                         SEQUENCE LISTING

<110>  MCKNIGHT, Susan Faas
       COFIELL, Roxanne
       KUKREJA, Anjli
       BEDARD, Krystin A.
       YAN, Yan
 
<120>  ATYPICAL HEMOLYTIC UREMIC SYNDROME BIOMARKER PROTEINS

<130>  AXJ-176PC

<140>  New Application
<141>  Concurrently Herewith

<150>  US 61/913,180
<151>  2013-12-06

<150>  US 61/863,299
<151>  2013-08-07

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(244)
<223>  Human Factor B fragment Ba

<400>  1

Leu Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala 
1               5                   10                  15      


Arg Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly 
            20                  25                  30          


Ser Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro 
        35                  40                  45              


Ser Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr 
    50                  55                  60                  


Gly Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys 
65                  70                  75                  80  


Ala Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn 
                85                  90                  95      


Gly Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile 
            100                 105                 110         


Ser Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg 
        115                 120                 125             


Thr Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp 
    130                 135                 140                 


Asn Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg 
145                 150                 155                 160 


Lys Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys 
                165                 170                 175     


Ser Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu 
            180                 185                 190         


Gly Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met 
        195                 200                 205             


Tyr Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr 
    210                 215                 220                 


Glu Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu 
225                 230                 235                 240 


Gln Gln Lys Arg 
                


<210>  2
<211>  77
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(77)
<223>  Human Complement Component C3a

<400>  2

Ser Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro 
1               5                   10                  15      


Lys Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met 
            20                  25                  30          


Arg Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala 
        35                  40                  45              


Cys Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 
    50                  55                  60                  


Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 
65                  70                  75          


<210>  3
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(74)
<223>  Human Complement Component C5a

<400>  3

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg 
65                  70                  


<210>  4
<211>  155
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(155)
<223>  Human Prothrombin Activation Fragment 1

<400>  4

Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu 
1               5                   10                  15      


Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu 
            20                  25                  30          


Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu 
        35                  40                  45              


Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn 
    50                  55                  60                  


Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr 
65                  70                  75                  80  


Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys 
                85                  90                  95      


Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn 
            100                 105                 110         


Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr 
        115                 120                 125             


Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly 
    130                 135                 140                 


Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg 
145                 150                 155 


<210>  5
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(129)
<223>  Human Prothrombin Activation Fragment 2

<400>  5

Ser Glu Gly Ser Ser Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val 
1               5                   10                  15      


Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His 
            20                  25                  30          


Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser 
        35                  40                  45              


Lys His Gln Asp Phe Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys 
    50                  55                  60                  


Arg Asn Pro Asp Gly Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly 
65                  70                  75                  80  


Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala 
                85                  90                  95      


Val Glu Glu Glu Thr Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala 
            100                 105                 110         


Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro 
        115                 120                 125             


Arg 
    


<210>  6
<211>  622
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(622)
<223>  Human Prothrombin

<400>  6

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


