                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER 
 
<120> SELECTIVE GRP94 INHIBITORS AND USES THEREOF

<130> 2003080-0708

<140>
<141>

<150> 61/866,932
<151> 2013-08-16

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 801
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Ala Lys 
            580                 585                 590         


Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg Glu 
        595                 600                 605             


Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp Lys 
    610                 615                 620                 


Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu Thr 
625                 630                 635                 640 


Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly Asn 
                645                 650                 655     


Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile 
            660                 665                 670         


Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro 
        675                 680                 685             


Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu 
    690                 695                 700                 


Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala 
705                 710                 715                 720 


Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp 
                725                 730                 735     


Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Ala Lys 
            740                 745                 750         


Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr 
        755                 760                 765             


Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr 
    770                 775                 780                 


Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys Asp Glu 
785                 790                 795                 800 


Leu 
    


<210> 2
<211> 255
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met 
            20                  25                  30          


Glu Glu Glu Glu Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln 
        35                  40                  45              


Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe 
    50                  55                  60                  


Leu Arg Glu Leu Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg 
65                  70                  75                  80  


Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu 
                85                  90                  95      


His Ile Asn Leu Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val 
            100                 105                 110         


Asp Thr Gly Ile Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly 
        115                 120                 125             


Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala 
    130                 135                 140                 


Gly Ala Asp Ile Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser 
145                 150                 155                 160 


Ala Tyr Leu Val Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp 
                165                 170                 175     


Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val 
            180                 185                 190         


Arg Thr Asp Thr Gly Glu Pro Met Gly Arg Gly Thr Val Ile Leu His 
        195                 200                 205             


Leu Lys Glu Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu 
    210                 215                 220                 


Ile Val Lys Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe 
225                 230                 235                 240 


Val Glu Lys Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu 
                245                 250                 255 


<210> 3
<211> 239
<212> PRT
<213> Homo sapiens

<400> 3
Asp Pro Thr Leu Met Pro Glu Glu Val His His Gly Glu Glu Glu Val 
1               5                   10                  15      


Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile 
            20                  25                  30          


Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile 
        35                  40                  45              


Ser Asn Ala Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr 
    50                  55                  60                  


Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile 
65                  70                  75                  80  


Pro Asn Pro Gln Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly 
                85                  90                  95      


Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser 
            100                 105                 110         


Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser 
        115                 120                 125             


Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala 
    130                 135                 140                 


Glu Lys Val Val Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala 
145                 150                 155                 160 


Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly 
                165                 170                 175     


Glu Pro Ile Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp 
            180                 185                 190         


Gln Thr Glu Tyr Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys 
        195                 200                 205             


His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu 
    210                 215                 220                 


Arg Glu Lys Gly Glu Phe Asn Ser Lys Leu Gly Cys Phe Gly Gly 
225                 230                 235                 


<210> 4
<211> 704
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg 
1               5                   10                  15      


Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro 
            20                  25                  30          


Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn 
        35                  40                  45              


Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala 
    50                  55                  60                  


Glu Asp Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser 
65                  70                  75                  80  


Val Gln Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys 
                85                  90                  95      


Leu Leu Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe 
            100                 105                 110         


Ile Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg 
        115                 120                 125             


His Lys Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His 
    130                 135                 140                 


Leu Gln Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly 
145                 150                 155                 160 


Ile Gly Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala 
                165                 170                 175     


Arg Ser Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu 
            180                 185                 190         


Ala Ser Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala 
        195                 200                 205             


Phe Met Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro 
    210                 215                 220                 


Gly Ser Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu 
225                 230                 235                 240 


Ile Ala Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His 
                245                 250                 255     


Leu Lys Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp 
            260                 265                 270         


Val Val Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn 
        275                 280                 285             


Gly Arg Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys 
    290                 295                 300                 


Asp Val Arg Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln 
305                 310                 315                 320 


Ala His Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro 
                325                 330                 335     


Leu Asn Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met 
            340                 345                 350         


Phe Asp Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg 
        355                 360                 365             


Lys Val Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu 
    370                 375                 380                 


Arg Phe Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu 
385                 390                 395                 400 


Ser Arg Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp 
                405                 410                 415     


Val Leu Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys 
            420                 425                 430         


Asp Ala Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met 
        435                 440                 445             


Arg Glu Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile 
    450                 455                 460                 


Ala Lys Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu 
465                 470                 475                 480 


Thr Ser Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn 
                485                 490                 495     


Ile Tyr Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro 
            500                 505                 510         


Tyr Tyr Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe 
        515                 520                 525             


Glu Gln Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys 
    530                 535                 540                 


Lys Lys Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys 
545                 550                 555                 560 


Glu Glu Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu 
                565                 570                 575     


Lys Glu Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser 
            580                 585                 590         


Arg Val Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala 
        595                 600                 605             


Met Val Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met 
    610                 615                 620                 


Gln Gln Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro 
625                 630                 635                 640 


Thr Leu Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln 
                645                 650                 655     


Leu Arg Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile 
            660                 665                 670         


Tyr Glu Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala 
        675                 680                 685             


Met Val Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His 
    690                 695                 700                 


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ggggtcaacg ttgagggggg                                                   20


