                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  ANTIBODIES TO PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) AND USES 
       THEREOF

<130>  13-596-WO

<160>  147   

<170>  PatentIn version 3.5

<210>  1
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  1

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys 
65                  70                  75                  80  


Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu 
        115                 120                 125             


Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Arg Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  2
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 VH

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly Leu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Tyr Asp Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ile Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 VL

<400>  3

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Arg Leu Ile Ser Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Leu 
65                  70                  75                  80  


Ser Arg Val Glu Gly Ala Asp Leu Gly Val Tyr Tyr Cys Trp Gln Asp 
                85                  90                  95      


Arg His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp 
        115 


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 VH

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Asn Ile Tyr 
            20                  25                  30          


Trp Ile Gln Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Asp Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ile Gly Leu Arg Gly Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125 


<210>  5
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 VL

<400>  5

Asp Ile Gln Met Thr His Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Asn Ile Lys Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Phe Tyr Cys Gln His Arg Tyr Gly Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
            100                 105                 110 


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 VH

<400>  6

Glu Met Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 VL

<400>  7

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
            100                 105                 110 


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 VH

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Tyr Asn Leu Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 


<210>  9
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 VL

<400>  9

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Asp 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp 
        115 


<210>  10
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 VH

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Ser Val Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Gly Gln Gly Leu Asp Trp Ile Gly 
    50                  55                  60                  


Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe Glu 
65                  70                  75                  80  


Asp Lys Ala Lys Leu Thr Ala Val Ala Ser Ala Ser Thr Ala Tyr Met 
                85                  90                  95      


Glu Val Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
            100                 105                 110         


Arg Gly Leu Arg Arg Trp Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140 


<210>  11
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 VL

<400>  11

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Pro Cys Lys Ala Ser Gln Asp Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg Ala Asp 
            100                 105                 110 


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 VH

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ile Ser 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Lys Ile Leu Pro Gly Ser Gly Gly Ala Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Ser Thr Gly Thr Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125 


<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 VL

<400>  13

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Ala Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Tyr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp 
            100                 105                 110 


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 VH

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Val Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile His Pro Gly Ser Gly Val Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser His Gly Leu Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 VL

<400>  15

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 VH

<400>  16

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Gly Trp Val 
        35                  40                  45              


Ala Ser Leu Arg Thr Gly Gly Asn Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Arg His Trp Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 VL

<400>  17

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Gly Trp Tyr Gln Gln Glu Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 VH

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Ala Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Tyr Gly Asn Tyr Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 VL

<400>  19

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 HCDR3

<400>  20

Ala Arg Gly Gly Leu Tyr Tyr Asp Leu Asp Tyr 
1               5                   10      


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 HCDR2

<400>  21

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 HCDR1

<400>  22

Gly Phe Thr Phe Ser Ile Tyr Trp 
1               5               


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 LCDR3

<400>  23

Trp Gln Asp Arg His Phe Pro Arg Thr 
1               5                   


<210>  24
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 LCDR2

<400>  24

Leu Val Ser 
1           


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA105 LCDR1

<400>  25

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 HCDR3

<400>  26

Ala Arg Leu Gly Ile Gly Leu Arg Gly Ala Leu Asp Tyr 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 HCDR2

<400>  27

Ile Leu Pro Gly Ser Asn Thr 
1               5           


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 HCDR1

<400>  28

Gly Tyr Thr Phe Asn Ile Tyr Trp 
1               5               


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 LCDR3

<400>  29

Gln His Arg Tyr Gly Ser Pro Trp Thr 
1               5                   


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA39 LCDR2

<400>  30

Asn Ala Lys 
1           


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA38 LCDR1

<400>  31

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 HCDR3

<400>  32

Ala Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 HCDR2

<400>  33

Ile Thr Tyr Ser Gly Ser Thr 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 HCDR1

<400>  34

Gly Asp Ser Met Thr Asn Gly Tyr 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 LCDR3

<400>  35

Leu Gln Tyr Asp Glu Phe Pro Pro Thr 
1               5                   


<210>  36
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 LCDR2

<400>  36

Arg Ala Asn 
1           


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 LCDR1

<400>  37

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 HCDR3

<400>  38

Ala Arg Gly Gly Leu Tyr Tyr Asn Leu Asp Ser 
1               5                   10      


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 HCDR2

<400>  39

Ile Leu Pro Gly Ser Gly Asn Thr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 HCDR1

<400>  40

Gly Phe Thr Phe Ser Thr Tyr Trp 
1               5               


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 LCDR3

<400>  41

Trp Gln Asp Thr His Phe Pro Arg Thr 
1               5                   


<210>  42
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 LCDR2

<400>  42

Leu Val Ser 
1           


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA71 LCDR1

<400>  43

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 HCDR3

<400>  44

Ala Arg Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 HCDR2

<400>  45

Ile Leu Pro Gly Ser Gly Leu Thr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 HCDR1

<400>  46

Gly Phe Thr Phe Ser Thr Tyr Trp 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 LCDR3

<400>  47

Trp Gln Gly Ser His Phe Pro Gln Thr 
1               5                   


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 LCDR2

<400>  48

Leu Val Cys 
1           


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 LCDR1

<400>  49

Gln Ser Leu Leu Asp Ser Glu Gly Lys Thr Tyr 
1               5                   10      


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 HCDR3

<400>  50

Thr Arg Gly Leu Arg Arg Trp Gly Ala Met Asp Tyr 
1               5                   10          


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 HCDR2

<400>  51

Ile Leu Pro Gly Ser Gly Leu Thr 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 HCDR1

<400>  52

Gly Phe Thr Phe Ser Thr Tyr Trp 
1               5               


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 LCDR3

<400>  53

Gln Gln His Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  54
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 LCDR2

<400>  54

Ser Ala Ser 
1           


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB109 LCDR1

<400>  55

Gln Asp Val Ser Ser Ala 
1               5       


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 HCDR3

<400>  56

Ala Arg Leu Ser Thr Gly Thr Arg Gly Ala Phe Asp Tyr 
1               5                   10              


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 HCDR2

<400>  57

Ile Leu Pro Gly Ser Gly Gly Ala 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 HCDR1

<400>  58

Gly Tyr Thr Phe Ser Ile Ser Trp 
1               5               


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 LCDR3

<400>  59

Gln His His Tyr Gly Thr Pro Pro Thr 
1               5                   


<210>  60
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 LCDR2

<400>  60

Asn Ala Lys 
1           


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mB28 LCDR1

<400>  61

Glu Asn Val Tyr Ser Tyr 
1               5       


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 HCDR3

<400>  62

Ala Arg Asp Tyr Tyr Gly Ser Ser His Gly Leu Met Asp Tyr 
1               5                   10                  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 HCDR2

<400>  63

Ile His Pro Gly Ser Gly Val Thr 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 HCDR1

<400>  64

Gly Tyr Ala Phe Thr Asn Tyr Leu 
1               5               


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 LCDR3

<400>  65

Leu Gln Tyr Asp Glu Phe Pro Arg Thr 
1               5                   


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 LCDR2

<400>  66

Arg Ala Asn 
1           


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mC45 LCDR1

<400>  67

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 HCDR3

<400>  68

Ala Arg Gly Leu Arg His Trp Gly Tyr Phe Asp Val 
1               5                   10          


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 HCDR2

<400>  69

Leu Arg Thr Gly Gly Asn Thr 
1               5           


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 HCDR1

<400>  70

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 LCDR3

<400>  71

Gln Gln His Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 LCDR2

<400>  72

Ser Ala Ser 
1           


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE16 LCDR1

<400>  73

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 HCDR3

<400>  74

Met Tyr Gly Asn Tyr Pro Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 HCDR2

<400>  75

Ile Asp Pro Glu Asn Gly Asp Thr 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 HCDR1

<400>  76

Gly Phe Asn Ile Lys Asp Tyr Tyr 
1               5               


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 LCDR3

<400>  77

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  78
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 LCDR2

<400>  78

Tyr Thr Ser 
1           


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mE21 LCDR1

<400>  79

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 VH

<400>  80

Gln Gly Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ala Trp Leu Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Leu Pro Gly Ser Gly Leu Thr Asn Tyr Asn Glu Ile Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro 
        115                 120                 


<210>  81
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA75 VL

<400>  81

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Glu 
            20                  25                  30          


Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Arg Leu Ile Tyr Leu Val Cys Lys Leu Asp Cys Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Gly Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Ser 
                85                  90                  95      


His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp 
        


<210>  82
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC1a

<400>  82

Glu Met Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  83
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC1b

<400>  83

Glu Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  84
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC2a

<400>  84

Glu Met Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Glu Ser Met Thr Gln Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Gln Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Thr Thr Val Glu Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  85
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC2b

<400>  85

Glu Met Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Met Thr Gln Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  86
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC3

<400>  86

Gln Met Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  87
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC4

<400>  87

Gln Met Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Glu Ser Met Thr Gln Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Thr Ile Thr Arg Gln Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Thr Thr Val Glu Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  88
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC5a

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asn Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  89
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC5b

<400>  89

Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  90
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC5a

<400>  90

Gln Met Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Ala Val Ser Val Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC1a

<400>  91

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC1b

<400>  92

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Thr Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Met Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Ile Lys 
            100                 105         


<210>  93
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC2

<400>  93

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  94
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC3

<400>  94

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  95
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC4

<400>  95

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  96
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC5a

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  97
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC5b

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC5c

<400>  98

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  99
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH

<400>  99

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255 


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL

<400>  100

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  101
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vk1

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  102
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vlambda3


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Xaa Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Xaa Gln Ala Trp Asp Ser Ser Ala Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  103
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vh2

<400>  103

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Gly Phe Thr Gly Thr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  104
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vh4


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Xaa Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Xaa Ala 
                85                  90                  95      


Arg Gly Asp Ser Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain 3'- Primer

<400>  105
tatgcaaggc ttacaaccac a                                                 21


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain 3'- Primer

<400>  106
ctcattcctg ttgaagctct tgag                                              24


<210>  107
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-33-01_IGKJ4-01

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  108
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV4-59-02_IGHD6-13-01_IGHJ4-02

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Ser Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  109
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv1	LC1a x HC1a

<400>  109

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile 
                165                 170                 175     


Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  110
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv2	LC1b x HC1b

<400>  110

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Thr Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Met Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Ile Lys Glu Met Gln Leu Gln 
            100                 105                 110         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Lys Phe Pro Gly Lys Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile 
                165                 170                 175     


Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu Lys Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  111
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv3	LC2 x HC2a

<400>  111

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Thr Gly Glu Ser Met Thr Gln Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile 
                165                 170                 175     


Thr Arg Gln Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Glu Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  112
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv4	LC1a x HC2b

<400>  112

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Thr Gly Asp Ser Met Thr Gln Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile 
                165                 170                 175     


Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  113
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv5	LC2 x HC2b

<400>  113

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Thr Gly Asp Ser Met Thr Gln Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Lys Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile 
                165                 170                 175     


Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  114
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv6	LC3 x HC3

<400>  114

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Thr Ile 
                165                 170                 175     


Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  115
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv7	LC4 x HC4

<400>  115

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Ser Gly Glu Ser Met Thr Gln Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Thr Ile 
                165                 170                 175     


Thr Arg Gln Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Glu Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  116
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv8	LC5a x HC5a

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gln Val Gln Leu Gln 
            100                 105                 110         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile 
                165                 170                 175     


Ser Arg Asn Thr Ser Lys Asn Gln Tyr Ser Leu Lys Leu Ser Ser Val 
            180                 185                 190         


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  117
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv9	LC5b x HC5b

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gln Met Gln Leu Gln 
            100                 105                 110         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile 
                165                 170                 175     


Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu Lys Leu Ser Ser Val 
            180                 185                 190         


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  118
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv10	LC5c x HC5c

<400>  118

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gln Met Gln Leu Gln 
            100                 105                 110         


Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ala Ile Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Ser Pro Ser Arg Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile 
                165                 170                 175     


Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Ser Ser Val 
            180                 185                 190         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  119
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv11	LC2 x HC3

<400>  119

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Thr Ile 
                165                 170                 175     


Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  120
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv12	LC4 X HC3

<400>  120

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Thr Leu Lys 
            100                 105                 110         


Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Ser Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Phe Pro Gly Lys Ala Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly Arg Ile Thr Ile 
                165                 170                 175     


Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Thr Leu Ser Ser Val 
            180                 185                 190         


Thr Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  121
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv13	LC2 x HC5b

<400>  121

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Gln Leu Gln 
            100                 105                 110         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile 
                165                 170                 175     


Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu Lys Leu Ser Ser Val 
            180                 185                 190         


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  122
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A44-hv14	LC4 x HC5b

<400>  122

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Gln Arg Ser Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gln Met Gln Leu Gln 
            100                 105                 110         


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
        115                 120                 125             


Cys Thr Val Ser Gly Asp Ser Met Thr Asn Gly Tyr Trp Asn Trp Ile 
    130                 135                 140                 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Met Gly Tyr Ile Thr Tyr 
145                 150                 155                 160 


Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile 
                165                 170                 175     


Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu Lys Leu Ser Ser Val 
            180                 185                 190         


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp His Tyr Gly 
        195                 200                 205             


Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  123
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC1a

<400>  123
gagatgaccc tgaaagagtc cggccccacc ctggtcaaac ccacccagac cctgagcctg       60

acctgcagcg tgaccggcga cagcatgacc aacggctact ggaactggat ccggaagttc      120

cccggcaagg ccctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat cagcatcacc cggaacacca gcaagaacca gtactacctg      240

accctgtcca gcgtg                                                       255


<210>  124
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC1b

<400>  124
gagatgcagc tgcaggaaag cggccctggc ctggtcaaac ccagcgagac actgagcctg       60

acctgcagcg tgaccggcga cagcatgacc aacggctact ggaactggat ccggaagttc      120

cccggcaagg gcctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat cagcatcacc cggaacacca gcaagaacca gtactacctg      240

aagctgtcca gcgtg                                                       255


<210>  125
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC2a

<400>  125
gagatgaccc tgaaagagtc cggccccacc ctggtcaaac ccacccagac cctgagcctg       60

acctgcagcg tgaccggcga gagcatgacc cagggctact ggaactggat ccggaagttc      120

cccggcaagg ccctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat cagcatcacc cggcagacca gcaagaacca gtactacctg      240

accctgtcca gcgtg                                                       255


<210>  126
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC2b

<400>  126
gagatgaccc tgaaagagtc cggccccacc ctggtcaaac ccacccagac cctgagcctg       60

acctgcagcg tgaccggcga cagcatgacc cagggctact ggaactggat ccggaagttc      120

cccggcaagg ccctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat cagcatcacc cggaacacca gcaagaacca gtactacctg      240

accctgtcca gcgtg                                                       255


<210>  127
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC3

<400>  127
cagatgaccc tgaaagagtc cggccccacc ctggtcaaac ccacccagac cctgagcctg       60

acctgcagcg tgtccggcga cagcatgacc aacggctact ggaactggat ccggcagttc      120

cccggcaagg ccctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat caccatcacc cgggacacca gcaagaacca gtactacctg      240

accctgagca gcgtg                                                       255


<210>  128
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC4

<400>  128
cagatgaccc tgaaagagtc cggccccacc ctggtcaaac ccacccagac cctgagcctg       60

acctgcagcg tgtccggcga gagcatgacc cagggctact ggaactggat ccggcagttc      120

cccggcaagg ccctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agggccggat caccatcacc cggcagacca gcaagaacca gtactacctg      240

accctgagca gcgtg                                                       255


<210>  129
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC5a

<400>  129
caggtgcagc tgcaggaaag cggccctggc ctggtcaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcga cagcatgacc aacggctact ggaactggat ccggcagccc      120

cctggcaagg gcctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agtcccggat caccatcagc cggaacacca gcaagaacca gtacagcctg      240

aagctgagca gcgtg                                                       255


<210>  130
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC5b

<400>  130
cagatgcagc tgcaggaaag cggccctggc ctggtcaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcga cagcatgacc aacggctact ggaactggat ccggcagccc      120

cctggcaagg gcctcgagta catgggctac atcacctaca gcggcagcac ctactacaac      180

cccagcctga agtcccggat caccatcagc cgggacacca gcaagaacca gtacagcctg      240

aagctgagca gcgtg                                                       255


<210>  131
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC5c

<400>  131
cagatgcagc tgcagcagag cggccctggc ctggtcaaac ccagccagac cctgagcctg       60

acctgcgcca tcagcggcga cagcatgacc aacggctact ggaactggat ccggcagagc      120

cccagcagag gcctcgagta catgggctac atcacctaca gcggcagcac ctactacgcc      180

gtgtccgtga agtcccggat caccatcaac cgggacacca gcaagaacca gtacagcctg      240

cagctgagca gcgtg                                                       255


<210>  132
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC1a

<400>  132
gacatcaaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaagagcc ccaagaccct gatctaccgg gccaaccgca gcgtggacgg cgtgccaagc      180

agattttccg gcagcggcag cggccaggac tacagcctga ccatcagcag cctgcagccc      240

gaggacctgg gcatc                                                       255


<210>  133
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC1b

<400>  133
gacatcaaga tgacccagag ccccagcagc gtgtccgtgt ctcctggcca gaccgtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggccagtccc ccaagaccct gatctaccgg gccaaccgca gcgtggacgg cgtgccaagc      180

agattttccg gcagcggcag cggccaggac tacagcctga ccatcagcag cctgcaggcc      240

atggacgagg gcatc                                                       255


<210>  134
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC2

<400>  134
gacatcaaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaagagcc ccaagaccct gatctaccgg gcccagcgga gcgtggaagg cgtgccaagc      180

agattcagcg gcagcggctc cggccaggac tacagcctga ccatcagcag cctgcagccc      240

gaggacctgg gcatc                                                       255


<210>  135
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC3

<400>  135
gacatcaaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaagagcc ccaagaccct gatctaccgg gccaaccgca gcgtggacgg cgtgccaagc      180

agattttccg gcagcggcag cggccaggac tacagcctga ccatcagcag cctgcagccc      240

gaggacctgg ccacc                                                       255


<210>  136
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC4

<400>  136
gacatcaaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaagagcc ccaagaccct gatctaccgg gcccagcgga gcgtggaagg cgtgccaagc      180

agattcagcg gcagcggctc cggccaggac tacagcctga ccatcagcag cctgcagccc      240

gaggacctgg ccacc                                                       255


<210>  137
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC5a

<400>  137
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaaggccc ccaagctgct gatctaccgg gccaaccgca gcgtggacgg cgtgccaagc      180

agattttccg gcagcggctc cggcaccgac tacaccttca ccatcagcag cctgcagccc      240

gaggatatcg ccacc                                                       255


<210>  138
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC5b

<400>  138
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggcaaggccc ccaagaccct gatctaccgg gccaaccgca gcgtggacgg cgtgccaagc      180

agattttccg gcagcggcag cggccaggac tacaccttca ccatcagcag cctgcagccc      240

gaggatatcg ccacc                                                       255


<210>  139
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC5c

<400>  139
gagatcgtga tgacccagag ccccgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgca aggccagcca ggacatcaac agctacctga gctggctgca gcagaagccc      120

ggccaggccc ccagaaccct gatctaccgg gccaacagaa gcgtggacgg catccccgcc      180

agattcagcg gcagcggctc cggccaggac tacaccctga ccatcagcag cctggaaccc      240

gaggacttcg ccgtg                                                       255


<210>  140
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 VH

<400>  140

Glu Met Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Met Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp His Tyr Gly Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  141
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 VL

<400>  141

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  142
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mA44 VL

<400>  142

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe 
        115             


<210>  143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3-11-02_IGKJ4-0

<400>  143

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  144
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV6-1-02_IGHD6-13-01_IGHJ4-02

<400>  144

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Tyr Ser Ser Ser Trp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  145
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145

Arg Ala Gln 
1           


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Gly Glu Ser Met Thr Gln Gly Tyr 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
Gly Asp Ser Met Thr Gln Gly Tyr 
1               5               
