                         SEQUENCE LISTING

<110>  Iyer, Shrivats M
       Delp, Scott L
       Montgomery, Kathryn L
       Deisseroth, Karl A
       Towne, Christopher
 
<120>  COMPOSITIONS AND METHODS FOR CONTROLLING PAIN

<130>  STAN-1055WO

<150>  US 61/865,962
<151>  2013-08-14

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  258
<212>  PRT
<213>  Halorubrum sodomense

<400>  1

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp 
        


<210>  2
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Archaerhodopsin-3 from Halorubrum sodomense

<400>  2

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp Arg Pro Val Val Ala Ala Ala Ala Lys Ser Arg Ile Thr Ser 
            260                 265                 270         


Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Ser 
        275                 280                 285             


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
    290                 295                 300                 


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
305                 310                 315                 320 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
                325                 330                 335     


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
            340                 345                 350         


Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
        355                 360                 365             


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
    370                 375                 380                 


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
385                 390                 395                 400 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
                405                 410                 415     


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
            420                 425                 430         


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
        435                 440                 445             


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
    450                 455                 460                 


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
465                 470                 475                 480 


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp 
                485                 490                 495     


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
            500                 505                 510         


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu 
        515                 520                 525             


Asn Glu Val 
    530     


<210>  3
<211>  248
<212>  PRT
<213>  Halorubrum sp. TP009

<400>  3

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Ile Val Lys Gly Trp Gly Val Thr Asp Lys Glu 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ser Ile Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Ala Gly Glu Val Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Ser Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Pro Leu Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ala Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro 
                245             


<210>  4
<211>  223
<212>  PRT
<213>  Guillardia theta

<400>  4

Ala Ser Ser Phe Gly Lys Ala Leu Leu Glu Phe Val Phe Ile Val Phe 
1               5                   10                  15      


Ala Cys Ile Thr Leu Leu Leu Gly Ile Asn Ala Ala Lys Ser Lys Ala 
            20                  25                  30          


Ala Ser Arg Val Leu Phe Pro Ala Thr Phe Val Thr Gly Ile Ala Ser 
        35                  40                  45              


Ile Ala Tyr Phe Ser Met Ala Ser Gly Gly Gly Trp Val Ile Ala Pro 
    50                  55                  60                  


Asp Cys Arg Gln Leu Phe Val Ala Arg Tyr Leu Asp Trp Leu Ile Thr 
65                  70                  75                  80  


Thr Pro Leu Leu Leu Ile Asp Leu Gly Leu Val Ala Gly Val Ser Arg 
                85                  90                  95      


Trp Asp Ile Met Ala Leu Cys Leu Ser Asp Val Leu Met Ile Ala Thr 
            100                 105                 110         


Gly Ala Phe Gly Ser Leu Thr Val Gly Asn Val Lys Trp Val Trp Trp 
        115                 120                 125             


Phe Phe Gly Met Cys Trp Phe Leu His Ile Ile Phe Ala Leu Gly Lys 
    130                 135                 140                 


Ser Trp Ala Glu Ala Ala Lys Ala Lys Gly Gly Asp Ser Ala Ser Val 
145                 150                 155                 160 


Tyr Ser Lys Ile Ala Gly Ile Thr Val Ile Thr Trp Phe Cys Tyr Pro 
                165                 170                 175     


Val Val Trp Val Phe Ala Glu Gly Phe Gly Asn Phe Ser Val Thr Phe 
            180                 185                 190         


Glu Val Leu Ile Tyr Gly Val Leu Asp Val Ile Ser Lys Ala Val Phe 
        195                 200                 205             


Gly Leu Ile Leu Met Ser Gly Ala Ala Thr Gly Tyr Glu Ser Ile 
    210                 215                 220             


<210>  5
<211>  262
<212>  PRT
<213>  Oxyrrhis marina

<400>  5

Met Ala Pro Leu Ala Gln Asp Trp Thr Tyr Ala Glu Trp Ser Ala Val 
1               5                   10                  15      


Tyr Asn Ala Leu Ser Phe Gly Ile Ala Gly Met Gly Ser Ala Thr Ile 
            20                  25                  30          


Phe Phe Trp Leu Gln Leu Pro Asn Val Thr Lys Asn Tyr Arg Thr Ala 
        35                  40                  45              


Leu Thr Ile Thr Gly Ile Val Thr Leu Ile Ala Thr Tyr His Tyr Phe 
    50                  55                  60                  


Arg Ile Phe Asn Ser Trp Val Ala Ala Phe Asn Val Gly Leu Gly Val 
65                  70                  75                  80  


Asn Gly Ala Tyr Glu Val Thr Val Ser Gly Thr Pro Phe Asn Asp Ala 
                85                  90                  95      


Tyr Arg Tyr Val Asp Trp Leu Leu Thr Val Pro Leu Leu Leu Val Glu 
            100                 105                 110         


Leu Ile Leu Val Met Lys Leu Pro Ala Lys Glu Thr Val Cys Leu Ala 
        115                 120                 125             


Trp Thr Leu Gly Ile Ala Ser Ala Val Met Val Ala Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Glu Ile Gln Asp Asp Leu Ser Val Arg Trp Phe Trp Trp Ala Cys 
145                 150                 155                 160 


Ala Met Val Pro Phe Val Tyr Val Val Gly Thr Leu Val Val Gly Leu 
                165                 170                 175     


Gly Ala Ala Thr Ala Lys Gln Pro Glu Gly Val Val Asp Leu Val Ser 
            180                 185                 190         


Ala Ala Arg Tyr Leu Thr Val Val Ser Trp Leu Thr Tyr Pro Phe Val 
        195                 200                 205             


Tyr Ile Val Lys Asn Ile Gly Leu Ala Gly Ser Thr Ala Thr Met Tyr 
    210                 215                 220                 


Glu Gln Ile Gly Tyr Ser Ala Ala Asp Val Thr Ala Lys Ala Val Phe 
225                 230                 235                 240 


Gly Val Leu Ile Trp Ala Ile Ala Asn Ala Lys Ser Arg Leu Glu Glu 
                245                 250                 255     


Glu Gly Lys Leu Arg Ala 
            260         


<210>  6
<211>  313
<212>  PRT
<213>  Leptosphaeria maculans

<400>  6

Met Ile Val Asp Gln Phe Glu Glu Val Leu Met Lys Thr Ser Gln Leu 
1               5                   10                  15      


Phe Pro Leu Pro Thr Ala Thr Gln Ser Ala Gln Pro Thr His Val Ala 
            20                  25                  30          


Pro Val Pro Thr Val Leu Pro Asp Thr Pro Ile Tyr Glu Thr Val Gly 
        35                  40                  45              


Asp Ser Gly Ser Lys Thr Leu Trp Val Val Phe Val Leu Met Leu Ile 
    50                  55                  60                  


Ala Ser Ala Ala Phe Thr Ala Leu Ser Trp Lys Ile Pro Val Asn Arg 
65                  70                  75                  80  


Arg Leu Tyr His Val Ile Thr Thr Ile Ile Thr Leu Thr Ala Ala Leu 
                85                  90                  95      


Ser Tyr Phe Ala Met Ala Thr Gly His Gly Val Ala Leu Asn Lys Ile 
            100                 105                 110         


Val Ile Arg Thr Gln His Asp His Val Pro Asp Thr Tyr Glu Thr Val 
        115                 120                 125             


Tyr Arg Gln Val Tyr Tyr Ala Arg Tyr Ile Asp Trp Ala Ile Thr Thr 
    130                 135                 140                 


Pro Leu Leu Leu Leu Asp Leu Gly Leu Leu Ala Gly Met Ser Gly Ala 
145                 150                 155                 160 


His Ile Phe Met Ala Ile Val Ala Asp Leu Ile Met Val Leu Thr Gly 
                165                 170                 175     


Leu Phe Ala Ala Phe Gly Ser Glu Gly Thr Pro Gln Lys Trp Gly Trp 
            180                 185                 190         


Tyr Thr Ile Ala Cys Ile Ala Tyr Ile Phe Val Val Trp His Leu Val 
        195                 200                 205             


Leu Asn Gly Gly Ala Asn Ala Arg Val Lys Gly Glu Lys Leu Arg Ser 
    210                 215                 220                 


Phe Phe Val Ala Ile Gly Ala Tyr Thr Leu Ile Leu Trp Thr Ala Tyr 
225                 230                 235                 240 


Pro Ile Val Trp Gly Leu Ala Asp Gly Ala Arg Lys Ile Gly Val Asp 
                245                 250                 255     


Gly Glu Ile Ile Ala Tyr Ala Val Leu Asp Val Leu Ala Lys Gly Val 
            260                 265                 270         


Phe Gly Ala Trp Leu Leu Val Thr His Ala Asn Leu Arg Glu Ser Asp 
        275                 280                 285             


Val Glu Leu Asn Gly Phe Trp Ala Asn Gly Leu Asn Arg Glu Gly Ala 
    290                 295                 300                 


Ile Arg Ile Gly Glu Asp Asp Gly Ala 
305                 310             


<210>  7
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from L. maculans rhodopsin

<400>  7

Met Ile Val Asp Gln Phe Glu Glu Val Leu Met Lys Thr Ser Gln Leu 
1               5                   10                  15      


Phe Pro Leu Pro Thr Ala Thr Gln Ser Ala Gln Pro Thr His Val Ala 
            20                  25                  30          


Pro Val Pro Thr Val Leu Pro Asp Thr Pro Ile Tyr Glu Thr Val Gly 
        35                  40                  45              


Asp Ser Gly Ser Lys Thr Leu Trp Val Val Phe Val Leu Met Leu Ile 
    50                  55                  60                  


Ala Ser Ala Ala Phe Thr Ala Leu Ser Trp Lys Ile Pro Val Asn Arg 
65                  70                  75                  80  


Arg Leu Tyr His Val Ile Thr Thr Ile Ile Thr Leu Thr Ala Ala Leu 
                85                  90                  95      


Ser Tyr Phe Ala Met Ala Thr Gly His Gly Val Ala Leu Asn Lys Ile 
            100                 105                 110         


Val Ile Arg Thr Gln His Asp His Val Pro Asp Thr Tyr Glu Thr Val 
        115                 120                 125             


Tyr Arg Gln Val Tyr Tyr Ala Arg Tyr Ile Asp Trp Ala Ile Thr Thr 
    130                 135                 140                 


Pro Leu Leu Leu Leu Asp Leu Gly Leu Leu Ala Gly Met Ser Gly Ala 
145                 150                 155                 160 


His Ile Phe Met Ala Ile Val Ala Asp Leu Ile Met Val Leu Thr Gly 
                165                 170                 175     


Leu Phe Ala Ala Phe Gly Ser Glu Gly Thr Pro Gln Lys Trp Gly Trp 
            180                 185                 190         


Tyr Thr Ile Ala Cys Ile Ala Tyr Ile Phe Val Val Trp His Leu Val 
        195                 200                 205             


Leu Asn Gly Gly Ala Asn Ala Arg Val Lys Gly Glu Lys Leu Arg Ser 
    210                 215                 220                 


Phe Phe Val Ala Ile Gly Ala Tyr Thr Leu Ile Leu Trp Thr Ala Tyr 
225                 230                 235                 240 


Pro Ile Val Trp Gly Leu Ala Asp Gly Ala Arg Lys Ile Gly Val Asp 
                245                 250                 255     


Gly Glu Ile Ile Ala Tyr Ala Val Leu Asp Val Leu Ala Lys Gly Val 
            260                 265                 270         


Phe Gly Ala Trp Leu Leu Val Thr His Ala Asn Leu Arg Glu Ser Asp 
        275                 280                 285             


Val Glu Leu Asn Gly Phe Trp Ala Asn Gly Leu Asn Arg Glu Gly Ala 
    290                 295                 300                 


Ile Arg Ile Gly Glu Asp Asp Gly Ala Arg Pro Val Val Ala Val Ser 
305                 310                 315                 320 


Lys Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro 
                325                 330                 335     


Leu Asp Gln Ile Asp Ile Asn Val Val Ser Lys Gly Glu Glu Leu Phe 
            340                 345                 350         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        355                 360                 365             


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    370                 375                 380                 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
385                 390                 395                 400 


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala 
                405                 410                 415     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            420                 425                 430         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        435                 440                 445             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    450                 455                 460                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
465                 470                 475                 480 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                485                 490                 495     


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
            500                 505                 510         


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        515                 520                 525             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    530                 535                 540                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
545                 550                 555                 560 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                565                 570                 575     


Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
            580                 585                 


<210>  8
<211>  310
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  8

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  9
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii ChR2

<400>  9

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  10
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii ChR2

<400>  10

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Ala Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  11
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii and Volvox carteri 
       channelrhodopsins.

<400>  11

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  12
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii and Volvox carteri 
       channelrhodopsins.

<400>  12

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  13
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii and Volvox carteri 
       channelrhodopsins.

<400>  13

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  14
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Chlamydomonas reinhardtii and Volvox carteri 
       channelrhodopsins.

<400>  14

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  15
<211>  365
<212>  PRT
<213>  Dunaliella salina

<400>  15

Met Arg Arg Arg Glu Ser Gln Leu Ala Tyr Leu Cys Leu Phe Val Leu 
1               5                   10                  15      


Ile Ala Gly Trp Ala Pro Arg Leu Thr Glu Ser Ala Pro Asp Leu Ala 
            20                  25                  30          


Glu Arg Arg Pro Pro Ser Glu Arg Asn Thr Pro Tyr Ala Asn Ile Lys 
        35                  40                  45              


Lys Val Pro Asn Ile Thr Glu Pro Asn Ala Asn Val Gln Leu Asp Gly 
    50                  55                  60                  


Trp Ala Leu Tyr Gln Asp Phe Tyr Tyr Leu Ala Gly Ser Asp Lys Glu 
65                  70                  75                  80  


Trp Val Val Gly Pro Ser Asp Gln Cys Tyr Cys Arg Ala Trp Ser Lys 
                85                  90                  95      


Ser His Gly Thr Asp Arg Glu Gly Glu Ala Ala Val Val Trp Ala Tyr 
            100                 105                 110         


Ile Val Phe Ala Ile Cys Ile Val Gln Leu Val Tyr Phe Met Phe Ala 
        115                 120                 125             


Ala Trp Lys Ala Thr Val Gly Trp Glu Glu Val Tyr Val Asn Ile Ile 
    130                 135                 140                 


Glu Leu Val His Ile Ala Leu Val Ile Trp Val Glu Phe Asp Lys Pro 
145                 150                 155                 160 


Ala Met Leu Tyr Leu Asn Asp Gly Gln Met Val Pro Trp Leu Arg Tyr 
                165                 170                 175     


Ser Ala Trp Leu Leu Ser Cys Pro Val Ile Leu Ile His Leu Ser Asn 
            180                 185                 190         


Leu Thr Gly Leu Lys Gly Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
        195                 200                 205             


Val Ser Asp Ile Gly Thr Ile Val Phe Gly Thr Ser Ala Ala Leu Ala 
    210                 215                 220                 


Pro Pro Asn His Val Lys Val Ile Leu Phe Thr Ile Gly Leu Leu Tyr 
225                 230                 235                 240 


Gly Leu Phe Thr Phe Phe Thr Ala Ala Lys Val Tyr Ile Glu Ala Tyr 
                245                 250                 255     


His Thr Val Pro Lys Gly Gln Cys Arg Asn Leu Val Arg Ala Met Ala 
            260                 265                 270         


Trp Thr Tyr Phe Val Ser Trp Ala Met Phe Pro Ile Leu Phe Ile Leu 
        275                 280                 285             


Gly Arg Glu Gly Phe Gly His Ile Thr Tyr Phe Gly Ser Ser Ile Gly 
    290                 295                 300                 


His Phe Ile Leu Glu Ile Phe Ser Lys Asn Leu Trp Ser Leu Leu Gly 
305                 310                 315                 320 


His Gly Leu Arg Tyr Arg Ile Arg Gln His Ile Ile Ile His Gly Asn 
                325                 330                 335     


Leu Thr Lys Lys Asn Lys Ile Asn Ile Ala Gly Asp Asn Val Glu Val 
            340                 345                 350         


Glu Glu Tyr Val Asp Ser Asn Asp Lys Asp Ser Asp Val 
        355                 360                 365 


<210>  16
<211>  273
<212>  PRT
<213>  Natromonas pharaonis

<400>  16

Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro Leu Leu 
1               5                   10                  15      


Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser Ile Leu 
            20                  25                  30          


Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala Lys Leu 
        35                  40                  45              


Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala Ser Tyr 
    50                  55                  60                  


Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met Pro Ala 
65                  70                  75                  80  


Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu Glu Val 
                85                  90                  95      


Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala Leu Ser 
            100                 105                 110         


Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser Asn Ala 
        115                 120                 125             


Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys Val Thr 
    130                 135                 140                 


Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg Trp Phe 
145                 150                 155                 160 


Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr Ile Leu 
                165                 170                 175     


Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala Asp Met 
            180                 185                 190         


Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly Tyr Pro 
        195                 200                 205             


Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro Val Gly 
    210                 215                 220                 


Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys Tyr Ile 
225                 230                 235                 240 


Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser Val Val 
                245                 250                 255     


Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro Ala Asp 
            260                 265                 270         


Asp 
    


<210>  17
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Natromonas pharaonis NpHR

<400>  17

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro 
            20                  25                  30          


Leu Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala 
    50                  55                  60                  


Lys Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala 
65                  70                  75                  80  


Ser Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met 
                85                  90                  95      


Pro Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu 
            100                 105                 110         


Glu Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala 
        115                 120                 125             


Leu Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser 
    130                 135                 140                 


Asn Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys 
145                 150                 155                 160 


Val Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg 
                165                 170                 175     


Trp Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr 
            180                 185                 190         


Ile Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala 
        195                 200                 205             


Asp Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly 
    210                 215                 220                 


Tyr Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro 
225                 230                 235                 240 


Val Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys 
                245                 250                 255     


Tyr Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser 
            260                 265                 270         


Val Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Ala Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr 
    290                 295                 300                 


Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Ser Lys Gly Glu Glu 
305                 310                 315                 320 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                325                 330                 335     


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            340                 345                 350         


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
        355                 360                 365             


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
    370                 375                 380                 


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
385                 390                 395                 400 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
                405                 410                 415     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            420                 425                 430         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        435                 440                 445             


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
    450                 455                 460                 


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
465                 470                 475                 480 


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
                485                 490                 495     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            500                 505                 510         


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
        515                 520                 525             


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    530                 535                 540                 


Leu Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
545                 550                 555                 


<210>  18
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Natromonas pharaonis NpHR

<400>  18

Met Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro Leu 
1               5                   10                  15      


Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser Ile 
            20                  25                  30          


Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala Lys 
        35                  40                  45              


Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala Ser 
    50                  55                  60                  


Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met Pro 
65                  70                  75                  80  


Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu Glu 
                85                  90                  95      


Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala Leu 
            100                 105                 110         


Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser Asn 
        115                 120                 125             


Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys Val 
    130                 135                 140                 


Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg Trp 
145                 150                 155                 160 


Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr Ile 
                165                 170                 175     


Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala Asp 
            180                 185                 190         


Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly Tyr 
        195                 200                 205             


Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro Val 
    210                 215                 220                 


Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys Tyr 
225                 230                 235                 240 


Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser Val 
                245                 250                 255     


Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro Ala 
            260                 265                 270         


Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile 
        275                 280                 285             


Pro Leu Asp Gln Ile Asp Ile Asn Val Val Ser Lys Gly Glu Glu Leu 
    290                 295                 300                 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
305                 310                 315                 320 


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
                325                 330                 335     


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
            340                 345                 350         


Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe 
        355                 360                 365             


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
    370                 375                 380                 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
385                 390                 395                 400 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                405                 410                 415     


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
            420                 425                 430         


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
        435                 440                 445             


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
    450                 455                 460                 


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
465                 470                 475                 480 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                485                 490                 495     


Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            500                 505                 510         


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
        515                 520                 525             


Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
    530                 535                 540         


<210>  19
<211>  300
<212>  PRT
<213>  Volvox carteri

<400>  19

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  20
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Volvox carteri VChR1

<400>  20

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Ser Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  21
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from Volvox carteri VChR1

<400>  21

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Ala Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val 
            20  


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser 
            20                  25      


<210>  24
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Ala Gly His Ser Asn Ser Met Ala Leu Phe Ser Phe Ser Leu Leu 
1               5                   10                  15      


Trp Leu Cys Ser Gly Val Leu Gly Thr Glu Phe 
            20                  25          


<210>  25
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly 
            20              


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Arg Gly Thr Pro Leu Leu Leu Val Val Ser Leu Phe Ser Leu Leu 
1               5                   10                  15      


Gln Asp 
        


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Val Lys Glu Ser Leu 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Val Leu Gly Ser Leu 
1               5   


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser Lys 
1               5                   10                  15      


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Phe Xaa Tyr Glu Asn Glu 
1               5       


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu 
        


