                         SEQUENCE LISTING

<110>  Glycosyn LLC
       Heidtman, Matthew
       Merighi, Massimo
       McCoy, John M.
 
<120>  STRAINS OF LACTOBACILLUS RHAMNOSUS GG CAPABLE OF GROWTH ON 
       LACTOSE AND THE USES THEREOF

<130>  37847-513001WO

<150>  61/862,603
<151>  2013-08-06

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  1
atgccgaaaa tcgatcagat ctttaacaat aacgtggcgt tggttgagct agacaaccat       60

agtcaagcgg ttgttaaggg acgggggatc gcgtttagaa gcgtggcgat gtgattccgg      120

ctaaacaaat tgaaaaaatt ttctaccttg caagtgaaac ttcccgccag aatctgtact      180

ttttacttcg caatattccg atcgacgtgg tgacgaccac ttatgaaatt attgacgttg      240

cgcaaaaaca atttcacctt aaggtacttg actatattta cattacgtta agcgatcata      300

tttacgaagc ctataaacgt tatcagaatg gaacgtatca agagacgatg gtgccggatt      360

ttcatattca gtatcctgca gagtatgccg tagctaacca agcgttgcag atcattgcag      420

ctaaccttgg cgtagcattt ccaccttccg aagtgaaaaa tcttgcctta cattttatca      480

atgccagcgg tgaagacgac aacgagcagg cctttgacaa gaataatgag gcgtcattaa      540

gtcaactggt gcaacgtgtt ttgaagcggc atcgcattac gagatcgcaa actaacggca      600

attattatga tcgcttcatg attcacttac agtatctgat tgaccgactg cagcgtgtta      660

atacggatgc tgttgccatt gtgcccgagg tggccaatga attagagcta aattatccgc      720

ggtcttatca gattgcttcg gaaatttttg atgagattaa ggatcagctt tatcgcaaca      780

tgagtgaaga cgaacgctta tactttatca ttcatattca acggctaatt aacgaagcgc      840

ctgcccacga tcaaaaacag ggcaaaaaat cataa                                 875


<210>  2
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  2

Met Pro Lys Ile Asp Gln Ile Phe Asn Asn Asn Val Ala Leu Val Glu 
1               5                   10                  15      


Leu Asp Asn His Ser Gln Ala Val Val Lys Gly Arg Gly Ile Ala Phe 
            20                  25                  30          


Arg Ser Val Ala Met 
        35          


<210>  3
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  3
atgcgtaaac aattacccaa ggactttgta atcggtggcg caactgctgc ttaccaagtt       60

gaaggggcaa ccaaagaaga cggaaaaggt cgagttcttt gggatgattt tctggaaaaa      120

caagggcggt ttagtcctga ccccgccgct gatttttatc atcgctatga tgaggatttg      180

gcgttagcag aagcatatgg tcatcaagta atacggcttt caattgcctg gtcgcgaatt      240

tttccggatg gtgccggggc ggtggaacct cgtggcgttg ctttctatca tcggctcttt      300

gctgcctgtg ccaagcatca tcttatcccg tttgtaacgt tgcatcattt tgatacacca      360

gaacggttac acgcgattgg tgactggctg agtcaagaaa tgctggaaga ttttgtcgag      420

tacgcgcggt tttgcttcga ggaatttccg gaaatcaaac actggattac gatcaatgaa      480

ccaacgtcca tggcagtgca acaatatacg agcggcactt ttcccccagc ggaaaccggt      540

cattttgata aaacatttca ggccgaacat aatcaaatcg ttgcccatgc gcgtattgtt      600

aatttgtaca agtcgatggg gctagatggt gaaatcggta tcgtgcatgc cttgcagaca      660

ccttatccat atagtgattc gtcggaagat tagcatgccg ctgatttaca ggatgcgttg      720

gaaaatcggc tgtatttaga tggcacactg gcaggagatt acgcccctaa gaccttggct      780

ttgatcaaag aaattctggc agcaaatcaa caaccgatgt ttaagcgtac cgacgaagag      840

atggcggcta ttaagaaggc ggcacaccag cttgattttg ttggagttaa caactacttc      900

agcaaatggc tgcgcgctta tcacggcaag tcggaaacga ttcataatgg tgatggctca      960

aagggatcgt cagttgcccg ccttcacggt atcggtgaag agaagaaacc ggccgggatt     1020

gagacaacgg attgggactg gtccatctat ccgcgtggta tgtatgacat gttgatgcgg     1080

attcatcgag attatccgtt agtaccagcc atctatgtca ccgaaaacgg tattggattg     1140

aaagaatcct taccagcaga agtgacgcca aatacggtca tcgcggatcc caaacgcatt     1200

gattatttga aaaaatattt aagtgccatt gcagatgcga ttcaggctgg cgcgaatgta     1260

aaaggctact ttgtctggtc actgcaggat cagttttcct ggacaaatgg ttatagcaaa     1320

cggtacggat tgtttttcgt cgactttccg acgcaaaaac gttatgtcaa gcaaagtgcc     1380

gaatggttaa aacaagttag ccaaacgcat gtgattcccg aataa                     1425


<210>  4
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  4

Met Arg Lys Gln Leu Pro Lys Asp Phe Val Ile Gly Gly Ala Thr Ala 
1               5                   10                  15      


Ala Tyr Gln Val Glu Gly Ala Thr Lys Glu Asp Gly Lys Gly Arg Val 
            20                  25                  30          


Leu Trp Asp Asp Phe Leu Glu Lys Gln Gly Arg Phe Ser Pro Asp Pro 
        35                  40                  45              


Ala Ala Asp Phe Tyr His Arg Tyr Asp Glu Asp Leu Ala Leu Ala Glu 
    50                  55                  60                  


Ala Tyr Gly His Gln Val Ile Arg Leu Ser Ile Ala Trp Ser Arg Ile 
65                  70                  75                  80  


Phe Pro Asp Gly Ala Gly Ala Val Glu Pro Arg Gly Val Ala Phe Tyr 
                85                  90                  95      


His Arg Leu Phe Ala Ala Cys Ala Lys His His Leu Ile Pro Phe Val 
            100                 105                 110         


Thr Leu His His Phe Asp Thr Pro Glu Arg Leu His Ala Ile Gly Asp 
        115                 120                 125             


Trp Leu Ser Gln Glu Met Leu Glu Asp Phe Val Glu Tyr Ala Arg Phe 
    130                 135                 140                 


Cys Phe Glu Glu Phe Pro Glu Ile Lys His Trp Ile Thr Ile Asn Glu 
145                 150                 155                 160 


Pro Thr Ser Met Ala Val Gln Gln Tyr Thr Ser Gly Thr Phe Pro Pro 
                165                 170                 175     


Ala Glu Thr Gly His Phe Asp Lys Thr Phe Gln Ala Glu His Asn Gln 
            180                 185                 190         


Ile Val Ala His Ala Arg Ile Val Asn Leu Tyr Lys Ser Met Gly Leu 
        195                 200                 205             


Asp Gly Glu Ile Gly Ile Val His Ala Leu Gln Thr Pro Tyr Pro Tyr 
    210                 215                 220                 


Ser Asp Ser Ser Glu Asp His Ala Ala Asp Leu Gln Asp Ala Leu Glu 
225                 230                 235                 240 


Asn Arg Leu Tyr Leu Asp Gly Thr Leu Ala Gly Asp Tyr Ala Pro Lys 
                245                 250                 255     


Thr Leu Ala Leu Ile Lys Glu Ile Leu Ala Ala Asn Gln Gln Pro Met 
            260                 265                 270         


Phe Lys Arg Thr Asp Glu Glu Met Ala Ala Ile Lys Lys Ala Ala His 
        275                 280                 285             


Gln Leu Asp Phe Val Gly Val Asn Asn Tyr Phe Ser Lys Trp Leu Arg 
    290                 295                 300                 


Ala Tyr His Gly Lys Ser Glu Thr Ile His Asn Gly Asp Gly Ser Lys 
305                 310                 315                 320 


Gly Ser Ser Val Ala Arg Leu His Gly Ile Gly Glu Glu Lys Lys Pro 
                325                 330                 335     


Ala Gly Ile Glu Thr Thr Asp Trp Asp Trp Ser Ile Tyr Pro Arg Gly 
            340                 345                 350         


Met Tyr Asp Met Leu Met Arg Ile His Arg Asp Tyr Pro Leu Val Pro 
        355                 360                 365             


Ala Ile Tyr Val Thr Glu Asn Gly Ile Gly Leu Lys Glu Ser Leu Pro 
    370                 375                 380                 


Ala Glu Val Thr Pro Asn Thr Val Ile Ala Asp Pro Lys Arg Ile Asp 
385                 390                 395                 400 


Tyr Leu Lys Lys Tyr Leu Ser Ala Ile Ala Asp Ala Ile Gln Ala Gly 
                405                 410                 415     


Ala Asn Val Lys Gly Tyr Phe Val Trp Ser Leu Gln Asp Gln Phe Ser 
            420                 425                 430         


Trp Thr Asn Gly Tyr Ser Lys Arg Tyr Gly Leu Phe Phe Val Asp Phe 
        435                 440                 445             


Pro Thr Gln Lys Arg Tyr Val Lys Gln Ser Ala Glu Trp Leu Lys Gln 
    450                 455                 460                 


Val Ser Gln Thr His Val Ile Pro 
465                 470         


<210>  5
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  5
atgcgtaaac aattacccaa ggactttgta atcggtggcg caactgctgc ttaccaagtt       60

gaaggggcaa ccaaagaaga cggaaaaggt cgagttcttt gggatgattt tctggaaaaa      120

caagggcggt ttagtcctga ccccgccgct gatttttatc atcgctatga tgaggatttg      180

gcgttagcag aagcatatgg tcatcaagta atacggcttt caattgcctg gtcgcgaatt      240

tttccggatg gtgccggggc ggtggaacct cgtggcgttg ctttctatca tcggctcttt      300

gctgcctgtg ccaagcatca tcttatcccg tttgtaacgt tgcatcattt tgatacacca      360

gaacggttac acgcgattgg tgactggctg agtcaagaaa tgctggaaga ttttgtcgag      420

tacgcgcggt tttgcttcga ggaatttccg gaaatcaaac actggattac gatcaatgaa      480

ccaacgtcca tggcagtgca acaatatacg agcggcactt ttcccccagc ggaaaccggt      540

cattttgata aaacatttca ggccgaacat aatcaaatcg ttgcccatgc gcgtattgtt      600

aatttgtaca agtcgatggg gctagatggt gaaatcggta tcgtgcatgc cttgcagaca      660

ccttatccat atagtgattc gtcggaagat aagcatgccg ctgatttaca ggatgcgttg      720

gaaaatcggc tgtatttaga tggcacactg gcaggagatt acgcccctaa gaccttggct      780

ttgatcaaag aaattctggc agcaaatcaa caaccgatgt ttaagcgtac cgacgaagag      840

atggcggcta ttaagaaggc ggcacaccag cttgattttg ttggagttaa caactacttc      900

agcaaatggc tgcgcgctta tcacggcaag tcggaaacga ttcataatgg tgatggctca      960

aagggatcgt cagttgcccg ccttcacggt atcggtgaag agaagaaacc ggccgggatt     1020

gagacaacgg attgggactg gtccatctat ccgcgtggta tgtatgacat gttgatgcgg     1080

attcatcgag attatccgtt agtaccagcc atctatgtca ccgaaaacgg tattggattg     1140

aaagaatcct taccagcaga agtgacgcca aatacggtca tcgcggatcc caaacgcatt     1200

gattatttga aaaaatattt aagtgccatt gcagatgcga ttcaggctgg cgcgaatgta     1260

aaaggctact ttgtctggtc actgcaggat cagttttcct ggacaaatgg ttatagcaaa     1320

cggtacggat tgtttttcgt cgactttccg acgcaaaaac gttatgtcaa gcaaagtgcc     1380

gaatggttaa aacaagttag ccaaacgcat gtgattcccg aataa                     1425


<210>  6
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  6

Met Arg Lys Gln Leu Pro Lys Asp Phe Val Ile Gly Gly Ala Thr Ala 
1               5                   10                  15      


Ala Tyr Gln Val Glu Gly Ala Thr Lys Glu Asp Gly Lys Gly Arg Val 
            20                  25                  30          


Leu Trp Asp Asp Phe Leu Glu Lys Gln Gly Arg Phe Ser Pro Asp Pro 
        35                  40                  45              


Ala Ala Asp Phe Tyr His Arg Tyr Asp Glu Asp Leu Ala Leu Ala Glu 
    50                  55                  60                  


Ala Tyr Gly His Gln Val Ile Arg Leu Ser Ile Ala Trp Ser Arg Ile 
65                  70                  75                  80  


Phe Pro Asp Gly Ala Gly Ala Val Glu Pro Arg Gly Val Ala Phe Tyr 
                85                  90                  95      


His Arg Leu Phe Ala Ala Cys Ala Lys His His Leu Ile Pro Phe Val 
            100                 105                 110         


Thr Leu His His Phe Asp Thr Pro Glu Arg Leu His Ala Ile Gly Asp 
        115                 120                 125             


Trp Leu Ser Gln Glu Met Leu Glu Asp Phe Val Glu Tyr Ala Arg Phe 
    130                 135                 140                 


Cys Phe Glu Glu Phe Pro Glu Ile Lys His Trp Ile Thr Ile Asn Glu 
145                 150                 155                 160 


Pro Thr Ser Met Ala Val Gln Gln Tyr Thr Ser Gly Thr Phe Pro Pro 
                165                 170                 175     


Ala Glu Thr Gly His Phe Asp Lys Thr Phe Gln Ala Glu His Asn Gln 
            180                 185                 190         


Ile Val Ala His Ala Arg Ile Val Asn Leu Tyr Lys Ser Met Gly Leu 
        195                 200                 205             


Asp Gly Glu Ile Gly Ile Val His Ala Leu Gln Thr Pro Tyr Pro Tyr 
    210                 215                 220                 


Ser Asp Ser Ser Glu Asp Lys His Ala Ala Asp Leu Gln Asp Ala Leu 
225                 230                 235                 240 


Glu Asn Arg Leu Tyr Leu Asp Gly Thr Leu Ala Gly Asp Tyr Ala Pro 
                245                 250                 255     


Lys Thr Leu Ala Leu Ile Lys Glu Ile Leu Ala Ala Asn Gln Gln Pro 
            260                 265                 270         


Met Phe Lys Arg Thr Asp Glu Glu Met Ala Ala Ile Lys Lys Ala Ala 
        275                 280                 285             


His Gln Leu Asp Phe Val Gly Val Asn Asn Tyr Phe Ser Lys Trp Leu 
    290                 295                 300                 


Arg Ala Tyr His Gly Lys Ser Glu Thr Ile His Asn Gly Asp Gly Ser 
305                 310                 315                 320 


Lys Gly Ser Ser Val Ala Arg Leu His Gly Ile Gly Glu Glu Lys Lys 
                325                 330                 335     


Pro Ala Gly Ile Glu Thr Thr Asp Trp Asp Trp Ser Ile Tyr Pro Arg 
            340                 345                 350         


Gly Met Tyr Asp Met Leu Met Arg Ile His Arg Asp Tyr Pro Leu Val 
        355                 360                 365             


Pro Ala Ile Tyr Val Thr Glu Asn Gly Ile Gly Leu Lys Glu Ser Leu 
    370                 375                 380                 


Pro Ala Glu Val Thr Pro Asn Thr Val Ile Ala Asp Pro Lys Arg Ile 
385                 390                 395                 400 


Asp Tyr Leu Lys Lys Tyr Leu Ser Ala Ile Ala Asp Ala Ile Gln Ala 
                405                 410                 415     


Gly Ala Asn Val Lys Gly Tyr Phe Val Trp Ser Leu Gln Asp Gln Phe 
            420                 425                 430         


Ser Trp Thr Asn Gly Tyr Ser Lys Arg Tyr Gly Leu Phe Phe Val Asp 
        435                 440                 445             


Phe Pro Thr Gln Lys Arg Tyr Val Lys Gln Ser Ala Glu Trp Leu Lys 
    450                 455                 460                 


Gln Val Ser Gln Thr His Val Ile Pro Glu 
465                 470                 


<210>  7
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  7
atgcgtaaac aattacccaa ggactttgta atcggtggcg caactgctgc ttaccaagtt       60

gaaggggcaa ccaaagaaga cggaaaaggt cgagttcttt gggatgattt tctggaaaaa      120

caagggcggt ttagtcctga ccccgccgct gatttttatc atcgctatga tgaggatttg      180

gcgttagcag aagcatatgg tcatcaagta atacggcttt caattgcctg gtcgcgaatt      240

tttccggatg gtgccggggc ggtggaacct cgtggcgttg ctttctatca tcggctcttt      300

gctgcctgtg ccaagcatca tcttatcccg tttgtaacgt tgcatcattt tgatacacca      360

gaacggttac acgcgattgg tgactggctg agtcaagaaa tgctggaaga ttttgtcgag      420

tacgcgcggt tttgcttcga ggaatttccg gaaatcaaac actggattac gatcaatgaa      480

ccaacgtcca tggcagtgca acaatatacg agcggcactt ttcccccagc ggaaaccggt      540

cattttgata aaacatttca ggccgaacat aatcaaatcg ttgcccatgc gcgtattgtt      600

aatttgtaca agtcgatggg gctagatggt gaaatcggta tcgtgcatgc cttgcagaca      660

ccttatccat atagtgattc gtcggaagat cagcatgccg ctgatttaca ggatgcgttg      720

gaaaatcggc tgtatttaga tggcacactg gcaggagatt acgcccctaa gaccttggct      780

ttgatcaaag aaattctggc agcaaatcaa caaccgatgt ttaagcgtac cgacgaagag      840

atggcggcta ttaagaaggc ggcacaccag cttgattttg ttggagttaa caactacttc      900

agcaaatggc tgcgcgctta tcacggcaag tcggaaacga ttcataatgg tgatggctca      960

aagggatcgt cagttgcccg ccttcacggt atcggtgaag agaagaaacc ggccgggatt     1020

gagacaacgg attgggactg gtccatctat ccgcgtggta tgtatgacat gttgatgcgg     1080

attcatcgag attatccgtt agtaccagcc atctatgtca ccgaaaacgg tattggattg     1140

aaagaatcct taccagcaga agtgacgcca aatacggtca tcgcggatcc caaacgcatt     1200

gattatttga aaaaatattt aagtgccatt gcagatgcga ttcaggctgg cgcgaatgta     1260

aaaggctact ttgtctggtc actgcaggat cagttttcct ggacaaatgg ttatagcaaa     1320

cggtacggat tgtttttcgt cgactttccg acgcaaaaac gttatgtcaa gcaaagtgcc     1380

gaatggttaa aacaagttag ccaaacgcat gtgattcccg aataa                     1425


<210>  8
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  8

Met Arg Lys Gln Leu Pro Lys Asp Phe Val Ile Gly Gly Ala Thr Ala 
1               5                   10                  15      


Ala Tyr Gln Val Glu Gly Ala Thr Lys Glu Asp Gly Lys Gly Arg Val 
            20                  25                  30          


Leu Trp Asp Asp Phe Leu Glu Lys Gln Gly Arg Phe Ser Pro Asp Pro 
        35                  40                  45              


Ala Ala Asp Phe Tyr His Arg Tyr Asp Glu Asp Leu Ala Leu Ala Glu 
    50                  55                  60                  


Ala Tyr Gly His Gln Val Ile Arg Leu Ser Ile Ala Trp Ser Arg Ile 
65                  70                  75                  80  


Phe Pro Asp Gly Ala Gly Ala Val Glu Pro Arg Gly Val Ala Phe Tyr 
                85                  90                  95      


His Arg Leu Phe Ala Ala Cys Ala Lys His His Leu Ile Pro Phe Val 
            100                 105                 110         


Thr Leu His His Phe Asp Thr Pro Glu Arg Leu His Ala Ile Gly Asp 
        115                 120                 125             


Trp Leu Ser Gln Glu Met Leu Glu Asp Phe Val Glu Tyr Ala Arg Phe 
    130                 135                 140                 


Cys Phe Glu Glu Phe Pro Glu Ile Lys His Trp Ile Thr Ile Asn Glu 
145                 150                 155                 160 


Pro Thr Ser Met Ala Val Gln Gln Tyr Thr Ser Gly Thr Phe Pro Pro 
                165                 170                 175     


Ala Glu Thr Gly His Phe Asp Lys Thr Phe Gln Ala Glu His Asn Gln 
            180                 185                 190         


Ile Val Ala His Ala Arg Ile Val Asn Leu Tyr Lys Ser Met Gly Leu 
        195                 200                 205             


Asp Gly Glu Ile Gly Ile Val His Ala Leu Gln Thr Pro Tyr Pro Tyr 
    210                 215                 220                 


Ser Asp Ser Ser Glu Asp Gln His Ala Ala Asp Leu Gln Asp Ala Leu 
225                 230                 235                 240 


Glu Asn Arg Leu Tyr Leu Asp Gly Thr Leu Ala Gly Asp Tyr Ala Pro 
                245                 250                 255     


Lys Thr Leu Ala Leu Ile Lys Glu Ile Leu Ala Ala Asn Gln Gln Pro 
            260                 265                 270         


Met Phe Lys Arg Thr Asp Glu Glu Met Ala Ala Ile Lys Lys Ala Ala 
        275                 280                 285             


His Gln Leu Asp Phe Val Gly Val Asn Asn Tyr Phe Ser Lys Trp Leu 
    290                 295                 300                 


Arg Ala Tyr His Gly Lys Ser Glu Thr Ile His Asn Gly Asp Gly Ser 
305                 310                 315                 320 


Lys Gly Ser Ser Val Ala Arg Leu His Gly Ile Gly Glu Glu Lys Lys 
                325                 330                 335     


Pro Ala Gly Ile Glu Thr Thr Asp Trp Asp Trp Ser Ile Tyr Pro Arg 
            340                 345                 350         


Gly Met Tyr Asp Met Leu Met Arg Ile His Arg Asp Tyr Pro Leu Val 
        355                 360                 365             


Pro Ala Ile Tyr Val Thr Glu Asn Gly Ile Gly Leu Lys Glu Ser Leu 
    370                 375                 380                 


Pro Ala Glu Val Thr Pro Asn Thr Val Ile Ala Asp Pro Lys Arg Ile 
385                 390                 395                 400 


Asp Tyr Leu Lys Lys Tyr Leu Ser Ala Ile Ala Asp Ala Ile Gln Ala 
                405                 410                 415     


Gly Ala Asn Val Lys Gly Tyr Phe Val Trp Ser Leu Gln Asp Gln Phe 
            420                 425                 430         


Ser Trp Thr Asn Gly Tyr Ser Lys Arg Tyr Gly Leu Phe Phe Val Asp 
        435                 440                 445             


Phe Pro Thr Gln Lys Arg Tyr Val Lys Gln Ser Ala Glu Trp Leu Lys 
    450                 455                 460                 


Gln Val Ser Gln Thr His Val Ile Pro Glu 
465                 470                 


<210>  9
<211>  8936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  9
ggatccacag gacgggtgtg gtcgccatga tcgcgtagtc gatagtggct ccaagtagcg       60

aagcgagcag gactgggcgg cggccaaagc ggtcggacag tgctccgaga acgggtgcgc      120

atagaaattg catcaacgca tatagcgcta gcagcacgcc atagtgactg gcgatgctgt      180

cggaatggac gatatcccgc aagaggcccg gcagtaccgg cataaccaag cctatgccta      240

cagcatccag ggtgacggtg ccgaggatga cgatgagcgc attgttagat ttcatacacg      300

gtgcctgact gcgttagcaa tttaactgtg ataaactacc gcattaaagc ttatcgatga      360

taagctgtca aacatgagaa ttacaactta tatcgtatgg ggctgacttc aggtgctaca      420

tttgaagaga taaattgcac tgaaatctag aaatatttta tctgattaat aagatgatct      480

tcttgagatc gttttggtct gcgcgtaatc tcttgctctg aaaacgaaaa aaccgccttg      540

cagggcggtt tttcgaaggt tctctgagct accaactctt tgaaccgagg taactggctt      600

ggaggagcgc agtcaccaaa acttgtcctt tcagtttagc cttaaccggc gcatgacttc      660

aagactaact cctctaaatc aattaccagt ggctgctgcc agtggtgctt ttgcatgtct      720

ttccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg actgaacggg      780

gggttcgtgc atacagtcca gcttggagcg aactgcctac ccggaactga gtgtcaggcg      840

tggaatgaga caaacgcggc cataacagcg gaatgacacc ggtaaaccga aaggcaggaa      900

caggagagcg cacgagggag ccgccagggg gaaacgcctg gtatctttat agtcctgtcg      960

ggtttcgcca ccactgattt gagcgtcaga tttcgtgatg cttgtcaggg gggcggagcc     1020

tatggaaaaa cggctttgcc gcggccctct cacttccctg ttaagtatct tcctggcatc     1080

ttccaggaaa tctccgcccc gttcgtaagc catttccgct cgccgcagtc gaacgaccga     1140

gcgtagcgag tcagtgagcg aggaagcgga atatatcctg tatcacatat tctgctgacg     1200

caccggtgca gccttttttc tcctgccaca tgaagcactt cactgacacc ctcatcagtg     1260

ccaacatagt aagccagtat acactccgct agcgctgatg tccggcggtg cttttgccgt     1320

tacgcaccac cccgtcagta gctgaacagg agggacagct gatagaaaca gaagccactg     1380

gagcacctca aaaacaccat catacactaa atcagtaagt tggcagcatc acccgacgca     1440

ctttgcgccg aataaatacc tgtgacggaa gatcacttcg cagaataaat aaatcctggt     1500

gtccctgttg ataccgggaa gccctgggcc aacttttggc gaaaatgaga cgttgatcgg     1560

cacgtaagag gttccaactt tcaccataat gaaataagat cactaccggg cgtatttttt     1620

gagttatcga gattttcagg agctaaggaa gctaaaatgg agaaaaaaat cactggatat     1680

accaccgttg atatatccca atggcatcgt aaagaacatt ttgaggcatt tcagtcagtt     1740

gctcaatgta cctataacca gaccgttcag ctggatatta cggccttttt aaagaccgta     1800

aagaaaaata agcacaagtt ttatccggcc tttattcaca ttcttgcccg cctgatgaat     1860

gctcatccgg aattctattt aatcactttg actagcaaat actaacaaca agacacacac     1920

accaaaaatc aaaaattcac tacttttagt taaaaaccac gtaaccacaa gaactaatcc     1980

aatccatgta atcgggttct tcaaatattt ctccaagatt ttcctcctct aatatgctca     2040

acttaaatga cctattcaat aaatctatta tgctgctaaa tagtttatag gacaaataag     2100

tatactctaa tgacctataa aagatagaaa attaaaaaat caagtgttcg cttcgctctc     2160

actgcccctc gacgttttag tagcctttcc ctcacttcgt tcagtccaag ccaactaaaa     2220

gttttcgggc tactctctcc ttctccccct aataattaat taaaatctta ctctgtatat     2280

ttctgctaat cattcgctaa acagcaaaga aaaaacaaac acgtatcata gatataaatg     2340

taatggcata gtgcgggttt tattttcagc ctgtatcata gctaaacaaa tcgagttgtg     2400

tgtccgtttt agggcgttct gctagcttgt ttaaagtctc ttgaatgaat gtatgctcta     2460

agtcaaaaga atttgtcagc gcctttatat agctttcttt ttcttctttt tttactttaa     2520

tgatcgatag caacaatgat ttaacactag caagttgaat gccaccattt cttcctggtt     2580

taatcttaaa gaaaatttcc tgattcgcct tcagtacctt cagcaattta tctaatgtcc     2640

gttcaggaat gcctagcact tctctaatct cttttttggt cgtcactaaa taaggcttgt     2700

atacatcgct tttttcgcta atataagcca ttaaatcttc tttccattct gacaaatgaa     2760

cacgttgacg ttcgcttctt tttttcttga atttaaacca cccttgacgg acaaataaat     2820

ctttactggt taaatcactt gatacccaag ctttgcaaag aatggtaatg tattccctat     2880

tagccccttg atagttttct gaataggcac ttctaacaat tttgattact tctttttctt     2940

ctaagggttg atctaatcga ttattaaact caaacatatt atattcgcac gtttcgattg     3000

aatagcctga actaaagtag gctaaagaga gggtaaacat gacgttatta cgccctatta     3060

aacccttttc tcctgaaaat ttcgtttcgt gcaataagag attaaaccag ggttcatcta     3120

cttgtttttt gccttctgta ccgcttaaaa ccgttagact tgaacgagta aagcccttat     3180

tatctgtttg tttgaaagac caatcttgcc attctttgaa agaataacgg taattaggat     3240

caaaaaattc tacattgtcc gttcttggta tgcgagcaat accaaaatga ttacacgtta     3300

gatcaactgg caaagacttt ccaaaatatt ctcggatatt ttgcgaaatt attttggctg     3360

ctttgacaga tttaaattct gattttgaag tcacatagac tggcgtttct aaaacaaaat     3420

atgcttgata acctttatca gatttgataa tcatagtagg cataaaacct aaatcaatag     3480

cggttgttaa aatatcgctt gctgaaatag tttcttttgc cgtgtgaata tcaaaatcaa     3540

taaagaaggt attgatttgt cttaaattgt tttcagaatg tcctttcgtg tatgaacggt     3600

tttcgtctgc atacgttcca taacgataaa cgttgggtgt ccaatgtgta aatgtatctt     3660

gattttcttg aatcgcttcc tcggaagtca gaacaacacc acgaccgcca atcatgcttg     3720

attttgagcg atacgcaaaa atagcccctt tgcttttacc tggcttggta gtgattgagc     3780

gaattttact atttttaaat ttgtacttta acaagccgtc atgaagcaca gtttctacaa     3840

caaaagggat attcattcag ctgttctcct ttcctataaa tcctataaaa taggttgttt     3900

aattaacttg gtttgctttt tcattcaact gtttcaatat tgcatgtttt gaaaaagatt     3960

tttttccttt ataagtcaat ttttttccac taatcgaata aattattttg ttattttcta     4020

ttaacttata tatataatct tccccctccg aagaaaaata cttatctgat tttgtttcta     4080

agtagatatt tctcttttct aactctttct taaacgtttc tagtgtatag atatttgcta     4140

attttcttat ctccaataaa ctatttttta tataagtttt acattcatca tgattcatac     4200

aaactccacc ttctataaat gaatacaaaa aaagcaatca aacgatttcc gattgattgc     4260

ttaacaattc ttaaattcag tagcttagat acttgaaaac tctctgattt ccctatataa     4320

tgatagtacg gttatatacc gtcttcaaac aaagttaatt aaataacttc ttacgaggga     4380

agagttcatc tgactaactg ataagcgttg gtttggcaat cttatcgggc tatgcattta     4440

taaaatgtcg tcaaacattt tataaatgtg tcatggctct tttttcgttt ctattcagtt     4500

cgttgtttcg ttatatctag tataccgctt ttaaaaaaaa ataagcaacg atttcgtgca     4560

ttattcacac gaagtcattg cttttttctt cttccatttc taaatccaat gttacttgtt     4620

ctgattctgt ttctggctct ggttctgttg gctcatttgg gattaaatcc actactagcg     4680

ttgagttagt taactttgca atttgttcta gtgtttttat ggttggatct gattttcctg     4740

attctattcg tgaataattt gatctactca tttctaattc ttggggtacc gccagcattt     4800

cggaaaaaaa ccacgctaag gattttttct ataaaaagag ccgttatatt aagaataaaa     4860

cggctctttt atacgtaaag gacgtaaatt catttgccca gtgtcatgta atccttcaaa     4920

tttgtattct ccaagaaaat tgatatgttc ccatcctaac ggccacgcat atggcattaa     4980

atcttctcta aattctcctc ttgcttttaa ttcttctacg gctttttcca tatatacagt     5040

gttccacaca cttatagcgt taataattat gtttagtgca ctagctcttt gtaactggtc     5100

ttggagagca cgttctctaa attctccacg ttgtccaaaa aatatagttc tagctaatgc     5160

attgattgct tctcctttat ttaaaccttt ttgaacccgt ctccttacgg ctttattaga     5220

tatgtaatcc agcgtaaaga gggttttctc gattcgtccc atttctccaa gtgctgttgc     5280

gagtttattt tgtcttgcat atgatccgag cttccccatg ataagagcgc tagggacctc     5340

tttagctcct tggaagctgt cagtagtata cctaataatt tatctacatt ccctttagta     5400

acgtgtaact ttccaaattt acaaaagcga ctcatagaat tatttcctcc cgttaaataa     5460

tagataacta ttaaaaatag acaatacttg ctcataagta acggtactta aattgtttac     5520

tttggcgtgt ttcattgctt gatgaaactg atttttagta aacagttgac gatattctcg     5580

attgacccat tttgaaacaa agtacgtata tagcttccaa tatttatctg gaacatctgt     5640

ggtatggcgg gtaagtttta ttaagacact gtttactttt ggtttaggat gaaagcattc     5700

cgctggcagc ttaagcaatt gctgaatcga gacttgagtg tgcaagagca accctagtgt     5760

tcggtgaata tccaaggtac gcttgtagaa tccttcttca acaatcagat agatgtcaga     5820

cgcatggctt tcaaaaacca cttttttaat aatttgtgtg cttaaatggt aaggaatact     5880

cccaacaatt ttatacctct gtttgttagg gaattgaaac tgtagaatat cttggtgaat     5940

taaagtgaca cgagtattca gttttaattt ttctgacgat aagttgaata gatgactgtc     6000

taattcaata gacgttacct gtttacttat tttagccagt ttcgtcgtta aatgcccttt     6060

acctgttcca atttcgtaaa cggtatcggt ttcttttaaa ttcaattgtt ttattatttg     6120

gttgagtact ttttcactcg ttaaaaagtt ttgagaatat tttatatttt tgttcatgta     6180

atcactcctt cttaattaca aatttttagc atctaattta acttcaattc ctattataca     6240

aaattttaag atactgcact atcaacacac tcttaagttt gcttctaagt cttatttcca     6300

taacttcttt tacgtttccg ccattctttg ctgtttcgat ttttatgata tggtgcaagt     6360

cagcacgaac acgaaccgtc ttatctccca ttatatcttt ttttgcactg attggtgtat     6420

catttcgttt ttctttttgt gcgcttcttg ataaaaggga tagtaattca ttcctggttg     6480

caaattttga aaaccgctac ggatcacatc tttttctaaa ctattgatcc atagtctttt     6540

atacgtttta tctttagaaa aggcatttgc tttatgaatg atcgaccagg caatgttttc     6600

gccttctctg tcgctatctg ttgcgacaat gattgtattt gcttgtttta aaagttcagc     6660

aacaatttta aactgctttt ttttatctgt tgccacttca aaatcgtatc gattctagac     6720

tcgagatgcg ccgcgtgcgg ctgctggaga tggcggacgc gatggatatg ttctgccaag     6780

ggttggtttg cgcattcaca gttctccgca agaattgatt ggctccaatt cttggagtgg     6840

tgaatccgtt agcgaggtgc cgccggcttc cattcaggtc gaggtggccc ggctccatgc     6900

accgcgacgc aacgcgggga ggcagacaag gtatagggcg gcgcctacaa tccatgccaa     6960

cccgttccat gtgctcgccg aggcggcata aatcgccgtg acgatcagcg gtccagtgat     7020

cgaagttagg ctggtaagag ccgcgagcga tccttgaagc tgtccctgat ggtcgtcatc     7080

tacctgcctg gacagcatgg cctgcaacgc gggcatcccg atgccgccgg aagcgagaag     7140

aatcataatg gggaaggcca tccagcctcg cgtcgcgaac gccagcaaga cgtagcccag     7200

cgcgtcggcc gccatgccgg cgataatggc ctgcttctcg ccgaaacgtt tggtggcggg     7260

accagtgacg aaggcttgag cgagggcgtg caagattccg aataccgcaa gcgacaggcc     7320

gatcatcgtc gcgctccagc gaaagcggtc ctcgccgaaa atgacccaga gcgctgccgg     7380

cacctgtcct acgagttgca tgataaagaa gacagtcata agtgcggcga cgatagtcat     7440

gccccgcgcc caccggaagg agctgactgg gttgaaggct ctcaagggca tcggtcgaca     7500

gtctagaatc gatacgattt tgaagtggca acagataaaa aaaagcagtt taaaattgtt     7560

gctgaacttt taaaacaagc aaatacaatc attgtcgcaa cagatagcga cagagaaggc     7620

gaaaacattg cctggtcgat cattcataaa gcaaatgcct tttctaaaga taaaacgtat     7680

aaaagactat ggatcaatag tttagaaaaa gatgtgatcc gtagcggttt tcaaaatttg     7740

caaccaggaa tgaattacta tcccttttat caagaagcgc acaaaaagaa aaacgaaatg     7800

atacaccaat cagtgcaaaa aaagatataa tgggagataa gacggttcgt gttcgtgctg     7860

acttgcacca tatcataaaa atcgaaacag caaagaatgg cggaaacgta aaagaagtta     7920

tggaaataag acttagaagc aaacttaaga gtgtgttgat agtgcagtat cttaaaattt     7980

tgtataatag gaattgaagt taaattagat gctaaaaatt tgtaattagc ggccgcagaa     8040

ggagtgaatt catgccgaaa atcgatcaga tctttaacaa taacgtggcg ttggttgagc     8100

tagacaacca tagtcaagcg gttgttaagg gacgggggat cgcgtttcaa aagaagcgtg     8160

gcgatgtgat tccggctaaa caaattgaaa aaattttcta ccttgcaagt gaaacttccc     8220

gccagaatct gtacttttta cttcgcaata ttccgatcga cgtggtgacg accacttatg     8280

aaattattga cgttgcgcaa aaacaatttc accttaaggt acttgactat atttacatta     8340

cgttaagcga tcatatttac gaagcctata aacgttatca gaatggaacg tatcaagaga     8400

cgatggtgcc ggattttcat attcagtatc ctgcagagta tgccgtagct aaccaagcgt     8460

tgcagatcat tgcagctaac cttggcgtag catttccacc ttccgaagtg aaaaatcttg     8520

ccttacattt tatcaatgcc agcggtgaag acgacaacga gcaggccttt gacaagaata     8580

atgaggcgtc attaagtcaa ctggtgcaac gtgttttgaa gcggcatcgc attacgagat     8640

cgcaaactaa cggcaattat tatgatcgct tcatgattca cttacagtat ctgattgacc     8700

gactgcagcg tgttaatacg gatgctgttg ccattgtgcc cgaggtggcc aatgaattag     8760

agctaaatta tccgcggtct tatcagattg cttcggaaat ttttgatgag attaaggatc     8820

agctttatcg caacatgagt gaagacgaac gcttatactt tatcattcat attcaacggc     8880

taattaacga agcgcctgcc cacgatcaaa aacagggcaa aaaatcataa actagt         8936


<210>  10
<211>  870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  10
atgttgctaa aggtcaagca agtctataac aataatgctg tacttgtaga cgttggcaac       60

ggtaaagagg cgattcttca ggggaaagga attggtttca gcaagcgtaa aggtgatgac      120

gttgatccaa aagcgagttc ggaaatactt tatctaaatg atacgcaagt caaaaatcac      180

tttacatctt tactcaaaga tgtaccgatt gacattgttg ttgctacatt tggtgtgatc      240

ggaatggcaa aaaagaagta tcactatccg gttttgaact atatttatgt cacacttacg      300

gaccacgtct ttcagatgta taaacgattg actgccggca aatatcaagc tagtccagcg      360

cctgacatcc gtgatcgtta cccgttgcct taccagatcg cagccgatgc gcgccgacag      420

cttaaccatg atcttggcgt tcagtttcct gaagccgaaa ttaagaatat tgccttacat      480

tttattaatg caaagggagt ggatggcgaa ctggatccga ccgtgaccct gacggcgcgc      540

gtcaatgcaa tcgtgacaca agtatttgct aaatatgggt taaatcgcaa ttttgctaat      600

caaaattact tcgatcggct aatgattcat ttgcaatacc ttgttgaacg tttaaatacc      660

aatgagcaag acgaggctga ccttggtccg gaaattggtc aggacttcag gcgcctttat      720

cccaaatcgt ttacgatcgc aactgaaatt tgtacggagc tggaaaaagc cttacaaatt      780

aagctcaacg aaaacgagca tgtgtacttt attatccata ttcaacggct catccaagaa      840

ccgcaaacac ttccgcctga atatccatag                                       870


<210>  11
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  11

Met Leu Leu Lys Val Lys Gln Val Tyr Asn Asn Asn Ala Val Leu Val 
1               5                   10                  15      


Asp Val Gly Asn Gly Lys Glu Ala Ile Leu Gln Gly Lys Gly Ile Gly 
            20                  25                  30          


Phe Ser Lys Arg Lys Gly Asp Asp Val Asp Pro Lys Ala Ser Ser Glu 
        35                  40                  45              


Ile Leu Tyr Leu Asn Asp Thr Gln Val Lys Asn His Phe Thr Ser Leu 
    50                  55                  60                  


Leu Lys Asp Val Pro Ile Asp Ile Val Val Ala Thr Phe Gly Val Ile 
65                  70                  75                  80  


Gly Met Ala Lys Lys Lys Tyr His Tyr Pro Val Leu Asn Tyr Ile Tyr 
                85                  90                  95      


Val Thr Leu Thr Asp His Val Phe Gln Met Tyr Lys Arg Leu Thr Ala 
            100                 105                 110         


Gly Lys Tyr Gln Ala Ser Pro Ala Pro Asp Ile Arg Asp Arg Tyr Pro 
        115                 120                 125             


Leu Pro Tyr Gln Ile Ala Ala Asp Ala Arg Arg Gln Leu Asn His Asp 
    130                 135                 140                 


Leu Gly Val Gln Phe Pro Glu Ala Glu Ile Lys Asn Ile Ala Leu His 
145                 150                 155                 160 


Phe Ile Asn Ala Lys Gly Val Asp Gly Glu Leu Asp Pro Thr Val Thr 
                165                 170                 175     


Leu Thr Ala Arg Val Asn Ala Ile Val Thr Gln Val Phe Ala Lys Tyr 
            180                 185                 190         


Gly Leu Asn Arg Asn Phe Ala Asn Gln Asn Tyr Phe Asp Arg Leu Met 
        195                 200                 205             


Ile His Leu Gln Tyr Leu Val Glu Arg Leu Asn Thr Asn Glu Gln Asp 
    210                 215                 220                 


Glu Ala Asp Leu Gly Pro Glu Ile Gly Gln Asp Phe Arg Arg Leu Tyr 
225                 230                 235                 240 


Pro Lys Ser Phe Thr Ile Ala Thr Glu Ile Cys Thr Glu Leu Glu Lys 
                245                 250                 255     


Ala Leu Gln Ile Lys Leu Asn Glu Asn Glu His Val Tyr Phe Ile Ile 
            260                 265                 270         


His Ile Gln Arg Leu Ile Gln Glu Pro Gln Thr Leu Pro Pro Glu Tyr 
        275                 280                 285             


Pro 
    


<210>  12
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  12
ccacaaatca tgacgctgag agtagcgcgt gatttgtt                               38


<210>  13
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  13
ccacaaatca tgacgctgag agtagcgcgt gatttgtt                               38


<210>  14
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  14
ccacaaatca tgacgctgag agtagcgcgt gatttgta                               38


<210>  15
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  altered sequence

<400>  15
ccacaaatca tgacgctgag agtagcgcgt gatttgtt                               38


