                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> COMPOSITIONS AND METHOD FOR TREATING COMPLEMENT-ASSOCIATED 
      CONDITIONS

<130> P5661R1-WO

<140>
<141>

<150> 62/021,487
<151> 2014-07-07

<150> 61/988,016
<151> 2014-05-02

<150> 61/988,012
<151> 2014-05-02

<150> 61/872,098
<151> 2013-08-30

<150> 61/866,651
<151> 2013-08-16

<150> 61/864,941
<151> 2013-08-12

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Gly Asn Thr Leu Arg Pro 
1               5           


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Leu Gln Ser Asp Ser Leu Pro Tyr Thr 
1               5                   


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Glu Gly Gly Val Asn Asn 
1               5       


<210> 7
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 9
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
attaccagca ctgatattga tgatgatatg aac                                    33


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ggaggcaata ctcttcgtcc t                                                 21


<210> 11
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
ttgcaaagtg attctttgcc gtacacg                                           27


<210> 12
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
ggatacacct tcactaacta tggaatgaac                                        30


<210> 13
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
tggattaaca cctacactgg agagacaaca tatgctgacg acttcaaggg a                51


<210> 14
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
gagggggggg ttaataac                                                     18


<210> 15
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220             


<210> 16
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (25)..(25)
<223> N6-tert-butyl-benzyl dA

<400> 17
gcctgctagc aacaaattca ctcaa                                             25


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (24)..(24)
<223> N6-tert-butyl-benzyl dA

<400> 18
cctgctagca acaaattcac tcaa                                              24


<210> 19
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (31)..(31)
<223> N6-tert-butyl-benzyl dA

<400> 19
cacatacgta tatcattttc aaactgcaga a                                      31


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (30)..(30)
<223> N6-tert-butyl-benzyl dA

<400> 20
gtatatcatt ttcaaactgc agaaaatcaa                                        30


<210> 21
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (31)..(31)
<223> /note="3'-Phosphate"

<400> 21
tcggaatgct aaatatttta tcccacttct t                                      31


<210> 22
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (30)..(30)
<223> /note="3'-Phosphate"

<400> 22
ttctcggaat gctaaatatt ttatcccact                                        30


<210> 23
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (31)..(31)
<223> /note="3'-Phosphate"

<400> 23
ctctgaatgc taaatatttt atcccacttc t                                      31


<210> 24
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (30)..(30)
<223> /note="3'-Phosphate"

<400> 24
ttctctgaat gctaaatatt ttatcccact                                        30


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (24)..(24)
<223> N6-tert-butyl-benzyl dA

<400> 25
tcggtgagag atggacactc aata                                              24


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (25)..(25)
<223> N6-tert-butyl-benzyl dA

<400> 26
cggtgagaga tggacactca ataca                                             25


<210> 27
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (27)..(27)
<223> N6-tert-butyl-benzyl dA

<400> 27
acatcgttga tatagtgaac ctcatca                                           27


<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (24)..(24)
<223> N6-tert-butyl-benzyl dA

<400> 28
tcgttgatat agtgaacctc atca                                              24


<210> 29
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> modified_base
<222> (4)..(4)
<223> 7-deaza dG

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="3'-Phosphate"

<400> 29
ctggggagtc aatccttggc ctctt                                             25


<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> modified_base
<222> (5)..(5)
<223> 7-deaza dG

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="3'-Phosphate"

<400> 30
ctggggagtc aatccttggc ctctt                                             25


<210> 31
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> modified_base
<222> (5)..(5)
<223> 7-deaza dG

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="3'-Phosphate"

<400> 31
ctggggagtc aatccttggc ctctt                                             25


<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="3'-Phosphate"

<400> 32
actggagagt caatccttgg cctct                                             25


<210> 33
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="3'-Phosphate"

<400> 33
actggagagt caatccttgg cctct                                             25


<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (24)..(24)
<223> N6-tert-butyl-benzyl dA

<400> 34
ggaagtgctt acacacccat ataa                                              24


<210> 35
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (27)..(27)
<223> N6-tert-butyl-benzyl dA

<400> 35
cctggaagtg cttacacacc catataa                                           27


<210> 36
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (25)..(25)
<223> N6-tert-butyl-benzyl dA

<400> 36
ccagtgatac atccaggtac attaa                                             25


<210> 37
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"


<220>
<221> modified_base
<222> (35)..(35)
<223> N6-tert-butyl-benzyl dA

<400> 37
atacatccag gtacattaat cactcttaga acaaa                                  35


<210> 38
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (30)..(30)
<223> /note="3'-Phosphate"

<400> 38
agagctttag aatacagtcc ctgaatgaaa                                        30


<210> 39
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-FAM"

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="3'-Phosphate"

<400> 39
ctttagaata cagtccctga atgaaagttg taaagg                                 36


<210> 40
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="3'-Phosphate"

<400> 40
agttttagaa tacagtccct gaatgaaagt tgtaa                                  35


<210> 41
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="5'-threoninol-HEX"

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="BHQ2 dye between nucleotides"

<220>
<221> misc_feature
<222> (39)..(39)
<223> /note="3'-Phosphate"

<400> 41
ttttagaata cagtccctga atgaaagttg taaaagtta                              39


