaata cattgatatt     3600

ccggaactgg ttgccaatgt gaaattcgaa gccaaaccgg ctaaccagtt gttgacccag     3660

ccggtgaaac aaggtgcaga actggacttc ccgattccag tggatgattt tgccttctcg     3720

ctgcatgacc ttagtgataa agaaaccacc attagccagc agagtgccgc cattttgttc     3780

tgcgtcgaag gcgatgcaac gttgtggaaa ggttctcagc agttacagct taaaccgggt     3840

gaatcagcgt ttattgccgc caacgaatca ccggtgactg tcaaaggcca cggccgttta     3900

gcgcgtgttt acaacaagct gtaagagctt actgaaaaaa ttaacatctc ttgctaagct     3960

gggggtggaa cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat     4020

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt     4080

tatgtgtaat tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct     4140

aaatgaatgt cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa     4200

tccatataca tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa     4260

tctagtctag gtgtgttttg cgaatgcggc cctagcgtat acgaagttcc tattccgaag     4320

ttcctattct ccagaaagta taggaacttc tgtacacctg agctgattcc gatgacttcg     4380

taggttccta gctcaagccg ctcgtgtcca agcgtcactt acgattagct aatgattacg     4440

gcatctagga ccgactagct aactaactag taccgaggcc ggccccgcgg actgcacgtt     4500

acgtacgtac gaactaatat actccaccag ctgatcactg atgagccgag ccgccatgca     4560

ttgtaattta taacatgtgc ggctgtacgc ttccatctca aatacctttt tatatatata     4620

ttgtacttta tagtctacga cataatctgc catggtaatt tataagatgt gctttattgc     4680

tcgttgttct gttctcatct gtgtccatgg catggcatgg atacaaaatg tatgtatggc     4740

cacgcatcca atctgtgacg ttgtcaaggc agaggtccaa ccgtccaaga ccctcttgtg     4800

ccgccctgta cttgcagtca gtgacgttgt gagaaaaagc tgtgggtggt ctccgcagag     4860

cgcgcgggcc acgagaggga gccccatctc tcggccgagg ggtacggggg ctccagacac     4920

ggtcctttgg tttcttctgc ctgtagcgag cggccccgcc ccccaccgcg ctgctagcct     4980

agccgatgct gatccatcca ccacccacaa gggattgttc cacgacttgt ggacctgacc     5040

atgacgtgac ttcacgccat gtacgctcag ccgctcacta gctttttttt c              5091


<210>  256
<211>  5237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-2 donor

<400>  256
tctctttcag ggcttgttcg tttacgttgg attgcacccg gaatcgttac agctaatcaa       60

agtttatata aattagagaa gcaaccggat aggaatcgtt ccgacccacc aattcgacac      120

aaacgaacaa ggcctcaatc cttctcaatc cacctccaac ccaataagct cttggaggcg      180

gcggcgggag agcagccaca cacatgactg cctgagaatc tgctgccgtt gcctctcata      240

ttatattcga tcccctgact aaaaaaactc ggggccggct aatacgtact gtacgtacgc      300

agaatttacg gtccagcacg ggcatgccgc gcgggctgac tttgctccac tgactcgatc      360

atgtgcggat tccatcgcgg cgtagcgtag ccaaccgcaa cgcaaaccga cttcatcttt      420

tttttttatt atgaacaaaa ggagatcgag agaaacgtga acggtaaata atatatctga      480

tcccatgcat gcacgctgcc tgggtcgatc tcgctctcgc tccgcccaga cgaacatgca      540

tgctggtcag gctcaacgct caggcgggca agctgtggga ggacatggga tgggagagga      600

ggacacatgc atgctggcca gtcaggcact gtgctggcac atgaggtagg gatagggggg      660

ccctcggcca gtgtccaggc cgcatgcatg catgcccccc ctgctgctcg accgaacaac      720

gttggatgcc tggattgatg caacagtttg gacggacgga ccatacgtta tgtaccagta      780

ctgcacgtta cgtacgtacg aactaatata ctccaccagg taccatttaa atcttaagcc      840

taggataact tcgtatagca tacattatac gaagttatgg cgccgctagc ctgcagtgca      900

gcgtgacccg gtcgtgcccc tctctagaga taatgagcat tgcatgtcta agttataaaa      960

aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta tctttataca     1020

tatatttaaa ctttactcta cgaataatat aatctatagt actacaataa tatcagtgtt     1080

ttagagaatc atataaatga acagttagac atggtctaaa ggacaattga gtattttgac     1140

aacaggactc tacagtttta tctttttagt gtgcatgtgt tctccttttt ttttgcaaat     1200

agcttcacct atataatact tcatccattt tattagtaca tccatttagg gtttagggtt     1260

aatggttttt atagactaat ttttttagta catctatttt attctatttt agcctctaaa     1320

ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata taaaatagaa     1380

taaaataaag tgactaaaaa ttaaacaaat accctttaag aaattaaaaa aactaaggaa     1440

acatttttct tgtttcgagt agataatgcc agcctgttaa acgccgtcga cgagtctaac     1500

ggacaccaac cagcgaacca gcagcgtcgc gtcgggccaa gcgaagcaga cggcacggca     1560

tctctgtcgc tgcctctgga cccctctcga gagttccgct ccaccgttgg acttgctccg     1620

ctgtcggcat ccagaaattg cgtggcggag cggcagacgt gagccggcac ggcaggcggc     1680

ctcctcctcc tctcacggca ccggcagcta cgggggattc ctttcccacc gctccttcgc     1740

tttcccttcc tcgcccgccg taataaatag acaccccctc cacaccctct ttccccaacc     1800

tcgtgttgtt cggagcgcac acacacacaa ccagatctcc cccaaatcca cccgtcggca     1860

cctccgcttc aaggtacgcc gctcgtcctc cccccccccc ctctctacct tctctagatc     1920

ggcgttccgg tccatgcatg gttagggccc ggtagttcta cttctgttca tgtttgtgtt     1980

agatccgtgt ttgtgttaga tccgtgctgc tagcgttcgt acacggatgc gacctgtacg     2040

tcagacacgt tctgattgct aacttgccag tgtttctctt tggggaatcc tgggatggct     2100

ctagccgttc cgcagacggg atcgatttca tgattttttt tgtttcgttg catagggttt     2160

ggtttgccct tttcctttat ttcaatatat gccgtgcact tgtttgtcgg gtcatctttt     2220

catgcttttt tttgtcttgg ttgtgatgat gtggtctggt tgggcggtcg ttctagatcg     2280

gagtagaatt ctgtttcaaa ctacctggtg gatttattaa ttttggatct gtatgtgtgt     2340

gccatacata ttcatagtta cgaattgaag atgatggatg gaaatatcga tctaggatag     2400

gtatacatgt tgatgcgggt tttactgatg catatacaga gatgcttttt gttcgcttgg     2460

ttgtgatgat gtggtgtggt tgggcggtcg ttcattcgtt ctagatcgga gtagaatact     2520

gtttcaaact acctggtgta tttattaatt ttggaactgt atgtgtgtgt catacatctt     2580

catagttacg agtttaagat ggatggaaat atcgatctag gataggtata catgttgatg     2640

tgggttttac tgatgcatat acatgatggc atatgcagca tctattcata tgctctaacc     2700

ttgagtacct atctattata ataaacaagt atgttttata attattttga tcttgatata     2760

cttggatgat ggcatatgca gcagctatat gtggattttt ttagccctgc cttcatacgc     2820

tatttatttg cttggtactg tttcttttgt cgatgctcac cctgttgttt ggtgttactt     2880

ctgcaggtcg actctagagg atcaattcgc tagcgaagtt cctattccga agttcctatt     2940

ctctagaaag tataggaact tcagatccac cgggatcccc gatcatgcaa aaactcatta     3000

actcagtgca aaactatgcc tggggcagca aaacggcgtt gactgaactt tatggtatgg     3060

aaaatccgtc cagccagccg atggccgagc tgtggatggg cgcacatccg aaaagcagtt     3120

cacgagtgca gaatgccgcc ggagatatcg tttcactgcg tgatgtgatt gagagtgata     3180

aatcgactct gctcggagag gccgttgcca aacgctttgg cgaactgcct ttcctgttca     3240

aagtattatg cgcagcacag ccactctcca ttcaggttca tccaaacaaa cacaattctg     3300

aaatcggttt tgccaaagaa aatgccgcag gtatcccgat ggatgccgcc gagcgtaact     3360

ataaagatcc taaccacaag ccggagctgg tttttgcgct gacgcctttc cttgcgatga     3420

acgcgtttcg tgaattttcc gagattgtct ccctactcca gccggtcgca ggtgcacatc     3480

cggcgattgc tcacttttta caacagcctg atgccgaacg tttaagcgaa ctgttcgcca     3540

gcctgttgaa tatgcagggt gaagaaaaat cccgcgcgct ggcgatttta aaatcggccc     3600

tcgatagcca gcagggtgaa ccgtggcaaa cgattcgttt aatttctgaa ttttacccgg     3660

aagacagcgg tctgttctcc ccgctattgc tgaatgtggt gaaattgaac cctggcgaag     3720

cgatgttcct gttcgctgaa acaccgcacg cttacctgca aggcgtggcg ctggaagtga     3780

tggcaaactc cgataacgtg ctgcgtgcgg gtctgacgcc taaatacatt gatattccgg     3840

aactggttgc caatgtgaaa ttcgaagcca aaccggctaa ccagttgttg acccagccgg     3900

tgaaacaagg tgcagaactg gacttcccga ttccagtgga tgattttgcc ttctcgctgc     3960

atgaccttag tgataaagaa accaccatta gccagcagag tgccgccatt ttgttctgcg     4020

tcgaaggcga tgcaacgttg tggaaaggtt ctcagcagtt acagcttaaa ccgggtgaat     4080

cagcgtttat tgccgccaac gaatcaccgg tgactgtcaa aggccacggc cgtttagcgc     4140

gtgtttacaa caagctgtaa gagcttactg aaaaaattaa catctcttgc taagctgggg     4200

gtggaaccta gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa     4260

ggatgcacac atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg     4320

tgtaattact agttatctga ataaaagaga aagagatcat ccatatttct tatcctaaat     4380

gaatgtcacg tgtctttata attctttgat gaaccagatg catttcatta accaaatcca     4440

tatacatata aatattaatc atatataatt aatatcaatt gggttagcaa aacaaatcta     4500

gtctaggtgt gttttgcgaa tgcggcccta gcgtatacga agttcctatt ccgaagttcc     4560

tattctccag aaagtatagg aacttctgta cacctgagct gattccgatg acttcgtagg     4620

ttcctagctc aagccgctcg tgtccaagcg tcacttacga ttagctaatg attacggcat     4680

ctaggaccga ctagctaact aactagtacc gaggccggcc ccgcgggagc tcgctgatca     4740

ctgatgagcc gagccgccat gcattgtaat ttataacatg tgcggctgta cgcttccatc     4800

tcaaatacct ttttatatat atattgtact ttatagtcta cgacataatc tgccatggta     4860

atttataaga tgtgctttat tgctcgttgt tctgttctca tctgtgtcca tggcatggca     4920

tggatacaaa atgtatgtat ggccacgcat ccaatctgtg acgttgtcaa ggcagaggtc     4980

caaccgtcca agaccctctt gtgccgccct gtacttgcag tcagtgacgt tgtgagaaaa     5040

agctgtgggt ggtctccgca gagcgcgcgg gccacgagag ggagccccat ctctcggccg     5100

aggggtacgg gggctccaga cacggtcctt tggtttcttc tgcctgtagc gagcggcccc     5160

gccccccacc gcgctgctag cctagccgat gctgatccat ccaccaccca caagggattg     5220

ttccacgact tgtggac                                                    5237


<210>  257
<211>  5427
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-2 donor

<400>  257
agcaaggaac taaactgtta ttggacgcta aagtttagta ctttatcttt aacatctttc       60

agcatttcta tgtagatatt taagggctaa attttagcaa gtgtgctgat aaattttagc      120

ctaaatgttt ctgttgggct aaattttagc aagtgtactg ttaaatttta gcatattcct      180

tttagagtgg tatgggtgtg catagactaa atgtttccgt tgggccctaa tttaacgatg      240

tgtacgcagg cctgtttaga tgacttggta ccggcatatg gcctcgtact gtttcatttg      300

atgacgcgag cgtgcggccc atgcagcagc agcacgccgg gaaggcagcg gattttgaag      360

tactattgga cagcgcggcg cggggaccgg gtcgttggcg cgcggtggag tgggggtggg      420

tggtcctggc gtcctgccct gcgcgatggt cgatggatgc cccatgcgcg tgtaaccgcc      480

cagccgtcgc catccgacca ggtgggcaga cgtacgtacg gtggcacgcc cacggcccat      540

cggccatcgc gatcgcgttc gtatcgtgtc ctcaataacg aaagcgccaa cggaaggcgc      600

tgtcgtcgtc agttcaccgc gcgccggcgc cctgtgtcct cgtccctctc gacttctcga      660

ccagtaagaa ctctcgcgag ctgcggagct gctggcgatg gccggccggt gggatccgac      720

gtgcgtgcaa cctcgaattt aaatcttaag cctaggataa cttcgtatag catacattat      780

acgaagttat ggcgccgcta gcctgcagtg cagcgtgacc cggtcgtgcc cctctctaga      840

gataatgagc attgcatgtc taagttataa aaaattacca catatttttt ttgtcacact      900

tgtttgaagt gcagtttatc tatctttata catatattta aactttactc tacgaataat      960

ataatctata gtactacaat aatatcagtg ttttagagaa tcatataaat gaacagttag     1020

acatggtcta aaggacaatt gagtattttg acaacaggac tctacagttt tatcttttta     1080

gtgtgcatgt gttctccttt ttttttgcaa atagcttcac ctatataata cttcatccat     1140

tttattagta catccattta gggtttaggg ttaatggttt ttatagacta atttttttag     1200

tacatctatt ttattctatt ttagcctcta aattaagaaa actaaaactc tattttagtt     1260

tttttattta ataatttaga tataaaatag aataaaataa agtgactaaa aattaaacaa     1320

atacccttta agaaattaaa aaaactaagg aaacattttt cttgtttcga gtagataatg     1380

ccagcctgtt aaacgccgtc gacgagtcta acggacacca accagcgaac cagcagcgtc     1440

gcgtcgggcc aagcgaagca gacggcacgg catctctgtc gctgcctctg gacccctctc     1500

gagagttccg ctccaccgtt ggacttgctc cgctgtcggc atccagaaat tgcgtggcgg     1560

agcggcagac gtgagccggc acggcaggcg gcctcctcct cctctcacgg caccggcagc     1620

tacgggggat tcctttccca ccgctccttc gctttccctt cctcgcccgc cgtaataaat     1680

agacaccccc tccacaccct ctttccccaa cctcgtgttg ttcggagcgc acacacacac     1740

aaccagatct cccccaaatc cacccgtcgg cacctccgct tcaaggtacg ccgctcgtcc     1800

tccccccccc ccctctctac cttctctaga tcggcgttcc ggtccatgca tggttagggc     1860

ccggtagttc tacttctgtt catgtttgtg ttagatccgt gtttgtgtta gatccgtgct     1920

gctagcgttc gtacacggat gcgacctgta cgtcagacac gttctgattg ctaacttgcc     1980

agtgtttctc tttggggaat cctgggatgg ctctagccgt tccgcagacg ggatcgattt     2040

catgattttt tttgtttcgt tgcatagggt ttggtttgcc cttttccttt atttcaatat     2100

atgccgtgca cttgtttgtc gggtcatctt ttcatgcttt tttttgtctt ggttgtgatg     2160

atgtggtctg gttgggcggt cgttctagat cggagtagaa ttctgtttca aactacctgg     2220

tggatttatt aattttggat ctgtatgtgt gtgccataca tattcatagt tacgaattga     2280

agatgatgga tggaaatatc gatctaggat aggtatacat gttgatgcgg gttttactga     2340

tgcatataca gagatgcttt ttgttcgctt ggttgtgatg atgtggtgtg gttgggcggt     2400

cgttcattcg ttctagatcg gagtagaata ctgtttcaaa ctacctggtg tatttattaa     2460

ttttggaact gtatgtgtgt gtcatacatc ttcatagtta cgagtttaag atggatggaa     2520

atatcgatct aggataggta tacatgttga tgtgggtttt actgatgcat atacatgatg     2580

gcatatgcag catctattca tatgctctaa ccttgagtac ctatctatta taataaacaa     2640

gtatgtttta taattatttt gatcttgata tacttggatg atggcatatg cagcagctat     2700

atgtggattt ttttagccct gccttcatac gctatttatt tgcttggtac tgtttctttt     2760

gtcgatgctc accctgttgt ttggtgttac ttctgcaggt cgactctaga ggatcaattc     2820

gctagcgaag ttcctattcc gaagttccta ttctctagaa agtataggaa cttcagatcc     2880

accgggatcc ccgatcatgc aaaaactcat taactcagtg caaaactatg cctggggcag     2940

caaaacggcg ttgactgaac tttatggtat ggaaaatccg tccagccagc cgatggccga     3000

gctgtggatg ggcgcacatc cgaaaagcag ttcacgagtg cagaatgccg ccggagatat     3060

cgtttcactg cgtgatgtga ttgagagtga taaatcgact ctgctcggag aggccgttgc     3120

caaacgcttt ggcgaactgc ctttcctgtt caaagtatta tgcgcagcac agccactctc     3180

cattcaggtt catccaaaca aacacaattc tgaaatcggt tttgccaaag aaaatgccgc     3240

aggtatcccg atggatgccg ccgagcgtaa ctataaagat cctaaccaca agccggagct     3300

ggtttttgcg ctgacgcctt tccttgcgat gaacgcgttt cgtgaatttt ccgagattgt     3360

ctccctactc cagccggtcg caggtgcaca tccggcgatt gctcactttt tacaacagcc     3420

tgatgccgaa cgtttaagcg aactgttcgc cagcctgttg aatatgcagg gtgaagaaaa     3480

atcccgcgcg ctggcgattt taaaatcggc cctcgatagc cagcagggtg aaccgtggca     3540

aacgattcgt ttaatttctg aattttaccc ggaagacagc ggtctgttct ccccgctatt     3600

gctgaatgtg gtgaaattga accctggcga agcgatgttc ctgttcgctg aaacaccgca     3660

cgcttacctg caaggcgtgg cgctggaagt gatggcaaac tccgataacg tgctgcgtgc     3720

gggtctgacg cctaaataca ttgatattcc ggaactggtt gccaatgtga aattcgaagc     3780

caaaccggct aaccagttgt tgacccagcc ggtgaaacaa ggtgcagaac tggacttccc     3840

gattccagtg gatgattttg ccttctcgct gcatgacctt agtgataaag aaaccaccat     3900

tagccagcag agtgccgcca ttttgttctg cgtcgaaggc gatgcaacgt tgtggaaagg     3960

ttctcagcag ttacagctta aaccgggtga atcagcgttt attgccgcca acgaatcacc     4020

ggtgactgtc aaaggccacg gccgtttagc gcgtgtttac aacaagctgt aagagcttac     4080

tgaaaaaatt aacatctctt gctaagctgg gggtggaacc tagacttgtc catcttctgg     4140

attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac atgctaatca     4200

ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct gaataaaaga     4260

gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta taattctttg     4320

atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa tcatatataa     4380

ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg aatgcggccc     4440

tagcgtatac gaagttccta ttccgaagtt cctattctcc agaaagtata ggaacttctg     4500

tacacctgag ctgattccga tgacttcgta ggttcctagc tcaagccgct cgtgtccaag     4560

cgtcacttac gattagctaa tgattacggc atctaggacc gactagctaa ctaactagta     4620

ccgaggccgg ccccgcggga gctcggccgc aaacagcctg gtgacagacg aagccagcaa     4680

gcacgtacgt acgcacgtct ctgctggtct ggatgtgtat ggatatggac gtctcacgtc     4740

tggacgtcgt cgtcgccgtt gtattgtatc atgccaacca cttccgtacc gtaccccctc     4800

gcgtgccaac atgaccaccg ccggtacgtc tccatcgtcg gccgtcggcg tctcaggcag     4860

ctctcaatta agcggacgtg ttttggtaat ctggtggaac gccgcgcgca ctgagggttt     4920

gggggccccg gcggacgagc gagcgagaga cggtgcatgc atgccaaatg gcaacgaggg     4980

cccgcccgcc catccaataa ccaacccaga cgtagcgcaa ccaacgtacg agtcctgtgc     5040

tggcgcgtac gactaccacg ctagctgccg cgacatgcga actacggtcc accaggcacc     5100

agccatgaca atatatactg tatatatatt tttcttcttc tttttgtttc cgctctctca     5160

agttcctgct ctgctcctgc ctgtccgcgg tgccgatcgg cgagagagca tgcatggaca     5220

tggaccacgc gagatccagg aaccggcacg ggcccatgcg tggcaggcgg ccgtttcgtc     5280

aggttccccg aaatgcccca actgcgcggc tgcaggatgg ctcatggctg gctgcctagc     5340

tggcccgtga caccgatcga tcggtaacga cgacgcacgc acctgaagca caggaaggag     5400

cctccctctc gcatgcacgt tagtact                                         5427


<210>  258
<211>  5426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-3 donor

<400>  258
agcaaggaac taaactgtta ttggacgcaa agtttagtac tttatcttta acatctttca       60

gcatttctat gtagatattt aagggctaaa ttttagcaag tgtgctgata aattttagcc      120

taaatgtttc tgttgggcta aattttagca agtgtactgt taaattttag catattcctt      180

ttagagtggt atgggtgtgc atagactaaa tgtttccgtt gggccctaat ttaacgatgt      240

gtacgcaggc ctgtttagat gacttggtac cggcatatgg cctcgtactg tttcatttga      300

tgacgcgagc gtgcggccca tgcagcagca gcacgccggg aaggcagcgg attttgaagt      360

actattggac agcgcggcgc ggggaccggg tcgttggcgc gcggtggagt gggggtgggt      420

ggtcctggcg tcctgccctg cgcgatggtc gatggatgcc ccatgcgcgt gtaaccgccc      480

agccgtcgcc atccgaccag gtgggcagac gtacgtacgg tggcacgccc acggcccatc      540

ggccatcgcg atcgcgttcg tatcgtgtcc tcaataacga aagcgccaac ggaaggcgct      600

gtcgtcgtca gttcaccgcg cgccggcgcc ctgtgtcctc gtccctctcg acttctcgac      660

cagtaagaac tctcgcgagc tgcggagctg ctggcgatgg ccggccggtg ggatccgacg      720

atttaaatct taagcctagg ataacttcgt atagcataca ttatacgaag ttatggcgcc      780

gctagcctgc agtgcagcgt gacccggtcg tgcccctctc tagagataat gagcattgca      840

tgtctaagtt ataaaaaatt accacatatt ttttttgtca cacttgtttg aagtgcagtt      900

tatctatctt tatacatata tttaaacttt actctacgaa taatataatc tatagtacta      960

caataatatc agtgttttag agaatcatat aaatgaacag ttagacatgg tctaaaggac     1020

aattgagtat tttgacaaca ggactctaca gttttatctt tttagtgtgc atgtgttctc     1080

cttttttttt gcaaatagct tcacctatat aatacttcat ccattttatt agtacatcca     1140

tttagggttt agggttaatg gtttttatag actaattttt ttagtacatc tattttattc     1200

tattttagcc tctaaattaa gaaaactaaa actctatttt agttttttta tttaataatt     1260

tagatataaa atagaataaa ataaagtgac taaaaattaa acaaataccc tttaagaaat     1320

taaaaaaact aaggaaacat ttttcttgtt tcgagtagat aatgccagcc tgttaaacgc     1380

cgtcgacgag tctaacggac accaaccagc gaaccagcag cgtcgcgtcg ggccaagcga     1440

agcagacggc acggcatctc tgtcgctgcc tctggacccc tctcgagagt tccgctccac     1500

cgttggactt gctccgctgt cggcatccag aaattgcgtg gcggagcggc agacgtgagc     1560

cggcacggca ggcggcctcc tcctcctctc acggcaccgg cagctacggg ggattccttt     1620

cccaccgctc cttcgctttc ccttcctcgc ccgccgtaat aaatagacac cccctccaca     1680

ccctctttcc ccaacctcgt gttgttcgga gcgcacacac acacaaccag atctccccca     1740

aatccacccg tcggcacctc cgcttcaagg tacgccgctc gtcctccccc ccccccctct     1800

ctaccttctc tagatcggcg ttccggtcca tgcatggtta gggcccggta gttctacttc     1860

tgttcatgtt tgtgttagat ccgtgtttgt gttagatccg tgctgctagc gttcgtacac     1920

ggatgcgacc tgtacgtcag acacgttctg attgctaact tgccagtgtt tctctttggg     1980

gaatcctggg atggctctag ccgttccgca gacgggatcg atttcatgat tttttttgtt     2040

tcgttgcata gggtttggtt tgcccttttc ctttatttca atatatgccg tgcacttgtt     2100

tgtcgggtca tcttttcatg cttttttttg tcttggttgt gatgatgtgg tctggttggg     2160

cggtcgttct agatcggagt agaattctgt ttcaaactac ctggtggatt tattaatttt     2220

ggatctgtat gtgtgtgcca tacatattca tagttacgaa ttgaagatga tggatggaaa     2280

tatcgatcta ggataggtat acatgttgat gcgggtttta ctgatgcata tacagagatg     2340

ctttttgttc gcttggttgt gatgatgtgg tgtggttggg cggtcgttca ttcgttctag     2400

atcggagtag aatactgttt caaactacct ggtgtattta ttaattttgg aactgtatgt     2460

gtgtgtcata catcttcata gttacgagtt taagatggat ggaaatatcg atctaggata     2520

ggtatacatg ttgatgtggg ttttactgat gcatatacat gatggcatat gcagcatcta     2580

ttcatatgct ctaaccttga gtacctatct attataataa acaagtatgt tttataatta     2640

ttttgatctt gatatacttg gatgatggca tatgcagcag ctatatgtgg atttttttag     2700

ccctgccttc atacgctatt tatttgcttg gtactgtttc ttttgtcgat gctcaccctg     2760

ttgtttggtg ttacttctgc aggtcgactc tagaggatca attcgctagc gaagttccta     2820

ttccgaagtt cctattctct agaaagtata ggaacttcag atccaccggg atccccgatc     2880

atgcaaaaac tcattaactc agtgcaaaac tatgcctggg gcagcaaaac ggcgttgact     2940

gaactttatg gtatggaaaa tccgtccagc cagccgatgg ccgagctgtg gatgggcgca     3000

catccgaaaa gcagttcacg agtgcagaat gccgccggag atatcgtttc actgcgtgat     3060

gtgattgaga gtgataaatc gactctgctc ggagaggccg ttgccaaacg ctttggcgaa     3120

ctgcctttcc tgttcaaagt attatgcgca gcacagccac tctccattca ggttcatcca     3180

aacaaacaca attctgaaat cggttttgcc aaagaaaatg ccgcaggtat cccgatggat     3240

gccgccgagc gtaactataa agatcctaac cacaagccgg agctggtttt tgcgctgacg     3300

cctttccttg cgatgaacgc gtttcgtgaa ttttccgaga ttgtctccct actccagccg     3360

gtcgcaggtg cacatccggc gattgctcac tttttacaac agcctgatgc cgaacgttta     3420

agcgaactgt tcgccagcct gttgaatatg cagggtgaag aaaaatcccg cgcgctggcg     3480

attttaaaat cggccctcga tagccagcag ggtgaaccgt ggcaaacgat tcgtttaatt     3540

tctgaatttt acccggaaga cagcggtctg ttctccccgc tattgctgaa tgtggtgaaa     3600

ttgaaccctg gcgaagcgat gttcctgttc gctgaaacac cgcacgctta cctgcaaggc     3660

gtggcgctgg aagtgatggc aaactccgat aacgtgctgc gtgcgggtct gacgcctaaa     3720

tacattgata ttccggaact ggttgccaat gtgaaattcg aagccaaacc ggctaaccag     3780

ttgttgaccc agccggtgaa acaaggtgca gaactggact tcccgattcc agtggatgat     3840

tttgccttct cgctgcatga ccttagtgat aaagaaacca ccattagcca gcagagtgcc     3900

gccattttgt tctgcgtcga aggcgatgca acgttgtgga aaggttctca gcagttacag     3960

cttaaaccgg gtgaatcagc gtttattgcc gccaacgaat caccggtgac tgtcaaaggc     4020

cacggccgtt tagcgcgtgt ttacaacaag ctgtaagagc ttactgaaaa aattaacatc     4080

tcttgctaag ctgggggtgg aacctagact tgtccatctt ctggattggc caacttaatt     4140

aatgtatgaa ataaaaggat gcacacatag tgacatgcta atcactataa tgtgggcatc     4200

aaagttgtgt gttatgtgta attactagtt atctgaataa aagagaaaga gatcatccat     4260

atttcttatc ctaaatgaat gtcacgtgtc tttataattc tttgatgaac cagatgcatt     4320

tcattaacca aatccatata catataaata ttaatcatat ataattaata tcaattgggt     4380

tagcaaaaca aatctagtct aggtgtgttt tgcgaatgcg gccctagcgt atacgaagtt     4440

cctattccga agttcctatt ctccagaaag tataggaact tctgtacacc tgagctgatt     4500

ccgatgactt cgtaggttcc tagctcaagc cgctcgtgtc caagcgtcac ttacgattag     4560

ctaatgatta cggcatctag gaccgactag ctaactaact agtaccgagg ccggccccgc     4620

gggagctctg cgtgcaacct cgaggccgca aacagcctgg tgacagacga agccagcaag     4680

cacgtacgta cgcacgtctc tgctggtctg gatgtgtatg gatatggacg tctcacgtct     4740

ggacgtcgtc gtcgccgttg tattgtatca tgccaaccac ttccgtaccg taccccctcg     4800

cgtgccaaca tgaccaccgc cggtacgtct ccatcgtcgg ccgtcggcgt ctcaggcagc     4860

tctcaattaa gcggacgtgt tttggtaatc tggtggaacg ccgcgcgcac tgagggtttg     4920

ggggccccgg cggacgagcg agcgagagac ggtgcatgca tgccaaatgg caacgagggc     4980

ccgcccgccc atccaataac caacccagac gtagcgcaac caacgtacga gtcctgtgct     5040

ggcgcgtacg actaccacgc tagctgccgc gacatgcgaa ctacggtcca ccaggcacca     5100

gccatgacaa tatatactgt atatatattt ttcttcttct ttttgtttcc gctctctcaa     5160

gttcctgctc tgctcctgcc tgtccgcggt gccgatcggc gagagagcat gcatggacat     5220

ggaccacgcg agatccagga accggcacgg gcccatgcgt ggcaggcggc cgtttcgtca     5280

ggttccccga aatgccccaa ctgcgcggct gcaggatggc tcatggctgg ctgcctagct     5340

ggcccgtgac accgatcgat cggtaacgac gacgcacgca cctgaagcac aggaaggagc     5400

ctccctctcg catgcacgtt agtact                                          5426


<210>  259
<211>  5152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-1 donor

<400>  259
ggtaccaaat agtaaacggg aggggaggtc gctagtagta aacgctaggt agctaggata       60

atccgtctcg tgttggacgg aaggttttgg acgcatctgc gtgcacagcc cgctgataca      120

gatctgatcg actagctagc tagatgccga ggccccagag caaggcccgg atactcctgc      180

acagtccctg agatttcagc acagcaggtg ctgttgcatc aatatataaa tccctgcttt      240

attaatttaa tctctgtgca tgtatccata catcgtcagc ggctcagcgc tatcacactg      300

cagtgcacgc agctagttga gcgcctgggt cagtatatat atagctagta gggacaaagg      360

ggggcactgt acgttggttt ggtttggcac gcacgcgatc gagagtggtg gaatggactg      420

cagatcatcg atcgctgcac tgtacgcacg cgcaccggac tgcatttgca tgcccctgaa      480

ggaggaaagg ggaaggaaag aaaagaaata ggagaaagaa gaagaagcag agaaatacgt      540

cacagtccaa gaagagtgag ccgccctagc tagcttcaac cctgacgaac ccggcagcca      600

cacttccggc catgtatgca tgcatgcatg gcttagcttc agatgtccaa tcgaatccat      660

caagacctgg ccggttttcc atggccgcct cgccttcgct agtggtacca tttaaatctt      720

aagcctagga taacttcgta tagcatacat tatacgaagt tatggcgccg ctagcctgca      780

gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta      840

taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      900

atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      960

gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt     1020

ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg     1080

caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta     1140

gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct     1200

ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa     1260

tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta     1320

aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt     1380

ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca     1440

cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg     1500

ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag     1560

gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc     1620

ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctttccc     1680

caacctcgtg ttgttcggag cgcacacaca cacaaccaga tctcccccaa atccacccgt     1740

cggcacctcc gcttcaaggt acgccgctcg tcctcccccc cccccctctc taccttctct     1800

agatcggcgt tccggtccat gcatggttag ggcccggtag ttctacttct gttcatgttt     1860

gtgttagatc cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct     1920

gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg aatcctggga     1980

tggctctagc cgttccgcag acgggatcga tttcatgatt ttttttgttt cgttgcatag     2040

ggtttggttt gcccttttcc tttatttcaa tatatgccgt gcacttgttt gtcgggtcat     2100

cttttcatgc ttttttttgt cttggttgtg atgatgtggt ctggttgggc ggtcgttcta     2160

gatcggagta gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg     2220

tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat atcgatctag     2280

gataggtata catgttgatg cgggttttac tgatgcatat acagagatgc tttttgttcg     2340

cttggttgtg atgatgtggt gtggttgggc ggtcgttcat tcgttctaga tcggagtaga     2400

atactgtttc aaactacctg gtgtatttat taattttgga actgtatgtg tgtgtcatac     2460

atcttcatag ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt     2520

tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat tcatatgctc     2580

taaccttgag tacctatcta ttataataaa caagtatgtt ttataattat tttgatcttg     2640

atatacttgg atgatggcat atgcagcagc tatatgtgga tttttttagc cctgccttca     2700

tacgctattt atttgcttgg tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt     2760

tacttctgca ggtcgactct agaggatcaa ttcgctagcg aagttcctat tccgaagttc     2820

ctattctcta gaaagtatag gaacttcaga tccaccggga tccccgatca tgcaaaaact     2880

cattaactca gtgcaaaact atgcctgggg cagcaaaacg gcgttgactg aactttatgg     2940

tatggaaaat ccgtccagcc agccgatggc cgagctgtgg atgggcgcac atccgaaaag     3000

cagttcacga gtgcagaatg ccgccggaga tatcgtttca ctgcgtgatg tgattgagag     3060

tgataaatcg actctgctcg gagaggccgt tgccaaacgc tttggcgaac tgcctttcct     3120

gttcaaagta ttatgcgcag cacagccact ctccattcag gttcatccaa acaaacacaa     3180

ttctgaaatc ggttttgcca aagaaaatgc cgcaggtatc ccgatggatg ccgccgagcg     3240

taactataaa gatcctaacc acaagccgga gctggttttt gcgctgacgc ctttccttgc     3300

gatgaacgcg tttcgtgaat tttccgagat tgtctcccta ctccagccgg tcgcaggtgc     3360

acatccggcg attgctcact ttttacaaca gcctgatgcc gaacgtttaa gcgaactgtt     3420

cgccagcctg ttgaatatgc agggtgaaga aaaatcccgc gcgctggcga ttttaaaatc     3480

ggccctcgat agccagcagg gtgaaccgtg gcaaacgatt cgtttaattt ctgaatttta     3540

cccggaagac agcggtctgt tctccccgct attgctgaat gtggtgaaat tgaaccctgg     3600

cgaagcgatg ttcctgttcg ctgaaacacc gcacgcttac ctgcaaggcg tggcgctgga     3660

agtgatggca aactccgata acgtgctgcg tgcgggtctg acgcctaaat acattgatat     3720

tccggaactg gttgccaatg tgaaattcga agccaaaccg gctaaccagt tgttgaccca     3780

gccggtgaaa caaggtgcag aactggactt cccgattcca gtggatgatt ttgccttctc     3840

gctgcatgac cttagtgata aagaaaccac cattagccag cagagtgccg ccattttgtt     3900

ctgcgtcgaa ggcgatgcaa cgttgtggaa aggttctcag cagttacagc ttaaaccggg     3960

tgaatcagcg tttattgccg ccaacgaatc accggtgact gtcaaaggcc acggccgttt     4020

agcgcgtgtt tacaacaagc tgtaagagct tactgaaaaa attaacatct cttgctaagc     4080

tgggggtgga acctagactt gtccatcttc tggattggcc aacttaatta atgtatgaaa     4140

taaaaggatg cacacatagt gacatgctaa tcactataat gtgggcatca aagttgtgtg     4200

ttatgtgtaa ttactagtta tctgaataaa agagaaagag atcatccata tttcttatcc     4260

taaatgaatg tcacgtgtct ttataattct ttgatgaacc agatgcattt cattaaccaa     4320

atccatatac atataaatat taatcatata taattaatat caattgggtt agcaaaacaa     4380

atctagtcta ggtgtgtttt gcgaatgcgg ccctagcgta tacgaagttc ctattccgaa     4440

gttcctattc tccagaaagt ataggaactt ctgtacacct gagctgattc cgatgacttc     4500

gtaggttcct agctcaagcc gctcgtgtcc aagcgtcact tacgattagc taatgattac     4560

ggcatctagg accgactagc taactaacta gtaccgaggc cggccccgcg ggagctcggc     4620

gcgcctaagg gccaagtact tgctgtccct gtatctccaa cacgagcctt gattcctgcc     4680

ggccggtgat ggcaatggcc gctagtagtc tccgctagct agggagcggc gatccgacgc     4740

gacgccacca tgtgtctaga aaagaagttt cttgctttgc atgcagactt attagcgcgg     4800

tcgacacctg tggggacccc gtgtcttgag acaatgagac tgcctgtccg cccaagacac     4860

tacttgtagc catgaagcca tcgactcctc tccttgctct ccagtaatcc agtggatgga     4920

tccatcatcg atagtttagt ttatcagtct tcttgaggcc ggtgtccccc atgcataatg     4980

atgacagaaa gcctgggcca ggtaaaagcc aaaaagtttg accctctagg tactggggcc     5040

agccctggcg tttgaacaaa aaaaaaatct gagcgtgtcg ccccggcctg ttttcgaact     5100

cctaaacgac gtcgcaactt tttttataca cacactaccg gtacatggct tt             5152


<210>  260
<211>  5146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-3 donor

<400>  260
aaatagtaaa cgggagggga ggtcgctagt agtaaacgct aggtagctag gataatccgt       60

ctcgtgttgg acggaaggtt ttggacgcat ctgcgtgcac agcccgctga tacagatctg      120

atcgactagc tagctagatg ccgaggcccc agagcaaggc ccggatactc ctgcacagtc      180

cctgagattt cagcacagca ggtgctgttg catcaatata taaatccctg ctttattaat      240

ttaatctctg tgcatgtatc catacatcgt cagcggctca gcgctatcac actgcagtgc      300

acgcagctag ttgagcgcct gggtcagtat atatatagct agtagggaca aaggggggca      360

ctgtacgttg gtttggtttg gcacgcacgc gatcgagagt ggtggaatgg actgcagatc      420

atcgatcgct gcactgtacg cacgcgcacc ggactgcatt tgcatgcccc tgaaggagga      480

aaggggaagg aaagaaaaga aataggagaa agaagaagaa gcagagaaat acgtcacagt      540

ccaagaagag tgagccgccc tagctagctt caaccctgac gaacccggca gccacacttc      600

cggccatgta tgcatgcatg catggcttag cttcagatgt ccaatcgaat ccatcaagac      660

ctggccggtt ttccatggcc gcctcgcctt cgctagttaa gggccaagta cttgctgtcc      720

ctgtggtacc atttaaatct taagcctagg ataacttcgt atagcataca ttatacgaag      780

ttatggcgcc gctagcctgc agtgcagcgt gacccggtcg tgcccctctc tagagataat      840

gagcattgca tgtctaagtt ataaaaaatt accacatatt ttttttgtca cacttgtttg      900

aagtgcagtt tatctatctt tatacatata tttaaacttt actctacgaa taatataatc      960

tatagtacta caataatatc agtgttttag agaatcatat aaatgaacag ttagacatgg     1020

tctaaaggac aattgagtat tttgacaaca ggactctaca gttttatctt tttagtgtgc     1080

atgtgttctc cttttttttt gcaaatagct tcacctatat aatacttcat ccattttatt     1140

agtacatcca tttagggttt agggttaatg gtttttatag actaattttt ttagtacatc     1200

tattttattc tattttagcc tctaaattaa gaaaactaaa actctatttt agttttttta     1260

tttaataatt tagatataaa atagaataaa ataaagtgac taaaaattaa acaaataccc     1320

tttaagaaat taaaaaaact aaggaaacat ttttcttgtt tcgagtagat aatgccagcc     1380

tgttaaacgc cgtcgacgag tctaacggac accaaccagc gaaccagcag cgtcgcgtcg     1440

ggccaagcga agcagacggc acggcatctc tgtcgctgcc tctggacccc tctcgagagt     1500

tccgctccac cgttggactt gctccgctgt cggcatccag aaattgcgtg gcggagcggc     1560

agacgtgagc cggcacggca ggcggcctcc tcctcctctc acggcaccgg cagctacggg     1620

ggattccttt cccaccgctc cttcgctttc ccttcctcgc ccgccgtaat aaatagacac     1680

cccctccaca ccctctttcc ccaacctcgt gttgttcgga gcgcacacac acacaaccag     1740

atctccccca aatccacccg tcggcacctc cgcttcaagg tacgccgctc gtcctccccc     1800

ccccccctct ctaccttctc tagatcggcg ttccggtcca tgcatggtta gggcccggta     1860

gttctacttc tgttcatgtt tgtgttagat ccgtgtttgt gttagatccg tgctgctagc     1920

gttcgtacac ggatgcgacc tgtacgtcag acacgttctg attgctaact tgccagtgtt     1980

tctctttggg gaatcctggg atggctctag ccgttccgca gacgggatcg atttcatgat     2040

tttttttgtt tcgttgcata gggtttggtt tgcccttttc ctttatttca atatatgccg     2100

tgcacttgtt tgtcgggtca tcttttcatg cttttttttg tcttggttgt gatgatgtgg     2160

tctggttggg cggtcgttct agatcggagt agaattctgt ttcaaactac ctggtggatt     2220

tattaatttt ggatctgtat gtgtgtgcca tacatattca tagttacgaa ttgaagatga     2280

tggatggaaa tatcgatcta ggataggtat acatgttgat gcgggtttta ctgatgcata     2340

tacagagatg ctttttgttc gcttggttgt gatgatgtgg tgtggttggg cggtcgttca     2400

ttcgttctag atcggagtag aatactgttt caaactacct ggtgtattta ttaattttgg     2460

aactgtatgt gtgtgtcata catcttcata gttacgagtt taagatggat ggaaatatcg     2520

atctaggata ggtatacatg ttgatgtggg ttttactgat gcatatacat gatggcatat     2580

gcagcatcta ttcatatgct ctaaccttga gtacctatct attataataa acaagtatgt     2640

tttataatta ttttgatctt gatatacttg gatgatggca tatgcagcag ctatatgtgg     2700

atttttttag ccctgccttc atacgctatt tatttgcttg gtactgtttc ttttgtcgat     2760

gctcaccctg ttgtttggtg ttacttctgc aggtcgactc tagaggatca attcgctagc     2820

gaagttccta ttccgaagtt cctattctct agaaagtata ggaacttcag atccaccggg     2880

atccccgatc atgcaaaaac tcattaactc agtgcaaaac tatgcctggg gcagcaaaac     2940

ggcgttgact gaactttatg gtatggaaaa tccgtccagc cagccgatgg ccgagctgtg     3000

gatgggcgca catccgaaaa gcagttcacg agtgcagaat gccgccggag atatcgtttc     3060

actgcgtgat gtgattgaga gtgataaatc gactctgctc ggagaggccg ttgccaaacg     3120

ctttggcgaa ctgcctttcc tgttcaaagt attatgcgca gcacagccac tctccattca     3180

ggttcatcca aacaaacaca attctgaaat cggttttgcc aaagaaaatg ccgcaggtat     3240

cccgatggat gccgccgagc gtaactataa agatcctaac cacaagccgg agctggtttt     3300

tgcgctgacg cctttccttg cgatgaacgc gtttcgtgaa ttttccgaga ttgtctccct     3360

actccagccg gtcgcaggtg cacatccggc gattgctcac tttttacaac agcctgatgc     3420

cgaacgttta agcgaactgt tcgccagcct gttgaatatg cagggtgaag aaaaatcccg     3480

cgcgctggcg attttaaaat cggccctcga tagccagcag ggtgaaccgt ggcaaacgat     3540

tcgtttaatt tctgaatttt acccggaaga cagcggtctg ttctccccgc tattgctgaa     3600

tgtggtgaaa ttgaaccctg gcgaagcgat gttcctgttc gctgaaacac cgcacgctta     3660

cctgcaaggc gtggcgctgg aagtgatggc aaactccgat aacgtgctgc gtgcgggtct     3720

gacgcctaaa tacattgata ttccggaact ggttgccaat gtgaaattcg aagccaaacc     3780

ggctaaccag ttgttgaccc agccggtgaa acaaggtgca gaactggact tcccgattcc     3840

agtggatgat tttgccttct cgctgcatga ccttagtgat aaagaaacca ccattagcca     3900

gcagagtgcc gccattttgt tctgcgtcga aggcgatgca acgttgtgga aaggttctca     3960

gcagttacag cttaaaccgg gtgaatcagc gtttattgcc gccaacgaat caccggtgac     4020

tgtcaaaggc cacggccgtt tagcgcgtgt ttacaacaag ctgtaagagc ttactgaaaa     4080

aattaacatc tcttgctaag ctgggggtgg aacctagact tgtccatctt ctggattggc     4140

caacttaatt aatgtatgaa ataaaaggat gcacacatag tgacatgcta atcactataa     4200

tgtgggcatc aaagttgtgt gttatgtgta attactagtt atctgaataa aagagaaaga     4260

gatcatccat atttcttatc ctaaatgaat gtcacgtgtc tttataattc tttgatgaac     4320

cagatgcatt tcattaacca aatccatata catataaata ttaatcatat ataattaata     4380

tcaattgggt tagcaaaaca aatctagtct aggtgtgttt tgcgaatgcg gccctagcgt     4440

atacgaagtt cctattccga agttcctatt ctccagaaag tataggaact tctgtacacc     4500

tgagctgatt ccgatgactt cgtaggttcc tagctcaagc cgctcgtgtc caagcgtcac     4560

ttacgattag ctaatgatta cggcatctag gaccgactag ctaactaact agtaccgagg     4620

ccggccccgc gggagctcgg cgcgccatct ccaacacgag ccttgattcc tgccggccgg     4680

tgatggcaat ggccgctagt agtctccgct agctagggag cggcgatccg acgcgacgcc     4740

accatgtgtc tagaaaagaa gtttcttgct ttgcatgcag acttattagc gcggtcgaca     4800

cctgtgggga ccccgtgtct tgagacaatg agactgcctg tccgcccaag acactacttg     4860

tagccatgaa gccatcgact cctctccttg ctctccagta atccagtgga tggatccatc     4920

atcgatagtt tagtttatca gtcttcttga ggccggtgtc ccccatgcat aatgatgaca     4980

gaaagcctgg gccaggtaaa agccaaaaag tttgaccctc taggtactgg ggccagccct     5040

ggcgtttgaa caaaaaaaaa atctgagcgt gtcgccccgg cctgttttcg aactcctaaa     5100

cgacgtcgca acttttttta tacacacact accggtacat ggcttt                    5146


<210>  261
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ubir primer from donor

<400>  261
ccatgtctaa ctgttcattt atatgattct ct                                     32


<210>  262
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  psbf primer from dono

<400>  262
gctcgtgtcc aagcgtcact tacgattagc t                                      31


<210>  263
<211>  27
<212>  DNA
<213>  Artificial Sequences

<220>
<223>  MHP14 14-1HR1f primer

<400>  263
ctcacatgag gctcttcttt gcttgct                                           27


<210>  264
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14 14-1HR2r primer

<400>  264
aggatcctat tccccaattt gtagat                                            26


<210>  265
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-8 8HR1f primer

<400>  265
cagtccgtgg attgaagcca t                                                 21


<210>  266
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-8 8HR2r primer

<400>  266
ctctgtctcc gagacgtgct ta                                                22


<210>  267
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-9 9HR1f primer

<400>  267
ggagcaaatg ttttaggtat gaaatg                                            26


<210>  268
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-9  9HR2r primer

<400>  268
cggattctaa agatcatacg taaatgaa                                          28


<210>  269
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-10  10HR1f primer

<400>  269
tggcttgtct atgcgcatct c                                                 21


<210>  270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHR1-10  10HR2r primer

<400>  270
ccagacccaa acagcaggtt                                                   20


<210>  271
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas-1 probe

<400>  271
cagattcacg tcagattt                                                     18


<210>  272
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14cas-1 forward primer

<400>  272
catagtggtg tatgaaagga agcactt                                           27


<210>  273
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14cas-1 reverse primer

<400>  273
cattttggat tgtaatatgt gtacctcata                                        30


<210>  274
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas-3 probe

<400>  274
caccactatg tcgcttc                                                      17


<210>  275
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas-3 forward primer

<400>  275
cggatgcacg aaaattgtag ga                                                22


<210>  276
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHP14Cas-3 reverse primer

<400>  276
ctgacgtgaa tctgtttgga attg                                              24


<210>  277
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-1 probe

<400>  277
tacgtaacgt gcagtact                                                     18


<210>  278
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-1 forward primer

<400>  278
acggacggac catacgttat g                                                 21


<210>  279
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-1 reverse primer

<400>  279
tcagctggtg gagtatatta gttcgt                                            26


<210>  280
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-2 probe

<400>  280
ccagctgatc actgatga                                                     18


<210>  281
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-2 forward primer

<400>  281
acggacggac catacgttat g                                                 21


<210>  282
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS8Cas-2 reverse primer

<400>  282
cgcacatgtt ataaattaca atgcat                                            26


<210>  283
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-2 probe

<400>  283
ctgtttgcgg cctc                                                         14


<210>  284
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-2 forward primer

<400>  284
ctgcggagct gctggcgat                                                    19


<210>  285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-2 reverse primer

<400>  285
cttgctggct tcgtctgtca                                                   20


<210>  286
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-3 probe

<400>  286
ccgacgtgcg tgcaa                                                        15


<210>  287
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-3 forward primer

<400>  287
ctgcggagct gctggcgat                                                    19


<210>  288
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS9Cas-3 reverse primer

<400>  288
cttgctggct tcgtctgtca                                                   20


<210>  289
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-1 probe

<400>  289
tcgccttcgc tagttaa                                                      17


<210>  290
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-1 forward primer

<400>  290
aagacctggc cggttttcca                                                   20


<210>  291
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-1 reverse primer

<400>  291
tagcggccat tgccatca                                                     18


<210>  292
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-3 probe

<400>  292
ctgtatctcc aacacgagc                                                    19


<210>  293
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-3 forward primer

<400>  293
aagacctggc cggttttcca                                                   20


<210>  294
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TS10Cas-3 reverse primer

<400>  294
tagcggccat tgccatca                                                     18


<210>  295
<211>  472
<212>  DNA
<213>  Glycine max


<220>
<221>  GM-U6-9.1 promoter
<222>  (1)..(472)

<400>  295
cccgggttaa gagaattgta agtgtgcttt tatatattta aaattaatat attttgaaat       60

gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt aataaagata      120

aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg ctcttaaatt      180

tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag catgaaaaaa      240

gtcactaaag agctatataa ctcatgcagc tagaaatgaa gtgaagggaa tccagtttgt      300

tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag caaaatggga      360

atgcgaggta tcttcctttc gttaggggag caccagatgc atagttagtc ccacattgat      420

gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc tt              472


<210>  296
<211>  5958
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1A2-CAS9

<400>  296
gggtttactt attttgtggg tatctatact tttattagat ttttaatcag gctcctgatt       60

tctttttatt tcgattgaat tcctgaactt gtattattca gtagatcgaa taaattataa      120

aaagataaaa tcataaaata atattttatc ctatcaatca tattaaagca atgaatatgt      180

aaaattaatc ttatctttat tttaaaaaat catataggtt tagtattttt ttaaaaataa      240

agataggatt agttttacta ttcactgctt attactttta aaaaaatcat aaaggtttag      300

tattttttta aaataaatat aggaatagtt ttactattca ctgctttaat agaaaaatag      360

tttaaaattt aagatagttt taatcccagc atttgccacg tttgaacgtg agccgaaacg      420

atgtcgttac attatcttaa cctagctgaa acgatgtcgt cataatatcg ccaaatgcca      480

actggactac gtcgaaccca caaatcccac aaagcgcgtg aaatcaaatc gctcaaacca      540

caaaaaagaa caacgcgttt gttacacgct caatcccacg cgagtagagc acagtaacct      600

tcaaataagc gaatggggca taatcagaaa tccgaaataa acctaggggc attatcggaa      660

atgaaaagta gctcactcaa tataaaaatc taggaaccct agttttcgtt atcactctgt      720

gctccctcgc tctatttctc agtctctgtg tttgcggctg aggattccga acgagtgacc      780

ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc tcttcgattc gatctatgcc      840

tgtctcttat ttacgatgat gtttcttcgg ttatgttttt ttatttatgc tttatgctgt      900

tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca gttttttagg attcttttgg      960

tttttgaatc gattaatcgg aagagatttt cgagttattt ggtgtgttgg aggtgaatct     1020

tttttttgag gtcatagatc tgttgtattt gtgttataaa catgcgactt tgtatgattt     1080

tttacgaggt tatgatgttc tggttgtttt attatgaatc tgttgagaca gaaccatgat     1140

ttttgttgat gttcgtttac actattaaag gtttgtttta acaggattaa aagtttttta     1200

agcatgttga aggagtcttg tagatatgta accgtcgata gtttttttgt gggtttgttc     1260

acatgttatc aagcttaatc ttttactatg tatgcgacca tatctggatc cagcaaaggc     1320

gattttttaa ttccttgtga aacttttgta atatgaagtt gaaattttgt tattggtaaa     1380

ctataaatgt gtgaagttgg agtatacctt taccttctta tttggctttg tgatagttta     1440

atttatatgt attttgagtt ctgacttgta tttctttgaa ttgattctag tttaagtaat     1500

ccatggacaa aaagtactca atagggctcg acatagggac taactccgtt ggatgggccg     1560

tcatcaccga cgagtacaag gtgccctcca agaagttcaa ggtgttggga aacaccgaca     1620

ggcacagcat aaagaagaat ttgatcggtg ccctcctctt cgactccgga gagaccgctg     1680

aggctaccag gctcaagagg accgctagaa ggcgctacac cagaaggaag aacagaatct     1740

gctacctgca ggagatcttc tccaacgaga tggccaaggt ggacgactcc ttcttccacc     1800

gccttgagga atcattcctg gtggaggagg ataaaaagca cgagagacac ccaatcttcg     1860

ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc taccatctac cacctgagga     1920

agaagctggt cgactctacc gacaaggctg acttgcgctt gatttacctg gctctcgctc     1980

acatgataaa gttccgcgga cacttcctca ttgagggaga cctgaaccca gacaactccg     2040

acgtggacaa gctcttcatc cagctcgttc agacctacaa ccagcttttc gaggagaacc     2100

caatcaacgc cagtggagtt gacgccaagg ctatcctctc tgctcgtctg tcaaagtcca     2160

ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa gaagaacgga ctgttcggaa     2220

acttgatcgc tctctccctg ggattgactc ccaacttcaa gtccaacttc gacctcgccg     2280

aggacgctaa gttgcagttg tctaaagaca cctacgacga tgacctcgac aacttgctgg     2340

cccagatagg cgaccaatac gccgatctct tcctcgccgc taagaacttg tccgacgcaa     2400

tcctgctgtc cgacatcctg agagtcaaca ctgagattac caaagctcct ctgtctgctt     2460

ccatgattaa gcgctacgac gagcaccacc aagatctgac cctgctcaag gccctggtga     2520

gacagcagct gcccgagaag tacaaggaga tctttttcga ccagtccaag aacggctacg     2580

ccggatacat tgacggaggc gcctcccagg aagagttcta caagttcatc aagcccatcc     2640

ttgagaagat ggacggtacc gaggagctgt tggtgaagtt gaacagagag gacctgttga     2700

ggaagcagag aaccttcgac aacggaagca tccctcacca aatccacctg ggagagctcc     2760

acgccatctt gaggaggcag gaggatttct atcccttcct gaaggacaac cgcgagaaga     2820

ttgagaagat cttgaccttc agaattcctt actacgtcgg gccactcgcc agaggaaact     2880

ctaggttcgc ctggatgacc cgcaaatctg aagagaccat tactccctgg aacttcgagg     2940

aagtcgtgga caagggcgct tccgctcagt ctttcatcga gaggatgacc aacttcgata     3000

aaaatctgcc caacgagaag gtgctgccca agcactccct gttgtacgag tatttcacag     3060

tgtacaacga gctcaccaag gtgaagtacg tcacagaggg aatgaggaag cctgccttct     3120

tgtccggaga gcagaagaag gccatcgtcg acctgctctt caagaccaac aggaaggtga     3180

ctgtcaagca gctgaaggag gactacttca agaagatcga gtgcttcgac tccgtcgaga     3240

tctctggtgt cgaggacagg ttcaacgcct cccttgggac ttaccacgat ctgctcaaga     3300

ttattaaaga caaggacttc ctggacaacg aggagaacga ggacatcctt gaggacatcg     3360

tgctcaccct gaccttgttc gaagacaggg aaatgatcga agagaggctc aagacctacg     3420

cccacctctt cgacgacaag gtgatgaaac agctgaagag acgcagatat accggctggg     3480

gaaggctctc ccgcaaattg atcaacggga tcagggacaa gcagtcaggg aagactatac     3540

tcgacttcct gaagtccgac ggattcgcca acaggaactt catgcagctc attcacgacg     3600

actccttgac cttcaaggag gacatccaga aggctcaggt gtctggacag ggtgactcct     3660

tgcatgagca cattgctaac ttggccggct ctcccgctat taagaagggc attttgcaga     3720

ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg ccacaagcca gagaacatcg     3780

ttattgagat ggctcgcgag aaccaaacta cccagaaagg gcagaagaat tcccgcgaga     3840

ggatgaagcg cattgaggag ggcataaaag agcttggctc tcagatcctc aaggagcacc     3900

ccgtcgagaa cactcagctg cagaacgaga agctgtacct gtactacctc caaaacggaa     3960

gggacatgta cgtggaccag gagctggaca tcaacaggtt gtccgactac gacgtcgacc     4020

acatcgtgcc tcagtccttc ctgaaggatg actccatcga caataaagtg ctgacacgct     4080

ccgataaaaa tagaggcaag tccgacaacg tcccctccga ggaggtcgtg aagaagatga     4140

aaaactactg gagacagctc ttgaacgcca agctcatcac ccagcgtaag ttcgacaacc     4200

tgactaaggc tgagagagga ggattgtccg agctcgataa ggccggattc atcaagagac     4260

agctcgtcga aacccgccaa attaccaagc acgtggccca aattctggat tcccgcatga     4320

acaccaagta cgatgaaaat gacaagctga tccgcgaggt caaggtgatc accttgaagt     4380

ccaagctggt ctccgacttc cgcaaggact tccagttcta caaggtgagg gagatcaaca     4440

actaccacca cgcacacgac gcctacctca acgctgtcgt tggaaccgcc ctcatcaaaa     4500

aatatcctaa gctggagtct gagttcgtct acggcgacta caaggtgtac gacgtgagga     4560

agatgatcgc taagtctgag caggagatcg gcaaggccac cgccaagtac ttcttctact     4620

ccaacatcat gaacttcttc aagaccgaga tcactctcgc caacggtgag atcaggaagc     4680

gcccactgat cgagaccaac ggtgagactg gagagatcgt gtgggacaaa gggagggatt     4740

tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa catcgtcaag aagaccgaag     4800

ttcagaccgg aggattctcc aaggagtcca tcctccccaa gagaaactcc gacaagctga     4860

tcgctagaaa gaaagactgg gaccctaaga agtacggagg cttcgattct cctaccgtgg     4920

cctactctgt gctggtcgtg gccaaggtgg agaagggcaa gtccaagaag ctgaaatccg     4980

tcaaggagct cctcgggatt accatcatgg agaggagttc cttcgagaag aaccctatcg     5040

acttcctgga ggccaaggga tataaagagg tgaagaagga cctcatcatc aagctgccca     5100

agtactccct cttcgagttg gagaacggaa ggaagaggat gctggcttct gccggagagt     5160

tgcagaaggg aaatgagctc gcccttccct ccaagtacgt gaacttcctg tacctcgcct     5220

ctcactatga aaagttgaag ggctctcctg aggacaacga gcagaagcag ctcttcgtgg     5280

agcagcacaa gcactacctg gacgaaatta tcgagcagat ctctgagttc tccaagcgcg     5340

tgatattggc cgacgccaac ctcgacaagg tgctgtccgc ctacaacaag cacagggata     5400

agcccattcg cgagcaggct gaaaacatta tccacctgtt taccctcaca aacttgggag     5460

cccctgctgc cttcaagtac ttcgacacca ccattgacag gaagagatac acctccacca     5520

aggaggtgct cgacgcaaca ctcatccacc aatccatcac cggcctctat gaaacaagga     5580

ttgacttgtc ccagctggga ggcgactcta gagccgatcc caagaagaag agaaaggtgt     5640

aggttaacct agacttgtcc atcttctgga ttggccaact taattaatgt atgaaataaa     5700

aggatgcaca catagtgaca tgctaatcac tataatgtgg gcatcaaagt tgtgtgttat     5760

gtgtaattac tagttatctg aataaaagag aaagagatca tccatatttc ttatcctaaa     5820

tgaatgtcac gtgtctttat aattctttga tgaaccagat gcatttcatt aaccaaatcc     5880

atatacatat aaatattaat catatataat taatatcaat tgggttagca aaacaaatct     5940

agtctaggtg tgttttgc                                                   5958


<210>  297
<211>  573
<212>  DNA
<213>  Artificial sequence

<220>
<223>  U6-9.1-DD20CR1

<400>  297
ccgggttaag agaattgtaa gtgtgctttt atatatttaa aattaatata ttttgaaatg       60

ttaaaatata aaagaaaatt caatgtaaat taaaaataaa taaatgttta ataaagataa      120

attttaaaac ataaaagaaa atgtctaaca agaggattaa gatcctgtgc tcttaaattt      180

ttaggtgttg aaatcttagc catacaaaat atattttatt aaaaccaagc atgaaaaaag      240

tcactaaaga gctatataac tcatgcagct agaaatgaag tgaagggaat ccagtttgtt      300

ctcagtcgaa agagtgtcta tctttgttct tttctgcaac cgagttaagc aaaatgggaa      360

tgcgaggtat cttcctttcg ttaggggagc accagatgca tagttagtcc cacattgatg      420

aatataacaa gagcttcaca gaatatatag cccaggccac agtaaaagct tggaactgac      480

acacgacatg agttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      540

cttgaaaaag tggcaccgag tcggtgcttt ttt                                   573


<210>  298
<211>  6611
<212>  DNA
<213>  Artificial sequence

<220>
<223>  U6-9.1-DD20CR1+EF1A2-CAS9

<400>  298
cgcgccggta cccgggttaa gagaattgta agtgtgcttt tatatattta aaattaatat       60

attttgaaat gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt      120

aataaagata aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg      180

ctcttaaatt tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag      240

catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa gtgaagggaa      300

tccagtttgt tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag      360

caaaatggga atgcgaggta tcttcctttc gttaggggag caccagatgc atagttagtc      420

ccacattgat gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc      480

ttggaactga cacacgacat gagttttaga gctagaaata gcaagttaaa ataaggctag      540

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg ccgcaattgg      600

atcgggttta cttattttgt gggtatctat acttttatta gatttttaat caggctcctg      660

atttcttttt atttcgattg aattcctgaa cttgtattat tcagtagatc gaataaatta      720

taaaaagata aaatcataaa ataatatttt atcctatcaa tcatattaaa gcaatgaata      780

tgtaaaatta atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa      840

taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat cataaaggtt      900

tagtattttt ttaaaataaa tataggaata gttttactat tcactgcttt aatagaaaaa      960

tagtttaaaa tttaagatag ttttaatccc agcatttgcc acgtttgaac gtgagccgaa     1020

acgatgtcgt tacattatct taacctagct gaaacgatgt cgtcataata tcgccaaatg     1080

ccaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa     1140

ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag agcacagtaa     1200

ccttcaaata agcgaatggg gcataatcag aaatccgaaa taaacctagg ggcattatcg     1260

gaaatgaaaa gtagctcact caatataaaa atctaggaac cctagttttc gttatcactc     1320

tgtgctccct cgctctattt ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg     1380

accttcttcg tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat     1440

gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta tgctttatgc     1500

tgttgatgtt cggttgtttg tttcgctttg tttttgtggt tcagtttttt aggattcttt     1560

tggtttttga atcgattaat cggaagagat tttcgagtta tttggtgtgt tggaggtgaa     1620

tctttttttt gaggtcatag atctgttgta tttgtgttat aaacatgcga ctttgtatga     1680

ttttttacga ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat     1740

gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat taaaagtttt     1800

ttaagcatgt tgaaggagtc ttgtagatat gtaaccgtcg atagtttttt tgtgggtttg     1860

ttcacatgtt atcaagctta atcttttact atgtatgcga ccatatctgg atccagcaaa     1920

ggcgattttt taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt     1980

aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct ttgtgatagt     2040

ttaatttata tgtattttga gttctgactt gtatttcttt gaattgattc tagtttaagt     2100

aatccatgga caaaaagtac tcaatagggc tcgacatagg gactaactcc gttggatggg     2160

ccgtcatcac cgacgagtac aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg     2220

acaggcacag cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg     2280

ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg aagaacagaa     2340

tctgctacct gcaggagatc ttctccaacg agatggccaa ggtggacgac tccttcttcc     2400

accgccttga ggaatcattc ctggtggagg aggataaaaa gcacgagaga cacccaatct     2460

tcgggaacat cgtcgacgag gtggcctacc atgaaaagta ccctaccatc taccacctga     2520

ggaagaagct ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg     2580

ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac ccagacaact     2640

ccgacgtgga caagctcttc atccagctcg ttcagaccta caaccagctt ttcgaggaga     2700

acccaatcaa cgccagtgga gttgacgcca aggctatcct ctctgctcgt ctgtcaaagt     2760

ccaggaggct tgagaacttg attgcccagc tgcctggcga aaagaagaac ggactgttcg     2820

gaaacttgat cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg     2880

ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc gacaacttgc     2940

tggcccagat aggcgaccaa tacgccgatc tcttcctcgc cgctaagaac ttgtccgacg     3000

caatcctgct gtccgacatc ctgagagtca acactgagat taccaaagct cctctgtctg     3060

cttccatgat taagcgctac gacgagcacc accaagatct gaccctgctc aaggccctgg     3120

tgagacagca gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct     3180

acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc atcaagccca     3240

tccttgagaa gatggacggt accgaggagc tgttggtgaa gttgaacaga gaggacctgt     3300

tgaggaagca gagaaccttc gacaacggaa gcatccctca ccaaatccac ctgggagagc     3360

tccacgccat cttgaggagg caggaggatt tctatccctt cctgaaggac aaccgcgaga     3420

agattgagaa gatcttgacc ttcagaattc cttactacgt cgggccactc gccagaggaa     3480

actctaggtt cgcctggatg acccgcaaat ctgaagagac cattactccc tggaacttcg     3540

aggaagtcgt ggacaagggc gcttccgctc agtctttcat cgagaggatg accaacttcg     3600

ataaaaatct gcccaacgag aaggtgctgc ccaagcactc cctgttgtac gagtatttca     3660

cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga gggaatgagg aagcctgcct     3720

tcttgtccgg agagcagaag aaggccatcg tcgacctgct cttcaagacc aacaggaagg     3780

tgactgtcaa gcagctgaag gaggactact tcaagaagat cgagtgcttc gactccgtcg     3840

agatctctgg tgtcgaggac aggttcaacg cctcccttgg gacttaccac gatctgctca     3900

agattattaa agacaaggac ttcctggaca acgaggagaa cgaggacatc cttgaggaca     3960

tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat cgaagagagg ctcaagacct     4020

acgcccacct cttcgacgac aaggtgatga aacagctgaa gagacgcaga tataccggct     4080

ggggaaggct ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca gggaagacta     4140

tactcgactt cctgaagtcc gacggattcg ccaacaggaa cttcatgcag ctcattcacg     4200

acgactcctt gaccttcaag gaggacatcc agaaggctca ggtgtctgga cagggtgact     4260

ccttgcatga gcacattgct aacttggccg gctctcccgc tattaagaag ggcattttgc     4320

agaccgtgaa ggtcgttgac gagctcgtga aggtgatggg acgccacaag ccagagaaca     4380

tcgttattga gatggctcgc gagaaccaaa ctacccagaa agggcagaag aattcccgcg     4440

agaggatgaa gcgcattgag gagggcataa aagagcttgg ctctcagatc ctcaaggagc     4500

accccgtcga gaacactcag ctgcagaacg agaagctgta cctgtactac ctccaaaacg     4560

gaagggacat gtacgtggac caggagctgg acatcaacag gttgtccgac tacgacgtcg     4620

accacatcgt gcctcagtcc ttcctgaagg atgactccat cgacaataaa gtgctgacac     4680

gctccgataa aaatagaggc aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga     4740

tgaaaaacta ctggagacag ctcttgaacg ccaagctcat cacccagcgt aagttcgaca     4800

acctgactaa ggctgagaga ggaggattgt ccgagctcga taaggccgga ttcatcaaga     4860

gacagctcgt cgaaacccgc caaattacca agcacgtggc ccaaattctg gattcccgca     4920

tgaacaccaa gtacgatgaa aatgacaagc tgatccgcga ggtcaaggtg atcaccttga     4980

agtccaagct ggtctccgac ttccgcaagg acttccagtt ctacaaggtg agggagatca     5040

acaactacca ccacgcacac gacgcctacc tcaacgctgt cgttggaacc gccctcatca     5100

aaaaatatcc taagctggag tctgagttcg tctacggcga ctacaaggtg tacgacgtga     5160

ggaagatgat cgctaagtct gagcaggaga tcggcaaggc caccgccaag tacttcttct     5220

actccaacat catgaacttc ttcaagaccg agatcactct cgccaacggt gagatcagga     5280

agcgcccact gatcgagacc aacggtgaga ctggagagat cgtgtgggac aaagggaggg     5340

atttcgctac tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg     5400

aagttcagac cggaggattc tccaaggagt ccatcctccc caagagaaac tccgacaagc     5460

tgatcgctag aaagaaagac tgggacccta agaagtacgg aggcttcgat tctcctaccg     5520

tggcctactc tgtgctggtc gtggccaagg tggagaaggg caagtccaag aagctgaaat     5580

ccgtcaagga gctcctcggg attaccatca tggagaggag ttccttcgag aagaacccta     5640

tcgacttcct ggaggccaag ggatataaag aggtgaagaa ggacctcatc atcaagctgc     5700

ccaagtactc cctcttcgag ttggagaacg gaaggaagag gatgctggct tctgccggag     5760

agttgcagaa gggaaatgag ctcgcccttc cctccaagta cgtgaacttc ctgtacctcg     5820

cctctcacta tgaaaagttg aagggctctc ctgaggacaa cgagcagaag cagctcttcg     5880

tggagcagca caagcactac ctggacgaaa ttatcgagca gatctctgag ttctccaagc     5940

gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac aagcacaggg     6000

ataagcccat tcgcgagcag gctgaaaaca ttatccacct gtttaccctc acaaacttgg     6060

gagcccctgc tgccttcaag tacttcgaca ccaccattga caggaagaga tacacctcca     6120

ccaaggaggt gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa     6180

ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag aagagaaagg     6240

tgtaggttaa cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat     6300

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt     6360

tatgtgtaat tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct     6420

aaatgaatgt cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa     6480

tccatataca tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa     6540

tctagtctag gtgtgttttg cgaattcgat atcaagctta tcgataccgt cgaggggggg     6600

cccggtaccg g                                                          6611


<210>  299
<211>  5686
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20HR1-SAMS:HPT-DD20HR2

<400>  299
cgcgcctcta gttgaagaca cgttcatgtc ttcatcgtaa gaagacactc agtagtcttc       60

ggccagaatg gccatctgga ttcagcaggc ctagaaggcc atttaaatcc tgaggatctg      120

gtcttcctaa ggacccggga tatcgctatc aactttgtat agaaaagttg ggccgaattc      180

gagctcggta cggccagaat ccggtaagtg actagggtca cgtgacccta gtcacttaaa      240

ttcggccaga atggccatct ggattcagca ggcctagaag gcccggaccg attaaacttt      300

aattcggtcc gggttacctc gagcctagta ataattacac atctaagata tccccttctt      360

tttcaagtaa aataatatca tatgatctca ttttagtgaa acaatactat ttccctgata      420

actctcttca acattaggga cttcatctaa tcatctactt tcaaggtata actagacgta      480

tttgttcttt taaaaaaaac actagatgta ctcgtcaact caaaattcat cgttcatgca      540

ttttaattaa actttaatta gctaatgagt agaaaaagat catacgagta aaatagaaga      600

atcttcctag attttggaag aatggattgg agtgtaagtg aattgatcca ttagtggaag      660

atgctcttta caatggccaa actgttctaa ttgttagagc acatttgaga tgaaacactt      720

cagtagtgga ggtaacctac aatcctagga tctgtatcct ctatcactaa tggagcaatg      780

ggtttgagat tgacttactc ctttccttgt ctctcgtagt gcatatgcgc actttcaaag      840

gctacacaaa agccgttaac tttttgttta tttaagttac gaaagatagt tgaattagag      900

taaatggtga tattgaatta ggattttaaa taattttaaa agaatttttt taataaaaaa      960

aatattgtgt tgttggatca aaatttttaa ataacatgaa taaggaaatg gattgcaatg     1020

aggttttaaa caattatttt aacatatagg attttagaaa gacttttata atattttgtt     1080

gaagtttaga ttttaatata tttatgtttt aaaattttaa aaaaaacttc atgaatttat     1140

aatatttgaa aaagacacgt gaatatttag aaaacattta aaattacaat aataaatcat     1200

aatgagatag ggtgtattca tgtgtagacg agacaccaag tatatggttc acaagtgaat     1260

catctttttt ttttacagca caagtagatc acttgtactt atcaaaattc ggaactgaca     1320

cacactagtg gtcacctaag tgactagggt cacgtgaccc tagtcactta ttcccaaaca     1380

ctagtaacgg ccgccagtgt gctggaattc gcccttccca agctttgctc tagatcaaac     1440

tcacatccaa acataacatg gatatcttcc ttaccaatca tactaattat tttgggttaa     1500

atattaatca ttatttttaa gatattaatt aagaaattaa aagatttttt aaaaaaatgt     1560

ataaaattat attattcatg atttttcata catttgattt tgataataaa tatatttttt     1620

ttaatttctt aaaaaatgtt gcaagacact tattagacat agtcttgttc tgtttacaaa     1680

agcattcatc atttaataca ttaaaaaata tttaatacta acagtagaat cttcttgtga     1740

gtggtgtggg agtaggcaac ctggcattga aacgagagaa agagagtcag aaccagaaga     1800

caaataaaaa gtatgcaaca aacaaatcaa aatcaaaggg caaaggctgg ggttggctca     1860

attggttgct acattcaatt ttcaactcag tcaacggttg agattcactc tgacttcccc     1920

aatctaagcc gcggatgcaa acggttgaat ctaacccaca atccaatctc gttacttagg     1980

ggcttttccg tcattaactc acccctgcca cccggtttcc ctataaattg gaactcaatg     2040

ctcccctcta aactcgtatc gcttcagagt tgagaccaag acacactcgt tcatatatct     2100

ctctgctctt ctcttctctt ctacctctca aggtactttt cttctccctc taccaaatcc     2160

tagattccgt ggttcaattt cggatcttgc acttctggtt tgctttgcct tgctttttcc     2220

tcaactgggt ccatctagga tccatgtgaa actctactct ttctttaata tctgcggaat     2280

acgcgtttga ctttcagatc tagtcgaaat catttcataa ttgcctttct ttcttttagc     2340

ttatgagaaa taaaatcact ttttttttat ttcaaaataa accttgggcc ttgtgctgac     2400

tgagatgggg tttggtgatt acagaatttt agcgaatttt gtaattgtac ttgtttgtct     2460

gtagttttgt tttgttttct tgtttctcat acattcctta ggcttcaatt ttattcgagt     2520

ataggtcaca ataggaattc aaactttgag caggggaatt aatcccttcc ttcaaatcca     2580

gtttgtttgt atatatgttt aaaaaatgaa acttttgctt taaattctat tataactttt     2640

tttatggctg aaatttttgc atgtgtcttt gctctctgtt gtaaatttac tgtttaggta     2700

ctaactctag gcttgttgtg cagtttttga agtataacaa cagaagttcc tattccgaag     2760

ttcctattct ctagaaagta taggaacttc cactagtcca tgaaaaagcc tgaactcacc     2820

gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag     2880

ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc     2940

ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt     3000

gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaattcag cgagagcctg     3060

acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa     3120

ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt     3180

agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg     3240

cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac     3300

gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac     3360

tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac     3420

aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac     3480

gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc     3540

tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc     3600

cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct     3660

tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca     3720

caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat     3780

agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagtgagg tacctaaaga     3840

aggagtgcgt cgaagcagat cgttcaaaca tttggcaata aagtttctta agattgaatc     3900

ctgttgccgg tcttgcgatg attatcatat aatttctgtt gaattacgtt aagcatgtaa     3960

taattaacat gtaatgcatg acgttattta tgagatgggt ttttatgatt agagtcccgc     4020

aattatacat ttaatacgcg atagaaaaca aaatatagcg cgcaaactag gataaattat     4080

cgcgcgcggt gtcatctatg ttactagatc gatgtcgacc cgggccctag gaggccggcc     4140

cagctgatga tcccggtgaa gttcctattc cgaagttcct attctccaga aagtatagga     4200

acttcactag agcttgcggc cgcgcatgct gacttaatca gctaacgcca ctcgacctgc     4260

aggcatgccc gcggatatcg atgggccccg gccgaagctt caagtttgta caaaaaagca     4320

ggctggcgcc ggaaccaatt cagtcgactg gatccggtac cgaattcgcg gccgcactcg     4380

agatatctag acccagcttt cttgtacaaa gtggccgtta acggatcggc cagaatccgg     4440

taagtgacta gggtcacgtg accctagtca cttaaattcg gccagaatgg ccatctggat     4500

tcagcaggcc tagaaggccc ggaccgatta aactttaatt cggtccgggt tacctctaga     4560

aagcttgtcg acctgcagac acgacatgat ggaacgtgac taaggtgggt ttttgacttt     4620

gcatgtcgaa gtgagagtga ttttattgag agaataatag aagacctaca aaacaaatga     4680

tcccgacgct aaagtaagta cgagagttaa gagaataaat gggaaaatat gcatacatga     4740

ttaggtgtgt gttcgtctca agaaagtacg aatgaatatg gtgtgtttgt agtacatgaa     4800

tgatgtgttt tgagggttca agggaaattg atatttatag agtgaaatgg aaccagaggt     4860

ctttgttgac aagggttgtt atgactcttg caaataatta atagcttata aataatagcc     4920

aataacttat tatagataga gttagagata atatatagct aaatttgaac aaggcataca     4980

aaacaaaaat gctaaatatg aataagacaa tcaaaattgt agtcgatgtt caactctttg     5040

tcgttgaaga acttgtttgc agtggtatag taaatgggtg tgagtgcagt gtctcaccca     5100

tctcacacca cacaaccaac ttcatatcta aagatattgt cgctgaatac aaaattgagt     5160

tatggaatat acaattcata atatagatac gaaaaatcat ttcttacaaa acattcaatc     5220

aaaaattatt caaacataat tctagattaa gtaatccgaa gtacaagtta gtatcctaga     5280

tccgttaatt taaaattatg tttgcataat tttggatttg gtgttctata agggcacaat     5340

tttgttcatt cttacaagtt tgtcaattct aaaatatatg caaatttgaa gaaaaaaaat     5400

ttacgaatgt gtctcaaaca ataacttaat gggaggagaa tgagggatga agaagctcaa     5460

aattaccaac gccttctacc tcaagaagct acttcacaca aaatatgact ggcggaagga     5520

taggggacaa ccgataacga gaaggagata cataaggtaa tgtacgttgt tgtgtgaggg     5580

atccggtcac ctaagtgact agggtcacgt gaccctagtc acttattccc gggcaacttt     5640

attatacaaa gttgatagat ctcgaattca ttccgattaa tcgtgg                    5686


<210>  300
<211>  6611
<212>  DNA
<213>  Artificial sequence

<220>
<223>  U6-9.1-DD20CR2+EF1A2-CAS9

<400>  300
cgcgccggta cccgggttaa gagaattgta agtgtgcttt tatatattta aaattaatat       60

attttgaaat gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt      120

aataaagata aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg      180

ctcttaaatt tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag      240

catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa gtgaagggaa      300

tccagtttgt tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag      360

caaaatggga atgcgaggta tcttcctttc gttaggggag caccagatgc atagttagtc      420

ccacattgat gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc      480

ttgacatgat ggaacgtgac tagttttaga gctagaaata gcaagttaaa ataaggctag      540

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg ccgcaattgg      600

atcgggttta cttattttgt gggtatctat acttttatta gatttttaat caggctcctg      660

atttcttttt atttcgattg aattcctgaa cttgtattat tcagtagatc gaataaatta      720

taaaaagata aaatcataaa ataatatttt atcctatcaa tcatattaaa gcaatgaata      780

tgtaaaatta atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa      840

taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat cataaaggtt      900

tagtattttt ttaaaataaa tataggaata gttttactat tcactgcttt aatagaaaaa      960

tagtttaaaa tttaagatag ttttaatccc agcatttgcc acgtttgaac gtgagccgaa     1020

acgatgtcgt tacattatct taacctagct gaaacgatgt cgtcataata tcgccaaatg     1080

ccaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa     1140

ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag agcacagtaa     1200

ccttcaaata agcgaatggg gcataatcag aaatccgaaa taaacctagg ggcattatcg     1260

gaaatgaaaa gtagctcact caatataaaa atctaggaac cctagttttc gttatcactc     1320

tgtgctccct cgctctattt ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg     1380

accttcttcg tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat     1440

gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta tgctttatgc     1500

tgttgatgtt cggttgtttg tttcgctttg tttttgtggt tcagtttttt aggattcttt     1560

tggtttttga atcgattaat cggaagagat tttcgagtta tttggtgtgt tggaggtgaa     1620

tctttttttt gaggtcatag atctgttgta tttgtgttat aaacatgcga ctttgtatga     1680

ttttttacga ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat     1740

gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat taaaagtttt     1800

ttaagcatgt tgaaggagtc ttgtagatat gtaaccgtcg atagtttttt tgtgggtttg     1860

ttcacatgtt atcaagctta atcttttact atgtatgcga ccatatctgg atccagcaaa     1920

ggcgattttt taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt     1980

aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct ttgtgatagt     2040

ttaatttata tgtattttga gttctgactt gtatttcttt gaattgattc tagtttaagt     2100

aatccatgga caaaaagtac tcaatagggc tcgacatagg gactaactcc gttggatggg     2160

ccgtcatcac cgacgagtac aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg     2220

acaggcacag cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg     2280

ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg aagaacagaa     2340

tctgctacct gcaggagatc ttctccaacg agatggccaa ggtggacgac tccttcttcc     2400

accgccttga ggaatcattc ctggtggagg aggataaaaa gcacgagaga cacccaatct     2460

tcgggaacat cgtcgacgag gtggcctacc atgaaaagta ccctaccatc taccacctga     2520

ggaagaagct ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg     2580

ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac ccagacaact     2640

ccgacgtgga caagctcttc atccagctcg ttcagaccta caaccagctt ttcgaggaga     2700

acccaatcaa cgccagtgga gttgacgcca aggctatcct ctctgctcgt ctgtcaaagt     2760

ccaggaggct tgagaacttg attgcccagc tgcctggcga aaagaagaac ggactgttcg     2820

gaaacttgat cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg     2880

ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc gacaacttgc     2940

tggcccagat aggcgaccaa tacgccgatc tcttcctcgc cgctaagaac ttgtccgacg     3000

caatcctgct gtccgacatc ctgagagtca acactgagat taccaaagct cctctgtctg     3060

cttccatgat taagcgctac gacgagcacc accaagatct gaccctgctc aaggccctgg     3120

tgagacagca gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct     3180

acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc atcaagccca     3240

tccttgagaa gatggacggt accgaggagc tgttggtgaa gttgaacaga gaggacctgt     3300

tgaggaagca gagaaccttc gacaacggaa gcatccctca ccaaatccac ctgggagagc     3360

tccacgccat cttgaggagg caggaggatt tctatccctt cctgaaggac aaccgcgaga     3420

agattgagaa gatcttgacc ttcagaattc cttactacgt cgggccactc gccagaggaa     3480

actctaggtt cgcctggatg acccgcaaat ctgaagagac cattactccc tggaacttcg     3540

aggaagtcgt ggacaagggc gcttccgctc agtctttcat cgagaggatg accaacttcg     3600

ataaaaatct gcccaacgag aaggtgctgc ccaagcactc cctgttgtac gagtatttca     3660

cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga gggaatgagg aagcctgcct     3720

tcttgtccgg agagcagaag aaggccatcg tcgacctgct cttcaagacc aacaggaagg     3780

tgactgtcaa gcagctgaag gaggactact tcaagaagat cgagtgcttc gactccgtcg     3840

agatctctgg tgtcgaggac aggttcaacg cctcccttgg gacttaccac gatctgctca     3900

agattattaa agacaaggac ttcctggaca acgaggagaa cgaggacatc cttgaggaca     3960

tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat cgaagagagg ctcaagacct     4020

acgcccacct cttcgacgac aaggtgatga aacagctgaa gagacgcaga tataccggct     4080

ggggaaggct ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca gggaagacta     4140

tactcgactt cctgaagtcc gacggattcg ccaacaggaa cttcatgcag ctcattcacg     4200

acgactcctt gaccttcaag gaggacatcc agaaggctca ggtgtctgga cagggtgact     4260

ccttgcatga gcacattgct aacttggccg gctctcccgc tattaagaag ggcattttgc     4320

agaccgtgaa ggtcgttgac gagctcgtga aggtgatggg acgccacaag ccagagaaca     4380

tcgttattga gatggctcgc gagaaccaaa ctacccagaa agggcagaag aattcccgcg     4440

agaggatgaa gcgcattgag gagggcataa aagagcttgg ctctcagatc ctcaaggagc     4500

accccgtcga gaacactcag ctgcagaacg agaagctgta cctgtactac ctccaaaacg     4560

gaagggacat gtacgtggac caggagctgg acatcaacag gttgtccgac tacgacgtcg     4620

accacatcgt gcctcagtcc ttcctgaagg atgactccat cgacaataaa gtgctgacac     4680

gctccgataa aaatagaggc aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga     4740

tgaaaaacta ctggagacag ctcttgaacg ccaagctcat cacccagcgt aagttcgaca     4800

acctgactaa ggctgagaga ggaggattgt ccgagctcga taaggccgga ttcatcaaga     4860

gacagctcgt cgaaacccgc caaattacca agcacgtggc ccaaattctg gattcccgca     4920

tgaacaccaa gtacgatgaa aatgacaagc tgatccgcga ggtcaaggtg atcaccttga     4980

agtccaagct ggtctccgac ttccgcaagg acttccagtt ctacaaggtg agggagatca     5040

acaactacca ccacgcacac gacgcctacc tcaacgctgt cgttggaacc gccctcatca     5100

aaaaatatcc taagctggag tctgagttcg tctacggcga ctacaaggtg tacgacgtga     5160

ggaagatgat cgctaagtct gagcaggaga tcggcaaggc caccgccaag tacttcttct     5220

actccaacat catgaacttc ttcaagaccg agatcactct cgccaacggt gagatcagga     5280

agcgcccact gatcgagacc aacggtgaga ctggagagat cgtgtgggac aaagggaggg     5340

atttcgctac tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg     5400

aagttcagac cggaggattc tccaaggagt ccatcctccc caagagaaac tccgacaagc     5460

tgatcgctag aaagaaagac tgggacccta agaagtacgg aggcttcgat tctcctaccg     5520

tggcctactc tgtgctggtc gtggccaagg tggagaaggg caagtccaag aagctgaaat     5580

ccgtcaagga gctcctcggg attaccatca tggagaggag ttccttcgag aagaacccta     5640

tcgacttcct ggaggccaag ggatataaag aggtgaagaa ggacctcatc atcaagctgc     5700

ccaagtactc cctcttcgag ttggagaacg gaaggaagag gatgctggct tctgccggag     5760

agttgcagaa gggaaatgag ctcgcccttc cctccaagta cgtgaacttc ctgtacctcg     5820

cctctcacta tgaaaagttg aagggctctc ctgaggacaa cgagcagaag cagctcttcg     5880

tggagcagca caagcactac ctggacgaaa ttatcgagca gatctctgag ttctccaagc     5940

gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac aagcacaggg     6000

ataagcccat tcgcgagcag gctgaaaaca ttatccacct gtttaccctc acaaacttgg     6060

gagcccctgc tgccttcaag tacttcgaca ccaccattga caggaagaga tacacctcca     6120

ccaaggaggt gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa     6180

ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag aagagaaagg     6240

tgtaggttaa cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat     6300

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt     6360

tatgtgtaat tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct     6420

aaatgaatgt cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa     6480

tccatataca tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa     6540

tctagtctag gtgtgttttg cgaattcgat atcaagctta tcgataccgt cgaggggggg     6600

cccggtaccg g                                                          6611


<210>  301
<211>  6611
<212>  DNA
<213>  Artificial sequence

<220>
<223>  U6-9.1:DD43CR1+EF1A2:CAS9

<400>  301
cgcgccggta cccgggttaa gagaattgta agtgtgcttt tatatattta aaattaatat       60

attttgaaat gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt      120

aataaagata aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg      180

ctcttaaatt tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag      240

catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa gtgaagggaa      300

tccagtttgt tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag      360

caaaatggga atgcgaggta tcttcctttc gttaggggag caccagatgc atagttagtc      420

ccacattgat gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc      480

ttgtcccttg tacttgtacg tagttttaga gctagaaata gcaagttaaa ataaggctag      540

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg ccgcaattgg      600

atcgggttta cttattttgt gggtatctat acttttatta gatttttaat caggctcctg      660

atttcttttt atttcgattg aattcctgaa cttgtattat tcagtagatc gaataaatta      720

taaaaagata aaatcataaa ataatatttt atcctatcaa tcatattaaa gcaatgaata      780

tgtaaaatta atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa      840

taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat cataaaggtt      900

tagtattttt ttaaaataaa tataggaata gttttactat tcactgcttt aatagaaaaa      960

tagtttaaaa tttaagatag ttttaatccc agcatttgcc acgtttgaac gtgagccgaa     1020

acgatgtcgt tacattatct taacctagct gaaacgatgt cgtcataata tcgccaaatg     1080

ccaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa     1140

ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag agcacagtaa     1200

ccttcaaata agcgaatggg gcataatcag aaatccgaaa taaacctagg ggcattatcg     1260

gaaatgaaaa gtagctcact caatataaaa atctaggaac cctagttttc gttatcactc     1320

tgtgctccct cgctctattt ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg     1380

accttcttcg tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat     1440

gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta tgctttatgc     1500

tgttgatgtt cggttgtttg tttcgctttg tttttgtggt tcagtttttt aggattcttt     1560

tggtttttga atcgattaat cggaagagat tttcgagtta tttggtgtgt tggaggtgaa     1620

tctttttttt gaggtcatag atctgttgta tttgtgttat aaacatgcga ctttgtatga     1680

ttttttacga ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat     1740

gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat taaaagtttt     1800

ttaagcatgt tgaaggagtc ttgtagatat gtaaccgtcg atagtttttt tgtgggtttg     1860

ttcacatgtt atcaagctta atcttttact atgtatgcga ccatatctgg atccagcaaa     1920

ggcgattttt taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt     1980

aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct ttgtgatagt     2040

ttaatttata tgtattttga gttctgactt gtatttcttt gaattgattc tagtttaagt     2100

aatccatgga caaaaagtac tcaatagggc tcgacatagg gactaactcc gttggatggg     2160

ccgtcatcac cgacgagtac aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg     2220

acaggcacag cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg     2280

ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg aagaacagaa     2340

tctgctacct gcaggagatc ttctccaacg agatggccaa ggtggacgac tccttcttcc     2400

accgccttga ggaatcattc ctggtggagg aggataaaaa gcacgagaga cacccaatct     2460

tcgggaacat cgtcgacgag gtggcctacc atgaaaagta ccctaccatc taccacctga     2520

ggaagaagct ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg     2580

ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac ccagacaact     2640

ccgacgtgga caagctcttc atccagctcg ttcagaccta caaccagctt ttcgaggaga     2700

acccaatcaa cgccagtgga gttgacgcca aggctatcct ctctgctcgt ctgtcaaagt     2760

ccaggaggct tgagaacttg attgcccagc tgcctggcga aaagaagaac ggactgttcg     2820

gaaacttgat cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg     2880

ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc gacaacttgc     2940

tggcccagat aggcgaccaa tacgccgatc tcttcctcgc cgctaagaac ttgtccgacg     3000

caatcctgct gtccgacatc ctgagagtca acactgagat taccaaagct cctctgtctg     3060

cttccatgat taagcgctac gacgagcacc accaagatct gaccctgctc aaggccctgg     3120

tgagacagca gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct     3180

acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc atcaagccca     3240

tccttgagaa gatggacggt accgaggagc tgttggtgaa gttgaacaga gaggacctgt     3300

tgaggaagca gagaaccttc gacaacggaa gcatccctca ccaaatccac ctgggagagc     3360

tccacgccat cttgaggagg caggaggatt tctatccctt cctgaaggac aaccgcgaga     3420

agattgagaa gatcttgacc ttcagaattc cttactacgt cgggccactc gccagaggaa     3480

actctaggtt cgcctggatg acccgcaaat ctgaagagac cattactccc tggaacttcg     3540

aggaagtcgt ggacaagggc gcttccgctc agtctttcat cgagaggatg accaacttcg     3600

ataaaaatct gcccaacgag aaggtgctgc ccaagcactc cctgttgtac gagtatttca     3660

cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga gggaatgagg aagcctgcct     3720

tcttgtccgg agagcagaag aaggccatcg tcgacctgct cttcaagacc aacaggaagg     3780

tgactgtcaa gcagctgaag gaggactact tcaagaagat cgagtgcttc gactccgtcg     3840

agatctctgg tgtcgaggac aggttcaacg cctcccttgg gacttaccac gatctgctca     3900

agattattaa agacaaggac ttcctggaca acgaggagaa cgaggacatc cttgaggaca     3960

tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat cgaagagagg ctcaagacct     4020

acgcccacct cttcgacgac aaggtgatga aacagctgaa gagacgcaga tataccggct     4080

ggggaaggct ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca gggaagacta     4140

tactcgactt cctgaagtcc gacggattcg ccaacaggaa cttcatgcag ctcattcacg     4200

acgactcctt gaccttcaag gaggacatcc agaaggctca ggtgtctgga cagggtgact     4260

ccttgcatga gcacattgct aacttggccg gctctcccgc tattaagaag ggcattttgc     4320

agaccgtgaa ggtcgttgac gagctcgtga aggtgatggg acgccacaag ccagagaaca     4380

tcgttattga gatggctcgc gagaaccaaa ctacccagaa agggcagaag aattcccgcg     4440

agaggatgaa gcgcattgag gagggcataa aagagcttgg ctctcagatc ctcaaggagc     4500

accccgtcga gaacactcag ctgcagaacg agaagctgta cctgtactac ctccaaaacg     4560

gaagggacat gtacgtggac caggagctgg acatcaacag gttgtccgac tacgacgtcg     4620

accacatcgt gcctcagtcc ttcctgaagg atgactccat cgacaataaa gtgctgacac     4680

gctccgataa aaatagaggc aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga     4740

tgaaaaacta ctggagacag ctcttgaacg ccaagctcat cacccagcgt aagttcgaca     4800

acctgactaa ggctgagaga ggaggattgt ccgagctcga taaggccgga ttcatcaaga     4860

gacagctcgt cgaaacccgc caaattacca agcacgtggc ccaaattctg gattcccgca     4920

tgaacaccaa gtacgatgaa aatgacaagc tgatccgcga ggtcaaggtg atcaccttga     4980

agtccaagct ggtctccgac ttccgcaagg acttccagtt ctacaaggtg agggagatca     5040

acaactacca ccacgcacac gacgcctacc tcaacgctgt cgttggaacc gccctcatca     5100

aaaaatatcc taagctggag tctgagttcg tctacggcga ctacaaggtg tacgacgtga     5160

ggaagatgat cgctaagtct gagcaggaga tcggcaaggc caccgccaag tacttcttct     5220

actccaacat catgaacttc ttcaagaccg agatcactct cgccaacggt gagatcagga     5280

agcgcccact gatcgagacc aacggtgaga ctggagagat cgtgtgggac aaagggaggg     5340

atttcgctac tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg     5400

aagttcagac cggaggattc tccaaggagt ccatcctccc caagagaaac tccgacaagc     5460

tgatcgctag aaagaaagac tgggacccta agaagtacgg aggcttcgat tctcctaccg     5520

tggcctactc tgtgctggtc gtggccaagg tggagaaggg caagtccaag aagctgaaat     5580

ccgtcaagga gctcctcggg attaccatca tggagaggag ttccttcgag aagaacccta     5640

tcgacttcct ggaggccaag ggatataaag aggtgaagaa ggacctcatc atcaagctgc     5700

ccaagtactc cctcttcgag ttggagaacg gaaggaagag gatgctggct tctgccggag     5760

agttgcagaa gggaaatgag ctcgcccttc cctccaagta cgtgaacttc ctgtacctcg     5820

cctctcacta tgaaaagttg aagggctctc ctgaggacaa cgagcagaag cagctcttcg     5880

tggagcagca caagcactac ctggacgaaa ttatcgagca gatctctgag ttctccaagc     5940

gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac aagcacaggg     6000

ataagcccat tcgcgagcag gctgaaaaca ttatccacct gtttaccctc acaaacttgg     6060

gagcccctgc tgccttcaag tacttcgaca ccaccattga caggaagaga tacacctcca     6120

ccaaggaggt gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa     6180

ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag aagagaaagg     6240

tgtaggttaa cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat     6300

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt     6360

tatgtgtaat tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct     6420

aaatgaatgt cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa     6480

tccatataca tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa     6540

tctagtctag gtgtgttttg cgaattcgat atcaagctta tcgataccgt cgaggggggg     6600

cccggtaccg g                                                          6611


<210>  302
<211>  5719
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43HR1-SAMS:HPT-DD43HR2

<400>  302
cgcgcctcta gttgaagaca cgttcatgtc ttcatcgtaa gaagacactc agtagtcttc       60

ggccagaatg gccatctgga ttcagcaggc ctagaaggcc atttaaatcc tgaggatctg      120

gtcttcctaa ggacccggga tatcgctatc aactttgtat agaaaagttg ggccgaattc      180

gagctcggta cggccagaat ccggtaagtg actagggtca cgtgacccta gtcacttaaa      240

ttcggccaga atggccatct ggattcagca ggcctagaag gcccggaccg attaaacttt      300

aattcggtcc gggttacctc gagatcttgt tcccctcctt ggtttggcat aaattgattt      360

tcatggctct tctcggtcga aactggagct aattcaccct tagtctctct taaaattctg      420

gctgtaagaa acaccacaga acacataaat tataaactaa ttataatttg aagagtaaaa      480

tatgttttta ctcttatgat ttaattagtg tagttttaat tttctccttt ttttaaaaaa      540

ttttggtatt cataaatttc aattttttaa aaataattgt tgttacccgt taatgataac      600

gggatatgtt atgttaccac taaatcggac aaaaaaaatt caaaactttt ataaggatta      660

aaattaacaa aaatatttta aaaaaatcta acctcaataa agttaaattt ataagcacaa      720

aataatactt ttaagcctaa tttggcaaga cacaagcaag ctcacctgta gcattaatag      780

aaaggaagca aagcaagaga aaagcaacca gaaggaagcg tttgcttggt gacacagcca      840

tcttacttga atttatggta ttactgagaa accttgatct tgcttcaaaa tcttctagtt      900

accctctttt tataggcaga aagagaacta gctagttgcc aataggatat gaggacatgt      960

ggtgcaatgc actcactctt caaggacaag aaaaacaatg gctacaattg tggttcaaat     1020

caatgtctcc tgctctgtcc tgcctgaaaa tgacaccctt ttgcttggaa aagaggatca     1080

aagctaagaa caggagtggc ttcattccct tcatgtaacc aaacactttc gcattctgtc     1140

attcgtgaat cagcaaaatc tgcaaccaaa aatatatggt gcctaaataa aagaaataaa     1200

ataatttaga gttgcggact aaaataataa acaaaagaaa tatattataa tctagaatta     1260

atttaggact aaaagaagag gcagactcca attcctcttt tctagaatac cctccgtacg     1320

tacactagtg gtcacctaag tgactagggt cacgtgaccc tagtcactta ttcccaaaca     1380

ctagtaacgg ccgccagtgt gctggaattc gcccttccca agctttgctc tagatcaaac     1440

tcacatccaa acataacatg gatatcttcc ttaccaatca tactaattat tttgggttaa     1500

atattaatca ttatttttaa gatattaatt aagaaattaa aagatttttt aaaaaaatgt     1560

ataaaattat attattcatg atttttcata catttgattt tgataataaa tatatttttt     1620

ttaatttctt aaaaaatgtt gcaagacact tattagacat agtcttgttc tgtttacaaa     1680

agcattcatc atttaataca ttaaaaaata tttaatacta acagtagaat cttcttgtga     1740

gtggtgtggg agtaggcaac ctggcattga aacgagagaa agagagtcag aaccagaaga     1800

caaataaaaa gtatgcaaca aacaaatcaa aatcaaaggg caaaggctgg ggttggctca     1860

attggttgct acattcaatt ttcaactcag tcaacggttg agattcactc tgacttcccc     1920

aatctaagcc gcggatgcaa acggttgaat ctaacccaca atccaatctc gttacttagg     1980

ggcttttccg tcattaactc acccctgcca cccggtttcc ctataaattg gaactcaatg     2040

ctcccctcta aactcgtatc gcttcagagt tgagaccaag acacactcgt tcatatatct     2100

ctctgctctt ctcttctctt ctacctctca aggtactttt cttctccctc taccaaatcc     2160

tagattccgt ggttcaattt cggatcttgc acttctggtt tgctttgcct tgctttttcc     2220

tcaactgggt ccatctagga tccatgtgaa actctactct ttctttaata tctgcggaat     2280

acgcgtttga ctttcagatc tagtcgaaat catttcataa ttgcctttct ttcttttagc     2340

ttatgagaaa taaaatcact ttttttttat ttcaaaataa accttgggcc ttgtgctgac     2400

tgagatgggg tttggtgatt acagaatttt agcgaatttt gtaattgtac ttgtttgtct     2460

gtagttttgt tttgttttct tgtttctcat acattcctta ggcttcaatt ttattcgagt     2520

ataggtcaca ataggaattc aaactttgag caggggaatt aatcccttcc ttcaaatcca     2580

gtttgtttgt atatatgttt aaaaaatgaa acttttgctt taaattctat tataactttt     2640

tttatggctg aaatttttgc atgtgtcttt gctctctgtt gtaaatttac tgtttaggta     2700

ctaactctag gcttgttgtg cagtttttga agtataacaa cagaagttcc tattccgaag     2760

ttcctattct ctagaaagta taggaacttc cactagtcca tgaaaaagcc tgaactcacc     2820

gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag     2880

ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc     2940

ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt     3000

gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaattcag cgagagcctg     3060

acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa     3120

ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt     3180

agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg     3240

cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac     3300

gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac     3360

tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac     3420

aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac     3480

gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc     3540

tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc     3600

cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct     3660

tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca     3720

caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat     3780

agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagtgagg tacctaaaga     3840

aggagtgcgt cgaagcagat cgttcaaaca tttggcaata aagtttctta agattgaatc     3900

ctgttgccgg tcttgcgatg attatcatat aatttctgtt gaattacgtt aagcatgtaa     3960

taattaacat gtaatgcatg acgttattta tgagatgggt ttttatgatt agagtcccgc     4020

aattatacat ttaatacgcg atagaaaaca aaatatagcg cgcaaactag gataaattat     4080

cgcgcgcggt gtcatctatg ttactagatc gatgtcgacc cgggccctag gaggccggcc     4140

cagctgatga tcccggtgaa gttcctattc cgaagttcct attctccaga aagtatagga     4200

acttcactag agcttgcggc cgcgcatgct gacttaatca gctaacgcca ctcgacctgc     4260

aggcatgccc gcggatatcg atgggccccg gccgaagctt caagtttgta caaaaaagca     4320

ggctggcgcc ggaaccaatt cagtcgactg gatccggtac cgaattcgcg gccgcactcg     4380

agatatctag acccagcttt cttgtacaaa gtggccgtta acggatcggc cagaatccgg     4440

taagtgacta gggtcacgtg accctagtca cttaaattcg gccagaatgg ccatctggat     4500

tcagcaggcc tagaaggccc ggaccgatta aactttaatt cggtccgggt tacctctaga     4560

aagcttgtcg acctgcaggt acaagtacaa gggacttgtg agttgtaagg ctgtatttac     4620

aatagtgaaa agagaatcat ctgggtgatt gggtttttag tccccagtga cgaattaaag     4680

gtttgaattc ttagtatgtt tgggaatcaa ttaggaattt cgttttggac tttccaaagc     4740

aattattcac tttttcattc attaaatgtg actaaaaaat tgttatttct ccattggcca     4800

ggatgcatcg tttatataaa cataacctta gtgaaagcag tgttttcatg tgacagcggc     4860

agactatatc ttaaacaaaa ttacttgtaa agaaagatac cgttaggaaa aaaatgaaaa     4920

gaaaattgaa gctatcactt gtttactttc ctaatatctt tcaagaatac aatgtggtga     4980

atttcaattt tccctacata tgtataccgt cagcctgacg caacttatga aacttctctt     5040

tctttcattt gatgtatata taaagacaca ttatatataa agaaacttta tatatatctc     5100

catcatattt tagtacttgc tactatgtaa aattagctgt tggaagtatc tcaagaaaca     5160

tttaatttat tgaaccaagc attaaccatt catctacatt tgagttctaa aataaatctt     5220

aaatgatgtg gaggaaggga aattgttaat tatttccctc ttctcctaca tggatatacc     5280

tgaaacatgc aatggatgga ttagatttta acatttgcag cctgagaagt tcactgactt     5340

tcctccagct attttatgtg tgcccgccac catttatagc tcatgattgt agctgaactg     5400

caaaaactgc atcgattgca aactgaaatt gagaatctct tttcaacttt atatgctgat     5460

tgatgcatgc tgagcatgct atactagtac tcgaagttcc tatatgtaga ctttgttact     5520

gcctaatata ctttgtgttt gttctcaagt tcttatttta tttcatattt tttcctataa     5580

aaggttaatg gctctataaa ggttgagtga cggatccggt cacctaagtg actagggtca     5640

cgtgacccta gtcacttatt cccgggcaac tttattatac aaagttgata gatctcgaat     5700

tcattccgat taatcgtgg                                                  5719


<210>  303
<211>  6611
<212>  DNA
<213>  Artificial sequence

<220>
<223>  U6-9.1:DD43CR2+EF1A2:CAS9

<400>  303
cgcgccggta cccgggttaa gagaattgta agtgtgcttt tatatattta aaattaatat       60

attttgaaat gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt      120

aataaagata aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg      180

ctcttaaatt tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag      240

catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa gtgaagggaa      300

tccagtttgt tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag      360

caaaatggga atgcgaggta tcttcctttc gttaggggag caccagatgc atagttagtc      420

ccacattgat gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc      480

ttgtattcta gaaaagagga atgttttaga gctagaaata gcaagttaaa ataaggctag      540

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg ccgcaattgg      600

atcgggttta cttattttgt gggtatctat acttttatta gatttttaat caggctcctg      660

atttcttttt atttcgattg aattcctgaa cttgtattat tcagtagatc gaataaatta      720

taaaaagata aaatcataaa ataatatttt atcctatcaa tcatattaaa gcaatgaata      780

tgtaaaatta atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa      840

taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat cataaaggtt      900

tagtattttt ttaaaataaa tataggaata gttttactat tcactgcttt aatagaaaaa      960

tagtttaaaa tttaagatag ttttaatccc agcatttgcc acgtttgaac gtgagccgaa     1020

acgatgtcgt tacattatct taacctagct gaaacgatgt cgtcataata tcgccaaatg     1080

ccaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa     1140

ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag agcacagtaa     1200

ccttcaaata agcgaatggg gcataatcag aaatccgaaa taaacctagg ggcattatcg     1260

gaaatgaaaa gtagctcact caatataaaa atctaggaac cctagttttc gttatcactc     1320

tgtgctccct cgctctattt ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg     1380

accttcttcg tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat     1440

gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta tgctttatgc     1500

tgttgatgtt cggttgtttg tttcgctttg tttttgtggt tcagtttttt aggattcttt     1560

tggtttttga atcgattaat cggaagagat tttcgagtta tttggtgtgt tggaggtgaa     1620

tctttttttt gaggtcatag atctgttgta tttgtgttat aaacatgcga ctttgtatga     1680

ttttttacga ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat     1740

gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat taaaagtttt     1800

ttaagcatgt tgaaggagtc ttgtagatat gtaaccgtcg atagtttttt tgtgggtttg     1860

ttcacatgtt atcaagctta atcttttact atgtatgcga ccatatctgg atccagcaaa     1920

ggcgattttt taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt     1980

aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct ttgtgatagt     2040

ttaatttata tgtattttga gttctgactt gtatttcttt gaattgattc tagtttaagt     2100

aatccatgga caaaaagtac tcaatagggc tcgacatagg gactaactcc gttggatggg     2160

ccgtcatcac cgacgagtac aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg     2220

acaggcacag cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg     2280

ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg aagaacagaa     2340

tctgctacct gcaggagatc ttctccaacg agatggccaa ggtggacgac tccttcttcc     2400

accgccttga ggaatcattc ctggtggagg aggataaaaa gcacgagaga cacccaatct     2460

tcgggaacat cgtcgacgag gtggcctacc atgaaaagta ccctaccatc taccacctga     2520

ggaagaagct ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg     2580

ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac ccagacaact     2640

ccgacgtgga caagctcttc atccagctcg ttcagaccta caaccagctt ttcgaggaga     2700

acccaatcaa cgccagtgga gttgacgcca aggctatcct ctctgctcgt ctgtcaaagt     2760

ccaggaggct tgagaacttg attgcccagc tgcctggcga aaagaagaac ggactgttcg     2820

gaaacttgat cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg     2880

ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc gacaacttgc     2940

tggcccagat aggcgaccaa tacgccgatc tcttcctcgc cgctaagaac ttgtccgacg     3000

caatcctgct gtccgacatc ctgagagtca acactgagat taccaaagct cctctgtctg     3060

cttccatgat taagcgctac gacgagcacc accaagatct gaccctgctc aaggccctgg     3120

tgagacagca gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct     3180

acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc atcaagccca     3240

tccttgagaa gatggacggt accgaggagc tgttggtgaa gttgaacaga gaggacctgt     3300

tgaggaagca gagaaccttc gacaacggaa gcatccctca ccaaatccac ctgggagagc     3360

tccacgccat cttgaggagg caggaggatt tctatccctt cctgaaggac aaccgcgaga     3420

agattgagaa gatcttgacc ttcagaattc cttactacgt cgggccactc gccagaggaa     3480

actctaggtt cgcctggatg acccgcaaat ctgaagagac cattactccc tggaacttcg     3540

aggaagtcgt ggacaagggc gcttccgctc agtctttcat cgagaggatg accaacttcg     3600

ataaaaatct gcccaacgag aaggtgctgc ccaagcactc cctgttgtac gagtatttca     3660

cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga gggaatgagg aagcctgcct     3720

tcttgtccgg agagcagaag aaggccatcg tcgacctgct cttcaagacc aacaggaagg     3780

tgactgtcaa gcagctgaag gaggactact tcaagaagat cgagtgcttc gactccgtcg     3840

agatctctgg tgtcgaggac aggttcaacg cctcccttgg gacttaccac gatctgctca     3900

agattattaa agacaaggac ttcctggaca acgaggagaa cgaggacatc cttgaggaca     3960

tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat cgaagagagg ctcaagacct     4020

acgcccacct cttcgacgac aaggtgatga aacagctgaa gagacgcaga tataccggct     4080

ggggaaggct ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca gggaagacta     4140

tactcgactt cctgaagtcc gacggattcg ccaacaggaa cttcatgcag ctcattcacg     4200

acgactcctt gaccttcaag gaggacatcc agaaggctca ggtgtctgga cagggtgact     4260

ccttgcatga gcacattgct aacttggccg gctctcccgc tattaagaag ggcattttgc     4320

agaccgtgaa ggtcgttgac gagctcgtga aggtgatggg acgccacaag ccagagaaca     4380

tcgttattga gatggctcgc gagaaccaaa ctacccagaa agggcagaag aattcccgcg     4440

agaggatgaa gcgcattgag gagggcataa aagagcttgg ctctcagatc ctcaaggagc     4500

accccgtcga gaacactcag ctgcagaacg agaagctgta cctgtactac ctccaaaacg     4560

gaagggacat gtacgtggac caggagctgg acatcaacag gttgtccgac tacgacgtcg     4620

accacatcgt gcctcagtcc ttcctgaagg atgactccat cgacaataaa gtgctgacac     4680

gctccgataa aaatagaggc aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga     4740

tgaaaaacta ctggagacag ctcttgaacg ccaagctcat cacccagcgt aagttcgaca     4800

acctgactaa ggctgagaga ggaggattgt ccgagctcga taaggccgga ttcatcaaga     4860

gacagctcgt cgaaacccgc caaattacca agcacgtggc ccaaattctg gattcccgca     4920

tgaacaccaa gtacgatgaa aatgacaagc tgatccgcga ggtcaaggtg atcaccttga     4980

agtccaagct ggtctccgac ttccgcaagg acttccagtt ctacaaggtg agggagatca     5040

acaactacca ccacgcacac gacgcctacc tcaacgctgt cgttggaacc gccctcatca     5100

aaaaatatcc taagctggag tctgagttcg tctacggcga ctacaaggtg tacgacgtga     5160

ggaagatgat cgctaagtct gagcaggaga tcggcaaggc caccgccaag tacttcttct     5220

actccaacat catgaacttc ttcaagaccg agatcactct cgccaacggt gagatcagga     5280

agcgcccact gatcgagacc aacggtgaga ctggagagat cgtgtgggac aaagggaggg     5340

atttcgctac tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg     5400

aagttcagac cggaggattc tccaaggagt ccatcctccc caagagaaac tccgacaagc     5460

tgatcgctag aaagaaagac tgggacccta agaagtacgg aggcttcgat tctcctaccg     5520

tggcctactc tgtgctggtc gtggccaagg tggagaaggg caagtccaag aagctgaaat     5580

ccgtcaagga gctcctcggg attaccatca tggagaggag ttccttcgag aagaacccta     5640

tcgacttcct ggaggccaag ggatataaag aggtgaagaa ggacctcatc atcaagctgc     5700

ccaagtactc cctcttcgag ttggagaacg gaaggaagag gatgctggct tctgccggag     5760

agttgcagaa gggaaatgag ctcgcccttc cctccaagta cgtgaacttc ctgtacctcg     5820

cctctcacta tgaaaagttg aagggctctc ctgaggacaa cgagcagaag cagctcttcg     5880

tggagcagca caagcactac ctggacgaaa ttatcgagca gatctctgag ttctccaagc     5940

gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac aagcacaggg     6000

ataagcccat tcgcgagcag gctgaaaaca ttatccacct gtttaccctc acaaacttgg     6060

gagcccctgc tgccttcaag tacttcgaca ccaccattga caggaagaga tacacctcca     6120

ccaaggaggt gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa     6180

ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag aagagaaagg     6240

tgtaggttaa cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat     6300

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt     6360

tatgtgtaat tactagttat ctgaataaaa gagaaagaga tcatccatat ttcttatcct     6420

aaatgaatgt cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa     6480

tccatataca tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa     6540

tctagtctag gtgtgttttg cgaattcgat atcaagctta tcgataccgt cgaggggggg     6600

cccggtaccg g                                                          6611


<210>  304
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD20 qPCR amplicon

<400>  304
attcggaact gacacacgac atgatggaac gtgactaagg tgggtttttg actttgcatg       60

tcga                                                                    64


<210>  305
<211>  115
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DD43 qPCR amplicon

<400>  305
aaagaagagg cagactccaa ttcctctttt ctagaatacc ctccgtacgt acaagtacaa       60

gggacttgtg agttgtaagg ctgtatttac aatagtgaaa agagaatcat ctggg           115


<210>  306
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-CR1

<400>  306
ggaactgaca cacgacatga                                                   20


<210>  307
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-CR2

<400>  307
gacatgatgg aacgtgacta                                                   20


<210>  308
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-F

<400>  308
attcggaact gacacacgac at                                                22


<210>  309
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FAM-MGB probe, DD20-T

<400>  309
atggaacgtg actaagg                                                      17


<210>  310
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-R

<400>  310
tcgacatgca aagtcaaaaa cc                                                22


<210>  311
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43CR1

<400>  311
gtcccttgta cttgtacgta                                                   20


<210>  312
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43CR2

<400>  312
gtattctaga aaagaggaat                                                   20


<210>  313
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43-F

<400>  313
ttctagaata ccctccgtac gtacaa                                            26


<210>  314
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43-F2

<400>  314
aaagaagagg cagactccaa ttcctc                                            26


<210>  315
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FAM-MGB probe, DD43-T

<400>  315
caagggactt gtgagttgt                                                    19


<210>  316
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43-R

<400>  316
cccagatgat tctcttttca ctattg                                            26


<210>  317
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, Cas9-F

<400>  317
ccttcttcca ccgccttga                                                    19


<210>  318
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FAM-MGB probe, Cas9-T

<400>  318
aatcattcct ggtggagga                                                    19


<210>  319
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, Cas9-R

<400>  319
tgggtgtctc tcgtgctttt t                                                 21


<210>  320
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, Sams-76F

<400>  320
aggcttgttg tgcagttttt ga                                                22


<210>  321
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FAM-MGB probe, FRT1I-63T

<400>  321
tggactagtg gaagttccta ta                                                22


<210>  322
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, FRT1I-41F

<400>  322
gcggtgagtt caggcttttt c                                                 21


<210>  323
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-LB

<400>  323
ggttatacct tcttcttagt gtggtctatc c                                      31


<210>  324
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, Sams-A1

<400>  324
cccaaaataa ttagtatgat tggtaaggaa g                                      31


<210>  325
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, QC498A-S1

<400>  325
ggaacttcac tagagcttgc ggc                                               23


<210>  326
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD20-RB

<400>  326
gccattacat tcttcataag ttcctctc                                          28


<210>  327
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43-LB

<400>  327
gtgtagtcca ttgtagccaa gtcacc                                            26


<210>  328
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, DD43-RB

<400>  328
caaaccggag agagaggaag aacc                                              24


<210>  329
<211>  2105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD20 HR1-HR2 PCR amplicon

<400>  329
ggttatacct tcttcttagt gtggtctatc ccctagtaat aattacacat ctaagatatc       60

cccttctttt tcaagtaaaa taatatcata tgatctcatt ttagtgaaac aatactattt      120

ccctgataac tctcttcaac attagggact tcatctaatc atctactttc aaggtataac      180

tagacgtatt tgttctttta aaaaaaacac tagatgtact cgtcaactca aaattcatcg      240

ttcatgcatt ttaattaaac tttaattagc taatgagtag aaaaagatca tacgagtaaa      300

atagaagaat cttcctagat tttggaagaa tggattggag tgtaagtgaa ttgatccatt      360

agtggaagat gctctttaca atggccaaac tgttctaatt gttagagcac atttgagatg      420

aaacacttca gtagtggagg taacctacaa tcctaggatc tgtatcctct atcactaatg      480

gagcaatggg tttgagattg acttactcct ttccttgtct ctcgtagtgc atatgcgcac      540

tttcaaaggc tacacaaaag ccgttaactt tttgtttatt taagttacga aagatagttg      600

aattagagta aatggtgata ttgaattagg attttaaata attttaaaag aattttttta      660

ataaaaaaaa tattgtgttg ttggatcaaa atttttaaat aacatgaata aggaaatgga      720

ttgcaatgag gttttaaaca attattttaa catataggat tttagaaaga cttttataat      780

attttgttga agtttagatt ttaatatatt tatgttttaa aattttaaaa aaaacttcat      840

gaatttataa tatttgaaaa agacacgtga atatttagaa aacatttaaa attacaataa      900

taaatcataa tgagataggg tgtattcatg tgtagacgag acaccaagta tatggttcac      960

aagtgaatca tctttttttt ttacagcaca agtagatcac ttgtacttat caaaattcgg     1020

aactgacaca cgacatgatg gaacgtgact aaggtgggtt tttgactttg catgtcgaag     1080

tgagagtgat tttattgaga gaataataga agacctacaa aacaaatgat cccgacgcta     1140

aagtaagtac gagagttaag agaataaatg ggaaaatatg catacatgat taggtgtgtg     1200

ttcgtctcaa gaaagtacga atgaatatgg tgtgtttgta gtacatgaat gatgtgtttt     1260

gagggttcaa gggaaattga tatttataga gtgaaatgga accagaggtc tttgttgaca     1320

agggttgtta tgactcttgc aaataattaa tagcttataa ataatagcca ataacttatt     1380

atagatagag ttagagataa tatatagcta aatttgaaca aggcatacaa aacaaaaatg     1440

ctaaatatga ataagacaat caaaattgta gtcgatgttc aactctttgt cgttgaagaa     1500

cttgtttgca gtggtatagt aaatgggtgt gagtgcagtg tctcacccat ctcacaccac     1560

acaaccaact tcatatctaa agatattgtc gctgaataca aaattgagtt atggaatata     1620

caattcataa tatagatacg aaaaatcatt tcttacaaaa cattcaatca aaaattattc     1680

aaacataatt ctagattaag taatccgaag tacaagttag tatcctagat ccgttaattt     1740

aaaattatgt ttgcataatt ttggatttgg tgttctataa gggcacaatt ttgttcattc     1800

ttacaagttt gtcaattcta aaatatatgc aaatttgaag aaaaaaaatt tacgaatgtg     1860

tctcaaacaa taacttaatg ggaggagaat gagggatgaa gaagctcaaa attaccaacg     1920

ccttctacct caagaagcta cttcacacaa aatatgactg gcggaaggat aggggacaac     1980

cgataacgag aaggagatac ataaggtaat gtacgttgtt gtgtgaggta cacaattatg     2040

gggatgaaga agttcaactt tagtcgaaaa aatgtttgag aggaacttat gaagaatgta     2100

atggc                                                                 2105


<210>  330
<211>  1204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD20 HR1-SAMS PCR amplicon

<400>  330
ggttatacct tcttcttagt gtggtctatc ccctagtaat aattacacat ctaagatatc       60

cccttctttt tcaagtaaaa taatatcata tgatctcatt ttagtgaaac aatactattt      120

ccctgataac tctcttcaac attagggact tcatctaatc atctactttc aaggtataac      180

tagacgtatt tgttctttta aaaaaaacac tagatgtact cgtcaactca aaattcatcg      240

ttcatgcatt ttaattaaac tttaattagc taatgagtag aaaaagatca tacgagtaaa      300

atagaagaat cttcctagat tttggaagaa tggattggag tgtaagtgaa ttgatccatt      360

agtggaagat gctctttaca atggccaaac tgttctaatt gttagagcac atttgagatg      420

aaacacttca gtagtggagg taacctacaa tcctaggatc tgtatcctct atcactaatg      480

gagcaatggg tttgagattg acttactcct ttccttgtct ctcgtagtgc atatgcgcac      540

tttcaaaggc tacacaaaag ccgttaactt tttgtttatt taagttacga aagatagttg      600

aattagagta aatggtgata ttgaattagg attttaaata attttaaaag aattttttta      660

ataaaaaaaa tattgtgttg ttggatcaaa atttttaaat aacatgaata aggaaatgga      720

ttgcaatgag gttttaaaca attattttaa catataggat tttagaaaga cttttataat      780

attttgttga agtttagatt ttaatatatt tatgttttaa aattttaaaa aaaacttcat      840

gaatttataa tatttgaaaa agacacgtga atatttagaa aacatttaaa attacaataa      900

taaatcataa tgagataggg tgtattcatg tgtagacgag acaccaagta tatggttcac      960

aagtgaatca tctttttttt ttacagcaca agtagatcac ttgtacttat caaaattcgg     1020

aactgacaca cactagtggt cacctaagtg actagggtca cgtgacccta gtcacttatt     1080

cccaaacact agtaacggcc gccagtgtgc tggaattcgc ccttcccaag ctttgctcta     1140

gatcaaactc acatccaaac ataacatgga tatcttcctt accaatcata ctaattattt     1200

tggg                                                                  1204


<210>  331
<211>  1459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD20 NOS-HR2 PCR amplicon

<400>  331
ggaacttcac tagagcttgc ggccgcgcat gctgacttaa tcagctaacg ccactcgacc       60

tgcaggcatg cccgcggata tcgatgggcc ccggccgaag cttcaagttt gtacaaaaaa      120

gcaggctggc gccggaacca attcagtcga ctggatccgg taccgaattc gcggccgcac      180

tcgagatatc tagacccagc tttcttgtac aaagtggccg ttaacggatc ggccagaatc      240

cggtaagtga ctagggtcac gtgaccctag tcacttaaat tcggccagaa tggccatctg      300

gattcagcag gcctagaagg cccggaccga ttaaacttta attcggtccg ggttacctct      360

agaaagcttg tcgacctgca gacacgacat gatggaacgt gactaaggtg ggtttttgac      420

tttgcatgtc gaagtgagag tgattttatt gagagaataa tagaagacct acaaaacaaa      480

tgatcccgac gctaaagtaa gtacgagagt taagagaata aatgggaaaa tatgcataca      540

tgattaggtg tgtgttcgtc tcaagaaagt acgaatgaat atggtgtgtt tgtagtacat      600

gaatgatgtg ttttgagggt tcaagggaaa ttgatattta tagagtgaaa tggaaccaga      660

ggtctttgtt gacaagggtt gttatgactc ttgcaaataa ttaatagctt ataaataata      720

gccaataact tattatagat agagttagag ataatatata gctaaatttg aacaaggcat      780

acaaaacaaa aatgctaaat atgaataaga caatcaaaat tgtagtcgat gttcaactct      840

ttgtcgttga agaacttgtt tgcagtggta tagtaaatgg gtgtgagtgc agtgtctcac      900

ccatctcaca ccacacaacc aacttcatat ctaaagatat tgtcgctgaa tacaaaattg      960

agttatggaa tatacaattc ataatataga tacgaaaaat catttcttac aaaacattca     1020

atcaaaaatt attcaaacat aattctagat taagtaatcc gaagtacaag ttagtatcct     1080

agatccgtta atttaaaatt atgtttgcat aattttggat ttggtgttct ataagggcac     1140

aattttgttc attcttacaa gtttgtcaat tctaaaatat atgcaaattt gaagaaaaaa     1200

aatttacgaa tgtgtctcaa acaataactt aatgggagga gaatgaggga tgaagaagct     1260

caaaattacc aacgccttct acctcaagaa gctacttcac acaaaatatg actggcggaa     1320

ggatagggga caaccgataa cgagaaggag atacataagg taatgtacgt tgttgtgtga     1380

ggtacacaat tatggggatg aagaagttca actttagtcg aaaaaatgtt tgagaggaac     1440

ttatgaagaa tgtaatggc                                                  1459


<210>  332
<211>  2098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD43 HR1-HR2 PCR amplicon

<400>  332
gtgtagtcca ttgtagccaa gtcaccaata tcttgttccc ctccttggtt tggcataaat       60

tgattttcat ggctcttctc ggtcgaaact ggagctaatt cacccttagt ctctcttaaa      120

attctggctg taagaaacac cacagaacac ataaattata aactaattat aatttgaaga      180

gtaaaatatg tttttactct tatgatttaa ttagtgtagt tttaattttc tccttttttt      240

aaaaaatttt ggtattcata aatttcaatt ttttaaaaat aattgttgtt acccgttaat      300

gataacggga tatgttatgt taccactaaa tcggacaaaa aaaattcaaa acttttataa      360

ggattaaaat taacaaaaat attttaaaaa aatctaacct caataaagtt aaatttataa      420

gcacaaaata atacttttaa gcctaatttg gcaagacaca agcaagctca cctgtagcat      480

taatagaaag gaagcaaagc aagagaaaag caaccagaag gaagcgtttg cttggtgaca      540

cagccatctt acttgaattt atggtattac tgagaaacct tgatcttgct tcaaaatctt      600

ctagttaccc tctttttata ggcagaaaga gaactagcta gttgccaata ggatatgagg      660

acatgtggtg caatgcactc actcttcaag gacaagaaaa acaatggcta caattgtggt      720

tcaaatcaat gtctcctgct ctgtcctgcc tgaaaatgac acccttttgc ttggaaaaga      780

ggatcaaagc taagaacagg agtggcttca ttcccttcat gtaaccaaac actttcgcat      840

tctgtcattc gtgaatcagc aaaatctgca accaaaaata tatggtgcct aaataaaaga      900

aataaaataa tttagagttg cggactaaaa taataaacaa aagaaatata ttataatcta      960

gaattaattt aggactaaaa gaagaggcag actccaattc ctcttttcta gaataccctc     1020

cgtacgtaca agtacaaggg acttgtgagt tgtaaggctg tatttacaat agtgaaaaga     1080

gaatcatctg ggtgattggg tttttagtcc ccagtgacga attaaaggtt tgaattctta     1140

gtatgtttgg gaatcaatta ggaatttcgt tttggacttt ccaaagcaat tattcacttt     1200

ttcattcatt aaatgtgact aaaaaattgt tatttctcca ttggccagga tgcatcgttt     1260

atataaacat aaccttagtg aaagcagtgt tttcatgtga cagcggcaga ctatatctta     1320

aacaaaatta cttgtaaaga aagataccgt taggaaaaaa atgaaaagaa aattgaagct     1380

atcacttgtt tactttccta atatctttca agaatacaat gtggtgaatt tcaattttcc     1440

ctacatatgt ataccgtcag cctgacgcaa cttatgaaac ttctctttct ttcatttgat     1500

gtatatataa agacacatta tatataaaga aactttatat atatctccat catattttag     1560

tacttgctac tatgtaaaat tagctgttgg aagtatctca agaaacattt aatttattga     1620

accaagcatt aaccattcat ctacatttga gttctaaaat aaatcttaaa tgatgtggag     1680

gaagggaaat tgttaattat ttccctcttc tcctacatgg atatacctga aacatgcaat     1740

ggatggatta gattttaaca tttgcagcct gagaagttca ctgactttcc tccagctatt     1800

ttatgtgtgc ccgccaccat ttatagctca tgattgtagc tgaactgcaa aaactgcatc     1860

gattgcaaac tgaaattgag aatctctttt caactttata tgctgattga tgcatgctga     1920

gcatgctata ctagtactcg aagttcctat atgtagactt tgttactgcc taatatactt     1980

tgtgtttgtt ctcaagttct tattttattt catatttttt cctataaaag gttaatggct     2040

ctataaaggt tgagtgacat atatatacta taaaggttct tcctctctct ccggtttg       2098


<210>  333
<211>  1202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD43 HR1-SAMS PCR PCR amplicon

<400>  333
gtgtagtcca ttgtagccaa gtcaccaata tcttgttccc ctccttggtt tggcataaat       60

tgattttcat ggctcttctc ggtcgaaact ggagctaatt cacccttagt ctctcttaaa      120

attctggctg taagaaacac cacagaacac ataaattata aactaattat aatttgaaga      180

gtaaaatatg tttttactct tatgatttaa ttagtgtagt tttaattttc tccttttttt      240

aaaaaatttt ggtattcata aatttcaatt ttttaaaaat aattgttgtt acccgttaat      300

gataacggga tatgttatgt taccactaaa tcggacaaaa aaaattcaaa acttttataa      360

ggattaaaat taacaaaaat attttaaaaa aatctaacct caataaagtt aaatttataa      420

gcacaaaata atacttttaa gcctaatttg gcaagacaca agcaagctca cctgtagcat      480

taatagaaag gaagcaaagc aagagaaaag caaccagaag gaagcgtttg cttggtgaca      540

cagccatctt acttgaattt atggtattac tgagaaacct tgatcttgct tcaaaatctt      600

ctagttaccc tctttttata ggcagaaaga gaactagcta gttgccaata ggatatgagg      660

acatgtggtg caatgcactc actcttcaag gacaagaaaa acaatggcta caattgtggt      720

tcaaatcaat gtctcctgct ctgtcctgcc tgaaaatgac acccttttgc ttggaaaaga      780

ggatcaaagc taagaacagg agtggcttca ttcccttcat gtaaccaaac actttcgcat      840

tctgtcattc gtgaatcagc aaaatctgca accaaaaata tatggtgcct aaataaaaga      900

aataaaataa tttagagttg cggactaaaa taataaacaa aagaaatata ttataatcta      960

gaattaattt aggactaaaa gaagaggcag actccaattc ctcttttcta gaataccctc     1020

cgtacgtaca ctagtggtca cctaagtgac tagggtcacg tgaccctagt cacttattcc     1080

caaacactag taacggccgc cagtgtgctg gaattcgccc ttcccaagct ttgctctaga     1140

tcaaactcac atccaaacat aacatggata tcttccttac caatcatact aattattttg     1200

gg                                                                    1202


<210>  334
<211>  1454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DD43 NOS-HR2 PCR PCR amplicon

<400>  334
ggaacttcac tagagcttgc ggccgcgcat gctgacttaa tcagctaacg ccactcgacc       60

tgcaggcatg cccgcggata tcgatgggcc ccggccgaag cttcaagttt gtacaaaaaa      120

gcaggctggc gccggaacca attcagtcga ctggatccgg taccgaattc gcggccgcac      180

tcgagatatc tagacccagc tttcttgtac aaagtggccg ttaacggatc ggccagaatc      240

cggtaagtga ctagggtcac gtgaccctag tcacttaaat tcggccagaa tggccatctg      300

gattcagcag gcctagaagg cccggaccga ttaaacttta attcggtccg ggttacctct      360

agaaagcttg tcgacctgca ggtacaagta caagggactt gtgagttgta aggctgtatt      420

tacaatagtg aaaagagaat catctgggtg attgggtttt tagtccccag tgacgaatta      480

aaggtttgaa ttcttagtat gtttgggaat caattaggaa tttcgttttg gactttccaa      540

agcaattatt cactttttca ttcattaaat gtgactaaaa aattgttatt tctccattgg      600

ccaggatgca tcgtttatat aaacataacc ttagtgaaag cagtgttttc atgtgacagc      660

ggcagactat atcttaaaca aaattacttg taaagaaaga taccgttagg aaaaaaatga      720

aaagaaaatt gaagctatca cttgtttact ttcctaatat ctttcaagaa tacaatgtgg      780

tgaatttcaa ttttccctac atatgtatac cgtcagcctg acgcaactta tgaaacttct      840

ctttctttca tttgatgtat atataaagac acattatata taaagaaact ttatatatat      900

ctccatcata ttttagtact tgctactatg taaaattagc tgttggaagt atctcaagaa      960

acatttaatt tattgaacca agcattaacc attcatctac atttgagttc taaaataaat     1020

cttaaatgat gtggaggaag ggaaattgtt aattatttcc ctcttctcct acatggatat     1080

acctgaaaca tgcaatggat ggattagatt ttaacatttg cagcctgaga agttcactga     1140

ctttcctcca gctattttat gtgtgcccgc caccatttat agctcatgat tgtagctgaa     1200

ctgcaaaaac tgcatcgatt gcaaactgaa attgagaatc tcttttcaac tttatatgct     1260

gattgatgca tgctgagcat gctatactag tactcgaagt tcctatatgt agactttgtt     1320

actgcctaat atactttgtg tttgttctca agttcttatt ttatttcata ttttttccta     1380

taaaaggtta atggctctat aaaggttgag tgacatatat atactataaa ggttcttcct     1440

ctctctccgg tttg                                                       1454


<210>  335
<211>  60
<212>  DNA
<213>  Glycine max


<220>
<221>  soybean genomic DD20CR1 target region
<222>  (1)..(60)

<400>  335
acttgtactt atcaaaattc ggaactgaca cacgacatga tggaacgtga ctaaggtggg       60


<210>  336
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  336
acttgtactt atcaaaattc ggaactgaca cacgactgat ggaacgtgac taaggtggg        59


<210>  337
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  337
acttgtactt atcaaaattc ggaactgaca cacgaatgat ggaacgtgac taaggtggg        59


<210>  338
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  338
acttgtactt atcaaaattc ggaactgaca cacgatgatg gaacgtgact aaggtggg         58


<210>  339
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  339
acttgtactt atcaaaattc ggaactgaca cacgacgatg gaacgtgact aaggtggg         58


<210>  340
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  340
acttgtactt atcaaaattc ggaactgaca cacggtgatg gaacgtgact aaggtggg         58


<210>  341
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  341
acttgtactt atcaaaattc ggaactgaca cacatgatgg aacgtgacta aggtggg          57


<210>  342
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  342
acttgtactt atcaaaattc ggaactgaca cacgtgatgg aacgtgacta aggtggg          57


<210>  343
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  343
acttgtactt atcaaaattc ggaactgaca cactgatgga acgtgactaa ggtggg           56


<210>  344
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  344
acttgtactt atcaaaattc ggaactgaca cacggatgga acgtgactaa ggtggg           56


<210>  345
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  345
acttgtactt atcaaaattc ggaactgaca cacgatggaa cgtgactaag gtggg            55


<210>  346
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  346
acttgtactt atcaaaattc ggaactgaca catgatggaa cgtgactaag gtggg            55


<210>  347
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  347
acttgtactt atcaaaattc ggaactgaca cacatggaac gtgactaagg tggg             54


<210>  348
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  348
acttgtactt atcaaaattc ggaactgaca ctgatggaac gtgactaagg tggg             54


<210>  349
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  349
acttgtactt atcaaaattc ggaactgaca cgatggaacg tgactaaggt ggg              53


<210>  350
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  350
acttgtactt atcaaaattc ggaactgatg atggaacgtg actaaggtgg g                51


<210>  351
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  351
acttgtactt atcaaaattc ggaactgaca tggaacgtga ctaaggtggg                  50


<210>  352
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  352
acttgtactt atcaaaattc ggaactgtga tggaacgtga ctaaggtggg                  50


<210>  353
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  353
acttgtactt atcaaaattc ggaactgaca cacgaacgtg actaaggtgg g                51


<210>  354
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  354
acttgtactt atcaaaattc ggaactgaca cggaacgtga ctaaggtggg                  50


<210>  355
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  355
acttgtacct atcaaaattc ggaactgaat ggaacgtgac taaggtggg                   49


<210>  356
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  356
acttgtactt atcaaaattc ggaactgatg gaacgtgact aaggtggg                    48


<210>  357
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  357
acttgtactt atcaaaattc ggaactgaga acgtgactaa ggtggg                      46


<210>  358
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  358
acttgtactt atcaaaattc ggaactgaca cacgacat                               38


<210>  359
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  359
acttgtactt atcaaaattc ggaactgaca aaggtggg                               38


<210>  360
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  360
acttgtactt atcaaaattc ggaacgtgac taaggtggg                              39


<210>  361
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  361
actatggaac gtgactaagg tggg                                              24


<210>  362
<211>  211
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  362
acttgtactt atcaaaattc ggaactgaca cacggccggt gatggattgg tggatgagtg       60

ttgcgtcgag cacctccttg gtggaggtgt atctcttcct gtcaatggtg gtgtcgaagt      120

acttgaaggc agcaggggct cccaagtttg tgagggtaaa caggtggata atgttttcag      180

cctgctcgcg atggaacgtg actaaggtgg g                                     211


<210>  363
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  363
acttgtactt atcaaaaact acttgtgctg taaaaaaaaa gaggaacaat cttcactcat       60

caataagtga tggaacgcga ctaaggtggg                                        90


<210>  364
<211>  57
<212>  DNA
<213>  Glycine max


<220>
<221>  soybean genomic DD20CR2 target region
<222>  (1)..(57)

<400>  364
gacacacgac atgatggaac gtgactaagg tgggtttttg actttgcatg tcgaagt          57


<210>  365
<211>  61
<212>  DNA
<213>  artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  365
actgacacac gacatgatgg aacgtgaact aaggtgggtt tttgactttg catgtcgaag       60

t                                                                       61


<210>  366
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  366
actgacacac gacatgatgg aacgtactaa ggtgggtttt tgactttgca tgtcgaagt        59


<210>  367
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  367
actgacacac gacatgatgg aacgtctaag gtgggttttt gactttgcat gtcgaagt         58


<210>  368
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  368
actgacacac gacatgatgg aacgtgaaag gtgggttttt gactttgcat gtcgaagt         58


<210>  369
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  369
actgacacac gacatgatgg aacgctaagg tgggtttttg actttgcatg tcgaagt          57


<210>  370
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  370
actgacacac gacatgatgg aacgtgaagg tgggtttttg actttgcatg tcgaagt          57


<210>  371
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  371
actgacacac gacatgatgg aacgtgaggt gggtttttga ctttgcatgt cgaagt           56


<210>  372
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  372
actgacacac gacatgatgg aacgtaaggt gggtttttga ctttgcatgt cgaagt           56


<210>  373
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  373
actgacacac gacatgatgg aacctaaggt gggtttttga ctttgcatgt cgaagt           56


<210>  374
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  374
actgacacac gacatgatgg aacgtgaggt gggtttttga ctttgcatgt cgaagt           56


<210>  375
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  375
actgacacac gacatgatgg aactaaggtg ggtttttgac tttgcatgtc gaagt            55


<210>  376
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  376
actgacacac gacatgatgg aataaggtgg gtttttgact ttgcatgtcg aagt             54


<210>  377
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  377
actgacacac gacatgatgg ctaaggtggg tttttgactt tgcatgtcga agt              53


<210>  378
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  378
actgacacac gacatgatgg ataaggtggg tttttgactt tgcatgtcga agt              53


<210>  379
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  379
actgacacac gacatgatgg aaggtgggtt tttgactttg catgtcgaag t                51


<210>  380
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  380
actgacacac gacatgatgg aggtgggttt ttgactttgc atgtcgaagt                  50


<210>  381
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  381
actgacacac gacatgatgg gtttttgact ttgcatgtcg aagt                        44


<210>  382
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  382
actgacacac gacaggtggg tttttgactt tgcatgtcga agt                         43


<210>  383
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  383
actgacacta aggtgggttt ttgactttgc atgtcgaagt                             40


<210>  384
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  384
actgacacac gacatgatgg aacgt                                             25


<210>  385
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  385
actgacacac gacatgatgg                                                   20


<210>  386
<211>  60
<212>  DNA
<213>  Glycine max


<220>
<221>  soybean genomic DD43CR1 target region
<222>  (1)..(60)

<400>  386
agccttacaa ctcacaagtc ccttgtactt gtacgtacgg agggtattct agaaaagagg       60


<210>  387
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  387
agccttacaa ctcacaagtc ccttgtactt gtactacgga gggtattcta gaaaagagg        59


<210>  388
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  388
agccttacaa ctcacaagtc ccttgtactt gtagtacgga gggtattcta gaaaagagg        59


<210>  389
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  389
agccttacaa ctcacaagtc ccttgtactt gtgtacggag ggtattctag aaaagagg         58


<210>  390
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  390
agccttacaa ctcacaagtc ccttgtactt gcgtacggag ggtattctag aaaagagg         58


<210>  391
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  391
agccttacaa ctcacaagtc ccttgtactt ggtacggagg gtattctaga aaagagg          57


<210>  392
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  392
agccttacaa ctcacaagtc ccttgtactt gttacggagg gtattctaga aaagagg          57


<210>  393
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  393
agccttacaa ctcacaagtc ccttgtactt gtacggaggg tattctagaa aagagg           56


<210>  394
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  394
agccttacaa ctcacaagtc ccttgtactt tacggagggt attctagaaa agagg            55


<210>  395
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  395
agccttacaa ctcacaagtc ccttgtactg tacggagggt attctagaaa agagg            55


<210>  396
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  396
agccttacaa ctcacaagcc ccttgtactt acggagggta ttctagaaaa gagg             54


<210>  397
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  397
agccttacaa ctcacaagtc ccttgtatac ggagggtatt ctagaaaaga gg               52


<210>  398
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  398
agccttacaa ctcacaagtc ccttgtgtac ggagggtatt ctagaaaaga gg               52


<210>  399
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  399
agccttacaa ctcacaagtc ccttgtacgg agggtattct agaaaagagg                  50


<210>  400
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  400
agccttacaa ctcacaagtc cctttacgga gggtattcta gaaaagagg                   49


<210>  401
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  401
agccttacaa ctcacaagtc ccttacggag ggtattctag aaaagagg                    48


<210>  402
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  402
agccttacaa ctcacaagtc cctacggagg gtattctaga aaagagg                     47


<210>  403
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated NHEJ

<400>  403
agccttacaa ctcacaagtc ccttgtactt gtaagaaaag agg                         43


<210>  404
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  404
agccttacaa ctcacaagtc ctaaattaaa ggttattcta gaaaagagg                   49


<210>  405
<211>  227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  405
agccttacaa ctcacaagtc ccttgtactt gtagaatcca gttcataaaa caagtgacac       60

acaacagata tgaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa      120

atcgctcaaa ccacaaaaaa gaacaacgcg tttgttacac gctaatacca aaattatacc      180

caaatcttaa gctatttatg cgtacggagg gtattctaga aaagagg                    227


<210>  406
<211>  97
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  406
agccttacaa ctcacaagtc ccttgtactt gtaatgctcc cctctaaact cgtatcgctt       60

cagagttgag agtacggagg gtattctaga aaagagg                                97


<210>  407
<211>  183
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  407
agccttacaa ctcacaagtc ccttgtatat agatacccac aaaataagta aacccgatcc       60

aaaatcttaa atgatgtgga ggaagggaaa ttgttaatta ttcccctctt ctcctacatg      120

gatatacctg aaacatgcaa tggatggatt agattttgta cggagggtat tctagaaaag      180

agg                                                                    183


<210>  408
<211>  234
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  408
agccttacaa ctcacaagtc ccttgtactt gtaccagggg atgtttttta tttacattca       60

cgtcttttgg aaagagccgc taaattaagt tctcagttag gcgaaggaag tatgactgct      120

ttaccaatag ttgaaactca atcgggagat gtttcagctt atattcctac taatgtaatt      180

tccattacag atggccaaat attcttacgt acggagggta ttctagaaaa gagg            234


<210>  409
<211>  280
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  409
agccttacaa ctcacaagtc ccttgtactt gtaccgaaaa tttcagccat aaaaaaagtt       60

ataatagaat ttaaagcaaa agtttcattt tttaaacata tatactgaca cgctccgata      120

aaaatagagg caagtccgac aacgtcccct ccgaggaggt cgtgaagaag atgaaaaact      180

actggagaca gctcttgaac gccaagctca tcacccagcg taagctcgac aacctgacta      240

aggctgagag aggtgtacgg agggtattct agaaaagagg                            280


<210>  410
<211>  250
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  410
agccttacaa ctcacaagtc ccttgtactt gtactggatt tggtgaggga tgcttccgtt       60

gtcgaaggtt ctctgcttcc tcaacaggtc ctctctgttc aacttcacca acagctcctc      120

ggtaccgtcc atcttctcaa ggatgaagat cgagtgcttc gactccgtcg agatctctgg      180

tgtcgaggac aggttcaacg cctcccttgg gacttgccac gatcgtacgg agggtattct      240

agaaaagagg                                                             250


<210>  411
<211>  161
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  411
agccttacaa ctcacaagtc ccttatgacc tcaaaaaaaa gattcacctc caacacacca       60

aataactcga aaatctcttt cctattctct agaaagtata ggaacttcca ctagtccatg      120

aaaaagcctg aactcgtacg gagggtattc tagaaaagag g                          161


<210>  412
<211>  185
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  412
agccttacaa ctcacaagtc ccttgtactt gtacacctgg ggcatggaga gcaccttcct       60

cacagtagcg aaatccctcc ctttgtccca cacgatctct ccagtctcac cgttggtctc      120

gatcagtggg cgcttcctga tctcaccgtt ggcgagagtg tacggagggt attctagaaa      180

agagg                                                                  185


<210>  413
<211>  212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  413
agccttacaa ctcacaagtc ccttgtactt gtgctaggtt agccgaaaga tggttatcgg       60

ttcaaggacg caaggtgccc ctgctttttc agggtaataa ggggtagaga aaatgcctcg      120

agccaaagtt cgagtaccag gcgctacagc gctgaagtaa tccatgccat actcccagga      180

aaagccgtac ggagggtatt ctagaaaaga gg                                    212


<210>  414
<211>  231
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence of gRNA/Cas9 system mediated target site modification

<400>  414
agccttacaa ctcacaagtc ccttgtactt gtactcaagt tcttatttta tttcatattt       60

tttcctataa aaggttaatg gctctataaa ggttgagtga cggatccggt cacctaagtg      120

actagggtca cgtgacccta gtcacttatt cccgggcaac tttattatac aaagttgata      180

gatctcgaat tcattccgat taatcgtggc gagggtattc tagaaaagag g               231


<210>  415
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 1

<400>  415
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggtcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  416
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 2

<400>  416
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggacggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  417
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 3

<400>  417
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc gggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  418
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 4

<400>  418
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggccggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  419
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 5

<400>  419
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggatcggagg       60

atatatatac ctcacacgta cgcgtacgcg tatatatac                              99


<210>  420
<211>  94
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 6

<400>  420
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggaggatata       60

tatacctcac acgtacgcgt acgcgtatat atac                                   94


<210>  421
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 7

<400>  421
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggttcacacg       60

tacgcgtacg cgtatatata c                                                 81


<210>  422
<211>  65
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 8

<400>  422
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtacgcg tacgcgtata       60

tatac                                                                   65


<210>  423
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 9

<400>  423
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggttcggagg       60

atatatatac ctcacacgta cgcgtacgcg tatatatac                              99


<210>  424
<211>  95
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1 mutation 10

<400>  424
tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc cggaggatat       60

atatacctca cacgtacgcg tacgcgtata tatac                                  95


<210>  425
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 1

<400>  425
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgaccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  426
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 2

<400>  426
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgtccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  427
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 3

<400>  427
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtccccg gcggaggata       60

tatatacctc acacgtacgc gtacgcgtat atatac                                 96


<210>  428
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 4

<400>  428
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtggccc cggcggagga       60

tatatatacc tcacacgtac gcgtacgcgt atatatac                               98


<210>  429
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 5

<400>  429
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcacc ccggcggagg       60

atatatatac ctcacacgta cgcgtacgcg tatatatac                              99


<210>  430
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 6

<400>  430
gaagctgtaa cgatttacgc acctgctggg aattgtaccc ggcggaggat atatatacct       60

cacacgtacg cgtacgcgta tatatac                                           87


<210>  431
<211>  92
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 7

<400>  431
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tccccggcgg aggatatata       60

tacctcacac gtacgcgtac gcgtatatat ac                                     92


<210>  432
<211>  94
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 8

<400>  432
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacccccggc ggaggatata       60

tatacctcac acgtacgcgt acgcgtatat atac                                   94


<210>  433
<211>  95
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 9

<400>  433
gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgccccgg cggaggatat       60

atatacctca cacgtacgcg tacgcgtata tatac                                  95


<210>  434
<211>  88
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2 mutation 10

<400>  434
gaagctgtaa cgatttacgc acctgctggg aattgtaccc cggcggagga tatatatacc       60

tcacacgtac gcgtacgcgt atatatac                                          88


<210>  435
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 1

<400>  435
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtt gtgaggtata       60

tatatcctcc gccggggcac gtacggtaca attcccag                               98


<210>  436
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 2

<400>  436
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacggt gaggtatata       60

tatcctccgc cggggcacgt acggtacaat tcccag                                 96


<210>  437
<211>  95
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 3

<400>  437
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg aggtatatat       60

atcctccgcc ggggcacgta cggtacaatt cccag                                  95


<210>  438
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 4

<400>  438
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtactgt gaggtatata       60

tatcctccgc cggggcacgt acggtacaat tcccag                                 96


<210>  439
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 5

<400>  439
aaggcgcaaa tgagtagcag cgcacgtata tatatcctcc gccggggcac gtacggtaca       60

attcccag                                                                68


<210>  440
<211>  93
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 6

<400>  440
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtgtgag gtatatatat       60

cctccgccgg ggcacgtacg gtacaattcc cag                                    93


<210>  441
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 7

<400>  441
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgtgaggtat atatatcctc       60

cgccggggca cgtacggtac aattcccag                                         89


<210>  442
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 8

<400>  442
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtactat atatatcctc       60

cgccggggca cgtacggtac aattcccag                                         89


<210>  443
<211>  94
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 9

<400>  443
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgga ggtatatata       60

tcctccgccg gggcacgtac ggtacaattc ccag                                   94


<210>  444
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3 mutation 0

<400>  444
aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgat gaggtatata       60

tatcctccgc cggggcacgt acggtacaat tcccag                                 96


<210>  445
<211>  1051
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-1_crRNA_Expression_Cassette

<400>  445
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gtaccgtacg tgccccggcg     1020

ggttttagag ctatgctgtt ttgttttttt t                                    1051


<210>  446
<211>  1051
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-2_crRNA_Expression_Cassette

<400>  446
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt ggaattgtac cgtacgtgcc     1020

cgttttagag ctatgctgtt ttgttttttt t                                    1051


<210>  447
<211>  1047
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LIGCas-3_crRNA_Expression_Cassette

<400>  447
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcgtacgcgt acgtgtggtt     1020

ttagagctat gctgttttgt ttttttt                                         1047


<210>  448
<211>  1087
<212>  DNA
<213>  Artificial sequence

<220>
<223>   tracrRNA_Expression_Cassette

<400>  448
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt ggaaccattc aaaacagcat     1020

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct     1080

ttttttt                                                               1087


<210>  449
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-2 forward primer for primary

<400>  449
ctacactctt tccctacacg acgctcttcc gatctgaagc tgtaacgatt tacgcacctg       60

ctg                                                                     63


<210>  450
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGCas-3 forward primer for primary PCR

<400>  450
ctacactctt tccctacacg acgctcttcc gatctttccc gcaaatgagt agcagcgcac       60


<210>  451
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Zm-ARGOS8-CTS1, Cas9 target sequence 1

<400>  451
gcgtgcatcg atccatcgc                                                    19


<210>  452
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  m-ARGOS8-CTS2, Cas9 target sequence 2

<400>  452
ggctacggat agatatgatg c                                                 21


<210>  453
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Zm-ARGOS8-CTS3, Cas9 target sequence 3

<400>  453
gttacttctc taagcacggc                                                   20


<210>  454
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P1, Forward_primer

<400>  454
gcgccattcc ctaaaggtaa c                                                 21


<210>  455
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P2, Reverse_primer

<400>  455
gctaatcgta agtgacgctt gga                                               23


<210>  456
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P3, Forward_primer

<400>  456
gctcgtgtcc aagcgtcact tacgattagc t                                      31


<210>  457
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4, Reverse_primer

<400>  457
ctgcgaactg cttgattccg                                                   20


<210>  458
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P5, Forward_primer

<400>  458
accgtcctta tctctgcatc atct                                              24


<210>  459
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PBS, Primer Binding Site

<400>  459
gctcgtgtcc aagcgtcact tacgattagc t                                      31


<210>  460
<211>  1823
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(1823)
<223>  Zm-GOS2 PRO-GOS2 INTRON, maize GOS2 promoter and GOS2 intron1 
       including the promoter, 


5'-UTR1, INTRON1 and 5'-UTR2 sequence

<400>  460
taattattgg ctgtaggatt ctaaacagag cctaaatagc tggaatagct ctagccctca       60

atccaaacta atgatatcta tacttatgca actctaaatt tttattctaa aagtaatatt      120

tcatttttgt caacgagatt ctctactcta ttccacaatc ttttgaagct atatttacct      180

taaatctgta ctctatacca ataatcatat attctattat ttatttttat ctctctccta      240

aggagcatcc ctctatgtct gcatggcccc cgcctcgggt cccaatctct tgctctgcta      300

gtagcacaga agaaaacact agaaatgact tgcttgactt agagtatcag ataaacatca      360

tgtttactta actttaattt gtatcggttt ctactatttt tataatattt ttgtctctat      420

agatactacg tgcaacagta taatcaacct agtttaatcc agagcgaagg attttttact      480

aagtacgtga ctccatatgc acagcgttcc ttttatggtt cctcactggg cacagcataa      540

acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa ttccatcagc gaacaaacaa      600

catacatgcg agatgaaaat aaataataaa aaaagctccg tctcgatagg ccggcacgaa      660

tcgagagcct ccatagccag ttttttccat cggaacggcg gttcgcgcac ctaattatat      720

gcaccacacg cctataaagc caaccaaccc gtcggagggg cgcaagccag acagaagaca      780

gcccgtcagc ccctctcgtt tttcatccgc cttcgcctcc aaccgcgtgc gctccacgcc      840

tcctccagga aagcgagagg tgagcgcagt cccctttccc ctccttccaa ttcaattcgt      900

cttctcgttc gcagccctag gatttggggg tctggagggg tttgatcgtt tctcgccgtg      960

aatctgcttt ggtgtaaacc aacggatctc ggatcgtagt cttcagaaga tcccggattt     1020

tgcggtttgg cccctcctgg attcaattcg tcgtatcgtt cgcagcccta ggatttgggg     1080

atctggaggg gtttgatcgt ttctcgccgc gaatctgctc tggtgtaaac caacggatct     1140

cgggtcgtag tcttcagaag gtcccggatt ttgcggtttg gcccctcctg gattcaattc     1200

gtcgtatcgt tcgcagccct aggatttggg gatctggagg ggtttgatcc tttctcgccg     1260

cgaatctgct ctggtataac caacggatct cgggtcgtag tcttcagaag gtcccggatt     1320

ttgcggtttg gtggttcttg ctctatgaat cagagggatg gttcttcccg gatttatgcc     1380

ttgcggccac tctgtcgaat catggggttt cgacccgatt cgtaggcgtg ctccctgttt     1440

tggatgggaa gtaggcgtgt ttgtagtatt cgtgcttcga ttcgtcaacg gagattagaa     1500

gacctgggat gggatttgag gaaatctagg tatctgtcta gcacgtttct agatctattc     1560

ttcagctgtt atatgagagt aattttggaa ccctggtggg gtatgtttga ccgagtattc     1620

tgtagattat tgtccgtgac ttgctggctg ttaccgtcct tatctctgca tcatctatct     1680

gtgctagttt ctgcgtgctt ctcaaatatt tccggcctgt gtagcatgtg actgataata     1740

tgattttggc agcttctgca taagaacaac aaatcaaaag cttgatcagc tcggtgccta     1800

caaaacctca acaaccaagt ttc                                             1823


<210>  461
<211>  556
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(556)
<223>  Zm-ARGOS8 promoter

<400>  461
gttacttctc taagcacggc tggatttcag gcctctagtc ctctactagt actagctaca       60

cgacgtgcac gcatgcatca cagcatcaac aactagacac gcacacgctg cacgcggccg      120

gggaacccac tgattccccc cttccccgcg cgcggtttga tttcctttcc tggtacggat      180

ccatatctga gggcttgttc ggttattccc aacacacatg tattggatgg gattgaaaaa      240

aaaatgagaa gaagtttgac ttgtttggga ttcaaaccca tccaatccca ctcaatccac      300

atggattgag agctaaccga acaagccctc atagtacata cctggtacgg atccatatca      360

tagtacatag atccagtaga atagaaggtg atccgaccgc cggcgcttgc gttgttttcc      420

ccggtccatt gaacctgcca accctcctaa ccacaggcac gccaaaccgc gggctccggc      480

caccaccgcc accgccacct gccctgccgc acctctccaa ccccaaatcc aggggggggg      540

gggggcacca tgcgtg                                                      556


<210>  462
<211>  155
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(155)
<223>  Zm-ARGOS8 5'-UTR

<400>  462
catcgatcca tcgctggcgc gcgggtccgg cggggcggtc tgtgagggca aatttatata       60

ggtctagtgg gtacccggct acggatagat atgatgctgc actgcacatt ggctatatct      120

gaggctcctg cgcgcgcctt ggccaggtgt ctgtc                                 155


<210>  463
<211>  285
<212>  DNA
<213>  Zea mays

<400>  463
atgcgggcga tgccgcagga agaggaagcc gcggtggcga cgacgaccat ggccgggggc       60

aaggtggcgg cgctgctggc cacggcggcc gcgctgctgc tgctgctccc gctggcgctg      120

ccgccgctgc cgccgccgcc cacgcagctg ttgttcgtcc ccgtggtctt gctgctcctc      180

gtggcgtccc tcgcgttctg ccccgccgcg accccctcgc cgtcgccgat gcatgccgcc      240

gaccacgggt cgttcgggac cactggatca ccgcacctat gttga                      285


<210>  464
<211>  2843
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(2843)
<223>  Zm-GOS2 gene, including promoter, 5'-UTR, CDS, 3'-UTR and introns
       sequence

<400>  464
taattattgg ctgtaggatt ctaaacagag cctaaatagc tggaatagct ctagccctca       60

atccaaacta atgatatcta tacttatgca actctaaatt tttattctaa aagtaatatt      120

tcatttttgt caacgagatt ctctactcta ttccacaatc ttttgaagct atatttacct      180

taaatctgta ctctatacca ataatcatat attctattat ttatttttat ctctctccta      240

aggagcatcc ctctatgtct gcatggcccc cgcctcgggt cccaatctct tgctctgcta      300

gtagcacaga agaaaacact agaaatgact tgcttgactt agagtatcag ataaacatca      360

tgtttactta actttaattt gtatcggttt ctactatttt tataatattt ttgtctctat      420

agatactacg tgcaacagta taatcaacct agtttaatcc agagcgaagg attttttact      480

aagtacgtga ctccatatgc acagcgttcc ttttatggtt cctcactggg cacagcataa      540

acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa ttccatcagc gaacaaacaa      600

catacatgcg agatgaaaat aaataataaa aaaagctccg tctcgatagg ccggcacgaa      660

tcgagagcct ccatagccag ttttttccat cggaacggcg gttcgcgcac ctaattatat      720

gcaccacacg cctataaagc caaccaaccc gtcggagggg cgcaagccag acagaagaca      780

gcccgtcagc ccctctcgtt tttcatccgc cttcgcctcc aaccgcgtgc gctccacgcc      840

tcctccagga aagcgagagg tgagcgcagt cccctttccc ctccttccaa ttcaattcgt      900

cttctcgttc gcagccctag gatttggggg tctggagggg tttgatcgtt tctcgccgtg      960

aatctgcttt ggtgtaaacc aacggatctc ggatcgtagt cttcagaaga tcccggattt     1020

tgcggtttgg cccctcctgg attcaattcg tcgtatcgtt cgcagcccta ggatttgggg     1080

atctggaggg gtttgatcgt ttctcgccgc gaatctgctc tggtgtaaac caacggatct     1140

cgggtcgtag tcttcagaag gtcccggatt ttgcggtttg gcccctcctg gattcaattc     1200

gtcgtatcgt tcgcagccct aggatttggg gatctggagg ggtttgatcc tttctcgccg     1260

cgaatctgct ctggtataac caacggatct cgggtcgtag tcttcagaag gtcccggatt     1320

ttgcggtttg gtggttcttg ctctatgaat cagagggatg gttcttcccg gatttatgcc     1380

ttgcggccac tctgtcgaat catggggttt cgacccgatt cgtaggcgtg ctccctgttt     1440

tggatgggaa gtaggcgtgt ttgtagtatt cgtgcttcga ttcgtcaacg gagattagaa     1500

gacctgggat gggatttgag gaaatctagg tatctgtcta gcacgtttct agatctattc     1560

ttcagctgtt atatgagagt aattttggaa ccctggtggg gtatgtttga ccgagtattc     1620

tgtagattat tgtccgtgac ttgctggctg ttaccgtcct tatctctgca tcatctatct     1680

gtgctagttt ctgcgtgctt ctcaaatatt tccggcctgt gtagcatgtg actgataata     1740

tgattttggc agcttctgca taagaacaac aaatcaaaag cttgatcagc tcggtgccta     1800

caaaacctca acaaccaagt ttcatgtctg atctcgacgt ccagcttcca tctgcctttg     1860

gtatggctac ttctcaattc atgatgccat gttttttttt atattgtggt tttacataat     1920

acatagcatc ttccagcttc ctgaagagta ttactgaata gattgataac atcatacaca     1980

cgaagttcat cttgaacatg cttattagtg ttctgtttgc atctgatggt atggcatcat     2040

ctttgataga tccgtttgct gaggcaaatg ctgaggactc tggtgctggt cctggaacga     2100

aggattatgt gcatgtgcgc atccagcagc gcaacggcag aaagagtctg actacagtcc     2160

agggtctgaa gaaagagttc agctataaca agatcctcaa ggatctgaag aaggaattct     2220

gctgcaatgg tactgtagtt caggacccag agctaggcca ggtaagatac gagaacaatg     2280

catttcaagc ttgtaaaaat ggtatctgcc ggttggtgga tatactgatc tgtttgtccg     2340

ctgcaggtca ttcagctcca aggtgaccag cgcaagaatg ttgctacttt cctagttcag     2400

gtattcagaa tcttcagacc tggccagctg aatactgttt taccataccg atagatgttc     2460

aatctgttaa tactgatcgt gcaattatta cttgtcttgg taggctggga ttgcgaagaa     2520

agagaacatc aagattcacg ggttctaagg gacctgtaaa tgcttgtgcc ctatattgtg     2580

tgcctccaca tattggggag cttgaagcat cgacagttac tagtcattgc ttacttatat     2640

aagaacataa gtagtatttg ctattgtcaa gtgtgccttg cttgatgcaa gttgtgtttt     2700

cgtatcatta ttattatgca cggccatcgt acgtgtatgg cttgtatggg ttattgccaa     2760

cttaataaaa gcacactctg tttgcctata agcactgatg tttgcctcgt catgcacatg     2820

ttgagtcggg ttttatttgt att                                             2843


<210>  465
<211>  800
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(800)
<223>  Zm-GOS2 PRO, maize GOS2 promoter

<400>  465
taattattgg ctgtaggatt ctaaacagag cctaaatagc tggaatagct ctagccctca       60

atccaaacta atgatatcta tacttatgca actctaaatt tttattctaa aagtaatatt      120

tcatttttgt caacgagatt ctctactcta ttccacaatc ttttgaagct atatttacct      180

taaatctgta ctctatacca ataatcatat attctattat ttatttttat ctctctccta      240

aggagcatcc ctctatgtct gcatggcccc cgcctcgggt cccaatctct tgctctgcta      300

gtagcacaga agaaaacact agaaatgact tgcttgactt agagtatcag ataaacatca      360

tgtttactta actttaattt gtatcggttt ctactatttt tataatattt ttgtctctat      420

agatactacg tgcaacagta taatcaacct agtttaatcc agagcgaagg attttttact      480

aagtacgtga ctccatatgc acagcgttcc ttttatggtt cctcactggg cacagcataa      540

acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa ttccatcagc gaacaaacaa      600

catacatgcg agatgaaaat aaataataaa aaaagctccg tctcgatagg ccggcacgaa      660

tcgagagcct ccatagccag ttttttccat cggaacggcg gttcgcgcac ctaattatat      720

gcaccacacg cctataaagc caaccaaccc gtcggagggg cgcaagccag acagaagaca      780

gcccgtcagc ccctctcgtt                                                  800


<210>  466
<211>  1023
<212>  DNA
<213>  Zea mays


<220>
<221>  misc_feature
<222>  (1)..(1023)
<223>  GOS2 INTRON, maize GOS2 5'-UTR1 and intron1 and 5'-UTR2 sequence

<400>  466
tttcatccgc cttcgcctcc aaccgcgtgc gctccacgcc tcctccagga aagcgagagg       60

tgagcgcagt cccctttccc ctccttccaa ttcaattcgt cttctcgttc gcagccctag      120

gatttggggg tctggagggg tttgatcgtt tctcgccgtg aatctgcttt ggtgtaaacc      180

aacggatctc ggatcgtagt cttcagaaga tcccggattt tgcggtttgg cccctcctgg      240

attcaattcg tcgtatcgtt cgcagcccta ggatttgggg atctggaggg gtttgatcgt      300

ttctcgccgc gaatctgctc tggtgtaaac caacggatct cgggtcgtag tcttcagaag      360

gtcccggatt ttgcggtttg gcccctcctg gattcaattc gtcgtatcgt tcgcagccct      420

aggatttggg gatctggagg ggtttgatcc tttctcgccg cgaatctgct ctggtataac      480

caacggatct cgggtcgtag tcttcagaag gtcccggatt ttgcggtttg gtggttcttg      540

ctctatgaat cagagggatg gttcttcccg gatttatgcc ttgcggccac tctgtcgaat      600

catggggttt cgacccgatt cgtaggcgtg ctccctgttt tggatgggaa gtaggcgtgt      660

ttgtagtatt cgtgcttcga ttcgtcaacg gagattagaa gacctgggat gggatttgag      720

gaaatctagg tatctgtcta gcacgtttct agatctattc ttcagctgtt atatgagagt      780

aattttggaa ccctggtggg gtatgtttga ccgagtattc tgtagattat tgtccgtgac      840

ttgctggctg ttaccgtcct tatctctgca tcatctatct gtgctagttt ctgcgtgctt      900

ctcaaatatt tccggcctgt gtagcatgtg actgataata tgattttggc agcttctgca      960

taagaacaac aaatcaaaag cttgatcagc tcggtgccta caaaacctca acaaccaagt     1020

ttc                                                                   1023


<210>  467
<211>  23
<212>  DNA
<213>  Glycine max

<400>  467
gcgtcctttg acagcagctg tgg                                               23


<210>  468
<211>  23
<212>  DNA
<213>  Glycine max

<400>  468
gcaaccacag ctgctgtcaa agg                                               23


<210>  469
<211>  434
<212>  DNA
<213>  Glycine max

<400>  469
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaa                                                        434


<210>  470
<211>  9093
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC878

<400>  470
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg cgtcctttga cagcagctgg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggacaa aaagtactca atagggctcg acatagggac     2100

taactccgtt ggatgggccg tcatcaccga cgagtacaag gtgccctcca agaagttcaa     2160

ggtgttggga aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt     2220

cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac     2280

cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga tggccaaggt     2340

ggacgactcc ttcttccacc gccttgagga atcattcctg gtggaggagg ataaaaagca     2400

cgagagacac ccaatcttcg ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc     2460

taccatctac cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt     2520

gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga     2580

cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc agacctacaa     2640

ccagcttttc gaggagaacc caatcaacgc cagtggagtt gacgccaagg ctatcctctc     2700

tgctcgtctg tcaaagtcca ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa     2760

gaagaacgga ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa     2820

gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga     2880

tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct tcctcgccgc     2940

taagaacttg tccgacgcaa tcctgctgtc cgacatcctg agagtcaaca ctgagattac     3000

caaagctcct ctgtctgctt ccatgattaa gcgctacgac gagcaccacc aagatctgac     3060

cctgctcaag gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga     3120

ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta     3180

caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt tggtgaagtt     3240

gaacagagag gacctgttga ggaagcagag aaccttcgac aacggaagca tccctcacca     3300

aatccacctg ggagagctcc acgccatctt gaggaggcag gaggatttct atcccttcct     3360

gaaggacaac cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg     3420

gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat     3480

tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt ctttcatcga     3540

gaggatgacc aacttcgata aaaatctgcc caacgagaag gtgctgccca agcactccct     3600

gttgtacgag tatttcacag tgtacaacga gctcaccaag gtgaagtacg tcacagaggg     3660

aatgaggaag cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt     3720

caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga     3780

gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct cccttgggac     3840

ttaccacgat ctgctcaaga ttattaaaga caaggacttc ctggacaacg aggagaacga     3900

ggacatcctt gaggacatcg tgctcaccct gaccttgttc gaagacaggg aaatgatcga     3960

agagaggctc aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag     4020

acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa     4080

gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca acaggaactt     4140

catgcagctc attcacgacg actccttgac cttcaaggag gacatccaga aggctcaggt     4200

gtctggacag ggtgactcct tgcatgagca cattgctaac ttggccggct ctcccgctat     4260

taagaagggc attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg     4320

ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg     4380

gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag agcttggctc     4440

tcagatcctc aaggagcacc ccgtcgagaa cactcagctg cagaacgaga agctgtacct     4500

gtactacctc caaaacggaa gggacatgta cgtggaccag gagctggaca tcaacaggtt     4560

gtccgactac gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga     4620

caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga     4680

ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca agctcatcac     4740

ccagcgtaag ttcgacaacc tgactaaggc tgagagagga ggattgtccg agctcgataa     4800

ggccggattc atcaagagac agctcgtcga aacccgccaa attaccaagc acgtggccca     4860

aattctggat tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt     4920

caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta     4980

caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca acgctgtcgt     5040

tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct gagttcgtct acggcgacta     5100

caaggtgtac gacgtgagga agatgatcgc taagtctgag caggagatcg gcaaggccac     5160

cgccaagtac ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc     5220

caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt     5280

gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa     5340

catcgtcaag aagaccgaag ttcagaccgg aggattctcc aaggagtcca tcctccccaa     5400

gagaaactcc gacaagctga tcgctagaaa gaaagactgg gaccctaaga agtacggagg     5460

cttcgattct cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa     5520

gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc     5580

cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg tgaagaagga     5640

cctcatcatc aagctgccca agtactccct cttcgagttg gagaacggaa ggaagaggat     5700

gctggcttct gccggagagt tgcagaaggg aaatgagctc gcccttccct ccaagtacgt     5760

gaacttcctg tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga     5820

gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat     5880

ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg tgctgtccgc     5940

ctacaacaag cacagggata agcccattcg cgagcaggct gaaaacatta tccacctgtt     6000

taccctcaca aacttgggag cccctgctgc cttcaagtac ttcgacacca ccattgacag     6060

gaagagatac acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac     6120

cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc     6180

caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga ttggccaact     6240

taattaatgt atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg     6300

gcatcaaagt tgtgtgttat gtgtaattac tagttatctg aataaaagag aaagagatca     6360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat     6420

gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat taatatcaat     6480

tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc aagcttatcg     6540

ataccgtcga gggggggccc ggtaccggcg cgccgttcta tagtgtcacc taaatcgtat     6600

gtgtatgata cataaggtta tgtattaatt gtagccgcgt tctaacgaca atatgtccat     6660

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     6720

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6780

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6840

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgaccaaaat     6900

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6960

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     7020

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     7080

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     7140

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     7200

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     7260

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     7320

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     7380

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     7440

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     7500

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     7560

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     7620

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     7680

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     7740

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcaggt tgatcagatc     7800

tcgatcccgc gaaattaata cgactcacta tagggagacc acaacggttt ccctctagaa     7860

ataattttgt ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga     7920

cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct     7980

cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga tatgtcctgc     8040

gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg cactttgcat     8100

cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag agcctgacct     8160

attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc     8220

ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc     8280

agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact acatggcgtg     8340

atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg atggacgaca     8400

ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc gaggactgcc     8460

ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg     8520

gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg     8580

tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag acgcgctact     8640

tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat atgctccgca     8700

ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat gcagcttggg     8760

cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa     8820

tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg     8880

gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca gcttggatcg     8940

atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat     9000

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag     9060

gaactatatc cggatgatcg ggcgcgccgg tac                                  9093


<210>  471
<211>  9093
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC879

<400>  471
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg caaccacagc tgctgtcaag ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggacaa aaagtactca atagggctcg acatagggac     2100

taactccgtt ggatgggccg tcatcaccga cgagtacaag gtgccctcca agaagttcaa     2160

ggtgttggga aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt     2220

cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac     2280

cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga tggccaaggt     2340

ggacgactcc ttcttccacc gccttgagga atcattcctg gtggaggagg ataaaaagca     2400

cgagagacac ccaatcttcg ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc     2460

taccatctac cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt     2520

gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga     2580

cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc agacctacaa     2640

ccagcttttc gaggagaacc caatcaacgc cagtggagtt gacgccaagg ctatcctctc     2700

tgctcgtctg tcaaagtcca ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa     2760

gaagaacgga ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa     2820

gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga     2880

tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct tcctcgccgc     2940

taagaacttg tccgacgcaa tcctgctgtc cgacatcctg agagtcaaca ctgagattac     3000

caaagctcct ctgtctgctt ccatgattaa gcgctacgac gagcaccacc aagatctgac     3060

cctgctcaag gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga     3120

ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta     3180

caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt tggtgaagtt     3240

gaacagagag gacctgttga ggaagcagag aaccttcgac aacggaagca tccctcacca     3300

aatccacctg ggagagctcc acgccatctt gaggaggcag gaggatttct atcccttcct     3360

gaaggacaac cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg     3420

gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat     3480

tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt ctttcatcga     3540

gaggatgacc aacttcgata aaaatctgcc caacgagaag gtgctgccca agcactccct     3600

gttgtacgag tatttcacag tgtacaacga gctcaccaag gtgaagtacg tcacagaggg     3660

aatgaggaag cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt     3720

caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga     3780

gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct cccttgggac     3840

ttaccacgat ctgctcaaga ttattaaaga caaggacttc ctggacaacg aggagaacga     3900

ggacatcctt gaggacatcg tgctcaccct gaccttgttc gaagacaggg aaatgatcga     3960

agagaggctc aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag     4020

acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa     4080

gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca acaggaactt     4140

catgcagctc attcacgacg actccttgac cttcaaggag gacatccaga aggctcaggt     4200

gtctggacag ggtgactcct tgcatgagca cattgctaac ttggccggct ctcccgctat     4260

taagaagggc attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg     4320

ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg     4380

gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag agcttggctc     4440

tcagatcctc aaggagcacc ccgtcgagaa cactcagctg cagaacgaga agctgtacct     4500

gtactacctc caaaacggaa gggacatgta cgtggaccag gagctggaca tcaacaggtt     4560

gtccgactac gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga     4620

caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga     4680

ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca agctcatcac     4740

ccagcgtaag ttcgacaacc tgactaaggc tgagagagga ggattgtccg agctcgataa     4800

ggccggattc atcaagagac agctcgtcga aacccgccaa attaccaagc acgtggccca     4860

aattctggat tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt     4920

caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta     4980

caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca acgctgtcgt     5040

tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct gagttcgtct acggcgacta     5100

caaggtgtac gacgtgagga agatgatcgc taagtctgag caggagatcg gcaaggccac     5160

cgccaagtac ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc     5220

caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt     5280

gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa     5340

catcgtcaag aagaccgaag ttcagaccgg aggattctcc aaggagtcca tcctccccaa     5400

gagaaactcc gacaagctga tcgctagaaa gaaagactgg gaccctaaga agtacggagg     5460

cttcgattct cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa     5520

gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc     5580

cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg tgaagaagga     5640

cctcatcatc aagctgccca agtactccct cttcgagttg gagaacggaa ggaagaggat     5700

gctggcttct gccggagagt tgcagaaggg aaatgagctc gcccttccct ccaagtacgt     5760

gaacttcctg tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga     5820

gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat     5880

ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg tgctgtccgc     5940

ctacaacaag cacagggata agcccattcg cgagcaggct gaaaacatta tccacctgtt     6000

taccctcaca aacttgggag cccctgctgc cttcaagtac ttcgacacca ccattgacag     6060

gaagagatac acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac     6120

cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc     6180

caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga ttggccaact     6240

taattaatgt atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg     6300

gcatcaaagt tgtgtgttat gtgtaattac tagttatctg aataaaagag aaagagatca     6360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat     6420

gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat taatatcaat     6480

tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc aagcttatcg     6540

ataccgtcga gggggggccc ggtaccggcg cgccgttcta tagtgtcacc taaatcgtat     6600

gtgtatgata cataaggtta tgtattaatt gtagccgcgt tctaacgaca atatgtccat     6660

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     6720

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6780

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6840

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgaccaaaat     6900

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6960

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     7020

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     7080

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     7140

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     7200

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     7260

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     7320

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     7380

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     7440

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     7500

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     7560

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     7620

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     7680

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     7740

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcaggt tgatcagatc     7800

tcgatcccgc gaaattaata cgactcacta tagggagacc acaacggttt ccctctagaa     7860

ataattttgt ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga     7920

cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct     7980

cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga tatgtcctgc     8040

gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg cactttgcat     8100

cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag agcctgacct     8160

attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc     8220

ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc     8280

agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact acatggcgtg     8340

atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg atggacgaca     8400

ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc gaggactgcc     8460

ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg     8520

gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg     8580

tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag acgcgctact     8640

tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat atgctccgca     8700

ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat gcagcttggg     8760

cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa     8820

tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg     8880

gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca gcttggatcg     8940

atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat     9000

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag     9060

gaactatatc cggatgatcg ggcgcgccgg tac                                  9093


<210>  472
<211>  1357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1013A

<400>  472
ctagaagata aaccctcccc caaaacacaa attagaatga catttcaagt tccatgtatg       60

tcactttcat tctattattt ttacaacttt tagttactta acagatgtct tgttcagcat      120

aaattataat ttattctgtt tttttttagg gaacaactgt tgtagacaac ttgttgtata      180

gtgaggatat tcattacatg cttggtgcat taaggaccct tggactgcgt gtggaagatg      240

acaaaacaac caaacaagca attgttgaag gctgtggggg attgtttccc actagtaagg      300

aatctaaaga tgaaatcaat ttattccttg gaaatgctgg tattgcaatg agatctttga      360

cagcagctgt tgttgctgca ggtggaaatg caaggtctgt tttttttttt tttgttcagc      420

ataatctttg aattgttcct cgtataacta atcacaacag agtacgtgtt cttcttcctg      480

ttataatcta aaaatctcat ccagattagt catcctttct tcttaaaagg aacctttaat      540

tatcaatgta tttatttaat atttaaatta gcttgtcaaa gtctagcata tacatatttt      600

gattatattc tgagaaatgc acctgagggt gttcctcatg atctacttca acctctgtta      660

ttattagatt ttctatcatg attactggtt tgagtctcta agtagaccat cttgatgttc      720

aaaatatttc agctacgtac ttgatggggt gccccgaatg agagagaggc caattgggga      780

tttggttgct ggtcttaagc aacttggtgc agatgttgat tgctttcttg gcacaaactg      840

tccacctgtt cgtgtaaatg ggaagggagg acttcctggc ggaaaggtat ggtttggatt      900

tcatttagaa taaggtggag taactttcct ggatcaaaat tctaatttaa gaagcctccc      960

tgttttcctc tctttagaat aagactaagg gtaggtttag gagttgggtt ttggagagaa     1020

atggaaggga gagcaatttt tttcttcttc taataaatat tctttaattt gatacatttt     1080

ttaagtaaaa gaatataaag atagattagc ataacttaat gttttaatct tttatttatt     1140

tttataaata ttatatacct gtctatttaa aaatcaaata tttgtcctcc attccctttc     1200

ccttcaaaac ctcagttcca aatataccgt agttgaatta tattttggaa ggcctattgg     1260

ttggagactt ttccttttca gagattatcc ctcaccttta ttatagcctt tctattttta     1320

aacttcatat agacgccatt cttggggcgg ccgcgat                              1357


<210>  473
<211>  1357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1012A

<400>  473
ctagaagata aaccctcccc caaaacacaa attagaatga catttcaagt tccatgtatg       60

tcactttcat tctattattt ttacaacttt tagttactta acagatgtct tgttcagcat      120

aaattataat ttattctgtt tttttttagg gaacaactgt tgtagacaac ttgttgtata      180

gtgaggatat tcattacatg cttggtgcat taaggaccct tggactgcgt gtggaagatg      240

acaaaacaac caaacaagca attgttgaag gctgtggggg attgtttccc actagtaagg      300

aatctaaaga tgaaatcaat ttattccttg gaaatgctgg tattgcaatg agatctttga      360

cagcagctgt ggttgctgca ggtggaaatg caaggtctgt tttttttttt tttgttcagc      420

ataatctttg aattgttcct cgtataacta atcacaacag agtacgtgtt cttcttcctg      480

ttataatcta aaaatctcat ccagattagt catcctttct tcttaaaagg aacctttaat      540

tatcaatgta tttatttaat atttaaatta gcttgtcaaa gtctagcata tacatatttt      600

gattatattc tgagaaatgc acctgagggt gttcctcatg atctacttca acctctgtta      660

ttattagatt ttctatcatg attactggtt tgagtctcta agtagaccat cttgatgttc      720

aaaatatttc agctacgtac ttgatggggt gccccgaatg agagagaggc caattgggga      780

tttggttgct ggtcttaagc aacttggtgc agatgttgat tgctttcttg gcacaaactg      840

tccacctgtt cgtgtaaatg ggaagggagg acttcctggc ggaaaggtat ggtttggatt      900

tcatttagaa taaggtggag taactttcct ggatcaaaat tctaatttaa gaagcctccc      960

tgttttcctc tctttagaat aagactaagg gtaggtttag gagttgggtt ttggagagaa     1020

atggaaggga gagcaatttt tttcttcttc taataaatat tctttaattt gatacatttt     1080

ttaagtaaaa gaatataaag atagattagc ataacttaat gttttaatct tttatttatt     1140

tttataaata ttatatacct gtctatttaa aaatcaaata tttgtcctcc attccctttc     1200

ccttcaaaac ctcagttcca aatataccgt agttgaatta tattttggaa ggcctattgg     1260

ttggagactt ttccttttca gagattatcc ctcaccttta ttatagcctt tctattttta     1320

aacttcatat agacgccatt cttggggcgg ccgcgat                              1357


<210>  474
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>   primer, soy1-F1

<400>  474
ccactagtaa ggaatctaaa gatgaaatca                                        30


<210>  475
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, soy1-R2

<400>  475
cctgcagcaa ccacagctgc tgtc                                              24


<210>  476
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe, soy1-T1(FAM-MGB

<400>  476
ctgcaatgcg tcctt                                                        15


<210>  477
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, cas9-F

<400>  477
ccttcttcca ccgccttga                                                    19


<210>  478
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, Cas9-R

<400>  478
tgggtgtctc tcgtgctttt t                                                 21


<210>  479
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe, Cas9-T(FAM-MGB)

<400>  479
aatcattcct ggtggagga                                                    19


<210>  480
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, pINII-99F

<400>  480
tgatgcccac attatagtga ttagc                                             25


<210>  481
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, pINII-13R

<400>  481
catcttctgg attggccaac tt                                                22


<210>  482
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe, pINII-69T(FAM-MGB)

<400>  482
actatgtgtg catcctt                                                      17


<210>  483
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, SIP-130F

<400>  483
ttcaagttgg gctttttcag aag                                               23


<210>  484
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, SIP-198R

<400>  484
tctccttggt gctctcatca ca                                                22


<210>  485
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>   probe, SIP-170T(VIC-MGB)

<400>  485
ctgcagcaga accaa                                                        15


<210>  486
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  WOL569, Forward_primer

<400>  486
ggacccatta ggtgagagcg tggg                                              24


<210>  487
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  WOL876, Reverse_primer

<400>  487
cagctgctgt caaagatct                                                    19


<210>  488
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  WOL570, Reverse_primer

<400>  488
tctaataata acagaggttg aagtagatc                                         29


<210>  489
<211>  4104
<212>  DNA
<213>  Glycine max

<400>  489
atggacaaaa agtactcaat agggctcgac atagggacta actccgttgg atgggccgtc       60

atcaccgacg agtacaaggt gccctccaag aagttcaagg tgttgggaaa caccgacagg      120

cacagcataa agaagaattt gatcggtgcc ctcctcttcg actccggaga gaccgctgag      180

gctaccaggc tcaagaggac cgctagaagg cgctacacca gaaggaagaa cagaatctgc      240

tacctgcagg agatcttctc caacgagatg gccaaggtgg acgactcctt cttccaccgc      300

cttgaggaat cattcctggt ggaggaggat aaaaagcacg agagacaccc aatcttcggg      360

aacatcgtcg acgaggtggc ctaccatgaa aagtacccta ccatctacca cctgaggaag      420

aagctggtcg actctaccga caaggctgac ttgcgcttga tttacctggc tctcgctcac      480

atgataaagt tccgcggaca cttcctcatt gagggagacc tgaacccaga caactccgac      540

gtggacaagc tcttcatcca gctcgttcag acctacaacc agcttttcga ggagaaccca      600

atcaacgcca gtggagttga cgccaaggct atcctctctg ctcgtctgtc aaagtccagg      660

aggcttgaga acttgattgc ccagctgcct ggcgaaaaga agaacggact gttcggaaac      720

ttgatcgctc tctccctggg attgactccc aacttcaagt ccaacttcga cctcgccgag      780

gacgctaagt tgcagttgtc taaagacacc tacgacgatg acctcgacaa cttgctggcc      840

cagataggcg accaatacgc cgatctcttc ctcgccgcta agaacttgtc cgacgcaatc      900

ctgctgtccg acatcctgag agtcaacact gagattacca aagctcctct gtctgcttcc      960

atgattaagc gctacgacga gcaccaccaa gatctgaccc tgctcaaggc cctggtgaga     1020

cagcagctgc ccgagaagta caaggagatc tttttcgacc agtccaagaa cggctacgcc     1080

ggatacattg acggaggcgc ctcccaggaa gagttctaca agttcatcaa gcccatcctt     1140

gagaagatgg acggtaccga ggagctgttg gtgaagttga acagagagga cctgttgagg     1200

aagcagagaa ccttcgacaa cggaagcatc cctcaccaaa tccacctggg agagctccac     1260

gccatcttga ggaggcagga ggatttctat cccttcctga aggacaaccg cgagaagatt     1320

gagaagatct tgaccttcag aattccttac tacgtcgggc cactcgccag aggaaactct     1380

aggttcgcct ggatgacccg caaatctgaa gagaccatta ctccctggaa cttcgaggaa     1440

gtcgtggaca agggcgcttc cgctcagtct ttcatcgaga ggatgaccaa cttcgataaa     1500

aatctgccca acgagaaggt gctgcccaag cactccctgt tgtacgagta tttcacagtg     1560

tacaacgagc tcaccaaggt gaagtacgtc acagagggaa tgaggaagcc tgccttcttg     1620

tccggagagc agaagaaggc catcgtcgac ctgctcttca agaccaacag gaaggtgact     1680

gtcaagcagc tgaaggagga ctacttcaag aagatcgagt gcttcgactc cgtcgagatc     1740

tctggtgtcg aggacaggtt caacgcctcc cttgggactt accacgatct gctcaagatt     1800

attaaagaca aggacttcct ggacaacgag gagaacgagg acatccttga ggacatcgtg     1860

ctcaccctga ccttgttcga agacagggaa atgatcgaag agaggctcaa gacctacgcc     1920

cacctcttcg acgacaaggt gatgaaacag ctgaagagac gcagatatac cggctgggga     1980

aggctctccc gcaaattgat caacgggatc agggacaagc agtcagggaa gactatactc     2040

gacttcctga agtccgacgg attcgccaac aggaacttca tgcagctcat tcacgacgac     2100

tccttgacct tcaaggagga catccagaag gctcaggtgt ctggacaggg tgactccttg     2160

catgagcaca ttgctaactt ggccggctct cccgctatta agaagggcat tttgcagacc     2220

gtgaaggtcg ttgacgagct cgtgaaggtg atgggacgcc acaagccaga gaacatcgtt     2280

attgagatgg ctcgcgagaa ccaaactacc cagaaagggc agaagaattc ccgcgagagg     2340

atgaagcgca ttgaggaggg cataaaagag cttggctctc agatcctcaa ggagcacccc     2400

gtcgagaaca ctcagctgca gaacgagaag ctgtacctgt actacctcca aaacggaagg     2460

gacatgtacg tggaccagga gctggacatc aacaggttgt ccgactacga cgtcgaccac     2520

atcgtgcctc agtccttcct gaaggatgac tccatcgaca ataaagtgct gacacgctcc     2580

gataaaaata gaggcaagtc cgacaacgtc ccctccgagg aggtcgtgaa gaagatgaaa     2640

aactactgga gacagctctt gaacgccaag ctcatcaccc agcgtaagtt cgacaacctg     2700

actaaggctg agagaggagg attgtccgag ctcgataagg ccggattcat caagagacag     2760

ctcgtcgaaa cccgccaaat taccaagcac gtggcccaaa ttctggattc ccgcatgaac     2820

accaagtacg atgaaaatga caagctgatc cgcgaggtca aggtgatcac cttgaagtcc     2880

aagctggtct ccgacttccg caaggacttc cagttctaca aggtgaggga gatcaacaac     2940

taccaccacg cacacgacgc ctacctcaac gctgtcgttg gaaccgccct catcaaaaaa     3000

tatcctaagc tggagtctga gttcgtctac ggcgactaca aggtgtacga cgtgaggaag     3060

atgatcgcta agtctgagca ggagatcggc aaggccaccg ccaagtactt cttctactcc     3120

aacatcatga acttcttcaa gaccgagatc actctcgcca acggtgagat caggaagcgc     3180

ccactgatcg agaccaacgg tgagactgga gagatcgtgt gggacaaagg gagggatttc     3240

gctactgtga ggaaggtgct ctccatgcct caggtgaaca tcgtcaagaa gaccgaagtt     3300

cagaccggag gattctccaa ggagtccatc ctccccaaga gaaactccga caagctgatc     3360

gctagaaaga aagactggga ccctaagaag tacggaggct tcgattctcc taccgtggcc     3420

tactctgtgc tggtcgtggc caaggtggag aagggcaagt ccaagaagct gaaatccgtc     3480

aaggagctcc tcgggattac catcatggag aggagttcct tcgagaagaa ccctatcgac     3540

ttcctggagg ccaagggata taaagaggtg aagaaggacc tcatcatcaa gctgcccaag     3600

tactccctct tcgagttgga gaacggaagg aagaggatgc tggcttctgc cggagagttg     3660

cagaagggaa atgagctcgc ccttccctcc aagtacgtga acttcctgta cctcgcctct     3720

cactatgaaa agttgaaggg ctctcctgag gacaacgagc agaagcagct cttcgtggag     3780

cagcacaagc actacctgga cgaaattatc gagcagatct ctgagttctc caagcgcgtg     3840

atattggccg acgccaacct cgacaaggtg ctgtccgcct acaacaagca cagggataag     3900

cccattcgcg agcaggctga aaacattatc cacctgttta ccctcacaaa cttgggagcc     3960

cctgctgcct tcaagtactt cgacaccacc attgacagga agagatacac ctccaccaag     4020

gaggtgctcg acgcaacact catccaccaa tccatcaccg gcctctatga aacaaggatt     4080

gacttgtccc agctgggagg cgac                                            4104


<210>  490
<211>  23
<212>  DNA
<213>  Glycine max

<400>  490
gtttgtttgt tgttgggtgt ggg                                               23


<210>  491
<211>  22
<212>  DNA
<213>  Glycine max

<400>  491
tgttgttggg tgtgggaata gg                                                22


<210>  492
<211>  9174
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1199

<400>  492
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg tttgtttgtt gttgggtgtg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggcacc gaagaagaag cgcaaggtga tggacaaaaa     2100

gtactcaata gggctcgaca tagggactaa ctccgttgga tgggccgtca tcaccgacga     2160

gtacaaggtg ccctccaaga agttcaaggt gttgggaaac accgacaggc acagcataaa     2220

gaagaatttg atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct     2280

caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct acctgcagga     2340

gatcttctcc aacgagatgg ccaaggtgga cgactccttc ttccaccgcc ttgaggaatc     2400

attcctggtg gaggaggata aaaagcacga gagacaccca atcttcggga acatcgtcga     2460

cgaggtggcc taccatgaaa agtaccctac catctaccac ctgaggaaga agctggtcga     2520

ctctaccgac aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt     2580

ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg tggacaagct     2640

cttcatccag ctcgttcaga cctacaacca gcttttcgag gagaacccaa tcaacgccag     2700

tggagttgac gccaaggcta tcctctctgc tcgtctgtca aagtccagga ggcttgagaa     2760

cttgattgcc cagctgcctg gcgaaaagaa gaacggactg ttcggaaact tgatcgctct     2820

ctccctggga ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt     2880

gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc agataggcga     2940

ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc gacgcaatcc tgctgtccga     3000

catcctgaga gtcaacactg agattaccaa agctcctctg tctgcttcca tgattaagcg     3060

ctacgacgag caccaccaag atctgaccct gctcaaggcc ctggtgagac agcagctgcc     3120

cgagaagtac aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga     3180

cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg agaagatgga     3240

cggtaccgag gagctgttgg tgaagttgaa cagagaggac ctgttgagga agcagagaac     3300

cttcgacaac ggaagcatcc ctcaccaaat ccacctggga gagctccacg ccatcttgag     3360

gaggcaggag gatttctatc ccttcctgaa ggacaaccgc gagaagattg agaagatctt     3420

gaccttcaga attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg     3480

gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag tcgtggacaa     3540

gggcgcttcc gctcagtctt tcatcgagag gatgaccaac ttcgataaaa atctgcccaa     3600

cgagaaggtg ctgcccaagc actccctgtt gtacgagtat ttcacagtgt acaacgagct     3660

caccaaggtg aagtacgtca cagagggaat gaggaagcct gccttcttgt ccggagagca     3720

gaagaaggcc atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct     3780

gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct ctggtgtcga     3840

ggacaggttc aacgcctccc ttgggactta ccacgatctg ctcaagatta ttaaagacaa     3900

ggacttcctg gacaacgagg agaacgagga catccttgag gacatcgtgc tcaccctgac     3960

cttgttcgaa gacagggaaa tgatcgaaga gaggctcaag acctacgccc acctcttcga     4020

cgacaaggtg atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg     4080

caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg acttcctgaa     4140

gtccgacgga ttcgccaaca ggaacttcat gcagctcatt cacgacgact ccttgacctt     4200

caaggaggac atccagaagg ctcaggtgtc tggacagggt gactccttgc atgagcacat     4260

tgctaacttg gccggctctc ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt     4320

tgacgagctc gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc     4380

tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga tgaagcgcat     4440

tgaggagggc ataaaagagc ttggctctca gatcctcaag gagcaccccg tcgagaacac     4500

tcagctgcag aacgagaagc tgtacctgta ctacctccaa aacggaaggg acatgtacgt     4560

ggaccaggag ctggacatca acaggttgtc cgactacgac gtcgaccaca tcgtgcctca     4620

gtccttcctg aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag     4680

aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa actactggag     4740

acagctcttg aacgccaagc tcatcaccca gcgtaagttc gacaacctga ctaaggctga     4800

gagaggagga ttgtccgagc tcgataaggc cggattcatc aagagacagc tcgtcgaaac     4860

ccgccaaatt accaagcacg tggcccaaat tctggattcc cgcatgaaca ccaagtacga     4920

tgaaaatgac aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc     4980

cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact accaccacgc     5040

acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc atcaaaaaat atcctaagct     5100

ggagtctgag ttcgtctacg gcgactacaa ggtgtacgac gtgaggaaga tgatcgctaa     5160

gtctgagcag gagatcggca aggccaccgc caagtacttc ttctactcca acatcatgaa     5220

cttcttcaag accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga     5280

gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg ctactgtgag     5340

gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag accgaagttc agaccggagg     5400

attctccaag gagtccatcc tccccaagag aaactccgac aagctgatcg ctagaaagaa     5460

agactgggac cctaagaagt acggaggctt cgattctcct accgtggcct actctgtgct     5520

ggtcgtggcc aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct     5580

cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact tcctggaggc     5640

caagggatat aaagaggtga agaaggacct catcatcaag ctgcccaagt actccctctt     5700

cgagttggag aacggaagga agaggatgct ggcttctgcc ggagagttgc agaagggaaa     5760

tgagctcgcc cttccctcca agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa     5820

gttgaagggc tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca     5880

ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga tattggccga     5940

cgccaacctc gacaaggtgc tgtccgccta caacaagcac agggataagc ccattcgcga     6000

gcaggctgaa aacattatcc acctgtttac cctcacaaac ttgggagccc ctgctgcctt     6060

caagtacttc gacaccacca ttgacaggaa gagatacacc tccaccaagg aggtgctcga     6120

cgcaacactc atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca     6180

gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga gaccacggga     6240

ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg taggttaacc tagacttgtc     6300

catcttctgg attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac     6360

atgctaatca ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct     6420

gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta     6480

taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa     6540

tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg     6600

aattcgatat caagcttatc gataccgtcg agggggggcc cggtaccggc gcgccgttct     6660

atagtgtcac ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg     6720

ttctaacgac aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata     6780

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     6840

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     6900

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     6960

ggttaatgtc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7020

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7080

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7140

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     7200

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7260

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7320

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7380

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     7440

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     7500

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     7560

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     7620

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7680

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7740

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7800

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7860

ttaatgcagg ttgatcagat ctcgatcccg cgaaattaat acgactcact atagggagac     7920

cacaacggtt tccctctaga aataattttg tttaacttta agaaggagat atacccatgg     7980

aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg     8040

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag     8100

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt     8160

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg     8220

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag     8280

acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct atggatgcga     8340

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg     8400

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact     8460

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga     8520

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca     8580

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt     8640

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta     8700

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc     8760

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca     8820

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg     8880

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg     8940

tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat     9000

agtgaggtac agcttggatc gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg     9060

ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga     9120

ggggtttttt gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac           9174


<210>  493
<211>  9174
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1200

<400>  493
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg tgttgttggg tgtgggaatg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggcacc gaagaagaag cgcaaggtga tggacaaaaa     2100

gtactcaata gggctcgaca tagggactaa ctccgttgga tgggccgtca tcaccgacga     2160

gtacaaggtg ccctccaaga agttcaaggt gttgggaaac accgacaggc acagcataaa     2220

gaagaatttg atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct     2280

caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct acctgcagga     2340

gatcttctcc aacgagatgg ccaaggtgga cgactccttc ttccaccgcc ttgaggaatc     2400

attcctggtg gaggaggata aaaagcacga gagacaccca atcttcggga acatcgtcga     2460

cgaggtggcc taccatgaaa agtaccctac catctaccac ctgaggaaga agctggtcga     2520

ctctaccgac aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt     2580

ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg tggacaagct     2640

cttcatccag ctcgttcaga cctacaacca gcttttcgag gagaacccaa tcaacgccag     2700

tggagttgac gccaaggcta tcctctctgc tcgtctgtca aagtccagga ggcttgagaa     2760

cttgattgcc cagctgcctg gcgaaaagaa gaacggactg ttcggaaact tgatcgctct     2820

ctccctggga ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt     2880

gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc agataggcga     2940

ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc gacgcaatcc tgctgtccga     3000

catcctgaga gtcaacactg agattaccaa agctcctctg tctgcttcca tgattaagcg     3060

ctacgacgag caccaccaag atctgaccct gctcaaggcc ctggtgagac agcagctgcc     3120

cgagaagtac aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga     3180

cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg agaagatgga     3240

cggtaccgag gagctgttgg tgaagttgaa cagagaggac ctgttgagga agcagagaac     3300

cttcgacaac ggaagcatcc ctcaccaaat ccacctggga gagctccacg ccatcttgag     3360

gaggcaggag gatttctatc ccttcctgaa ggacaaccgc gagaagattg agaagatctt     3420

gaccttcaga attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg     3480

gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag tcgtggacaa     3540

gggcgcttcc gctcagtctt tcatcgagag gatgaccaac ttcgataaaa atctgcccaa     3600

cgagaaggtg ctgcccaagc actccctgtt gtacgagtat ttcacagtgt acaacgagct     3660

caccaaggtg aagtacgtca cagagggaat gaggaagcct gccttcttgt ccggagagca     3720

gaagaaggcc atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct     3780

gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct ctggtgtcga     3840

ggacaggttc aacgcctccc ttgggactta ccacgatctg ctcaagatta ttaaagacaa     3900

ggacttcctg gacaacgagg agaacgagga catccttgag gacatcgtgc tcaccctgac     3960

cttgttcgaa gacagggaaa tgatcgaaga gaggctcaag acctacgccc acctcttcga     4020

cgacaaggtg atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg     4080

caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg acttcctgaa     4140

gtccgacgga ttcgccaaca ggaacttcat gcagctcatt cacgacgact ccttgacctt     4200

caaggaggac atccagaagg ctcaggtgtc tggacagggt gactccttgc atgagcacat     4260

tgctaacttg gccggctctc ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt     4320

tgacgagctc gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc     4380

tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga tgaagcgcat     4440

tgaggagggc ataaaagagc ttggctctca gatcctcaag gagcaccccg tcgagaacac     4500

tcagctgcag aacgagaagc tgtacctgta ctacctccaa aacggaaggg acatgtacgt     4560

ggaccaggag ctggacatca acaggttgtc cgactacgac gtcgaccaca tcgtgcctca     4620

gtccttcctg aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag     4680

aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa actactggag     4740

acagctcttg aacgccaagc tcatcaccca gcgtaagttc gacaacctga ctaaggctga     4800

gagaggagga ttgtccgagc tcgataaggc cggattcatc aagagacagc tcgtcgaaac     4860

ccgccaaatt accaagcacg tggcccaaat tctggattcc cgcatgaaca ccaagtacga     4920

tgaaaatgac aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc     4980

cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact accaccacgc     5040

acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc atcaaaaaat atcctaagct     5100

ggagtctgag ttcgtctacg gcgactacaa ggtgtacgac gtgaggaaga tgatcgctaa     5160

gtctgagcag gagatcggca aggccaccgc caagtacttc ttctactcca acatcatgaa     5220

cttcttcaag accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga     5280

gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg ctactgtgag     5340

gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag accgaagttc agaccggagg     5400

attctccaag gagtccatcc tccccaagag aaactccgac aagctgatcg ctagaaagaa     5460

agactgggac cctaagaagt acggaggctt cgattctcct accgtggcct actctgtgct     5520

ggtcgtggcc aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct     5580

cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact tcctggaggc     5640

caagggatat aaagaggtga agaaggacct catcatcaag ctgcccaagt actccctctt     5700

cgagttggag aacggaagga agaggatgct ggcttctgcc ggagagttgc agaagggaaa     5760

tgagctcgcc cttccctcca agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa     5820

gttgaagggc tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca     5880

ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga tattggccga     5940

cgccaacctc gacaaggtgc tgtccgccta caacaagcac agggataagc ccattcgcga     6000

gcaggctgaa aacattatcc acctgtttac cctcacaaac ttgggagccc ctgctgcctt     6060

caagtacttc gacaccacca ttgacaggaa gagatacacc tccaccaagg aggtgctcga     6120

cgcaacactc atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca     6180

gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga gaccacggga     6240

ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg taggttaacc tagacttgtc     6300

catcttctgg attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac     6360

atgctaatca ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct     6420

gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta     6480

taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa     6540

tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg     6600

aattcgatat caagcttatc gataccgtcg agggggggcc cggtaccggc gcgccgttct     6660

atagtgtcac ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg     6720

ttctaacgac aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata     6780

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     6840

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     6900

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     6960

ggttaatgtc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7020

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7080

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7140

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     7200

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7260

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7320

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7380

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     7440

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     7500

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     7560

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     7620

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7680

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7740

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7800

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7860

ttaatgcagg ttgatcagat ctcgatcccg cgaaattaat acgactcact atagggagac     7920

cacaacggtt tccctctaga aataattttg tttaacttta agaaggagat atacccatgg     7980

aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg     8040

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag     8100

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt     8160

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg     8220

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag     8280

acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct atggatgcga     8340

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg     8400

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact     8460

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga     8520

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca     8580

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt     8640

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta     8700

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc     8760

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca     8820

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg     8880

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg     8940

tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat     9000

agtgaggtac agcttggatc gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg     9060

ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga     9120

ggggtttttt gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac           9174


<210>  494
<211>  3175
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1190A

<400>  494
cgaattctac aggtcactaa taccatctaa gtagttggtt catagtgact gcatatgtaa       60

aaattatcct tattttaagg aaattaaaaa ttatcatata tatataagtt ttaaattaat      120

tatcttatat atgtaccaaa aagttttaaa gcaattatta taaaaattaa taaatttatc      180

atataaaata atttataatt aaattttaaa ttatcaattc attaaattaa attatttaaa      240

atttttgaat gataatataa taattttatc ctctactaag tcccaacgtt tcctatttta      300

ttccactttt agcaataaat tttgtcataa acacttataa caaaaaaagt aagtaaaaaa      360

taaaaaaaag tttttcaata aagtataaac taatttgtat aaacttttag aaaaaataaa      420

gttatacatt gataatataa attttttaca taattatccg atcaactcat tatatatgat      480

aaatttattg attttttaaa ataattatct taaaataatt taaacaatga tttgcaatta      540

gatgataata taaaattatt ttacacacta catgtattaa actcaaactt ttatatatta      600

gtttttctaa aaactaattt ttaactcaaa aaaaatgtta cttataattt tcttatcttc      660

tttttttata agtatttttt aagaaattta ttgaaacatg accatgcttg ggtcaataat      720

actactctct tagacaccaa acaacccttc ccaaactata atctaatcca aaagccatca      780

ttcattttcc ttggtaggta aagttccaag accttcacca actttttcac tcaattgttt      840

tggtgtaagc aattcgacat gtgttagtgt tagttggcaa ccaaaaatcc ctttatgtga      900

ctcaatccaa caaccactca caccaccaac ccccataacc atttctcaca atacccttca      960

tttacacatt atcatcacca aaaataaata aaaaaaacct ctcatttcag agagagagag     1020

agagacttca cagaccaaag tgcagagaac aacaaagttc acaactttaa ggaaaattga     1080

aatggcccaa gtgagcagag tgcacaatct tgctcaaagc actcaaattt ttggccattc     1140

ttccaactcc aacaaactca aatcggtgaa ttcggtttca ttgaggccac gcctttgggg     1200

ggcctcaaaa tctcgcatcc cgatgcataa aaatggaagc tttatgggaa attttaatgt     1260

ggggaaggga aattccggcg tgtttaaggt ttctgcatcg gtcgccgccg cagagaagcc     1320

gtcaacgtcg ccggagatcg tgttggaacc catcaaagac ttctcgggta ccatcacatt     1380

gccagggtcc aagtctctgt ccaatcgaat tttgcttctt gctgctctct ctgaggttcg     1440

tagatttctt ccgttttttt ttcttcttct ttattgtttg ttctacatca gcatgatgtt     1500

gatttgattg tgttttctat cgtttcatcg attataaatt ttcataatca gaagattcag     1560

cttttattaa tgcaagaacg tccttaattg atgattttat aaccgtaaat taggtctaat     1620

tagagttttt ttcataaaga ttttcagatc cgtttacaac aagccttaat tgttgattct     1680

gtagtcgtag attaaggttt ttttcatgaa ctacttcaga tccgttaaac aacagcctta     1740

tttgttgata cttcagtcgt ttttcaagaa attgttcaga tccgttgata aaagccttat     1800

tcgttgattc tgtatggtat ttcaagagat attgctcagg tcctttagca actaccttat     1860

ttgttgattc tgtggccata gattaggatt ttttttcacg aaattgcttc ttgaaattac     1920

gtgatggatt ttgattctga tttatcttgt gattgttgac tctacaggga acaactgttg     1980

tagacaactt gttgtatagt gaggatattc attacatgct tggtgcatta aggacccttg     2040

gactgcgtgt ggaagatgac aaaacaacca aacaagcaat tgttgaaggc tgtgggggat     2100

tgtttcccac tagtaaggaa tctaaagatg aaatcaattt attccttgga aatgctggta     2160

ttgcaatgag atctttgaca gcagctgttg ttgctgcagg tggaaatgca aggtctgttt     2220

tttttttttt tgttcagcat aatctttgaa ttgttcctcg tataactaat cacaacagag     2280

tacgtgttct tcttcctgtt ataatctaaa aatctcatcc agattagtca tcctttcttc     2340

ttaaaaggaa cctttaatta tcaatgtatt tatttaatat ttaaattagc ttgtcaaagt     2400

ctagcatata catattttga ttatattctg agaaatgcac ctgagggtgt tcctcatgat     2460

ctacttcaac ctctgttatt attagatttt ctatcatgat tactggtttg agtctctaag     2520

tagaccatct tgatgttcaa aatatttcag ctacgtactt gatggggtgc cccgaatgag     2580

agagaggcca attggggatt tggttgctgg tcttaagcaa cttggtgcag atgttgattg     2640

ctttcttggc acaaactgtc cacctgttcg tgtaaatggg aagggaggac ttcctggcgg     2700

aaaggtatgg tttggatttc atttagaata aggtggagta actttcctgg atcaaaattc     2760

taatttaaga agcctccctg ttttcctctc tttagaataa gactaagggt aggtttagga     2820

gttgggtttt ggagagaaat ggaagggaga gcaatttttt tcttcttcta ataaatattc     2880

tttaatttga tacatttttt aagtaaaaga atataaagat agattagcat aacttaatgt     2940

tttaatcttt tatttatttt tataaatatt atatacctgt ctatttaaaa atcaaatatt     3000

tgtcctccat tccctttccc ttcaaaacct cagttccaaa tataccgtag ttgaattata     3060

ttttggaagg cctattggtt ggagactttt ccttttcaga gattatccct cacctttatt     3120

atagcctttc tatttttaaa cttcatatag acgccattct tggggcggcc gcgat          3175


<210>  495
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>   primer, soy1-F3

<400>  495
gtttgtttgt tgttgggtgt ggg                                               23


<210>  496
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, soy1-R3

<400>  496
gacatgatgc ttcattttca cagaa                                             25


<210>  497
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  robe, soy1-T2(FAM-MGB)

<400>  497
tgtgtagagt ggattttg                                                     18


<210>  498
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, soy1-F2

<400>  498
tgttgttggg tgtgggaata gg                                                22


<210>  499
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>   WOL1001, Forward_primer

<400>  499
aggtttaatt ttatataatg ttagcataca g                                      31


<210>  500
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  500 WOL1002, Reverse_primer

<400>  500
atcaacatca tgctgatgta gaacaaac                                          28


<210>  501
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  501 WOL1003, Forward_primer

<400>  501
attctgattt atcttgtgat tgttgactc                                         29


<210>  502
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  WOL1004, Reverse_primer

<400>  502
atttactttg gagagaataa ggagggg                                           27


<210>  503
<211>  23
<212>  DNA
<213>  Glycine mac

<400>  503
gaaacgttgg gacttagtag agg                                               23


<210>  504
<211>  23
<212>  DNA
<213>  Glycine max

<400>  504
ggaataaaat aggaaacgtt ggg                                               23


<210>  505
<211>  9174
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1201

<400>  505
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg aaacgttggg acttagtagg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggcacc gaagaagaag cgcaaggtga tggacaaaaa     2100

gtactcaata gggctcgaca tagggactaa ctccgttgga tgggccgtca tcaccgacga     2160

gtacaaggtg ccctccaaga agttcaaggt gttgggaaac accgacaggc acagcataaa     2220

gaagaatttg atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct     2280

caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct acctgcagga     2340

gatcttctcc aacgagatgg ccaaggtgga cgactccttc ttccaccgcc ttgaggaatc     2400

attcctggtg gaggaggata aaaagcacga gagacaccca atcttcggga acatcgtcga     2460

cgaggtggcc taccatgaaa agtaccctac catctaccac ctgaggaaga agctggtcga     2520

ctctaccgac aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt     2580

ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg tggacaagct     2640

cttcatccag ctcgttcaga cctacaacca gcttttcgag gagaacccaa tcaacgccag     2700

tggagttgac gccaaggcta tcctctctgc tcgtctgtca aagtccagga ggcttgagaa     2760

cttgattgcc cagctgcctg gcgaaaagaa gaacggactg ttcggaaact tgatcgctct     2820

ctccctggga ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt     2880

gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc agataggcga     2940

ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc gacgcaatcc tgctgtccga     3000

catcctgaga gtcaacactg agattaccaa agctcctctg tctgcttcca tgattaagcg     3060

ctacgacgag caccaccaag atctgaccct gctcaaggcc ctggtgagac agcagctgcc     3120

cgagaagtac aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga     3180

cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg agaagatgga     3240

cggtaccgag gagctgttgg tgaagttgaa cagagaggac ctgttgagga agcagagaac     3300

cttcgacaac ggaagcatcc ctcaccaaat ccacctggga gagctccacg ccatcttgag     3360

gaggcaggag gatttctatc ccttcctgaa ggacaaccgc gagaagattg agaagatctt     3420

gaccttcaga attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg     3480

gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag tcgtggacaa     3540

gggcgcttcc gctcagtctt tcatcgagag gatgaccaac ttcgataaaa atctgcccaa     3600

cgagaaggtg ctgcccaagc actccctgtt gtacgagtat ttcacagtgt acaacgagct     3660

caccaaggtg aagtacgtca cagagggaat gaggaagcct gccttcttgt ccggagagca     3720

gaagaaggcc atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct     3780

gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct ctggtgtcga     3840

ggacaggttc aacgcctccc ttgggactta ccacgatctg ctcaagatta ttaaagacaa     3900

ggacttcctg gacaacgagg agaacgagga catccttgag gacatcgtgc tcaccctgac     3960

cttgttcgaa gacagggaaa tgatcgaaga gaggctcaag acctacgccc acctcttcga     4020

cgacaaggtg atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg     4080

caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg acttcctgaa     4140

gtccgacgga ttcgccaaca ggaacttcat gcagctcatt cacgacgact ccttgacctt     4200

caaggaggac atccagaagg ctcaggtgtc tggacagggt gactccttgc atgagcacat     4260

tgctaacttg gccggctctc ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt     4320

tgacgagctc gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc     4380

tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga tgaagcgcat     4440

tgaggagggc ataaaagagc ttggctctca gatcctcaag gagcaccccg tcgagaacac     4500

tcagctgcag aacgagaagc tgtacctgta ctacctccaa aacggaaggg acatgtacgt     4560

ggaccaggag ctggacatca acaggttgtc cgactacgac gtcgaccaca tcgtgcctca     4620

gtccttcctg aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag     4680

aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa actactggag     4740

acagctcttg aacgccaagc tcatcaccca gcgtaagttc gacaacctga ctaaggctga     4800

gagaggagga ttgtccgagc tcgataaggc cggattcatc aagagacagc tcgtcgaaac     4860

ccgccaaatt accaagcacg tggcccaaat tctggattcc cgcatgaaca ccaagtacga     4920

tgaaaatgac aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc     4980

cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact accaccacgc     5040

acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc atcaaaaaat atcctaagct     5100

ggagtctgag ttcgtctacg gcgactacaa ggtgtacgac gtgaggaaga tgatcgctaa     5160

gtctgagcag gagatcggca aggccaccgc caagtacttc ttctactcca acatcatgaa     5220

cttcttcaag accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga     5280

gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg ctactgtgag     5340

gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag accgaagttc agaccggagg     5400

attctccaag gagtccatcc tccccaagag aaactccgac aagctgatcg ctagaaagaa     5460

agactgggac cctaagaagt acggaggctt cgattctcct accgtggcct actctgtgct     5520

ggtcgtggcc aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct     5580

cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact tcctggaggc     5640

caagggatat aaagaggtga agaaggacct catcatcaag ctgcccaagt actccctctt     5700

cgagttggag aacggaagga agaggatgct ggcttctgcc ggagagttgc agaagggaaa     5760

tgagctcgcc cttccctcca agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa     5820

gttgaagggc tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca     5880

ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga tattggccga     5940

cgccaacctc gacaaggtgc tgtccgccta caacaagcac agggataagc ccattcgcga     6000

gcaggctgaa aacattatcc acctgtttac cctcacaaac ttgggagccc ctgctgcctt     6060

caagtacttc gacaccacca ttgacaggaa gagatacacc tccaccaagg aggtgctcga     6120

cgcaacactc atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca     6180

gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga gaccacggga     6240

ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg taggttaacc tagacttgtc     6300

catcttctgg attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac     6360

atgctaatca ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct     6420

gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta     6480

taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa     6540

tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg     6600

aattcgatat caagcttatc gataccgtcg agggggggcc cggtaccggc gcgccgttct     6660

atagtgtcac ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg     6720

ttctaacgac aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata     6780

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     6840

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     6900

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     6960

ggttaatgtc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7020

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7080

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7140

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     7200

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7260

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7320

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7380

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     7440

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     7500

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     7560

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     7620

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7680

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7740

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7800

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7860

ttaatgcagg ttgatcagat ctcgatcccg cgaaattaat acgactcact atagggagac     7920

cacaacggtt tccctctaga aataattttg tttaacttta agaaggagat atacccatgg     7980

aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg     8040

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag     8100

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt     8160

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg     8220

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag     8280

acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct atggatgcga     8340

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg     8400

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact     8460

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga     8520

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca     8580

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt     8640

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta     8700

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc     8760

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca     8820

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg     8880

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg     8940

tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat     9000

agtgaggtac agcttggatc gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg     9060

ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga     9120

ggggtttttt gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac           9174


<210>  506
<211>  9174
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1202

<400>  506
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg gaataaaata ggaaacgttg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggcacc gaagaagaag cgcaaggtga tggacaaaaa     2100

gtactcaata gggctcgaca tagggactaa ctccgttgga tgggccgtca tcaccgacga     2160

gtacaaggtg ccctccaaga agttcaaggt gttgggaaac accgacaggc acagcataaa     2220

gaagaatttg atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct     2280

caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct acctgcagga     2340

gatcttctcc aacgagatgg ccaaggtgga cgactccttc ttccaccgcc ttgaggaatc     2400

attcctggtg gaggaggata aaaagcacga gagacaccca atcttcggga acatcgtcga     2460

cgaggtggcc taccatgaaa agtaccctac catctaccac ctgaggaaga agctggtcga     2520

ctctaccgac aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt     2580

ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg tggacaagct     2640

cttcatccag ctcgttcaga cctacaacca gcttttcgag gagaacccaa tcaacgccag     2700

tggagttgac gccaaggcta tcctctctgc tcgtctgtca aagtccagga ggcttgagaa     2760

cttgattgcc cagctgcctg gcgaaaagaa gaacggactg ttcggaaact tgatcgctct     2820

ctccctggga ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt     2880

gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc agataggcga     2940

ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc gacgcaatcc tgctgtccga     3000

catcctgaga gtcaacactg agattaccaa agctcctctg tctgcttcca tgattaagcg     3060

ctacgacgag caccaccaag atctgaccct gctcaaggcc ctggtgagac agcagctgcc     3120

cgagaagtac aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga     3180

cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg agaagatgga     3240

cggtaccgag gagctgttgg tgaagttgaa cagagaggac ctgttgagga agcagagaac     3300

cttcgacaac ggaagcatcc ctcaccaaat ccacctggga gagctccacg ccatcttgag     3360

gaggcaggag gatttctatc ccttcctgaa ggacaaccgc gagaagattg agaagatctt     3420

gaccttcaga attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg     3480

gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag tcgtggacaa     3540

gggcgcttcc gctcagtctt tcatcgagag gatgaccaac ttcgataaaa atctgcccaa     3600

cgagaaggtg ctgcccaagc actccctgtt gtacgagtat ttcacagtgt acaacgagct     3660

caccaaggtg aagtacgtca cagagggaat gaggaagcct gccttcttgt ccggagagca     3720

gaagaaggcc atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct     3780

gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct ctggtgtcga     3840

ggacaggttc aacgcctccc ttgggactta ccacgatctg ctcaagatta ttaaagacaa     3900

ggacttcctg gacaacgagg agaacgagga catccttgag gacatcgtgc tcaccctgac     3960

cttgttcgaa gacagggaaa tgatcgaaga gaggctcaag acctacgccc acctcttcga     4020

cgacaaggtg atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg     4080

caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg acttcctgaa     4140

gtccgacgga ttcgccaaca ggaacttcat gcagctcatt cacgacgact ccttgacctt     4200

caaggaggac atccagaagg ctcaggtgtc tggacagggt gactccttgc atgagcacat     4260

tgctaacttg gccggctctc ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt     4320

tgacgagctc gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc     4380

tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga tgaagcgcat     4440

tgaggagggc ataaaagagc ttggctctca gatcctcaag gagcaccccg tcgagaacac     4500

tcagctgcag aacgagaagc tgtacctgta ctacctccaa aacggaaggg acatgtacgt     4560

ggaccaggag ctggacatca acaggttgtc cgactacgac gtcgaccaca tcgtgcctca     4620

gtccttcctg aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag     4680

aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa actactggag     4740

acagctcttg aacgccaagc tcatcaccca gcgtaagttc gacaacctga ctaaggctga     4800

gagaggagga ttgtccgagc tcgataaggc cggattcatc aagagacagc tcgtcgaaac     4860

ccgccaaatt accaagcacg tggcccaaat tctggattcc cgcatgaaca ccaagtacga     4920

tgaaaatgac aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc     4980

cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact accaccacgc     5040

acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc atcaaaaaat atcctaagct     5100

ggagtctgag ttcgtctacg gcgactacaa ggtgtacgac gtgaggaaga tgatcgctaa     5160

gtctgagcag gagatcggca aggccaccgc caagtacttc ttctactcca acatcatgaa     5220

cttcttcaag accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga     5280

gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg ctactgtgag     5340

gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag accgaagttc agaccggagg     5400

attctccaag gagtccatcc tccccaagag aaactccgac aagctgatcg ctagaaagaa     5460

agactgggac cctaagaagt acggaggctt cgattctcct accgtggcct actctgtgct     5520

ggtcgtggcc aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct     5580

cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact tcctggaggc     5640

caagggatat aaagaggtga agaaggacct catcatcaag ctgcccaagt actccctctt     5700

cgagttggag aacggaagga agaggatgct ggcttctgcc ggagagttgc agaagggaaa     5760

tgagctcgcc cttccctcca agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa     5820

gttgaagggc tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca     5880

ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga tattggccga     5940

cgccaacctc gacaaggtgc tgtccgccta caacaagcac agggataagc ccattcgcga     6000

gcaggctgaa aacattatcc acctgtttac cctcacaaac ttgggagccc ctgctgcctt     6060

caagtacttc gacaccacca ttgacaggaa gagatacacc tccaccaagg aggtgctcga     6120

cgcaacactc atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca     6180

gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga gaccacggga     6240

ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg taggttaacc tagacttgtc     6300

catcttctgg attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac     6360

atgctaatca ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct     6420

gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta     6480

taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata taaatattaa     6540

tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg     6600

aattcgatat caagcttatc gataccgtcg agggggggcc cggtaccggc gcgccgttct     6660

atagtgtcac ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg     6720

ttctaacgac aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata     6780

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     6840

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     6900

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     6960

ggttaatgtc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7020

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7080

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7140

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     7200

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7260

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7320

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7380

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     7440

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     7500

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     7560

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     7620

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     7680

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     7740

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     7800

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     7860

ttaatgcagg ttgatcagat ctcgatcccg cgaaattaat acgactcact atagggagac     7920

cacaacggtt tccctctaga aataattttg tttaacttta agaaggagat atacccatgg     7980

aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg     8040

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag     8100

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt     8160

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg     8220

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag     8280

acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct atggatgcga     8340

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg     8400

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact     8460

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga     8520

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca     8580

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt     8640

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta     8700

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc     8760

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca     8820

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg     8880

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg     8940

tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat     9000

agtgaggtac agcttggatc gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg     9060

ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga     9120

ggggtttttt gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac           9174


<210>  507
<211>  6113
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1192A

<400>  507
caagtagttc tagtcttaat acaaatgtca aatggcacaa gtgagatttt gaatttctga       60

tgttgtaaaa atctcaggac atgaatacta ttgggaagca attattcata cttcaccaat      120

ccaaactgac ccaaaattct caaatcacat gaaagcaaaa atgcatataa cacgaagaat      180

aagaagaaga ggaactaacc tggggtttcg atgattaaag cgttgttgtt gatgatgaaa      240

acgatgatta tggagagaaa ttgttgttga atggtgaaat tgttatagaa agagaacgaa      300

gatagagaaa aagatatata gatttttcaa ggctcaaacc ctaaaatcac catgagagag      360

aacaaagatt gagaaaccta caaccactat gagagagaat gagcagaaca gaagcgtgag      420

atagagaacg agagttaagg tgcgagagga cacgaagaac aaaaggtgtg agagaaagaa      480

caaaggagcc tacggtgtga gatgagagaa tttgaaattc ttaccattta ggtggaattt      540

caattctaca attttattct attaaaatta ttttaaaaaa tgatgtcatt ttaaattctt      600

taaaatctca tatccaacaa ctgaattatg atagaggtat ttcaaattca cttaaaaaaa      660

ttatcttatt taaatacccc atccaaacat agcgaaatgt tcatgagaag gatcaagtgg      720

tttggaaaca tagtactaat ggtgtttata cagttcatgg aatccttgat agataattta      780

aaggttgctg gaaattggat gaaggtgtgg agattaaata ttcttccaaa aataaagcgt      840

tttatttgga gagtgttgtg tggttgtctc ccctgtaggc aaaagcttcg atgtaaagga      900

gttcaatgtc caataaccta tgctttctat ccctcgatta ttgaaaatga atgacacatt      960

ttatttggtt gaaatcaaga aataagcatg tggcaagcaa cgggtatttg acaattcata     1020

gaacaaaagg tgaatgcagc aaaagaatta atgaactcct tttcgatcta cttggatcac     1080

tacatggaga tattatcaac aaatttgatg ttactttatg gagcagttgg aattcttgga     1140

atgacaagat atgaaatgaa cataccaacc ctcctcttgt ttctgtttcg gtttctatgc     1200

agtattttgt tgaatggcaa agtgcaaggt aatatgctcc tcaacatcaa ttaacaaatg     1260

ttcatgacat ctcttaccag ctccaacttg gggacgtttg acaaacacca ccgtcaagtt     1320

tccttaaatg caacattaat gttgctcatt tcaaggagga gaatagtttt ggtgtcggca     1380

tgatactcca tcaaggaaga ttcgtcaaag ctcactcacg ttttcgacat gggtcgacat     1440

gggttacctg acccaaaggc tgaggcttag gcttgggttt gcttcaagta ttgatctggg     1500

cccagactat tggtttacat aatatcattt ttgaaaacct aacatctaaa actcaaggtt     1560

gtttagaggt gcgccattcc aaaataagat tatcctattt gtgcatgaat gcgaccaact     1620

atctcctgtt tcagcattat aaagtataaa caacaaactt ctttaatcaa gggactaaaa     1680

gatattggac atacaagcta aaagtgatag aatttgagaa aacaaatatt gacaacaata     1740

ttcaagagga cactaaaaca taattctcaa attttttttg tttatttaaa ataaagtggt     1800

tcattaggta gctccgggtg attgcggtta catcatgtac ggaaaaataa ttctaatcct     1860

tgatttaaat ttgaacttga ctatttattt attctttatt tcattttgta aatcatttta     1920

tgtatctcct ggcaagcaat tttatccacc ttgcaccaac accttcgggt tccataatca     1980

aaccacctta acttcacacc atgctgtaac tcacaccgcc cagcatctcc aatgtgaaag     2040

aagctaaaat ttaataaaca atcatacgaa gcagtgacaa aataccagat ggtattaatg     2100

cttcgataaa attaattgga aagtataaaa tggtagaaaa taataaatta taattaattt     2160

aagtaagata aaaaataatt aaaaactaaa atgttaaaat tttaaaaaaa ttattttaaa     2220

taatatttaa aaacattaaa aatcatttta aaaaatttat ttatagaaca attaaataaa     2280

tatttcagct aataaaaaac aaaagcttac ctagccttag aagacaactt gtccaacaat     2340

tagatgatac ccattgccct tacgttttct ttaacatcaa ttattgtttt tgtcaacaag     2400

ctatctttta gttttatttt attggtaaaa aatatgtcgc cttcaagttg catcatttaa     2460

cacatctcgt cattagaaaa ataaaactct tccctaaacg attagtagaa aaaatcattc     2520

gataataaat aagaaagaaa aattagaaaa aaataacttc attttaaaaa aatcattaag     2580

gctatatttt ttaaatgact aattttatat agactgtaac taaaagtata caatttatta     2640

tgctatgtat cttaaagaat tacttataaa aatctacgga agaatatctt acaaagtgaa     2700

aaacaaatga gaaagaattt agtgggatga ttatgatttt atttgaaaat tgaaaaaata     2760

attattaaag actttagtgg agtaagaaag ctttcctatt agtcttttct tatccataaa     2820

aaaaaaaaaa aaaatctagc gtgacagctt ttccatagat tttaataatg taaaatactg     2880

gtagcagccg accgttcagg taatggacac tgtggtccta acttgcaacg ggtgcgggcc     2940

caatttaata acgccgtggt aacggataaa gccaagcgtg aagcggtgaa ggtacatctc     3000

tgactccgtc aagattacga aaccgtcaac tacgaaggac tccccgaaat atcatctgtg     3060

tcataaacac caagtcacac catacatggg cacgcgtcac aatatgattg gagaacggtt     3120

ccaccgcata tgctataaaa tgcccccaca cccctcgacc ctaatcgcac ttcaattgca     3180

atcaaattag ttcattctct ttgcgcagtt ccctacctct cctttcaagg ttcgtagatt     3240

tcttccgttt ttttttcttc ttctttattg tttgttctac atcagcatga tgttgatttg     3300

attgtgtttt ctatcgtttc atcgattata aattttcata atcagaagat tcagctttta     3360

ttaatgcaag aacgtcctta attgatgatt ttataaccgt aaattaggtc taattagagt     3420

ttttttcata aagattttca gatccgttta caacaagcct taattgttga ttctgtagtc     3480

gtagattaag gtttttttca tgaactactt cagatccgtt aaacaacagc cttatttgtt     3540

gatacttcag tcgtttttca agaaattgtt cagatccgtt gataaaagcc ttattcgttg     3600

attctgtatg gtatttcaag agatattgct caggtccttt agcaactacc ttatttgttg     3660

attctgtggc catagattag gatttttttt cacgaaattg cttcttgaaa ttacgtgatg     3720

gattttgatt ctgatttatc ttgtgattgt tgactctaca gatggcccaa gtgagcagag     3780

tgcacaatct tgctcaaagc actcaaattt ttggccattc ttccaactcc aacaaactca     3840

aatcggtgaa ttcggtttca ttgaggccac gcctttgggg ggcctcaaaa tctcgcatcc     3900

cgatgcataa aaatggaagc tttatgggaa attttaatgt ggggaaggga aattccggcg     3960

tgtttaaggt ttctgcatcg gtcgccgccg cagagaagcc gtcaacgtcg ccggagatcg     4020

tgttggaacc catcaaagac ttctcgggta ccatcacatt gccagggtcc aagtctctgt     4080

ccaatcgaat tttgcttctt gctgctctct ctgaggtgaa gtttatttat ttatttattt     4140

gtttgtttgt tgttgggtgt gggaatagga gtttgatgtg tagagtggat tttgaatatt     4200

tgattttttt ttgtattatt ctgtgaaaat gaagcatcat gtcccatgaa agaaatggac     4260

acgaaattaa gtggcttatg atgtgaaatg aggatagaaa tgtgtgtagg gttttttaat     4320

gggtagcaat aagcatattc aatatctgga ttgatttgga cgtttctgta taaaggagta     4380

tgctagcaat gtgttaatgt atggcttgct aaaatactcc taaaaatcaa gtgggagtag     4440

tatacatatc tacagcaaat gtattaggtg aggcatttgg cttctctatt gtaaggaaca     4500

aataatatca gttaatgtga aaatcaatgg ttgatattcc aatacattca tgatgtgtta     4560

tttatatgta cctaatattg actgttgttt ttctccgcaa tgaccaagat tatttatttt     4620

atcctctaaa gtgactaatt gagttgctta ctttagagaa gttggaccca ttaggtgaga     4680

gcgtgggggg aactaatctt gaatatacaa tctgagtctt gattatccaa gtatggttgt     4740

atgaacaatg ttagctctag aagataaacc ctcccccaaa acacaaatta gaatgacatt     4800

tcaagttcca tgtatgtcac tttcattcta ttatttttac aacttttagt tacttaacag     4860

atgtcttgtt cagcataaat tataatttat tctgtttttt tttagggaac aactgttgta     4920

gacaacttgt tgtatagtga ggatattcat tacatgcttg gtgcattaag gacccttgga     4980

ctgcgtgtgg aagatgacaa aacaaccaaa caagcaattg ttgaaggctg tgggggattg     5040

tttcccacta gtaaggaatc taaagatgaa atcaatttat tccttggaaa tgctggtatt     5100

gcaatgagat ctttgacagc agctgttgtt gctgcaggtg gaaatgcaag gtctgttttt     5160

tttttttttg ttcagcataa tctttgaatt gttcctcgta taactaatca caacagagta     5220

cgtgttcttc ttcctgttat aatctaaaaa tctcatccag attagtcatc ctttcttctt     5280

aaaaggaacc tttaattatc aatgtattta tttaatattt aaattagctt gtcaaagtct     5340

agcatataca tattttgatt atattctgag aaatgcacct gagggtgttc ctcatgatct     5400

acttcaacct ctgttattat tagattttct atcatgatta ctggtttgag tctctaagta     5460

gaccatcttg atgttcaaaa tatttcagct acgtacttga tggggtgccc cgaatgagag     5520

agaggccaat tggggatttg gttgctggtc ttaagcaact tggtgcagat gttgattgct     5580

ttcttggcac aaactgtcca cctgttcgtg taaatgggaa gggaggactt cctggcggaa     5640

aggtatggtt tggatttcat ttagaataag gtggagtaac tttcctggat caaaattcta     5700

atttaagaag cctccctgtt ttcctctctt tagaataaga ctaagggtag gtttaggagt     5760

tgggttttgg agagaaatgg aagggagagc aatttttttc ttcttctaat aaatattctt     5820

taatttgata cattttttaa gtaaaagaat ataaagatag attagcataa cttaatgttt     5880

taatctttta tttattttta taaatattat atacctgtct atttaaaaat caaatatttg     5940

tcctccattc cctttccctt caaaacctca gttccaaata taccgtagtt gaattatatt     6000

ttggaaggcc tattggttgg agacttttcc ttttcagaga ttatccctca cctttattat     6060

agcctttcta tttttaaact tcatatagac gccattcttg gggcggccgc gat            6113


<210>  508
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, soy1-F4

<400>  508
tcaataatac tactctctta gacaccaaac aa                                     32


<210>  509
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer, soy1-R4

<400>  509
caaggaaaat gaatgatggc ttt                                               23


<210>  510
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>   probe, soy1-T3(FAM-MGB)

<400>  510
ccttcccaaa ctataatc                                                     18


<210>  511
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>   WOL1005, Forward_primer

<400>  511
aaatgttatc agaggaacat gagctgc                                           27


<210>  512
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  WOL1006, Reverse_primer

<400>  512
attatttttc cgtacatgat gtaaccgc                                          28


<210>  513
<211>  438
<212>  DNA
<213>  Cauliflower mozaic virus

<400>  513
cccatggagt caaagattca aatagaggac ctaacagaac tcgccgtaaa gactggcgaa       60

cagttcatac agagtctctt acgactcaat gacaagaaga aaatcttcgt caacatggtg      120

gagcacgaca cgcttgtcta ctccaaaaat atcaaagata cagtctcaga agaccaaagg      180

gcaattgaga cttttcaaca aagggtaata tccggaaacc tcctcggatt ccattgccca      240

gctatctgtc actttattgt gaagatagtg gaaaaggaag gtggctccta caaatgccat      300

cattgcgata aaggaaaggc catcgttgaa gatgcctctg ccgacagtgg tcccaaagat      360

ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac gtcttcaaag      420

caagtggatt gatgtgat                                                    438


<210>  514
<211>  19
<212>  DNA
<213>  Cauliflower mozaic virus

<400>  514
gtctcagaag accaaaggg                                                    19


<210>  515
<211>  25
<212>  DNA
<213>  Cauliflower mozaic virus

<400>  515
tgccatcatt gcgataaagg aaagg                                             25


<210>  516
<211>  20
<212>  DNA
<213>  Cauliflower mozaic virus

<400>  516
gatgcctctg ccgacagtgg                                                   20


<210>  517
<211>  3708
<212>  DNA
<213>  Zea mays

<400>  517
ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa gtcgctttcc       60

aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc ttgctgcgct      120

gccctgtctc actgctacct aaatgttttg cctgtcgaat accatggatt ctcggtgtaa      180

tccatctcac gatcagatgc accgcatgtc gcatgcctag ctctctctaa tttgtctagt      240

agtttgtata cggattaaga ttgataaatc ggtaccgcaa aagctaggtg taaataaaca      300

ctacaaaatt ggatgttccc ctatcggcct gtactcggct actcgttctt gtgatggcat      360

gttatttctt cttggtgttt ggtgaactcc cttatgaaat ttgggcgcaa agaaatcgcc      420

ctcaagggtt gatcttatgc catcgtcatg ataaacagtg aagcacggat gatcctttac      480

gttgttttta acaaactttg tcagaaaact agcaatgtta acttcttaat gatgatttca      540

caacaaaaaa ggtaaccttg ctactaacat aacaaaagac ttgttgctta ttaattatat      600

gtttttttaa tctttgatca ggggacaaca gtggttgata acctgttgaa cagtgaggat      660

gtccactaca tgctcggggc cttgaggact cttggtctct ctgtcgaagc ggacaaagct      720

gccaaaagag ctgtagttgt tggctgtggt ggaaagttcc cagttgagga tgctagagag      780

gaagtgcagc tcttcttggg gaatgctgga atcgcaatgc ggtcattgac agcagctgtt      840

actgctgctg gtggaaatgc aacgtatgtt tcctctctct ctctacaata cttgttggag      900

ttagtatgaa acccatgtgt atgtctagtg gcttatggtg tattggtttt tgaacttcag      960

ttacgtgctt gatggagtac caagaatgag ggagagaccc attggcgact tggttgtcgg     1020

attgaagcag cttggtgcag atgttgattg tttccttggc actgactgcc cacctgttcg     1080

tgtcaatgga atcggagggc tacctggtgg caaggttagt tactaagggc cacatgttac     1140

attcttctgt aaatggtaca actattgtcg agcttttgca tttgtaagga aaacattgat     1200

tgatctgaat ttgatgctac accacaaaat atctacaaat ggtcatccct aactagcaaa     1260

ccatgtctcc attaagctca atgaagtaat acttggcatg tgtttatcaa cttaatttcc     1320

atcttctggg gtattgcctg ttttctagtc taatagcatt tgtttttaga attagctctt     1380

acaactgtta tgttctacag gtcaagctgt ctggctccat cagcagtcag tacttgagtg     1440

ccttgctgat ggctgctcct ttggctcttg gggatgtgga gattgaaatc attgataaat     1500

taatctccat tccctacgtc gaaatgacat tgagattgat ggagcgtttt ggtgtgaaag     1560

cagagcattc tgatagctgg gacagattct acattaaggg aggtcaaaaa tacaagtaag     1620

ctctgtaatg tatttcacta ctttgatgcc aatgtttcag ttttcagttt tccaaacagt     1680

cgcatcaata tttgaataga tgcactgtag aaaaaaatca ttgcagggaa aaactagtac     1740

tgagtatttt gactgtaaat tatttaacca gtcggaatat agtcagtcta ttggagtcaa     1800

gagcgtgaac cgaaatagcc agttaattat cccattatac agaggacaac catgtatact     1860

attgaaactt ggtttaagag aatctaggta gctggactcg tagctgcttg gcatggatac     1920

cttcttatct ttaggaaaag acacttgatt ttttttctgt ggccctctat gatgtgtgaa     1980

cctgcttctc tattgcttta gaaggatata tctatgtcgt tatgcaacat gcttccctta     2040

gtcatttgta ctgaaatcag tttcataagt tcgttagtgg ttccctaaac gaaaccttgt     2100

ttttctttgc aatcaacagg tcccctaaaa atgcctatgt tgaaggtgat gcctcaagcg     2160

caagctattt cttggctggt gctgcaatta ctggagggac tgtgactgtg gaaggttgtg     2220

gcaccaccag tttgcaggta aagatttctt ggctggtgct acgataactg cttttgtctt     2280

tttggtttca gcattgttct cagagtcact aaataacatt atcatctgca aacgtcaaat     2340

agacatactt aggtgaatgg atattcatgt aaccgtttcc ttacaaattt gctgaaacct     2400

cagggtgatg tgaagtttgc tgaggtactg gagatgatgg gagcgaaggt tacatggacc     2460

gagactagcg taactgttac tggcccaccg cgggagccat ttgggaggaa acacctcaag     2520

gcgattgatg tcaacatgaa caagatgcct gatgtcgcca tgactcttgc tgtggttgcc     2580

ctctttgccg atggcccgac agccatcaga gacggtaaaa cattctcagc cctacaacca     2640

tgcctcttct acatcactac ttgacaagac taaaaactat tggctcgttg gcagtggctt     2700

cctggagagt aaaggagacc gagaggatgg ttgcgatccg gacggagcta accaaggtaa     2760

ggctacatac ttcacatgtc tcacgtcgtc tttccatagc tcgctgcctc ttagcggctt     2820

gcctgcggtc gctccatcct cggttgctgt ctgtgttttc cacagctggg agcatctgtt     2880

gaggaagggc cggactactg catcatcacg ccgccggaga agctgaacgt gacggcgatc     2940

gacacgtacg acgaccacag gatggccatg gccttctccc ttgccgcctg tgccgaggtc     3000

cccgtgacca tccgggaccc tgggtgcacc cggaagacct tccccgacta cttcgatgtg     3060

ctgagcactt tcgtcaagaa ttaataaagc gtgcgatact accacgcagc ttgattgaag     3120

tgataggctt gtgctgagga aatacatttc ttttgttctg ttttttctct ttcacgggat     3180

taagttttga gtctgtaacg ttagttgttt gtagcaagtt tctatttcgg atcttaagtt     3240

tgtgcactgt aagccaaatt tcatttcaag agtggttcgt tggaataata agaataataa     3300

attacgtttc agtggctgtc aagcctgctg ctacgtttta ggagatggca ttagacattc     3360

atcatcaaca acaataaaac cttttagcct caaacaataa tagtgaagtt attttttagt     3420

cctaaacaag ttgcattagg atatagttaa aacacaaaag aagctaaagt tagggtttag     3480

acatgtggat attgttttcc atgtatagta tgttctttct ttgagtctca tttaactacc     3540

tctacacata ccaactttag ttttttttct acctcttcat gttactatgg tgccttctta     3600

tcccactgag cattggtata tttagaggtt tttgttgaac atgcctaaat catctcaatc     3660

aacgatggac aatcttttct tcgattgagc tgaggtacgt catctaga                  3708


<210>  518
<211>  3714
<212>  DNA
<213>  Zea mays

<400>  518
ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa gtcgctttcc       60

aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc ttgctgcgct      120

gccctgtctc actgctacct aaatgttttg cctgtcgaat accatggatt ctcggtgtaa      180

tccatatctg cacgatcaga tatgcaccgc atgtcgcata tctgagctct ctctaatttg      240

tctagtagtt tgtatacgga ttaagattga taaatcggta ccgcaaaagc taggtgtaaa      300

taaacactac aaaattggat gttcccctat cggcctgtac tcggctactc gttcttgtga      360

tggcatgtta tttcttcttg gtgtttggtg aactccctta tgaaatttgg gcgcaaagaa      420

atcgccctca agggttgatc ttatgccatc gtcatgataa acagtgaagc acggatgatc      480

ctttacgttg tttttaacaa actttgtcag aaaactagca atgttaactt cttaatgatg      540

atttcacaac aaaaaaggta accttgctac taacataaca aaagacttgt tgcttattaa      600

ttatatgttt ttttaatctt tgatcagggg acaacagtgg ttgataacct gttgaacagt      660

gaggatgtcc actacatgct cggggccttg aggactcttg gtctctctgt cgaagcggac      720

aaagctgcca aaagagctgt agttgttggc tgtggtggaa agttcccagt tgaggatgct      780

aaagaggaag tgcagctctt cttggggaat gctggaatcg caatgcggtc attgacagca      840

gctgttactg ctgctggtgg aaatgcaacg tatgtttcct ctctctctct acaatacttg      900

ttggagttag tatgaaaccc atgtgtatgt ctagtggctt atggtgtatt ggtttttgaa      960

cttcagttac gtgcttgatg gagtaccaag aatgagggag agacccattg gcgacttggt     1020

tgtcggattg aagcagcttg gtgcagatgt tgattgtttc cttggcactg actgcccacc     1080

tgttcgtgtc aatggaatcg gagggctacc tggtggcaag gttagttact aagggccaca     1140

tgttacattc ttctgtaaat ggtacaacta ttgtcgagct tttgcatttg taaggaaaac     1200

attgattgat ctgaatttga tgctacacca caaaatatct acaaatggtc atccctaact     1260

agcaaaccat gtctccatta agctcaatga agtaatactt ggcatgtgtt tatcaactta     1320

atttccatct tctggggtat tgcctgtttt ctagtctaat agcatttgtt tttagaatta     1380

gctcttacaa ctgttatgtt ctacaggtca agctgtctgg ctccatcagc agtcagtact     1440

tgagtgcctt gctgatggct gctcctttgg ctcttgggga tgtggagatt gaaatcattg     1500

ataaattaat ctccattccc tacgtcgaaa tgacattgag attgatggag cgttttggtg     1560

tgaaagcaga gcattctgat agctgggaca gattctacat taagggaggt caaaaataca     1620

agtaagctct gtaatgtatt tcactacttt gatgccaatg tttcagtttt cagttttcca     1680

aacagtcgca tcaatatttg aatagatgca ctgtagaaaa aaatcattgc agggaaaaac     1740

tagtactgag tattttgact gtaaattatt taaccagtcg gaatatagtc agtctattgg     1800

agtcaagagc gtgaaccgaa atagccagtt aattatccca ttatacagag gacaaccatg     1860

tatactattg aaacttggtt taagagaatc taggtagctg gactcgtagc tgcttggcat     1920

ggataccttc ttatctttag gaaaagacac ttgatttttt ttctgtggcc ctctatgatg     1980

tgtgaacctg cttctctatt gctttagaag gatatatcta tgtcgttatg caacatgctt     2040

cccttagtca tttgtactga aatcagtttc ataagttcgt tagtggttcc ctaaacgaaa     2100

ccttgttttt ctttgcaatc aacaggtccc ctaaaaatgc ctatgttgaa ggtgatgcct     2160

caagcgcaag ctatttcttg gctggtgctg caattactgg agggactgtg actgtggaag     2220

gttgtggcac caccagtttg caggtaaaga tttcttggct ggtgctacga taactgcttt     2280

tgtctttttg gtttcagcat tgttctcaga gtcactaaat aacattatca tctgcaaacg     2340

tcaaatagac atacttaggt gaatggatat tcatgtaacc gtttccttac aaatttgctg     2400

aaacctcagg gtgatgtgaa gtttgctgag gtactggaga tgatgggagc gaaggttaca     2460

tggaccgaga ctagcgtaac tgttactggc ccaccgcggg agccatttgg gaggaaacac     2520

ctcaaggcga ttgatgtcaa catgaacaag atgcctgatg tcgccatgac tcttgctgtg     2580

gttgccctct ttgccgatgg cccgacagcc atcagagacg gtaaaacatt ctcagcccta     2640

caaccatgcc tcttctacat cactacttga caagactaaa aactattggc tcgttggcag     2700

tggcttcctg gagagtaaag gagaccgaga ggatggttgc gatccggacg gagctaacca     2760

aggtaaggct acatacttca catgtctcac gtcgtctttc catagctcgc tgcctcttag     2820

cggcttgcct gcggtcgctc catcctcggt tgctgtctgt gttttccaca gctgggagca     2880

tctgttgagg aagggccgga ctactgcatc atcacgccgc cggagaagct gaacgtgacg     2940

gcgatcgaca cgtacgacga ccacaggatg gccatggcct tctcccttgc cgcctgtgcc     3000

gaggtccccg tgaccatccg ggaccctggg tgcacccgga agaccttccc cgactacttc     3060

gatgtgctga gcactttcgt caagaattaa taaagcgtgc gatactacca cgcagcttga     3120

ttgaagtgat aggcttgtgc tgaggaaata catttctttt gttctgtttt ttctctttca     3180

cgggattaag ttttgagtct gtaacgttag ttgtttgtag caagtttcta tttcggatct     3240

taagtttgtg cactgtaagc caaatttcat ttcaagagtg gttcgttgga ataataagaa     3300

taataaatta cgtttcagtg gctgtcaagc ctgctgctac gttttaggag atggcattag     3360

acattcatca tcaacaacaa taaaaccttt tagcctcaaa caataatagt gaagttattt     3420

tttagtccta aacaagttgc attaggatat agttaaaaca caaaagaagc taaagttagg     3480

gtttagacat gtggatattg ttttccatgt atagtatgtt ctttctttga gtctcattta     3540

actacctcta cacataccaa ctttagtttt ttttctacct cttcatgtta ctatggtgcc     3600

ttcttatccc actgagcatt ggtatattta gaggtttttg ttgaacatgc ctaaatcatc     3660

tcaatcaacg atggacaatc ttttcttcga ttgagctgag gtacgtcatc taga           3714


<210>  519
<211>  3708
<212>  DNA
<213>  Zea mays

<400>  519
ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa gtcgctttcc       60

aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc ttgctgcgct      120

gccctgtctc actgctacct aaatgttttg cctgtcgaat accatggatt ctcggtgtaa      180

tccatctcac gatcagatgc accgcatgtc gcatgcctag ctctctctaa tttgtctagt      240

agtttgtata cggattaaga ttgataaatc ggtaccgcaa aagctaggtg taaataaaca      300

ctacaaaatt ggatgttccc ctatcggcct gtactcggct actcgttctt gtgatggcat      360

gttatttctt cttggtgttt ggtgaactcc cttatgaaat ttgggcgcaa agaaatcgcc      420

ctcaagggtt gatcttatgc catcgtcatg ataaacagtg aagcacggat gatcctttac      480

gttgttttta acaaactttg tcagaaaact agcaatgtta acttcttaat gatgatttca      540

caacaaaaaa ggtaaccttg ctactaacat aacaaaagac ttgttgctta ttaattatat      600

gtttttttaa tctttgatca ggggacaaca gtggttgata acctgttgaa cagtgaggat      660

gtccactaca tgctcggggc cttgaggact cttggtctct ctgtcgaagc ggacaaagct      720

gccaaaagag ctgtagttgt tggctgtggt ggaaagttcc cagttgagga tgctagaaag      780

gaagtgcagc tcttcttggg gaatgctgga atcgcaatgc ggtcattgac agcagctgtt      840

actgctgctg gtggaaatgc aacgtatgtt tcctctctct ctctacaata cttgttggag      900

ttagtatgaa acccatgtgt atgtctagtg gcttatggtg tattggtttt tgaacttcag      960

gtacgtgctt gatggagtac caagaatgag ggagagaccc attggcgact tggttgtcgg     1020

attgaagcag cttggtgcag atgttgattg tttccttggc actgactgcc cacctgttcg     1080

tgtcaatgga atcggagggc tacctggtgg caaggttagt tactaagggc cacatgttac     1140

attcttctgt aaatggtaca actattgtcg agcttttgca tttgtaagga aaacattgat     1200

tgatctgaat ttgatgctac accacaaaat atctacaaat ggtcatccct aactagcaaa     1260

ccatgtctcc attaagctca atgaagtaat acttggcatg tgtttatcaa cttaatttcc     1320

atcttctggg gtattgcctg ttttctagtc taatagcatt tgtttttaga attagctctt     1380

acaactgtta tgttctacag gtcaagctgt ctggctccat cagcagtcag tacttgagtg     1440

ccttgctgat ggctgctcct ttggctcttg gggatgtgga gattgaaatc attgataaat     1500

taatctccat tccctacgtc gaaatgacat tgagattgat ggagcgtttt ggtgtgaaag     1560

cagagcattc tgatagctgg gacagattct acattaaggg aggtcaaaaa tacaagtaag     1620

ctctgtaatg tatttcacta ctttgatgcc aatgtttcag ttttcagttt tccaaacagt     1680

cgcatcaata tttgaataga tgcactgtag aaaaaaatca ttgcagggaa aaactagtac     1740

tgagtatttt gactgtaaat tatttaacca gtcggaatat agtcagtcta ttggagtcaa     1800

gagcgtgaac cgaaatagcc agttaattat cccattatac agaggacaac catgtatact     1860

attgaaactt ggtttaagag aatctaggta gctggactcg tagctgcttg gcatggatac     1920

cttcttatct ttaggaaaag acacttgatt ttttttctgt ggccctctat gatgtgtgaa     1980

cctgcttctc tattgcttta gaaggatata tctatgtcgt tatgcaacat gcttccctta     2040

gtcatttgta ctgaaatcag tttcataagt tcgttagtgg ttccctaaac gaaaccttgt     2100

ttttctttgc aatcaacagg tcccctaaaa atgcctatgt tgaaggtgat gcctcaagcg     2160

caagctattt cttggctggt gctgcaatta ctggagggac tgtgactgtg gaaggttgtg     2220

gcaccaccag tttgcaggta aagatttctt ggctggtgct acgataactg cttttgtctt     2280

tttggtttca gcattgttct cagagtcact aaataacatt atcatctgca aacgtcaaat     2340

agacatactt aggtgaatgg atattcatgt aaccgtttcc ttacaaattt gctgaaacct     2400

cagggtgatg tgaagtttgc tgaggtactg gagatgatgg gagcgaaggt tacatggacc     2460

gagactagcg taactgttac tggcccaccg cgggagccat ttgggaggaa acacctcaag     2520

gcgattgatg tcaacatgaa caagatgcct gatgtcgcca tgactcttgc tgtggttgcc     2580

ctctttgccg atggcccgac agccatcaga gacggtaaaa cattctcagc cctacaacca     2640

tgcctcttct acatcactac ttgacaagac taaaaactat tggctcgttg gcagtggctt     2700

cctggagagt aaaggagacc gagaggatgg ttgcgatccg gacggagcta accaaggtaa     2760

ggctacatac ttcacatgtc tcacgtcgtc tttccatagc tcgctgcctc ttagcggctt     2820

gcctgcggtc gctccatcct cggttgctgt ctgtgttttc cacagctggg agcatctgtt     2880

gaggaagggc cggactactg catcatcacg ccgccggaga agctgaacgt gacggcgatc     2940

gacacgtacg acgaccacag gatggccatg gccttctccc ttgccgcctg tgccgaggtc     3000

cccgtgacca tccgggaccc tgggtgcacc cggaagacct tccccgacta cttcgatgtg     3060

ctgagcactt tcgtcaagaa ttaataaagc gtgcgatact accacgcagc ttgattgaag     3120

tgataggctt gtgctgagga aatacatttc ttttgttctg ttttttctct ttcacgggat     3180

taagttttga gtctgtaacg ttagttgttt gtagcaagtt tctatttcgg atcttaagtt     3240

tgtgcactgt aagccaaatt tcatttcaag agtggttcgt tggaataata agaataataa     3300

attacgtttc agtggctgtc aagcctgctg ctacgtttta ggagatggca ttagacattc     3360

atcatcaaca acaataaaac cttttagcct caaacaataa tagtgaagtt attttttagt     3420

cctaaacaag ttgcattagg atatagttaa aacacaaaag aagctaaagt tagggtttag     3480

acatgtggat attgttttcc atgtatagta tgttctttct ttgagtctca tttaactacc     3540

tctacacata ccaactttag ttttttttct acctcttcat gttactatgg tgccttctta     3600

tcccactgag cattggtata tttagaggtt tttgttgaac atgcctaaat catctcaatc     3660

aacgatggac aatcttttct tcgattgagc tgaggtacgt catctaga                  3708


<210>  520
<211>  464
<212>  PRT
<213>  zea mays

<400>  520

Met Gln Leu Asp Leu Asn Val Ala Glu Ala Pro Pro Pro Val Glu Met 
1               5                   10                  15      


Glu Ala Ser Asp Ser Gly Ser Ser Val Leu Asn Ala Ser Glu Ala Ala 
            20                  25                  30          


Ser Ala Gly Gly Ala Pro Ala Pro Ala Glu Glu Gly Ser Ser Ser Thr 
        35                  40                  45              


Pro Ala Val Leu Glu Phe Ser Ile Leu Ile Arg Ser Asp Ser Asp Ala 
    50                  55                  60                  


Ala Gly Ala Asp Glu Asp Glu Asp Ala Thr Pro Ser Pro Pro Pro Arg 
65                  70                  75                  80  


His Arg His Gln His Gln Gln Gln Leu Val Thr Arg Glu Leu Phe Pro 
                85                  90                  95      


Ala Gly Ala Gly Pro Pro Ala Pro Thr Pro Arg His Trp Ala Glu Leu 
            100                 105                 110         


Gly Phe Phe Arg Ala Asp Leu Gln Gln Gln Gln Ala Pro Gly Pro Arg 
        115                 120                 125             


Ile Val Pro His Pro His Ala Ala Pro Pro Pro Ala Lys Lys Ser Arg 
    130                 135                 140                 


Arg Gly Pro Arg Ser Arg Ser Ser Gln Tyr Arg Gly Val Thr Phe Tyr 
145                 150                 155                 160 


Arg Arg Thr Gly Arg Trp Glu Ser His Ile Trp Asp Cys Gly Lys Gln 
                165                 170                 175     


Val Tyr Leu Gly Gly Phe Asp Thr Ala His Ala Ala Ala Arg Ala Tyr 
            180                 185                 190         


Asp Arg Ala Ala Ile Lys Phe Arg Gly Val Asp Ala Asp Ile Asn Phe 
        195                 200                 205             


Asn Leu Ser Asp Tyr Glu Asp Asp Met Lys Gln Met Gly Ser Leu Ser 
    210                 215                 220                 


Lys Glu Glu Phe Val His Val Leu Arg Arg Gln Ser Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Gly Ser Ser Arg Tyr Arg Gly Val Thr Leu His Lys Cys Gly Arg 
                245                 250                 255     


Trp Glu Ala Arg Met Gly Gln Phe Leu Gly Lys Lys Tyr Ile Tyr Leu 
            260                 265                 270         


Gly Leu Phe Asp Ser Glu Val Glu Ala Ala Arg Ala Tyr Asp Lys Ala 
        275                 280                 285             


Ala Ile Lys Cys Asn Gly Arg Glu Ala Val Thr Asn Phe Glu Pro Ser 
    290                 295                 300                 


Thr Tyr His Gly Glu Leu Pro Thr Glu Val Ala Asp Val Asp Leu Asn 
305                 310                 315                 320 


Leu Ser Ile Ser Gln Pro Ser Pro Gln Arg Asp Lys Asn Ser Cys Leu 
                325                 330                 335     


Gly Leu Gln Leu His His Gly Pro Phe Glu Gly Ser Glu Leu Lys Lys 
            340                 345                 350         


Thr Lys Ile Asp Asp Ala Pro Ser Glu Leu Pro Gly Arg Pro Arg Gln 
        355                 360                 365             


Leu Ser Pro Leu Val Ala Glu His Pro Pro Ala Trp Pro Ala Gln Pro 
    370                 375                 380                 


Pro His Pro Phe Phe Val Phe Thr Asn His Glu Met Ser Ala Ser Gly 
385                 390                 395                 400 


Asp Leu His Arg Arg Pro Ala Gly Ala Val Pro Ser Trp Ala Trp Gln 
                405                 410                 415     


Val Ala Ala Ala Ala Pro Pro Pro Ala Ala Leu Pro Ser Ser Ala Ala 
            420                 425                 430         


Ala Ser Ser Gly Phe Ser Asn Thr Ala Thr Thr Ala Ala Thr Thr Ala 
        435                 440                 445             


Pro Ser Ala Ser Ser Leu Arg Tyr Cys Pro Pro Pro Pro Pro Pro Ser 
    450                 455                 460                 


<210>  521
<211>  1413
<212>  DNA
<213>  Zea mays

<400>  521
atgcagttgg atctgaacgt ggccgaggcg ccgccgccgg tggagatgga ggcgagcgac       60

tcggggtcgt cggtgctgaa cgcgtcggaa gcggcgtcgg cgggcggcgc gcccgcgccg      120

gcggaggagg gatctagctc aacgccggcc gtgctggagt tcagcatcct catccggagc      180

gatagcgacg cggccggcgc ggacgaggac gaggacgcca cgccatcgcc tcctcctcgc      240

caccgccacc agcaccagca gcagctcgtg acccgcgagc tgttcccggc cggcgccggt      300

ccgccggccc cgacgccgcg gcattgggcc gagctcggct tcttccgcgc cgacctgcag      360

cagcaacagg cgccgggccc caggatcgtg ccgcacccac acgccgcgcc gccgccggcc      420

aagaagagcc gccgcggccc gcgctcccgc agctcgcagt accgcggcgt caccttctac      480

cgccgcacag gccgctggga gtcccacatc tgggattgcg gcaagcaggt gtacctaggt      540

ggattcgaca ccgctcacgc cgctgcaagg gcgtacgacc gggcggcgat caagttccgc      600

ggcgtcgacg ccgacatcaa cttcaacctc agcgactacg aggacgacat gaagcagatg      660

gggagcctgt ccaaggagga gttcgtgcac gtcctgcgcc gtcagagcac cggcttctcg      720

agaggcagct ccaggtacag aggcgtcacc ctgcacaagt gcggccgctg ggaggcgcgc      780

atggggcagt tcctcggcaa gaagtacata taccttgggc tattcgacag cgaagtagag      840

gctgcaagag cctacgacaa ggccgccatc aaatgcaatg gcagagaggc cgtgacgaac      900

ttcgagccga gcacgtatca cggggagctg ccgactgaag ttgctgatgt cgatctgaac      960

ctgagcatat ctcagccgag cccccaaaga gacaagaaca gctgcctagg tctgcagctc     1020

caccacggac cattcgaggg ctccgaactg aagaaaacca agatcgacga tgctccctct     1080

gagctaccgg gccgccctcg tcagctgtct cctctcgtgg ctgagcatcc gccggcctgg     1140

cctgcgcagc cgcctcaccc cttcttcgtc ttcacaaacc atgagatgag tgcatcagga     1200

gatctccaca ggaggcctgc aggggctgtt cccagctggg catggcaggt ggcagcagca     1260

gctcctcctc ctgccgccct gccgtcgtcc gctgcagcat catcaggatt ctccaacacc     1320

gccacgacag ctgccaccac cgccccatcg gcctcctccc tccggtactg cccgccgccg     1380

ccgccgccgt cgagccatca ccatccccgc tga                                  1413


<210>  522
<211>  514
<212>  PRT
<213>  Zea Mays

<400>  522

Met Thr Thr Ser Thr Thr Ala Lys Gln Leu Arg Arg Val Arg Thr Leu 
1               5                   10                  15      


Gly Arg Gly Ala Ser Gly Ala Val Val Trp Leu Ala Ser Asp Glu Ala 
            20                  25                  30          


Ser Gly Glu Leu Val Ala Val Lys Ser Ala Arg Ala Ala Gly Ala Ala 
        35                  40                  45              


Ala Gln Leu Gln Arg Glu Gly Arg Val Leu Arg Gly Leu Ser Ser Pro 
    50                  55                  60                  


His Ile Val Pro Cys Leu Gly Ser Arg Ala Ala Ala Gly Gly Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Leu Glu Phe Ala Pro Gly Gly Ser Leu Ala Asp Glu Ala 
                85                  90                  95      


Ala Arg Ser Gly Gly Gly Arg Leu Ala Glu Arg Ala Ile Gly Ala Tyr 
            100                 105                 110         


Ala Gly Asp Val Ala Arg Gly Leu Ala Tyr Leu His Gly Arg Ser Leu 
        115                 120                 125             


Val His Gly Asp Val Lys Ala Arg Asn Val Val Ile Gly Gly Asp Gly 
    130                 135                 140                 


Arg Ala Arg Leu Thr Asp Phe Gly Cys Ala Arg Pro Ala Gly Gly Ser 
145                 150                 155                 160 


Thr Arg Pro Val Gly Gly Thr Pro Ala Phe Met Ala Pro Glu Val Ala 
                165                 170                 175     


Arg Gly Gln Glu Gln Gly Pro Ala Ala Asp Val Trp Ala Leu Gly Cys 
            180                 185                 190         


Met Val Val Glu Leu Ala Thr Gly Arg Ala Pro Trp Ser Asp Val Glu 
        195                 200                 205             


Gly Asp Asp Leu Leu Ala Ala Leu His Arg Ile Gly Tyr Thr Asp Asp 
    210                 215                 220                 


Val Pro Glu Val Pro Ala Trp Leu Ser Pro Glu Ala Lys Asp Phe Leu 
225                 230                 235                 240 


Ala Gly Cys Phe Glu Arg Arg Ala Ala Ala Arg Pro Thr Ala Ala Gln 
                245                 250                 255     


Pro Ala Ala His Pro Phe Val Val Ala Ser Ala Ser Ala Ala Ala Ala 
            260                 265                 270         


Ile Arg Gly Pro Ala Lys Gln Glu Val Val Pro Ser Pro Lys Ser Thr 
        275                 280                 285             


Leu His Asp Ala Phe Trp Asp Ser Asp Ala Glu Asp Glu Ala Asp Glu 
    290                 295                 300                 


Met Ser Thr Gly Ala Ala Ala Glu Arg Ile Gly Ala Leu Ala Cys Ala 
305                 310                 315                 320 


Ala Ser Ala Leu Pro Asp Trp Asp Thr Glu Glu Gly Trp Ile Asp Leu 
                325                 330                 335     


Gln Asp Asp His Ser Ala Gly Thr Ala Asp Ala Pro Pro Ala Pro Val 
            340                 345                 350         


Ala Asp Tyr Phe Ile Ser Trp Ala Glu Pro Ser Asp Ala Glu Leu Glu 
        355                 360                 365             


Pro Phe Val Ala Val Ala Ala Ala Ala Gly Leu Pro His Val Ala Gly 
    370                 375                 380                 


Val Ala Leu Ala Gly Ala Thr Ala Val Asn Leu Gln Gly Ser Tyr Tyr 
385                 390                 395                 400 


Tyr Tyr Pro Pro Met His Leu Gly Val Arg Gly Asn Glu Ile Pro Arg 
                405                 410                 415     


Pro Leu Leu Asp His His Gly Asp Gly Leu Glu Lys Gly Gln Gly Ser 
            420                 425                 430         


His Arg Val Cys Asn Arg Glu Thr Glu Lys Val Thr Met Lys Arg Ile 
        435                 440                 445             


Ser Leu Lys Arg Arg Ala Ala Phe Leu Leu Asp Gln His His Val Arg 
    450                 455                 460                 


Ser Leu Asp Lys Leu Glu Tyr Arg Pro Arg His Asp Arg Met Leu Arg 
465                 470                 475                 480 


Arg Arg Gln Ser Ile Tyr Arg Ser Asn Ser Val Leu Gly Tyr Asp Val 
                485                 490                 495     


Ser Lys Gly Arg Gln Val Arg Trp Arg Arg Ala Val Cys Ile Ala Val 
            500                 505                 510         


Ala Ala 
        


<210>  523
<211>  1545
<212>  DNA
<213>  Zea mays

<400>  523
atgacgacgt cgaccacggc gaagcagctc cggcgcgtgc gcacgctcgg ccgcggcgcg       60

tcgggcgccg tggtgtggct ggcctccgac gaggcctcgg gcgagctggt ggcggtcaag      120

tcggcgcgcg ccgccggggc cgcggcgcag ctgcagcgcg agggccgcgt cctccggggc      180

ctctcgtcgc cgcacatcgt gccctgcctc ggctcccgcg ccgcggcggg cggcgagtac      240

cagctcctgc tggagttcgc gccgggcggg tcgctggccg acgaggccgc caggagcggc      300

gggggccgcc tcgcggagcg cgccatcggc gcctacgccg gggacgtggc gcgcgggctg      360

gcgtacctcc acggccggtc gctcgtgcac ggggacgtca aggcccggaa cgtggtcatc      420

ggcggcgacg ggcgcgccag gctgaccgac ttcgggtgcg cgaggccggc cggcgggtcg      480

acgcgccccg tcgggggcac cccggcgttc atggcgcccg aggtggcgcg cggccaggag      540

cagggccccg ccgccgacgt ctgggcgctc gggtgcatgg tcgtcgagct ggccacgggc      600

cgcgcgccct ggagcgacgt ggagggcgac gacctcctcg ccgcgctcca ccggatcggg      660

tacacggacg acgtgccgga ggtgcccgcg tggctgtcgc ccgaggccaa ggacttcctg      720

gccggctgct tcgagcgccg cgccgccgcc cggcccacgg ccgcgcagcc cgcggcgcac      780

ccgttcgtcg tcgcctccgc ctccgccgcc gccgccatcc gcggcccggc gaagcaggag      840

gtggtcccgt cacccaagag cacgctgcac gacgcgttct gggactcgga cgccgaggac      900

gaagcggacg agatgtcgac gggcgcggcg gccgagagga tcggggcatt ggcgtgcgcc      960

gcctccgcgc tgcctgactg ggacaccgag gaaggctgga tcgacctcca ggacgaccac     1020

tcggccggaa ctgccgacgc accgccggcg cccgtcgcgg actacttcat cagctgggcg     1080

gagccgtcag acgcagagct ggaaccattc gtcgccgtcg ccgccgccgc aggtctcccg     1140

cacgttgcag gagttgcatt agcaggcgcc accgccgtta acctgcaggg cagttattat     1200

tattacccgc ctatgcatct aggcgtccgc ggaaacgaga ttccacgccc gttgttggat     1260

catcatggcg acgggttaga aaaggggcag ggatcccacc gcgtttgtaa cagagaaaca     1320

gaaaaggtaa caatgaaacg aatttcgtta aaaagaagag ctgctttcct tctcgaccag     1380

catcacgtgc gatcgctgga caaactggaa tatcgtccac gtcacgaccg aatgctgcgt     1440

cgacggcaat ctatatatcg gagcaatagc gtccttggtt acgacgttag caaaggtagg     1500

caggtccgtt ggcgccgtgc ggtttgcatt gccgttgctg cctga                     1545


<210>  524
<211>  671
<212>  DNA
<213>  zea mays

<400>  524
cggatccact agtaacggcc gccagtgtgc tggaattcgc ccttgacggc ccgggctggt       60

atttcaaaac tatagtattt taaaattgca ttaacaaaca tgtcctaatt ggtactcctg      120

agatactata ccctcctgtt ttaaaatagt tggcattatc gaattatcat tttacttttt      180

aatgttttct cttcttttaa tatattttat gaattttaat gtattttaaa atgttatgca      240

gttcgctctg gacttttctg ctgcgcctac acttgggtgt actgggccta aattcagcct      300

gaccgaccgc ctgcattgaa taatggatga gcaccggtaa aatccgcgta cccaactttc      360

gagaagaacc gagacgtggc gggccgggcc accgacgcac ggcaccagcg actgcacacg      420

tcccgccggc gtacgtgtac gtgctgttcc ctcactggcc gcccaatcca ctcatgcatg      480

cccacgtaca cccctgccgt ggcgcgccca gatcctaatc ctttcgccgt tctgcacttc      540

tgctgcctat aaatggcggc atcgaccgtc acctgcttca ccaccggcga gccacatcga      600

gaacacgatc gagcacacaa gcacgaagac tcgtttagga gaaaccacaa accaccaagc      660

cgtgcaagca c                                                           671


<210>  525
<211>  245
<212>  PRT
<213>  zea mays

<400>  525

Met Gly Arg Gly Lys Val Gln Leu Lys Arg Ile Glu Asn Lys Ile Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Ser Lys Arg Arg Ser Gly Leu Leu Lys Lys Ala 
            20                  25                  30          


His Glu Ile Ser Val Leu Cys Asp Ala Glu Val Ala Leu Ile Ile Phe 
        35                  40                  45              


Ser Thr Lys Gly Lys Leu Tyr Glu Tyr Ser Thr Asp Ser Cys Met Asp 
    50                  55                  60                  


Lys Ile Leu Glu Arg Tyr Glu Arg Tyr Ser Tyr Ala Glu Lys Val Leu 
65                  70                  75                  80  


Ile Ser Ala Glu Tyr Glu Thr Gln Gly Asn Trp Cys His Glu Tyr Arg 
                85                  90                  95      


Lys Leu Lys Ala Lys Val Glu Thr Ile Gln Lys Cys Gln Lys His Leu 
            100                 105                 110         


Met Gly Glu Asp Leu Glu Thr Leu Asn Leu Lys Glu Leu Gln Gln Leu 
        115                 120                 125             


Glu Gln Gln Leu Glu Ser Ser Leu Lys His Ile Arg Thr Arg Lys Ser 
    130                 135                 140                 


Gln Leu Met Val Glu Ser Ile Ser Ala Leu Gln Arg Lys Glu Lys Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Asn Lys Val Leu Gln Lys Glu Leu Ala Glu Lys Gln 
                165                 170                 175     


Lys Asp Gln Arg Gln Gln Val Gln Arg Asp Gln Thr Gln Gln Gln Thr 
            180                 185                 190         


Ser Ser Ser Ser Thr Ser Phe Met Leu Arg Glu Ala Ala Pro Thr Thr 
        195                 200                 205             


Asn Val Ser Ile Phe Pro Val Ala Ala Gly Gly Arg Val Val Glu Gly 
    210                 215                 220                 


Ala Ala Ala Gln Pro Gln Ala Arg Val Gly Leu Pro Pro Trp Met Leu 
225                 230                 235                 240 


Ser His Leu Ser Cys 
                245 


<210>  526
<211>  738
<212>  DNA
<213>  zea mays

<400>  526
atggggcgcg ggaaggtgca gctgaagcgg atcgagaaca agatcaaccg ccaggtgaca       60

ttctccaagc gccgctcggg gctactcaag aaggcgcacg agatctccgt gctctgcgac      120

gccgaggtcg cgctcatcat cttctccacc aagggcaagc tctacgagta ctctaccgat      180

tcatgtatgg acaaaattct tgaacggtat gagcgctact cctatgcaga aaaggttctc      240

atttccgcag aatatgaaac tcagggcaat tggtgccatg aatatagaaa actaaaggcg      300

aaggtcgaga caatacagaa atgtcaaaag cacctcatgg gagaggatct tgaaactttg      360

aatctcaaag agcttcagca actagagcag cagctggaga gttcactgaa acatatcaga      420

acaaggaaga gccagcttat ggtcgagtca atttcagcgc tccaacggaa ggagaagtca      480

ctgcaggagg agaacaaggt tctgcagaag gagctcgcgg agaagcagaa agaccagcgg      540

cagcaagtgc aacgggacca aactcaacag cagaccagtt cgtcttccac gtccttcatg      600

ttaagggaag ctgccccaac aacaaatgtc agcatcttcc ctgtggcagc aggcgggagg      660

gtggtggaag gggcagcagc gcagccgcag gctcgcgttg gactgccacc atggatgctt      720

agccatctga gctgctga                                                    738


<210>  527
<211>  80
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(80)
<223>  sequence of Figure 34B

<400>  527
gctaaagagg aagtgcagct cttcttgggg aatgctggaa ctgcaatgcg gccattgaca       60

gcagctgtta ctgctgctgg                                                   80


<210>  528
<211>  80
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(80)
<223>  sequence of Figure 34c

<400>  528
gctagagagg aagtgcagct cttcttgggg aatgctggaa tcgcaatgcg gtcattgaca       60

gcagctgtta ctgctgctgg                                                   80


<210>  529
<211>  37
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  sequence of Figure 35b

<400>  529
catctcacga tcagatgcac cgcatgtcgc atgccta                                37


<210>  530
<211>  42
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  sequence of Figure 35c

<400>  530
catatctgca cgatcagata tgcaccgcat gtcgcatatc tg                          42


<210>  531
<211>  31
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  sequence of Figure 37

<400>  531
gtttttgaac ttcagttacg tgcttgatgg a                                      31


<210>  532
<211>  31
<212>  DNA
<213>  zea mays


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  sequence of Figure 37

<400>  532
gtttttgaac ttcaggtacg tgcttgatgg a                                      31


<210>  533
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Southern genomic probe

<400>  533
agctttatcc atccatccat cgcgctagct ggctgcaggc acgggttatc ttatcttgtc       60

gtccagagga cgacacacgg ccggccggtg aagtaaaagg gagtaatctt attttgccag      120

gacgaggggc ggtacatgat attacacacg taccatgcat gcatatatgc atggacaagg      180

tacgtcgtcg tcgatcgacg tcgatgcata tgtgtgtatg tatgtacgtg cataatgcat      240

ggtaccagct gctggcttat atatatttgt caccgatcga tgcatgctgc tgctctacac      300

ggtttgacac tttaatttga ctcatcgatg accttgctag atagtagcgg ctcgtcaatt      360

aatgagccat caagttaaca agagggcacg ggcttgcgcg actgattcca ccttattaac      420

atacgccctg cgcccgcgcg tgctgtacgt acgagaatt                             459


<210>  534
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Southern MoPAT probe

<400>  534
tcgaagtcgc gctgccagaa gccgacgtcg tgccagccgc cgtgcttgta gccggcggcg       60

cggagggtgc cgcgggcggt gtagccgagg gcctcgtgga ggcgcacgga cgggtcgttc      120

gggaggccga tcacggccac cacggacttg aagccctggg cctccatgct cttgaggagg      180

tgggtgtaga gggtggagcc gaggccgagg cgctggtggc ggtgggacac gtacacggtg      240

gactccacgg tccagtcgta ggcgttgcgg gccttccacg ggccggcgta ggcgatgccg      300

gccaccacgc cctccacctc ggccacgagc cacgggtagc ggtcctggag gcgctccagg      360

tcgtcgatcc actcctgcgg ggtctgcggc tcggtgcgga agttcacggt ggaggtctcg      420

atgtagtggt tcacgatgtc gcacac                                           446


<210>  535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RF-FPCas-1

<400>  535
gcaggtctca cgacggttgg                                                   20


<210>  536
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RF-FPCas-2

<400>  536
gtaaagtacg cgtacgtgtg agg                                               23


<210>  537
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALSCas-4

<400>  537
gctgctcgat tccgtcccca tgg                                               23


<210>  538
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS modification repair template 804

<400>  538
agcttacagc cgccgcaacc atggccaccg ccgccgccgc gtctaccgcg ctcactggcg       60

ccactaccgc tgcgcccaag gcgaggcgcc gggcgcacct cctggccacc cgccgcgccc      120

tcgccgcgcc catcaggtgc tcagcggcgt cacccgccat gccgatggct cccccggcca      180

ccccgctccg gccgtggggc cccaccgatc cccgcaaggg cgccgacatc ctcgtcgagt      240

ccctcgagcg ctgcggcgtc cgcgacgtct tcgcctaccc cggcggcgcg tccatggaga      300

tccaccaggc actcacccgc tcccccgtca tcgccaacca cctcttccgc cacgagcaag      360

gggaggcctt tgcggcctcc ggctacgcgc gctcctcggg ccgcgtcggc gtctgcatcg      420

ccacctccgg ccccggcgcc accaaccttg tctccgcgct cgccgacgcg ttgctcgact      480

ccgtccccat tgtcgccatc acgggacagg tgtcgcgacg catgattggc accgacgcct      540

tccaggagac gcccatcgtc gaggtcaccc gctccatcac caagcacaac tacctggtcc      600

tcgacgtcga cgacatcccc cgcgtcgtgc aggaggcttt cttcctcgcc tcctctggtc      660

gaccagggcc ggtgcttgtc gacatcccca aggacatcca gcagcagatg gcggtgcctg      720

tctgggacaa gcccatgagt ctgcctgggt acattgcgcg ccttcccaag ccccctgcga      780

ctgagttgct tgagcagaag ggcg                                             804


<210>  539
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS modification repair template 127

<400>  539
aaccttgtct ccgcgctcgc cgacgcgttg ctcgactccg tccccattgt cgccatcacg       60

ggacaggtgt cgcgacgcat gattggcacc gacgccttcc aggagacgcc catcgtcgag      120

gtcaccc                                                                127


<210>  540
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS Forward_primer;

<400>  540
ctacgcacat ccccctttct cccac                                             25


<210>  541
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS Reverse_primer

<400>  541
atgcatacct agcatgcgca gagacagtgg gtcgtc                                 36


<210>  542
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  soy ALS1-CR1, Cas9 target sequence

<400>  542
caccggccag gtcccccgcc gg                                                22


<210>  543
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  soy ALS2-CR2, Cas9 target sequence

<400>  543
ggcgtcggtg ccgatcatcc gg                                                22


<210>  544
<211>  9093
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC880

<400>  544
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg caccggccag gtcccccgcg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggacaa aaagtactca atagggctcg acatagggac     2100

taactccgtt ggatgggccg tcatcaccga cgagtacaag gtgccctcca agaagttcaa     2160

ggtgttggga aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt     2220

cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac     2280

cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga tggccaaggt     2340

ggacgactcc ttcttccacc gccttgagga atcattcctg gtggaggagg ataaaaagca     2400

cgagagacac ccaatcttcg ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc     2460

taccatctac cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt     2520

gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga     2580

cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc agacctacaa     2640

ccagcttttc gaggagaacc caatcaacgc cagtggagtt gacgccaagg ctatcctctc     2700

tgctcgtctg tcaaagtcca ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa     2760

gaagaacgga ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa     2820

gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga     2880

tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct tcctcgccgc     2940

taagaacttg tccgacgcaa tcctgctgtc cgacatcctg agagtcaaca ctgagattac     3000

caaagctcct ctgtctgctt ccatgattaa gcgctacgac gagcaccacc aagatctgac     3060

cctgctcaag gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga     3120

ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta     3180

caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt tggtgaagtt     3240

gaacagagag gacctgttga ggaagcagag aaccttcgac aacggaagca tccctcacca     3300

aatccacctg ggagagctcc acgccatctt gaggaggcag gaggatttct atcccttcct     3360

gaaggacaac cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg     3420

gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat     3480

tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt ctttcatcga     3540

gaggatgacc aacttcgata aaaatctgcc caacgagaag gtgctgccca agcactccct     3600

gttgtacgag tatttcacag tgtacaacga gctcaccaag gtgaagtacg tcacagaggg     3660

aatgaggaag cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt     3720

caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga     3780

gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct cccttgggac     3840

ttaccacgat ctgctcaaga ttattaaaga caaggacttc ctggacaacg aggagaacga     3900

ggacatcctt gaggacatcg tgctcaccct gaccttgttc gaagacaggg aaatgatcga     3960

agagaggctc aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag     4020

acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa     4080

gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca acaggaactt     4140

catgcagctc attcacgacg actccttgac cttcaaggag gacatccaga aggctcaggt     4200

gtctggacag ggtgactcct tgcatgagca cattgctaac ttggccggct ctcccgctat     4260

taagaagggc attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg     4320

ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg     4380

gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag agcttggctc     4440

tcagatcctc aaggagcacc ccgtcgagaa cactcagctg cagaacgaga agctgtacct     4500

gtactacctc caaaacggaa gggacatgta cgtggaccag gagctggaca tcaacaggtt     4560

gtccgactac gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga     4620

caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga     4680

ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca agctcatcac     4740

ccagcgtaag ttcgacaacc tgactaaggc tgagagagga ggattgtccg agctcgataa     4800

ggccggattc atcaagagac agctcgtcga aacccgccaa attaccaagc acgtggccca     4860

aattctggat tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt     4920

caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta     4980

caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca acgctgtcgt     5040

tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct gagttcgtct acggcgacta     5100

caaggtgtac gacgtgagga agatgatcgc taagtctgag caggagatcg gcaaggccac     5160

cgccaagtac ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc     5220

caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt     5280

gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa     5340

catcgtcaag aagaccgaag ttcagaccgg aggattctcc aaggagtcca tcctccccaa     5400

gagaaactcc gacaagctga tcgctagaaa gaaagactgg gaccctaaga agtacggagg     5460

cttcgattct cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa     5520

gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc     5580

cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg tgaagaagga     5640

cctcatcatc aagctgccca agtactccct cttcgagttg gagaacggaa ggaagaggat     5700

gctggcttct gccggagagt tgcagaaggg aaatgagctc gcccttccct ccaagtacgt     5760

gaacttcctg tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga     5820

gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat     5880

ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg tgctgtccgc     5940

ctacaacaag cacagggata agcccattcg cgagcaggct gaaaacatta tccacctgtt     6000

taccctcaca aacttgggag cccctgctgc cttcaagtac ttcgacacca ccattgacag     6060

gaagagatac acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac     6120

cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc     6180

caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga ttggccaact     6240

taattaatgt atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg     6300

gcatcaaagt tgtgtgttat gtgtaattac tagttatctg aataaaagag aaagagatca     6360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat     6420

gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat taatatcaat     6480

tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc aagcttatcg     6540

ataccgtcga gggggggccc ggtaccggcg cgccgttcta tagtgtcacc taaatcgtat     6600

gtgtatgata cataaggtta tgtattaatt gtagccgcgt tctaacgaca atatgtccat     6660

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     6720

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6780

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6840

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgaccaaaat     6900

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6960

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     7020

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     7080

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     7140

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     7200

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     7260

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     7320

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     7380

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     7440

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     7500

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     7560

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     7620

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     7680

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     7740

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcaggt tgatcagatc     7800

tcgatcccgc gaaattaata cgactcacta tagggagacc acaacggttt ccctctagaa     7860

ataattttgt ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga     7920

cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct     7980

cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga tatgtcctgc     8040

gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg cactttgcat     8100

cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag agcctgacct     8160

attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc     8220

ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc     8280

agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact acatggcgtg     8340

atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg atggacgaca     8400

ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc gaggactgcc     8460

ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg     8520

gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg     8580

tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag acgcgctact     8640

tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat atgctccgca     8700

ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat gcagcttggg     8760

cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa     8820

tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg     8880

gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca gcttggatcg     8940

atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat     9000

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag     9060

gaactatatc cggatgatcg ggcgcgccgg tac                                  9093


<210>  545
<211>  9093
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QC881

<400>  545
ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta       60

cctagtaata agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc      120

tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt      180

catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa      240

atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac      300

taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt catgtggtct      360

cgttccccat ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag      420

atgcacaaca acaaagcttg ggcgtcggtg ccgatcatcg ttttagagct agaaatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

tttgcggccg caattggatc gggtttactt attttgtggg tatctatact tttattagat      600

ttttaatcag gctcctgatt tctttttatt tcgattgaat tcctgaactt gtattattca      660

gtagatcgaa taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca      720

tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt      780

tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt attactttta      840

aaaaaatcat aaaggtttag tattttttta aaataaatat aggaatagtt ttactattca      900

ctgctttaat agaaaaatag tttaaaattt aagatagttt taatcccagc atttgccacg      960

tttgaacgtg agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt     1020

cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg     1080

aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct caatcccacg     1140

cgagtagagc acagtaacct tcaaataagc gaatggggca taatcagaaa tccgaaataa     1200

acctaggggc attatcggaa atgaaaagta gctcactcaa tataaaaatc taggaaccct     1260

agttttcgtt atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg     1320

aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc     1380

tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg ttatgttttt     1440

ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt cgctttgttt ttgtggttca     1500

gttttttagg attcttttgg tttttgaatc gattaatcgg aagagatttt cgagttattt     1560

ggtgtgttgg aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa     1620

catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc     1680

tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag gtttgtttta     1740

acaggattaa aagtttttta agcatgttga aggagtcttg tagatatgta accgtcgata     1800

gtttttttgt gggtttgttc acatgttatc aagcttaatc ttttactatg tatgcgacca     1860

tatctggatc cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt     1920

gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta     1980

tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta tttctttgaa     2040

ttgattctag tttaagtaat ccatggacaa aaagtactca atagggctcg acatagggac     2100

taactccgtt ggatgggccg tcatcaccga cgagtacaag gtgccctcca agaagttcaa     2160

ggtgttggga aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt     2220

cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac     2280

cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga tggccaaggt     2340

ggacgactcc ttcttccacc gccttgagga atcattcctg gtggaggagg ataaaaagca     2400

cgagagacac ccaatcttcg ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc     2460

taccatctac cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt     2520

gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga     2580

cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc agacctacaa     2640

ccagcttttc gaggagaacc caatcaacgc cagtggagtt gacgccaagg ctatcctctc     2700

tgctcgtctg tcaaagtcca ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa     2760

gaagaacgga ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa     2820

gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga     2880

tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct tcctcgccgc     2940

taagaacttg tccgacgcaa tcctgctgtc cgacatcctg agagtcaaca ctgagattac     3000

caaagctcct ctgtctgctt ccatgattaa gcgctacgac gagcaccacc aagatctgac     3060

cctgctcaag gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga     3120

ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta     3180

caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt tggtgaagtt     3240

gaacagagag gacctgttga ggaagcagag aaccttcgac aacggaagca tccctcacca     3300

aatccacctg ggagagctcc acgccatctt gaggaggcag gaggatttct atcccttcct     3360

gaaggacaac cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg     3420

gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat     3480

tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt ctttcatcga     3540

gaggatgacc aacttcgata aaaatctgcc caacgagaag gtgctgccca agcactccct     3600

gttgtacgag tatttcacag tgtacaacga gctcaccaag gtgaagtacg tcacagaggg     3660

aatgaggaag cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt     3720

caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga     3780

gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct cccttgggac     3840

ttaccacgat ctgctcaaga ttattaaaga caaggacttc ctggacaacg aggagaacga     3900

ggacatcctt gaggacatcg tgctcaccct gaccttgttc gaagacaggg aaatgatcga     3960

agagaggctc aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag     4020

acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa     4080

gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca acaggaactt     4140

catgcagctc attcacgacg actccttgac cttcaaggag gacatccaga aggctcaggt     4200

gtctggacag ggtgactcct tgcatgagca cattgctaac ttggccggct ctcccgctat     4260

taagaagggc attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg     4320

ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg     4380

gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag agcttggctc     4440

tcagatcctc aaggagcacc ccgtcgagaa cactcagctg cagaacgaga agctgtacct     4500

gtactacctc caaaacggaa gggacatgta cgtggaccag gagctggaca tcaacaggtt     4560

gtccgactac gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga     4620

caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga     4680

ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca agctcatcac     4740

ccagcgtaag ttcgacaacc tgactaaggc tgagagagga ggattgtccg agctcgataa     4800

ggccggattc atcaagagac agctcgtcga aacccgccaa attaccaagc acgtggccca     4860

aattctggat tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt     4920

caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta     4980

caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca acgctgtcgt     5040

tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct gagttcgtct acggcgacta     5100

caaggtgtac gacgtgagga agatgatcgc taagtctgag caggagatcg gcaaggccac     5160

cgccaagtac ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc     5220

caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt     5280

gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa     5340

catcgtcaag aagaccgaag ttcagaccgg aggattctcc aaggagtcca tcctccccaa     5400

gagaaactcc gacaagctga tcgctagaaa gaaagactgg gaccctaaga agtacggagg     5460

cttcgattct cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa     5520

gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc     5580

cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg tgaagaagga     5640

cctcatcatc aagctgccca agtactccct cttcgagttg gagaacggaa ggaagaggat     5700

gctggcttct gccggagagt tgcagaaggg aaatgagctc gcccttccct ccaagtacgt     5760

gaacttcctg tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga     5820

gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat     5880

ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg tgctgtccgc     5940

ctacaacaag cacagggata agcccattcg cgagcaggct gaaaacatta tccacctgtt     6000

taccctcaca aacttgggag cccctgctgc cttcaagtac ttcgacacca ccattgacag     6060

gaagagatac acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac     6120

cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc     6180

caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga ttggccaact     6240

taattaatgt atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg     6300

gcatcaaagt tgtgtgttat gtgtaattac tagttatctg aataaaagag aaagagatca     6360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat     6420

gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat taatatcaat     6480

tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc aagcttatcg     6540

ataccgtcga gggggggccc ggtaccggcg cgccgttcta tagtgtcacc taaatcgtat     6600

gtgtatgata cataaggtta tgtattaatt gtagccgcgt tctaacgaca atatgtccat     6660

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     6720

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6780

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6840

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgaccaaaat     6900

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6960

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     7020

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     7080

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     7140

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     7200

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     7260

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     7320

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     7380

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     7440

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     7500

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     7560

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     7620

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     7680

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     7740

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcaggt tgatcagatc     7800

tcgatcccgc gaaattaata cgactcacta tagggagacc acaacggttt ccctctagaa     7860

ataattttgt ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga     7920

cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct     7980

cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga tatgtcctgc     8040

gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg cactttgcat     8100

cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag agcctgacct     8160

attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc     8220

ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc     8280

agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact acatggcgtg     8340

atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg atggacgaca     8400

ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc gaggactgcc     8460

ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg     8520

gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg     8580

tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag acgcgctact     8640

tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat atgctccgca     8700

ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat gcagcttggg     8760

cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa     8820

tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg     8880

gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca gcttggatcg     8940

atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat     9000

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag     9060

gaactatatc cggatgatcg ggcgcgccgg tac                                  9093


<210>  546
<211>  1113
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RTW1026A

<400>  546
agcttggtac cgagctcgga tccactagta tggcggccac cgcttccaga accacccgat       60

tctcttcttc ctcttcacac cccaccttcc ccaaacgcat tactagatcc accctccctc      120

tctctcatca aaccctcacc aaacccaacc acgctctcaa aatcaaatgt tccatctcca      180

aaccccccac ggcggcgccc ttcaccaagg aagcgccgac cacggagccc ttcgtgtcac      240

ggttcgcctc cggcgaacct cgcaagggcg cggacatcct tgtggaggcg ctggagaggc      300

agggcgtgac gacggtgttc gcgtaccccg gcggtgcgtc gatggagatc caccaggcgc      360

tcacgcgctc cgccgccatc cgcaacgtgc tcccgcgcca cgagcagggc ggcgtcttcg      420

ccgccgaagg ctacgcgcgt tcctccggcc tccccggcgt ctgcattgcc acctccggcc      480

ccggcgccac caacctcgtg agcggcctcg ccgacgcttt aatggacagc gtcccagtcg      540

tcgccatcac cggccaggtc agccgtcgca tgatcggtac cgacgccttc caagaaaccc      600

cgatcgtgga ggtgagcaga tccatcacga agcacaacta cctcatcctc gacgtcgacg      660

acatcccccg cgtcgtcgcc gaggctttct tcgtcgccac ctccggccgc cccggtccgg      720

tcctcatcga cattcccaaa gacgttcagc agcaactcgc cgtgcctaat tgggacgagc      780

ccgttaacct ccccggttac ctcgccaggc tgcccaggcc ccccgccgag gcccaattgg      840

aacacattgt cagactcatc atggaggccc aaaagcccgt tctctacgtc ggcggtggca      900

gtttgaattc cagtgctgaa ttgaggcgct ttgttgaact cactggtatt cccgttgcta      960

gcactttaat gggtcttgga acttttccta ttggtgatga atattccctt cagatgctgg     1020

gtatgcatgg tactgtttat gctaactatg ctgttgacaa tagtgatttg ttgcttgcct     1080

ttggggtaag gtttgatgac cgtgttactg gga                                  1113


<210>  547
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  WOL900, Forward_primer

<400>  547
atcaccggcc aggtcag                                                      17


<210>  548
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  WOL578, Reverse_primer

<400>  548
acttaccctc cactcctttc tcctc                                             25


<210>  549
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  WOL573, Forward_primer

<400>  549
atggcggcca ccgcttccag aaccacccg                                         29


<210>  550
<211>  638
<212>  PRT
<213>  zea mays

<400>  550

Met Ala Thr Ala Ala Ala Ala Ser Thr Ala Leu Thr Gly Ala Thr Thr 
1               5                   10                  15      


Ala Ala Pro Lys Ala Arg Arg Arg Ala His Leu Leu Ala Thr Arg Arg 
            20                  25                  30          


Ala Leu Ala Ala Pro Ile Arg Cys Ser Ala Ala Ser Pro Ala Met Pro 
        35                  40                  45              


Met Ala Pro Pro Ala Thr Pro Leu Arg Pro Trp Gly Pro Thr Glu Pro 
    50                  55                  60                  


Arg Lys Gly Ala Asp Ile Leu Val Glu Ser Leu Glu Arg Cys Gly Val 
65                  70                  75                  80  


Arg Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu Ile His Gln 
                85                  90                  95      


Ala Leu Thr Arg Ser Pro Val Ile Ala Asn His Leu Phe Arg His Glu 
            100                 105                 110         


Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr Ala Arg Ser Ser Gly Arg 
        115                 120                 125             


Val Gly Val Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val 
    130                 135                 140                 


Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser Val Pro Met Val Ala Ile 
145                 150                 155                 160 


Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr Asp Ala Phe Gln Glu 
                165                 170                 175     


Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His Asn Tyr Leu 
            180                 185                 190         


Val Leu Asp Val Asp Asp Ile Pro Arg Val Val Gln Glu Ala Phe Phe 
        195                 200                 205             


Leu Ala Ser Ser Gly Arg Pro Gly Pro Val Leu Val Asp Ile Pro Lys 
    210                 215                 220                 


Asp Ile Gln Gln Gln Met Ala Val Pro Val Trp Asp Lys Pro Met Ser 
225                 230                 235                 240 


Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys Pro Pro Ala Thr Glu Leu 
                245                 250                 255     


Leu Glu Gln Val Leu Arg Leu Val Gly Glu Ser Arg Arg Pro Val Leu 
            260                 265                 270         


Tyr Val Gly Gly Gly Cys Ala Ala Ser Gly Glu Glu Leu Arg Arg Phe 
        275                 280                 285             


Val Glu Leu Thr Gly Ile Pro Val Thr Thr Thr Leu Met Gly Leu Gly 
    290                 295                 300                 


Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu Arg Met Leu Gly Met His 
305                 310                 315                 320 


Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Lys Ala Asp Leu Leu Leu 
                325                 330                 335     


Ala Leu Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys Ile Glu Ala 
            340                 345                 350         


Phe Ala Ser Arg Ala Lys Ile Val His Val Asp Ile Asp Pro Ala Glu 
        355                 360                 365             


Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile Cys Ala Asp Val Lys 
    370                 375                 380                 


Leu Ala Leu Gln Gly Met Asn Ala Leu Leu Glu Gly Ser Thr Ser Lys 
385                 390                 395                 400 


Lys Ser Phe Asp Phe Gly Ser Trp Asn Asp Glu Leu Asp Gln Gln Lys 
                405                 410                 415     


Arg Glu Phe Pro Leu Gly Tyr Lys Thr Ser Asn Glu Glu Ile Gln Pro 
            420                 425                 430         


Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr Lys Gly Glu Ala Ile 
        435                 440                 445             


Ile Gly Thr Gly Val Gly Gln His Gln Met Trp Ala Ala Gln Tyr Tyr 
    450                 455                 460                 


Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser Ser Ala Gly Leu Gly Ala 
465                 470                 475                 480 


Met Gly Phe Gly Leu Pro Ala Ala Ala Gly Ala Ser Val Ala Asn Pro 
                485                 490                 495     


Gly Val Thr Val Val Asp Ile Asp Gly Asp Gly Ser Phe Leu Met Asn 
            500                 505                 510         


Val Gln Glu Leu Ala Met Ile Arg Ile Glu Asn Leu Pro Val Lys Val 
        515                 520                 525             


Phe Val Leu Asn Asn Gln His Leu Gly Met Val Val Gln Trp Glu Asp 
    530                 535                 540                 


Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr Leu Gly Asn Pro Glu 
545                 550                 555                 560 


Asn Glu Ser Glu Ile Tyr Pro Asp Phe Val Thr Ile Ala Lys Gly Phe 
                565                 570                 575     


Asn Ile Pro Ala Val Arg Val Thr Lys Lys Asn Glu Val Arg Ala Ala 
            580                 585                 590         


Ile Lys Lys Met Leu Glu Thr Pro Gly Pro Tyr Leu Leu Asp Ile Ile 
        595                 600                 605             


Val Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser Gly Gly Ala 
    610                 615                 620                 


Phe Lys Asp Met Ile Leu Asp Gly Asp Gly Arg Thr Val Tyr 
625                 630                 635             


