                         SEQUENCE LISTING

<110>  PETERS, Robert T.
       KULMAN, John
 
<120>  Recombinant FVIII Proteins and Uses Thereof

<130>  2159.4180000
<140>  US 61/866,017
<141>  2013-08-14


<160>  211   

<170>  PatentIn version 3.5

<210>  1
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  2
<211>  1438
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1295                 1300                 1305             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1310                 1315                 1320             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1325                 1330                 1335             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1340                 1345                 1350             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1355                 1360                 1365             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1370                 1375                 1380             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1385                 1390                 1395             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1400                 1405                 1410             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1415                 1420                 1425             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1430                 1435             


<210>  3
<211>  4314
<212>  DNA
<213>  Homo sapiens

<400>  3
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg cacagattac tgcttcatcc     3900

tactttacca atatgtttgc cacctggtct ccttcaaaag ctcgacttca cctccaaggg     3960

aggagtaatg cctggagacc tcaggtgaat aatccaaaag agtggctgca agtggacttc     4020

cagaagacaa tgaaagtcac aggagtaact actcagggag taaaatctct gcttaccagc     4080

atgtatgtga aggagttcct catctccagc agtcaagatg gccatcagtg gactctcttt     4140

tttcagaatg gcaaagtaaa ggtttttcag ggaaatcaag actccttcac acctgtggtg     4200

aactctctag acccaccgtt actgactcgc taccttcgaa ttcaccccca gagttgggtg     4260

caccagattg ccctgaggat ggaggttctg ggctgcgagg cacaggacct ctac           4314


<210>  4
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys 
                325                 


<210>  5
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg 
1               5                   10                  15      


Val Pro Lys Ser Phe Pro Phe Asn Thr 
            20                  25  


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro 
1               5                   10          


<210>  7
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr 
1               5                   10                  15      


Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr 
            20                  25                  30          


Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg 
        35                  40                  45              


Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln 
    50                  55                  60                  


His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp 
65                  70                  75                  80  


Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile 
                85                  90                  95      


Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu 
            100                 105                 110         


Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu 
        115                 120                 125             


Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys 
    130                 135                 140                 


Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met 
145                 150                 155                 160 


Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr 
                165                 170                 175     


Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg 
            180                 185                 190         


Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu 
        195                 200                 205             


Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu 
    210                 215                 220                 


Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly 
225                 230                 235                 240 


Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala 
                245                 250                 255     


Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val 
            260                 265                 270         


Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr 
        275                 280                 285             


Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu 
    290                 295                 300                 


Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn 
305                 310                 315                 320 


Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
                325                 330         


<210>  8
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
1               5                   10                  15      


Asn Asn Gly Pro Gln Arg Ile 
            20              


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu 
1               5                   10              


<210>  10
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 
1               5                   10                  15      


Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly 
            20                  25                  30          


Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly 
        35                  40                  45              


Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly 
    50                  55                  60                  


Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 
65                  70                  75                  80  


Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu 
                85                  90                  95      


Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn 
            100                 105                 110         


Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His 
        115                 120                 125             


His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr 
    130                 135                 140                 


Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly 
145                 150                 155                 160 


Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg 
                165                 170                 175     


Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu 
            180                 185                 190         


Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala 
        195                 200                 205             


Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg 
    210                 215                 220                 


Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val 
225                 230                 235                 240 


Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 
                245                 250                 255     


Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val 
            260                 265                 270         


Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly 
        275                 280                 285             


Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg 
    290                 295                 300                 


Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu 
305                 310                 315                 320 


Phe Leu Val Tyr Ser Asn Lys Cys 
                325             


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
1               5                   10                  15      


<210>  12
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1               5                   10              


<210>  13
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4 synthetic polypeptide

<400>  13

Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
1               5                   10                  15      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
            20                  25                  30          


Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 
        35                  40          


<210>  14
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4 synthetic polynucleotide

<400>  14
ggcgcgccag gttctcctgc tggctccccc acctcaacag aagaggggac aagcgaaagc       60

gctacgcctg agagtggccc tggctctgag ccagccacct ccggctctga aacccctgcc      120

tcgagc                                                                 126


<210>  15
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A synthetic polypeptide

<400>  15

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
    130                 135                 140                 


<210>  16
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A, synthetic polynucleotide

<400>  16
ggcgcgccaa ccagtacgga gccgtccgag gggagcgcac caggaagccc ggctgggagc       60

ccgacttcta ccgaagaggg tacatctacc gaaccaagtg aaggttcagc accaggcacc      120

tcaacagaac cctctgaggg ctcggcgcct ggtacaagtg agtccgccac cccagaatcc      180

gggcctggga caagcacaga accttcggaa gggagtgccc ctggaacatc cgaatcggca      240

accccagaat cagggccagg atctgagccc gcgacttcgg gctccgagac gcctgggaca      300

tccaccgagc cctccgaagg atcagcccca ggcaccagca cggagccctc tgagggaagc      360

gcacctggta ccagcgaaag cgcaactccc gaatcaggtc ccggtacgag cgagtcggcg      420

accccggaga gcgggccagg tgcctcgagc                                       450


<210>  17
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B synthetic polypeptide

<400>  17

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
65                  70                  75                  80  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  18
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B synthetic polynucleotide

<400>  18
ggcgcgccaa gtcccgctgg aagcccaact agcaccgaag aggggacctc agagtccgcc       60

acccccgagt ccggccctgg ctctgagcct gccactagcg gctccgagac tcctggcaca      120

tccgaaagcg ctacacccga gagtggaccc ggcacctcta ccgagcccag tgagggctcc      180

gcccctggaa caagcaccga gcccagcgaa ggcagcgccc cagggacctc cacagagccc      240

agtgaaggca gtgctcctgg caccagcacc gaaccaagcg agggctctgc acccgggacc      300

tccaccgagc caagcgaagg ctctgcccct ggcacttcca ccgagcccag cgaaggcagc      360

gcccctggga gccccgctgg ctctcccacc agcactgagg agggcacatc taccgaacca      420

agtgaaggct ctgcaccagg tgcctcgagc                                       450


<210>  19
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A synthetic polypeptide

<400>  19

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  20
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A synthetic polynucleotide

<400>  20
ggcgcgccaa cgtccgaaag tgctacccct gagtcaggcc ctggtagtga gcctgccaca       60

agcggaagcg aaactccggg gacctcagag tctgccactc ccgaatcggg gccaggctct      120

gaaccggcca cttcagggag cgaaacacca ggaacatcgg agagcgctac cccggagagc      180

gggccaggaa ctagtactga gcctagcgag ggaagtgcac ctggtacaag cgagtccgcc      240

acacccgagt ctggccctgg ctctccagcg ggctcaccca cgagcactga agagggctct      300

cccgctggca gcccaacgtc gacagaagaa ggatcaccag caggctcccc cacatcaaca      360

gaggagggta catcagaatc tgctactccc gagagtggac ccggtacctc cactgagccc      420

agcgagggga gtgcaccagg tgcctcgagc                                       450


<210>  21
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A synthetic polypeptide

<400>  21

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            100                 105                 110         


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
    130                 135                 140                 


<210>  22
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A synthetic polynucleotide

<400>  22
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  23
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B synthetic polypeptide

<400>  23

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
    50                  55                  60                  


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 
            100                 105                 110         


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  24
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B synthetic polynucleotide

<400>  24
ggcgcgccaa catctaccga gccttccgaa ggctctgccc ctgggacctc agaatctgca       60

acccctgaaa gcggccctgg aacctccgaa agtgccactc ccgagagcgg cccagggaca      120

agcgagtcag caacccctga gtctggaccc ggcagcgagc ctgcaacctc tggctcagag      180

actcccggct cagaacccgc tacctcaggc tccgagacac ccggctctcc tgctgggagt      240

cccacttcca ccgaggaagg aacatccact gagcctagtg agggctctgc ccctggaacc      300

agcacagagc caagtgaggg cagtgcacca ggatccgagc cagcaaccag cgggtccgag      360

actcccggga cctctgagtc tgccacccca gagagcggac ccggcacttc aaccgagccc      420

tccgaaggat cagcaccagg tgcctcgagc                                       450


<210>  25
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1synthetic polypeptide

<400>  25

Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 
1               5                   10                  15      


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        35                  40                  45              


Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
65                  70                  75                  80  


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
                85                  90                  95      


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 
            100                 105                 110         


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 
        115                 120                 125             


Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 
    130                 135                 140                 


<210>  26
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1 synthetic polynucleotide

<400>  26
ggcgcgccac ccgggtcgtc cccgtcggcg tccaccggaa cagggccagg gtcatccccg       60

tcagcgtcga ctgggacggg acccgggaca cccggttcgg ggactgcatc ctcctcgcct      120

ggttcgtcca ccccgtcagg agccacgggt tcgccgggaa gcagcccaag cgcatccact      180

ggtacagggc ctggggcttc accgggtact tcatccacgg ggtcaccggg aacgcccgga      240

tcggggacgg cttcctcatc accaggatcg tcaacaccct cgggcgcaac gggcagcccc      300

ggaacccctg gttcgggtac ggcgtcgtcg agccccggtg cgagcccggg aacaagctcg      360

acaggatcgc ctggggcgtc acccggcacg tcgagcacag gcagccccgg aacccctgga      420

tcgggaaccg cgtcgtcaag cgcctcgagc                                       450


<210>  27
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A synthetic polypeptide

<400>  27

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
            100                 105                 110         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  28
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A synthetic polynucleotide

<400>  28
ggcgcgccag gtgcctcgcc gggaacatca tcaactggtt cacccgggtc atccccctcg       60

gcctcaaccg ggacgggtcc cggctcatcc cccagcgcca gcactggaac aggtcctggc      120

actcctggtt ccggtacggc atcgtcatcc ccgggaagct caacaccgtc cggagcgaca      180

ggatcacctg gctcgtcacc ttcggcgtca actggaacgg ggccaggggc ctcacccgga      240

acgtcctcga ctgggtcgcc tggtacgccg ggatcaggaa cggcctcatc ctcgcctggg      300

tcctcaacgc cctcgggtgc gactggttcg ccgggaactc ctggctcggg gacggcctcg      360

tcgtcgcctg gggcatcacc ggggacgagc tccacggggt cccctggagc gtcaccgggg      420

acctcctcga caggtagccc ggcctcgagc                                       450


<210>  29
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B synthetic polypeptide

<400>  29

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
65                  70                  75                  80  


Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 
            100                 105                 110         


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  30
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B synthetic polynucleotide

<400>  30
ggcgcgccag gtacaccggg cagcggcacg gcttcgtcgt cacccggctc gtccacaccg       60

tcgggagcta cgggaagccc aggagcgtca ccgggaacgt cgtcaacggg gtcaccgggt      120

acgccaggta gcggcacggc cagcagctcg ccaggttcat cgaccccgtc gggagcgact      180

gggtcgcccg gatcaagccc gtcagcttcc actggaacag gacccgggtc gtcgccgtca      240

gcctcaacgg ggacaggacc tggttcatcg acgccgtcag gggcgacagg ctcgcccgga      300

tcgtcaacac cctcgggggc aacggggagc cctggtgcgt cgcctggaac ctcatccacc      360

ggaagcccgg gggcctcgcc gggtacgagc tccacgggat cgcccggagc gtcccccgga      420

acttcaagca cagggagccc tgcctcgagc                                       450


<210>  31
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C synthetic polypeptide

<400>  31

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 
1               5                   10                  15      


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 
    50                  55                  60                  


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                85                  90                  95      


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  32
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C synthetic polynucleotide

<400>  32
ggcgcgccag gtacacccgg atcgggtaca gcgtcatcga gccccggtgc gtcacctggt       60

acgtcgagca cggggtcgcc aggggcgtcc cctgggacgt cctcaacagg ctcgcccggt      120

gcgtcacccg gcacgtcgtc cacgggttca cctggtagct ccccttccgc gtccactggc      180

accgggcctg gaactccggg gagcggcaca gcgagctcgt cgccgggagc atcgcctggg      240

acatcgagca ccgggtcgcc aggagcatcg cccggaacat ccagcacagg aagccccggc      300

gcgtcgcccg ggacatcaag cacaggttcc ccgggatcga gcacgccgtc cggagccact      360

ggatcaccag ggagctcgac accttccggc gcaacgggat cgcccggagc cagcccgggt      420

acgtcaagca ctggctcccc tgcctcgagc                                       450


<210>  33
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F synthetic polypeptide

<400>  33

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
                85                  90                  95      


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  34
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F synthetic polynucleotide

<400>  34
ggcgcgccag gctccagccc ctccgcgagc acgggaaccg gaccaggttc gtcaccctca       60

gcatcaacgg ggacgggacc gggggcgtca ccaggaacgt cctccaccgg ctcgccgggt      120

gcatcacccg gaacgtcatc gaccggatcg ccagggagct cgacgccatc aggcgcaaca      180

ggatcacctg gctcaagccc tagcgcgtca accggcacgg gtccgggtgc ctcccctggc      240

acgtccagca ccggatcacc cggatcgagc ccatccgcct caaccggaac cggacccggt      300

acaccagggt cgggaacagc ctcctcgtca ccaggctcct caaccccctc gggagccacg      360

ggttcgcccg gttcgtcaac gccttccgga gcaactggta gccccggagc atcgccagga      420

acttcgagca cggggtcgcc cgcctcgagc                                       450


<210>  35
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


<210>  36
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 1

<400>  37

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 2

<400>  38

Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ser 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 3

<400>  39

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser Ser 
            20  


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 4

<400>  40

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 5

<400>  41

Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ser Pro Ala 
            20  


<210>  42
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 6

<400>  42

Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala Pro Pro Ala 
            20                  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, PAS peptide 7

<400>  43

Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 
1               5                   10                  15      


Ser Ala Ala Ala 
            20  


<210>  44
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  45
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN-AE288-1 synthetic polypeptide

<400>  45

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
1               5                   10                  15      


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        35                  40                  45              


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
65                  70                  75                  80  


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
145                 150                 155                 160 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            180                 185                 190         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
        195                 200                 205             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    210                 215                 220                 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
                245                 250                 255     


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


<210>  46
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN-AG228-2 synthetic polypeptide

<400>  46

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 
            20                  25                  30          


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 
    50                  55                  60                  


Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 
65                  70                  75                  80  


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
                85                  90                  95      


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 
            100                 105                 110         


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
    130                 135                 140                 


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 
145                 150                 155                 160 


Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 
                165                 170                 175     


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
            180                 185                 190         


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
        195                 200                 205             


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala 
    210                 215                 220                 


Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
225                 230                 235                 240 


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 
                245                 250                 255     


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            260                 265                 270         


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        275                 280                 285             


<210>  47
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN-AG228-1 synthetic polypeptide

<400>  47

Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 
1               5                   10                  15      


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        35                  40                  45              


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 
    50                  55                  60                  


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
65                  70                  75                  80  


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
                85                  90                  95      


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 
            100                 105                 110         


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 
        115                 120                 125             


Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 
145                 150                 155                 160 


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 
                165                 170                 175     


Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 
            180                 185                 190         


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 
        195                 200                 205             


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 
    210                 215                 220                 


Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 
225                 230                 235                 240 


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 
                245                 250                 255     


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
            260                 265                 270         


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        275                 280                 285             


<210>  48
<211>  264
<212>  PRT
<213>  Unknown

<220>
<223>  GFP protein sequence (Genbank ID AAG34521.1)

<400>  48

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Ser Arg 
225                 230                 235                 240 


Thr Ser Gly Ser Pro Gly Leu Gln Glu Phe Asp Ile Lys Leu Ile Asp 
                245                 250                 255     


Thr Val Asp Leu Glu Ser Cys Asn 
            260                 


<210>  49
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  50
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg 
1               5                   10                  15      


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            20                  25                  30          


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        35                  40                  45              


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    50                  55                  60                  


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
65                  70                  75                  80  


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                85                  90                  95      


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            100                 105                 110         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        115                 120                 125             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    130                 135                 140                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            180                 185                 190         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
        195                 200                 205             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    210                 215                 220                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
225                 230                 235                 240 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                245                 250                 255     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            260                 265                 270         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        275                 280                 285             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    290                 295                 300                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
305                 310                 315                 320 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                325                 330                 335     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            340                 345                 350         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        355                 360                 365             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    370                 375                 380                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
385                 390                 395                 400 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                405                 410                 415     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            420                 425                 430         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        435                 440                 445             


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
    450                 455                 460                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
465                 470                 475                 480 


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
                485                 490                 495     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            500                 505                 510         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        515                 520                 525             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    530                 535                 540                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
545                 550                 555                 560 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                565                 570                 575     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590     


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence. Sequence repeated n times, where n=0 , 1,2 ,3
       ,4 or more.

<400>  51

Gly Gly Gly Ser 
1               


<210>  52
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  53
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210>  54
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val Lys 
            20      


<210>  55
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Glu Trp Trp Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Glu Glu Asp 
            20  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide, Cysteine-containing peptide

<400>  56

Gly Gly Gly Ser Gly Cys Gly Gly Gly Ser 
1               5                   10  


<210>  57
<211>  4544
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Pro  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  58
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Biotin Acceptor Peptide (BAP)

<400>  58

Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Lipoate Acceptor Peptide 2 (LAP2)

<400>  59

Gly Phe Glu Ile Asp Lys Val Trp Tyr Asp Leu Asp Ala 
1               5                   10              


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide. HAPylation motif. Sequence repeated n times, 
       where n= 1 to 400.

<400>  60

Gly Gly Gly Gly Ser 
1               5   


<210>  61
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Alternative linker peptide sequence

<400>  61

Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
1               5                   10          


<210>  62
<211>  29
<212>  PRT
<213>  Unknown

<220>
<223>  CTP peptide

<400>  62

Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
1               5                   10                  15      


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25                  


<210>  63
<211>  2351
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Arg 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  64
<211>  2351
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  65
<211>  2351
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Ser Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  66
<211>  2351
<212>  PRT
<213>  Pan troglodytes

<400>  66

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Val Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Phe His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Arg Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Gln Ser Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Arg Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Glu Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Ser Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Arg Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Ala Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Glu Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Gly 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Glu Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Ile 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Gly Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His His Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  67
<211>  2352
<212>  PRT
<213>  Nomascus leucogenys

<400>  67

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Pro Gly Glu Leu Pro Val Asp Ile Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Asn Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ser Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Thr Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Val Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro Tyr Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln His His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Leu Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Asn Ser Leu Arg Pro Pro Asn Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Ile Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Glu Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Val 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Phe  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Val Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Gln Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Pro Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Glu Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Val  Asn Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Gln Asp Val  Arg Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Gly  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Arg Lys  Glu Thr Leu Ile Arg  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Pro Arg Thr Thr Arg  Ile Ser Pro Asn Pro  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Gly  Lys Arg Ala Leu Lys  Gln Leu Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Glu Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Phe Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser Tyr Ser 
    1385                 1390                 1395             


Ile Thr  Gln Ala Asn Arg Ser  Pro Leu Pro Thr Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Asp Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Leu Ala Pro Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Arg 
    1445                 1450                 1455             


Lys Asn  Lys Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Tyr 
    1475                 1480                 1485             


Ser Val  Thr Tyr Lys Lys Val  Glu Asn Thr Val Leu  Leu Lys Pro 
    1490                 1495                 1500             


Ala Leu  Pro Lys Thr Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val 
    1505                 1510                 1515             


His Ile  Tyr Gln Lys Glu Leu  Phe Pro Thr Glu Thr  Ser Asn Gly 
    1520                 1525                 1530             


Ser Pro  Gly His Leu Asp Leu  Val Glu Gly Ser Leu  Leu Gln Glu 
    1535                 1540                 1545             


Thr Glu  Gly Ala Ile Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys 
    1550                 1555                 1560             


Ile Pro  Phe Leu Arg Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro 
    1565                 1570                 1575             


Ser Lys  Leu Leu Gly Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr 
    1580                 1585                 1590             


Gln Ile  Pro Lys Glu Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu 
    1595                 1600                 1605             


Lys Thr  Ala Phe Lys Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala 
    1610                 1615                 1620             


Cys Glu  Ser Asn His Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn 
    1625                 1630                 1635             


Lys Pro  Glu Ile Glu Ala Thr  Trp Ala Lys Gln Gly  Gly Thr Glu 
    1640                 1645                 1650             


Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu Lys Arg  His Gln Arg 
    1655                 1660                 1665             


Glu Ile  Thr Leu Thr Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp 
    1670                 1675                 1680             


Tyr Asp  Asp Thr Ile Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp 
    1685                 1690                 1695             


Ile Tyr  Asp Glu Asp Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys 
    1700                 1705                 1710             


Lys Thr  Arg His Tyr Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp 
    1715                 1720                 1725             


Tyr Gly  Thr Ser Ser Ser Pro  His Val Leu Arg Asn  Arg Ala Gln 
    1730                 1735                 1740             


Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe 
    1745                 1750                 1755             


Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn 
    1760                 1765                 1770             


Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu 
    1775                 1780                 1785             


Asp Asn  Ile Met Val Thr Phe  Lys Asn Gln Ala Ser  Arg Pro Tyr 
    1790                 1795                 1800             


Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln 
    1805                 1810                 1815             


Gly Ala  Glu Leu Arg Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys 
    1820                 1825                 1830             


Thr Tyr  Phe Trp Lys Val Gln  His His Met Ala Pro  Thr Lys Asp 
    1835                 1840                 1845             


Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu 
    1850                 1855                 1860             


Glu Lys  Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
    1865                 1870                 1875             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1880                 1885                 1890             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1895                 1900                 1905             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1910                 1915                 1920             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1925                 1930                 1935             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1940                 1945                 1950             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1955                 1960                 1965             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1970                 1975                 1980             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Val  Tyr Asn Leu 
    1985                 1990                 1995             


Tyr Pro  Gly Val Phe Lys Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    2000                 2005                 2010             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    2015                 2020                 2025             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    2030                 2035                 2040             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    2045                 2050                 2055             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    2060                 2065                 2070             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    2075                 2080                 2085             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    2090                 2095                 2100             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    2105                 2110                 2115             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Gln  Lys Trp Gln 
    2120                 2125                 2130             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    2135                 2140                 2145             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    2150                 2155                 2160             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    2165                 2170                 2175             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    2180                 2185                 2190             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    2195                 2200                 2205             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    2210                 2215                 2220             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    2225                 2230                 2235             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    2240                 2245                 2250             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Ile Thr Thr  Gln Gly Val 
    2255                 2260                 2265             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Val Ser 
    2270                 2275                 2280             


Ser Ser  Gln Asp Gly His His  Trp Thr Leu Phe Phe  Gln Asn Gly 
    2285                 2290                 2295             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    2300                 2305                 2310             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Val 
    2315                 2320                 2325             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    2330                 2335                 2340             


Leu Gly  Cys Glu Ala Gln Glu  Leu Tyr 
    2345                 2350         


<210>  68
<211>  2351
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Arg Lys Ser  Ser Phe His Ser Phe  Leu Leu Cys 
    2090                 2095                 2100             


Ile Pro  Gln Leu His Thr His  Met His Ile Ser Thr  Leu Val Thr 
    2105                 2110                 2115             


Ala Ser  Leu Ala His Leu Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  69
<211>  2336
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  69

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Val Cys Ile Leu Gln Leu 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met His Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Ser Pro Pro Arg Met Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Ile Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Val Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Ala Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Ile Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Thr 
        195                 200                 205             


Thr Gln Ile Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Thr Trp His Ser Gly Thr Pro Ala Met Asp Ser Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser 
                245                 250                 255     


Leu Pro Gly Leu Ile Gly Cys His Arg Lys Gln Val Tyr Trp His Val 
            260                 265                 270         


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
        275                 280                 285             


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
    290                 295                 300                 


Pro Ile Thr Phe Leu Thr Ala Glu Thr Leu Leu Met Asp Leu Gly Gln 
305                 310                 315                 320 


Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu 
                325                 330                 335     


Ala Tyr Ile Lys Val Asp Lys Cys Pro Glu Glu Pro Gln Leu Arg Met 
            340                 345                 350         


Lys Asn His Glu Glu Glu Glu Tyr Tyr Asp Asp Asp Val Lys Asp Ser 
        355                 360                 365             


Glu Met Asp Val Phe Arg Phe Asp Asp Asp Asn Ser Ala Ser Tyr Ile 
    370                 375                 380                 


Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Ile His Tyr 
385                 390                 395                 400 


Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser Val Ala Thr 
                405                 410                 415     


Pro Asp Asp Arg Ser Tyr Gln Ser Gln Tyr Leu Asn Asn Gly Pro Gln 
            420                 425                 430         


Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp 
        435                 440                 445             


Glu Thr Phe Lys Thr Arg Glu Thr Met Gln Tyr Glu Ser Gly Ile Leu 
    450                 455                 460                 


Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe 
465                 470                 475                 480 


Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr 
                485                 490                 495     


Asp Val Ser Pro Leu His Ser Gly Arg Leu Ser Lys Gly Met Lys His 
            500                 505                 510         


Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp 
        515                 520                 525             


Lys Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu 
    530                 535                 540                 


Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Asp Arg Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln 
                565                 570                 575     


Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser 
            580                 585                 590         


Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Thr Glu Asn Met Gln Arg 
        595                 600                 605             


Phe Leu Pro Glu Ala Ala Gly Val Gln Pro Gln Asp Pro Glu Phe Gln 
    610                 615                 620                 


Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu 
625                 630                 635                 640 


Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser 
                645                 650                 655     


Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe Phe Ser Gly Tyr Thr 
            660                 665                 670         


Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe 
        675                 680                 685             


Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val 
    690                 695                 700                 


Ile Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu 
705                 710                 715                 720 


Leu Lys Val Ser Thr Cys Asp Arg Asn Ile Gly Asp Tyr Tyr Glu Asp 
                725                 730                 735     


Ile Tyr Glu Asp Met Pro Ile His Leu Leu Asn Glu Asn Asn Gly Ile 
            740                 745                 750         


Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Ala Arg Thr Arg Gln 
        755                 760                 765             


Lys Gln Phe Thr Ala Thr Thr Ile Pro Glu Asn Asp Met Glu Asn Ile 
    770                 775                 780                 


Asp Ser Pro Leu Gly Glu Arg Met Gln Met Ala Lys Val Gln Ser Val 
785                 790                 795                 800 


Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln Ser Pro Thr Pro His 
                805                 810                 815     


Gly Leu Ala Leu Ser Asp Leu Gln Glu Ser Thr Tyr Glu Ala Val Ser 
            820                 825                 830         


Asp Asp Asn Ser Pro Gly Ala Thr Asp Asn Asn Glu Asp Leu Tyr Lys 
        835                 840                 845             


Val Ala His Leu Thr Pro Glu Leu His Tyr Ser Gly Gly Ile Ile Phe 
    850                 855                 860                 


Thr Pro Glu Pro Gly Leu Lys Leu Arg Leu Asn Glu Asn Leu Glu Ile 
865                 870                 875                 880 


Thr Thr Pro Val Glu Phe Asn Glu Leu Asp Leu Lys Asp Ser Ser Ser 
                885                 890                 895     


Ser His Asn Leu Met Thr Pro Pro Thr Ile Pro Ser Asp Asn Leu Ala 
            900                 905                 910         


Gly Thr Glu Lys Ser Gly Ser Leu Gly Ser Pro Asn Met Pro Val His 
        915                 920                 925             


Val Asp Ser Gln Leu Gly Thr Ala Ile Leu Asp Lys Lys Leu Ser Ile 
    930                 935                 940                 


Val Ile Asp Ser Gly Ile Pro Leu Asn Leu Asn Glu Arg Asn Asn Asn 
945                 950                 955                 960 


Pro Met Leu Leu Glu Val Asp Leu Met Asn Asn Gln Glu Ser Ser Leu 
                965                 970                 975     


Gly Lys Asn Ile Ser Met Asp Ser Asp Lys Leu Phe Lys Glu Lys Arg 
            980                 985                 990         


Val His Glu Ser Ala Ser Leu Thr  Lys Asp Asn Ala Pro  Phe Lys Val 
        995                 1000                 1005             


Pro Ile  Ser Leu Leu Lys Thr  Asn Lys Leu Ser His  Asn Ser Thr 
    1010                 1015                 1020             


Thr Thr  Lys Glu Thr His Thr  Asp Gly Pro Thr Leu  Phe Ile Glu 
    1025                 1030                 1035             


Asn Ser  Thr Ser Val Trp Gln  Asn Ile Ile Leu Glu  Asn Asp Thr 
    1040                 1045                 1050             


Glu Phe  Gln Glu Val Thr Ser  Leu Ile Tyr Asp Glu  Met Leu Met 
    1055                 1060                 1065             


Ser Lys  Asn Thr Thr Ala Leu  Arg Leu Asn His Glu  Leu Asn Lys 
    1070                 1075                 1080             


Asn Thr  Ser Ser Glu Asp Val  Lys Met Val His Gln  Lys Lys Glu 
    1085                 1090                 1095             


Gly Leu  Val Thr Pro Asp Ala  Glu Asn Pro Asp Met  Ser Phe Phe 
    1100                 1105                 1110             


Lys Ile  Leu Leu Leu Pro Asp  Ser Pro Asn Trp Phe  Lys Arg Thr 
    1115                 1120                 1125             


Tyr Gly  Lys Asn Ser Leu Asn  Ser Ala Gln Gly Pro  Gly Pro Lys 
    1130                 1135                 1140             


Lys Leu  Ile Ser Leu Gly Ser  Gly Lys Ser Val Lys  Asp Glu Asn 
    1145                 1150                 1155             


Phe Leu  Ser Glu Lys Asn Lys  Val Ala Val Gly Glu  Asp Ala Phe 
    1160                 1165                 1170             


Thr Lys  Asp Thr Gly Leu Lys  Glu Met Ile Leu Pro  Ser Asn Gly 
    1175                 1180                 1185             


Ser Met  Phe Val Thr Asn Leu  Thr Asn Val Trp Glu  Asn Asp Thr 
    1190                 1195                 1200             


His Asn  Gln Glu Lys Asn Phe  Gln Glu Glu Val Glu  Lys Lys Glu 
    1205                 1210                 1215             


Glu Leu  Val Gln Glu Asn Val  Val Met Pro Gln Val  Tyr Thr Met 
    1220                 1225                 1230             


Asn Gly  Thr Lys Asn Phe Leu  Lys Lys Leu Phe Leu  Val Ser Thr 
    1235                 1240                 1245             


Ser Gln  Asn Ile Gly Leu Asp  Asp Thr Arg Pro Leu  Asn Asp Ser 
    1250                 1255                 1260             


Val Asn  Arg Ala Asp Ile Gln  Ile Thr His Phe Ser  Lys Arg Lys 
    1265                 1270                 1275             


Glu Glu  Glu Glu Asp Asn Leu  Lys Gly Leu Gly Asn  Gln Thr Lys 
    1280                 1285                 1290             


Gln Met  Val Asp Lys Tyr Ser  Ser Thr Thr Arg Met  Ser Pro Asn 
    1295                 1300                 1305             


Leu Ser  Gln His Asn Ala Ile  Asn Glu Arg Gly Lys  Gln Ala Leu 
    1310                 1315                 1320             


Lys Gln  Phe Thr His Ser Leu  Glu Glu Ile Glu Ile  Glu Arg Gly 
    1325                 1330                 1335             


Ile Ser  Val Asp Asp Thr Ser  Thr Gln Gln Ser Lys  Asn Thr Lys 
    1340                 1345                 1350             


Tyr Leu  Thr Gln Ser Ala Leu  Thr Gln Met Asn Cys  Asn Glu Lys 
    1355                 1360                 1365             


Lys Lys  Val Val Thr Gln Ser  Pro Thr Ser Asp Gly  Pro Leu Arg 
    1370                 1375                 1380             


Ser His  Asn Ile Ile His Met  Asn Gly Ser Val Leu  Pro Thr Ala 
    1385                 1390                 1395             


Asn Leu  Ser Val Phe Pro Ser  Ile Arg Pro Thr Asp  Leu Thr Lys 
    1400                 1405                 1410             


Ile Pro  Ser Gln Asn Asn Ser  Pro His Leu Leu Thr  Pro Ala Tyr 
    1415                 1420                 1425             


Asn Tyr  Lys Phe Met Glu Arg  Ser Pro Gly Val Gln  Lys Asn Asn 
    1430                 1435                 1440             


His Leu  Leu Gln Asp Ala Lys  Lys Asn Asn Leu Ser  Leu Ala Ile 
    1445                 1450                 1455             


Leu Pro  Leu Glu Val Val Arg  Asp Gln Glu Lys Val  Gly Ser Leu 
    1460                 1465                 1470             


Gly Thr  Ser Ala Thr Asn Ser  Val Met Tyr Lys Lys  Phe Asp Asn 
    1475                 1480                 1485             


Val Val  Leu Leu Lys Pro Gly  Leu Pro Glu Ala Ser  Ser Asn Val 
    1490                 1495                 1500             


Glu Leu  Leu Pro Lys Val Pro  Ile His Gln Glu Asp  Leu Phe Ser 
    1505                 1510                 1515             


Glu Val  Thr Ser Asn Gly Ser  Pro Asp His Leu Asp  Leu Val Glu 
    1520                 1525                 1530             


Glu Ser  Leu Gln Lys Thr Gln  Gly Ala Val Lys Trp  Asn Lys Val 
    1535                 1540                 1545             


Asn Arg  Pro Gly Lys Val Leu  Phe Leu Lys Glu Ala  Ala Glu Asn 
    1550                 1555                 1560             


Pro Glu  Lys Thr Pro Ser Lys  Leu Met Met Pro Leu  Val Trp Asp 
    1565                 1570                 1575             


Asn Gln  Tyr Val Thr Gln Thr  Pro Lys Lys Glu Cys  Lys Ser Gln 
    1580                 1585                 1590             


Glu Lys  Ser Pro Lys Asn Thr  Asp Phe Lys Thr Lys  Asp Ser Ile 
    1595                 1600                 1605             


Leu Ser  Leu Thr Pro Cys Glu  Asn Asn Tyr Ala Ile  Glu Thr Met 
    1610                 1615                 1620             


Asn Glu  Gly Gln Asp Arg Leu  Pro Arg Glu Ala Ser  Trp Ala Lys 
    1625                 1630                 1635             


Gln Gly  Gly Thr Gly Ser Leu  Cys Ser Gln Asn Pro  Ser Asp Leu 
    1640                 1645                 1650             


Ile His  Gln Glu Arg Lys Ile  Thr Leu Thr Thr Ile  Gln Ser Gln 
    1655                 1660                 1665             


Gln Glu  Glu Ile Tyr Tyr Asp  Asp Thr Ile Ser Ser  Glu Ile Lys 
    1670                 1675                 1680             


Arg Glu  Asp Phe Asp Ile Tyr  Gly Glu Asp Glu Ile  Gln Gly Pro 
    1685                 1690                 1695             


Arg Ser  Phe Gln Lys Arg Thr  Arg His Tyr Phe Ile  Ala Ala Val 
    1700                 1705                 1710             


Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Thr Ser Pro  His Ala Leu 
    1715                 1720                 1725             


Arg Asn  Ser Val Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1730                 1735                 1740             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1745                 1750                 1755             


His Leu  Gly Ile Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1760                 1765                 1770             


Asn Ile  Val Val Thr Phe Lys  Asn Met Ala Ser Arg  Pro Tyr Ser 
    1775                 1780                 1785             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Lys Asp Asp Gln  Arg Gln Gly 
    1790                 1795                 1800             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1805                 1810                 1815             


Tyr Phe  Trp Glu Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1820                 1825                 1830             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1835                 1840                 1845             


Lys Asp  Met His Ser Gly Leu  Ile Gly Pro Leu Leu  Ile Cys His 
    1850                 1855                 1860             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1865                 1870                 1875             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1880                 1885                 1890             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1895                 1900                 1905             


Ile Gln  Thr Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1910                 1915                 1920             


Ala Ile  Asn Gly Tyr Val Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1925                 1930                 1935             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1940                 1945                 1950             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1955                 1960                 1965             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Val Tyr  Asn Leu Tyr 
    1970                 1975                 1980             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    1985                 1990                 1995             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2000                 2005                 2010             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Lys Asn Cys  Gln Ile Pro 
    2015                 2020                 2025             


Leu Gly  Met Ala Ser Gly His  Ile Gln Asp Phe Gln  Ile Thr Ala 
    2030                 2035                 2040             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2045                 2050                 2055             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Asp  Pro Phe Ser 
    2060                 2065                 2070             


Trp Ile  Lys Val Asp Leu Leu  Thr Pro Met Ile Ile  His Gly Ile 
    2075                 2080                 2085             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2090                 2095                 2100             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2105                 2110                 2115             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2120                 2125                 2130             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2135                 2140                 2145             


Ile Ala  Gln Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2150                 2155                 2160             


Ser Thr  Leu Arg Met Glu Leu  Ile Gly Cys Asp Leu  Asn Ser Cys 
    2165                 2170                 2175             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ser Gln 
    2180                 2185                 2190             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Thr  Thr Trp Ser 
    2195                 2200                 2205             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Lys Thr  Asn Ala Trp 
    2210                 2215                 2220             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Leu 
    2225                 2230                 2235             


Arg Lys  Thr Met Lys Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys 
    2240                 2245                 2250             


Ser Leu  Leu Thr Ser Met Tyr  Val Thr Glu Phe Leu  Ile Ser Ser 
    2255                 2260                 2265             


Ser Gln  Asp Gly His His Trp  Thr Leu Val Leu Gln  Lys Gly Lys 
    2270                 2275                 2280             


Leu Lys  Val Phe Lys Gly Asn  Gln Asp Ser Phe Thr  Pro Val Leu 
    2285                 2290                 2295             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2300                 2305                 2310             


Pro Lys  Ser Trp Val His Gln  Ile Ala Leu Arg Leu  Glu Val Leu 
    2315                 2320                 2325             


Gly Cys  Glu Ala Gln Gln Leu  Tyr 
    2330                 2335     


<210>  70
<211>  2343
<212>  PRT
<213>  Canis lupus familiaris

<400>  70

Met Gln Val Glu Leu Tyr Thr Cys Cys Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Leu Ser Ala Thr Arg Lys Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Ala Leu His Ala Asp Thr 
        35                  40                  45              


Ser Phe Ser Ser Arg Val Pro Gly Ser Leu Pro Leu Thr Thr Ser Val 
    50                  55                  60                  


Thr Tyr Arg Lys Thr Val Phe Val Glu Phe Thr Asp Asp Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Val Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Lys Glu Lys Glu 
    130                 135                 140                 


Asp Asp Asn Val Ile Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Phe Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu Gln Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Ala Ser Leu Thr Gln Ala Glu 
225                 230                 235                 240 


Ala Gln His Glu Leu His Thr Ile Asn Gly Tyr Val Asn Arg Ser Leu 
                245                 250                 255     


Pro Gly Leu Thr Val Cys His Lys Arg Ser Val Tyr Trp His Val Ile 
            260                 265                 270         


Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His 
        275                 280                 285             


Thr Phe Leu Val Gly Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro 
    290                 295                 300                 


Ile Thr Phe Leu Thr Ala Gln Thr Phe Leu Met Asp Leu Gly Gln Phe 
305                 310                 315                 320 


Leu Leu Phe Cys His Ile Pro Ser His Gln His Asp Gly Met Glu Ala 
                325                 330                 335     


Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys 
            340                 345                 350         


Asn Asn Glu Asp Lys Asp Tyr Asp Asp Gly Leu Tyr Gly Ser Asp Met 
        355                 360                 365             


Asp Val Val Ser Phe Asp Asp Asp Ser Ser Ser Pro Phe Ile Gln Ile 
    370                 375                 380                 


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
385                 390                 395                 400 


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser Gly Pro Thr Pro Asn 
                405                 410                 415     


Asp Arg Ser His Lys Asn Leu Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
            420                 425                 430         


Gly Lys Lys Tyr Lys Lys Val Arg Phe Val Ala Tyr Thr Asp Glu Thr 
        435                 440                 445             


Phe Lys Thr Arg Glu Ala Ile Gln Tyr Glu Ser Gly Ile Leu Gly Pro 
    450                 455                 460                 


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Lys 
465                 470                 475                 480 


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Asn Tyr Val 
                485                 490                 495     


Thr Pro Leu His Thr Gly Arg Leu Pro Lys Gly Val Lys His Leu Lys 
            500                 505                 510         


Asp Met Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
        515                 520                 525             


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
    530                 535                 540                 


Tyr Tyr Ser Ser Phe Ile Asn Leu Glu Arg Asp Leu Ala Ser Gly Leu 
545                 550                 555                 560 


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
                565                 570                 575     


Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Leu 
            580                 585                 590         


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asp Met Gln Arg Phe Leu 
        595                 600                 605             


Pro Asn Ala Asp Val Val Gln Pro His Asp Pro Glu Phe Gln Leu Ser 
    610                 615                 620                 


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Asn Leu Gln Leu 
625                 630                 635                 640 


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly 
                645                 650                 655     


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
            660                 665                 670         


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
        675                 680                 685             


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly 
    690                 695                 700                 


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
705                 710                 715                 720 


Val Ser Ser Cys Asn Arg Asn Ile Asp Asp Tyr Tyr Glu Asp Thr Tyr 
                725                 730                 735     


Glu Asp Ile Pro Thr Pro Leu Leu Asn Glu Asn Asn Val Ile Lys Pro 
            740                 745                 750         


Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Lys Glu Lys Gln 
        755                 760                 765             


Leu Lys Ala Thr Thr Thr Pro Glu Asn Asp Ile Glu Lys Ile Asp Leu 
    770                 775                 780                 


Gln Ser Gly Glu Arg Thr Gln Leu Ile Lys Ala Gln Ser Val Ser Ser 
785                 790                 795                 800 


Ser Asp Leu Leu Met Leu Leu Gly Gln Asn Pro Thr Pro Arg Gly Leu 
                805                 810                 815     


Phe Leu Ser Asp Leu Arg Glu Ala Thr Asp Arg Ala Asp Asp His Ser 
            820                 825                 830         


Arg Gly Ala Ile Glu Arg Asn Lys Gly Pro Pro Glu Val Ala Ser Leu 
        835                 840                 845             


Arg Pro Glu Leu Arg His Ser Glu Asp Arg Glu Phe Thr Pro Glu Pro 
    850                 855                 860                 


Glu Leu Gln Leu Arg Leu Asn Glu Asn Leu Gly Thr Asn Thr Thr Val 
865                 870                 875                 880 


Glu Leu Lys Lys Leu Asp Leu Lys Ile Ser Ser Ser Ser Asp Ser Leu 
                885                 890                 895     


Met Thr Ser Pro Thr Ile Pro Ser Asp Lys Leu Ala Ala Ala Thr Glu 
            900                 905                 910         


Lys Thr Gly Ser Leu Gly Pro Pro Asn Met Ser Val His Phe Asn Gly 
        915                 920                 925             


His Leu Gly Thr Ile Val Phe Gly Asn Asn Ser Ser His Leu Ile Gln 
    930                 935                 940                 


Ser Gly Val Pro Leu Glu Leu Ser Glu Glu Asp Asn Asp Ser Lys Leu 
945                 950                 955                 960 


Leu Glu Ala Pro Leu Met Asn Ile Gln Glu Ser Ser Leu Arg Glu Asn 
                965                 970                 975     


Val Leu Ser Met Glu Ser Asn Arg Leu Phe Lys Glu Glu Arg Ile Arg 
            980                 985                 990         


Gly Pro Ala Ser Leu Ile Lys Asp  Asn Ala Leu Phe Lys  Val Asn Ile 
        995                 1000                 1005             


Ser Ser  Val Lys Thr Asn Arg  Ala Pro Val Asn Leu  Thr Thr Asn 
    1010                 1015                 1020             


Arg Lys  Thr Arg Val Ala Ile  Pro Thr Leu Leu Ile  Glu Asn Ser 
    1025                 1030                 1035             


Thr Ser  Val Trp Gln Asp Ile  Met Leu Glu Arg Asn  Thr Glu Phe 
    1040                 1045                 1050             


Lys Glu  Val Thr Ser Leu Ile  His Asn Glu Thr Phe  Met Asp Arg 
    1055                 1060                 1065             


Asn Thr  Thr Ala Leu Gly Leu  Asn His Val Ser Asn  Lys Thr Thr 
    1070                 1075                 1080             


Leu Ser  Lys Asn Val Glu Met  Ala His Gln Lys Lys  Glu Asp Pro 
    1085                 1090                 1095             


Val Pro  Leu Arg Ala Glu Asn  Pro Asp Leu Ser Ser  Ser Lys Ile 
    1100                 1105                 1110             


Pro Phe  Leu Pro Asp Trp Ile  Lys Thr His Gly Lys  Asn Ser Leu 
    1115                 1120                 1125             


Ser Ser  Glu Gln Arg Pro Ser  Pro Lys Gln Leu Thr  Ser Leu Gly 
    1130                 1135                 1140             


Ser Glu  Lys Ser Val Lys Asp  Gln Asn Phe Leu Ser  Glu Glu Lys 
    1145                 1150                 1155             


Val Val  Val Gly Glu Asp Glu  Phe Thr Lys Asp Thr  Glu Leu Gln 
    1160                 1165                 1170             


Glu Ile  Phe Pro Asn Asn Lys  Ser Ile Phe Phe Ala  Asn Leu Ala 
    1175                 1180                 1185             


Asn Val  Gln Glu Asn Asp Thr  Tyr Asn Gln Glu Lys  Lys Ser Leu 
    1190                 1195                 1200             


Glu Glu  Ile Glu Arg Lys Glu  Lys Leu Thr Gln Glu  Asn Val Ala 
    1205                 1210                 1215             


Leu Pro  Gln Ala His Thr Met  Ile Gly Thr Lys Asn  Phe Leu Lys 
    1220                 1225                 1230             


Asn Leu  Phe Leu Leu Ser Thr  Lys Gln Asn Val Ala  Gly Leu Glu 
    1235                 1240                 1245             


Glu Gln  Pro Tyr Thr Pro Ile  Leu Gln Asp Thr Arg  Ser Leu Asn 
    1250                 1255                 1260             


Asp Ser  Pro His Ser Glu Gly  Ile His Met Ala Asn  Phe Ser Lys 
    1265                 1270                 1275             


Ile Arg  Glu Glu Ala Asn Leu  Glu Gly Leu Gly Asn  Gln Thr Asn 
    1280                 1285                 1290             


Gln Met  Val Glu Arg Phe Pro  Ser Thr Thr Arg Met  Ser Ser Asn 
    1295                 1300                 1305             


Ala Ser  Gln His Val Ile Thr  Gln Arg Gly Lys Arg  Ser Leu Lys 
    1310                 1315                 1320             


Gln Pro  Arg Leu Ser Gln Gly  Glu Ile Lys Phe Glu  Arg Lys Val 
    1325                 1330                 1335             


Ile Ala  Asn Asp Thr Ser Thr  Gln Trp Ser Lys Asn  Met Asn Tyr 
    1340                 1345                 1350             


Leu Ala  Gln Gly Thr Leu Thr  Gln Ile Glu Tyr Asn  Glu Lys Glu 
    1355                 1360                 1365             


Lys Arg  Ala Ile Thr Gln Ser  Pro Leu Ser Asp Cys  Ser Met Arg 
    1370                 1375                 1380             


Asn His  Val Thr Ile Gln Met  Asn Asp Ser Ala Leu  Pro Val Ala 
    1385                 1390                 1395             


Lys Glu  Ser Ala Ser Pro Ser  Val Arg His Thr Asp  Leu Thr Lys 
    1400                 1405                 1410             


Ile Pro  Ser Gln His Asn Ser  Ser His Leu Pro Ala  Ser Ala Cys 
    1415                 1420                 1425             


Asn Tyr  Thr Phe Arg Glu Arg  Thr Ser Gly Val Gln  Glu Gly Ser 
    1430                 1435                 1440             


His Phe  Leu Gln Glu Ala Lys  Arg Asn Asn Leu Ser  Leu Ala Phe 
    1445                 1450                 1455             


Val Thr  Leu Gly Ile Thr Glu  Gly Gln Gly Lys Phe  Ser Ser Leu 
    1460                 1465                 1470             


Gly Lys  Ser Ala Thr Asn Gln  Pro Met Tyr Lys Lys  Leu Glu Asn 
    1475                 1480                 1485             


Thr Val  Leu Leu Gln Pro Gly  Leu Ser Glu Thr Ser  Asp Lys Val 
    1490                 1495                 1500             


Glu Leu  Leu Ser Gln Val His  Val Asp Gln Glu Asp  Ser Phe Pro 
    1505                 1510                 1515             


Thr Lys  Thr Ser Asn Asp Ser  Pro Gly His Leu Asp  Leu Met Gly 
    1520                 1525                 1530             


Lys Ile  Phe Leu Gln Lys Thr  Gln Gly Pro Val Lys  Met Asn Lys 
    1535                 1540                 1545             


Thr Asn  Ser Pro Gly Lys Val  Pro Phe Leu Lys Trp  Ala Thr Glu 
    1550                 1555                 1560             


Ser Ser  Glu Lys Ile Pro Ser  Lys Leu Leu Gly Val  Leu Ala Trp 
    1565                 1570                 1575             


Asp Asn  His Tyr Asp Thr Gln  Ile Pro Ser Glu Glu  Trp Lys Ser 
    1580                 1585                 1590             


Gln Lys  Lys Ser Gln Thr Asn  Thr Ala Phe Lys Arg  Lys Asp Thr 
    1595                 1600                 1605             


Ile Leu  Pro Leu Gly Pro Cys  Glu Asn Asn Asp Ser  Thr Ala Ala 
    1610                 1615                 1620             


Ile Asn  Glu Gly Gln Asp Lys  Pro Gln Arg Glu Ala  Met Trp Ala 
    1625                 1630                 1635             


Lys Gln  Gly Glu Pro Gly Arg  Leu Cys Ser Gln Asn  Pro Pro Val 
    1640                 1645                 1650             


Ser Lys  His His Gln Arg Glu  Ile Thr Val Thr Thr  Leu Gln Pro 
    1655                 1660                 1665             


Glu Glu  Asp Lys Phe Glu Tyr  Asp Asp Thr Phe Ser  Ile Glu Met 
    1670                 1675                 1680             


Lys Arg  Glu Asp Phe Asp Ile  Tyr Gly Asp Tyr Glu  Asp Gln Gly 
    1685                 1690                 1695             


Leu Arg  Ser Phe Gln Lys Lys  Thr Arg His Tyr Phe  Ile Ala Ala 
    1700                 1705                 1710             


Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser Arg Ser  Pro His Ile 
    1715                 1720                 1725             


Leu Arg  Asn Arg Ala Gln Ser  Gly Asp Val Gln Gln  Phe Lys Lys 
    1730                 1735                 1740             


Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser Phe Thr  Gln Pro Leu 
    1745                 1750                 1755             


Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr 
    1760                 1765                 1770             


Ile Arg  Ala Glu Val Glu Asp  Asn Ile Val Val Thr  Phe Lys Asn 
    1775                 1780                 1785             


Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr 
    1790                 1795                 1800             


Asp Glu  Asp Glu Gly Gln Gly  Ala Glu Pro Arg Arg  Lys Phe Val 
    1805                 1810                 1815             


Asn Pro  Asn Glu Thr Lys Ile  Tyr Phe Trp Lys Val  Gln His His 
    1820                 1825                 1830             


Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr 
    1835                 1840                 1845             


Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val His Ser  Gly Leu Ile 
    1850                 1855                 1860             


Gly Pro  Leu Leu Ile Cys Arg  Ser Asn Thr Leu Asn  Pro Ala His 
    1865                 1870                 1875             


Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala Leu Val  Phe Thr Ile 
    1880                 1885                 1890             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Leu Glu Arg 
    1895                 1900                 1905             


Asn Cys  Arg Ala Pro Cys Asn  Val Gln Lys Glu Asp  Pro Thr Leu 
    1910                 1915                 1920             


Lys Glu  Asn Phe Arg Phe His  Ala Ile Asn Gly Tyr  Val Lys Asp 
    1925                 1930                 1935             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp Gln Lys  Val Arg Trp 
    1940                 1945                 1950             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1955                 1960                 1965             


Phe Ser  Gly His Val Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1970                 1975                 1980             


Met Ala  Val Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    1985                 1990                 1995             


Met Leu  Pro Ser Gln Val Gly  Ile Trp Arg Ile Glu  Cys Leu Ile 
    2000                 2005                 2010             


Gly Glu  His Leu Gln Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr 
    2015                 2020                 2025             


Ser Lys  Lys Cys Gln Thr Pro  Leu Gly Met Ala Ser  Gly His Ile 
    2030                 2035                 2040             


Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala 
    2045                 2050                 2055             


Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp 
    2060                 2065                 2070             


Ser Thr  Lys Asp Pro Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    2075                 2080                 2085             


Pro Met  Ile Ile His Gly Ile  Met Thr Gln Gly Ala  Arg Gln Lys 
    2090                 2095                 2100             


Phe Ser  Ser Leu Tyr Val Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    2105                 2110                 2115             


Asp Gly  Asn Lys Trp His Ser  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    2120                 2125                 2130             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ser Ser Gly  Ile Lys His 
    2135                 2140                 2145             


Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Gln Tyr Ile  Arg Leu His 
    2150                 2155                 2160             


Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Leu 
    2165                 2170                 2175             


Gly Cys  Asp Phe Asn Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser 
    2180                 2185                 2190             


Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala Ser Ser  Tyr Leu Ser 
    2195                 2200                 2205             


Ser Met  Leu Ala Thr Trp Ser  Pro Ser Gln Ala Arg  Leu His Leu 
    2210                 2215                 2220             


Gln Gly  Arg Thr Asn Ala Trp  Arg Pro Gln Ala Asn  Asn Pro Lys 
    2225                 2230                 2235             


Glu Trp  Leu Gln Val Asp Phe  Arg Lys Thr Met Lys  Val Thr Gly 
    2240                 2245                 2250             


Ile Thr  Thr Gln Gly Val Lys  Ser Leu Leu Ile Ser  Met Tyr Val 
    2255                 2260                 2265             


Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp Gly His  Asn Trp Thr 
    2270                 2275                 2280             


Leu Phe  Leu Gln Asn Asp Lys  Val Lys Val Phe Gln  Gly Asn Arg 
    2285                 2290                 2295             


Asp Ser  Ser Thr Pro Val Arg  Asn Ala Leu Glu Pro  Pro Leu Val 
    2300                 2305                 2310             


Ala Arg  Tyr Val Arg Leu His  Pro Gln Ser Trp Ala  His His Ile 
    2315                 2320                 2325             


Ala Leu  Arg Leu Glu Val Leu  Gly Cys Asp Thr Gln  Gln Pro Ala 
    2330                 2335                 2340             


<210>  71
<211>  2323
<212>  PRT
<213>  Bos taurus

<400>  71

Met His Ile Lys Leu Ser Thr Cys Phe Phe Leu Cys Leu Trp Pro Cys 
1               5                   10                  15      


Ser Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asn Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Lys Pro Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Arg Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Phe Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Ile Gly Val Ser Tyr Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Ala Tyr Glu Asp Glu Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Lys Ser His Thr Tyr Val Trp Gln Ile 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Val Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Ile Cys Arg Glu Gly Thr Leu Ile Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Gly Lys Asn Glu Ser Leu Thr Arg Val Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Leu His Thr Ile Asn Gly Tyr Ile Asn Arg Ser 
                245                 250                 255     


Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser Val Tyr Trp His Val 
            260                 265                 270         


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
        275                 280                 285             


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
    290                 295                 300                 


Pro Ile Thr Phe Leu Thr Ala Gln Thr Val Leu Met Asp Cys Gly Gln 
305                 310                 315                 320 


Phe Leu Leu Phe Cys Arg Ile Ser Ser His Gln His Asp Gly Met Glu 
                325                 330                 335     


Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Arg Leu Trp Met 
            340                 345                 350         


Lys Asn Asn Gln Glu Glu Asp Tyr Asp Asp Gly Leu Asp Asp Ser Asp 
        355                 360                 365             


Met Asp Val Val Arg Phe Asp Gly Asp Ser Ala Pro Pro Phe Ile Gln 
    370                 375                 380                 


Met Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile 
385                 390                 395                 400 


Ala Ala Glu Glu Asp Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Thr 
                405                 410                 415     


Ser Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn His Gly Pro Gln Arg 
            420                 425                 430         


Ile Gly Arg Lys Tyr Arg Lys Val Arg Phe Ile Ala Tyr Thr Asp Gly 
        435                 440                 445             


Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly 
    450                 455                 460                 


Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys 
465                 470                 475                 480 


Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp 
                485                 490                 495     


Val Ser Pro Leu His Ser Gly Arg Phe Pro Lys Gly Val Lys His Leu 
            500                 505                 510         


Lys Asp Met Pro Ile Leu Pro Gly Glu Val Phe Lys Tyr Lys Trp Thr 
        515                 520                 525             


Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 
    530                 535                 540                 


Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu Lys Asp Leu Ala Ser Gly 
545                 550                 555                 560 


Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 
                565                 570                 575     


Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 
            580                 585                 590         


Phe Asp Glu Asn Lys Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 
        595                 600                 605             


Leu Pro Asn Gly Val Gln Pro Gln Asp Pro Glu Phe Gln Val Ser Asn 
    610                 615                 620                 


Val Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
625                 630                 635                 640 


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly Ala 
                645                 650                 655     


Gln Ile Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
            660                 665                 670         


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
        675                 680                 685             


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys 
    690                 695                 700                 


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
705                 710                 715                 720 


Asp Ser Cys Asp Arg Asn Val Gly Asp Tyr Tyr Asp Thr Tyr Glu Asp 
                725                 730                 735     


Ile Pro Thr Leu Leu Ser Asp Asp Asn Val Ile Glu Pro Arg Ser Phe 
            740                 745                 750         


Ser Lys Asn Ser Arg Tyr Pro Ser Thr Arg Gln Lys Gln Phe Lys Pro 
        755                 760                 765             


Thr Met Thr Pro Glu Asn Asp Met Glu Lys Ile Asp Pro Gln Ser Gly 
    770                 775                 780                 


Glu Lys Met Gln Leu Leu Thr Glu Gln Ser Val Ser Ser Ser Asp Leu 
785                 790                 795                 800 


Leu Met Leu Leu Gly Gln Asn Pro Thr Pro His Arg Leu Ser Leu Ser 
                805                 810                 815     


Asp Leu Gln Glu Thr Arg Asn Glu Ala Thr Asp His Leu Pro Gly Pro 
            820                 825                 830         


Thr Glu Arg Ile Lys Gly Pro Ser Pro Ser Glu Val Ala His Leu Arg 
        835                 840                 845             


Pro Glu Leu His His Ser Gly Glu Arg Val Phe Thr Gln Glu Pro Glu 
    850                 855                 860                 


Leu Pro Val Arg Leu Asn Glu Asn Leu Gly Thr Thr Ile Met Ala Glu 
865                 870                 875                 880 


Leu Asn Lys Leu Asn Leu Lys Ile Ser Ser Ser Ser Asn Asn Leu Met 
                885                 890                 895     


Pro Leu Pro Thr Ile Pro Ser Asp Lys Leu Ser Ala Gly Thr Lys Lys 
            900                 905                 910         


Thr Gly Ser Phe Gly Pro Pro Asn Met Pro Val Asn Phe Asn Ser Gln 
        915                 920                 925             


Leu Gly Ala Ile Val Phe Gly Lys Asn Leu Ser His Val Ile Gly Ser 
    930                 935                 940                 


Arg Val Pro Leu Gly Leu Ser Lys Glu Asp Asn Asn Ser Lys Leu Leu 
945                 950                 955                 960 


Glu Ala Ala Leu Met Asn Ser Gln Glu Ser Ser Leu Gly Glu Asn Ala 
                965                 970                 975     


Leu Ser Leu Glu Ser Asp Arg Leu Phe Lys Glu Glu Arg Val His Gly 
            980                 985                 990         


Pro Val Ser Leu Asn Lys Asp Asp  Ala Leu Phe Lys Val  Asn Ile Ser 
        995                 1000                 1005             


Leu Val  Lys Thr Asp Lys Ala  Pro Ala Asn Ser Thr  Thr Asn Arg 
    1010                 1015                 1020             


Lys Thr  His Ile Asp Asp Pro  Thr Val Leu Ile Glu  Asn Ser Thr 
    1025                 1030                 1035             


Ser Val  Trp Gln Asp Ile Val  Ile Asp Ser Asn Thr  Asn Phe Gln 
    1040                 1045                 1050             


Glu Val  Thr Ser Leu Ile His  Asp Glu Leu Phe Met  His Lys Asn 
    1055                 1060                 1065             


Thr Thr  Ser Phe Gly Leu Ser  His Met Ser Asn Lys  Thr Thr Ser 
    1070                 1075                 1080             


Ser Lys  Lys Arg Glu Met Ile  His Gln Glu Lys Glu  Gly Pro Lys 
    1085                 1090                 1095             


Pro Leu  Asp Thr Lys Tyr Pro  Asp Thr Pro Phe Phe  Lys Thr Leu 
    1100                 1105                 1110             


Phe Leu  Pro Asp Ser Thr Asn  Val Ile Lys Arg Thr  His Asp Lys 
    1115                 1120                 1125             


Asn Ser  Leu Ser Ser Gly Gln  Arg Pro Ser Pro Lys  Gln Leu Thr 
    1130                 1135                 1140             


Ser Ser  Val Ser Glu Asn Ser  Val Lys Asp Gln Asn  Val Leu Ser 
    1145                 1150                 1155             


Glu Lys  Asn Lys Ala Val Ala  Gly Glu Asp Glu Phe  Ser Asn Asn 
    1160                 1165                 1170             


Thr Ser  Leu Lys Glu Met Ile  Phe Pro Asn Thr Lys  Ser Ile Val 
    1175                 1180                 1185             


Leu Thr  Asn Leu Ala Asn Val  Gln Glu Asn Asp Thr  Asp Asn Gln 
    1190                 1195                 1200             


Gly Lys  Lys Ser Gln Glu Glu  Thr Glu Lys Lys Glu  Thr Leu Ile 
    1205                 1210                 1215             


Pro Glu  Asn Thr Val Leu Pro  Gln Val Tyr Thr Val  Ile Gly Thr 
    1220                 1225                 1230             


Lys Asn  Phe Leu Lys Asn Leu  Phe Ser Leu Ser Thr  Lys Gln Asn 
    1235                 1240                 1245             


Val Arg  Gly Leu Asp Glu Glu  Thr Tyr Thr Pro Gly  Leu Gln Asp 
    1250                 1255                 1260             


Asn Arg  Ser Leu Ser Asp Ser  Ala Lys Arg Ala Arg  Ile His Ala 
    1265                 1270                 1275             


Ala His  Phe Ser Lys Gly Arg  Val Glu Ala Asn Val  Glu Gly Leu 
    1280                 1285                 1290             


Gly Asn  Gln Thr Lys Gln Met  Val Glu Lys Ser Pro  Ser Thr Thr 
    1295                 1300                 1305             


Lys Leu  Ser Pro Ile Pro Ser  Gln Gln Asp Ala Val  Pro His Arg 
    1310                 1315                 1320             


Asp Lys  Arg Gly Leu Lys Gln  Ser Arg Leu Pro Arg  Glu Glu Val 
    1325                 1330                 1335             


Lys Leu  Glu Arg Gly Val Thr  Leu Asn Asp Thr Ser  Thr Gln Trp 
    1340                 1345                 1350             


Ser Lys  Ser Met Lys His Leu  Thr Gln Gly Thr Phe  Thr Gln Ile 
    1355                 1360                 1365             


Glu His  Asn Lys Met Glu Lys  Arg Thr Ile Thr Gln  Ser Phe Leu 
    1370                 1375                 1380             


Pro Asp  Cys Ser Leu Arg Ser  His Arg Ser Ile Arg  Pro Thr Asp 
    1385                 1390                 1395             


Val Thr  Lys Ile Pro Pro Gln  His Asn Ser Ser His  Pro Pro Ala 
    1400                 1405                 1410             


Ser Thr  Tyr Gly Tyr Asn Leu  Gly Ala Ser His Ser  Gly Val Gln 
    1415                 1420                 1425             


Glu Thr  Ser His Phe Leu His  Gly Ala Lys Lys Asn  Asn Leu Ser 
    1430                 1435                 1440             


Leu Ala  Phe Leu Thr Leu Glu  Val Ile Gly Ser Gln  Arg Lys Ser 
    1445                 1450                 1455             


Ser Thr  Pro Gly Lys Gln Ala  Thr Asn Pro Leu Met  Tyr Lys Lys 
    1460                 1465                 1470             


Leu Glu  Asn Met Phe Leu Leu  Lys Pro Gly Leu Ser  Glu Ala Ser 
    1475                 1480                 1485             


Gly Lys  Val Val His Gln Glu  Asp Leu Pro Thr Lys  Thr Ser Lys 
    1490                 1495                 1500             


Val Ser  Pro Ala His Leu Asp  Leu Arg Glu Glu Ile  Phe Leu Gln 
    1505                 1510                 1515             


Lys Thr  Gln Gly Leu Val Lys  Leu Asn Lys Val Tyr  Arg Thr Gly 
    1520                 1525                 1530             


Lys Val  Pro Ser Leu Lys Trp  Thr Thr Glu Ser Ser  Glu Glu Ile 
    1535                 1540                 1545             


Pro Ser  Lys Leu Leu Gly Leu  Leu Ala Trp Asp Asn  Gln Ser Ala 
    1550                 1555                 1560             


Thr Leu  Ile Pro Lys Glu Asp  Trp Lys Ser Leu Glu  Arg Ser His 
    1565                 1570                 1575             


Lys Leu  Thr Ser Leu Lys Thr  Lys Asp Ile Thr Leu  Pro Leu Asp 
    1580                 1585                 1590             


Pro Ser  Glu Asn Tyr Tyr Ser  Ile Ala Val Thr Asn  Glu Gly Glu 
    1595                 1600                 1605             


Asp Lys  Ala Gln Arg Glu Ala  Pro Trp Pro Lys Gln  Gly Gly Thr 
    1610                 1615                 1620             


Gly Arg  Val Cys Cys Gln Asn  Pro Pro Ile Leu Lys  Arg His Gln 
    1625                 1630                 1635             


Arg Glu  Ile Thr Leu Thr Thr  Phe Gln Pro Glu Pro  Asp Lys Thr 
    1640                 1645                 1650             


Asp Tyr  Asp Asp Thr Leu Ser  Ile Glu Thr Lys Arg  Glu Asp Phe 
    1655                 1660                 1665             


Asp Ile  Tyr Gly Glu Asp Glu  Asn Gln Asp Pro Arg  Ser Phe Gln 
    1670                 1675                 1680             


Lys Arg  Thr Arg His Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp 
    1685                 1690                 1695             


Asp Tyr  Gly Met Ser Arg Ser  Pro Tyr Ala Leu Arg  Asn Arg Ser 
    1700                 1705                 1710             


Gln Asn  Gly Gly Val Pro Gln  Phe Lys Lys Val Val  Phe Glu Glu 
    1715                 1720                 1725             


Phe Thr  Asp Gly Ser Phe Thr  Gln Ala Ile Tyr Arg  Gly Gln Leu 
    1730                 1735                 1740             


Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val 
    1745                 1750                 1755             


Glu Asp  Asn Ile Met Val Thr  Phe Lys Asn Gln Ala  Ser Arg Pro 
    1760                 1765                 1770             


Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr Asn Gly  Asp Gln Arg 
    1775                 1780                 1785             


Gln Gly  Ala Glu Pro Arg Lys  Lys Phe Val Lys Pro  Asn Glu Thr 
    1790                 1795                 1800             


Gln Ser  Tyr Phe Trp Lys Val  Gln His His Met Ala  Pro Thr Lys 
    1805                 1810                 1815             


Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp 
    1820                 1825                 1830             


Leu Glu  Lys Asp Leu His Ser  Gly Leu Ile Gly Pro  Ile Leu Ile 
    1835                 1840                 1845             


Cys Arg  Val Asp Thr Leu Ser  Ala Ala His Gly Arg  Gln Val Thr 
    1850                 1855                 1860             


Ile Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1865                 1870                 1875             


Ser Trp  Tyr Phe Ala Glu Asn  Met Ala Arg Asn Cys  Gly Ala Pro 
    1880                 1885                 1890             


Cys His  Val Gln Pro Glu Asp  Pro Thr Phe Gln Glu  Lys Tyr Arg 
    1895                 1900                 1905             


Phe His  Ala Ile Asn Gly Tyr  Val Met Asp Thr Leu  Pro Gly Leu 
    1910                 1915                 1920             


Val Met  Ala Gln His Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1925                 1930                 1935             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1940                 1945                 1950             


Phe Thr  Val Arg Lys Thr Glu  Glu Tyr Lys Met Ala  Val Tyr Asn 
    1955                 1960                 1965             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1970                 1975                 1980             


Val Gly  Thr Trp Arg Ile Glu  Cys Leu Ile Gly Glu  His Leu Gln 
    1985                 1990                 1995             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Lys  Glu Cys Gln 
    2000                 2005                 2010             


Ile Pro  Leu Gly Met Ala Ser  Gly Arg Ile Arg Asp  Phe Gln Ile 
    2015                 2020                 2025             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    2030                 2035                 2040             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Asp Pro 
    2045                 2050                 2055             


Ser Pro  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    2060                 2065                 2070             


Ser Ile  Leu Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    2075                 2080                 2085             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Gln Arg Trp 
    2090                 2095                 2100             


Gln Gly  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    2105                 2110                 2115             


Gly Asn  Val Asp Ser Ser Gly  Val Lys His Asn Ile  Phe Asn Pro 
    2120                 2125                 2130             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    2135                 2140                 2145             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    2150                 2155                 2160             


Ser Cys  Asn Met Pro Leu Gly  Met Glu Asn Lys Ala  Ile Ser Asp 
    2165                 2170                 2175             


Thr Gln  Ile Thr Ala Ser Ser  His Leu Arg Asn Met  Phe Ala Thr 
    2180                 2185                 2190             


Trp Ser  Pro Ser Gln Ala Arg  Leu Asn Leu Gln Gly  Arg Thr Asn 
    2195                 2200                 2205             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    2210                 2215                 2220             


Asp Phe  Gln Lys Thr Met Arg  Val Thr Gly Ile Thr  Thr Gln Gly 
    2225                 2230                 2235             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    2240                 2245                 2250             


Ser Ser  Ser Gln Asp Gly His  Asn Trp Thr Pro Phe  Leu Gln Asn 
    2255                 2260                 2265             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    2270                 2275                 2280             


Val Val  Asn Ala Leu Asp Pro  Pro Leu Phe Thr Arg  Phe Leu Arg 
    2285                 2290                 2295             


Ile His  Pro Arg Ser Trp Ala  His His Ile Ala Leu  Arg Leu Glu 
    2300                 2305                 2310             


Leu Leu  Gly Cys Glu Ala Gln  Gln Gln Tyr 
    2315                 2320             


<210>  72
<211>  2323
<212>  PRT
<213>  Bos taurus

<400>  72

Met His Ile Lys Leu Ser Thr Cys Phe Phe Leu Cys Leu Trp Pro Cys 
1               5                   10                  15      


Ser Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asn Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Lys Pro Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Arg Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Phe Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Ile Gly Val Ser Tyr Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Ala Tyr Glu Asp Glu Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Lys Ser His Thr Tyr Val Trp Gln Ile 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Val Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Ile Cys Arg Glu Gly Thr Leu Ile Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Gly Lys Asn Glu Ser Leu Thr Arg Val Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Leu His Thr Ile Asn Gly Tyr Ile Asn Arg Ser 
                245                 250                 255     


Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser Val Tyr Trp His Val 
            260                 265                 270         


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
        275                 280                 285             


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
    290                 295                 300                 


Pro Ile Thr Phe Leu Thr Ala Gln Thr Val Leu Met Asp Cys Gly Gln 
305                 310                 315                 320 


Phe Leu Leu Phe Cys Arg Ile Ser Ser His Gln His Asp Gly Met Glu 
                325                 330                 335     


Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Arg Leu Trp Met 
            340                 345                 350         


Lys Asn Asn Gln Glu Glu Asp Tyr Asp Asp Gly Leu Asp Asp Ser Asp 
        355                 360                 365             


Met Asp Val Val Arg Phe Asp Gly Asp Ser Ala Pro Pro Phe Ile Gln 
    370                 375                 380                 


Met Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile 
385                 390                 395                 400 


Ala Ala Glu Glu Asp Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Thr 
                405                 410                 415     


Ser Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn His Gly Pro Gln Arg 
            420                 425                 430         


Ile Gly Arg Lys Tyr Arg Lys Val Arg Phe Ile Ala Tyr Thr Asp Gly 
        435                 440                 445             


Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly 
    450                 455                 460                 


Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys 
465                 470                 475                 480 


Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp 
                485                 490                 495     


Val Ser Pro Leu His Ser Gly Arg Phe Pro Lys Gly Val Lys His Leu 
            500                 505                 510         


Lys Asp Met Pro Ile Leu Pro Gly Glu Val Phe Lys Tyr Lys Trp Thr 
        515                 520                 525             


Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 
    530                 535                 540                 


Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu Lys Asp Leu Ala Ser Gly 
545                 550                 555                 560 


Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 
                565                 570                 575     


Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 
            580                 585                 590         


Phe Asp Glu Asn Lys Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 
        595                 600                 605             


Leu Pro Asn Gly Val Gln Pro Gln Asp Pro Glu Phe Gln Val Ser Asn 
    610                 615                 620                 


Val Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
625                 630                 635                 640 


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly Ala 
                645                 650                 655     


Gln Ile Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
            660                 665                 670         


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
        675                 680                 685             


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys 
    690                 695                 700                 


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
705                 710                 715                 720 


Asp Ser Cys Asp Arg Asn Val Gly Asp Tyr Tyr Asp Thr Tyr Glu Asp 
                725                 730                 735     


Ile Pro Thr Leu Leu Ser Asp Asp Asn Val Ile Glu Pro Arg Ser Phe 
            740                 745                 750         


Ser Lys Asn Ser Arg Tyr Pro Ser Thr Arg Gln Lys Gln Phe Lys Pro 
        755                 760                 765             


Thr Met Thr Pro Glu Asn Asp Met Glu Lys Ile Asp Pro Gln Ser Gly 
    770                 775                 780                 


Glu Lys Met Gln Leu Leu Thr Glu Gln Ser Val Ser Ser Ser Asp Leu 
785                 790                 795                 800 


Leu Met Leu Leu Gly Gln Asn Pro Thr Pro His Arg Leu Ser Leu Ser 
                805                 810                 815     


Asp Leu Gln Glu Thr Arg Asn Glu Ala Thr Asp His Leu Pro Gly Pro 
            820                 825                 830         


Thr Glu Arg Ile Lys Gly Pro Ser Pro Ser Glu Val Ala His Leu Arg 
        835                 840                 845             


Pro Glu Leu His His Ser Gly Glu Arg Val Phe Thr Gln Glu Pro Glu 
    850                 855                 860                 


Leu Pro Val Arg Leu Asn Glu Asn Leu Gly Thr Thr Ile Met Ala Glu 
865                 870                 875                 880 


Leu Asn Lys Leu Asn Leu Lys Ile Ser Ser Ser Ser Asn Asn Leu Met 
                885                 890                 895     


Pro Leu Pro Thr Ile Pro Ser Asp Lys Leu Ser Ala Gly Thr Lys Lys 
            900                 905                 910         


Thr Gly Ser Phe Gly Pro Pro Asn Met Pro Val Asn Phe Asn Ser Gln 
        915                 920                 925             


Leu Gly Ala Ile Val Phe Gly Lys Asn Leu Ser His Val Ile Gly Ser 
    930                 935                 940                 


Arg Val Pro Leu Gly Leu Ser Lys Glu Asp Asn Asn Ser Lys Leu Leu 
945                 950                 955                 960 


Glu Ala Ala Leu Met Asn Ser Gln Glu Ser Ser Leu Gly Glu Asn Ala 
                965                 970                 975     


Leu Ser Leu Glu Ser Asp Arg Leu Phe Lys Glu Glu Arg Val His Gly 
            980                 985                 990         


Pro Val Ser Leu Asn Lys Asp Asp  Ala Leu Phe Lys Val  Asn Ile Ser 
        995                 1000                 1005             


Leu Val  Lys Thr Asp Lys Ala  Pro Ala Asn Ser Thr  Thr Asn Arg 
    1010                 1015                 1020             


Lys Thr  His Ile Asp Asp Pro  Thr Val Leu Ile Glu  Asn Ser Thr 
    1025                 1030                 1035             


Ser Val  Trp Gln Asp Ile Val  Ile Asp Ser Asn Thr  Asn Phe Gln 
    1040                 1045                 1050             


Glu Val  Thr Ser Leu Ile His  Asp Glu Leu Phe Met  His Lys Asn 
    1055                 1060                 1065             


Thr Thr  Ser Phe Gly Leu Ser  His Met Ser Asn Lys  Thr Thr Ser 
    1070                 1075                 1080             


Ser Lys  Lys Arg Glu Met Ile  His Gln Glu Lys Glu  Gly Pro Lys 
    1085                 1090                 1095             


Pro Leu  Asp Thr Lys Tyr Pro  Asp Thr Pro Phe Phe  Lys Thr Leu 
    1100                 1105                 1110             


Phe Leu  Pro Asp Ser Thr Asn  Val Ile Lys Arg Thr  His Asp Lys 
    1115                 1120                 1125             


Asn Ser  Leu Ser Ser Gly Gln  Arg Pro Ser Pro Lys  Gln Leu Thr 
    1130                 1135                 1140             


Ser Ser  Val Ser Glu Asn Ser  Val Lys Asp Gln Asn  Val Leu Ser 
    1145                 1150                 1155             


Glu Lys  Asn Lys Ala Val Ala  Gly Glu Asp Glu Phe  Ser Asn Asn 
    1160                 1165                 1170             


Thr Ser  Leu Lys Glu Met Ile  Phe Pro Asn Thr Lys  Ser Ile Val 
    1175                 1180                 1185             


Leu Thr  Asn Leu Ala Asn Val  Gln Glu Asn Asp Thr  Asp Asn Gln 
    1190                 1195                 1200             


Gly Lys  Lys Ser Gln Glu Glu  Thr Glu Lys Lys Glu  Thr Leu Ile 
    1205                 1210                 1215             


Pro Glu  Asn Thr Val Leu Pro  Gln Val Tyr Thr Val  Ile Gly Thr 
    1220                 1225                 1230             


Lys Asn  Phe Leu Lys Asn Leu  Phe Ser Leu Ser Thr  Lys Gln Asn 
    1235                 1240                 1245             


Val Arg  Gly Leu Asp Glu Glu  Thr Tyr Thr Pro Gly  Leu Gln Asp 
    1250                 1255                 1260             


Asn Arg  Ser Leu Ser Asp Ser  Ala Lys Arg Ala Arg  Ile His Ala 
    1265                 1270                 1275             


Ala His  Phe Ser Lys Gly Arg  Val Glu Ala Asn Val  Glu Gly Leu 
    1280                 1285                 1290             


Gly Asn  Gln Thr Lys Gln Met  Val Glu Lys Ser Pro  Ser Thr Thr 
    1295                 1300                 1305             


Lys Leu  Ser Pro Ile Pro Ser  Gln Gln Asp Ala Val  Pro His Arg 
    1310                 1315                 1320             


Asp Lys  Arg Gly Leu Lys Gln  Ser Arg Leu Pro Arg  Glu Glu Val 
    1325                 1330                 1335             


Lys Leu  Glu Arg Gly Val Thr  Leu Asn Asp Thr Ser  Thr Gln Trp 
    1340                 1345                 1350             


Ser Lys  Ser Met Lys His Leu  Thr Gln Gly Thr Phe  Thr Gln Ile 
    1355                 1360                 1365             


Glu His  Asn Lys Met Glu Lys  Arg Thr Ile Thr Gln  Ser Phe Leu 
    1370                 1375                 1380             


Pro Asp  Cys Ser Leu Arg Ser  His Arg Ser Ile Arg  Pro Thr Asp 
    1385                 1390                 1395             


Val Thr  Lys Ile Pro Pro Gln  His Asn Ser Ser His  Pro Pro Ala 
    1400                 1405                 1410             


Ser Thr  Tyr Gly Tyr Asn Leu  Gly Ala Ser His Ser  Gly Val Gln 
    1415                 1420                 1425             


Glu Thr  Ser His Phe Leu His  Gly Ala Lys Lys Asn  Asn Leu Ser 
    1430                 1435                 1440             


Leu Ala  Phe Leu Thr Leu Glu  Val Ile Gly Ser Gln  Arg Lys Ser 
    1445                 1450                 1455             


Ser Thr  Ser Gly Lys Gln Ala  Thr Asn Pro Leu Met  Tyr Lys Lys 
    1460                 1465                 1470             


Leu Glu  Asn Met Phe Leu Leu  Lys Pro Gly Leu Ser  Glu Ala Ser 
    1475                 1480                 1485             


Gly Lys  Val Val His Gln Gly  Asp Leu Pro Thr Lys  Thr Ser Lys 
    1490                 1495                 1500             


Val Ser  Pro Ala His Leu Asp  Leu Arg Glu Glu Ile  Phe Leu Gln 
    1505                 1510                 1515             


Lys Thr  Gln Gly Leu Val Lys  Leu Asn Lys Val Tyr  Arg Thr Gly 
    1520                 1525                 1530             


Lys Val  Pro Ser Leu Lys Trp  Thr Thr Glu Ser Ser  Glu Glu Ile 
    1535                 1540                 1545             


Pro Ser  Lys Leu Leu Gly Leu  Leu Ala Trp Asp Asn  Gln Ser Ala 
    1550                 1555                 1560             


Thr Leu  Ile Pro Lys Glu Asp  Trp Lys Ser Leu Glu  Arg Ser His 
    1565                 1570                 1575             


Lys Leu  Thr Ser Leu Lys Thr  Lys Asp Ile Thr Leu  Pro Leu Asp 
    1580                 1585                 1590             


Pro Ser  Glu Asn Tyr Tyr Ser  Ile Ala Val Thr Asn  Glu Gly Glu 
    1595                 1600                 1605             


Asp Lys  Ala Gln Arg Glu Ala  Pro Trp Pro Lys Gln  Gly Gly Thr 
    1610                 1615                 1620             


Gly Arg  Val Cys Cys Gln Asn  Pro Pro Ile Leu Lys  Arg His Gln 
    1625                 1630                 1635             


Arg Glu  Ile Thr Leu Thr Thr  Phe Gln Pro Glu Pro  Asp Lys Thr 
    1640                 1645                 1650             


Asp Tyr  Asp Asp Thr Leu Ser  Ile Glu Thr Lys Arg  Glu Asp Phe 
    1655                 1660                 1665             


Asp Ile  Tyr Gly Glu Asp Glu  Asn Gln Asp Pro Arg  Ser Phe Gln 
    1670                 1675                 1680             


Lys Arg  Thr Arg His Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp 
    1685                 1690                 1695             


Asp Tyr  Gly Met Ser Arg Ser  Pro Tyr Ala Leu Arg  Asn Arg Ser 
    1700                 1705                 1710             


Gln Asn  Gly Gly Val Pro Gln  Phe Lys Lys Val Val  Phe Glu Glu 
    1715                 1720                 1725             


Phe Thr  Asp Gly Ser Phe Thr  Gln Ala Ile Tyr Arg  Gly Gln Leu 
    1730                 1735                 1740             


Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val 
    1745                 1750                 1755             


Glu Asp  Asn Ile Met Val Thr  Phe Lys Asn Gln Ala  Ser Arg Pro 
    1760                 1765                 1770             


Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr Asn Gly  Asp Gln Arg 
    1775                 1780                 1785             


Gln Gly  Ala Glu Pro Arg Lys  Lys Phe Val Lys Pro  Asn Glu Thr 
    1790                 1795                 1800             


Gln Ser  Tyr Phe Trp Lys Val  Gln His His Met Ala  Pro Thr Lys 
    1805                 1810                 1815             


Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp 
    1820                 1825                 1830             


Leu Glu  Lys Asp Leu His Ser  Gly Leu Ile Gly Pro  Ile Leu Ile 
    1835                 1840                 1845             


Cys Arg  Val Asp Thr Leu Ser  Ala Ala His Gly Arg  Gln Val Thr 
    1850                 1855                 1860             


Ile Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1865                 1870                 1875             


Ser Trp  Tyr Phe Ala Glu Asn  Met Ala Arg Asn Cys  Gly Ala Pro 
    1880                 1885                 1890             


Cys His  Val Gln Pro Glu Asp  Pro Thr Phe Gln Glu  Lys Tyr Arg 
    1895                 1900                 1905             


Phe His  Ala Ile Asn Gly Tyr  Val Met Asp Thr Leu  Pro Gly Leu 
    1910                 1915                 1920             


Val Met  Ala Gln His Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1925                 1930                 1935             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1940                 1945                 1950             


Phe Thr  Val Arg Lys Thr Glu  Glu Tyr Lys Met Ala  Val Tyr Asn 
    1955                 1960                 1965             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1970                 1975                 1980             


Val Gly  Thr Trp Arg Ile Glu  Cys Leu Ile Gly Glu  His Leu Gln 
    1985                 1990                 1995             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Lys  Glu Cys Gln 
    2000                 2005                 2010             


Ile Pro  Leu Gly Met Ala Ser  Gly Arg Ile Arg Asp  Phe Gln Ile 
    2015                 2020                 2025             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    2030                 2035                 2040             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Asp Pro 
    2045                 2050                 2055             


Ser Pro  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    2060                 2065                 2070             


Ser Ile  Leu Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    2075                 2080                 2085             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Gln Arg Trp 
    2090                 2095                 2100             


Gln Gly  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    2105                 2110                 2115             


Gly Asn  Val Asp Ser Ser Gly  Val Lys His Asn Ile  Phe Asn Pro 
    2120                 2125                 2130             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    2135                 2140                 2145             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    2150                 2155                 2160             


Ser Cys  Asn Met Pro Leu Gly  Met Glu Asn Lys Ala  Ile Ser Asp 
    2165                 2170                 2175             


Thr Gln  Ile Thr Ala Ser Ser  His Leu Arg Asn Met  Phe Ala Thr 
    2180                 2185                 2190             


Trp Ser  Pro Ser Gln Ala Arg  Leu Asn Leu Gln Gly  Arg Thr Asn 
    2195                 2200                 2205             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    2210                 2215                 2220             


Asp Phe  Gln Lys Thr Met Arg  Val Thr Gly Ile Thr  Thr Gln Gly 
    2225                 2230                 2235             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    2240                 2245                 2250             


Ser Ser  Ser Gln Asp Gly His  Asn Trp Thr Pro Phe  Leu Gln Asn 
    2255                 2260                 2265             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    2270                 2275                 2280             


Val Val  Asn Ala Leu Asp Pro  Pro Leu Phe Thr Arg  Phe Leu Arg 
    2285                 2290                 2295             


Ile His  Pro Arg Ser Trp Ala  His His Ile Ala Leu  Arg Leu Glu 
    2300                 2305                 2310             


Leu Leu  Gly Cys Glu Ala Gln  Gln Gln Tyr 
    2315                 2320             


<210>  73
<211>  2249
<212>  PRT
<213>  Mus musculus

<400>  73

Met Gln Ile Ala Leu Phe Ala Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Ile Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Ser 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Ser Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Lys Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Asp Glu Tyr Glu Asp Gln Thr Ser Gln Met Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Met Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu Tyr Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Asp Ser Tyr Thr Gln Ser Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Asp Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Ile His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Phe Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Ser Gln Trp Gln Lys Lys Asn Asn Asn Glu Glu Met Glu Asp Tyr Asp 
        355                 360                 365             


Asp Asp Leu Tyr Ser Glu Met Asp Met Phe Thr Leu Asp Tyr Asp Ser 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr 
385                 390                 395                 400 


Trp Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ser Val Pro Thr Ser Asp Asn Gly Ser Tyr Lys Ser Gln Tyr Leu Ser 
            420                 425                 430         


Asn Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Ser Pro Leu His Ala Arg Arg Leu Pro Arg 
            500                 505                 510         


Gly Ile Lys His Val Lys Asp Leu Pro Ile His Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Ile Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu 
        595                 600                 605             


Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Lys Thr Gln Pro Gln Asp 
    610                 615                 620                 


Pro Gly Phe Gln Ala Ser Asn Ile Met His Ser Leu Trp Val Leu Gly 
625                 630                 635                 640 


Cys His Asn Ser Asp Phe Arg Lys Arg Gly Met Thr Ala Leu Leu Lys 
                645                 650                 655     


Val Ser Ser Cys Asp Lys Ser Thr Ser Asp Tyr Tyr Glu Glu Ile Tyr 
            660                 665                 670         


Glu Asp Ile Pro Thr Gln Leu Val Asn Glu Asn Asn Val Ile Asp Pro 
        675                 680                 685             


Arg Ser Phe Phe Gln Asn Thr Asn His Pro Asn Thr Arg Lys Lys Lys 
    690                 695                 700                 


Phe Lys Asp Ser Thr Ile Pro Lys Asn Asp Met Glu Lys Ile Glu Pro 
705                 710                 715                 720 


Gln Phe Glu Glu Ile Ala Glu Met Leu Lys Val Gln Ser Val Ser Val 
                725                 730                 735     


Ser Asp Met Leu Met Leu Leu Gly Gln Ser His Pro Thr Pro His Gly 
            740                 745                 750         


Leu Phe Leu Ser Asp Gly Gln Glu Ala Ile Tyr Glu Ala Ile His Asp 
        755                 760                 765             


Asp His Ser Pro Asn Ala Ile Asp Ser Asn Glu Gly Pro Ser Lys Val 
    770                 775                 780                 


Thr Gln Leu Arg Pro Glu Ser His His Ser Glu Lys Ile Val Phe Thr 
785                 790                 795                 800 


Pro Gln Pro Gly Leu Gln Leu Arg Ser Asn Lys Ser Leu Glu Thr Thr 
                805                 810                 815     


Ile Glu Val Lys Trp Lys Lys Leu Gly Leu Gln Val Ser Ser Leu Pro 
            820                 825                 830         


Ser Asn Leu Met Thr Thr Thr Ile Leu Ser Asp Asn Leu Lys Ala Thr 
        835                 840                 845             


Phe Glu Lys Thr Asp Ser Ser Gly Phe Pro Asp Met Pro Val His Ser 
    850                 855                 860                 


Ser Ser Lys Leu Ser Thr Thr Ala Phe Gly Lys Lys Ala Tyr Ser Leu 
865                 870                 875                 880 


Val Gly Ser His Val Pro Leu Asn Val Ser Glu Glu Asn Ser Asp Ser 
                885                 890                 895     


Asn Ile Leu Asp Ser Thr Leu Met Tyr Ser Gln Glu Ser Leu Pro Arg 
            900                 905                 910         


Asp Asn Ile Leu Ser Met Glu Asn Asp Arg Leu Leu Arg Glu Lys Arg 
        915                 920                 925             


Phe His Gly Ile Ala Leu Leu Thr Lys Asp Asn Thr Leu Phe Lys Asp 
    930                 935                 940                 


Asn Val Ser Leu Met Lys Thr Asn Lys Thr Tyr Asn His Ser Thr Thr 
945                 950                 955                 960 


Asn Glu Lys Leu His Thr Glu Ser Pro Thr Ser Ile Glu Asn Ser Thr 
                965                 970                 975     


Thr Asp Leu Gln Asp Ala Ile Leu Lys Val Asn Ser Glu Ile Gln Glu 
            980                 985                 990         


Val Thr Ala Leu Ile His Asp Gly  Thr Leu Leu Gly Lys  Asn Ser Thr 
        995                 1000                 1005             


Tyr Leu  Arg Leu Asn His Met  Leu Asn Arg Thr Thr  Ser Thr Lys 
    1010                 1015                 1020             


Asn Lys  Asp Ile Phe His Arg  Lys Asp Glu Asp Pro  Ile Pro Gln 
    1025                 1030                 1035             


Asp Glu  Glu Asn Thr Ile Met  Pro Phe Ser Lys Met  Leu Phe Leu 
    1040                 1045                 1050             


Ser Glu  Ser Ser Asn Trp Phe  Lys Lys Thr Asn Gly  Asn Asn Ser 
    1055                 1060                 1065             


Leu Asn  Ser Glu Gln Glu His  Ser Pro Lys Gln Leu  Val Tyr Leu 
    1070                 1075                 1080             


Met Phe  Lys Lys Tyr Val Lys  Asn Gln Ser Phe Leu  Ser Glu Lys 
    1085                 1090                 1095             


Asn Lys  Val Thr Val Glu Gln  Asp Gly Phe Thr Lys  Asn Ile Gly 
    1100                 1105                 1110             


Leu Lys  Asp Met Ala Phe Pro  His Asn Met Ser Ile  Phe Leu Thr 
    1115                 1120                 1125             


Thr Leu  Ser Asn Val His Glu  Asn Gly Arg His Asn  Gln Glu Lys 
    1130                 1135                 1140             


Asn Ile  Gln Glu Glu Ile Glu  Lys Glu Ala Leu Ile  Glu Glu Lys 
    1145                 1150                 1155             


Val Val  Leu Pro Gln Val His  Glu Ala Thr Gly Ser  Lys Asn Phe 
    1160                 1165                 1170             


Leu Lys  Asp Ile Leu Ile Leu  Gly Thr Arg Gln Asn  Ile Ser Leu 
    1175                 1180                 1185             


Tyr Glu  Val His Val Pro Val  Leu Gln Asn Ile Thr  Ser Ile Asn 
    1190                 1195                 1200             


Asn Ser  Thr Asn Thr Val Gln  Ile His Met Glu His  Phe Phe Lys 
    1205                 1210                 1215             


Arg Arg  Lys Asp Lys Glu Thr  Asn Ser Glu Gly Leu  Val Asn Lys 
    1220                 1225                 1230             


Thr Arg  Glu Met Val Lys Asn  Tyr Pro Ser Gln Lys  Asn Ile Thr 
    1235                 1240                 1245             


Thr Gln  Arg Ser Lys Arg Ala  Leu Gly Gln Phe Arg  Leu Ser Thr 
    1250                 1255                 1260             


Gln Trp  Leu Lys Thr Ile Asn  Cys Ser Thr Gln Cys  Ile Ile Lys 
    1265                 1270                 1275             


Gln Ile  Asp His Ser Lys Glu  Met Lys Lys Phe Ile  Thr Lys Ser 
    1280                 1285                 1290             


Ser Leu  Ser Asp Ser Ser Val  Ile Lys Ser Thr Thr  Gln Thr Asn 
    1295                 1300                 1305             


Ser Ser  Asp Ser His Ile Val  Lys Thr Ser Ala Phe  Pro Pro Ile 
    1310                 1315                 1320             


Asp Leu  Lys Arg Ser Pro Phe  Gln Asn Lys Phe Ser  His Val Gln 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Ile Tyr Asp  Phe Lys Thr Lys Ser  Ser Arg Ile 
    1340                 1345                 1350             


Gln Glu  Ser Asn Asn Phe Leu  Lys Glu Thr Lys Ile  Asn Asn Pro 
    1355                 1360                 1365             


Ser Leu  Ala Ile Leu Pro Trp  Asn Met Phe Ile Asp  Gln Gly Lys 
    1370                 1375                 1380             


Phe Thr  Ser Pro Gly Lys Ser  Asn Thr Asn Ser Val  Thr Tyr Lys 
    1385                 1390                 1395             


Lys Arg  Glu Asn Ile Ile Phe  Leu Lys Pro Thr Leu  Pro Glu Glu 
    1400                 1405                 1410             


Ser Gly  Lys Ile Glu Leu Leu  Pro Gln Val Ser Ile  Gln Glu Glu 
    1415                 1420                 1425             


Glu Ile  Leu Pro Thr Glu Thr  Ser His Gly Ser Pro  Gly His Leu 
    1430                 1435                 1440             


Asn Leu  Met Lys Glu Val Phe  Leu Gln Lys Ile Gln  Gly Pro Thr 
    1445                 1450                 1455             


Lys Trp  Asn Lys Ala Lys Arg  His Gly Glu Ser Ile  Lys Gly Lys 
    1460                 1465                 1470             


Thr Glu  Ser Ser Lys Asn Thr  Arg Ser Lys Leu Leu  Asn His His 
    1475                 1480                 1485             


Ala Trp  Asp Tyr His Tyr Ala  Ala Gln Ile Pro Lys  Asp Met Trp 
    1490                 1495                 1500             


Lys Ser  Lys Glu Lys Ser Pro  Glu Ile Ile Ser Ile  Lys Gln Glu 
    1505                 1510                 1515             


Asp Thr  Ile Leu Ser Leu Arg  Pro His Gly Asn Ser  His Ser Ile 
    1520                 1525                 1530             


Gly Ala  Asn Glu Lys Gln Asn  Trp Pro Gln Arg Glu  Thr Thr Trp 
    1535                 1540                 1545             


Val Lys  Gln Gly Gln Thr Gln  Arg Thr Cys Ser Gln  Ile Pro Pro 
    1550                 1555                 1560             


Val Leu  Lys Arg His Gln Arg  Glu Leu Ser Ala Phe  Gln Ser Glu 
    1565                 1570                 1575             


Gln Glu  Ala Thr Asp Tyr Asp  Asp Ala Ile Thr Ile  Glu Thr Ile 
    1580                 1585                 1590             


Glu Asp  Phe Asp Ile Tyr Ser  Glu Asp Ile Lys Gln  Gly Pro Arg 
    1595                 1600                 1605             


Ser Phe  Gln Gln Lys Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu 
    1610                 1615                 1620             


Arg Leu  Trp Asp Tyr Gly Met  Ser Thr Ser His Val  Leu Arg Asn 
    1625                 1630                 1635             


Arg Tyr  Gln Ser Asp Asn Val  Pro Gln Phe Lys Lys  Val Val Phe 
    1640                 1645                 1650             


Gln Glu  Phe Thr Asp Gly Ser  Phe Ser Gln Pro Leu  Tyr Arg Gly 
    1655                 1660                 1665             


Glu Leu  Asn Glu His Leu Gly  Leu Leu Gly Pro Tyr  Ile Arg Ala 
    1670                 1675                 1680             


Glu Val  Glu Asp Asn Ile Met  Val Thr Phe Lys Asn  Gln Ala Ser 
    1685                 1690                 1695             


Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Ile Ser Tyr  Lys Glu Asp 
    1700                 1705                 1710             


Gln Arg  Gly Glu Glu Pro Arg  Arg Asn Phe Val Lys  Pro Asn Glu 
    1715                 1720                 1725             


Thr Lys  Ile Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1730                 1735                 1740             


Glu Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1745                 1750                 1755             


Asp Leu  Glu Arg Asp Met His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1760                 1765                 1770             


Ile Cys  His Ala Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1775                 1780                 1785             


Ser Val  Gln Glu Phe Ala Leu  Leu Phe Thr Ile Phe  Asp Glu Thr 
    1790                 1795                 1800             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Val Lys Arg Asn  Cys Lys Thr 
    1805                 1810                 1815             


Pro Cys  Asn Phe Gln Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr 
    1820                 1825                 1830             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1835                 1840                 1845             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1850                 1855                 1860             


Met Gly  Asn Asn Glu Asn Ile  Gln Ser Ile His Phe  Ser Gly His 
    1865                 1870                 1875             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1880                 1885                 1890             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Leu Glu Met  Ile Pro Ser 
    1895                 1900                 1905             


Arg Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1910                 1915                 1920             


Gln Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys 
    1925                 1930                 1935             


Gln Ile  Pro Leu Gly Met Ala  Ser Gly Ser Ile Arg  Asp Phe Gln 
    1940                 1945                 1950             


Ile Thr  Ala Ser Gly His Tyr  Gly Gln Trp Ala Pro  Asn Leu Ala 
    1955                 1960                 1965             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    1970                 1975                 1980             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Val 
    1985                 1990                 1995             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    2000                 2005                 2010             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    2015                 2020                 2025             


Trp Leu  Ser Tyr Gln Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    2030                 2035                 2040             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ser Phe Asn 
    2045                 2050                 2055             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Ser 
    2060                 2065                 2070             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    2075                 2080                 2085             


Asn Ser  Cys Ser Ile Pro Leu  Gly Met Glu Ser Lys  Val Ile Ser 
    2090                 2095                 2100             


Asp Thr  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    2105                 2110                 2115             


Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr 
    2120                 2125                 2130             


Asn Ala  Trp Arg Pro Gln Val  Asn Asp Pro Lys Gln  Trp Leu Gln 
    2135                 2140                 2145             


Val Asp  Leu Gln Lys Thr Met  Lys Val Thr Gly Ile  Ile Thr Gln 
    2150                 2155                 2160             


Gly Val  Lys Ser Leu Phe Thr  Ser Met Phe Val Lys  Glu Phe Leu 
    2165                 2170                 2175             


Ile Ser  Ser Ser Gln Asp Gly  His His Trp Thr Gln  Ile Leu Tyr 
    2180                 2185                 2190             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Ser Thr 
    2195                 2200                 2205             


Pro Met  Met Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    2210                 2215                 2220             


Arg Ile  His Pro Gln Ile Trp  Glu His Gln Ile Ala  Leu Arg Leu 
    2225                 2230                 2235             


Glu Ile  Leu Gly Cys Glu Ala  Gln Gln Gln Tyr 
    2240                 2245                 


<210>  74
<211>  2319
<212>  PRT
<213>  Mus musculus

<400>  74

Met Gln Ile Ala Leu Phe Ala Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Ile Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Ser 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Ser Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Lys Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Asp Glu Tyr Glu Asp Gln Thr Ser Gln Met Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Met Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu Tyr Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Asp Ser Tyr Thr Gln Ser Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Asp Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Ile His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Phe Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Ser Gln Trp Gln Lys Lys Asn Asn Asn Glu Glu Met Glu Asp Tyr Asp 
        355                 360                 365             


Asp Asp Leu Tyr Ser Glu Met Asp Met Phe Thr Leu Asp Tyr Asp Ser 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr 
385                 390                 395                 400 


Trp Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ser Val Pro Thr Ser Asp Asn Gly Ser Tyr Lys Ser Gln Tyr Leu Ser 
            420                 425                 430         


Asn Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Ser Pro Leu His Ala Arg Arg Leu Pro Arg 
            500                 505                 510         


Gly Ile Lys His Val Lys Asp Leu Pro Ile His Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Ile Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu 
        595                 600                 605             


Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Lys Thr Gln Pro Gln Asp 
    610                 615                 620                 


Pro Gly Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Glu Leu Thr Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


His Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Lys Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Ser Thr Ser Asp 
                725                 730                 735     


Tyr Tyr Glu Glu Ile Tyr Glu Asp Ile Pro Thr Gln Leu Val Asn Glu 
            740                 745                 750         


Asn Asn Val Ile Asp Pro Arg Ser Phe Phe Gln Asn Thr Asn His Pro 
        755                 760                 765             


Asn Thr Arg Lys Lys Lys Phe Lys Asp Ser Thr Ile Pro Lys Asn Asp 
    770                 775                 780                 


Met Glu Lys Ile Glu Pro Gln Phe Glu Glu Ile Ala Glu Met Leu Lys 
785                 790                 795                 800 


Val Gln Ser Val Ser Val Ser Asp Met Leu Met Leu Leu Gly Gln Ser 
                805                 810                 815     


His Pro Thr Pro His Gly Leu Phe Leu Ser Asp Gly Gln Glu Ala Ile 
            820                 825                 830         


Tyr Glu Ala Ile His Asp Asp His Ser Pro Asn Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Lys Val Thr Gln Leu Arg Pro Glu Ser His His Ser 
    850                 855                 860                 


Glu Lys Ile Val Phe Thr Pro Gln Pro Gly Leu Gln Leu Arg Ser Asn 
865                 870                 875                 880 


Lys Ser Leu Glu Thr Thr Ile Glu Val Lys Trp Lys Lys Leu Gly Leu 
                885                 890                 895     


Gln Val Ser Ser Leu Pro Ser Asn Leu Met Thr Thr Thr Ile Leu Ser 
            900                 905                 910         


Asp Asn Leu Lys Ala Thr Phe Glu Lys Thr Asp Ser Ser Gly Phe Pro 
        915                 920                 925             


Asp Met Pro Val His Ser Ser Ser Lys Leu Ser Thr Thr Ala Phe Gly 
    930                 935                 940                 


Lys Lys Ala Tyr Ser Leu Val Gly Ser His Val Pro Leu Asn Val Ser 
945                 950                 955                 960 


Glu Glu Asn Ser Asp Ser Asn Ile Leu Asp Ser Thr Leu Met Tyr Ser 
                965                 970                 975     


Gln Glu Ser Leu Pro Arg Asp Asn Ile Leu Ser Met Glu Asn Asp Arg 
            980                 985                 990         


Leu Leu Arg Glu Lys Arg Phe His  Gly Ile Ala Leu Leu  Thr Lys Asp 
        995                 1000                 1005             


Asn Thr  Leu Phe Lys Asp Asn  Val Ser Leu Met Lys  Thr Asn Lys 
    1010                 1015                 1020             


Thr Tyr  Asn His Ser Thr Thr  Asn Glu Lys Leu His  Thr Glu Ser 
    1025                 1030                 1035             


Pro Thr  Ser Ile Glu Asn Ser  Thr Thr Asp Leu Gln  Asp Ala Ile 
    1040                 1045                 1050             


Leu Lys  Val Asn Ser Glu Ile  Gln Glu Val Thr Ala  Leu Ile His 
    1055                 1060                 1065             


Asp Gly  Thr Leu Leu Gly Lys  Asn Ser Thr Tyr Leu  Arg Leu Asn 
    1070                 1075                 1080             


His Met  Leu Asn Arg Thr Thr  Ser Thr Lys Asn Lys  Asp Ile Phe 
    1085                 1090                 1095             


His Arg  Lys Asp Glu Asp Pro  Ile Pro Gln Asp Glu  Glu Asn Thr 
    1100                 1105                 1110             


Ile Met  Pro Phe Ser Lys Met  Leu Phe Leu Ser Glu  Ser Ser Asn 
    1115                 1120                 1125             


Trp Phe  Lys Lys Thr Asn Gly  Asn Asn Ser Leu Asn  Ser Glu Gln 
    1130                 1135                 1140             


Glu His  Ser Pro Lys Gln Leu  Val Tyr Leu Met Phe  Lys Lys Tyr 
    1145                 1150                 1155             


Val Lys  Asn Gln Ser Phe Leu  Ser Glu Lys Asn Lys  Val Thr Val 
    1160                 1165                 1170             


Glu Gln  Asp Gly Phe Thr Lys  Asn Ile Gly Leu Lys  Asp Met Ala 
    1175                 1180                 1185             


Phe Pro  His Asn Met Ser Ile  Phe Leu Thr Thr Leu  Ser Asn Val 
    1190                 1195                 1200             


His Glu  Asn Gly Arg His Asn  Gln Glu Lys Asn Ile  Gln Glu Glu 
    1205                 1210                 1215             


Ile Glu  Lys Glu Ala Leu Ile  Glu Glu Lys Val Val  Leu Pro Gln 
    1220                 1225                 1230             


Val His  Glu Ala Thr Gly Ser  Lys Asn Phe Leu Lys  Asp Ile Leu 
    1235                 1240                 1245             


Ile Leu  Gly Thr Arg Gln Asn  Ile Ser Leu Tyr Glu  Val His Val 
    1250                 1255                 1260             


Pro Val  Leu Gln Asn Ile Thr  Ser Ile Asn Asn Ser  Thr Asn Thr 
    1265                 1270                 1275             


Val Gln  Ile His Met Glu His  Phe Phe Lys Arg Arg  Lys Asp Lys 
    1280                 1285                 1290             


Glu Thr  Asn Ser Glu Gly Leu  Val Asn Lys Thr Arg  Glu Met Val 
    1295                 1300                 1305             


Lys Asn  Tyr Pro Ser Gln Lys  Asn Ile Thr Thr Gln  Arg Ser Lys 
    1310                 1315                 1320             


Arg Ala  Leu Gly Gln Phe Arg  Leu Ser Thr Gln Trp  Leu Lys Thr 
    1325                 1330                 1335             


Ile Asn  Cys Ser Thr Gln Cys  Ile Ile Lys Gln Ile  Asp His Ser 
    1340                 1345                 1350             


Lys Glu  Met Lys Lys Phe Ile  Thr Lys Ser Ser Leu  Ser Asp Ser 
    1355                 1360                 1365             


Ser Val  Ile Lys Ser Thr Thr  Gln Thr Asn Ser Ser  Asp Ser His 
    1370                 1375                 1380             


Ile Val  Lys Thr Ser Ala Phe  Pro Pro Ile Asp Leu  Lys Arg Ser 
    1385                 1390                 1395             


Pro Phe  Gln Asn Lys Phe Ser  His Val Gln Ala Ser  Ser Tyr Ile 
    1400                 1405                 1410             


Tyr Asp  Phe Lys Thr Lys Ser  Ser Arg Ile Gln Glu  Ser Asn Asn 
    1415                 1420                 1425             


Phe Leu  Lys Glu Thr Lys Ile  Asn Asn Pro Ser Leu  Ala Ile Leu 
    1430                 1435                 1440             


Pro Trp  Asn Met Phe Ile Asp  Gln Gly Lys Phe Thr  Ser Pro Gly 
    1445                 1450                 1455             


Lys Ser  Asn Thr Asn Ser Val  Thr Tyr Lys Lys Arg  Glu Asn Ile 
    1460                 1465                 1470             


Ile Phe  Leu Lys Pro Thr Leu  Pro Glu Glu Ser Gly  Lys Ile Glu 
    1475                 1480                 1485             


Leu Leu  Pro Gln Val Ser Ile  Gln Glu Glu Glu Ile  Leu Pro Thr 
    1490                 1495                 1500             


Glu Thr  Ser His Gly Ser Pro  Gly His Leu Asn Leu  Met Lys Glu 
    1505                 1510                 1515             


Val Phe  Leu Gln Lys Ile Gln  Gly Pro Thr Lys Trp  Asn Lys Ala 
    1520                 1525                 1530             


Lys Arg  His Gly Glu Ser Ile  Lys Gly Lys Thr Glu  Ser Ser Lys 
    1535                 1540                 1545             


Asn Thr  Arg Ser Lys Leu Leu  Asn His His Ala Trp  Asp Tyr His 
    1550                 1555                 1560             


Tyr Ala  Ala Gln Ile Pro Lys  Asp Met Trp Lys Ser  Lys Glu Lys 
    1565                 1570                 1575             


Ser Pro  Glu Ile Ile Ser Ile  Lys Gln Glu Asp Thr  Ile Leu Ser 
    1580                 1585                 1590             


Leu Arg  Pro His Gly Asn Ser  His Ser Ile Gly Ala  Asn Glu Lys 
    1595                 1600                 1605             


Gln Asn  Trp Pro Gln Arg Glu  Thr Thr Trp Val Lys  Gln Gly Gln 
    1610                 1615                 1620             


Thr Gln  Arg Thr Cys Ser Gln  Ile Pro Pro Val Leu  Lys Arg His 
    1625                 1630                 1635             


Gln Arg  Glu Leu Ser Ala Phe  Gln Ser Glu Gln Glu  Ala Thr Asp 
    1640                 1645                 1650             


Tyr Asp  Asp Ala Ile Thr Ile  Glu Thr Ile Glu Asp  Phe Asp Ile 
    1655                 1660                 1665             


Tyr Ser  Glu Asp Ile Lys Gln  Gly Pro Arg Ser Phe  Gln Gln Lys 
    1670                 1675                 1680             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1685                 1690                 1695             


Gly Met  Ser Thr Ser His Val  Leu Arg Asn Arg Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Asn Val  Pro Gln Phe Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp 
    1715                 1720                 1725             


Gly Ser  Phe Ser Gln Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His 
    1730                 1735                 1740             


Leu Gly  Leu Leu Gly Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn 
    1745                 1750                 1755             


Ile Met  Val Thr Phe Lys Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe 
    1760                 1765                 1770             


Tyr Ser  Ser Leu Ile Ser Tyr  Lys Glu Asp Gln Arg  Gly Glu Glu 
    1775                 1780                 1785             


Pro Arg  Arg Asn Phe Val Lys  Pro Asn Glu Thr Lys  Ile Tyr Phe 
    1790                 1795                 1800             


Trp Lys  Val Gln His His Met  Ala Pro Thr Glu Asp  Glu Phe Asp 
    1805                 1810                 1815             


Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val Asp Leu  Glu Arg Asp 
    1820                 1825                 1830             


Met His  Ser Gly Leu Ile Gly  Pro Leu Leu Ile Cys  His Ala Asn 
    1835                 1840                 1845             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Ser Val  Gln Glu Phe 
    1850                 1855                 1860             


Ala Leu  Leu Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1865                 1870                 1875             


Thr Glu  Asn Val Lys Arg Asn  Cys Lys Thr Pro Cys  Asn Phe Gln 
    1880                 1885                 1890             


Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1895                 1900                 1905             


Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1910                 1915                 1920             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Asn Asn Glu 
    1925                 1930                 1935             


Asn Ile  Gln Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1940                 1945                 1950             


Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr Asn Leu  Tyr Pro Gly 
    1955                 1960                 1965             


Val Phe  Glu Thr Leu Glu Met  Ile Pro Ser Arg Ala  Gly Ile Trp 
    1970                 1975                 1980             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu Gln Ala  Gly Met Ser 
    1985                 1990                 1995             


Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys Gln Ile  Pro Leu Gly 
    2000                 2005                 2010             


Met Ala  Ser Gly Ser Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    2015                 2020                 2025             


His Tyr  Gly Gln Trp Ala Pro  Asn Leu Ala Arg Leu  His Tyr Ser 
    2030                 2035                 2040             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    2045                 2050                 2055             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Val His Gly  Ile Lys Thr 
    2060                 2065                 2070             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    2075                 2080                 2085             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Leu  Ser Tyr Gln 
    2090                 2095                 2100             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    2105                 2110                 2115             


Ser Ser  Gly Ile Lys His Asn  Ser Phe Asn Pro Pro  Ile Ile Ala 
    2120                 2125                 2130             


Arg Tyr  Ile Arg Leu His Pro  Thr His Ser Ser Ile  Arg Ser Thr 
    2135                 2140                 2145             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Ile 
    2150                 2155                 2160             


Pro Leu  Gly Met Glu Ser Lys  Val Ile Ser Asp Thr  Gln Ile Thr 
    2165                 2170                 2175             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    2180                 2185                 2190             


Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr Asn Ala  Trp Arg Pro 
    2195                 2200                 2205             


Gln Val  Asn Asp Pro Lys Gln  Trp Leu Gln Val Asp  Leu Gln Lys 
    2210                 2215                 2220             


Thr Met  Lys Val Thr Gly Ile  Ile Thr Gln Gly Val  Lys Ser Leu 
    2225                 2230                 2235             


Phe Thr  Ser Met Phe Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    2240                 2245                 2250             


Asp Gly  His His Trp Thr Gln  Ile Leu Tyr Asn Gly  Lys Val Lys 
    2255                 2260                 2265             


Val Phe  Gln Gly Asn Gln Asp  Ser Ser Thr Pro Met  Met Asn Ser 
    2270                 2275                 2280             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    2285                 2290                 2295             


Ile Trp  Glu His Gln Ile Ala  Leu Arg Leu Glu Ile  Leu Gly Cys 
    2300                 2305                 2310             


Glu Ala  Gln Gln Gln Tyr 
    2315                 


<210>  75
<211>  2254
<212>  PRT
<213>  Ovis aries

<400>  75

Met His Ile Lys Leu Cys Thr Cys Leu Phe Leu Cys Leu Trp Pro Cys 
1               5                   10                  15      


Ser Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Thr Arg Ser Glu Leu Leu Ser Glu Leu His Val Asn Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Lys Pro Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Arg Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Ala Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Phe Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Ile Gly Val Ser Tyr Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Ala Tyr Lys Asp Glu Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Lys Ser His Thr Tyr Val Trp His Ile 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Val Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Ile Cys Arg Glu Gly Thr Leu Ile Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Gly Lys Asn Glu Ser Leu Thr His Val Met 
225                 230                 235                 240 


Asp Ser Ala Ser Val Leu His Thr Ile Asn Gly Tyr Ile Asn Arg Ser 
                245                 250                 255     


Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser Val Tyr Trp His Val 
            260                 265                 270         


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
        275                 280                 285             


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
    290                 295                 300                 


Pro Ile Thr Phe Leu Thr Ala Gln Thr Val Leu Met Asp Cys Gly Gln 
305                 310                 315                 320 


Phe Leu Leu Phe Cys Arg Ile Ser Ser His Gln His Asp Gly Met Glu 
                325                 330                 335     


Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Arg Leu Trp Met 
            340                 345                 350         


Lys Asn Asn Gln Glu Glu Asp Tyr Asp Asp Gly Leu Asp Asp Ser Asp 
        355                 360                 365             


Met Asp Val Val Arg Phe Asp Gly Asp Ser Val Pro Pro Phe Ile Gln 
    370                 375                 380                 


Met Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile 
385                 390                 395                 400 


Ala Ala Glu Glu Asp Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Ser 
                405                 410                 415     


Asn Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn His Gly Pro Gln Arg 
            420                 425                 430         


Ile Gly Arg Lys Tyr Arg Lys Val Arg Phe Ile Ala Tyr Thr Asp Gly 
        435                 440                 445             


Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly 
    450                 455                 460                 


Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys 
465                 470                 475                 480 


Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp 
                485                 490                 495     


Val Ser Pro Leu His Ser Gly Arg Phe Pro Lys Gly Val Lys His Leu 
            500                 505                 510         


Lys Asp Met Pro Ile Leu Pro Gly Glu Val Phe Lys Tyr Lys Trp Thr 
        515                 520                 525             


Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 
    530                 535                 540                 


Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu Lys Asp Leu Ala Ser Gly 
545                 550                 555                 560 


Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 
                565                 570                 575     


Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 
            580                 585                 590         


Phe Asp Glu Asn Lys Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 
        595                 600                 605             


Leu Pro Ser Gly Val Gln Pro Gln Asp Pro Glu Phe Gln Val Ser Asn 
    610                 615                 620                 


Val Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
625                 630                 635                 640 


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly Ala 
                645                 650                 655     


Gln Ile Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
            660                 665                 670         


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
        675                 680                 685             


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys 
    690                 695                 700                 


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
705                 710                 715                 720 


Asp Ser Cys Asp Arg Asn Val Gly Asp Tyr Tyr Asp Thr Tyr Glu Ala 
                725                 730                 735     


Ile Pro Thr Phe Leu Leu Ser Glu Asn Asn Val Ile Glu Pro Arg Ser 
            740                 745                 750         


Phe Ser Gln Asn Ser Arg Tyr Pro Asn Thr Arg Gln Lys Gln Phe Lys 
        755                 760                 765             


Pro Thr Met Thr Pro Glu Asn Asp Met Glu Lys Ile Asp Pro Gln Phe 
    770                 775                 780                 


Gly Glu Lys Val Gln Leu Leu Lys Glu Gln Ser Val Ser Ser Ser Asp 
785                 790                 795                 800 


Leu Leu Met Leu Leu Gly Gln Asn Pro Thr Pro His Arg Leu Thr Leu 
                805                 810                 815     


Ser Asp Leu Gln Glu Asp Arg Asn Glu Pro Thr Asp His Leu Pro Gly 
            820                 825                 830         


Pro Thr Glu Arg Asn Lys Gly Pro Ser Pro Ser Glu Val Ala His Leu 
        835                 840                 845             


Gly Pro Glu Leu His His Ser Gly Glu Arg Val Phe Thr Gln Glu Pro 
    850                 855                 860                 


Gln Leu Pro Leu Arg Leu Asn Glu Asn Leu Gly Thr Thr Ile Met Ala 
865                 870                 875                 880 


Glu Leu Ser Lys Leu Asn Leu Lys Ile Ser Ser Ser Ser Asn Asn Leu 
                885                 890                 895     


Met Pro Leu Pro Thr Ile Pro Ser Asp Lys Leu Ser Ala Gly Thr Glu 
            900                 905                 910         


Lys Thr Gly Ser Phe Gly Pro Pro Asn Met Pro Val Asn Phe Asn Ser 
        915                 920                 925             


Gln Leu Gly Ala Ile Val Phe Gly Lys Asn Leu Ser His Val Ile Glu 
    930                 935                 940                 


Ser His Val Pro Leu His Leu Ser Lys Glu Asp Asn Asn Ser Lys Leu 
945                 950                 955                 960 


Leu Glu Ala Ala Leu Met Asn Asn Gln Lys Ser Ser Leu Gly Glu Asn 
                965                 970                 975     


Val Leu Ser Met Glu Ser Asp Arg Leu Phe Lys Glu Glu Arg Val His 
            980                 985                 990         


Gly Pro Val Ser Leu Asn Lys Asp  Asp Thr Leu Phe Lys  Val Asn Ile 
        995                 1000                 1005             


Ser Leu  Val Lys Thr Gly Lys  Ala Pro Ala Asn Ser  Thr Thr Asn 
    1010                 1015                 1020             


Arg Lys  Thr His Ile Asp Asp  Pro Thr Val Leu Ile  Glu Asn Ser 
    1025                 1030                 1035             


Thr Ser  Val Trp Gln Asp Ile  Val Ile Asp Ser Asn  Thr Asn Phe 
    1040                 1045                 1050             


Gln Glu  Val Thr Ser Leu Ile  His Asp Glu Leu Phe  Met His Lys 
    1055                 1060                 1065             


Asn Thr  Thr Ser Phe Gly Leu  Ser His Met Ser Asn  Lys Thr Thr 
    1070                 1075                 1080             


Ser Ser  Lys Lys Arg Glu Met  Ile His Gln Glu Lys  Glu Gly Pro 
    1085                 1090                 1095             


Glu Pro  Leu Asp Thr Lys Tyr  Pro Asp Thr Pro Phe  Phe Lys Thr 
    1100                 1105                 1110             


Leu Phe  Leu Pro Asp Ser Thr  Asn Val Ile Lys Arg  Thr His Gly 
    1115                 1120                 1125             


Lys Asn  Ser Leu Ser Ser Gly  Gln Arg Pro Ser Pro  Lys Gln Phe 
    1130                 1135                 1140             


Thr Ser  Ser Val Ser Glu Asn  Ser Val Lys Asp Gln  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Asn Lys Val Val  Ala Gly Glu Asp Glu  Phe Ser Lys 
    1160                 1165                 1170             


Asp Thr  Ser Leu Glu Glu Met  Ile Phe Pro Asn Ser  Lys Ser Ile 
    1175                 1180                 1185             


Val Leu  Thr Asn Leu Ala Asn  Val Gln Glu Asn Asp  Thr Asp Asn 
    1190                 1195                 1200             


Gln Glu  Lys Ile Ser Gln Glu  Glu Thr Glu Arg Lys  Glu Thr Leu 
    1205                 1210                 1215             


Ile Pro  Lys Asn Ala Val Leu  Pro Gln Val Tyr Thr  Ala Ile Gly 
    1220                 1225                 1230             


Thr Lys  Asn Ser Leu Lys Asn  Leu Phe Ser Leu Ser  Thr Lys Gln 
    1235                 1240                 1245             


Asn Ala  Gly Gly Leu Asp Glu  Glu Thr Tyr Thr Gln  Asp Asn Arg 
    1250                 1255                 1260             


Ser Leu  Ser Asp Ser Ala Lys  Arg Ala Gly Ile His  Ala Ala His 
    1265                 1270                 1275             


Phe Ser  Lys Gly Arg Val Glu  Ala Asn Val Lys Gly  Leu Gly Asn 
    1280                 1285                 1290             


Gln Thr  Lys Gln Met Val Glu  Lys Ser Pro Ser Thr  Thr Arg Leu 
    1295                 1300                 1305             


Ser Pro  Ile Pro Ser Gln Gln  Asp Ala Val Pro Leu  Arg Ser Leu 
    1310                 1315                 1320             


Arg Ser  Ile Arg Pro Thr Asp  Val Thr Lys Ile Pro  Phe Glu Asp 
    1325                 1330                 1335             


Asn Ser  Ser His Pro Pro Ala  Ser Thr Tyr Gly Tyr  Asn Leu Gly 
    1340                 1345                 1350             


Thr Ser  His Ser Gly Val Gln  Glu Thr Ser His Phe  Leu Leu Gly 
    1355                 1360                 1365             


Ala Lys  Lys Asn Asn Leu Ser  Leu Ala Leu Leu Thr  Leu Glu Val 
    1370                 1375                 1380             


Ile Gly  Ser Gln Arg Lys Ser  Ser Thr Leu Gly Lys  Gln Ala Ala 
    1385                 1390                 1395             


Asn Pro  Leu Met Tyr Lys Lys  Leu Glu Asn Thr Phe  Leu Leu Lys 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Ala Ser  Gly Lys Val Val His  Gln Glu Gly 
    1415                 1420                 1425             


Leu Pro  Thr Lys Thr Ser Lys  Val Ser Pro Ala His  Leu Asp Leu 
    1430                 1435                 1440             


Arg Glu  Glu Ile Phe Leu Gln  Lys Thr Gln Gly Leu  Val Lys Leu 
    1445                 1450                 1455             


Ser Lys  Val Tyr Arg Pro Gly  Lys Val Pro Ser Leu  Lys Trp Thr 
    1460                 1465                 1470             


Thr Glu  Ser Ser Glu Lys Ile  Pro Ser Lys Leu Leu  Gly Pro Leu 
    1475                 1480                 1485             


Ser Trp  Asp Asn Gln Ser Ala  Thr Leu Ile Pro Arg  Glu Ser Trp 
    1490                 1495                 1500             


Lys Ser  Leu Glu Arg Ser His  Lys Leu Thr Ser Leu  Lys Thr Lys 
    1505                 1510                 1515             


Asp Ile  Thr Leu Pro Leu Asp  Pro Ser Glu Asn Tyr  Tyr Ser Ile 
    1520                 1525                 1530             


Ala Ile  Thr Asn Glu Glu Asp  Lys Ala Gln Arg Glu  Ala Pro Trp 
    1535                 1540                 1545             


Pro Lys  Gln Gly Gly Thr Gly  Arg Val Cys Cys Gln  Asn Pro Pro 
    1550                 1555                 1560             


Ser Leu  Lys Arg His Gln Arg  Glu Ile Thr Leu Thr  Thr Phe Gln 
    1565                 1570                 1575             


Pro Glu  Pro Asp Lys Thr Asp  Tyr Asp Asp Thr Leu  Ser Ile Glu 
    1580                 1585                 1590             


Thr Lys  Arg Glu Asp Phe Asp  Ile Tyr Gly Glu Asp  Glu Asn Gln 
    1595                 1600                 1605             


Asp Pro  Arg Ser Phe Gln Lys  Arg Thr Arg His Tyr  Phe Ile Ala 
    1610                 1615                 1620             


Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Arg  Ser Pro His 
    1625                 1630                 1635             


Ala Leu  Arg Asn Arg Ser Gln  Asn Gly Gly Val Pro  Gln Phe Lys 
    1640                 1645                 1650             


Lys Val  Val Phe Glu Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Ala 
    1655                 1660                 1665             


Val Tyr  Arg Gly Gln Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 
    1670                 1675                 1680             


Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Lys 
    1685                 1690                 1695             


Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 
    1700                 1705                 1710             


Tyr Asn  Gly Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Lys Phe 
    1715                 1720                 1725             


Val Lys  Pro Asn Glu Thr Gln  Ser Tyr Phe Trp Lys  Val Gln His 
    1730                 1735                 1740             


His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 
    1745                 1750                 1755             


Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Val His  Ser Gly Leu 
    1760                 1765                 1770             


Ile Gly  Pro Ile Leu Ile Cys  Arg Val Asp Thr Leu  Ser Ala Ala 
    1775                 1780                 1785             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1790                 1795                 1800             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Ala Glu  Asn Met Ala 
    1805                 1810                 1815             


Arg Asn  Cys Val Ala Pro Cys  His Val Gln Pro Glu  Asp Pro Thr 
    1820                 1825                 1830             


Phe Gln  Glu Lys Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Val Met 
    1835                 1840                 1845             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln His Gln  Arg Ile Arg 
    1850                 1855                 1860             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1865                 1870                 1875             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Thr  Glu Glu Tyr 
    1880                 1885                 1890             


Lys Met  Ala Val Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    1895                 1900                 1905             


Glu Met  Leu Pro Ser Lys Val  Gly Thr Trp Arg Ile  Glu Cys Leu 
    1910                 1915                 1920             


Ile Gly  Glu His Leu Gln Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    1925                 1930                 1935             


Tyr Ser  Lys Glu Cys Gln Ile  Pro Leu Gly Met Ala  Ser Gly Arg 
    1940                 1945                 1950             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    1955                 1960                 1965             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    1970                 1975                 1980             


Trp Ser  Thr Lys Asp Pro Ser  Pro Trp Ile Lys Val  Asp Leu Leu 
    1985                 1990                 1995             


Ala Pro  Met Ile Ile His Ser  Ile Leu Thr Gln Gly  Ala Arg Gln 
    2000                 2005                 2010             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    2015                 2020                 2025             


Leu Asp  Gly Gln Arg Trp Gln  Gly Tyr Arg Gly Asn  Ser Thr Gly 
    2030                 2035                 2040             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Val Lys 
    2045                 2050                 2055             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    2060                 2065                 2070             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    2075                 2080                 2085             


Met Gly  Cys Asp Leu Asn Ser  Cys Asn Met Pro Leu  Gly Met Glu 
    2090                 2095                 2100             


Asn Lys  Ala Ile Ser Asp Thr  Gln Ile Thr Ala Ser  Ser His Leu 
    2105                 2110                 2115             


Ser Asn  Met Phe Ala Thr Trp  Ser Pro Ser Gln Ala  Arg Leu Asn 
    2120                 2125                 2130             


Leu Gln  Gly Arg Thr Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    2135                 2140                 2145             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Arg Val Thr 
    2150                 2155                 2160             


Gly Ile  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    2165                 2170                 2175             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Glu Gly  His Asn Trp 
    2180                 2185                 2190             


Thr Pro  Phe Leu Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    2195                 2200                 2205             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Thr Leu Asp  Pro Pro Leu 
    2210                 2215                 2220             


Phe Thr  Arg Phe Leu Arg Ile  His Pro Gln Ser Trp  Val His His 
    2225                 2230                 2235             


Ile Ala  Leu Arg Leu Glu Phe  Trp Gly Cys Glu Ala  Gln Gln Gln 
    2240                 2245                 2250             


Tyr 
    


<210>  76
<211>  2247
<212>  PRT
<213>  Mus musculus

<400>  76

Met Gln Ile Ala Leu Phe Ala Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Ile Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Ser 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Ser Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Lys Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Asp Glu Tyr Glu Asp Gln Thr Ser Gln Met Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Met Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu Tyr Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Asp Ser Tyr Thr Gln Ser Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Asp Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Ile His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Phe Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Ser Gln Trp Gln Lys Lys Asn Asn Asn Glu Glu Met Glu Asp Tyr Asp 
        355                 360                 365             


Asp Asp Leu Tyr Ser Glu Met Asp Met Phe Thr Leu Asp Tyr Asp Ser 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr 
385                 390                 395                 400 


Trp Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ser Val Pro Thr Ser Asp Asn Gly Ser Tyr Lys Ser Gln Tyr Leu Ser 
            420                 425                 430         


Asn Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Ser Pro Leu His Ala Arg Arg Leu Pro Arg 
            500                 505                 510         


Gly Ile Lys His Val Lys Asp Leu Pro Ile His Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Ile Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu 
        595                 600                 605             


Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Lys Thr Gln Pro Gln Asp 
    610                 615                 620                 


Pro Gly Phe Gln Ala Ser Asn Ile Met His Ser Leu Trp Val Leu Gly 
625                 630                 635                 640 


Cys His Asn Ser Asp Phe Arg Lys Arg Gly Met Thr Ala Leu Leu Lys 
                645                 650                 655     


Val Ser Ser Cys Asp Lys Ser Thr Ser Asp Tyr Tyr Glu Glu Ile Tyr 
            660                 665                 670         


Glu Asp Ile Pro Thr Gln Leu Val Asn Glu Asn Asn Val Ile Asp Pro 
        675                 680                 685             


Arg Ser Phe Phe Gln Asn Thr Asn His Pro Asn Thr Arg Lys Lys Lys 
    690                 695                 700                 


Phe Lys Asp Ser Thr Ile Pro Lys Asn Asp Met Glu Lys Ile Glu Pro 
705                 710                 715                 720 


Gln Phe Glu Glu Ile Ala Glu Met Leu Lys Val Gln Ser Val Ser Val 
                725                 730                 735     


Ser Asp Met Leu Met Leu Leu Gly Gln Ser His Pro Thr Pro His Gly 
            740                 745                 750         


Leu Phe Leu Ser Asp Gly Gln Glu Ala Ile Tyr Glu Ala Ile His Asp 
        755                 760                 765             


Asp His Ser Pro Asn Ala Ile Asp Ser Asn Glu Gly Pro Ser Lys Val 
    770                 775                 780                 


Thr Gln Leu Arg Pro Glu Ser His His Ser Glu Lys Ile Val Phe Thr 
785                 790                 795                 800 


Pro Gln Pro Gly Leu Gln Leu Arg Ser Asn Lys Ser Leu Glu Thr Thr 
                805                 810                 815     


Ile Glu Val Lys Trp Lys Lys Leu Gly Leu Gln Val Ser Ser Leu Pro 
            820                 825                 830         


Ser Asn Leu Met Thr Thr Thr Ile Leu Ser Asp Asn Leu Lys Ala Thr 
        835                 840                 845             


Phe Glu Lys Thr Asp Ser Ser Gly Phe Pro Asp Met Pro Val His Ser 
    850                 855                 860                 


Ser Ser Lys Leu Ser Thr Thr Ala Phe Gly Lys Lys Ala Tyr Ser Leu 
865                 870                 875                 880 


Val Gly Ser His Val Pro Leu Asn Val Ser Glu Glu Asn Ser Asp Ser 
                885                 890                 895     


Asn Ile Leu Asp Ser Thr Leu Met Tyr Ser Gln Glu Ser Leu Pro Arg 
            900                 905                 910         


Asp Asn Ile Leu Ser Met Glu Asn Asp Arg Leu Leu Arg Glu Lys Arg 
        915                 920                 925             


Phe His Gly Ile Ala Leu Leu Thr Lys Asp Asn Thr Leu Phe Lys Asp 
    930                 935                 940                 


Asn Val Ser Leu Met Lys Thr Asn Lys Thr Tyr Asn His Ser Thr Thr 
945                 950                 955                 960 


Asn Glu Lys Leu His Thr Glu Ser Pro Thr Ser Ile Glu Asn Ser Thr 
                965                 970                 975     


Thr Asp Leu Gln Asp Ala Ile Leu Lys Val Asn Ser Glu Ile Gln Glu 
            980                 985                 990         


Val Thr Ala Leu Ile His Asp Gly  Thr Leu Leu Gly Lys  Asn Ser Thr 
        995                 1000                 1005             


Tyr Leu  Arg Leu Asn His Met  Leu Asn Arg Thr Thr  Ser Thr Lys 
    1010                 1015                 1020             


Asn Lys  Asp Ile Phe His Arg  Lys Asp Glu Asp Pro  Ile Pro Gln 
    1025                 1030                 1035             


Asp Glu  Glu Asn Thr Ile Met  Pro Phe Ser Lys Met  Leu Phe Leu 
    1040                 1045                 1050             


Ser Glu  Ser Ser Asn Trp Phe  Lys Lys Thr Asn Gly  Asn Asn Ser 
    1055                 1060                 1065             


Leu Asn  Ser Glu Gln Glu His  Ser Pro Lys Gln Leu  Val Tyr Leu 
    1070                 1075                 1080             


Met Phe  Lys Lys Tyr Val Lys  Asn Gln Ser Phe Leu  Ser Glu Lys 
    1085                 1090                 1095             


Asn Lys  Val Thr Val Glu Gln  Asp Gly Phe Thr Lys  Asn Ile Gly 
    1100                 1105                 1110             


Leu Lys  Asp Met Ala Phe Pro  His Asn Met Ser Ile  Phe Leu Thr 
    1115                 1120                 1125             


Thr Leu  Ser Asn Val His Glu  Asn Gly Arg His Asn  Gln Glu Lys 
    1130                 1135                 1140             


Asn Ile  Gln Glu Glu Ile Glu  Lys Glu Ala Leu Ile  Glu Glu Lys 
    1145                 1150                 1155             


Val Val  Leu Pro Gln Val His  Glu Ala Thr Gly Ser  Lys Asn Phe 
    1160                 1165                 1170             


Leu Lys  Asp Ile Leu Ile Leu  Gly Thr Arg Gln Asn  Ile Ser Leu 
    1175                 1180                 1185             


Tyr Glu  Val His Val Pro Val  Leu Gln Asn Ile Thr  Ser Ile Asn 
    1190                 1195                 1200             


Asn Ser  Thr Asn Thr Val Gln  Ile His Met Glu His  Phe Phe Lys 
    1205                 1210                 1215             


Arg Arg  Lys Asp Lys Glu Thr  Asn Ser Glu Gly Leu  Val Asn Lys 
    1220                 1225                 1230             


Thr Arg  Glu Met Val Lys Asn  Tyr Pro Ser Gln Lys  Asn Ile Thr 
    1235                 1240                 1245             


Thr Gln  Arg Ser Lys Arg Ala  Leu Gly Gln Phe Arg  Leu Ser Thr 
    1250                 1255                 1260             


Gln Trp  Leu Lys Thr Ile Asn  Cys Ser Thr Gln Cys  Ile Ile Lys 
    1265                 1270                 1275             


Gln Ile  Asp His Ser Lys Glu  Met Lys Lys Phe Ile  Thr Lys Ser 
    1280                 1285                 1290             


Ser Leu  Ser Asp Ser Ser Val  Ile Lys Ser Thr Thr  Gln Thr Asn 
    1295                 1300                 1305             


Ser Ser  Asp Ser His Ile Val  Lys Thr Ser Ala Phe  Pro Pro Ile 
    1310                 1315                 1320             


Asp Leu  Lys Arg Ser Pro Phe  Gln Asn Lys Phe Ser  His Val Gln 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Ile Tyr Asp  Phe Lys Thr Lys Ser  Ser Arg Ile 
    1340                 1345                 1350             


Gln Glu  Ser Asn Asn Phe Leu  Lys Glu Thr Lys Ile  Asn Asn Pro 
    1355                 1360                 1365             


Ser Leu  Ala Ile Leu Pro Trp  Asn Met Phe Ile Asp  Gln Gly Lys 
    1370                 1375                 1380             


Phe Thr  Ser Pro Gly Lys Ser  Asn Thr Asn Ser Val  Thr Tyr Lys 
    1385                 1390                 1395             


Lys Arg  Glu Asn Ile Ile Phe  Leu Lys Pro Thr Leu  Pro Glu Glu 
    1400                 1405                 1410             


Ser Gly  Lys Ile Glu Leu Leu  Pro Gln Val Ser Ile  Gln Glu Glu 
    1415                 1420                 1425             


Glu Ile  Leu Pro Thr Glu Thr  Ser His Gly Ser Pro  Gly His Leu 
    1430                 1435                 1440             


Asn Leu  Met Lys Glu Val Phe  Leu Gln Lys Ile Gln  Gly Pro Thr 
    1445                 1450                 1455             


Lys Trp  Asn Lys Ala Lys Arg  His Gly Glu Ser Ile  Lys Gly Lys 
    1460                 1465                 1470             


Thr Glu  Ser Ser Lys Asn Thr  Arg Ser Lys Leu Leu  Asn His His 
    1475                 1480                 1485             


Ala Trp  Asp Tyr His Tyr Ala  Ala Gln Ile Pro Lys  Asp Met Trp 
    1490                 1495                 1500             


Lys Ser  Lys Glu Lys Ser Pro  Glu Ile Ile Ser Ile  Lys Gln Glu 
    1505                 1510                 1515             


Asp Thr  Ile Leu Ser Leu Arg  Pro His Gly Asn Ser  His Ser Ile 
    1520                 1525                 1530             


Gly Ala  Asn Glu Lys Gln Asn  Trp Pro Gln Arg Glu  Thr Thr Trp 
    1535                 1540                 1545             


Val Lys  Gln Gly Gln Thr Gln  Arg Thr Cys Ser Gln  Ile Pro Pro 
    1550                 1555                 1560             


Val Leu  Lys Arg His Gln Arg  Glu Leu Ser Ala Phe  Gln Ser Glu 
    1565                 1570                 1575             


Gln Glu  Ala Thr Asp Tyr Asp  Asp Ala Ile Thr Ile  Glu Thr Ile 
    1580                 1585                 1590             


Glu Asp  Phe Asp Ile Tyr Ser  Glu Asp Ile Lys Gln  Gly Pro Arg 
    1595                 1600                 1605             


Ser Phe  Gln Gln Lys Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu 
    1610                 1615                 1620             


Arg Leu  Trp Asp Tyr Gly Met  Ser Thr Ser His Val  Leu Arg Asn 
    1625                 1630                 1635             


Arg Tyr  Gln Ser Asp Asn Val  Pro Gln Phe Lys Lys  Val Val Phe 
    1640                 1645                 1650             


Gln Glu  Phe Thr Asp Gly Ser  Phe Ser Gln Pro Leu  Tyr Arg Gly 
    1655                 1660                 1665             


Glu Leu  Asn Glu His Leu Gly  Leu Leu Gly Pro Tyr  Ile Arg Ala 
    1670                 1675                 1680             


Glu Val  Glu Asp Asn Ile Met  Val Thr Phe Lys Asn  Gln Ala Ser 
    1685                 1690                 1695             


Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Ile Ser Tyr  Lys Glu Asp 
    1700                 1705                 1710             


Gln Arg  Gly Glu Glu Pro Arg  Arg Asn Phe Val Lys  Pro Asn Glu 
    1715                 1720                 1725             


Thr Lys  Ile Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1730                 1735                 1740             


Glu Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1745                 1750                 1755             


Asp Leu  Glu Arg Asp Met His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1760                 1765                 1770             


Ile Cys  His Ala Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1775                 1780                 1785             


Ser Val  Gln Glu Phe Ala Leu  Leu Phe Thr Ile Phe  Asp Glu Thr 
    1790                 1795                 1800             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Val Lys Arg Asn  Cys Lys Thr 
    1805                 1810                 1815             


Pro Cys  Asn Phe Gln Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr 
    1820                 1825                 1830             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1835                 1840                 1845             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1850                 1855                 1860             


Met Gly  Asn Asn Glu Asn Ile  Gln Ser Ile His Phe  Ser Gly His 
    1865                 1870                 1875             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1880                 1885                 1890             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Leu Glu Met  Ile Pro Ser 
    1895                 1900                 1905             


Arg Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1910                 1915                 1920             


Gln Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys 
    1925                 1930                 1935             


Gln Ile  Pro Leu Gly Met Ala  Ser Gly Ser Ile Arg  Asp Phe Gln 
    1940                 1945                 1950             


Ile Thr  Ala Ser Gly His Tyr  Gly Gln Trp Ala Pro  Asn Leu Ala 
    1955                 1960                 1965             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    1970                 1975                 1980             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Val 
    1985                 1990                 1995             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    2000                 2005                 2010             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    2015                 2020                 2025             


Trp Leu  Ser Tyr Gln Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    2030                 2035                 2040             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ser Phe Asn 
    2045                 2050                 2055             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Ser 
    2060                 2065                 2070             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    2075                 2080                 2085             


Asn Ser  Cys Ser Ile Pro Leu  Gly Met Glu Ser Lys  Val Ile Ser 
    2090                 2095                 2100             


Asp Thr  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    2105                 2110                 2115             


Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr 
    2120                 2125                 2130             


Asn Ala  Trp Arg Pro Gln Val  Asn Asp Pro Lys Gln  Trp Leu Gln 
    2135                 2140                 2145             


Val Asp  Leu Gln Lys Thr Met  Lys Val Thr Gly Ile  Ile Thr Gln 
    2150                 2155                 2160             


Gly Val  Lys Ser Leu Phe Thr  Ser Met Phe Val Lys  Glu Phe Leu 
    2165                 2170                 2175             


Ile Ser  Ser Ser Gln Asp Gly  His His Trp Thr Gln  Ile Leu Tyr 
    2180                 2185                 2190             


Asn Gly  Lys Val Phe Gln Gly  Asn Gln Asp Ser Ser  Thr Pro Met 
    2195                 2200                 2205             


Met Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    2210                 2215                 2220             


His Pro  Gln Ile Trp Glu His  Gln Ile Ala Leu Arg  Leu Glu Ile 
    2225                 2230                 2235             


Leu Gly  Cys Glu Ala Gln Gln  Gln Tyr 
    2240                 2245         


<210>  77
<211>  2133
<212>  PRT
<213>  Sus scrofa

<400>  77

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu 
1               5                   10                  15      


Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val 
    50                  55                  60                  


Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser 
65                  70                  75                  80  


Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg 
        195                 200                 205             


Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met 
225                 230                 235                 240 


Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His 
                325                 330                 335     


His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn 
        355                 360                 365             


Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ala Val Pro Ser Pro Ser Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn 
            420                 425                 430         


Ser Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Ala Arg Phe Val 
        435                 440                 445             


Ala Tyr Thr Asp Val Thr Phe Lys Thr Arg Lys Ala Ile Pro Tyr Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Lys Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Ser Ala Leu His Pro Gly Arg Leu Leu Lys 
            500                 505                 510         


Gly Trp Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Thr Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Ser Ile Asn Leu Glu Lys 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Ala Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Asp Gly Leu Gln Pro Gln Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Leu Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Tyr Ser Cys Asp Arg Asp Ile Gly Asp 
                725                 730                 735     


Tyr Tyr Asp Asn Thr Tyr Glu Asp Ile Pro Gly Phe Leu Leu Ser Gly 
            740                 745                 750         


Lys Asn Val Ile Glu Pro Arg Ser Phe Ala Gln Asn Ser Arg Pro Pro 
        755                 760                 765             


Ser Ala Ser Gln Lys Gln Phe Gln Thr Ile Thr Ser Pro Glu Asp Asp 
    770                 775                 780                 


Val Glu Leu Asp Pro Gln Ser Gly Glu Arg Thr Gln Ala Leu Glu Glu 
785                 790                 795                 800 


Leu Ser Val Pro Ser Gly Asp Gly Ser Met Leu Leu Gly Gln Asn Pro 
                805                 810                 815     


Ala Pro His Gly Ser Ser Ser Ser Asp Leu Gln Glu Ala Arg Asn Glu 
            820                 825                 830         


Ala Asp Asp Tyr Leu Pro Gly Ala Arg Glu Arg Asn Thr Ala Pro Ser 
        835                 840                 845             


Ala Ala Ala Arg Leu Arg Pro Glu Leu His His Ser Ala Glu Arg Val 
    850                 855                 860                 


Leu Thr Pro Glu Pro Glu Lys Glu Leu Lys Lys Leu Asp Ser Lys Met 
865                 870                 875                 880 


Ser Ser Ser Ser Asp Leu Leu Lys Thr Ser Pro Thr Ile Pro Ser Asp 
                885                 890                 895     


Thr Leu Ser Ala Glu Thr Glu Arg Thr His Ser Leu Gly Pro Pro His 
            900                 905                 910         


Pro Gln Val Asn Phe Arg Ser Gln Leu Gly Ala Ile Val Leu Gly Lys 
        915                 920                 925             


Asn Ser Ser His Phe Ile Gly Ala Gly Val Pro Leu Gly Ser Thr Glu 
    930                 935                 940                 


Glu Asp His Glu Ser Ser Leu Gly Glu Asn Val Ser Pro Val Glu Ser 
945                 950                 955                 960 


Asp Gly Ile Phe Glu Lys Glu Arg Ala His Gly Pro Ala Ser Leu Thr 
                965                 970                 975     


Lys Asp Asp Val Leu Phe Lys Val Asn Ile Ser Leu Val Lys Thr Asn 
            980                 985                 990         


Lys Ala Arg Val Tyr Leu Lys Thr  Asn Arg Lys Ile His  Ile Asp Asp 
        995                 1000                 1005             


Ala Ala  Leu Leu Thr Glu Asn  Arg Ala Ser Ala Thr  Phe Met Asp 
    1010                 1015                 1020             


Lys Asn  Thr Thr Ala Ser Gly  Leu Asn His Val Ser  Asn Trp Ile 
    1025                 1030                 1035             


Lys Gly  Pro Leu Gly Lys Asn  Pro Leu Ser Ser Glu  Arg Gly Pro 
    1040                 1045                 1050             


Ser Pro  Glu Leu Leu Thr Ser  Ser Gly Ser Gly Lys  Ser Val Lys 
    1055                 1060                 1065             


Gly Gln  Ser Ser Gly Gln Gly  Arg Ile Arg Val Ala  Val Glu Glu 
    1070                 1075                 1080             


Glu Glu  Leu Ser Lys Gly Lys  Glu Met Met Leu Pro  Asn Ser Glu 
    1085                 1090                 1095             


Leu Thr  Phe Leu Thr Asn Ser  Ala Asp Val Gln Gly  Asn Asp Thr 
    1100                 1105                 1110             


His Ser  Gln Gly Lys Lys Ser  Arg Glu Glu Met Glu  Arg Arg Glu 
    1115                 1120                 1125             


Lys Leu  Val Gln Glu Lys Val  Asp Leu Pro Gln Val  Tyr Thr Ala 
    1130                 1135                 1140             


Thr Gly  Thr Lys Asn Phe Leu  Arg Asn Ile Phe His  Gln Ser Thr 
    1145                 1150                 1155             


Glu Pro  Ser Val Glu Gly Phe  Asp Gly Gly Ser His  Ala Pro Val 
    1160                 1165                 1170             


Pro Gln  Asp Ser Arg Ser Leu  Asn Asp Ser Ala Glu  Arg Ala Glu 
    1175                 1180                 1185             


Thr His  Ile Ala His Phe Ser  Ala Ile Arg Glu Glu  Ala Pro Leu 
    1190                 1195                 1200             


Glu Ala  Pro Gly Asn Arg Thr  Gly Pro Gly Pro Arg  Ser Ala Val 
    1205                 1210                 1215             


Pro Arg  Arg Val Lys Gln Ser  Leu Lys Gln Ile Arg  Leu Pro Leu 
    1220                 1225                 1230             


Glu Glu  Ile Lys Pro Glu Arg  Gly Val Val Leu Asn  Ala Thr Ser 
    1235                 1240                 1245             


Thr Arg  Trp Ser Glu Ser Ser  Pro Ile Leu Gln Gly  Ala Lys Arg 
    1250                 1255                 1260             


Asn Asn  Leu Ser Leu Pro Phe  Leu Thr Leu Glu Met  Ala Gly Gly 
    1265                 1270                 1275             


Gln Gly  Lys Ile Ser Ala Leu  Gly Lys Ser Ala Ala  Gly Pro Leu 
    1280                 1285                 1290             


Ala Ser  Gly Lys Leu Glu Lys  Ala Val Leu Ser Ser  Ala Gly Leu 
    1295                 1300                 1305             


Ser Glu  Ala Ser Gly Lys Ala  Glu Phe Leu Pro Lys  Val Arg Val 
    1310                 1315                 1320             


His Arg  Glu Asp Leu Leu Pro  Gln Lys Thr Ser Asn  Val Ser Cys 
    1325                 1330                 1335             


Ala His  Gly Asp Leu Gly Gln  Glu Ile Phe Leu Gln  Lys Thr Arg 
    1340                 1345                 1350             


Gly Pro  Val Asn Leu Asn Lys  Val Asn Arg Pro Gly  Arg Thr Pro 
    1355                 1360                 1365             


Ser Lys  Leu Leu Gly Pro Pro  Met Pro Lys Glu Trp  Glu Ser Leu 
    1370                 1375                 1380             


Glu Lys  Ser Pro Lys Ser Thr  Ala Leu Arg Thr Lys  Asp Ile Ile 
    1385                 1390                 1395             


Ser Leu  Pro Leu Asp Arg His  Glu Ser Asn His Ser  Ile Ala Ala 
    1400                 1405                 1410             


Lys Asn  Glu Gly Gln Ala Glu  Thr Gln Arg Glu Ala  Ala Trp Thr 
    1415                 1420                 1425             


Lys Gln  Gly Gly Pro Gly Arg  Leu Cys Ala Pro Lys  Pro Pro Val 
    1430                 1435                 1440             


Leu Arg  Arg His Gln Arg Asp  Ile Ser Leu Pro Thr  Phe Gln Pro 
    1445                 1450                 1455             


Glu Glu  Asp Lys Met Asp Tyr  Asp Asp Ile Phe Ser  Thr Glu Thr 
    1460                 1465                 1470             


Lys Gly  Glu Asp Phe Asp Ile  Tyr Gly Glu Asp Glu  Asn Gln Asp 
    1475                 1480                 1485             


Pro Arg  Ser Phe Gln Lys Arg  Thr Arg His Tyr Phe  Ile Ala Ala 
    1490                 1495                 1500             


Val Glu  Gln Leu Trp Asp Tyr  Gly Met Ser Glu Ser  Pro Arg Ala 
    1505                 1510                 1515             


Leu Arg  Asn Arg Ala Gln Asn  Gly Glu Val Pro Arg  Phe Lys Lys 
    1520                 1525                 1530             


Val Val  Phe Arg Glu Phe Ala  Asp Gly Ser Phe Thr  Gln Pro Ser 
    1535                 1540                 1545             


Tyr Arg  Gly Glu Leu Asn Lys  His Leu Gly Leu Leu  Gly Pro Tyr 
    1550                 1555                 1560             


Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met Val Thr  Phe Lys Asn 
    1565                 1570                 1575             


Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr 
    1580                 1585                 1590             


Pro Asp  Asp Gln Glu Gln Gly  Ala Glu Pro Arg His  Asn Phe Val 
    1595                 1600                 1605             


Gln Pro  Asn Glu Thr Arg Thr  Tyr Phe Trp Lys Val  Gln His His 
    1610                 1615                 1620             


Met Ala  Pro Thr Glu Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr 
    1625                 1630                 1635             


Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val His Ser  Gly Leu Ile 
    1640                 1645                 1650             


Gly Pro  Leu Leu Ile Cys Arg  Ala Asn Thr Leu Asn  Ala Ala His 
    1655                 1660                 1665             


Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile 
    1670                 1675                 1680             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Val Glu Arg 
    1685                 1690                 1695             


Asn Cys  Arg Ala Pro Cys His  Leu Gln Met Glu Asp  Pro Thr Leu 
    1700                 1705                 1710             


Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn Gly Tyr  Val Met Asp 
    1715                 1720                 1725             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asn Gln Arg  Ile Arg Trp 
    1730                 1735                 1740             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1745                 1750                 1755             


Phe Ser  Gly His Val Phe Ser  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1760                 1765                 1770             


Met Ala  Val Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    1775                 1780                 1785             


Met Leu  Pro Ser Lys Val Gly  Ile Trp Arg Ile Glu  Cys Leu Ile 
    1790                 1795                 1800             


Gly Glu  His Leu Gln Ala Gly  Met Ser Thr Thr Phe  Leu Val Tyr 
    1805                 1810                 1815             


Ser Lys  Glu Cys Gln Ala Pro  Leu Gly Met Ala Ser  Gly Arg Ile 
    1820                 1825                 1830             


Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala 
    1835                 1840                 1845             


Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp 
    1850                 1855                 1860             


Ser Thr  Lys Asp Pro His Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    1865                 1870                 1875             


Pro Met  Ile Ile His Gly Ile  Met Thr Gln Gly Ala  Arg Gln Lys 
    1880                 1885                 1890             


Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    1895                 1900                 1905             


Asp Gly  Arg Asn Trp Gln Ser  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    1910                 1915                 1920             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ala Ser Gly  Ile Lys His 
    1925                 1930                 1935             


Asn Ile  Phe Asn Pro Pro Ile  Val Ala Arg Tyr Ile  Arg Leu His 
    1940                 1945                 1950             


Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met 
    1955                 1960                 1965             


Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro Leu Gly  Met Gln Asn 
    1970                 1975                 1980             


Lys Ala  Ile Ser Asp Ser Gln  Ile Thr Ala Ser Ser  His Leu Ser 
    1985                 1990                 1995             


Asn Ile  Phe Ala Thr Trp Ser  Pro Ser Gln Ala Arg  Leu His Leu 
    2000                 2005                 2010             


Gln Gly  Arg Thr Asn Ala Trp  Arg Pro Arg Val Ser  Ser Ala Glu 
    2015                 2020                 2025             


Glu Trp  Leu Gln Val Asp Leu  Gln Lys Thr Val Lys  Val Thr Gly 
    2030                 2035                 2040             


Ile Thr  Thr Gln Gly Val Lys  Ser Leu Leu Ser Ser  Met Tyr Val 
    2045                 2050                 2055             


Lys Glu  Phe Leu Val Ser Ser  Ser Gln Asp Gly Arg  Arg Trp Thr 
    2060                 2065                 2070             


Leu Phe  Leu Gln Asp Gly His  Thr Lys Val Phe Gln  Gly Asn Gln 
    2075                 2080                 2085             


Asp Ser  Ser Thr Pro Val Val  Asn Ala Leu Asp Pro  Pro Leu Phe 
    2090                 2095                 2100             


Thr Arg  Tyr Leu Arg Ile His  Pro Thr Ser Trp Ala  Gln His Ile 
    2105                 2110                 2115             


Ala Leu  Arg Leu Glu Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    2120                 2125                 2130             


<210>  78
<211>  2258
<212>  PRT
<213>  Rattus norvegicus

<400>  78

Met Arg Ala Ala Arg Gly Leu Cys Phe Phe Leu Ser Leu Cys Ala Leu 
1               5                   10                  15      


Cys Ser Cys Ala Thr Arg Lys Tyr Tyr Leu Gly Ala Val Glu Leu Pro 
            20                  25                  30          


Trp Asp Tyr Val Ser Gly Gly Ala Ser Gly Ala Gln Arg Ser Asp Ser 
        35                  40                  45              


Arg Phe Pro Pro Gly Thr Pro Ala Pro Ser Ala His Val Val His Thr 
    50                  55                  60                  


Lys Thr Val Phe Val Glu Tyr Met Asp Arg Phe Phe His Thr Ala Lys 
65                  70                  75                  80  


Pro Arg Pro Leu Trp Met Gly Leu Leu Gly Pro Thr Ile Trp Thr Glu 
                85                  90                  95      


Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
            100                 105                 110         


Val Ser Leu His Ala Val Gly Met Ser Phe Trp Lys Ala Ser Glu Gly 
        115                 120                 125             


Ala Ala Tyr Asp Asp His Ser Ser Pro Ala Glu Lys Asp Asp Asp Lys 
    130                 135                 140                 


Val Leu Pro Gly Glu Ser His Thr Tyr Ala Trp Gln Val Leu Gly Glu 
145                 150                 155                 160 


Ser Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ala Tyr Leu 
                165                 170                 175     


Ser His Val Asp Leu Val Arg Asp Leu Asn Ser Gly Leu Val Gly Ala 
            180                 185                 190         


Leu Leu Val Cys Lys Glu Gly Arg Leu Ser Ala Glu Arg Thr Arg Met 
        195                 200                 205             


Pro Pro His Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Arg Ser 
    210                 215                 220                 


Trp His Ala Ala Thr Arg Asp Pro Ala Ser Thr Glu Ala Gln Pro Thr 
225                 230                 235                 240 


Val His Thr Val Asn Gly Tyr Thr Asn Arg Thr Leu Pro Gly Leu Thr 
                245                 250                 255     


Gly Cys Arg Gly Thr Ser Val Tyr Trp His Val Met Ala Val Gly Thr 
            260                 265                 270         


Thr Pro Asp Ile His Ser Ile Leu Leu Glu Gly His Thr Phe Ser Val 
        275                 280                 285             


Arg Ser His Arg Gln Ala Ser Leu Glu Ile Ser Pro Met Thr Leu Leu 
    290                 295                 300                 


Thr Ala Gln Thr Trp Leu Met Asp Leu Gly Arg Phe Leu Leu Phe Cys 
305                 310                 315                 320 


His Ile Ser Ser His Arg His Gly Gly Met Glu Ala Tyr Val Gln Val 
                325                 330                 335     


Asp Asn Cys Pro Glu Ala Pro Gln Gly Gln Gly Lys Arg Asp Glu Asp 
            340                 345                 350         


Thr Glu Asp Tyr Asp Asp Leu Asp Ser Glu Met Asp Val Phe Thr Trp 
        355                 360                 365             


Asp Pro Asp Ala Ala Pro Phe Val Gln Val Arg Ser Ala Ala Lys Arg 
    370                 375                 380                 


His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Gly Asp Trp 
385                 390                 395                 400 


Asp Tyr Ala Pro Ala Ala Ala Thr Leu Glu Asp Gly Ser Leu Arg Asn 
                405                 410                 415     


Arg Tyr Leu Gly Arg Gly Pro Gly Arg Ile Gly Ser Lys Tyr Lys Lys 
            420                 425                 430         


Val Arg Phe Val Ala Tyr Thr Asp Gly Thr Phe His Thr Arg Glu Ala 
        435                 440                 445             


Thr Pro Arg Glu Ala Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val 
    450                 455                 460                 


Gly Asp Ser Leu Leu Ile Val Phe Lys Asn Arg Ala Ser Arg Ala Tyr 
465                 470                 475                 480 


Asn Ile His Pro His Gly Ile Arg Asp Val Gly Ala Val His Ala Gly 
                485                 490                 495     


Arg Leu Pro Arg Gly Val Lys His Val Lys Asp Leu Pro Ile Arg Pro 
            500                 505                 510         


Gly Glu Thr Phe Lys Tyr Arg Trp Thr Leu Thr Ala Glu Asp Gly Pro 
        515                 520                 525             


Ala Arg Ser Asp Ala Arg Cys Val Thr Arg Tyr Tyr Ala Ser Ala Val 
    530                 535                 540                 


Asp Pro Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile 
545                 550                 555                 560 


Cys Cys Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp 
                565                 570                 575     


Glu Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp 
            580                 585                 590         


Tyr Ile Ser Glu Asn Met Arg Arg Phe Leu Pro Asp Glu Ala His Val 
        595                 600                 605             


Gln Leu Gln Asp Pro Glu Phe Glu Ala Ser Asn Leu Met His Ser Ile 
    610                 615                 620                 


Asn Gly Tyr Val Phe Asp Gly Leu Glu Leu Arg Val Cys Leu His Glu 
625                 630                 635                 640 


Val Ala Ala Trp His Val Leu Ser Val Gly Ala Gln Thr Asp Phe Leu 
                645                 650                 655     


Ser Val Phe Phe Ser Gly His Thr Phe Arg His Arg Ala Val Tyr Ala 
            660                 665                 670         


Asp Thr Leu Thr Val Phe Pro His Ser Gly Val Thr Val Phe Met Ser 
        675                 680                 685             


Met Asp Asn Pro Gly Val Trp Val Leu Gly Cys His Asn Pro Asp Phe 
    690                 695                 700                 


Arg Glu Ser Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Glu 
705                 710                 715                 720 


Gly Val Ser Asp Tyr Tyr Gly Glu Thr Tyr Glu Gly Val Leu Ala Pro 
                725                 730                 735     


Leu Ala Asn Asp Asn Ala Val Asp Pro Arg Ser Phe Ser Gln Asn Ser 
            740                 745                 750         


Asn His Leu His Ser Arg Lys Lys Lys Ser Asn Thr Pro Met Arg Phe 
        755                 760                 765             


Pro Leu Ser His Pro Thr Gln His Gly Ser Phe Trp Ser Asp Ser Gln 
    770                 775                 780                 


Gly Asp Val His Asp Ala Val His Arg Ala His Ser Pro Ala Ala Ala 
785                 790                 795                 800 


His Ser Asn Glu Gly Pro Ala Glu Ala Ala Gln Leu Glu Pro Lys Pro 
                805                 810                 815     


His Pro Gly Glu Lys Met Ala Leu Pro Pro Ser Trp Leu Arg Ala Lys 
            820                 825                 830         


Arg Ser Leu Val Thr Thr Met Glu Ala Lys Arg Lys Lys Leu Asp Leu 
        835                 840                 845             


Gln Val Gln Val Ser Gly Leu Pro Asp Asp Arg Thr Thr Ala Val Val 
    850                 855                 860                 


Ala Pro Asp Asp Pro Met Ala Ala Cys Lys Lys Ala Gly Ser Ser Gly 
865                 870                 875                 880 


Phe Pro Asp Glu Ser Ser Pro Ala Ala Leu Gly Lys Lys Met Tyr Pro 
                885                 890                 895     


Arg Ile Arg Pro His Gly Pro Leu Ser Ile Ile Glu Gly Asn Arg Asp 
            900                 905                 910         


Ser Asn Ser Ser Asp Ser Thr Leu Met Tyr Arg Leu Gly Ser Pro Pro 
        915                 920                 925             


Gly Asp Ala Thr Ser Trp Thr Glu Asn Arg Arg Gly Leu Gly Glu Lys 
    930                 935                 940                 


Arg Ser His Arg Val Ala Phe Leu Ala Arg Gly Asn Thr Leu Leu Ser 
945                 950                 955                 960 


Asp Val Asp Glu Lys Ser His Ala Pro Gly Pro Thr Ser Val Gly Asn 
                965                 970                 975     


Ser Thr Ala Ala Val Gln Asp Thr Ile Leu Glu Ile Cys Ser Glu Ile 
            980                 985                 990         


Leu Glu Val Thr Pro Pro Ile His  Asp Arg Ile Leu Ser  Asp Lys Ser 
        995                 1000                 1005             


Ala Thr  Tyr Leu Arg Pro His  Arg Thr Pro Asp Arg  Ile Thr Ser 
    1010                 1015                 1020             


Thr Glu  Arg Lys Asp Ile Arg  His Glu Lys Asp Gly  Asp Leu Val 
    1025                 1030                 1035             


Pro Gln  Asp Ala Asp Asp Thr  Ser Ala Pro Phe Ser  Glu Ala Pro 
    1040                 1045                 1050             


Phe Leu  Ser Glu Ser Thr Asp  Trp Leu Lys Glu Ala  Asn Gly Asp 
    1055                 1060                 1065             


Asn Ser  Ala Lys Pro Glu Gln  Glu Pro Ser Pro Glu  Gln Leu Val 
    1070                 1075                 1080             


Tyr Leu  Met Tyr Ile Lys Cys  Met Glu Asn Gln Ser  Phe Ser Ser 
    1085                 1090                 1095             


Glu Lys  Asn Lys Met Ile Ala  Gly Gln Gly Gly Phe  Thr Lys Asn 
    1100                 1105                 1110             


Thr Gly  Leu Glu Asp Thr Val  Phe Pro Arg Lys Thr  Ser Val Phe 
    1115                 1120                 1125             


Leu Thr  Thr Val Ala Lys Arg  Gln Glu Ser Gly Arg  His Asn Gln 
    1130                 1135                 1140             


Glu Asn  Ile Pro Gln Ala Val  Thr Glu Lys Glu Ala  Pro Ile Glu 
    1145                 1150                 1155             


Glu Lys  Gly Ala Leu Pro Gln  Val His Ile Ala Thr  Gly Ser Lys 
    1160                 1165                 1170             


Asn Phe  Pro Arg Asp Met Phe  Val Leu Gly Thr Gly  Gln Asn Ile 
    1175                 1180                 1185             


Asn Leu  His Glu Glu Thr Tyr  Val Pro Val His Lys  Asn Val Pro 
    1190                 1195                 1200             


Trp Thr  Arg Asn Pro Thr Asp  Thr Arg Gln Ile Pro  Met Val His 
    1205                 1210                 1215             


Phe Phe  Lys Lys Arg Lys Glu  Glu Glu Thr Asn Ser  Gly Gly Leu 
    1220                 1225                 1230             


Val Asn  Lys Thr Arg Glu Thr  Val Arg Asn Tyr Pro  Ser Gln Lys 
    1235                 1240                 1245             


Asn Ser  Val Ala Arg Arg Arg  Glu Gln Ala Ser Gly  Arg Ile Lys 
    1250                 1255                 1260             


Ala Ser  Ala Arg Trp Leu Pro  Asp Val Asn Arg Ser  Ile Gln Ser 
    1265                 1270                 1275             


Leu Leu  Lys Gln Ile Asp His  Arg Lys Glu Arg Lys  Lys Phe Ile 
    1280                 1285                 1290             


Ile Glu  Ser Arg Ser Ala Asp  Ser Ser Gly Thr Lys  Ser Pro Thr 
    1295                 1300                 1305             


Gln Thr  Asn His Ser Pro Ser  His Val Val Lys Met  Ser Ala Phe 
    1310                 1315                 1320             


Pro Pro  Arg Asp Ile Arg Arg  Ile Glu Ser Arg Asp  Ser Ser Gln 
    1325                 1330                 1335             


Val Trp  Val Ser Ser Tyr Ala  Tyr Asp Phe Glu Thr  Gly Ser Ser 
    1340                 1345                 1350             


Arg Ile  Arg Glu Ser Ser Pro  Phe Leu Asn Glu Thr  Glu Thr Asp 
    1355                 1360                 1365             


Asn Pro  Ser Leu Ala Val Pro  Pro Arg Glu Arg Phe  Val Arg Arg 
    1370                 1375                 1380             


Gly Arg  Phe Ala Ser Pro Glu  Lys Val Asn Thr His  Ser Ala Pro 
    1385                 1390                 1395             


Cys Asp  Lys Pro Glu Asn Val  Val Ser Ser Glu Pro  Val Ser Pro 
    1400                 1405                 1410             


Gly Glu  Ala Val Thr Val Ala  Leu Pro Pro His Val  Ser Thr Gln 
    1415                 1420                 1425             


Glu Glu  Glu Pro Leu Pro Ala  Gly Ser Ser Cys Glu  Arg Arg Gly 
    1430                 1435                 1440             


His Val  Asp Leu Phe Leu Glu  Ile Ser Leu Gln Arg  Thr Arg Gly 
    1445                 1450                 1455             


Pro Val  Glu Arg Ser Arg Gly  Arg Arg Ser Gly Gly  Asp Thr Glu 
    1460                 1465                 1470             


Gly His  Thr Glu Asn Pro Gly  Lys Thr Pro Ser Pro  Leu Pro Gln 
    1475                 1480                 1485             


Met Pro  Lys Asp Gln Arg Gly  Ser Glu Ala Gly Tyr  Pro Lys Ile 
    1490                 1495                 1500             


Cys Arg  Trp Arg Asp Gly Thr  Val Leu Pro Pro Arg  Pro His Asn 
    1505                 1510                 1515             


Leu Ser  Leu Gly Ala Lys Lys  Lys Pro Asn Leu Pro  Arg Arg Glu 
    1520                 1525                 1530             


Ala Thr  Arg Val Glu Gln Gly  Glu Ala Pro Ser Leu  Val Ser Pro 
    1535                 1540                 1545             


Glu Pro  Leu Val Leu Arg Arg  Arg Pro Arg Glu Ala  Ser Thr Leu 
    1550                 1555                 1560             


Leu Pro  Gly Gly Glu Met Arg  Glu Asp Asp Gly Asp  Gly Val Thr 
    1565                 1570                 1575             


Ala Glu  Tyr Asp Asp Asp Asp  Asp Val Met Ala Glu  Tyr Asp Asp 
    1580                 1585                 1590             


Asp Ala  Val Thr Val Asp Thr  Pro Glu Asp Phe Asp  Ile Tyr Gly 
    1595                 1600                 1605             


Glu Glu  Ala Gly Gln Gly Pro  Arg Gly Phe Gln Gln  Lys Thr Arg 
    1610                 1615                 1620             


His Tyr  Phe Ile Ala Ala Val  Glu Glu Leu Trp Asp  Tyr Gly Val 
    1625                 1630                 1635             


Arg Val  Ser Pro Gly Ala Leu  Gly Asp Arg Ala Trp  Ser Gly Asp 
    1640                 1645                 1650             


Ala Ala  Arg Phe Arg Lys Val  Val Phe Arg Glu Phe  Thr Asp Gly 
    1655                 1660                 1665             


Ser Phe  Thr Gln Arg Val His  Arg Gly Glu Leu Asp  Ala His Leu 
    1670                 1675                 1680             


Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile 
    1685                 1690                 1695             


Val Val  Thr Phe Arg Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr 
    1700                 1705                 1710             


Ser Ser  Leu Val Ser Tyr Pro  Glu Ala Asp Gly Gly  Ala Ala Pro 
    1715                 1720                 1725             


Arg Ser  Asn Phe Val Arg Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1730                 1735                 1740             


Arg Val  Arg Pro His Met Ala  Pro Thr Asp Gly Glu  Phe Asp Cys 
    1745                 1750                 1755             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Arg Asp Leu 
    1760                 1765                 1770             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Ala Ser Thr 
    1775                 1780                 1785             


Leu His  Pro Ser His Ala Arg  Pro Leu Ala Val Gln  Glu Phe Ala 
    1790                 1795                 1800             


Leu Leu  Phe Ala Val Phe Asp  Glu Thr Lys Ser Trp  Tyr Cys Ala 
    1805                 1810                 1815             


Glu Asn  Leu Asp Arg Lys Cys  Arg Pro Pro Arg Gly  Thr Pro Ala 
    1820                 1825                 1830             


Gly Asp  Pro Ala Trp Arg Glu  Glu Tyr Arg Phe His  Ala Val Asn 
    1835                 1840                 1845             


Gly Tyr  Val Ala Asp Ala Leu  Leu Gly Leu Val Met  Ala Glu Gly 
    1850                 1855                 1860             


Arg Arg  Thr Arg Trp His Leu  Leu Ser Met Gly Asp  Pro Gly His 
    1865                 1870                 1875             


Ala Gln  Ser Val His Phe Ser  Ala His Ser Val Thr  Val Arg Asp 
    1880                 1885                 1890             


Gly Gly  Glu His Arg Thr Ala  Val Cys Asn Leu Tyr  Pro Gly Val 
    1895                 1900                 1905             


Phe Thr  Thr Val Glu Met Leu  Pro Ser Arg Ala Gly  Ile Trp Arg 
    1910                 1915                 1920             


Val Glu  Ser Leu Val Gly Glu  His Leu Arg Ala Gly  Met Ser Ala 
    1925                 1930                 1935             


Leu Phe  Leu Val Tyr Ser Thr  Arg Cys Gln Val Pro  Leu Gly Met 
    1940                 1945                 1950             


Ala Ser  Gly Tyr Ile Arg Asp  Ser Gln Ile Thr Ala  Ser Gly Tyr 
    1955                 1960                 1965             


His Gly  Leu Trp Thr Pro Gln  Leu Ala Arg Leu His  Asn Ala Gly 
    1970                 1975                 1980             


Ser Val  Asn Ala Trp Ser Ala  Lys Glu Pro Phe Ala  Trp Ile Lys 
    1985                 1990                 1995             


Val Asp  Leu Leu Ala Pro Met  Ile Leu His Gly Ile  Glu Thr Gln 
    2000                 2005                 2010             


Gly Ala  Arg His Arg Leu Ser  Ser Leu Tyr Val Ser  Gln Phe Ile 
    2015                 2020                 2025             


Ile Met  Tyr Ser Leu Asp Gly  Lys Gln Trp Leu Ser  Tyr Arg Gly 
    2030                 2035                 2040             


Asn Ser  Thr Gly Ser Leu Met  Val Phe Phe Gly Asn  Val Asp Ala 
    2045                 2050                 2055             


Ser Thr  Val Arg His Asn Arg  Phe Asp Pro Pro Ile  Val Ala Arg 
    2060                 2065                 2070             


Tyr Ile  Arg Val His Pro Thr  His Ala Ser Ile Arg  Thr Ala Leu 
    2075                 2080                 2085             


Arg Met  Glu Leu Leu Gly Cys  Asp Leu Asn Ser Cys  Ser Ala Pro 
    2090                 2095                 2100             


Leu Gly  Met Glu Ser Gly Trp  Ile Ser Asp Thr Gln  Val Thr Ala 
    2105                 2110                 2115             


Ser Ser  His Leu Ser Thr Thr  Phe Ser Ala Trp Pro  Pro Ala Leu 
    2120                 2125                 2130             


Ala Arg  Leu His Leu Arg Gly  Gly Ala Asn Ala Trp  Arg Pro Gln 
    2135                 2140                 2145             


Val Asn  Asp Pro Thr Gln Trp  Leu Gln Val Asp Leu  Gln Arg Thr 
    2150                 2155                 2160             


Val Lys  Val Thr Gly Val Val  Thr Gln Gly Ala Arg  Ser Leu Leu 
    2165                 2170                 2175             


Thr Ala  Met Phe Val Lys Lys  Phe Leu Val Ser Thr  Ser Gln Asp 
    2180                 2185                 2190             


Gly Arg  His Trp Thr His Val  Leu Gln Asp Gly Lys  Val Lys Val 
    2195                 2200                 2205             


Phe Gln  Gly Asn Arg Asp Ala  Ser Thr Pro Met Val  Asn Ser Leu 
    2210                 2215                 2220             


His Pro  Pro Arg Phe Thr Arg  Tyr Leu Arg Ile His  Pro Gln Val 
    2225                 2230                 2235             


Trp Glu  Arg Gln Ile Ala Leu  Arg Leu Glu Ile Leu  Gly Cys Glu 
    2240                 2245                 2250             


Ala Gln  Gln Leu Asp 
    2255             


<210>  79
<211>  2277
<212>  PRT
<213>  Rattus norvegicus

<400>  79

Met Arg Ala Ala Arg Gly Leu Cys Phe Phe Leu Ser Leu Cys Ala Leu 
1               5                   10                  15      


Cys Ser Cys Ala Thr Arg Lys Tyr Tyr Leu Gly Ala Val Glu Leu Pro 
            20                  25                  30          


Trp Asp Tyr Val Ser Gly Gly Ala Ser Gly Ala Gln Arg Ser Asp Ser 
        35                  40                  45              


Arg Phe Pro Pro Gly Thr Pro Ala Pro Ser Ala His Val Val His Thr 
    50                  55                  60                  


Lys Thr Val Phe Val Glu Tyr Met Asp Arg Phe Phe His Thr Ala Lys 
65                  70                  75                  80  


Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Trp Thr Glu 
                85                  90                  95      


Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
            100                 105                 110         


Val Ser Leu His Ala Val Gly Met Ser Phe Trp Lys Ala Ser Glu Gly 
        115                 120                 125             


Ala Ala Tyr Asp Asp His Ser Ser Pro Ala Glu Lys Asp Asp Asp Lys 
    130                 135                 140                 


Val Leu Pro Gly Glu Ser His Thr Tyr Ala Trp Gln Val Leu Gly Glu 
145                 150                 155                 160 


Ser Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ala Tyr Leu 
                165                 170                 175     


Ser His Val Asp Leu Val Arg Asp Leu Asn Ser Gly Leu Val Gly Ala 
            180                 185                 190         


Leu Leu Val Cys Lys Glu Gly Arg Leu Ser Ala Asp Arg Thr Arg Met 
        195                 200                 205             


Pro Pro His Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Arg Ser 
    210                 215                 220                 


Trp His Ala Ala Thr Arg Asp Pro Ala Ser Thr Glu Ala Gln Pro Thr 
225                 230                 235                 240 


Val His Thr Val Asn Gly Tyr Thr Asn Arg Thr Leu Pro Gly Leu Thr 
                245                 250                 255     


Gly Cys Arg Gly Thr Ser Val Tyr Trp His Val Met Ala Val Gly Thr 
            260                 265                 270         


Thr Pro Asp Ile His Ser Ile Leu Leu Glu Gly His Thr Phe Ser Val 
        275                 280                 285             


Arg Ser His Arg Gln Ala Ser Leu Glu Ile Ser Pro Met Thr Leu Leu 
    290                 295                 300                 


Thr Ala Gln Thr Trp Leu Met Asp Leu Gly Arg Phe Leu Leu Phe Cys 
305                 310                 315                 320 


His Ile Ser Ser His Arg His Gly Gly Met Glu Ala Tyr Val Gln Val 
                325                 330                 335     


Asp Asn Cys Pro Glu Ala Pro Gln Gly Gln Gly Lys Arg Asp Glu Asp 
            340                 345                 350         


Thr Glu Asp Tyr Asp Asp Leu Asp Ser Glu Met Asp Val Phe Thr Trp 
        355                 360                 365             


Asp Pro Asp Ala Ala Pro Phe Val Gln Val Arg Ser Ala Ala Lys Arg 
    370                 375                 380                 


His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Gly Asp Trp 
385                 390                 395                 400 


Asp Tyr Ala Pro Ala Ala Ala Thr Leu Glu Asp Gly Ser Leu Arg Asn 
                405                 410                 415     


Arg Tyr Leu Gly Arg Gly Pro Gly Arg Ile Gly Ser Lys Tyr Lys Lys 
            420                 425                 430         


Val Arg Phe Val Ala Tyr Thr Asp Gly Thr Phe His Thr Arg Glu Ala 
        435                 440                 445             


Thr Pro Arg Glu Ala Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val 
    450                 455                 460                 


Gly Asp Ser Leu Leu Ile Val Phe Lys Asn Arg Ala Ser Arg Ala Tyr 
465                 470                 475                 480 


Asn Ile His Pro His Gly Ile Arg Asp Val Gly Ala Val His Ala Gly 
                485                 490                 495     


Arg Leu Pro Arg Gly Val Lys His Val Lys Asp Leu Pro Ile Arg Pro 
            500                 505                 510         


Gly Glu Thr Phe Lys Tyr Arg Trp Thr Leu Thr Ala Glu Asp Gly Pro 
        515                 520                 525             


Ala Arg Ser Asp Ala Arg Cys Val Thr Arg Tyr Tyr Ala Ser Ala Val 
    530                 535                 540                 


Asp Pro Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile 
545                 550                 555                 560 


Cys Cys Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp 
                565                 570                 575     


Glu Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp 
            580                 585                 590         


Tyr Ile Ser Glu Asn Met Arg Arg Phe Leu Pro Asp Glu Ala His Val 
        595                 600                 605             


Gln Leu Gln Asp Pro Glu Phe Glu Ala Ser Asn Leu Met His Ser Ile 
    610                 615                 620                 


Asn Gly Tyr Val Phe Asp Gly Leu Glu Leu Arg Val Cys Leu His Glu 
625                 630                 635                 640 


Val Ala Ala Trp His Val Leu Ser Val Gly Ala Gln Thr Asp Phe Leu 
                645                 650                 655     


Ser Val Phe Phe Ser Gly His Thr Phe Arg His Arg Ala Val Tyr Ala 
            660                 665                 670         


Asp Thr Leu Thr Val Phe Pro His Ser Gly Val Thr Val Phe Met Ser 
        675                 680                 685             


Met Asp Asn Pro Gly Val Trp Val Leu Gly Cys His Asn Pro Asp Phe 
    690                 695                 700                 


Arg Glu Ser Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Glu 
705                 710                 715                 720 


Gly Val Ser Asp Tyr Tyr Gly Glu Thr Tyr Glu Gly Val Leu Ala Pro 
                725                 730                 735     


Leu Ala Asn Asp Asn Ala Val Asp Pro Arg Ser Phe Ser Gln Asn Ser 
            740                 745                 750         


Asn His Leu His Ser Arg Lys Lys Lys Ser Asn Thr Pro Met Arg Phe 
        755                 760                 765             


Pro Leu Ser His Pro Thr Gln His Gly Ser Phe Trp Ser Asp Ser Gln 
    770                 775                 780                 


Gly Asp Val His Asp Ala Val His Arg Ala His Ser Pro Ala Ala Ala 
785                 790                 795                 800 


His Ser Asn Glu Gly Pro Ala Glu Ala Ala Gln Leu Glu Pro Lys Pro 
                805                 810                 815     


His Pro Gly Glu Lys Met Ala Leu Pro Pro Ser Trp Leu Arg Ala Lys 
            820                 825                 830         


Arg Ser Leu Val Thr Thr Met Glu Ala Lys Arg Lys Lys Leu Asp Leu 
        835                 840                 845             


Gln Val Gln Val Ser Gly Leu Pro Asp Asp Arg Thr Thr Ala Val Val 
    850                 855                 860                 


Ala Pro Asp Asp Pro Met Ala Ala Cys Lys Lys Ala Gly Ser Ser Gly 
865                 870                 875                 880 


Phe Pro Asp Glu Ser Ser Pro Ala Ala Leu Gly Lys Lys Met Tyr Pro 
                885                 890                 895     


Arg Ile Arg Pro His Gly Pro Leu Ser Ile Ile Glu Gly Asn Arg Asp 
            900                 905                 910         


Ser Asn Ser Ser Asp Ser Thr Leu Met Tyr Arg Leu Gly Ser Pro Pro 
        915                 920                 925             


Gly Asp Ala Thr Ser Trp Thr Glu Asn Arg Arg Gly Leu Gly Glu Lys 
    930                 935                 940                 


Arg Ser His Arg Val Ala Phe Leu Ala Arg Gly Asn Thr Leu Leu Ser 
945                 950                 955                 960 


Asp Val Asp Glu Lys Ser His Ala Pro Gly Pro Thr Ser Val Gly Asn 
                965                 970                 975     


Ser Thr Ala Ala Met Gln Asp Thr Ile Leu Glu Ile Cys Ser Glu Ile 
            980                 985                 990         


Leu Glu Val Thr Pro Pro Ile His  Asp Arg Ile Leu Ser  Asp Lys Ser 
        995                 1000                 1005             


Ala Thr  Tyr Leu Arg Pro His  Arg Thr Pro Asp Arg  Ile Thr Ser 
    1010                 1015                 1020             


Thr Glu  Arg Lys Asp Ile Arg  His Glu Lys Asp Gly  Asp Leu Val 
    1025                 1030                 1035             


Pro Gln  Asp Ala Asp Asp Thr  Ser Ala Pro Phe Ser  Glu Ala Pro 
    1040                 1045                 1050             


Phe Leu  Ser Glu Ser Thr Asp  Trp Leu Lys Glu Ala  Asn Gly Asp 
    1055                 1060                 1065             


Asn Ser  Ala Lys Pro Glu Gln  Glu Pro Ser Pro Glu  Gln Leu Val 
    1070                 1075                 1080             


Tyr Leu  Met Tyr Ile Lys Cys  Met Glu Asn Gln Ser  Phe Ser Ser 
    1085                 1090                 1095             


Glu Lys  Asn Lys Met Ile Ala  Gly Gln Gly Gly Phe  Thr Lys Asn 
    1100                 1105                 1110             


Thr Gly  Leu Glu Asp Thr Val  Phe Pro Arg Lys Thr  Ser Val Phe 
    1115                 1120                 1125             


Leu Thr  Thr Val Ala Lys Arg  Gln Glu Ser Gly Arg  His Asn Gln 
    1130                 1135                 1140             


Glu Asn  Ile Pro Gln Ala Val  Thr Glu Lys Glu Ala  Pro Ile Glu 
    1145                 1150                 1155             


Glu Lys  Gly Ala Leu Pro Gln  Val His Ile Ala Thr  Gly Ser Lys 
    1160                 1165                 1170             


Asn Phe  Pro Arg Asp Met Phe  Val Leu Gly Thr Gly  Gln Asn Ile 
    1175                 1180                 1185             


Asn Leu  His Glu Glu Thr Tyr  Val Pro Val His Lys  Asn Val Pro 
    1190                 1195                 1200             


Trp Thr  Arg Asn Pro Thr Asp  Thr Arg Gln Ile Pro  Met Val His 
    1205                 1210                 1215             


Phe Phe  Lys Lys Arg Lys Glu  Glu Glu Thr Asn Ser  Gly Gly Leu 
    1220                 1225                 1230             


Val Asn  Lys Thr Arg Glu Met  Val Arg Asn Tyr Pro  Ser Gln Lys 
    1235                 1240                 1245             


Asn Ser  Val Ala Arg Arg Arg  Glu Gln Ala Ser Gly  Arg Ile Lys 
    1250                 1255                 1260             


Ala Ser  Ala Arg Trp Leu Pro  Asp Val Asn Arg Ser  Ile Gln Ser 
    1265                 1270                 1275             


Leu Leu  Lys Gln Ile Asp His  Arg Lys Glu Arg Lys  Lys Phe Ile 
    1280                 1285                 1290             


Ile Glu  Ser Arg Ser Ala Asp  Pro Ser Gly Thr Lys  Ser Pro Thr 
    1295                 1300                 1305             


Gln Thr  Asn His Ser Pro Ser  His Val Val Lys Thr  Ser Ala Phe 
    1310                 1315                 1320             


Pro Pro  Arg Asp Ile Arg Arg  Ile Glu Ser Arg Asp  Ser Ser Gln 
    1325                 1330                 1335             


Val Trp  Val Ser Ser Tyr Ala  Tyr Asp Phe Glu Ala  Gly Ser Ser 
    1340                 1345                 1350             


Arg Ile  Arg Glu Ser Ser Pro  Phe Leu Asn Glu Thr  Glu Thr Asp 
    1355                 1360                 1365             


Asn Pro  Ser Leu Ala Val Pro  Pro Arg Glu Arg Phe  Val Arg Arg 
    1370                 1375                 1380             


Gly Arg  Phe Ala Ser Pro Gly  Lys Val Asn Thr His  Ser Val Pro 
    1385                 1390                 1395             


Phe Met  His Arg Gly Arg Phe  Thr Ser Pro Glu Lys  Val Asn Thr 
    1400                 1405                 1410             


His Ser  Ala Pro Cys Asp Lys  Pro Glu Asn Val Val  Ser Ser Glu 
    1415                 1420                 1425             


Pro Val  Ser Pro Gly Glu Ala  Val Thr Val Ala Leu  Pro Pro His 
    1430                 1435                 1440             


Val Ser  Thr Gln Glu Glu Glu  Pro Leu Pro Ala Gly  Ser Ser Cys 
    1445                 1450                 1455             


Glu Arg  Arg Gly His Val Asp  Leu Phe Leu Glu Ile  Ser Leu Gln 
    1460                 1465                 1470             


Arg Thr  Arg Gly Pro Val Glu  Gln Ser Arg Gly Arg  Arg Ser Gly 
    1475                 1480                 1485             


Gly Asp  Thr Glu Gly His Thr  Glu Asn Pro Gly Lys  Thr Pro Ser 
    1490                 1495                 1500             


Pro Leu  Pro Gln Met Pro Lys  Asp Gln Arg Gly Ser  Glu Ala Gly 
    1505                 1510                 1515             


Tyr Pro  Lys Ile Cys Arg Trp  Arg Asp Gly Thr Val  Leu Pro Pro 
    1520                 1525                 1530             


Arg Pro  His Asn Leu Ser Leu  Gly Ala Lys Lys Lys  Pro Asn Leu 
    1535                 1540                 1545             


Pro Arg  Arg Glu Ala Thr Arg  Val Glu Gln Gly Glu  Ala Leu Ser 
    1550                 1555                 1560             


Leu Val  Ser Pro Glu Pro Leu  Val Leu Arg Arg Arg  Pro Arg Glu 
    1565                 1570                 1575             


Ser Ser  Thr Leu Leu Pro Gly  Gly Glu Met Arg Glu  Asp Asp Gly 
    1580                 1585                 1590             


Asp Gly  Val Thr Ala Glu Tyr  Asp Asp Asp Asp Asp  Val Met Ala 
    1595                 1600                 1605             


Glu Tyr  Asp Asp Asp Ala Val  Thr Val His Thr Pro  Glu Asp Phe 
    1610                 1615                 1620             


Asp Ile  Tyr Gly Glu Glu Ala  Gly Gln Gly Pro Arg  Gly Phe Gln 
    1625                 1630                 1635             


Gln Lys  Thr Arg His Tyr Phe  Ile Ala Ala Val Glu  Glu Leu Trp 
    1640                 1645                 1650             


Asp Tyr  Gly Val Arg Val Ser  Pro Gly Ala Pro Gly  Asp Arg Ala 
    1655                 1660                 1665             


Trp Ser  Gly Asp Ala Ala Arg  Phe Arg Lys Val Val  Phe Arg Glu 
    1670                 1675                 1680             


Phe Thr  Asp Gly Ser Phe Thr  Gln Arg Val His Arg  Gly Glu Leu 
    1685                 1690                 1695             


Asp Ala  His Leu Gly Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val 
    1700                 1705                 1710             


Glu Asp  Asn Ile Val Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro 
    1715                 1720                 1725             


Tyr Ser  Phe Tyr Ser Ser Leu  Val Ser Tyr Pro Glu  Ala Asp Gly 
    1730                 1735                 1740             


Gly Ala  Ala Pro Arg Ser Asn  Phe Val Arg Pro Asn  Glu Thr Lys 
    1745                 1750                 1755             


Thr Tyr  Phe Trp Arg Val Arg  Pro His Met Ala Pro  Thr Asp Gly 
    1760                 1765                 1770             


Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu 
    1775                 1780                 1785             


Glu Arg  Asp Leu His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
    1790                 1795                 1800             


His Ala  Ser Thr Leu His Pro  Ser His Ala Arg Pro  Leu Ala Val 
    1805                 1810                 1815             


Gln Glu  Phe Ala Leu Leu Phe  Ala Val Phe Asp Glu  Thr Lys Ser 
    1820                 1825                 1830             


Trp Tyr  Cys Ala Glu Asn Leu  Asp Arg Lys Cys Arg  Pro Pro Arg 
    1835                 1840                 1845             


Gly Thr  Pro Ala Gly Asp Pro  Ala Trp Arg Glu Glu  Tyr Arg Phe 
    1850                 1855                 1860             


His Ala  Val Asn Gly Tyr Val  Ala Asp Ala Leu Leu  Gly Leu Val 
    1865                 1870                 1875             


Met Ala  Glu Gly Arg Arg Thr  Arg Trp His Leu Leu  Ser Met Gly 
    1880                 1885                 1890             


Asp Pro  Gly His Ala Gln Ser  Val His Phe Ser Ala  His Ser Val 
    1895                 1900                 1905             


Thr Val  Arg Asp Gly Gly Glu  His Arg Thr Ala Val  Cys Asn Leu 
    1910                 1915                 1920             


Tyr Pro  Gly Val Phe Thr Thr  Val Glu Met Leu Pro  Ser Arg Ala 
    1925                 1930                 1935             


Gly Ile  Trp Arg Val Glu Ser  Leu Val Gly Glu His  Leu Arg Ala 
    1940                 1945                 1950             


Gly Met  Ser Ala Leu Phe Leu  Val Tyr Ser Thr Arg  Cys Gln Val 
    1955                 1960                 1965             


Pro Leu  Gly Met Ala Ser Gly  Tyr Ile Arg Asp Ser  Gln Ile Thr 
    1970                 1975                 1980             


Ala Ser  Gly Tyr His Gly Leu  Trp Thr Pro Gln Leu  Ala Arg Leu 
    1985                 1990                 1995             


His Asn  Ala Gly Ser Val Asn  Ala Trp Ser Ala Lys  Glu Pro Phe 
    2000                 2005                 2010             


Ala Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Leu His Gly 
    2015                 2020                 2025             


Ile Glu  Thr Gln Gly Ala Arg  His Arg Leu Ser Ser  Leu Tyr Val 
    2030                 2035                 2040             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Gln Trp Leu 
    2045                 2050                 2055             


Ser Tyr  Arg Gly Asn Ser Thr  Gly Ser Leu Met Val  Phe Phe Gly 
    2060                 2065                 2070             


Asn Val  Asp Ala Ser Thr Val  Arg His Asn Arg Phe  Asp Pro Pro 
    2075                 2080                 2085             


Ile Val  Ala Arg Tyr Ile Arg  Val His Pro Thr His  Ala Ser Ile 
    2090                 2095                 2100             


Arg Thr  Ala Leu Arg Met Glu  Leu Leu Gly Cys Asp  Leu Asn Ser 
    2105                 2110                 2115             


Cys Ser  Ala Pro Leu Gly Met  Glu Ser Gly Trp Ile  Ser Asp Thr 
    2120                 2125                 2130             


Gln Val  Thr Ala Ser Ser His  Leu Ser Thr Thr Phe  Ser Ala Trp 
    2135                 2140                 2145             


Leu Pro  Ala Leu Ala Arg Leu  His Leu Arg Gly Gly  Ala Asn Ala 
    2150                 2155                 2160             


Trp Arg  Pro Gln Val Asn Asp  Pro Thr Gln Trp Leu  Gln Val Asp 
    2165                 2170                 2175             


Leu Gln  Arg Thr Val Lys Val  Thr Gly Val Val Thr  Gln Gly Ala 
    2180                 2185                 2190             


Arg Ser  Leu Leu Thr Ala Met  Phe Val Lys Lys Phe  Leu Val Ser 
    2195                 2200                 2205             


Thr Ser  Gln Asp Gly Arg His  Trp Thr His Val Leu  Gln Asp Gly 
    2210                 2215                 2220             


Lys Val  Lys Val Phe Gln Gly  Asn Arg Asp Ala Ser  Thr Pro Met 
    2225                 2230                 2235             


Val Asn  Ser Leu His Pro Pro  Arg Phe Thr Arg Tyr  Leu Arg Ile 
    2240                 2245                 2250             


His Pro  Gln Val Trp Glu Arg  Gln Ile Ala Leu Arg  Leu Glu Ile 
    2255                 2260                 2265             


Leu Gly  Cys Glu Ala Gln Gln  Leu Asp 
    2270                 2275         


<210>  80
<211>  2277
<212>  PRT
<213>  Rattus norvegicus

<400>  80

Met Arg Ala Ala Arg Gly Leu Cys Phe Phe Leu Ser Leu Cys Ala Leu 
1               5                   10                  15      


Cys Ser Cys Ala Thr Arg Lys Tyr Tyr Leu Gly Ala Val Glu Leu Pro 
            20                  25                  30          


Trp Asp Tyr Val Ser Gly Gly Ala Ser Gly Ala Gln Arg Ser Asp Ser 
        35                  40                  45              


Arg Phe Pro Pro Gly Thr Pro Ala Pro Ser Ala His Val Val His Thr 
    50                  55                  60                  


Lys Thr Val Phe Val Glu Tyr Met Asp Arg Phe Phe His Thr Ala Lys 
65                  70                  75                  80  


Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Trp Thr Glu 
                85                  90                  95      


Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
            100                 105                 110         


Val Ser Leu His Ala Val Gly Met Ser Phe Trp Lys Ala Ser Glu Gly 
        115                 120                 125             


Ala Ala Tyr Asp Asp His Ser Ser Pro Ala Glu Lys Asp Asp Asp Lys 
    130                 135                 140                 


Val Leu Pro Gly Glu Ser His Thr Tyr Ala Trp Gln Val Leu Gly Glu 
145                 150                 155                 160 


Ser Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ala Tyr Leu 
                165                 170                 175     


Ser His Val Asp Leu Val Arg Asp Leu Asn Ser Gly Leu Val Gly Ala 
            180                 185                 190         


Pro Leu Val Cys Lys Glu Gly Arg Leu Ser Ala Asp Arg Thr Arg Met 
        195                 200                 205             


Pro Pro His Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Arg Ser 
    210                 215                 220                 


Trp His Ala Ala Thr Arg Asp Pro Ala Ser Thr Glu Ala Gln Pro Thr 
225                 230                 235                 240 


Val His Thr Val Asn Gly Tyr Thr Asn Arg Thr Leu Pro Gly Leu Thr 
                245                 250                 255     


Gly Cys Arg Gly Thr Ser Val Tyr Trp His Val Met Ala Val Gly Thr 
            260                 265                 270         


Thr Pro Asp Ile His Ser Ile Leu Leu Glu Gly His Thr Phe Ser Val 
        275                 280                 285             


Arg Ser His Arg Gln Ala Ser Leu Glu Ile Ser Pro Met Thr Leu Leu 
    290                 295                 300                 


Thr Ala Gln Thr Trp Leu Met Asp Leu Gly Arg Phe Leu Leu Phe Cys 
305                 310                 315                 320 


His Ile Ser Ser His Arg His Gly Gly Met Glu Ala Tyr Val Gln Val 
                325                 330                 335     


Asp Asn Cys Pro Glu Ala Pro Gln Gly Gln Gly Lys Arg Asp Glu Asp 
            340                 345                 350         


Thr Glu Asp Tyr Asp Asp Leu Asp Ser Glu Met Asp Val Phe Thr Trp 
        355                 360                 365             


Asp Pro Asp Ala Ala Pro Phe Val Gln Val Arg Ser Ala Ala Lys Arg 
    370                 375                 380                 


His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Gly Asp Trp 
385                 390                 395                 400 


Asp Tyr Ala Pro Ala Ala Ala Thr Leu Glu Asp Gly Ser Leu Arg Asn 
                405                 410                 415     


Arg Tyr Leu Gly Arg Gly Pro Gly Arg Ile Gly Ser Lys Tyr Lys Lys 
            420                 425                 430         


Val Arg Phe Val Ala Tyr Thr Asp Gly Thr Phe His Thr Arg Glu Ala 
        435                 440                 445             


Thr Pro Arg Glu Ala Gly Leu Leu Gly Pro Leu Leu Tyr Gly Glu Val 
    450                 455                 460                 


Gly Asp Ser Leu Leu Ile Val Phe Lys Asn Arg Ala Ser Arg Ala Tyr 
465                 470                 475                 480 


Asn Ile His Pro His Gly Ile Arg Asp Val Gly Ala Val His Ala Gly 
                485                 490                 495     


Arg Leu Pro Arg Gly Val Lys His Val Lys Asp Leu Pro Ile Arg Pro 
            500                 505                 510         


Gly Glu Thr Phe Lys Tyr Arg Trp Thr Leu Thr Ala Glu Asp Gly Pro 
        515                 520                 525             


Ala Arg Ser Asp Ala Arg Cys Val Thr Arg Tyr Tyr Ala Ser Ala Val 
    530                 535                 540                 


Asp Pro Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile 
545                 550                 555                 560 


Cys Cys Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp 
                565                 570                 575     


Glu Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp 
            580                 585                 590         


Tyr Ile Ser Glu Asn Met Arg Arg Phe Leu Pro Asp Glu Ala His Val 
        595                 600                 605             


Gln Leu Gln Asp Pro Glu Phe Glu Ala Ser Asn Leu Met His Ser Ile 
    610                 615                 620                 


Asn Gly Tyr Val Phe Asp Gly Leu Glu Leu Arg Val Cys Leu His Glu 
625                 630                 635                 640 


Val Ala Ala Trp His Val Leu Ser Val Gly Ala Gln Thr Asp Phe Leu 
                645                 650                 655     


Ser Val Phe Phe Ser Gly His Thr Phe Arg His Arg Ala Val Tyr Ala 
            660                 665                 670         


Asp Thr Leu Thr Val Phe Pro His Ser Gly Val Thr Val Phe Met Ser 
        675                 680                 685             


Met Asp Asn Pro Gly Val Trp Val Leu Gly Cys His Asn Pro Asp Phe 
    690                 695                 700                 


Arg Glu Ser Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Glu 
705                 710                 715                 720 


Gly Val Ser Asp Tyr Tyr Gly Glu Thr Tyr Glu Gly Val Leu Ala Pro 
                725                 730                 735     


Leu Ala Asn Asp Asn Ala Val Asp Pro Arg Ser Phe Ser Gln Asn Ser 
            740                 745                 750         


Asn His Leu His Ser Arg Lys Lys Lys Ser Asn Thr Pro Met Arg Phe 
        755                 760                 765             


Pro Leu Ser His Pro Thr Gln His Gly Ser Phe Trp Ser Asp Ser Gln 
    770                 775                 780                 


Gly Asp Val His Asp Ala Val His Arg Ala His Ser Pro Ala Ala Ala 
785                 790                 795                 800 


His Ser Asn Glu Gly Pro Ala Glu Ala Ala Gln Leu Glu Pro Lys Pro 
                805                 810                 815     


His Pro Gly Glu Lys Met Ala Leu Pro Pro Ser Trp Leu Arg Ala Lys 
            820                 825                 830         


Arg Ser Leu Val Thr Thr Met Glu Ala Lys Arg Lys Lys Leu Asp Leu 
        835                 840                 845             


Gln Val Gln Val Ser Gly Leu Pro Asp Asp Arg Thr Thr Ala Val Val 
    850                 855                 860                 


Ala Pro Asp Asp Pro Met Ala Ala Cys Lys Lys Ala Gly Ser Ser Gly 
865                 870                 875                 880 


Phe Pro Asp Glu Ser Ser Pro Ala Ala Leu Gly Lys Lys Met Tyr Pro 
                885                 890                 895     


Arg Ile Arg Pro His Gly Pro Leu Ser Ile Ile Glu Gly Asn Arg Asp 
            900                 905                 910         


Ser Asn Ser Ser Asp Ser Thr Leu Met Tyr Arg Leu Gly Ser Pro Pro 
        915                 920                 925             


Gly Asp Ala Thr Ser Trp Thr Glu Asn Arg Arg Gly Leu Gly Glu Lys 
    930                 935                 940                 


Arg Ser His Arg Val Ala Phe Leu Ala Arg Gly Asn Thr Leu Leu Ser 
945                 950                 955                 960 


Asp Val Asp Glu Lys Ser His Ala Pro Gly Pro Thr Ser Val Gly Asn 
                965                 970                 975     


Ser Thr Ala Ala Met Gln Asp Thr Ile Leu Glu Ile Cys Ser Glu Ile 
            980                 985                 990         


Leu Glu Val Thr Pro Pro Ile His  Asp Arg Ile Leu Ser  Asp Lys Ser 
        995                 1000                 1005             


Ala Thr  Tyr Leu Arg Pro His  Arg Thr Pro Asp Arg  Ile Thr Ser 
    1010                 1015                 1020             


Thr Glu  Arg Lys Asp Ile Arg  His Glu Lys Asp Gly  Asp Leu Val 
    1025                 1030                 1035             


Pro Gln  Asp Ala Asp Asp Thr  Ser Ala Pro Phe Ser  Glu Ala Pro 
    1040                 1045                 1050             


Phe Leu  Ser Glu Ser Thr Asp  Trp Leu Lys Glu Ala  Asn Gly Asp 
    1055                 1060                 1065             


Asn Ser  Ala Lys Pro Glu Gln  Glu Pro Ser Pro Glu  Gln Leu Val 
    1070                 1075                 1080             


Tyr Leu  Met Tyr Ile Lys Cys  Met Glu Asn Gln Ser  Phe Ser Ser 
    1085                 1090                 1095             


Glu Lys  Asn Lys Met Ile Ala  Gly Gln Gly Gly Phe  Thr Lys Asn 
    1100                 1105                 1110             


Thr Gly  Leu Glu Asp Thr Val  Phe Pro Arg Lys Thr  Ser Val Phe 
    1115                 1120                 1125             


Leu Thr  Thr Val Ala Lys Arg  Gln Glu Ser Gly Arg  His Asn Gln 
    1130                 1135                 1140             


Glu Asn  Ile Pro Gln Ala Val  Thr Glu Lys Glu Ala  Pro Ile Glu 
    1145                 1150                 1155             


Glu Lys  Gly Ala Leu Pro Gln  Val His Ile Ala Thr  Gly Ser Lys 
    1160                 1165                 1170             


Asn Phe  Pro Arg Asp Met Phe  Val Leu Gly Thr Gly  Gln Asn Ile 
    1175                 1180                 1185             


Asn Leu  His Glu Glu Thr Tyr  Val Pro Val His Lys  Asn Val Pro 
    1190                 1195                 1200             


Trp Thr  Arg Asn Pro Thr Asp  Thr Arg Gln Ile Pro  Met Val His 
    1205                 1210                 1215             


Phe Phe  Lys Lys Arg Lys Glu  Glu Glu Thr Asn Ser  Gly Gly Leu 
    1220                 1225                 1230             


Val Asn  Lys Thr Arg Glu Met  Val Arg Asn Tyr Pro  Ser Gln Lys 
    1235                 1240                 1245             


Asn Ser  Val Ala Arg Arg Arg  Glu Gln Ala Ser Gly  Arg Ile Lys 
    1250                 1255                 1260             


Ala Ser  Ala Arg Trp Leu Pro  Asp Val Asn Arg Ser  Ile Gln Ser 
    1265                 1270                 1275             


Leu Leu  Lys Gln Ile Asp His  Arg Lys Glu Arg Lys  Lys Phe Ile 
    1280                 1285                 1290             


Ile Glu  Ser Arg Ser Ala Asp  Pro Ser Gly Thr Lys  Ser Pro Thr 
    1295                 1300                 1305             


Gln Thr  Asn His Ser Pro Ser  His Val Val Lys Thr  Ser Ala Phe 
    1310                 1315                 1320             


Pro Pro  Arg Asp Ile Arg Arg  Ile Glu Ser Arg Asp  Ser Ser Gln 
    1325                 1330                 1335             


Val Trp  Val Ser Ser Tyr Ala  Tyr Asp Phe Glu Ala  Gly Ser Ser 
    1340                 1345                 1350             


Arg Ile  Arg Glu Ser Ser Pro  Phe Leu Asn Glu Thr  Glu Thr Asp 
    1355                 1360                 1365             


Asn Pro  Ser Leu Ala Val Pro  Pro Arg Glu Arg Phe  Val Arg Arg 
    1370                 1375                 1380             


Gly Arg  Phe Ala Ser Pro Gly  Lys Val Asn Thr His  Ser Val Pro 
    1385                 1390                 1395             


Phe Met  His Arg Gly Arg Phe  Thr Ser Pro Glu Lys  Val Asn Thr 
    1400                 1405                 1410             


His Ser  Ala Pro Cys Asp Lys  Pro Glu Asn Val Val  Ser Ser Glu 
    1415                 1420                 1425             


Pro Val  Ser Pro Gly Glu Ala  Val Thr Val Ala Leu  Pro Pro His 
    1430                 1435                 1440             


Val Ser  Thr Gln Glu Glu Glu  Pro Leu Pro Ala Gly  Ser Ser Cys 
    1445                 1450                 1455             


Glu Arg  Arg Gly His Val Asp  Leu Phe Leu Glu Ile  Ser Leu Gln 
    1460                 1465                 1470             


Arg Thr  Arg Gly Pro Val Glu  Gln Ser Arg Gly Arg  Arg Ser Gly 
    1475                 1480                 1485             


Gly Asp  Thr Glu Gly His Thr  Glu Asn Pro Gly Lys  Thr Pro Ser 
    1490                 1495                 1500             


Pro Leu  Pro Gln Met Pro Lys  Asp Gln Arg Gly Ser  Glu Ala Gly 
    1505                 1510                 1515             


Tyr Pro  Lys Ile Cys Arg Trp  Arg Asp Gly Thr Val  Leu Pro Pro 
    1520                 1525                 1530             


Arg Pro  His Asn Leu Ser Leu  Gly Ala Lys Lys Lys  Pro Asn Leu 
    1535                 1540                 1545             


Pro Arg  Arg Glu Ala Thr Arg  Val Glu Gln Gly Glu  Ala Leu Ser 
    1550                 1555                 1560             


Leu Val  Ser Pro Glu Pro Leu  Val Leu Arg Arg Arg  Pro Arg Glu 
    1565                 1570                 1575             


Ser Ser  Thr Leu Leu Pro Gly  Gly Glu Met Arg Glu  Asp Asp Gly 
    1580                 1585                 1590             


Asp Gly  Val Thr Ala Glu Tyr  Asp Asp Asp Asp Asp  Val Met Ala 
    1595                 1600                 1605             


Glu Tyr  Asp Asp Asp Ala Val  Thr Val His Thr Pro  Glu Asp Phe 
    1610                 1615                 1620             


Asp Ile  Tyr Gly Glu Glu Ala  Gly Gln Gly Pro Arg  Gly Phe Gln 
    1625                 1630                 1635             


Gln Lys  Thr Arg His Tyr Phe  Ile Ala Ala Val Glu  Glu Leu Trp 
    1640                 1645                 1650             


Asp Tyr  Gly Val Arg Val Ser  Pro Gly Ala Pro Gly  Asp Arg Ala 
    1655                 1660                 1665             


Trp Ser  Gly Asp Ala Ala Arg  Phe Arg Lys Val Val  Phe Arg Glu 
    1670                 1675                 1680             


Phe Thr  Asp Gly Ser Phe Thr  Gln Arg Val His Arg  Gly Glu Leu 
    1685                 1690                 1695             


Asp Ala  His Leu Gly Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val 
    1700                 1705                 1710             


Glu Asp  Asn Ile Val Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro 
    1715                 1720                 1725             


Tyr Ser  Phe Tyr Ser Ser Leu  Val Ser Tyr Pro Glu  Ala Asp Gly 
    1730                 1735                 1740             


Gly Ala  Ala Pro Arg Ser Asn  Phe Val Arg Pro Asn  Glu Thr Lys 
    1745                 1750                 1755             


Thr Tyr  Phe Trp Arg Val Arg  Pro His Met Ala Pro  Thr Asp Gly 
    1760                 1765                 1770             


Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu 
    1775                 1780                 1785             


Glu Arg  Asp Leu His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
    1790                 1795                 1800             


His Ala  Ser Thr Leu His Pro  Ser His Ala Arg Pro  Leu Ala Val 
    1805                 1810                 1815             


Gln Glu  Phe Ala Leu Leu Phe  Ala Val Phe Asp Glu  Thr Lys Ser 
    1820                 1825                 1830             


Trp Tyr  Cys Ala Glu Asn Leu  Asp Arg Lys Cys Arg  Pro Pro Arg 
    1835                 1840                 1845             


Gly Thr  Pro Ala Gly Asp Pro  Ala Trp Arg Glu Glu  Tyr Arg Phe 
    1850                 1855                 1860             


His Ala  Val Asn Gly Tyr Val  Ala Asp Ala Leu Leu  Gly Leu Val 
    1865                 1870                 1875             


Met Ala  Glu Gly Arg Arg Thr  Arg Trp His Leu Leu  Ser Met Gly 
    1880                 1885                 1890             


Asp Pro  Gly His Ala Gln Ser  Val His Phe Ser Ala  His Ser Val 
    1895                 1900                 1905             


Thr Val  Arg Asp Gly Gly Glu  His Arg Thr Ala Val  Cys Asn Leu 
    1910                 1915                 1920             


Tyr Pro  Gly Val Phe Thr Thr  Val Glu Met Leu Pro  Ser Arg Ala 
    1925                 1930                 1935             


Gly Ile  Trp Arg Val Glu Ser  Leu Val Gly Glu His  Leu Arg Ala 
    1940                 1945                 1950             


Gly Met  Ser Ala Leu Phe Leu  Val Tyr Ser Thr Arg  Cys Gln Val 
    1955                 1960                 1965             


Pro Leu  Gly Met Ala Ser Gly  Tyr Ile Arg Asp Ser  Gln Ile Thr 
    1970                 1975                 1980             


Ala Ser  Gly Tyr His Gly Leu  Trp Thr Pro Gln Leu  Ala Arg Leu 
    1985                 1990                 1995             


His Asn  Ala Gly Ser Val Asn  Ala Trp Ser Ala Lys  Glu Pro Phe 
    2000                 2005                 2010             


Ala Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Leu His Gly 
    2015                 2020                 2025             


Ile Glu  Thr Gln Gly Ala Arg  His Arg Leu Ser Ser  Leu Tyr Val 
    2030                 2035                 2040             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Gln Trp Leu 
    2045                 2050                 2055             


Ser Tyr  Arg Gly Asn Ser Thr  Gly Ser Leu Met Val  Phe Phe Gly 
    2060                 2065                 2070             


Asn Val  Asp Ala Ser Thr Val  Arg His Asn Arg Phe  Asp Pro Pro 
    2075                 2080                 2085             


Ile Val  Ala Arg Tyr Ile Arg  Val His Pro Thr His  Ala Ser Ile 
    2090                 2095                 2100             


Arg Thr  Ala Leu Arg Met Glu  Leu Leu Gly Cys Asp  Leu Asn Ser 
    2105                 2110                 2115             


Cys Ser  Ala Pro Leu Gly Met  Glu Ser Gly Trp Ile  Ser Asp Thr 
    2120                 2125                 2130             


Gln Val  Thr Ala Ser Ser His  Leu Ser Thr Thr Phe  Ser Ala Trp 
    2135                 2140                 2145             


Leu Pro  Ala Leu Ala Arg Leu  His Leu Arg Gly Gly  Ala Asn Ala 
    2150                 2155                 2160             


Trp Arg  Pro Gln Val Asn Asp  Pro Thr Gln Trp Leu  Gln Val Asp 
    2165                 2170                 2175             


Leu Gln  Arg Thr Val Lys Val  Thr Gly Val Val Thr  Gln Gly Ala 
    2180                 2185                 2190             


Arg Ser  Leu Leu Thr Ala Met  Phe Val Lys Lys Phe  Leu Val Ser 
    2195                 2200                 2205             


Thr Ser  Gln Asp Gly Arg His  Trp Thr His Val Leu  Gln Asp Gly 
    2210                 2215                 2220             


Lys Val  Lys Val Phe Gln Gly  Asn Arg Asp Ala Ser  Thr Pro Met 
    2225                 2230                 2235             


Val Asn  Ser Leu His Pro Pro  Arg Phe Thr Arg Tyr  Leu Arg Ile 
    2240                 2245                 2250             


His Pro  Gln Val Trp Glu Arg  Gln Ile Ala Leu Arg  Leu Glu Ile 
    2255                 2260                 2265             


Leu Gly  Cys Glu Ala Gln Gln  Leu Asp 
    2270                 2275         


<210>  81
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-1 artificial insertion construct

<400>  81

Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser Lys Ala Pro 
1               5                   10                  15      


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
            20                  25                  30          


Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser 
        35                  40                  45  


<210>  82
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-1 artificial insertion construct

<400>  82
ggcgcgccgg gaggcggagg aagcgactcc agcagcagca aggcccctcc ccctagcctg       60

cctagcccta gcaggctgcc tggacctagc gataccccca ttctgcctca gggcggcgga      120

ggcagcgcct cgag                                                        134


<210>  83
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin-binding peptide ABP1 artificial insertion construct

<400>  83

Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Leu Ile 
1               5                   10                  15      


Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser 
        35                  40                  


<210>  84
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Albumin-binding peptide ABP1 artificial insertion construct

<400>  84
ggcgcgccgg gcggaggagg ctccggagga ggcggaagca ggctgatcga ggacatctgc       60

ctgcccaggt ggggctgtct gtgggaagat gacggaggcg gcggaagcgg aggcggagga      120

agcgcctcga g                                                           131


<210>  85
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-Ser repeat (HAP1) artificial insertion construct

<400>  85

Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ser 
        35                  40      


<210>  86
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gly-Ser repeat (HAP1) artificial insertion construct

<400>  86
ggcgcgccgg gaggaggcgg ctccggcgga ggaggaagcg gcggaggagg cagcggaggc       60

ggcggctccg gcggcggcgg cagcggcggc ggaggcagcg gaggcggcgg cagcgcctcg      120

ag                                                                     122


<210>  87
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enhanced GFP (EGFPP1) artificial insertion construct

<400>  87

Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Val Ser 
1               5                   10                  15      


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            20                  25                  30          


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        35                  40                  45              


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    50                  55                  60                  


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
65                  70                  75                  80  


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
                85                  90                  95      


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            100                 105                 110         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        115                 120                 125             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    130                 135                 140                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
145                 150                 155                 160 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                165                 170                 175     


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
            180                 185                 190         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
        195                 200                 205             


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
    210                 215                 220                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
225                 230                 235                 240 


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ala Ser Ser 
            260                 265 


<210>  88
<211>  239
<212>  PRT
<213>  Unknown

<220>
<223>  Enhanced GFP (EGFPP1)

<400>  88

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  89
<211>  794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhanced GFP (EGFPP1) artificial insertion construct

<400>  89
ggcgcgccgg gcggaggagg aagcggaggc ggaggctcca tggtgagcaa gggcgaagag       60

ctgttcaccg gcgtggtgcc catcctcgtg gaactggacg gcgatgtcaa cggccacaag      120

ttcagcgtca gcggagaggg agaaggcgac gccacctacg gcaagctcac cctgaagttc      180

atctgtacca ccggcaagct gcctgtgccc tggcctacac tggtgaccac cctgacctat      240

ggagtgcagt gctttagcag gtaccccgac cacatgaagc agcacgactt tttcaagagc      300

gccatgcctg aaggctacgt gcaggagagg accatcttct tcaaagacga cggcaactac      360

aagaccaggg ccgaggtcaa gttcgagggc gataccctcg tgaacaggat cgagctgaag      420

ggaatcgact tcaaggagga cggcaacatc ctgggccaca agctggagta caattacaac      480

tcccacaacg tgtatatcat ggccgataaa cagaagaatg gaatcaaagt caatttcaag      540

atcaggcaca atatcgagga cggcagcgtc caactggccg accactatca gcagaatacc      600

cccattggag acggacccgt gctgctcccc gacaaccact acctctccac acagtccgct      660

ctgtccaagg accccaacga gaagagggac catatggtcc tgctggaatt cgtgaccgcc      720

gctggcatca ccctcggcat ggatgagctg tacaagggag gaggaggcag cggaggaggc      780

ggaagcgcct cgag                                                        794


<210>  90
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-Ser repeat sequence containing a single Cys residue (CCP1) 
       artificial insertion construct

<400>  90

Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Cys Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ser 
        35                  40      


<210>  91
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gly-Ser repeat sequence containing a single Cys residue (CCP1) 
       artificial insertion construct

<400>  91
ggcgcgccgg gaggaggcgg ctccggcgga ggaggaagcg gcggaggagg cagcggaggc       60

tgcggctccg gcggcggcgg cagcggcggc ggaggcagcg gaggcggcgg cagcgcctcg      120

ag                                                                     122


<210>  92
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0018-CTP1  DNA SEQUENCE

<400>  92
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaggcgcg       60

ccgggaggcg gaggaagcga ctccagcagc agcaaggccc ctccccctag cctgcctagc      120

cctagcaggc tgcctggacc tagcgatacc cccattctgc ctcagggcgg cggaggcagc      180

gcctcgagca gtgatctcgg tgagctgcct gtggacgcaa gatttcctcc tagagtgcca      240

aaatcttttc cattcaacac ctcagtcgtg tacaaaaaga ctctgtttgt agaattcacg      300

gatcaccttt tcaacatcgc taagccaagg ccaccctgga tgggtctgct aggtcctacc      360

atccaggctg aggtttatga tacagtggtc attacactta agaacatggc ttcccatcct      420

gtcagtcttc atgctgttgg tgtatcctac tggaaagctt ctgagggagc tgaatatgat      480

gatcagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca      540

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc      600

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc      660

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt      720

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc      780

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  93
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0018-CTP1 PROTEIN SEQUENCE

<400>  93

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser Lys 
            20                  25                  30          


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
        35                  40                  45              


Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser Ser 
    50                  55                  60                  


Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro 
65                  70                  75                  80  


Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 
                85                  90                  95      


Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 
            100                 105                 110         


Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 
        115                 120                 125             


Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 
    130                 135                 140                 


Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 
145                 150                 155                 160 


Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
                165                 170                 175     


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
            180                 185                 190         


Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 
        195                 200                 205             


Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 
    210                 215                 220                 


Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 
225                 230                 235                 240 


Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 
                245                 250                 255     


Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  94
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0022-CTP1 DNA SEQUENCE

<400>  94
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtggcg cgccgggagg cggaggaagc gactccagca gcagcaaggc ccctccccct      120

agcctgccta gccctagcag gctgcctgga cctagcgata cccccattct gcctcagggc      180

ggcggaggca gcgcctcgag cgagctgcct gtggacgcaa gatttcctcc tagagtgcca      240

aaatcttttc cattcaacac ctcagtcgtg tacaaaaaga ctctgtttgt agaattcacg      300

gatcaccttt tcaacatcgc taagccaagg ccaccctgga tgggtctgct aggtcctacc      360

atccaggctg aggtttatga tacagtggtc attacactta agaacatggc ttcccatcct      420

gtcagtcttc atgctgttgg tgtatcctac tggaaagctt ctgagggagc tgaatatgat      480

gatcagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca      540

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc      600

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc      660

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt      720

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc      780

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  95
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0022-CTP1 PROTEIN SEQUENCE

<400>  95

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser 
            20                  25                  30          


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
        35                  40                  45              


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser 
    50                  55                  60                  


Ala Ser Ser Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro 
65                  70                  75                  80  


Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 
                85                  90                  95      


Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 
            100                 105                 110         


Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 
        115                 120                 125             


Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 
    130                 135                 140                 


Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 
145                 150                 155                 160 


Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
                165                 170                 175     


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
            180                 185                 190         


Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 
        195                 200                 205             


Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 
    210                 215                 220                 


Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 
225                 230                 235                 240 


Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 
                245                 250                 255     


Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  96
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-CTP1 DNA SEQUENCE

<400>  96
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtggg cgcgccggga ggcggaggaa gcgactccag cagcagcaag      120

gcccctcccc ctagcctgcc tagccctagc aggctgcctg gacctagcga tacccccatt      180

ctgcctcagg gcggcggagg cagcgcctcg agcgacgcaa gatttcctcc tagagtgcca      240

aaatcttttc cattcaacac ctcagtcgtg tacaaaaaga ctctgtttgt agaattcacg      300

gatcaccttt tcaacatcgc taagccaagg ccaccctgga tgggtctgct aggtcctacc      360

atccaggctg aggtttatga tacagtggtc attacactta agaacatggc ttcccatcct      420

gtcagtcttc atgctgttgg tgtatcctac tggaaagctt ctgagggagc tgaatatgat      480

gatcagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca      540

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc      600

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc      660

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt      720

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc      780

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  97
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-CTP1 PROTEIN SEQUENCE

<400>  97

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro Gly Gly Gly 
            20                  25                  30          


Gly Ser Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser 
        35                  40                  45              


Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly 
    50                  55                  60                  


Gly Gly Gly Ser Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro 
65                  70                  75                  80  


Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 
                85                  90                  95      


Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 
            100                 105                 110         


Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 
        115                 120                 125             


Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 
    130                 135                 140                 


Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 
145                 150                 155                 160 


Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
                165                 170                 175     


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
            180                 185                 190         


Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 
        195                 200                 205             


Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 
    210                 215                 220                 


Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 
225                 230                 235                 240 


Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 
                245                 250                 255     


Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  98
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0040-CTP1 DNA SEQUENCE

<400>  98
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

ggcgcgccgg gaggcggagg aagcgactcc agcagcagca aggcccctcc ccctagcctg      180

cctagcccta gcaggctgcc tggacctagc gataccccca ttctgcctca gggcggcgga      240

ggcagcgcct cgagcaacac ctcagtcgtg tacaaaaaga ctctgtttgt agaattcacg      300

gatcaccttt tcaacatcgc taagccaagg ccaccctgga tgggtctgct aggtcctacc      360

atccaggctg aggtttatga tacagtggtc attacactta agaacatggc ttcccatcct      420

gtcagtcttc atgctgttgg tgtatcctac tggaaagctt ctgagggagc tgaatatgat      480

gatcagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca      540

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc      600

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc      660

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt      720

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc      780

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  99
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0040-CTP1 PROTEIN SEQUENCE

<400>  99

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Gly Ala Pro Gly Gly Gly Gly Ser 
        35                  40                  45              


Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
    50                  55                  60                  


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Ala Ser Ser Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 
                85                  90                  95      


Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 
            100                 105                 110         


Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 
        115                 120                 125             


Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 
    130                 135                 140                 


Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 
145                 150                 155                 160 


Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
                165                 170                 175     


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
            180                 185                 190         


Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 
        195                 200                 205             


Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 
    210                 215                 220                 


Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 
225                 230                 235                 240 


Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 
                245                 250                 255     


Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  100
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-CTP1 DNA SEQUENCE

<400>  100
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatgg cgcgccggga      360

ggcggaggaa gcgactccag cagcagcaag gcccctcccc ctagcctgcc tagccctagc      420

aggctgcctg gacctagcga tacccccatt ctgcctcagg gcggcggagg cagcgcctcg      480

agccagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca      540

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc      600

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc      660

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt      720

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc      780

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  101
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-CTP1 PROTEIN SEQUENCE

<400>  101

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser 
        115                 120                 125             


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
    130                 135                 140                 


Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser 
145                 150                 155                 160 


Ser Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
                165                 170                 175     


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
            180                 185                 190         


Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp 
        195                 200                 205             


Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys 
    210                 215                 220                 


Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe 
225                 230                 235                 240 


Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu 
                245                 250                 255     


Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  102
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-CTP1 DNA SEQUENCE

<400>  102
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttggg cgcgccggga      660

ggcggaggaa gcgactccag cagcagcaag gcccctcccc ctagcctgcc tagccctagc      720

aggctgcctg gacctagcga tacccccatt ctgcctcagg gcggcggagg cagcgcctcg      780

agcatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat      840

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg      900

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca      960

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1020

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1080

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1140

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1200

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1260

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1320

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  103
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-CTP1 PROTEIN SEQUENCE

<400>  103

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Gly Ala Pro Gly Gly Gly Gly Ser 
    210                 215                 220                 


Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
225                 230                 235                 240 


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly 
                245                 250                 255     


Gly Ser Ala Ser Ser Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala 
            260                 265                 270         


Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro 
        275                 280                 285             


Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly 
    290                 295                 300                 


Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr 
305                 310                 315                 320 


Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile 
                325                 330                 335     


Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu 
            340                 345                 350         


Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr 
        355                 360                 365             


Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn 
    370                 375                 380                 


Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met 
385                 390                 395                 400 


Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile 
                405                 410                 415     


Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala 
            420                 425                 430         


Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  104
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0399-CTP1 DNA SEQUENCE

<400>  104
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcggc     1200

gcgccgggag gcggaggaag cgactccagc agcagcaagg cccctccccc tagcctgcct     1260

agccctagca ggctgcctgg acctagcgat acccccattc tgcctcaggg cggcggaggc     1320

agcgcctcga gcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  105
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0399-CTP1 PROTEIN SEQUENCE

<400>  105

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Gly 
385                 390                 395                 400 


Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser Lys Ala Pro Pro 
                405                 410                 415     


Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro 
            420                 425                 430         


Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser Leu Ala Pro Asp 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  106
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-CTP1 DNA SEQUENCE

<400>  106
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg gcgcgccggg aggcggagga agcgactcca gcagcagcaa ggcccctccc     1260

cctagcctgc ctagccctag caggctgcct ggacctagcg atacccccat tctgcctcag     1320

ggcggcggag gcagcgcctc gagcgacaga agttataaaa gtcaatattt gaacaatggc     1380

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     1440

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     1500

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     1560

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     1620

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     1680

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  107
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-CTP1 PROTEIN SEQUENCE

<400>  107

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser 
                405                 410                 415     


Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser 
        435                 440                 445             


Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
    450                 455                 460                 


Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro 
                485                 490                 495     


Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn 
            500                 505                 510         


Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val 
        515                 520                 525             


Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys 
    530                 535                 540                 


Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val 
545                 550                 555                 560 


Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  108
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-CTP1 DNA SEQUENCE

<400>  108
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaaggcgcg     1560

ccgggaggcg gaggaagcga ctccagcagc agcaaggccc ctccccctag cctgcctagc     1620

cctagcaggc tgcctggacc tagcgatacc cccattctgc ctcagggcgg cggaggcagc     1680

gcctcgagcg atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     1740

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     1800

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     1860

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     1920

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  109
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-CTP1 PROTEIN SEQUENCE

<400>  109

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser 
        515                 520                 525             


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
    530                 535                 540                 


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Ala Ser Ser Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg 
                565                 570                 575     


Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu 
            580                 585                 590         


Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly 
        595                 600                 605             


Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe 
    610                 615                 620                 


Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  110
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-CTP1 DNA SEQUENCE

<400>  110
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctggc     1800

gcgccgggag gcggaggaag cgactccagc agcagcaagg cccctccccc tagcctgcct     1860

agccctagca ggctgcctgg acctagcgat acccccattc tgcctcaggg cggcggaggc     1920

agcgcctcga gcggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     1980

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2040

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2100

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2160

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2220

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2280

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     2340

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     2400

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  111
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-CTP1 PROTEIN SEQUENCE

<400>  111

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Ala Pro Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
    610                 615                 620                 


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Ala Ser Ser Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser 
                645                 650                 655     


Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu 
            660                 665                 670         


Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly 
        675                 680                 685             


Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys 
    690                 695                 700                 


His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly 
705                 710                 715                 720 


Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly 
                725                 730                 735     


Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys 
            740                 745                 750         


Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr 
        755                 760                 765             


Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro 
    770                 775                 780                 


Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 
785                 790                 795                 800 


Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  112
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-CTP1 DNA SEQUENCE

<400>  112
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagggcg cgccgggagg cggaggaagc gactccagca gcagcaaggc ccctccccct     2340

agcctgccta gccctagcag gctgcctgga cctagcgata cccccattct gcctcagggc     2400

ggcggaggca gcgcctcgag ctcagatcaa gaggaaatcg attatgatga taccatatca     2460

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     2520

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     2580

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  113
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-CTP1 PROTEIN SEQUENCE

<400>  113

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro Gly Gly Gly 
        755                 760                 765             


Gly Ser Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser 
    770                 775                 780                 


Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly 
785                 790                 795                 800 


Gly Gly Gly Ser Ala Ser Ser Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
                805                 810                 815     


Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 
            820                 825                 830         


Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 
        835                 840                 845             


Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  114
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1711-CTP1 DNA SEQUENCE

<400>  114
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gggcgcgccg     2460

ggaggcggag gaagcgactc cagcagcagc aaggcccctc cccctagcct gcctagccct     2520

agcaggctgc ctggacctag cgataccccc attctgcctc agggcggcgg aggcagcgcc     2580

tcgagcagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     2640

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     2700

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     2760

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     2820

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     2880

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     2940

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3000

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  115
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1711-CTP1 PROTEIN SEQUENCE

<400>  115

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Gly Ala Pro Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser Lys Ala 
            820                 825                 830         


Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp 
        835                 840                 845             


Thr Pro Ile Leu Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser Ser Ser 
    850                 855                 860                 


Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln 
865                 870                 875                 880 


Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 
                885                 890                 895     


Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 
            900                 905                 910         


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 
        915                 920                 925             


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 
    930                 935                 940                 


Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro 
945                 950                 955                 960 


Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
                965                 970                 975     


Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
            980                 985                 990         


Asp Leu Glu Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
        995                 1000                 1005             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  116
<211>  4551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-CTP1 DNA SEQUENCE

<400>  116
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagggc gcgccgggag gcggaggaag cgactccagc     2520

agcagcaagg cccctccccc tagcctgcct agccctagca ggctgcctgg acctagcgat     2580

acccccattc tgcctcaggg cggcggaggc agcgcctcga gcagggctca gagtggcagt     2640

gtccctcagt tcaagaaagt tgttttccag gaatttactg atggctcctt tactcagccc     2700

ttataccgtg gagaactaaa tgaacatttg ggactcctgg ggccatatat aagagcagaa     2760

gttgaagata atatcatggt aactttcaga aatcaggcct ctcgtcccta ttccttctat     2820

tctagcctta tttcttatga ggaagatcag aggcaaggag cagaacctag aaaaaacttt     2880

gtcaagccta atgaaaccaa aacttacttt tggaaagtgc aacatcatat ggcacccact     2940

aaagatgagt ttgactgcaa agcctgggct tatttctctg atgttgacct ggaaaaagat     3000

gtgcactcag gcctgattgg accccttctg gtctgccaca ctaacacact gaaccctgct     3060

catgggagac aagtgacagt acaggaattt gctctgtttt tcaccatctt tgatgagacc     3120

aaaagctggt acttcactga aaatatggaa agaaactgca gggctccctg caatatccag     3180

atggaagatc ccacttttaa agagaattat cgcttccatg caatcaatgg ctacataatg     3240

gatacactac ctggcttagt aatggctcag gatcaaagga ttcgatggta tctgctcagc     3300

atgggcagca atgaaaacat ccattctatt catttcagtg gacatgtgtt cactgtacga     3360

aaaaaagagg agtataaaat ggcactgtac aatctctatc caggtgtttt tgagacagtg     3420

gaaatgttac catccaaagc tggaatttgg cgggtggaat gccttattgg cgagcatcta     3480

catgctggga tgagcacact ttttctggtg tacagcaata agtgtcagac tcccctggga     3540

atggcttctg gacacattag agattttcag attacagctt caggacaata tggacagtgg     3600

gccccaaagc tggccagact tcattattcc ggatcaatca atgcctggag caccaaggag     3660

cccttttctt ggatcaaggt ggatctgttg gcaccaatga ttattcacgg catcaagacc     3720

cagggtgccc gtcagaagtt ctccagcctc tacatctctc agtttatcat catgtatagt     3780

cttgatggga agaagtggca gacttatcga ggaaattcca ctggaacctt aatggtcttc     3840

tttggcaatg tggattcatc tgggataaaa cacaatattt ttaaccctcc aattattgct     3900

cgatacatcc gtttgcaccc aactcattat agcattcgca gcactcttcg catggagttg     3960

atgggctgtg atttaaatag ttgcagcatg ccattgggaa tggagagtaa agcaatatca     4020

gatgcacaga ttactgcttc atcctacttt accaatatgt ttgccacctg gtctccttca     4080

aaagctcgac ttcacctcca agggaggagt aatgcctgga gacctcaggt gaataatcca     4140

aaagagtggc tgcaagtgga cttccagaag acaatgaaag tcacaggagt aactactcag     4200

ggagtaaaat ctctgcttac cagcatgtat gtgaaggagt tcctcatctc cagcagtcaa     4260

gatggccatc agtggactct cttttttcag aatggcaaag taaaggtttt tcagggaaat     4320

caagactcct tcacacctgt ggtgaactct ctagacccac cgttactgac tcgctacctt     4380

cgaattcacc cccagagttg ggtgcaccag attgccctga ggatggaggt tctgggctgc     4440

gaggcacagg acctctacgg cgccggatca cctggggccg aaacggccga acaaaaactc     4500

atctcagaag aggatctgtc acctgcaacc ggtcatcatc accatcacca t              4551


<210>  117
<211>  1517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-CTP1 PROTEIN SEQUENCE

<400>  117

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Gly Ala Pro 
            820                 825                 830         


Gly Gly Gly Gly Ser Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
        835                 840                 845             


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
    850                 855                 860                 


Pro Gln Gly Gly Gly Gly Ser Ala Ser Ser Arg Ala Gln Ser Gly Ser 
865                 870                 875                 880 


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
                885                 890                 895     


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
            900                 905                 910         


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
        915                 920                 925             


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
    930                 935                 940                 


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
945                 950                 955                 960 


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
                965                 970                 975     


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
            980                 985                 990         


Ser Asp Val Asp Leu Glu Lys Asp  Val His Ser Gly Leu  Ile Gly Pro 
        995                 1000                 1005             


Leu Leu  Val Cys His Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg 
    1010                 1015                 1020             


Gln Val  Thr Val Gln Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp 
    1025                 1030                 1035             


Glu Thr  Lys Ser Trp Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys 
    1040                 1045                 1050             


Arg Ala  Pro Cys Asn Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu 
    1055                 1060                 1065             


Asn Tyr  Arg Phe His Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu 
    1070                 1075                 1080             


Pro Gly  Leu Val Met Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu 
    1085                 1090                 1095             


Leu Ser  Met Gly Ser Asn Glu  Asn Ile His Ser Ile  His Phe Ser 
    1100                 1105                 1110             


Gly His  Val Phe Thr Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala 
    1115                 1120                 1125             


Leu Tyr  Asn Leu Tyr Pro Gly  Val Phe Glu Thr Val  Glu Met Leu 
    1130                 1135                 1140             


Pro Ser  Lys Ala Gly Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu 
    1145                 1150                 1155             


His Leu  His Ala Gly Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn 
    1160                 1165                 1170             


Lys Cys  Gln Thr Pro Leu Gly  Met Ala Ser Gly His  Ile Arg Asp 
    1175                 1180                 1185             


Phe Gln  Ile Thr Ala Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys 
    1190                 1195                 1200             


Leu Ala  Arg Leu His Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr 
    1205                 1210                 1215             


Lys Glu  Pro Phe Ser Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met 
    1220                 1225                 1230             


Ile Ile  His Gly Ile Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser 
    1235                 1240                 1245             


Ser Leu  Tyr Ile Ser Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly 
    1250                 1255                 1260             


Lys Lys  Trp Gln Thr Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met 
    1265                 1270                 1275             


Val Phe  Phe Gly Asn Val Asp  Ser Ser Gly Ile Lys  His Asn Ile 
    1280                 1285                 1290             


Phe Asn  Pro Pro Ile Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr 
    1295                 1300                 1305             


His Tyr  Ser Ile Arg Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys 
    1310                 1315                 1320             


Asp Leu  Asn Ser Cys Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala 
    1325                 1330                 1335             


Ile Ser  Asp Ala Gln Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met 
    1340                 1345                 1350             


Phe Ala  Thr Trp Ser Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly 
    1355                 1360                 1365             


Arg Ser  Asn Ala Trp Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp 
    1370                 1375                 1380             


Leu Gln  Val Asp Phe Gln Lys  Thr Met Lys Val Thr  Gly Val Thr 
    1385                 1390                 1395             


Thr Gln  Gly Val Lys Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu 
    1400                 1405                 1410             


Phe Leu  Ile Ser Ser Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe 
    1415                 1420                 1425             


Phe Gln  Asn Gly Lys Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser 
    1430                 1435                 1440             


Phe Thr  Pro Val Val Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg 
    1445                 1450                 1455             


Tyr Leu  Arg Ile His Pro Gln  Ser Trp Val His Gln  Ile Ala Leu 
    1460                 1465                 1470             


Arg Met  Glu Val Leu Gly Cys  Glu Ala Gln Asp Leu  Tyr Gly Ala 
    1475                 1480                 1485             


Gly Ser  Pro Gly Ala Glu Thr  Ala Glu Gln Lys Leu  Ile Ser Glu 
    1490                 1495                 1500             


Glu Asp  Leu Ser Pro Ala Thr  Gly His His His His  His His 
    1505                 1510                 1515         


<210>  118
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-CTP1 DNA SEQUENCE

<400>  118
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cggcgcgccg ggaggcggag gaagcgactc cagcagcagc     2940

aaggcccctc cccctagcct gcctagccct agcaggctgc ctggacctag cgataccccc     3000

attctgcctc agggcggcgg aggcagcgcc tcgagcacac tgaaccctgc tcatgggaga     3060

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3120

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  119
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-CTP1 PROTEIN SEQUENCE

<400>  119

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Gly Ala Pro Gly Gly Gly Gly Ser Asp 
                965                 970                 975     


Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
            980                 985                 990         


Leu Pro Gly Pro Ser Asp Thr Pro  Ile Leu Pro Gln Gly  Gly Gly Gly 
        995                 1000                 1005             


Ser Ala  Ser Ser Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1010                 1015                 1020             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1025                 1030                 1035             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  120
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-CTP1 DNA SEQUENCE

<400>  120
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggg cgcgccggga ggcggaggaa gcgactccag cagcagcaag     3060

gcccctcccc ctagcctgcc tagccctagc aggctgcctg gacctagcga tacccccatt     3120

ctgcctcagg gcggcggagg cagcgcctcg agcgctccct gcaatatcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  121
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-CTP1 PROTEIN SEQUENCE

<400>  121

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Gly Ala 
        995                 1000                 1005             


Pro Gly  Gly Gly Gly Ser Asp  Ser Ser Ser Ser Lys  Ala Pro Pro 
    1010                 1015                 1020             


Pro Ser  Leu Pro Ser Pro Ser  Arg Leu Pro Gly Pro  Ser Asp Thr 
    1025                 1030                 1035             


Pro Ile  Leu Pro Gln Gly Gly  Gly Gly Ser Ala Ser  Ser Ala Pro 
    1040                 1045                 1050             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  122
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1905-CTP1 DNA SEQUENCE

<400>  122
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atcggcgcgc cgggaggcgg aggaagcgac     3060

tccagcagca gcaaggcccc tccccctagc ctgcctagcc ctagcaggct gcctggacct     3120

agcgataccc ccattctgcc tcagggcggc ggaggcagcg cctcgagcca gatggaagat     3180

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  123
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1905-CTP1 PROTEIN SEQUENCE

<400>  123

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gly Ala Pro Gly  Gly Gly Gly Ser Asp  Ser Ser Ser 
    1010                 1015                 1020             


Ser Lys  Ala Pro Pro Pro Ser  Leu Pro Ser Pro Ser  Arg Leu Pro 
    1025                 1030                 1035             


Gly Pro  Ser Asp Thr Pro Ile  Leu Pro Gln Gly Gly  Gly Gly Ser 
    1040                 1045                 1050             


Ala Ser  Ser Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  124
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1910-CTP1 DNA SEQUENCE

<400>  124
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccgg cgcgccggga     3060

ggcggaggaa gcgactccag cagcagcaag gcccctcccc ctagcctgcc tagccctagc     3120

aggctgcctg gacctagcga tacccccatt ctgcctcagg gcggcggagg cagcgcctcg     3180

agcactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3240

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3300

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     3360

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     3420

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     3480

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     3540

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     3600

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     3660

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     3720

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     3780

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  125
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1910-CTP1 PROTEIN SEQUENCE

<400>  125

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Gly Ala Pro Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Asp  Ser Ser Ser Ser Lys  Ala Pro Pro Pro Ser  Leu Pro Ser 
    1025                 1030                 1035             


Pro Ser  Arg Leu Pro Gly Pro  Ser Asp Thr Pro Ile  Leu Pro Gln 
    1040                 1045                 1050             


Gly Gly  Gly Gly Ser Ala Ser  Ser Thr Phe Lys Glu  Asn Tyr Arg 
    1055                 1060                 1065             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1070                 1075                 1080             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1085                 1090                 1095             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1100                 1105                 1110             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1115                 1120                 1125             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1130                 1135                 1140             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1145                 1150                 1155             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1160                 1165                 1170             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1175                 1180                 1185             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1190                 1195                 1200             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1205                 1210                 1215             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1220                 1225                 1230             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1235                 1240                 1245             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  126
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-CTP1 DNA SEQUENCE

<400>  126
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gggcgcgccg     3660

ggaggcggag gaagcgactc cagcagcagc aaggcccctc cccctagcct gcctagccct     3720

agcaggctgc ctggacctag cgataccccc attctgcctc agggcggcgg aggcagcgcc     3780

tcgagctggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     3840

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     3900

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     3960

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  127
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-CTP1 PROTEIN SEQUENCE

<400>  127

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Gly 
    1205                 1210                 1215             


Ala Pro  Gly Gly Gly Gly Ser  Asp Ser Ser Ser Ser  Lys Ala Pro 
    1220                 1225                 1230             


Pro Pro  Ser Leu Pro Ser Pro  Ser Arg Leu Pro Gly  Pro Ser Asp 
    1235                 1240                 1245             


Thr Pro  Ile Leu Pro Gln Gly  Gly Gly Gly Ser Ala  Ser Ser Trp 
    1250                 1255                 1260             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1265                 1270                 1275             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1280                 1285                 1290             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1295                 1300                 1305             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1310                 1315                 1320             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1325                 1330                 1335             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  128
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-CTP1 DNA SEQUENCE

<400>  128
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg caggcgcgcc gggaggcgga     3900

ggaagcgact ccagcagcag caaggcccct ccccctagcc tgcctagccc tagcaggctg     3960

cctggaccta gcgatacccc cattctgcct cagggcggcg gaggcagcgc ctcgagccag     4020

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4080

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4140

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4200

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4260

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4320

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     4380

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     4440

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     4500

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        4542


<210>  129
<211>  1514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-CTP1 PROTEIN SEQUENCE

<400>  129

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gly  Ala Pro Gly Gly Gly  Gly Ser Asp Ser Ser  Ser Ser Lys 
    1295                 1300                 1305             


Ala Pro  Pro Pro Ser Leu Pro  Ser Pro Ser Arg Leu  Pro Gly Pro 
    1310                 1315                 1320             


Ser Asp  Thr Pro Ile Leu Pro  Gln Gly Gly Gly Gly  Ser Ala Ser 
    1325                 1330                 1335             


Ser Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1340                 1345                 1350             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1355                 1360                 1365             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1370                 1375                 1380             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1385                 1390                 1395             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1400                 1405                 1410             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1415                 1420                 1425             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1430                 1435                 1440             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1445                 1450                 1455             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1460                 1465                 1470             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro 
    1475                 1480                 1485             


Gly Ala  Glu Thr Ala Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu 
    1490                 1495                 1500             


Ser Pro  Ala Thr Gly His His  His His His His 
    1505                 1510                 


<210>  130
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-ABP1 DNA SEQUENCE

<400>  130
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtggg cgcgccgggc ggaggaggct ccggaggagg cggaagcagg      120

ctgatcgagg acatctgcct gcccaggtgg ggctgtctgt gggaagatga cggaggcggc      180

ggaagcggag gcggaggaag cgcctcgagc gacgcaagat ttcctcctag agtgccaaaa      240

tcttttccat tcaacacctc agtcgtgtac aaaaagactc tgtttgtaga attcacggat      300

caccttttca acatcgctaa gccaaggcca ccctggatgg gtctgctagg tcctaccatc      360

caggctgagg tttatgatac agtggtcatt acacttaaga acatggcttc ccatcctgtc      420

agtcttcatg ctgttggtgt atcctactgg aaagcttctg agggagctga atatgatgat      480

cagaccagtc aaagggagaa agaagatgat aaagtcttcc ctggtggaag ccatacatat      540

gtctggcagg tcctgaaaga gaatggtcca atggcctctg acccactgtg ccttacctac      600

tcatatcttt ctcatgtgga cctggtaaaa gacttgaatt caggcctcat tggagcccta      660

ctagtatgta gagaagggag tctggccaag gaaaagacac agaccttgca caaatttata      720

ctactttttg ctgtatttga tgaagggaaa agttggcact cagaaacaaa gaactccttg      780

atgcaggata gggatgctgc atctgctcgg gcctggccta aaatgcacac agtcaatggt      840

tatgtaaaca ggtctctgcc aggtctgatt ggatgccaca ggaaatcagt ctattggcat      900

gtgattggaa tgggcaccac tcctgaagtg cactcaatat tcctcgaagg tcacacattt      960

cttgtgagga accatcgcca ggctagcttg gaaatctcgc caataacttt ccttactgct     1020

caaacactct tgatggacct tggacagttt ctactgtttt gtcatatctc ttcccaccaa     1080

catgatggca tggaagctta tgtcaaagta gacagctgtc cagaggaacc ccaactacga     1140

atgaaaaata atgaagaagc ggaagactat gatgatgatc ttactgattc tgaaatggat     1200

gtggtcaggt ttgatgatga caactctcct tcctttatcc aaattcgctc agttgccaag     1260

aagcatccta aaacttgggt acattacatt gctgctgaag aggaggactg ggactatgct     1320

cccttagtcc tcgcccccga tgacagaagt tataaaagtc aatatttgaa caatggccct     1380

cagcggattg gtaggaagta caaaaaagtc cgatttatgg catacacaga tgaaaccttt     1440

aagactcgtg aagctattca gcatgaatca ggaatcttgg gacctttact ttatggggaa     1500

gttggagaca cactgttgat tatatttaag aatcaagcaa gcagaccata taacatctac     1560

cctcacggaa tcactgatgt ccgtcctttg tattcaagga gattaccaaa aggtgtaaaa     1620

catttgaagg attttccaat tctgccagga gaaatattca aatataaatg gacagtgact     1680

gtagaagatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1740

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1800

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1860

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1920

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  131
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-ABP1 PROTEIN SEQUENCE

<400>  131

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro 
        35                  40                  45              


Arg Trp Gly Cys Leu Trp Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys 
65                  70                  75                  80  


Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val 
                85                  90                  95      


Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp 
            100                 105                 110         


Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val 
        115                 120                 125             


Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala 
    130                 135                 140                 


Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp 
145                 150                 155                 160 


Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly 
                165                 170                 175     


Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala 
            180                 185                 190         


Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu 
        195                 200                 205             


Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg 
    210                 215                 220                 


Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile 
225                 230                 235                 240 


Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr 
                245                 250                 255     


Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp 
            260                 265                 270         


Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly 
        275                 280                 285             


Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met 
    290                 295                 300                 


Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe 
305                 310                 315                 320 


Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr 
                325                 330                 335     


Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu 
            340                 345                 350         


Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val 
        355                 360                 365             


Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn 
    370                 375                 380                 


Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp 
385                 390                 395                 400 


Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg 
                405                 410                 415     


Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala 
            420                 425                 430         


Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp 
        435                 440                 445             


Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
    450                 455                 460                 


Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe 
465                 470                 475                 480 


Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu 
                485                 490                 495     


Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln 
            500                 505                 510         


Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg 
        515                 520                 525             


Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp 
    530                 535                 540                 


Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr 
545                 550                 555                 560 


Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr 
                565                 570                 575     


Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile 
            580                 585                 590         


Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn 
        595                 600                 605             


Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp 
    610                 615                 620                 


Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro 
625                 630                 635                 640 


Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  132
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-ABP1 DNA SEQUENCE

<400>  132
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatgg cgcgccgggc      360

ggaggaggct ccggaggagg cggaagcagg ctgatcgagg acatctgcct gcccaggtgg      420

ggctgtctgt gggaagatga cggaggcggc ggaagcggag gcggaggaag cgcctcgagc      480

cagaccagtc aaagggagaa agaagatgat aaagtcttcc ctggtggaag ccatacatat      540

gtctggcagg tcctgaaaga gaatggtcca atggcctctg acccactgtg ccttacctac      600

tcatatcttt ctcatgtgga cctggtaaaa gacttgaatt caggcctcat tggagcccta      660

ctagtatgta gagaagggag tctggccaag gaaaagacac agaccttgca caaatttata      720

ctactttttg ctgtatttga tgaagggaaa agttggcact cagaaacaaa gaactccttg      780

atgcaggata gggatgctgc atctgctcgg gcctggccta aaatgcacac agtcaatggt      840

tatgtaaaca ggtctctgcc aggtctgatt ggatgccaca ggaaatcagt ctattggcat      900

gtgattggaa tgggcaccac tcctgaagtg cactcaatat tcctcgaagg tcacacattt      960

cttgtgagga accatcgcca ggctagcttg gaaatctcgc caataacttt ccttactgct     1020

caaacactct tgatggacct tggacagttt ctactgtttt gtcatatctc ttcccaccaa     1080

catgatggca tggaagctta tgtcaaagta gacagctgtc cagaggaacc ccaactacga     1140

atgaaaaata atgaagaagc ggaagactat gatgatgatc ttactgattc tgaaatggat     1200

gtggtcaggt ttgatgatga caactctcct tcctttatcc aaattcgctc agttgccaag     1260

aagcatccta aaacttgggt acattacatt gctgctgaag aggaggactg ggactatgct     1320

cccttagtcc tcgcccccga tgacagaagt tataaaagtc aatatttgaa caatggccct     1380

cagcggattg gtaggaagta caaaaaagtc cgatttatgg catacacaga tgaaaccttt     1440

aagactcgtg aagctattca gcatgaatca ggaatcttgg gacctttact ttatggggaa     1500

gttggagaca cactgttgat tatatttaag aatcaagcaa gcagaccata taacatctac     1560

cctcacggaa tcactgatgt ccgtcctttg tattcaagga gattaccaaa aggtgtaaaa     1620

catttgaagg attttccaat tctgccagga gaaatattca aatataaatg gacagtgact     1680

gtagaagatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1740

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1800

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1860

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1920

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  133
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-ABP1 PROTEIN SEQUENCE

<400>  133

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
    130                 135                 140                 


Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser 
145                 150                 155                 160 


Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly 
                165                 170                 175     


Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala 
            180                 185                 190         


Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu 
        195                 200                 205             


Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg 
    210                 215                 220                 


Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile 
225                 230                 235                 240 


Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr 
                245                 250                 255     


Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp 
            260                 265                 270         


Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly 
        275                 280                 285             


Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met 
    290                 295                 300                 


Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe 
305                 310                 315                 320 


Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr 
                325                 330                 335     


Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu 
            340                 345                 350         


Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val 
        355                 360                 365             


Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn 
    370                 375                 380                 


Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp 
385                 390                 395                 400 


Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg 
                405                 410                 415     


Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala 
            420                 425                 430         


Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp 
        435                 440                 445             


Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
    450                 455                 460                 


Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe 
465                 470                 475                 480 


Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu 
                485                 490                 495     


Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln 
            500                 505                 510         


Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg 
        515                 520                 525             


Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp 
    530                 535                 540                 


Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr 
545                 550                 555                 560 


Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr 
                565                 570                 575     


Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile 
            580                 585                 590         


Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn 
        595                 600                 605             


Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp 
    610                 615                 620                 


Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro 
625                 630                 635                 640 


Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  134
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-ABP1 DNA SEQUENCE

<400>  134
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttggg cgcgccgggc      660

ggaggaggct ccggaggagg cggaagcagg ctgatcgagg acatctgcct gcccaggtgg      720

ggctgtctgt gggaagatga cggaggcggc ggaagcggag gcggaggaag cgcctcgagc      780

atgcaggata gggatgctgc atctgctcgg gcctggccta aaatgcacac agtcaatggt      840

tatgtaaaca ggtctctgcc aggtctgatt ggatgccaca ggaaatcagt ctattggcat      900

gtgattggaa tgggcaccac tcctgaagtg cactcaatat tcctcgaagg tcacacattt      960

cttgtgagga accatcgcca ggctagcttg gaaatctcgc caataacttt ccttactgct     1020

caaacactct tgatggacct tggacagttt ctactgtttt gtcatatctc ttcccaccaa     1080

catgatggca tggaagctta tgtcaaagta gacagctgtc cagaggaacc ccaactacga     1140

atgaaaaata atgaagaagc ggaagactat gatgatgatc ttactgattc tgaaatggat     1200

gtggtcaggt ttgatgatga caactctcct tcctttatcc aaattcgctc agttgccaag     1260

aagcatccta aaacttgggt acattacatt gctgctgaag aggaggactg ggactatgct     1320

cccttagtcc tcgcccccga tgacagaagt tataaaagtc aatatttgaa caatggccct     1380

cagcggattg gtaggaagta caaaaaagtc cgatttatgg catacacaga tgaaaccttt     1440

aagactcgtg aagctattca gcatgaatca ggaatcttgg gacctttact ttatggggaa     1500

gttggagaca cactgttgat tatatttaag aatcaagcaa gcagaccata taacatctac     1560

cctcacggaa tcactgatgt ccgtcctttg tattcaagga gattaccaaa aggtgtaaaa     1620

catttgaagg attttccaat tctgccagga gaaatattca aatataaatg gacagtgact     1680

gtagaagatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1740

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1800

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1860

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1920

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  135
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-ABP1 PROTEIN SEQUENCE

<400>  135

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Gly Ala Pro Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp 
225                 230                 235                 240 


Gly Cys Leu Trp Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Ala Ser Ser Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp 
            260                 265                 270         


Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly 
        275                 280                 285             


Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met 
    290                 295                 300                 


Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe 
305                 310                 315                 320 


Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr 
                325                 330                 335     


Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu 
            340                 345                 350         


Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val 
        355                 360                 365             


Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn 
    370                 375                 380                 


Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp 
385                 390                 395                 400 


Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg 
                405                 410                 415     


Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala 
            420                 425                 430         


Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp 
        435                 440                 445             


Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
    450                 455                 460                 


Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe 
465                 470                 475                 480 


Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu 
                485                 490                 495     


Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln 
            500                 505                 510         


Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg 
        515                 520                 525             


Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp 
    530                 535                 540                 


Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr 
545                 550                 555                 560 


Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr 
                565                 570                 575     


Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile 
            580                 585                 590         


Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn 
        595                 600                 605             


Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp 
    610                 615                 620                 


Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro 
625                 630                 635                 640 


Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  136
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-ABP1 DNA SEQUENCE

<400>  136
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg gcgcgccggg cggaggaggc tccggaggag gcggaagcag gctgatcgag     1260

gacatctgcc tgcccaggtg gggctgtctg tgggaagatg acggaggcgg cggaagcgga     1320

ggcggaggaa gcgcctcgag cgacagaagt tataaaagtc aatatttgaa caatggccct     1380

cagcggattg gtaggaagta caaaaaagtc cgatttatgg catacacaga tgaaaccttt     1440

aagactcgtg aagctattca gcatgaatca ggaatcttgg gacctttact ttatggggaa     1500

gttggagaca cactgttgat tatatttaag aatcaagcaa gcagaccata taacatctac     1560

cctcacggaa tcactgatgt ccgtcctttg tattcaagga gattaccaaa aggtgtaaaa     1620

catttgaagg attttccaat tctgccagga gaaatattca aatataaatg gacagtgact     1680

gtagaagatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1740

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1800

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1860

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1920

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  137
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-ABP1 PROTEIN SEQUENCE

<400>  137

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
            420                 425                 430         


Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Asp 
        435                 440                 445             


Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
    450                 455                 460                 


Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe 
465                 470                 475                 480 


Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu 
                485                 490                 495     


Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln 
            500                 505                 510         


Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg 
        515                 520                 525             


Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp 
    530                 535                 540                 


Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr 
545                 550                 555                 560 


Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr 
                565                 570                 575     


Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile 
            580                 585                 590         


Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn 
        595                 600                 605             


Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp 
    610                 615                 620                 


Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro 
625                 630                 635                 640 


Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  138
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-ABP1 DNA SEQUENCE

<400>  138
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaaggcgcg     1560

ccgggcggag gaggctccgg aggaggcgga agcaggctga tcgaggacat ctgcctgccc     1620

aggtggggct gtctgtggga agatgacgga ggcggcggaa gcggaggcgg aggaagcgcc     1680

tcgagcgatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1740

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1800

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1860

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1920

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  139
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-ABP1 PROTEIN SEQUENCE

<400>  139

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys 
    530                 535                 540                 


Leu Trp Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
545                 550                 555                 560 


Ser Ser Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr 
                565                 570                 575     


Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile 
            580                 585                 590         


Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn 
        595                 600                 605             


Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp 
    610                 615                 620                 


Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro 
625                 630                 635                 640 


Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  140
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-ABP1 DNA SEQUENCE

<400>  140
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctggc     1800

gcgccgggcg gaggaggctc cggaggaggc ggaagcaggc tgatcgagga catctgcctg     1860

cccaggtggg gctgtctgtg ggaagatgac ggaggcggcg gaagcggagg cggaggaagc     1920

gcctcgagcg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1980

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     2040

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     2100

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     2160

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2220

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2280

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2340

attgaaccaa gaagcttctc tcaaaaccca ccagtcttga aacgccatca acgggaaata     2400

actcgtacta ctcttcagtc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  141
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-ABP1 PROTEIN SEQUENCE

<400>  141

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Ala Pro Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly 
    610                 615                 620                 


Cys Leu Trp Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Ala Ser Ser Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn 
                645                 650                 655     


Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser 
            660                 665                 670         


Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala 
        675                 680                 685             


Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His 
    690                 695                 700                 


Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu 
705                 710                 715                 720 


Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys 
                725                 730                 735     


His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val 
            740                 745                 750         


Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu 
        755                 760                 765             


Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg 
    770                 775                 780                 


Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile 
785                 790                 795                 800 


Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  142
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-ABP1 DNA SEQUENCE

<400>  142
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagggcg cgccgggcgg aggaggctcc ggaggaggcg gaagcaggct gatcgaggac     2340

atctgcctgc ccaggtgggg ctgtctgtgg gaagatgacg gaggcggcgg aagcggaggc     2400

ggaggaagcg cctcgagctc agatcaagag gaaatcgatt atgatgatac catatcagtt     2460

gaaatgaaga aggaagattt tgacatttat gatgaggatg aaaatcagag cccccgcagc     2520

tttcaaaaga aaacacgaca ctattttatt gctgcagtgg agaggctctg ggattatggg     2580

atgagtagct ccccacatgt tctaagaaac agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  143
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-ABP1 PROTEIN SEQUENCE

<400>  143

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro 
    770                 775                 780                 


Arg Trp Gly Cys Leu Trp Glu Asp Asp Gly Gly Gly Gly Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Ser Ala Ser Ser Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp 
                805                 810                 815     


Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 
            820                 825                 830         


Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 
        835                 840                 845             


Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser 
    850                 855                 860                 


Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  144
<211>  4548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-ABP1 DNA SEQUENCE

<400>  144
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagggc gcgccgggcg gaggaggctc cggaggaggc     2520

ggaagcaggc tgatcgagga catctgcctg cccaggtggg gctgtctgtg ggaagatgac     2580

ggaggcggcg gaagcggagg cggaggaagc gcctcgagca gggctcagag tggcagtgtc     2640

cctcagttca agaaagttgt tttccaggaa tttactgatg gctcctttac tcagccctta     2700

taccgtggag aactaaatga acatttggga ctcctggggc catatataag agcagaagtt     2760

gaagataata tcatggtaac tttcagaaat caggcctctc gtccctattc cttctattct     2820

agccttattt cttatgagga agatcagagg caaggagcag aacctagaaa aaactttgtc     2880

aagcctaatg aaaccaaaac ttacttttgg aaagtgcaac atcatatggc acccactaaa     2940

gatgagtttg actgcaaagc ctgggcttat ttctctgatg ttgacctgga aaaagatgtg     3000

cactcaggcc tgattggacc ccttctggtc tgccacacta acacactgaa ccctgctcat     3060

gggagacaag tgacagtaca ggaatttgct ctgtttttca ccatctttga tgagaccaaa     3120

agctggtact tcactgaaaa tatggaaaga aactgcaggg ctccctgcaa tatccagatg     3180

gaagatccca cttttaaaga gaattatcgc ttccatgcaa tcaatggcta cataatggat     3240

acactacctg gcttagtaat ggctcaggat caaaggattc gatggtatct gctcagcatg     3300

ggcagcaatg aaaacatcca ttctattcat ttcagtggac atgtgttcac tgtacgaaaa     3360

aaagaggagt ataaaatggc actgtacaat ctctatccag gtgtttttga gacagtggaa     3420

atgttaccat ccaaagctgg aatttggcgg gtggaatgcc ttattggcga gcatctacat     3480

gctgggatga gcacactttt tctggtgtac agcaataagt gtcagactcc cctgggaatg     3540

gcttctggac acattagaga ttttcagatt acagcttcag gacaatatgg acagtgggcc     3600

ccaaagctgg ccagacttca ttattccgga tcaatcaatg cctggagcac caaggagccc     3660

ttttcttgga tcaaggtgga tctgttggca ccaatgatta ttcacggcat caagacccag     3720

ggtgcccgtc agaagttctc cagcctctac atctctcagt ttatcatcat gtatagtctt     3780

gatgggaaga agtggcagac ttatcgagga aattccactg gaaccttaat ggtcttcttt     3840

ggcaatgtgg attcatctgg gataaaacac aatattttta accctccaat tattgctcga     3900

tacatccgtt tgcacccaac tcattatagc attcgcagca ctcttcgcat ggagttgatg     3960

ggctgtgatt taaatagttg cagcatgcca ttgggaatgg agagtaaagc aatatcagat     4020

gcacagatta ctgcttcatc ctactttacc aatatgtttg ccacctggtc tccttcaaaa     4080

gctcgacttc acctccaagg gaggagtaat gcctggagac ctcaggtgaa taatccaaaa     4140

gagtggctgc aagtggactt ccagaagaca atgaaagtca caggagtaac tactcaggga     4200

gtaaaatctc tgcttaccag catgtatgtg aaggagttcc tcatctccag cagtcaagat     4260

ggccatcagt ggactctctt ttttcagaat ggcaaagtaa aggtttttca gggaaatcaa     4320

gactccttca cacctgtggt gaactctcta gacccaccgt tactgactcg ctaccttcga     4380

attcaccccc agagttgggt gcaccagatt gccctgagga tggaggttct gggctgcgag     4440

gcacaggacc tctacggcgc cggatcacct ggggccgaaa cggccgaaca aaaactcatc     4500

tcagaagagg atctgtcacc tgcaaccggt catcatcacc atcaccat                  4548


<210>  145
<211>  1516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-ABP1 PROTEIN SEQUENCE

<400>  145

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Gly Ala Pro 
            820                 825                 830         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile 
        835                 840                 845             


Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Gly Gly Gly Gly 
    850                 855                 860                 


Ser Gly Gly Gly Gly Ser Ala Ser Ser Arg Ala Gln Ser Gly Ser Val 
865                 870                 875                 880 


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
                885                 890                 895     


Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
            900                 905                 910         


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
        915                 920                 925             


Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
    930                 935                 940                 


Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
945                 950                 955                 960 


Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
                965                 970                 975     


Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
            980                 985                 990         


Asp Val Asp Leu Glu Lys Asp Val  His Ser Gly Leu Ile  Gly Pro Leu 
        995                 1000                 1005             


Leu Val  Cys His Thr Asn Thr  Leu Asn Pro Ala His  Gly Arg Gln 
    1010                 1015                 1020             


Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe Thr Ile  Phe Asp Glu 
    1025                 1030                 1035             


Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met Glu Arg  Asn Cys Arg 
    1040                 1045                 1050             


Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro Thr Phe  Lys Glu Asn 
    1055                 1060                 1065             


Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile Met Asp  Thr Leu Pro 
    1070                 1075                 1080             


Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile Arg Trp  Tyr Leu Leu 
    1085                 1090                 1095             


Ser Met  Gly Ser Asn Glu Asn  Ile His Ser Ile His  Phe Ser Gly 
    1100                 1105                 1110             


His Val  Phe Thr Val Arg Lys  Lys Glu Glu Tyr Lys  Met Ala Leu 
    1115                 1120                 1125             


Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr Val Glu  Met Leu Pro 
    1130                 1135                 1140             


Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys Leu Ile  Gly Glu His 
    1145                 1150                 1155             


Leu His  Ala Gly Met Ser Thr  Leu Phe Leu Val Tyr  Ser Asn Lys 
    1160                 1165                 1170             


Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly His Ile  Arg Asp Phe 
    1175                 1180                 1185             


Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln Trp Ala  Pro Lys Leu 
    1190                 1195                 1200             


Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn Ala Trp  Ser Thr Lys 
    1205                 1210                 1215             


Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu Leu Ala  Pro Met Ile 
    1220                 1225                 1230             


Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg Gln Lys  Phe Ser Ser 
    1235                 1240                 1245             


Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr Ser Leu  Asp Gly Lys 
    1250                 1255                 1260             


Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr Gly Thr  Leu Met Val 
    1265                 1270                 1275             


Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile Lys His  Asn Ile Phe 
    1280                 1285                 1290             


Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg Leu His  Pro Thr His 
    1295                 1300                 1305             


Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu Leu Met  Gly Cys Asp 
    1310                 1315                 1320             


Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met Glu Ser  Lys Ala Ile 
    1325                 1330                 1335             


Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr Phe Thr  Asn Met Phe 
    1340                 1345                 1350             


Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu His Leu  Gln Gly Arg 
    1355                 1360                 1365             


Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn Pro Lys  Glu Trp Leu 
    1370                 1375                 1380             


Gln Val  Asp Phe Gln Lys Thr  Met Lys Val Thr Gly  Val Thr Thr 
    1385                 1390                 1395             


Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met Tyr Val  Lys Glu Phe 
    1400                 1405                 1410             


Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln Trp Thr  Leu Phe Phe 
    1415                 1420                 1425             


Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly Asn Gln  Asp Ser Phe 
    1430                 1435                 1440             


Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro Leu Leu  Thr Arg Tyr 
    1445                 1450                 1455             


Leu Arg  Ile His Pro Gln Ser  Trp Val His Gln Ile  Ala Leu Arg 
    1460                 1465                 1470             


Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp Leu Tyr  Gly Ala Gly 
    1475                 1480                 1485             


Ser Pro  Gly Ala Glu Thr Ala  Glu Gln Lys Leu Ile  Ser Glu Glu 
    1490                 1495                 1500             


Asp Leu  Ser Pro Ala Thr Gly  His His His His His  His 
    1505                 1510                 1515     


<210>  146
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-ABP1 DNA SEQUENCE

<400>  146
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cggcgcgccg ggcggaggag gctccggagg aggcggaagc     2940

aggctgatcg aggacatctg cctgcccagg tggggctgtc tgtgggaaga tgacggaggc     3000

ggcggaagcg gaggcggagg aagcgcctcg agcacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  147
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-ABP1 PROTEIN SEQUENCE

<400>  147

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Gly Ala Pro Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly 
            980                 985                 990         


Cys Leu Trp Glu Asp Asp Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
        995                 1000                 1005             


Ala Ser  Ser Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  148
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-ABP1 DNA SEQUENCE

<400>  148
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggg cgcgccgggc ggaggaggct ccggaggagg cggaagcagg     3060

ctgatcgagg acatctgcct gcccaggtgg ggctgtctgt gggaagatga cggaggcggc     3120

ggaagcggag gcggaggaag cgcctcgagc gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  149
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-ABP1 PROTEIN SEQUENCE

<400>  149

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Gly Ala 
        995                 1000                 1005             


Pro Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Arg  Leu Ile Glu 
    1010                 1015                 1020             


Asp Ile  Cys Leu Pro Arg Trp  Gly Cys Leu Trp Glu  Asp Asp Gly 
    1025                 1030                 1035             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala Ser Ser  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  150
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-ABP1 DNA SEQUENCE

<400>  150
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gggcgcgccg     3660

ggcggaggag gctccggagg aggcggaagc aggctgatcg aggacatctg cctgcccagg     3720

tggggctgtc tgtgggaaga tgacggaggc ggcggaagcg gaggcggagg aagcgcctcg     3780

agctggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  151
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-ABP1 PROTEIN SEQUENCE

<400>  151

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Gly 
    1205                 1210                 1215             


Ala Pro  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Arg Leu Ile 
    1220                 1225                 1230             


Glu Asp  Ile Cys Leu Pro Arg  Trp Gly Cys Leu Trp  Glu Asp Asp 
    1235                 1240                 1245             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Ala Ser  Ser Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  152
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-ABP1 DNA SEQUENCE

<400>  152
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg caggcgcgcc gggcggagga     3900

ggctccggag gaggcggaag caggctgatc gaggacatct gcctgcccag gtggggctgt     3960

ctgtgggaag atgacggagg cggcggaagc ggaggcggag gaagcgcctc gagccagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  153
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-ABP1 PROTEIN SEQUENCE

<400>  153

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gly  Ala Pro Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Arg 
    1295                 1300                 1305             


Leu Ile  Glu Asp Ile Cys Leu  Pro Arg Trp Gly Cys  Leu Trp Glu 
    1310                 1315                 1320             


Asp Asp  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Ala Ser Ser 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  154
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-HAP1 DNA SEQUENCE

<400>  154
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtggg cgcgccggga ggaggcggct ccggcggagg aggaagcggc      120

ggaggaggca gcggaggcgg cggctccggc ggcggcggca gcggcggcgg aggcagcgga      180

ggcggcggca gcgcctcgag cgacgcaaga tttcctccta gagtgccaaa atcttttcca      240

ttcaacacct cagtcgtgta caaaaagact ctgtttgtag aattcacgga tcaccttttc      300

aacatcgcta agccaaggcc accctggatg ggtctgctag gtcctaccat ccaggctgag      360

gtttatgata cagtggtcat tacacttaag aacatggctt cccatcctgt cagtcttcat      420

gctgttggtg tatcctactg gaaagcttct gagggagctg aatatgatga tcagaccagt      480

caaagggaga aagaagatga taaagtcttc cctggtggaa gccatacata tgtctggcag      540

gtcctgaaag agaatggtcc aatggcctct gacccactgt gccttaccta ctcatatctt      600

tctcatgtgg acctggtaaa agacttgaat tcaggcctca ttggagccct actagtatgt      660

agagaaggga gtctggccaa ggaaaagaca cagaccttgc acaaatttat actacttttt      720

gctgtatttg atgaagggaa aagttggcac tcagaaacaa agaactcctt gatgcaggat      780

agggatgctg catctgctcg ggcctggcct aaaatgcaca cagtcaatgg ttatgtaaac      840

aggtctctgc caggtctgat tggatgccac aggaaatcag tctattggca tgtgattgga      900

atgggcacca ctcctgaagt gcactcaata ttcctcgaag gtcacacatt tcttgtgagg      960

aaccatcgcc aggctagctt ggaaatctcg ccaataactt tccttactgc tcaaacactc     1020

ttgatggacc ttggacagtt tctactgttt tgtcatatct cttcccacca acatgatggc     1080

atggaagctt atgtcaaagt agacagctgt ccagaggaac cccaactacg aatgaaaaat     1140

aatgaagaag cggaagacta tgatgatgat cttactgatt ctgaaatgga tgtggtcagg     1200

tttgatgatg acaactctcc ttcctttatc caaattcgct cagttgccaa gaagcatcct     1260

aaaacttggg tacattacat tgctgctgaa gaggaggact gggactatgc tcccttagtc     1320

ctcgcccccg atgacagaag ttataaaagt caatatttga acaatggccc tcagcggatt     1380

ggtaggaagt acaaaaaagt ccgatttatg gcatacacag atgaaacctt taagactcgt     1440

gaagctattc agcatgaatc aggaatcttg ggacctttac tttatgggga agttggagac     1500

acactgttga ttatatttaa gaatcaagca agcagaccat ataacatcta ccctcacgga     1560

atcactgatg tccgtccttt gtattcaagg agattaccaa aaggtgtaaa acatttgaag     1620

gattttccaa ttctgccagg agaaatattc aaatataaat ggacagtgac tgtagaagat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  155
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-HAP1 PROTEIN SEQUENCE

<400>  155

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 
65                  70                  75                  80  


Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 
                85                  90                  95      


Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 
            100                 105                 110         


Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 
        115                 120                 125             


Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 
    130                 135                 140                 


Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 
145                 150                 155                 160 


Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 
                165                 170                 175     


Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 
            180                 185                 190         


Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 
        195                 200                 205             


Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 
    210                 215                 220                 


Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 
225                 230                 235                 240 


Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 
                245                 250                 255     


Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 
            260                 265                 270         


His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 
        275                 280                 285             


Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 
    290                 295                 300                 


Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 
305                 310                 315                 320 


Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 
                325                 330                 335     


Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 
            340                 345                 350         


Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 
        355                 360                 365             


Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 
    370                 375                 380                 


Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 
385                 390                 395                 400 


Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 
                405                 410                 415     


Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 
            420                 425                 430         


Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 
        435                 440                 445             


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
    450                 455                 460                 


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
465                 470                 475                 480 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
                485                 490                 495     


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
            500                 505                 510         


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
        515                 520                 525             


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
    530                 535                 540                 


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  156
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-HAP1 DNA SEQUENCE

<400>  156
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatgg cgcgccggga      360

ggaggcggct ccggcggagg aggaagcggc ggaggaggca gcggaggcgg cggctccggc      420

ggcggcggca gcggcggcgg aggcagcgga ggcggcggca gcgcctcgag ccagaccagt      480

caaagggaga aagaagatga taaagtcttc cctggtggaa gccatacata tgtctggcag      540

gtcctgaaag agaatggtcc aatggcctct gacccactgt gccttaccta ctcatatctt      600

tctcatgtgg acctggtaaa agacttgaat tcaggcctca ttggagccct actagtatgt      660

agagaaggga gtctggccaa ggaaaagaca cagaccttgc acaaatttat actacttttt      720

gctgtatttg atgaagggaa aagttggcac tcagaaacaa agaactcctt gatgcaggat      780

agggatgctg catctgctcg ggcctggcct aaaatgcaca cagtcaatgg ttatgtaaac      840

aggtctctgc caggtctgat tggatgccac aggaaatcag tctattggca tgtgattgga      900

atgggcacca ctcctgaagt gcactcaata ttcctcgaag gtcacacatt tcttgtgagg      960

aaccatcgcc aggctagctt ggaaatctcg ccaataactt tccttactgc tcaaacactc     1020

ttgatggacc ttggacagtt tctactgttt tgtcatatct cttcccacca acatgatggc     1080

atggaagctt atgtcaaagt agacagctgt ccagaggaac cccaactacg aatgaaaaat     1140

aatgaagaag cggaagacta tgatgatgat cttactgatt ctgaaatgga tgtggtcagg     1200

tttgatgatg acaactctcc ttcctttatc caaattcgct cagttgccaa gaagcatcct     1260

aaaacttggg tacattacat tgctgctgaa gaggaggact gggactatgc tcccttagtc     1320

ctcgcccccg atgacagaag ttataaaagt caatatttga acaatggccc tcagcggatt     1380

ggtaggaagt acaaaaaagt ccgatttatg gcatacacag atgaaacctt taagactcgt     1440

gaagctattc agcatgaatc aggaatcttg ggacctttac tttatgggga agttggagac     1500

acactgttga ttatatttaa gaatcaagca agcagaccat ataacatcta ccctcacgga     1560

atcactgatg tccgtccttt gtattcaagg agattaccaa aaggtgtaaa acatttgaag     1620

gattttccaa ttctgccagg agaaatattc aaatataaat ggacagtgac tgtagaagat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  157
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0116-HAP1 PROTEIN SEQUENCE

<400>  157

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Gln Thr Ser 
145                 150                 155                 160 


Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 
                165                 170                 175     


Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 
            180                 185                 190         


Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 
        195                 200                 205             


Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 
    210                 215                 220                 


Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 
225                 230                 235                 240 


Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 
                245                 250                 255     


Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 
            260                 265                 270         


His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 
        275                 280                 285             


Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 
    290                 295                 300                 


Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 
305                 310                 315                 320 


Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 
                325                 330                 335     


Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 
            340                 345                 350         


Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 
        355                 360                 365             


Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 
    370                 375                 380                 


Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 
385                 390                 395                 400 


Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 
                405                 410                 415     


Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 
            420                 425                 430         


Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 
        435                 440                 445             


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
    450                 455                 460                 


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
465                 470                 475                 480 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
                485                 490                 495     


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
            500                 505                 510         


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
        515                 520                 525             


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
    530                 535                 540                 


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  158
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-HAP1 DNA SEQUENCE

<400>  158
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttggg cgcgccggga      660

ggaggcggct ccggcggagg aggaagcggc ggaggaggca gcggaggcgg cggctccggc      720

ggcggcggca gcggcggcgg aggcagcgga ggcggcggca gcgcctcgag catgcaggat      780

agggatgctg catctgctcg ggcctggcct aaaatgcaca cagtcaatgg ttatgtaaac      840

aggtctctgc caggtctgat tggatgccac aggaaatcag tctattggca tgtgattgga      900

atgggcacca ctcctgaagt gcactcaata ttcctcgaag gtcacacatt tcttgtgagg      960

aaccatcgcc aggctagctt ggaaatctcg ccaataactt tccttactgc tcaaacactc     1020

ttgatggacc ttggacagtt tctactgttt tgtcatatct cttcccacca acatgatggc     1080

atggaagctt atgtcaaagt agacagctgt ccagaggaac cccaactacg aatgaaaaat     1140

aatgaagaag cggaagacta tgatgatgat cttactgatt ctgaaatgga tgtggtcagg     1200

tttgatgatg acaactctcc ttcctttatc caaattcgct cagttgccaa gaagcatcct     1260

aaaacttggg tacattacat tgctgctgaa gaggaggact gggactatgc tcccttagtc     1320

ctcgcccccg atgacagaag ttataaaagt caatatttga acaatggccc tcagcggatt     1380

ggtaggaagt acaaaaaagt ccgatttatg gcatacacag atgaaacctt taagactcgt     1440

gaagctattc agcatgaatc aggaatcttg ggacctttac tttatgggga agttggagac     1500

acactgttga ttatatttaa gaatcaagca agcagaccat ataacatcta ccctcacgga     1560

atcactgatg tccgtccttt gtattcaagg agattaccaa aaggtgtaaa acatttgaag     1620

gattttccaa ttctgccagg agaaatattc aaatataaat ggacagtgac tgtagaagat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  159
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0216-HAP1 PROTEIN SEQUENCE

<400>  159

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Gly Ala Pro Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
                245                 250                 255     


Ser Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 
            260                 265                 270         


His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 
        275                 280                 285             


Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 
    290                 295                 300                 


Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 
305                 310                 315                 320 


Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 
                325                 330                 335     


Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 
            340                 345                 350         


Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 
        355                 360                 365             


Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 
    370                 375                 380                 


Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 
385                 390                 395                 400 


Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 
                405                 410                 415     


Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 
            420                 425                 430         


Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 
        435                 440                 445             


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
    450                 455                 460                 


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
465                 470                 475                 480 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
                485                 490                 495     


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
            500                 505                 510         


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
        515                 520                 525             


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
    530                 535                 540                 


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  160
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-HAP1 DNA SEQUENCE

<400>  160
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg gcgcgccggg aggaggcggc tccggcggag gaggaagcgg cggaggaggc     1260

agcggaggcg gcggctccgg cggcggcggc agcggcggcg gaggcagcgg aggcggcggc     1320

agcgcctcga gcgacagaag ttataaaagt caatatttga acaatggccc tcagcggatt     1380

ggtaggaagt acaaaaaagt ccgatttatg gcatacacag atgaaacctt taagactcgt     1440

gaagctattc agcatgaatc aggaatcttg ggacctttac tttatgggga agttggagac     1500

acactgttga ttatatttaa gaatcaagca agcagaccat ataacatcta ccctcacgga     1560

atcactgatg tccgtccttt gtattcaagg agattaccaa aaggtgtaaa acatttgaag     1620

gattttccaa ttctgccagg agaaatattc aaatataaat ggacagtgac tgtagaagat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  161
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-HAP1 PROTEIN SEQUENCE

<400>  161

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Asp Arg Ser Tyr 
        435                 440                 445             


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
    450                 455                 460                 


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
465                 470                 475                 480 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
                485                 490                 495     


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
            500                 505                 510         


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
        515                 520                 525             


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
    530                 535                 540                 


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  162
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-HAP1 DNA SEQUENCE

<400>  162
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaaggcgcg     1560

ccgggaggag gcggctccgg cggaggagga agcggcggag gaggcagcgg aggcggcggc     1620

tccggcggcg gcggcagcgg cggcggaggc agcggaggcg gcggcagcgc ctcgagcgat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  163
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0518-HAP1 PROTEIN SEQUENCE

<400>  163

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  164
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-HAP1 DNA SEQUENCE

<400>  164
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctggc     1800

gcgccgggag gaggcggctc cggcggagga ggaagcggcg gaggaggcag cggaggcggc     1860

ggctccggcg gcggcggcag cggcggcgga ggcagcggag gcggcggcag cgcctcgagc     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  165
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0599-HAP1 PROTEIN SEQUENCE

<400>  165

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Ala Pro Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  166
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-HAP1 DNA SEQUENCE

<400>  166
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagggcg cgccgggagg aggcggctcc ggcggaggag gaagcggcgg aggaggcagc     2340

ggaggcggcg gctccggcgg cggcggcagc ggcggcggag gcagcggagg cggcggcagc     2400

gcctcgagct cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  167
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-HAP1 PROTEIN SEQUENCE

<400>  167

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


Ala Ser Ser Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  168
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-HAP1 DNA SEQUENCE

<400>  168
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagggc gcgccgggag gaggcggctc cggcggagga     2520

ggaagcggcg gaggaggcag cggaggcggc ggctccggcg gcggcggcag cggcggcgga     2580

ggcagcggag gcggcggcag cgcctcgagc agggctcaga gtggcagtgt ccctcagttc     2640

aagaaagttg ttttccagga atttactgat ggctccttta ctcagccctt ataccgtgga     2700

gaactaaatg aacatttggg actcctgggg ccatatataa gagcagaagt tgaagataat     2760

atcatggtaa ctttcagaaa tcaggcctct cgtccctatt ccttctattc tagccttatt     2820

tcttatgagg aagatcagag gcaaggagca gaacctagaa aaaactttgt caagcctaat     2880

gaaaccaaaa cttacttttg gaaagtgcaa catcatatgg cacccactaa agatgagttt     2940

gactgcaaag cctgggctta tttctctgat gttgacctgg aaaaagatgt gcactcaggc     3000

ctgattggac cccttctggt ctgccacact aacacactga accctgctca tgggagacaa     3060

gtgacagtac aggaatttgc tctgtttttc accatctttg atgagaccaa aagctggtac     3120

ttcactgaaa atatggaaag aaactgcagg gctccctgca atatccagat ggaagatccc     3180

acttttaaag agaattatcg cttccatgca atcaatggct acataatgga tacactacct     3240

ggcttagtaa tggctcagga tcaaaggatt cgatggtatc tgctcagcat gggcagcaat     3300

gaaaacatcc attctattca tttcagtgga catgtgttca ctgtacgaaa aaaagaggag     3360

tataaaatgg cactgtacaa tctctatcca ggtgtttttg agacagtgga aatgttacca     3420

tccaaagctg gaatttggcg ggtggaatgc cttattggcg agcatctaca tgctgggatg     3480

agcacacttt ttctggtgta cagcaataag tgtcagactc ccctgggaat ggcttctgga     3540

cacattagag attttcagat tacagcttca ggacaatatg gacagtgggc cccaaagctg     3600

gccagacttc attattccgg atcaatcaat gcctggagca ccaaggagcc cttttcttgg     3660

atcaaggtgg atctgttggc accaatgatt attcacggca tcaagaccca gggtgcccgt     3720

cagaagttct ccagcctcta catctctcag tttatcatca tgtatagtct tgatgggaag     3780

aagtggcaga cttatcgagg aaattccact ggaaccttaa tggtcttctt tggcaatgtg     3840

gattcatctg ggataaaaca caatattttt aaccctccaa ttattgctcg atacatccgt     3900

ttgcacccaa ctcattatag cattcgcagc actcttcgca tggagttgat gggctgtgat     3960

ttaaatagtt gcagcatgcc attgggaatg gagagtaaag caatatcaga tgcacagatt     4020

actgcttcat cctactttac caatatgttt gccacctggt ctccttcaaa agctcgactt     4080

cacctccaag ggaggagtaa tgcctggaga cctcaggtga ataatccaaa agagtggctg     4140

caagtggact tccagaagac aatgaaagtc acaggagtaa ctactcaggg agtaaaatct     4200

ctgcttacca gcatgtatgt gaaggagttc ctcatctcca gcagtcaaga tggccatcag     4260

tggactctct tttttcagaa tggcaaagta aaggtttttc agggaaatca agactccttc     4320

acacctgtgg tgaactctct agacccaccg ttactgactc gctaccttcg aattcacccc     4380

cagagttggg tgcaccagat tgccctgagg atggaggttc tgggctgcga ggcacaggac     4440

ctctacggcg ccggatcacc tggggccgaa acggccgaac aaaaactcat ctcagaagag     4500

gatctgtcac ctgcaaccgg tcatcatcac catcaccat                            4539


<210>  169
<211>  1513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-HAP1 PROTEIN SEQUENCE

<400>  169

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Gly Ala Pro 
            820                 825                 830         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        835                 840                 845             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    850                 855                 860                 


Gly Gly Ser Ala Ser Ser Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 
865                 870                 875                 880 


Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 
                885                 890                 895     


Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 
            900                 905                 910         


Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
        915                 920                 925             


Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu 
    930                 935                 940                 


Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr 
                965                 970                 975     


Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp 
            980                 985                 990         


Leu Glu Lys Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
        995                 1000                 1005             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1010                 1015                 1020             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1025                 1030                 1035             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1040                 1045                 1050             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1055                 1060                 1065             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1070                 1075                 1080             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1085                 1090                 1095             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1100                 1105                 1110             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1115                 1120                 1125             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1130                 1135                 1140             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1145                 1150                 1155             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1160                 1165                 1170             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1190                 1195                 1200             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1205                 1210                 1215             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1220                 1225                 1230             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1235                 1240                 1245             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1250                 1255                 1260             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1265                 1270                 1275             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1280                 1285                 1290             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1295                 1300                 1305             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1310                 1315                 1320             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1325                 1330                 1335             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1340                 1345                 1350             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1355                 1360                 1365             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1370                 1375                 1380             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1385                 1390                 1395             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1400                 1405                 1410             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1415                 1420                 1425             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1430                 1435                 1440             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1445                 1450                 1455             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1460                 1465                 1470             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Gly Ala Gly  Ser Pro Gly 
    1475                 1480                 1485             


Ala Glu  Thr Ala Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Ser 
    1490                 1495                 1500             


Pro Ala  Thr Gly His His His  His His His 
    1505                 1510             


<210>  170
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-HAP1 DNA SEQUENCE

<400>  170
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cggcgcgccg ggaggaggcg gctccggcgg aggaggaagc     2940

ggcggaggag gcagcggagg cggcggctcc ggcggcggcg gcagcggcgg cggaggcagc     3000

ggaggcggcg gcagcgcctc gagcacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  171
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1861-HAP1 PROTEIN SEQUENCE

<400>  171

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Gly Ala Pro Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            980                 985                 990         


Gly Gly Ser Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Ala Ser Ser 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  172
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-HAP1 DNA SEQUENCE

<400>  172
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggg cgcgccggga ggaggcggct ccggcggagg aggaagcggc     3060

ggaggaggca gcggaggcgg cggctccggc ggcggcggca gcggcggcgg aggcagcgga     3120

ggcggcggca gcgcctcgag cgctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  173
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-HAP1 PROTEIN SEQUENCE

<400>  173

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Gly Ala 
        995                 1000                 1005             


Pro Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1025                 1030                 1035             


Ser Gly  Gly Gly Gly Ser Ala  Ser Ser Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  174
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-HAP1 DNA SEQUENCE

<400>  174
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gggcgcgccg     3660

ggaggaggcg gctccggcgg aggaggaagc ggcggaggag gcagcggagg cggcggctcc     3720

ggcggcggcg gcagcggcgg cggaggcagc ggaggcggcg gcagcgcctc gagctggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  175
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2111-HAP1 PROTEIN SEQUENCE

<400>  175

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Gly 
    1205                 1210                 1215             


Ala Pro  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly 
    1220                 1225                 1230             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly 
    1235                 1240                 1245             


Gly Ser  Gly Gly Gly Gly Ser  Ala Ser Ser Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  176
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-HAP1 DNA SEQUENCE

<400>  176
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg caggcgcgcc gggaggaggc     3900

ggctccggcg gaggaggaag cggcggagga ggcagcggag gcggcggctc cggcggcggc     3960

ggcagcggcg gcggaggcag cggaggcggc ggcagcgcct cgagccagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  177
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-2188-HAP1 PROTEIN SEQUENCE

<400>  177

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gly  Ala Pro Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1295                 1300                 1305             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1310                 1315                 1320             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala Ser Ser  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  178
<211>  794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhanced GFP

<400>  178
ggcgcgccgg gcggaggagg aagcggaggc ggaggctcca tggtgagcaa gggcgaagag       60

ctgttcaccg gcgtggtgcc catcctcgtg gaactggacg gcgatgtcaa cggccacaag      120

ttcagcgtca gcggagaggg agaaggcgac gccacctacg gcaagctcac cctgaagttc      180

atctgtacca ccggcaagct gcctgtgccc tggcctacac tggtgaccac cctgacctat      240

ggagtgcagt gctttagcag gtaccccgac cacatgaagc agcacgactt tttcaagagc      300

gccatgcctg aaggctacgt gcaggagagg accatcttct tcaaagacga cggcaactac      360

aagaccaggg ccgaggtcaa gttcgagggc gataccctcg tgaacaggat cgagctgaag      420

ggaatcgact tcaaggagga cggcaacatc ctgggccaca agctggagta caattacaac      480

tcccacaacg tgtatatcat ggccgataaa cagaagaatg gaatcaaagt caatttcaag      540

atcaggcaca atatcgagga cggcagcgtc caactggccg accactatca gcagaatacc      600

cccattggag acggacccgt gctgctcccc gacaaccact acctctccac acagtccgct      660

ctgtccaagg accccaacga gaagagggac catatggtcc tgctggaatt cgtgaccgcc      720

gctggcatca ccctcggcat ggatgagctg tacaagggag gaggaggcag cggaggaggc      780

ggaagcgcct cgag                                                        794


<210>  179
<211>  5202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-EGFP1 DNA SEQUENCE

<400>  179
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtggg cgcgccgggc ggaggaggaa gcggaggcgg aggctccatg      120

gtgagcaagg gcgaagagct gttcaccggc gtggtgccca tcctcgtgga actggacggc      180

gatgtcaacg gccacaagtt cagcgtcagc ggagagggag aaggcgacgc cacctacggc      240

aagctcaccc tgaagttcat ctgtaccacc ggcaagctgc ctgtgccctg gcctacactg      300

gtgaccaccc tgacctatgg agtgcagtgc tttagcaggt accccgacca catgaagcag      360

cacgactttt tcaagagcgc catgcctgaa ggctacgtgc aggagaggac catcttcttc      420

aaagacgacg gcaactacaa gaccagggcc gaggtcaagt tcgagggcga taccctcgtg      480

aacaggatcg agctgaaggg aatcgacttc aaggaggacg gcaacatcct gggccacaag      540

ctggagtaca attacaactc ccacaacgtg tatatcatgg ccgataaaca gaagaatgga      600

atcaaagtca atttcaagat caggcacaat atcgaggacg gcagcgtcca actggccgac      660

cactatcagc agaatacccc cattggagac ggacccgtgc tgctccccga caaccactac      720

ctctccacac agtccgctct gtccaaggac cccaacgaga agagggacca tatggtcctg      780

ctggaattcg tgaccgccgc tggcatcacc ctcggcatgg atgagctgta caagggagga      840

ggaggcagcg gaggaggcgg aagcgcctcg agcgacgcaa gatttcctcc tagagtgcca      900

aaatcttttc cattcaacac ctcagtcgtg tacaaaaaga ctctgtttgt agaattcacg      960

gatcaccttt tcaacatcgc taagccaagg ccaccctgga tgggtctgct aggtcctacc     1020

atccaggctg aggtttatga tacagtggtc attacactta agaacatggc ttcccatcct     1080

gtcagtcttc atgctgttgg tgtatcctac tggaaagctt ctgagggagc tgaatatgat     1140

gatcagacca gtcaaaggga gaaagaagat gataaagtct tccctggtgg aagccataca     1200

tatgtctggc aggtcctgaa agagaatggt ccaatggcct ctgacccact gtgccttacc     1260

tactcatatc tttctcatgt ggacctggta aaagacttga attcaggcct cattggagcc     1320

ctactagtat gtagagaagg gagtctggcc aaggaaaaga cacagacctt gcacaaattt     1380

atactacttt ttgctgtatt tgatgaaggg aaaagttggc actcagaaac aaagaactcc     1440

ttgatgcagg atagggatgc tgcatctgct cgggcctggc ctaaaatgca cacagtcaat     1500

ggttatgtaa acaggtctct gccaggtctg attggatgcc acaggaaatc agtctattgg     1560

catgtgattg gaatgggcac cactcctgaa gtgcactcaa tattcctcga aggtcacaca     1620

tttcttgtga ggaaccatcg ccaggctagc ttggaaatct cgccaataac tttccttact     1680

gctcaaacac tcttgatgga ccttggacag tttctactgt tttgtcatat ctcttcccac     1740

caacatgatg gcatggaagc ttatgtcaaa gtagacagct gtccagagga accccaacta     1800

cgaatgaaaa ataatgaaga agcggaagac tatgatgatg atcttactga ttctgaaatg     1860

gatgtggtca ggtttgatga tgacaactct ccttccttta tccaaattcg ctcagttgcc     1920

aagaagcatc ctaaaacttg ggtacattac attgctgctg aagaggagga ctgggactat     1980

gctcccttag tcctcgcccc cgatgacaga agttataaaa gtcaatattt gaacaatggc     2040

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     2100

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     2160

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     2220

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     2280

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     2340

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     2400

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     2460

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     2520

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     2580

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     2640

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2700

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2760

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2820

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2880

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2940

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     3000

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     3060

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     3120

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     3180

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     3240

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     3300

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     3360

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     3420

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     3480

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     3540

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     3600

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3660

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3720

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3780

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3840

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3900

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3960

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     4020

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     4080

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     4140

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     4200

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     4260

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     4320

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     4380

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     4440

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     4500

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     4560

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     4620

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4680

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4740

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4800

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4860

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4920

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4980

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     5040

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     5100

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     5160

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        5202


<210>  180
<211>  1734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-EGFP1 PROTEIN SEQUENCE

<400>  180

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
        35                  40                  45              


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    50                  55                  60                  


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
65                  70                  75                  80  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
                85                  90                  95      


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
            100                 105                 110         


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
        115                 120                 125             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    130                 135                 140                 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
145                 150                 155                 160 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                165                 170                 175     


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
            180                 185                 190         


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
        195                 200                 205             


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    210                 215                 220                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
225                 230                 235                 240 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                245                 250                 255     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            260                 265                 270         


Met Asp Glu Leu Tyr Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 
    290                 295                 300                 


Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 
305                 310                 315                 320 


Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 
                325                 330                 335     


Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 
            340                 345                 350         


Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 
        355                 360                 365             


Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 
    370                 375                 380                 


Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 
385                 390                 395                 400 


Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 
                405                 410                 415     


Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 
            420                 425                 430         


Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 
        435                 440                 445             


Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 
    450                 455                 460                 


Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 
465                 470                 475                 480 


Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 
                485                 490                 495     


His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 
            500                 505                 510         


Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 
        515                 520                 525             


Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 
    530                 535                 540                 


Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 
545                 550                 555                 560 


Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 
                565                 570                 575     


Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 
            580                 585                 590         


Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 
        595                 600                 605             


Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 
    610                 615                 620                 


Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 
625                 630                 635                 640 


Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 
                645                 650                 655     


Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 
            660                 665                 670         


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
        675                 680                 685             


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
    690                 695                 700                 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
705                 710                 715                 720 


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
                725                 730                 735     


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
            740                 745                 750         


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
        755                 760                 765             


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
    770                 775                 780                 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
785                 790                 795                 800 


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
                805                 810                 815     


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
            820                 825                 830         


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
        835                 840                 845             


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
    850                 855                 860                 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
865                 870                 875                 880 


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
                885                 890                 895     


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
            900                 905                 910         


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
        915                 920                 925             


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
    930                 935                 940                 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
945                 950                 955                 960 


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
                965                 970                 975     


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
            980                 985                 990         


Ala Tyr Leu Leu Ser Lys Asn Asn  Ala Ile Glu Pro Arg  Ser Phe Ser 
        995                 1000                 1005             


Gln Asn  Pro Pro Val Leu Lys  Arg His Gln Arg Glu  Ile Thr Arg 
    1010                 1015                 1020             


Thr Thr  Leu Gln Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 
    1025                 1030                 1035             


Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 
    1040                 1045                 1050             


Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 
    1055                 1060                 1065             


Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 
    1070                 1075                 1080             


Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 
    1085                 1090                 1095             


Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 
    1100                 1105                 1110             


Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 
    1130                 1135                 1140             


Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 
    1145                 1150                 1155             


Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 
    1160                 1165                 1170             


Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1175                 1180                 1185             


Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 
    1190                 1195                 1200             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 
    1205                 1210                 1215             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 
    1220                 1225                 1230             


Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 
    1235                 1240                 1245             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1250                 1255                 1260             


Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 
    1265                 1270                 1275             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1280                 1285                 1290             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1295                 1300                 1305             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1310                 1315                 1320             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1325                 1330                 1335             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1340                 1345                 1350             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1355                 1360                 1365             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1370                 1375                 1380             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1385                 1390                 1395             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1400                 1405                 1410             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1415                 1420                 1425             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1430                 1435                 1440             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1445                 1450                 1455             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1460                 1465                 1470             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1475                 1480                 1485             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1490                 1495                 1500             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1505                 1510                 1515             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1520                 1525                 1530             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1535                 1540                 1545             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1550                 1555                 1560             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1565                 1570                 1575             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1580                 1585                 1590             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1595                 1600                 1605             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1610                 1615                 1620             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1625                 1630                 1635             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1640                 1645                 1650             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1655                 1660                 1665             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1670                 1675                 1680             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1685                 1690                 1695             


Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro Gly Ala  Glu Thr Ala 
    1700                 1705                 1710             


Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu Ser Pro  Ala Thr Gly 
    1715                 1720                 1725             


His His  His His His His 
    1730                 


<210>  181
<211>  5202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-EGFP1 DNA SEQUENCE

<400>  181
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg gcgcgccggg cggaggagga agcggaggcg gaggctccat ggtgagcaag     1260

ggcgaagagc tgttcaccgg cgtggtgccc atcctcgtgg aactggacgg cgatgtcaac     1320

ggccacaagt tcagcgtcag cggagaggga gaaggcgacg ccacctacgg caagctcacc     1380

ctgaagttca tctgtaccac cggcaagctg cctgtgccct ggcctacact ggtgaccacc     1440

ctgacctatg gagtgcagtg ctttagcagg taccccgacc acatgaagca gcacgacttt     1500

ttcaagagcg ccatgcctga aggctacgtg caggagagga ccatcttctt caaagacgac     1560

ggcaactaca agaccagggc cgaggtcaag ttcgagggcg ataccctcgt gaacaggatc     1620

gagctgaagg gaatcgactt caaggaggac ggcaacatcc tgggccacaa gctggagtac     1680

aattacaact cccacaacgt gtatatcatg gccgataaac agaagaatgg aatcaaagtc     1740

aatttcaaga tcaggcacaa tatcgaggac ggcagcgtcc aactggccga ccactatcag     1800

cagaataccc ccattggaga cggacccgtg ctgctccccg acaaccacta cctctccaca     1860

cagtccgctc tgtccaagga ccccaacgag aagagggacc atatggtcct gctggaattc     1920

gtgaccgccg ctggcatcac cctcggcatg gatgagctgt acaagggagg aggaggcagc     1980

ggaggaggcg gaagcgcctc gagcgacaga agttataaaa gtcaatattt gaacaatggc     2040

cctcagcgga ttggtaggaa gtacaaaaaa gtccgattta tggcatacac agatgaaacc     2100

tttaagactc gtgaagctat tcagcatgaa tcaggaatct tgggaccttt actttatggg     2160

gaagttggag acacactgtt gattatattt aagaatcaag caagcagacc atataacatc     2220

taccctcacg gaatcactga tgtccgtcct ttgtattcaa ggagattacc aaaaggtgta     2280

aaacatttga aggattttcc aattctgcca ggagaaatat tcaaatataa atggacagtg     2340

actgtagaag atgggccaac taaatcagat cctcggtgcc tgacccgcta ttactctagt     2400

ttcgttaata tggagagaga tctagcttca ggactcattg gccctctcct catctgctac     2460

aaagaatctg tagatcaaag aggaaaccag ataatgtcag acaagaggaa tgtcatcctg     2520

ttttctgtat ttgatgagaa ccgaagctgg tacctcacag agaatataca acgctttctc     2580

cccaatccag ctggagtgca gcttgaggat ccagagttcc aagcctccaa catcatgcac     2640

agcatcaatg gctatgtttt tgatagtttg cagttgtcag tttgtttgca tgaggtggca     2700

tactggtaca ttctaagcat tggagcacag actgacttcc tttctgtctt cttctctgga     2760

tataccttca aacacaaaat ggtctatgaa gacacactca ccctattccc attctcagga     2820

gaaactgtct tcatgtcgat ggaaaaccca ggtctatgga ttctggggtg ccacaactca     2880

gactttcgga acagaggcat gaccgcctta ctgaaggttt ctagttgtga caagaacact     2940

ggtgattatt acgaggacag ttatgaagat atttcagcat acttgctgag taaaaacaat     3000

gccattgaac caagaagctt ctctcaaaac ccaccagtct tgaaacgcca tcaacgggaa     3060

ataactcgta ctactcttca gtcagatcaa gaggaaatcg attatgatga taccatatca     3120

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     3180

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     3240

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     3300

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     3360

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     3420

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     3480

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     3540

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     3600

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3660

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3720

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3780

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3840

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3900

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3960

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     4020

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     4080

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     4140

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     4200

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     4260

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     4320

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     4380

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     4440

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     4500

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     4560

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     4620

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4680

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4740

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4800

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4860

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4920

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4980

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     5040

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     5100

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     5160

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        5202


<210>  182
<211>  1734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0403-EGFP1 DNA SEQUENCE

<400>  182

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Gly Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            420                 425                 430         


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        435                 440                 445             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    450                 455                 460                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
465                 470                 475                 480 


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
                485                 490                 495     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
            500                 505                 510         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        515                 520                 525             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    530                 535                 540                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
545                 550                 555                 560 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
                565                 570                 575     


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
            580                 585                 590         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        595                 600                 605             


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
    610                 615                 620                 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
625                 630                 635                 640 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Asp Arg Ser Tyr 
            660                 665                 670         


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
        675                 680                 685             


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
    690                 695                 700                 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
705                 710                 715                 720 


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
                725                 730                 735     


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
            740                 745                 750         


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
        755                 760                 765             


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
    770                 775                 780                 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
785                 790                 795                 800 


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
                805                 810                 815     


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
            820                 825                 830         


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
        835                 840                 845             


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
    850                 855                 860                 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
865                 870                 875                 880 


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
                885                 890                 895     


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
            900                 905                 910         


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
        915                 920                 925             


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
    930                 935                 940                 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
945                 950                 955                 960 


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
                965                 970                 975     


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
            980                 985                 990         


Ala Tyr Leu Leu Ser Lys Asn Asn  Ala Ile Glu Pro Arg  Ser Phe Ser 
        995                 1000                 1005             


Gln Asn  Pro Pro Val Leu Lys  Arg His Gln Arg Glu  Ile Thr Arg 
    1010                 1015                 1020             


Thr Thr  Leu Gln Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 
    1025                 1030                 1035             


Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 
    1040                 1045                 1050             


Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 
    1055                 1060                 1065             


Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 
    1070                 1075                 1080             


Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 
    1085                 1090                 1095             


Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 
    1100                 1105                 1110             


Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 
    1130                 1135                 1140             


Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 
    1145                 1150                 1155             


Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 
    1160                 1165                 1170             


Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1175                 1180                 1185             


Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 
    1190                 1195                 1200             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 
    1205                 1210                 1215             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 
    1220                 1225                 1230             


Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 
    1235                 1240                 1245             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1250                 1255                 1260             


Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 
    1265                 1270                 1275             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1280                 1285                 1290             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1295                 1300                 1305             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1310                 1315                 1320             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1325                 1330                 1335             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1340                 1345                 1350             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1355                 1360                 1365             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1370                 1375                 1380             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1385                 1390                 1395             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1400                 1405                 1410             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1415                 1420                 1425             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1430                 1435                 1440             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1445                 1450                 1455             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1460                 1465                 1470             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1475                 1480                 1485             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1490                 1495                 1500             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1505                 1510                 1515             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1520                 1525                 1530             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1535                 1540                 1545             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1550                 1555                 1560             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1565                 1570                 1575             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1580                 1585                 1590             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1595                 1600                 1605             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1610                 1615                 1620             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1625                 1630                 1635             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1640                 1645                 1650             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1655                 1660                 1665             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1670                 1675                 1680             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1685                 1690                 1695             


Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro Gly Ala  Glu Thr Ala 
    1700                 1705                 1710             


Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu Ser Pro  Ala Thr Gly 
    1715                 1720                 1725             


His His  His His His His 
    1730                 


<210>  183
<211>  5202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-EGFP1 DNA SEQUENCE

<400>  183
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagggcg cgccgggcgg aggaggaagc ggaggcggag gctccatggt gagcaagggc     2340

gaagagctgt tcaccggcgt ggtgcccatc ctcgtggaac tggacggcga tgtcaacggc     2400

cacaagttca gcgtcagcgg agagggagaa ggcgacgcca cctacggcaa gctcaccctg     2460

aagttcatct gtaccaccgg caagctgcct gtgccctggc ctacactggt gaccaccctg     2520

acctatggag tgcagtgctt tagcaggtac cccgaccaca tgaagcagca cgactttttc     2580

aagagcgcca tgcctgaagg ctacgtgcag gagaggacca tcttcttcaa agacgacggc     2640

aactacaaga ccagggccga ggtcaagttc gagggcgata ccctcgtgaa caggatcgag     2700

ctgaagggaa tcgacttcaa ggaggacggc aacatcctgg gccacaagct ggagtacaat     2760

tacaactccc acaacgtgta tatcatggcc gataaacaga agaatggaat caaagtcaat     2820

ttcaagatca ggcacaatat cgaggacggc agcgtccaac tggccgacca ctatcagcag     2880

aataccccca ttggagacgg acccgtgctg ctccccgaca accactacct ctccacacag     2940

tccgctctgt ccaaggaccc caacgagaag agggaccata tggtcctgct ggaattcgtg     3000

accgccgctg gcatcaccct cggcatggat gagctgtaca agggaggagg aggcagcgga     3060

ggaggcggaa gcgcctcgag ctcagatcaa gaggaaatcg attatgatga taccatatca     3120

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc     3180

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat     3240

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag     3300

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt     3360

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat     3420

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt     3480

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct     3540

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag     3600

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca     3660

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga     3720

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg     3780

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat     3840

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3900

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3960

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     4020

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     4080

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     4140

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     4200

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     4260

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     4320

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     4380

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     4440

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     4500

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     4560

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     4620

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4680

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4740

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4800

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4860

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4920

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4980

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     5040

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     5100

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     5160

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        5202


<210>  184
<211>  1734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1656-EGFP1 PROTEIN SEQUENCE

<400>  184

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Gly Ala Pro Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
    770                 775                 780                 


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
785                 790                 795                 800 


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
                805                 810                 815     


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
            820                 825                 830         


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
        835                 840                 845             


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
    850                 855                 860                 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
865                 870                 875                 880 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
                885                 890                 895     


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
            900                 905                 910         


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
        915                 920                 925             


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
    930                 935                 940                 


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
945                 950                 955                 960 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
                965                 970                 975     


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
            980                 985                 990         


His Met Val Leu Leu Glu Phe Val  Thr Ala Ala Gly Ile  Thr Leu Gly 
        995                 1000                 1005             


Met Asp  Glu Leu Tyr Lys Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1010                 1015                 1020             


Ser Ala  Ser Ser Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 
    1025                 1030                 1035             


Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 
    1040                 1045                 1050             


Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 
    1055                 1060                 1065             


Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 
    1070                 1075                 1080             


Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 
    1085                 1090                 1095             


Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 
    1100                 1105                 1110             


Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 
    1130                 1135                 1140             


Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 
    1145                 1150                 1155             


Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 
    1160                 1165                 1170             


Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1175                 1180                 1185             


Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 
    1190                 1195                 1200             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 
    1205                 1210                 1215             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 
    1220                 1225                 1230             


Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 
    1235                 1240                 1245             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1250                 1255                 1260             


Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 
    1265                 1270                 1275             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1280                 1285                 1290             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1295                 1300                 1305             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1310                 1315                 1320             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1325                 1330                 1335             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1340                 1345                 1350             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1355                 1360                 1365             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1370                 1375                 1380             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1385                 1390                 1395             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1400                 1405                 1410             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1415                 1420                 1425             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1430                 1435                 1440             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1445                 1450                 1455             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1460                 1465                 1470             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1475                 1480                 1485             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1490                 1495                 1500             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1505                 1510                 1515             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1520                 1525                 1530             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1535                 1540                 1545             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1550                 1555                 1560             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1565                 1570                 1575             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1580                 1585                 1590             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1595                 1600                 1605             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1610                 1615                 1620             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1625                 1630                 1635             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1640                 1645                 1650             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1655                 1660                 1665             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1670                 1675                 1680             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1685                 1690                 1695             


Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro Gly Ala  Glu Thr Ala 
    1700                 1705                 1710             


Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu Ser Pro  Ala Thr Gly 
    1715                 1720                 1725             


His His  His His His His 
    1730                 


<210>  185
<211>  5211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-EGFP1 DNA SEQUENCE

<400>  185
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagggc gcgccgggcg gaggaggaag cggaggcgga     2520

ggctccatgg tgagcaaggg cgaagagctg ttcaccggcg tggtgcccat cctcgtggaa     2580

ctggacggcg atgtcaacgg ccacaagttc agcgtcagcg gagagggaga aggcgacgcc     2640

acctacggca agctcaccct gaagttcatc tgtaccaccg gcaagctgcc tgtgccctgg     2700

cctacactgg tgaccaccct gacctatgga gtgcagtgct ttagcaggta ccccgaccac     2760

atgaagcagc acgacttttt caagagcgcc atgcctgaag gctacgtgca ggagaggacc     2820

atcttcttca aagacgacgg caactacaag accagggccg aggtcaagtt cgagggcgat     2880

accctcgtga acaggatcga gctgaaggga atcgacttca aggaggacgg caacatcctg     2940

ggccacaagc tggagtacaa ttacaactcc cacaacgtgt atatcatggc cgataaacag     3000

aagaatggaa tcaaagtcaa tttcaagatc aggcacaata tcgaggacgg cagcgtccaa     3060

ctggccgacc actatcagca gaataccccc attggagacg gacccgtgct gctccccgac     3120

aaccactacc tctccacaca gtccgctctg tccaaggacc ccaacgagaa gagggaccat     3180

atggtcctgc tggaattcgt gaccgccgct ggcatcaccc tcggcatgga tgagctgtac     3240

aagggaggag gaggcagcgg aggaggcgga agcgcctcga gcagggctca gagtggcagt     3300

gtccctcagt tcaagaaagt tgttttccag gaatttactg atggctcctt tactcagccc     3360

ttataccgtg gagaactaaa tgaacatttg ggactcctgg ggccatatat aagagcagaa     3420

gttgaagata atatcatggt aactttcaga aatcaggcct ctcgtcccta ttccttctat     3480

tctagcctta tttcttatga ggaagatcag aggcaaggag cagaacctag aaaaaacttt     3540

gtcaagccta atgaaaccaa aacttacttt tggaaagtgc aacatcatat ggcacccact     3600

aaagatgagt ttgactgcaa agcctgggct tatttctctg atgttgacct ggaaaaagat     3660

gtgcactcag gcctgattgg accccttctg gtctgccaca ctaacacact gaaccctgct     3720

catgggagac aagtgacagt acaggaattt gctctgtttt tcaccatctt tgatgagacc     3780

aaaagctggt acttcactga aaatatggaa agaaactgca gggctccctg caatatccag     3840

atggaagatc ccacttttaa agagaattat cgcttccatg caatcaatgg ctacataatg     3900

gatacactac ctggcttagt aatggctcag gatcaaagga ttcgatggta tctgctcagc     3960

atgggcagca atgaaaacat ccattctatt catttcagtg gacatgtgtt cactgtacga     4020

aaaaaagagg agtataaaat ggcactgtac aatctctatc caggtgtttt tgagacagtg     4080

gaaatgttac catccaaagc tggaatttgg cgggtggaat gccttattgg cgagcatcta     4140

catgctggga tgagcacact ttttctggtg tacagcaata agtgtcagac tcccctggga     4200

atggcttctg gacacattag agattttcag attacagctt caggacaata tggacagtgg     4260

gccccaaagc tggccagact tcattattcc ggatcaatca atgcctggag caccaaggag     4320

cccttttctt ggatcaaggt ggatctgttg gcaccaatga ttattcacgg catcaagacc     4380

cagggtgccc gtcagaagtt ctccagcctc tacatctctc agtttatcat catgtatagt     4440

cttgatggga agaagtggca gacttatcga ggaaattcca ctggaacctt aatggtcttc     4500

tttggcaatg tggattcatc tgggataaaa cacaatattt ttaaccctcc aattattgct     4560

cgatacatcc gtttgcaccc aactcattat agcattcgca gcactcttcg catggagttg     4620

atgggctgtg atttaaatag ttgcagcatg ccattgggaa tggagagtaa agcaatatca     4680

gatgcacaga ttactgcttc atcctacttt accaatatgt ttgccacctg gtctccttca     4740

aaagctcgac ttcacctcca agggaggagt aatgcctgga gacctcaggt gaataatcca     4800

aaagagtggc tgcaagtgga cttccagaag acaatgaaag tcacaggagt aactactcag     4860

ggagtaaaat ctctgcttac cagcatgtat gtgaaggagt tcctcatctc cagcagtcaa     4920

gatggccatc agtggactct cttttttcag aatggcaaag taaaggtttt tcagggaaat     4980

caagactcct tcacacctgt ggtgaactct ctagacccac cgttactgac tcgctacctt     5040

cgaattcacc cccagagttg ggtgcaccag attgccctga ggatggaggt tctgggctgc     5100

gaggcacagg acctctacgg cgccggatca cctggggccg aaacggccga acaaaaactc     5160

atctcagaag aggatctgtc acctgcaacc ggtcatcatc accatcacca t              5211


<210>  186
<211>  1737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1720-EGFP1 PROTEIN SEQUENCE

<400>  186

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Gly Ala Pro 
            820                 825                 830         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Val Ser Lys Gly Glu 
        835                 840                 845             


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
    850                 855                 860                 


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
865                 870                 875                 880 


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
                885                 890                 895     


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
            900                 905                 910         


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
        915                 920                 925             


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
    930                 935                 940                 


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
945                 950                 955                 960 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
                965                 970                 975     


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
            980                 985                 990         


Val Tyr Ile Met Ala Asp Lys Gln  Lys Asn Gly Ile Lys  Val Asn Phe 
        995                 1000                 1005             


Lys Ile  Arg His Asn Ile Glu  Asp Gly Ser Val Gln  Leu Ala Asp 
    1010                 1015                 1020             


His Tyr  Gln Gln Asn Thr Pro  Ile Gly Asp Gly Pro  Val Leu Leu 
    1025                 1030                 1035             


Pro Asp  Asn His Tyr Leu Ser  Thr Gln Ser Ala Leu  Ser Lys Asp 
    1040                 1045                 1050             


Pro Asn  Glu Lys Arg Asp His  Met Val Leu Leu Glu  Phe Val Thr 
    1055                 1060                 1065             


Ala Ala  Gly Ile Thr Leu Gly  Met Asp Glu Leu Tyr  Lys Gly Gly 
    1070                 1075                 1080             


Gly Gly  Ser Gly Gly Gly Gly  Ser Ala Ser Ser Arg  Ala Gln Ser 
    1085                 1090                 1095             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1100                 1105                 1110             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1115                 1120                 1125             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1130                 1135                 1140             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1145                 1150                 1155             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1160                 1165                 1170             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1175                 1180                 1185             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1190                 1195                 1200             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1205                 1210                 1215             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1220                 1225                 1230             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1235                 1240                 1245             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1250                 1255                 1260             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1265                 1270                 1275             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1280                 1285                 1290             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1295                 1300                 1305             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1310                 1315                 1320             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1325                 1330                 1335             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1340                 1345                 1350             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    1355                 1360                 1365             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    1370                 1375                 1380             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    1385                 1390                 1395             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    1400                 1405                 1410             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    1415                 1420                 1425             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    1430                 1435                 1440             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    1445                 1450                 1455             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    1460                 1465                 1470             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    1475                 1480                 1485             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    1490                 1495                 1500             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    1505                 1510                 1515             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    1520                 1525                 1530             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    1535                 1540                 1545             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    1550                 1555                 1560             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    1565                 1570                 1575             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    1580                 1585                 1590             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    1595                 1600                 1605             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    1610                 1615                 1620             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    1625                 1630                 1635             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    1640                 1645                 1650             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    1655                 1660                 1665             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    1670                 1675                 1680             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    1685                 1690                 1695             


Gly Cys  Glu Ala Gln Asp Leu  Tyr Gly Ala Gly Ser  Pro Gly Ala 
    1700                 1705                 1710             


Glu Thr  Ala Glu Gln Lys Leu  Ile Ser Glu Glu Asp  Leu Ser Pro 
    1715                 1720                 1725             


Ala Thr  Gly His His His His  His His 
    1730                 1735         


<210>  187
<211>  5202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-EGFP1 DNA SEQUENCE

<400>  187
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg ctagcttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aatcgattat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggg cgcgccgggc ggaggaggaa gcggaggcgg aggctccatg     3060

gtgagcaagg gcgaagagct gttcaccggc gtggtgccca tcctcgtgga actggacggc     3120

gatgtcaacg gccacaagtt cagcgtcagc ggagagggag aaggcgacgc cacctacggc     3180

aagctcaccc tgaagttcat ctgtaccacc ggcaagctgc ctgtgccctg gcctacactg     3240

gtgaccaccc tgacctatgg agtgcagtgc tttagcaggt accccgacca catgaagcag     3300

cacgactttt tcaagagcgc catgcctgaa ggctacgtgc aggagaggac catcttcttc     3360

aaagacgacg gcaactacaa gaccagggcc gaggtcaagt tcgagggcga taccctcgtg     3420

aacaggatcg agctgaaggg aatcgacttc aaggaggacg gcaacatcct gggccacaag     3480

ctggagtaca attacaactc ccacaacgtg tatatcatgg ccgataaaca gaagaatgga     3540

atcaaagtca atttcaagat caggcacaat atcgaggacg gcagcgtcca actggccgac     3600

cactatcagc agaatacccc cattggagac ggacccgtgc tgctccccga caaccactac     3660

ctctccacac agtccgctct gtccaaggac cccaacgaga agagggacca tatggtcctg     3720

ctggaattcg tgaccgccgc tggcatcacc ctcggcatgg atgagctgta caagggagga     3780

ggaggcagcg gaggaggcgg aagcgcctcg agcgctccct gcaatatcca gatggaagat     3840

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta     3900

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc     3960

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag     4020

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta     4080

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg     4140

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct     4200

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag     4260

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct     4320

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc     4380

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg     4440

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat     4500

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc     4560

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt     4620

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag     4680

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga     4740

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg     4800

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa     4860

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat     4920

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc     4980

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac     5040

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag     5100

gacctctacg gcgccggatc acctggggcc gaaacggccg aacaaaaact catctcagaa     5160

gaggatctgt cacctgcaac cggtcatcat caccatcacc at                        5202


<210>  188
<211>  1734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-1900-EGFP1 PROTEIN SEQUENCE

<400>  188

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Gly Ala 
        995                 1000                 1005             


Pro Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Met  Val Ser Lys 
    1010                 1015                 1020             


Gly Glu  Glu Leu Phe Thr Gly  Val Val Pro Ile Leu  Val Glu Leu 
    1025                 1030                 1035             


Asp Gly  Asp Val Asn Gly His  Lys Phe Ser Val Ser  Gly Glu Gly 
    1040                 1045                 1050             


Glu Gly  Asp Ala Thr Tyr Gly  Lys Leu Thr Leu Lys  Phe Ile Cys 
    1055                 1060                 1065             


Thr Thr  Gly Lys Leu Pro Val  Pro Trp Pro Thr Leu  Val Thr Thr 
    1070                 1075                 1080             


Leu Thr  Tyr Gly Val Gln Cys  Phe Ser Arg Tyr Pro  Asp His Met 
    1085                 1090                 1095             


Lys Gln  His Asp Phe Phe Lys  Ser Ala Met Pro Glu  Gly Tyr Val 
    1100                 1105                 1110             


Gln Glu  Arg Thr Ile Phe Phe  Lys Asp Asp Gly Asn  Tyr Lys Thr 
    1115                 1120                 1125             


Arg Ala  Glu Val Lys Phe Glu  Gly Asp Thr Leu Val  Asn Arg Ile 
    1130                 1135                 1140             


Glu Leu  Lys Gly Ile Asp Phe  Lys Glu Asp Gly Asn  Ile Leu Gly 
    1145                 1150                 1155             


His Lys  Leu Glu Tyr Asn Tyr  Asn Ser His Asn Val  Tyr Ile Met 
    1160                 1165                 1170             


Ala Asp  Lys Gln Lys Asn Gly  Ile Lys Val Asn Phe  Lys Ile Arg 
    1175                 1180                 1185             


His Asn  Ile Glu Asp Gly Ser  Val Gln Leu Ala Asp  His Tyr Gln 
    1190                 1195                 1200             


Gln Asn  Thr Pro Ile Gly Asp  Gly Pro Val Leu Leu  Pro Asp Asn 
    1205                 1210                 1215             


His Tyr  Leu Ser Thr Gln Ser  Ala Leu Ser Lys Asp  Pro Asn Glu 
    1220                 1225                 1230             


Lys Arg  Asp His Met Val Leu  Leu Glu Phe Val Thr  Ala Ala Gly 
    1235                 1240                 1245             


Ile Thr  Leu Gly Met Asp Glu  Leu Tyr Lys Gly Gly  Gly Gly Ser 
    1250                 1255                 1260             


Gly Gly  Gly Gly Ser Ala Ser  Ser Ala Pro Cys Asn  Ile Gln Met 
    1265                 1270                 1275             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1280                 1285                 1290             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1295                 1300                 1305             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1310                 1315                 1320             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1325                 1330                 1335             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1340                 1345                 1350             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1355                 1360                 1365             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1370                 1375                 1380             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1385                 1390                 1395             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1400                 1405                 1410             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1415                 1420                 1425             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1430                 1435                 1440             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1445                 1450                 1455             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1460                 1465                 1470             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1475                 1480                 1485             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1490                 1495                 1500             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1505                 1510                 1515             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1520                 1525                 1530             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1535                 1540                 1545             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1550                 1555                 1560             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1565                 1570                 1575             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1580                 1585                 1590             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1595                 1600                 1605             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1610                 1615                 1620             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1625                 1630                 1635             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1640                 1645                 1650             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1655                 1660                 1665             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1670                 1675                 1680             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1685                 1690                 1695             


Ala Gln  Asp Leu Tyr Gly Ala  Gly Ser Pro Gly Ala  Glu Thr Ala 
    1700                 1705                 1710             


Glu Gln  Lys Leu Ile Ser Glu  Glu Asp Leu Ser Pro  Ala Thr Gly 
    1715                 1720                 1725             


His His  His His His His 
    1730                 


<210>  189
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-CCP1 DNA SEQUENCE

<400>  189
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtggg cgcgccggga ggaggcggct ccggcggagg aggaagcggc      120

ggaggaggca gcggaggctg cggctccggc ggcggcggca gcggcggcgg aggcagcgga      180

ggcggcggca gcgcctcgag cgacgcaaga tttcctccta gagtgccaaa atcttttcca      240

ttcaacacct cagtcgtgta caaaaagact ctgtttgtag aattcacgga tcaccttttc      300

aacatcgcta agccaaggcc accctggatg ggtctgctag gtcctaccat ccaggctgag      360

gtttatgata cagtggtcat tacacttaag aacatggctt cccatcctgt cagtcttcat      420

gctgttggtg tatcctactg gaaagcttct gagggagctg aatatgatga tcagaccagt      480

caaagggaga aagaagatga taaagtcttc cctggtggaa gccatacata tgtctggcag      540

gtcctgaaag agaatggtcc aatggcctct gacccactgt gccttaccta ctcatatctt      600

tctcatgtgg acctggtaaa agacttgaat tcaggcctca ttggagccct actagtatgt      660

agagaaggga gtctggccaa ggaaaagaca cagaccttgc acaaatttat actacttttt      720

gctgtatttg atgaagggaa aagttggcac tcagaaacaa agaactcctt gatgcaggat      780

agggatgctg catctgctcg ggcctggcct aaaatgcaca cagtcaatgg ttatgtaaac      840

aggtctctgc caggtctgat tggatgccac aggaaatcag tctattggca tgtgattgga      900

atgggcacca ctcctgaagt gcactcaata ttcctcgaag gtcacacatt tcttgtgagg      960

aaccatcgcc aggctagctt ggaaatctcg ccaataactt tccttactgc tcaaacactc     1020

ttgatggacc ttggacagtt tctactgttt tgtcatatct cttcccacca acatgatggc     1080

atggaagctt atgtcaaagt agacagctgt ccagaggaac cccaactacg aatgaaaaat     1140

aatgaagaag cggaagacta tgatgatgat cttactgatt ctgaaatgga tgtggtcagg     1200

tttgatgatg acaactctcc ttcctttatc caaattcgct cagttgccaa gaagcatcct     1260

aaaacttggg tacattacat tgctgctgaa gaggaggact gggactatgc tcccttagtc     1320

ctcgcccccg atgacagaag ttataaaagt caatatttga acaatggccc tcagcggatt     1380

ggtaggaagt acaaaaaagt ccgatttatg gcatacacag atgaaacctt taagactcgt     1440

gaagctattc agcatgaatc aggaatcttg ggacctttac tttatgggga agttggagac     1500

acactgttga ttatatttaa gaatcaagca agcagaccat ataacatcta ccctcacgga     1560

atcactgatg tccgtccttt gtattcaagg agattaccaa aaggtgtaaa acatttgaag     1620

gattttccaa ttctgccagg agaaatattc aaatataaat ggacagtgac tgtagaagat     1680

gggccaacta aatcagatcc tcggtgcctg acccgctatt actctagttt cgttaatatg     1740

gagagagatc tagcttcagg actcattggc cctctcctca tctgctacaa agaatctgta     1800

gatcaaagag gaaaccagat aatgtcagac aagaggaatg tcatcctgtt ttctgtattt     1860

gatgagaacc gaagctggta cctcacagag aatatacaac gctttctccc caatccagct     1920

ggagtgcagc ttgaggatcc agagttccaa gcctccaaca tcatgcacag catcaatggc     1980

tatgtttttg atagtttgca gttgtcagtt tgtttgcatg aggtggcata ctggtacatt     2040

ctaagcattg gagcacagac tgacttcctt tctgtcttct tctctggata taccttcaaa     2100

cacaaaatgg tctatgaaga cacactcacc ctattcccat tctcaggaga aactgtcttc     2160

atgtcgatgg aaaacccagg tctatggatt ctggggtgcc acaactcaga ctttcggaac     2220

agaggcatga ccgccttact gaaggtttct agttgtgaca agaacactgg tgattattac     2280

gaggacagtt atgaagatat ttcagcatac ttgctgagta aaaacaatgc cattgaacca     2340

agaagcttct ctcaaaaccc accagtcttg aaacgccatc aacgggaaat aactcgtact     2400

actcttcagt cagatcaaga ggaaatcgat tatgatgata ccatatcagt tgaaatgaag     2460

aaggaagatt ttgacattta tgatgaggat gaaaatcaga gcccccgcag ctttcaaaag     2520

aaaacacgac actattttat tgctgcagtg gagaggctct gggattatgg gatgagtagc     2580

tccccacatg ttctaagaaa cagggctcag agtggcagtg tccctcagtt caagaaagtt     2640

gttttccagg aatttactga tggctccttt actcagccct tataccgtgg agaactaaat     2700

gaacatttgg gactcctggg gccatatata agagcagaag ttgaagataa tatcatggta     2760

actttcagaa atcaggcctc tcgtccctat tccttctatt ctagccttat ttcttatgag     2820

gaagatcaga ggcaaggagc agaacctaga aaaaactttg tcaagcctaa tgaaaccaaa     2880

acttactttt ggaaagtgca acatcatatg gcacccacta aagatgagtt tgactgcaaa     2940

gcctgggctt atttctctga tgttgacctg gaaaaagatg tgcactcagg cctgattgga     3000

ccccttctgg tctgccacac taacacactg aaccctgctc atgggagaca agtgacagta     3060

caggaatttg ctctgttttt caccatcttt gatgagacca aaagctggta cttcactgaa     3120

aatatggaaa gaaactgcag ggctccctgc aatatccaga tggaagatcc cacttttaaa     3180

gagaattatc gcttccatgc aatcaatggc tacataatgg atacactacc tggcttagta     3240

atggctcagg atcaaaggat tcgatggtat ctgctcagca tgggcagcaa tgaaaacatc     3300

cattctattc atttcagtgg acatgtgttc actgtacgaa aaaaagagga gtataaaatg     3360

gcactgtaca atctctatcc aggtgttttt gagacagtgg aaatgttacc atccaaagct     3420

ggaatttggc gggtggaatg ccttattggc gagcatctac atgctgggat gagcacactt     3480

tttctggtgt acagcaataa gtgtcagact cccctgggaa tggcttctgg acacattaga     3540

gattttcaga ttacagcttc aggacaatat ggacagtggg ccccaaagct ggccagactt     3600

cattattccg gatcaatcaa tgcctggagc accaaggagc ccttttcttg gatcaaggtg     3660

gatctgttgg caccaatgat tattcacggc atcaagaccc agggtgcccg tcagaagttc     3720

tccagcctct acatctctca gtttatcatc atgtatagtc ttgatgggaa gaagtggcag     3780

acttatcgag gaaattccac tggaacctta atggtcttct ttggcaatgt ggattcatct     3840

gggataaaac acaatatttt taaccctcca attattgctc gatacatccg tttgcaccca     3900

actcattata gcattcgcag cactcttcgc atggagttga tgggctgtga tttaaatagt     3960

tgcagcatgc cattgggaat ggagagtaaa gcaatatcag atgcacagat tactgcttca     4020

tcctacttta ccaatatgtt tgccacctgg tctccttcaa aagctcgact tcacctccaa     4080

gggaggagta atgcctggag acctcaggtg aataatccaa aagagtggct gcaagtggac     4140

ttccagaaga caatgaaagt cacaggagta actactcagg gagtaaaatc tctgcttacc     4200

agcatgtatg tgaaggagtt cctcatctcc agcagtcaag atggccatca gtggactctc     4260

ttttttcaga atggcaaagt aaaggttttt cagggaaatc aagactcctt cacacctgtg     4320

gtgaactctc tagacccacc gttactgact cgctaccttc gaattcaccc ccagagttgg     4380

gtgcaccaga ttgccctgag gatggaggtt ctgggctgcg aggcacagga cctctacggc     4440

gccggatcac ctggggccga aacggccgaa caaaaactca tctcagaaga ggatctgtca     4500

cctgcaaccg gtcatcatca ccatcaccat                                      4530


<210>  190
<211>  1510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-0026-CCP1 PROTEIN SEQUENCE

<400>  190

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Gly Ala Pro Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Cys Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Ala Ser Ser Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro 
65                  70                  75                  80  


Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr 
                85                  90                  95      


Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu 
            100                 105                 110         


Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr 
        115                 120                 125             


Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val 
    130                 135                 140                 


Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser 
145                 150                 155                 160 


Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr 
                165                 170                 175     


Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro 
            180                 185                 190         


Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp 
        195                 200                 205             


Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser 
    210                 215                 220                 


Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe 
225                 230                 235                 240 


Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser 
                245                 250                 255     


Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met 
            260                 265                 270         


His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly 
        275                 280                 285             


Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr 
    290                 295                 300                 


Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg 
305                 310                 315                 320 


Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr 
                325                 330                 335     


Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His 
            340                 345                 350         


Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp 
        355                 360                 365             


Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala 
    370                 375                 380                 


Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg 
385                 390                 395                 400 


Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala 
                405                 410                 415     


Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu 
            420                 425                 430         


Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr 
        435                 440                 445             


Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
    450                 455                 460                 


Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg 
465                 470                 475                 480 


Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly 
                485                 490                 495     


Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
            500                 505                 510         


Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr 
        515                 520                 525             


Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile 
    530                 535                 540                 


Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
                565                 570                 575     


Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu 
            580                 585                 590         


Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met 
        595                 600                 605             


Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg 
    610                 615                 620                 


Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala 
625                 630                 635                 640 


Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His 
                645                 650                 655     


Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu 
            660                 665                 670         


His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp 
        675                 680                 685             


Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val 
    690                 695                 700                 


Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe 
705                 710                 715                 720 


Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser 
                725                 730                 735     


Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys 
            740                 745                 750         


Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser 
        755                 760                 765             


Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
    770                 775                 780                 


Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
785                 790                 795                 800 


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
                805                 810                 815     


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
            820                 825                 830         


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
        835                 840                 845             


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
    850                 855                 860                 


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
865                 870                 875                 880 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
                885                 890                 895     


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
            900                 905                 910         


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
        915                 920                 925             


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
    930                 935                 940                 


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
945                 950                 955                 960 


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
                965                 970                 975     


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
            980                 985                 990         


Asp Val His Ser Gly Leu Ile Gly  Pro Leu Leu Val Cys  His Thr Asn 
        995                 1000                 1005             


Thr Leu  Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
    1010                 1015                 1020             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1025                 1030                 1035             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1040                 1045                 1050             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1055                 1060                 1065             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1070                 1075                 1080             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1085                 1090                 1095             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1100                 1105                 1110             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1115                 1120                 1125             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1130                 1135                 1140             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1145                 1150                 1155             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1160                 1165                 1170             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1175                 1180                 1185             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1190                 1195                 1200             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1205                 1210                 1215             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1220                 1225                 1230             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1235                 1240                 1245             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1265                 1270                 1275             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1280                 1285                 1290             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1295                 1300                 1305             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1310                 1315                 1320             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1325                 1330                 1335             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1340                 1345                 1350             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1355                 1360                 1365             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1370                 1375                 1380             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1385                 1390                 1395             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1400                 1405                 1410             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1415                 1420                 1425             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1430                 1435                 1440             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1445                 1450                 1455             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1460                 1465                 1470             


Glu Ala  Gln Asp Leu Tyr Gly  Ala Gly Ser Pro Gly  Ala Glu Thr 
    1475                 1480                 1485             


Ala Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Ser  Pro Ala Thr 
    1490                 1495                 1500             


Gly His  His His His His His  
    1505                 1510 


<210>  191
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly4Ser linker

<400>  191

Gly Gly Gly Gly Ser 
1               5   


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=2

<400>  192

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  193
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=3

<400>  193

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  194
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=4

<400>  194

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  195
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=5

<400>  195

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  196
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=6

<400>  196

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  197
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=7

<400>  197

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  198
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=8

<400>  198

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  199
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=9

<400>  199

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  200
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker, n=10

<400>  200

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, GGGGS subsequence repeated n times, where 
       n= 1 to 400

<400>  201

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  202
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=1

<400>  202

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  203
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=2

<400>  203

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  204
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=3

<400>  204

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  205
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=4

<400>  205

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  206
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=5

<400>  206

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  207
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=6

<400>  207

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30      


<210>  208
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=7

<400>  208

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  209
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=8

<400>  209

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40      


<210>  210
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=9

<400>  210

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45      


<210>  211
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser(Gly4Ser)n linker, n=10

<400>  211

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


