                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  ACID-RESISTANT, ATTENUATED MICROBIAL VECTOR FOR IMPROVED ORAL 
       DELIVERY OF MULTIPLE TARGETED ANTIGENS

<130>  6137FDA-11-PCT

<140>  61862875
<141>  2013-08-06

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  9175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  1
gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg       60

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc      120

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt      180

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg      240

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg      300

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa      360

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa      420

atcccttaac gtgagttttc gttccactga gcgtcagacc ccttaataag atgatcttct      480

tgagatcgtt ttggtctgcg cgtaatctct tgctctgaaa acgaaaaaac cgccttgcag      540

ggcggttttt cgaaggttct ctgagctacc aactctttga accgaggtaa ctggcttgga      600

ggagcgcagt caccaaaact tgtcctttca gtttagcctt aaccggcgca tgacttcaag      660

actaactcct ctaaatcaat taccagtggc tgctgccagt ggtgcttttg catgtctttc      720

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcggact gaacgggggg      780

ttcgtgcata cagtccagct tggagcgaac tgcctacccg gaactgagtg tcaggcgtgg      840

aatgagacaa acgcggccat aacagcggaa tgacaccggt aaaccgaaag gcaggaacag      900

gagagcgcac gagggagccg ccagggggaa acgcctggta tctttatagt cctgtcgggt      960

ttcgccacca ctgatttgag cgtcagattt cgtgatgctt gtcagggggg cggagcctat     1020

ggaaaaacgg ctttgccgcg gccctctcac ttccctgtta agtatcttcc tggcatcttc     1080

caggaaatct ccgccccgtt cgtaagccat ttccgctcgc cgcagtcgaa cgaccgagcg     1140

tagcgagtca gtgagcgagg aagcggaata tatcctgtat cacatattct gctgacgcac     1200

cggtgcagcc ttttttctcc tgccacatga agcacttcac tgacaccctc atcagtgcca     1260

acatagtaag ccagtataca ctccgctagc gctgaggtct gcctcgtgaa gaaggtgttg     1320

ctgactcata ccaggcctga atcgccccat catccagcca gaaagtgagg gagccacggt     1380

tgatgagagc tttgttgtag gtggaccagt tggtgatttt gaacttttgc tttgccacgg     1440

aacggtctgc gttgtcggga agatgcgtga tctgatcctt caactcagca aaagttcgat     1500

ttattcaaca aagccacgtt gtgtctcaaa atctctgatg ttacattgca caagataaaa     1560

atatatcatc atgaacaata aaactgtctg cttacataaa cagtaataca aggggtgtta     1620

tgagccatat tcaacgggaa acgtcttgct cgaggccgcg attaaattcc aacatggatg     1680

ctgatttata tgggtataaa tgggctcgcg ataatgtcgg gcaatcaggt gcgacaatct     1740

atcgattgta tgggaagccc gatgcgccag agttgtttct gaaacatggc aaaggtagcg     1800

ttgccaatga tgttacagat gagatggtca gactaaactg gctgacggaa tttatgcctc     1860

ttccgaccat caagcatttt atccgtactc ctgatgatgc atggttactc accactgcga     1920

tccccgggaa aacagcattc caggtattag aagaatatcc tgattcaggt gaaaatattg     1980

ttgatgcgct ggcagtgttc ctgcgccggt tgcattcgat tcctgtttgt aattgtcctt     2040

ttaacagcga tcgcgtattt cgtctcgctc aggcgcaatc acgaatgaat aacggtttgg     2100

ttgatgcgag tgattttgat gacgagcgta atggctggcc tgttgaacaa gtctggaaag     2160

aaatgcataa gcttttgcca ttctcaccgg attcagtcgt cactcatggt gatttctcac     2220

ttgataacct tatttttgac gaggggaaat taataggttg tattgatgtt ggacgagtcg     2280

gaatcgcaga ccgataccag gatcttgcca tcctatggaa ctgcctcggt gagttttctc     2340

cttcattaca gaaacggctt tttcaaaaat atggtattga taatcctgat atgaataaat     2400

tgcagtttca tttgatgctc gatgagtttt tctaatcaga attggttaat tggttgtaac     2460

actggcagag cattacgctg acttgacggg acggcggctt tgttgaataa atcgaacttt     2520

tgctgagttg aaggatcaga tcacgcatct tcccgacaac gcagaccgtt ccgtggcaaa     2580

gcaaaagttc aaaatcacca actggtccac ctacaacaaa gctctcatca accgtggctc     2640

cctcactttc tggctggatg atggggcgat tcaggcctgg tatgagtcag caacaccttc     2700

ttcacgaggc agacctcagc gctcaaagat gcaggggtaa aagctaaccg catctttacc     2760

gacaaggcat ccggcagttc aacagatcgg gaagggctgg atttgctgag gatgaaggtg     2820

gaggaaggtg atgtcattct ggtgaagaag ctcgaccgtc ttggccgcga caccgccgac     2880

atgatccaac tgataaaaga gtttgatgct cagggtgtag cggttcggtt tattgacgac     2940

gggatcagta ccgacggtga tatggggcaa atggtggtca ccatcctgtc ggctgtggca     3000

caggctgaac gccggaggat ctgccgtcaa ttgtctgatt cgttaccaat tatgacaact     3060

tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc gggctggccc     3120

cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca acattgcgac     3180

cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg ctgatacgtt     3240

ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga tgtgacagac     3300

gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg ctgtctgcca     3360

ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt ggatggagcg     3420

actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt atcgccagca     3480

gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac aggtcgctga     3540

aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat attgacggcc     3600

agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg tgataccatt     3660

cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac agcaaaatat     3720

cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga ccgcgaatgg     3780

tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa tcgagataac     3840

cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag tatcccggca     3900

gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc agagaagaaa     3960

ccaattgtcc atattgcatc agacattgcc gtcactgcgt cttttactgg ctcttctcgc     4020

taaccaaacc ggtaaccccg cttattaaaa gcattctgta acaaagcggg accaaagcca     4080

tgacaaaaac gcgtaacaaa agtgtctata atcacggcag aaaagtccac attgattatt     4140

tgcacggcgt cacactttgc tatgccatag catttttatc cataagatta gcggatccta     4200

cctgacgctt tttatcgcaa ctctctactg tttctccata cccgtttttt tggatggagt     4260

gaaacgatgg accagaagct gttaacggat ttccgctcag aactactcga ttcacgtttt     4320

ggcgcaaagg ccatttctac tatcgcggag tcaaaacgat ttccgctgca cgaaatgcgc     4380

gatgatgtcg cattccagat tatcaatgat gaattatatc ttgatggcaa cgctcgtcag     4440

aacctagcca ctttctgcca gacctgggac gacgaaaacg tccataaatt gatggatttg     4500

tcgatcaata aaaactggat cgacaaagaa gaatatccgc aatccgcagc catcgacctg     4560

cgttgcgtaa atatggttgc cgatctgtgg catgcgcctg cgccgaaaaa tggtcaggcc     4620

gttggcacca acaccattgg ttcttccgag gcctgtatgc tcggcgggat ggcgatgaaa     4680

tggcgttggc gcaagcgtat ggaagctgca ggcaaaccaa cggataaacc aaacctagtg     4740

tgcggtccgg tacaaatctg ctggcataaa ttcgcccgct actgggatgt ggagctgcgt     4800

gagatcccta tgcgccccgg tcagttgttt atggacccga aacgcatgat tgaagcctgt     4860

gacgaaaaca ccatcggcgt ggtgccgact ttcggcgtga cctacaccgg taactatgag     4920

ttcccacaac cgctgcacga tgcgctggat aaattccagg ccgacaccgg tatcgacatc     4980

gacatgcaca tcgacgctgc cagcggtggc ttcctggcac cgttcgtcgc cccggatatc     5040

gtctgggact tccgcctgcc gcgtgtgaaa tcgatcagtg cttcaggcca taaattcggt     5100

ctggctccgc tgggctgcgg ctgggttatc tggcgtgacg aagaagcgct gccgcaggaa     5160

ctggtgttca acgttgacta cctgggtggt caaattggta cttttgccat caacttctcc     5220

cgcccggcgg gtcaggtaat tgcacagtac tatgaattcc tgcgcctcgg tcgtgaaggc     5280

tataccaaag tacagaacgc ctcttaccag gttgccgctt atctggcgga tgaaatcgcc     5340

aaacaggggc cgtatgagtt catctgtacg ggtcgcccgg acgaaggcat cccggcggtt     5400

tgcttcaaac tgaaagatgg tgaagatccg ggatacaccc tgtacgacct ctctgaacgt     5460

ctgcgtctgc gcggctggca ggttccggcc ttcactctcg gcggtgaagc caccgacatc     5520

gtggtgatgc gcattatgtg tcgtcgcggc ttcgaaatgg actttgctga actgttgctg     5580

gaagactaca aagcctccct gaaatatctc agcgatcacc cgaaactgca gggtattgcc     5640

cagcagaaca gctttaaaca cacctgacct acttggagtg ttttaatgcg atccaatcat     5700

tttaaggagt ttaaaatgga taagaagcaa gtaacggatt taaggtcgga actactcgat     5760

tcacgttttg gtgcgaagtc tatttccact atcgcagaat caaaacgttt tccgctgcac     5820

gaaatgcgcg acgatgtcgc atttcagatt atcaatgatg aattatatct tgatggcaac     5880

gctcgtcaga acctggccac tttctgccag acctgggacg acgaaaacgt ccacaagttg     5940

atggatttat ccattaacaa aaactggatc gacaaagaag aatatccgca atccgcagcc     6000

atcgacctgc gttgcgtaaa catggttgcc gatctgtggc atgcgcctgc gccgaaaaat     6060

ggtcaggccg ttggcaccaa caccattggt tcttccgagg cctgtatgct cggcgggatg     6120

gcgatgaaat ggcgttggcg caagcgtatg gaagctgcag gcaaaccaac ggataaacca     6180

aacctggtgt gcggtccggt gcaaatctgc tggcataaat tcgcccgcta ctgggatgtg     6240

gagctgcgtg agatccctat gcgccccggt cagttgttta tggacccgaa acgcatgatt     6300

gaagcctgcg acgaaaatac catcggcgtg gtgccgactt tcggcgtgac ctacaccggt     6360

aactatgagt tcccgcaacc gctgcacgat gcactggata aattccaggc cgacaccggt     6420

atcgacatcg acatgcacat cgacgccgcc agcggtggct ttctggcacc gttcgtcgcc     6480

ccggatatcg tctgggactt ccgcctgccg cgtgtgaaat cgatcagtgc ttcaggccat     6540

aaattcggtc tggctccgct gggctgcggc tgggttatct ggcgtgacga agaagcgctg     6600

ccgcaggaac tggtgttcaa cgttgactac ctcggtggtc agattggtac ttttgccatc     6660

aacttctccc gcccggcggg tcaggtgatt gcacagtact atgaattcct gcgccttggt     6720

cgtgaaggct ataccaaagt acagaatgct tcctaccagg tcgctgccta tctggcggat     6780

gagatcgcca aactggggcc gtatgagttc atctgtaccg gtcgcccgga cgaaggcatc     6840

ccggcggttt gcttcaaact gaaagatggt gaagatccgg gatacaccct gtacgacctc     6900

tctgaacgtc tgcgtctgcg cggctggcag gttccggcct tcactctcgg cggtgaagcc     6960

accgacatcg tggtgatgcg cattatgtgt cgtcgcggct tcgaaatgga ctttgctgaa     7020

ctgttgctgg aagactacaa agcctccctg aaatatctca gcgatcaccc gaaactgcag     7080

ggtattgccc agcagaacag ctttaaacat acctgataac cgttttggag tgataatatg     7140

gctacatcag tacagacagg taaagctaag cagctcacat tactcggatt ctttgccata     7200

acggcatcga tggtaatggc tgtttatgaa taccctacct tcgcaacatc gggcttttca     7260

ttagtcttct tcctgctatt aggcgggatt ttatggttta ttcccgtggg actttgtgct     7320

gcggaaatgg ccaccgtcga cggctgggaa gaaggtggtg tcttcgcctg ggtatcaaat     7380

actctgggtc cgagatgggg atttgcagcg atctcatttg gctatctgca aatcgccatt     7440

ggttttattc cgatgctcta tttcgtgtta ggggcactct cctacatcct gaaatggcca     7500

gcgctgaatg aagaccccat taccaaaact attgcagcac tcatcattct ttgggcgctg     7560

gcattaacgc agtttggtgg cacgaaatac acggcgcgaa ttgctaaagt tggcttcttc     7620

gccggtatcc tgttacctgc atttattttg atcgcattag cggctattta cctgcactcc     7680

ggtgcccccg ttgctatcga aatggattcg aagaccttct tccctgactt ctctaaagtg     7740

ggcacactgg ttgtatttgt tgccttcatt ttgagttata tgggcgtaga agcttccgca     7800

actcacgtca atgaaatgag caaccccggg cgcgactatc cactggctat gttactgctg     7860

atggtggcgg caatctgctt aagctctgtt ggcggtttgt ctattgcgat ggtcattccg     7920

ggtaatgaaa tcaacctctc cgcaggggta atgcaaacct ttaccgttct gatgtcccat     7980

gtggcaccgg aaattgagtg gacggttcgc gtgatctccg cactgctgtt gctgggtgtt     8040

ctggcggaaa tcgcctcctg gattgttggt ccttctcgcg ggatgtatgt cacagcgcag     8100

aaaaacctgc tgccagcggc attcgctaaa atgaacaaaa atggcgtacc ggtaacgctg     8160

gtcatttcgc agctggtgat tacttctatc gcgttgatca tcctcaccaa taccggtggc     8220

ggtaacaaca tgtccttcct gatcgcactg gcgctgacgg tggtgattta tctgtgtgct     8280

tatttcatgc tgtttattgg ctacattgtg ttggttctta aacatcctga cttaaaacgc     8340

acatttaata tccctggtgg taaaggggtg aaactggtcg tggcaattgt cggtctgctg     8400

acttcaatta tggcgtttat tgtttccttc ctgccgccgg ataacatcca gggtgattct     8460

accgatatgt atgttgaatt actggttgtt agtttcctgg tggtacttgc cctgcccttt     8520

attctctatg ctgttcatga tcgtaaaggc aaagcgaata ccggcgtcac tctggagcca     8580

atcaacagtc agaacgcacc aaaaggtcac ttcttcctgc acccgcgtgc acgttcacca     8640

cactatattg tgatgaatga caagaaacac taatctagag tcgacctgca ggcatgcaag     8700

cttggctgtt ttggcggatg agagaagatt ttcagcctga tacagattaa atcagaacgc     8760

agaagcggtc tgataaaaca gaatttgcct ggcggcagta gcgcggtggt cccacctgac     8820

cccatgccga actcagaagt gaaacgccgt agcgccgatg gtagtgtggg gtctccccat     8880

gcgagagtag ggaactgcca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc     8940

ctttcgtttt atctgttgtt tgtcggtgaa cgctctcctg agtaggacaa atccgccggg     9000

agcggatttg aacgttgcga agcaacggcc cggagggtgg cgggcaggac gcccgccata     9060

aactgccagg catcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtttct     9120

acaaactctt ttgtttattt ttctaaatac attcaaatat gtatccgctc atgca          9175


<210>  2
<211>  8343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  2
cacgcaatat ttcaatgatg gcaacgcatt ctctgaagct ttccatgccg gcattcaatc       60

gcagcgccta aatgatacgt ttatggaaac ggcgttatct ttggcaatca aattcagtga      120

tgaattgatt ttcatgcatg cgctcgagca gctactccgc catgagtcag aatttgcgct      180

gacggtattg tcgacgattc atgataccgg tctcgttatc cgcacagctt tctgcatcaa      240

gaatatgagc tatcatcaag cgcttcgcac ctcgtataaa gataaaatcc acgacgtttt      300

tgaggcatgg aacaataccg cgctgtcgct acattcggtt gatgattttg tctcactgag      360

tacttcgcta gcctatagct actctgcatt tatggtttat ccccattcac gtatttctcg      420

ctttaataat gaagttaaaa tggcatggcg cgataaatta agagaaatgt atgagcgtga      480

ggattatgaa aatatcctgg caggggcgaa aatagtgtgg ccacttctga agtttgatcc      540

cgttggcacc gtatattgtg caagaacgct ggtgaatctt ggtgcctgga aagacgcgtg      600

cacgttggcc cacatgacct tgattcgtaa ctcgaacatt accagcctgc agtcgattat      660

gttacgcagc atacgtcata ttaacaacat tccgttcctc attgatttga ttgctaacgt      720

catgagcatt actctatcat tccagaatgc ctcaatgaac aagttgtttg agaaagagtg      780

tcgcaatgtt gcaaccagag cccttaaata tgtacgccag aagaaaactg aagggcgtct      840

ggatgaagca ttgtctgtat tgattagcct gaaacgaatt gagcctgatg tttctcgtct      900

gatgcgtgaa tataagcaaa ttatcagatt atttaatgag tcacggaagg atggcggtag      960

cactatcacg tcttatgaac atctagacta tgcgaaaaaa ttactcgttt ttgatagcga     1020

aaatgcctat gccttgaaat atgccgcatt aaatgcaatg catttacgcg actacacgca     1080

ggctttgcag tattggcagc gactggagaa agtgaatgga ccaacggagc cggtgacaag     1140

gcagatctcg acctgcataa ccgcattaca aaaaaataca tcagggaagt cgtaacccgg     1200

gaccggtgga tccactctcg aggccggagg atctgccgtc aattgtctga ttcgttacca     1260

attatgacaa cttgacggct acatcattca ctttttcttc acaaccggca cggaactcgc     1320

tcgggctggc cccggtgcat tttttaaata cccgcgagaa atagagttga tcgtcaaaac     1380

caacattgcg accgacggtg gcgataggca tccgggtggt gctcaaaagc agcttcgcct     1440

ggctgatacg ttggtcctcg cgccagctta agacgctaat ccctaactgc tggcggaaaa     1500

gatgtgacag acgcgacggc gacaagcaaa catgctgtgc gacgctggcg atatcaaaat     1560

tgctgtctgc caggtgatcg ctgatgtact gacaagcctc gcgtacccga ttatccatcg     1620

gtggatggag cgactcgtta atcgcttcca tgcgccgcag taacaattgc tcaagcagat     1680

ttatcgccag cagctccgaa tagcgccctt ccccttgccc ggcgttaatg atttgcccaa     1740

acaggtcgct gaaatgcggc tggtgcgctt catccgggcg aaagaacccc gtattggcaa     1800

atattgacgg ccagttaagc cattcatgcc agtaggcgcg cggacgaaag taaacccact     1860

ggtgatacca ttcgcgagcc tccggatgac gaccgtagtg atgaatctct cctggcggga     1920

acagcaaaat atcacccggt cggcaaacaa attctcgtcc ctgatttttc accaccccct     1980

gaccgcgaat ggtgagattg agaatataac ctttcattcc cagcggtcgg tcgataaaaa     2040

aatcgagata accgttggcc tcaatcggcg ttaaacccgc caccagatgg gcattaaacg     2100

agtatcccgg cagcagggga tcattttgcg cttcagccat acttttcata ctcccgccat     2160

tcagagaaga aaccaattgt ccatattgca tcagacattg ccgtcactgc gtcttttact     2220

ggctcttctc gctaaccaaa ccggtaaccc cgcttattaa aagcattctg taacaaagcg     2280

ggaccaaagc catgacaaaa acgcgtaaca aaagtgtcta taatcacggc agaaaagtcc     2340

acattgatta tttgcacggc gtcacacttt gctatgccat agcattttta tccataagat     2400

tagcggatcc tacctgacgc tttttatcgc aactctctac tgtttctcca tacccgtttt     2460

tttggatgga gtgaaacgat ggaccagaag ctgttaacgg atttccgctc agaactactc     2520

gattcacgtt ttggcgcaaa ggccatttct actatcgcgg agtcaaaacg atttccgctg     2580

cacgaaatgc gcgatgatgt cgcattccag attatcaatg atgaattata tcttgatggc     2640

aacgctcgtc agaacctagc cactttctgc cagacctggg acgacgaaaa cgtccataaa     2700

ttgatggatt tgtcgatcaa taaaaactgg atcgacaaag aagaatatcc gcaatccgca     2760

gccatcgacc tgcgttgcgt aaatatggtt gccgatctgt ggcatgcgcc tgcgccgaaa     2820

aatggtcagg ccgttggcac caacaccatt ggttcttccg aggcctgtat gctcggcggg     2880

atggcgatga aatggcgttg gcgcaagcgt atggaagctg caggcaaacc aacggataaa     2940

ccaaacctag tgtgcggtcc ggtacaaatc tgctggcata aattcgcccg ctactgggat     3000

gtggagctgc gtgagatccc tatgcgcccc ggtcagttgt ttatggaccc gaaacgcatg     3060

attgaagcct gtgacgaaaa caccatcggc gtggtgccga ctttcggcgt gacctacacc     3120

ggtaactatg agttcccaca accgctgcac gatgcgctgg ataaattcca ggccgacacc     3180

ggtatcgaca tcgacatgca catcgacgct gccagcggtg gcttcctggc accgttcgtc     3240

gccccggata tcgtctggga cttccgcctg ccgcgtgtga aatcgatcag tgcttcaggc     3300

cataaattcg gtctggctcc gctgggctgc ggctgggtta tctggcgtga cgaagaagcg     3360

ctgccgcagg aactggtgtt caacgttgac tacctgggtg gtcaaattgg tacttttgcc     3420

atcaacttct cccgcccggc gggtcaggta attgcacagt actatgaatt cctgcgcctc     3480

ggtcgtgaag gctataccaa agtacagaac gcctcttacc aggttgccgc ttatctggcg     3540

gatgaaatcg ccaaacaggg gccgtatgag ttcatctgta cgggtcgccc ggacgaaggc     3600

atcccggcgg tttgcttcaa actgaaagat ggtgaagatc cgggatacac cctgtacgac     3660

ctctctgaac gtctgcgtct gcgcggctgg caggttccgg ccttcactct cggcggtgaa     3720

gccaccgaca tcgtggtgat gcgcattatg tgtcgtcgcg gcttcgaaat ggactttgct     3780

gaactgttgc tggaagacta caaagcctcc ctgaaatatc tcagcgatca cccgaaactg     3840

cagggtattg cccagcagaa cagctttaaa cacacctgac ctacttggag tgttttaatg     3900

cgatccaatc attttaagga gtttaaaatg gataagaagc aagtaacgga tttaaggtcg     3960

gaactactcg attcacgttt tggtgcgaag tctatttcca ctatcgcaga atcaaaacgt     4020

tttccgctgc acgaaatgcg cgacgatgtc gcatttcaga ttatcaatga tgaattatat     4080

cttgatggca acgctcgtca gaacctggcc actttctgcc agacctggga cgacgaaaac     4140

gtccacaagt tgatggattt atccattaac aaaaactgga tcgacaaaga agaatatccg     4200

caatccgcag ccatcgacct gcgttgcgta aacatggttg ccgatctgtg gcatgcgcct     4260

gcgccgaaaa atggtcaggc cgttggcacc aacaccattg gttcttccga ggcctgtatg     4320

ctcggcggga tggcgatgaa atggcgttgg cgcaagcgta tggaagctgc aggcaaacca     4380

acggataaac caaacctggt gtgcggtccg gtgcaaatct gctggcataa attcgcccgc     4440

tactgggatg tggagctgcg tgagatccct atgcgccccg gtcagttgtt tatggacccg     4500

aaacgcatga ttgaagcctg cgacgaaaat accatcggcg tggtgccgac tttcggcgtg     4560

acctacaccg gtaactatga gttcccgcaa ccgctgcacg atgcactgga taaattccag     4620

gccgacaccg gtatcgacat cgacatgcac atcgacgccg ccagcggtgg ctttctggca     4680

ccgttcgtcg ccccggatat cgtctgggac ttccgcctgc cgcgtgtgaa atcgatcagt     4740

gcttcaggcc ataaattcgg tctggctccg ctgggctgcg gctgggttat ctggcgtgac     4800

gaagaagcgc tgccgcagga actggtgttc aacgttgact acctcggtgg tcagattggt     4860

acttttgcca tcaacttctc ccgcccggcg ggtcaggtga ttgcacagta ctatgaattc     4920

ctgcgccttg gtcgtgaagg ctataccaaa gtacagaatg cttcctacca ggtcgctgcc     4980

tatctggcgg atgagatcgc caaactgggg ccgtatgagt tcatctgtac cggtcgcccg     5040

gacgaaggca tcccggcggt ttgcttcaaa ctgaaagatg gtgaagatcc gggatacacc     5100

ctgtacgacc tctctgaacg tctgcgtctg cgcggctggc aggttccggc cttcactctc     5160

ggcggtgaag ccaccgacat cgtggtgatg cgcattatgt gtcgtcgcgg cttcgaaatg     5220

gactttgctg aactgttgct ggaagactac aaagcctccc tgaaatatct cagcgatcac     5280

ccgaaactgc agggtattgc ccagcagaac agctttaaac atacctgata accgttttgg     5340

agtgataata tggctacatc agtacagaca ggtaaagcta agcagctcac attactcgga     5400

ttctttgcca taacggcatc gatggtaatg gctgtttatg aataccctac cttcgcaaca     5460

tcgggctttt cattagtctt cttcctgcta ttaggcggga ttttatggtt tattcccgtg     5520

ggactttgtg ctgcggaaat ggccaccgtc gacggctggg aagaaggtgg tgtcttcgcc     5580

tgggtatcaa atactctggg tccgagatgg ggatttgcag cgatctcatt tggctatctg     5640

caaatcgcca ttggttttat tccgatgctc tatttcgtgt taggggcact ctcctacatc     5700

ctgaaatggc cagcgctgaa tgaagacccc attaccaaaa ctattgcagc actcatcatt     5760

ctttgggcgc tggcattaac gcagtttggt ggcacgaaat acacggcgcg aattgctaaa     5820

gttggcttct tcgccggtat cctgttacct gcatttattt tgatcgcatt agcggctatt     5880

tacctgcact ccggtgcccc cgttgctatc gaaatggatt cgaagacctt cttccctgac     5940

ttctctaaag tgggcacact ggttgtattt gttgccttca ttttgagtta tatgggcgta     6000

gaagcttccg caactcacgt caatgaaatg agcaaccccg ggcgcgacta tccactggct     6060

atgttactgc tgatggtggc ggcaatctgc ttaagctctg ttggcggttt gtctattgcg     6120

atggtcattc cgggtaatga aatcaacctc tccgcagggg taatgcaaac ctttaccgtt     6180

ctgatgtccc atgtggcacc ggaaattgag tggacggttc gcgtgatctc cgcactgctg     6240

ttgctgggtg ttctggcgga aatcgcctcc tggattgttg gtccttctcg cgggatgtat     6300

gtcacagcgc agaaaaacct gctgccagcg gcattcgcta aaatgaacaa aaatggcgta     6360

ccggtaacgc tggtcatttc gcagctggtg attacttcta tcgcgttgat catcctcacc     6420

aataccggtg gcggtaacaa catgtccttc ctgatcgcac tggcgctgac ggtggtgatt     6480

tatctgtgtg cttatttcat gctgtttatt ggctacattg tgttggttct taaacatcct     6540

gacttaaaac gcacatttaa tatccctggt ggtaaagggg tgaaactggt cgtggcaatt     6600

gtcggtctgc tgacttcaat tatggcgttt attgtttcct tcctgccgcc ggataacatc     6660

cagggtgatt ctaccgatat gtatgttgaa ttactggttg ttagtttcct ggtggtactt     6720

gccctgccct ttattctcta tgctgttcat gatcgtaaag gcaaagcgaa taccggcgtc     6780

actctggagc caatcaacag tcagaacgca ccaaaaggtc acttcttcct gcacccgcgt     6840

gcacgttcac cacactatat tgtgatgaat gacaagaaac actaatctag agtcgacctg     6900

caggcatgca agcttggggt accgaattct gaagttccta tactttctag agaataggaa     6960

cttcggaata ggaactaagg aggatattca tatcaaaaaa atcatcatat tactaacgac     7020

atttttcctg ctttcgggat gcactattcc cagggcggta tttaaatcca gccttattaa     7080

tcaggacgat cctcgttata atctggtcga agtcacgccg acattaaaac taagcgctcc     7140

cgatactgtg ccgaaaacta ttgtcgatcc ggtttttgcc gcaaataact ggcactggac     7200

atctttggct aaaggcgatg tgctgcatat cactatttta tcctcgggcg gggctggata     7260

tttatccaat aacgcgagcg gcgaccgtgc ggattttgaa aatattcttg tgactgacag     7320

taataccgtt caggtgcctt atgccgggac aatcccggtt tctggattgg atgtgacgca     7380

actggctgat gagatcaaaa agcgactttc gcgcgttgtc ctgaatcctc aggtgattgt     7440

gacacttacc gcccgcaccg gagccatggt gacggtcgag ggcagcggga aaacgggtcg     7500

ataccctctc gaacagagta tgaatcgtct gagtcatctt ttggcaacgg cagtggcagt     7560

agaaaatacc agcacagata tgatggaagt tcacgtgacg cgccagcagc attatttcac     7620

tgcgcgactg tcagatattt atcagtatcc cggattggat attgccttac agccggatga     7680

ccgtatcact ctgcgtcaag tgaccgagta tgttaatgtg ctcggcgcag caggtgttca     7740

ggggaaacat gctctggttc agcgtcattc cagcgtcgtg gatgctttgg cgctcgcgaa     7800

aggattaaat gacaatcttg ccgatccgca agcgattttt ctgtacaagc ataacgaagc     7860

ggaacaggcg aaacagcaga tgcgtaagct gaatatctat catgtcgata tgagccaacc     7920

taactcggtg tttttagcgc aggccatacg agtggacaac ggcgatgtta tctatatctc     7980

gaacgcctct ttgactgatt tcgctaaggt gaaagccgca ttcgatagct ttttgacccg     8040

cggcactaat tctttctaat gtcgccatat gaatattttg aaaaataatt cttattattt     8100

tatgaaactc attaccgtct gtgagttaat tattttattg atgtcacgcg atatcaaaac     8160

acgctataac ggtaatttac taaactatat gatggtgctg gccgtaccac tggtatggat     8220

atccattacc gttatttctt ttcaatattt aaatcgctcg gtgccaatat ccactgacga     8280

tatcagtttt gttattgcag ggatattacc gtatctgtta tttcgttata ccattaccgc     8340

aac                                                                   8343


<210>  3
<211>  1401
<212>  DNA
<213>  Shigella flexneri

<400>  3
atggaccaga agctgttaac ggatttccgc tcagaactac tcgattcacg ttttggcgca       60

aaggccattt ctactatcgc ggagtcaaaa cgatttccgc tgcacgaaat gcgcgatgat      120

gtcgcattcc agattatcaa tgatgaatta tatcttgatg gcaacgctcg tcagaaccta      180

gccactttct gccagacctg ggacgacgaa aacgtccata aattgatgga tttgtcgatc      240

aataaaaact ggatcgacaa agaagaatat ccgcaatccg cagccatcga cctgcgttgc      300

gtaaatatgg ttgccgatct gtggcatgcg cctgcgccga aaaatggtca ggccgttggc      360

accaacacca ttggttcttc cgaggcctgt atgctcggcg ggatggcgat gaaatggcgt      420

tggcgcaagc gtatggaagc tgcaggcaaa ccaacggata aaccaaacct agtgtgcggt      480

ccggtacaaa tctgctggca taaattcgcc cgctactggg atgtggagct gcgtgagatc      540

cctatgcgcc ccggtcagtt gtttatggac ccgaaacgca tgattgaagc ctgtgacgaa      600

aacaccatcg gcgtggtgcc gactttcggc gtgacctaca ccggtaacta tgagttccca      660

caaccgctgc acgatgcgct ggataaattc caggccgaca ccggtatcga catcgacatg      720

cacatcgacg ctgccagcgg tggcttcctg gcaccgttcg tcgccccgga tatcgtctgg      780

gacttccgcc tgccgcgtgt gaaatcgatc agtgcttcag gccataaatt cggtctggct      840

ccgctgggct gcggctgggt tatctggcgt gacgaagaag cgctgccgca ggaactggtg      900

ttcaacgttg actacctggg tggtcaaatt ggtacttttg ccatcaactt ctcccgcccg      960

gcgggtcagg taattgcaca gtactatgaa ttcctgcgcc tcggtcgtga aggctatacc     1020

aaagtacaga acgcctctta ccaggttgcc gcttatctgg cggatgaaat cgccaaacag     1080

gggccgtatg agttcatctg tacgggtcgc ccggacgaag gcatcccggc ggtttgcttc     1140

aaactgaaag atggtgaaga tccgggatac accctgtacg acctctctga acgtctgcgt     1200

ctgcgcggct ggcaggttcc ggccttcact ctcggcggtg aagccaccga catcgtggtg     1260

atgcgcatta tgtgtcgtcg cggcttcgaa atggactttg ctgaactgtt gctggaagac     1320

tacaaagcct ccctgaaata tctcagcgat cacccgaaac tgcagggtat tgcccagcag     1380

aacagcttta aacacacctg a                                               1401


<210>  4
<211>  1431
<212>  DNA
<213>  Shigella flexneri

<400>  4
atgcgatcca atcattttaa ggagtttaaa atggataaga agcaagtaac ggatttaagg       60

tcggaactac tcgattcacg ttttggtgcg aagtctattt ccactatcgc agaatcaaaa      120

cgttttccgc tgcacgaaat gcgcgacgat gtcgcatttc agattatcaa tgatgaatta      180

tatcttgatg gcaacgctcg tcagaacctg gccactttct gccagacctg ggacgacgaa      240

aacgtccaca agttgatgga tttatccatt aacaaaaact ggatcgacaa agaagaatat      300

ccgcaatccg cagccatcga cctgcgttgc gtaaacatgg ttgccgatct gtggcatgcg      360

cctgcgccga aaaatggtca ggccgttggc accaacacca ttggttcttc cgaggcctgt      420

atgctcggcg ggatggcgat gaaatggcgt tggcgcaagc gtatggaagc tgcaggcaaa      480

ccaacggata aaccaaacct ggtgtgcggt ccggtgcaaa tctgctggca taaattcgcc      540

cgctactggg atgtggagct gcgtgagatc cctatgcgcc ccggtcagtt gtttatggac      600

ccgaaacgca tgattgaagc ctgcgacgaa aataccatcg gcgtggtgcc gactttcggc      660

gtgacctaca ccggtaacta tgagttcccg caaccgctgc acgatgcact ggataaattc      720

caggccgaca ccggtatcga catcgacatg cacatcgacg ccgccagcgg tggctttctg      780

gcaccgttcg tcgccccgga tatcgtctgg gacttccgcc tgccgcgtgt gaaatcgatc      840

agtgcttcag gccataaatt cggtctggct ccgctgggct gcggctgggt tatctggcgt      900

gacgaagaag cgctgccgca ggaactggtg ttcaacgttg actacctcgg tggtcagatt      960

ggtacttttg ccatcaactt ctcccgcccg gcgggtcagg tgattgcaca gtactatgaa     1020

ttcctgcgcc ttggtcgtga aggctatacc aaagtacaga atgcttccta ccaggtcgct     1080

gcctatctgg cggatgagat cgccaaactg gggccgtatg agttcatctg taccggtcgc     1140

ccggacgaag gcatcccggc ggtttgcttc aaactgaaag atggtgaaga tccgggatac     1200

accctgtacg acctctctga acgtctgcgt ctgcgcggct ggcaggttcc ggccttcact     1260

ctcggcggtg aagccaccga catcgtggtg atgcgcatta tgtgtcgtcg cggcttcgaa     1320

atggactttg ctgaactgtt gctggaagac tacaaagcct ccctgaaata tctcagcgat     1380

cacccgaaac tgcagggtat tgcccagcag aacagcttta aacatacctg a              1431


<210>  5
<211>  1536
<212>  DNA
<213>  Shigella flexneri

<400>  5
atggctacat cagtacagac aggtaaagct aagcagctca cattactcgg attctttgcc       60

ataacggcat cgatggtaat ggctgtttat gaatacccta ccttcgcaac atcgggcttt      120

tcattagtct tcttcctgct attaggcggg attttatggt ttattcccgt gggactttgt      180

gctgcggaaa tggccaccgt cgacggctgg gaagaaggtg gtgtcttcgc ctgggtatca      240

aatactctgg gtccgagatg gggatttgca gcgatctcat ttggctatct gcaaatcgcc      300

attggtttta ttccgatgct ctatttcgtg ttaggggcac tctcctacat cctgaaatgg      360

ccagcgctga atgaagaccc cattaccaaa actattgcag cactcatcat tctttgggcg      420

ctggcattaa cgcagtttgg tggcacgaaa tacacggcgc gaattgctaa agttggcttc      480

ttcgccggta tcctgttacc tgcatttatt ttgatcgcat tagcggctat ttacctgcac      540

tccggtgccc ccgttgctat cgaaatggat tcgaagacct tcttccctga cttctctaaa      600

gtgggcacac tggttgtatt tgttgccttc attttgagtt atatgggcgt agaagcttcc      660

gcaactcacg tcaatgaaat gagcaacccc gggcgcgact atccactggc tatgttactg      720

ctgatggtgg cggcaatctg cttaagctct gttggcggtt tgtctattgc gatggtcatt      780

ccgggtaatg aaatcaacct ctccgcaggg gtaatgcaaa cctttaccgt tctgatgtcc      840

catgtggcac cggaaattga gtggacggtt cgcgtgatct ccgcactgct gttgctgggt      900

gttctggcgg aaatcgcctc ctggattgtt ggtccttctc gcgggatgta tgtcacagcg      960

cagaaaaacc tgctgccagc ggcattcgct aaaatgaaca aaaatggcgt accggtaacg     1020

ctggtcattt cgcagctggt gattacttct atcgcgttga tcatcctcac caataccggt     1080

ggcggtaaca acatgtcctt cctgatcgca ctggcgctga cggtggtgat ttatctgtgt     1140

gcttatttca tgctgtttat tggctacatt gtgttggttc ttaaacatcc tgacttaaaa     1200

cgcacattta atatccctgg tggtaaaggg gtgaaactgg tcgtggcaat tgtcggtctg     1260

ctgacttcaa ttatggcgtt tattgtttcc ttcctgccgc cggataacat ccagggtgat     1320

tctaccgata tgtatgttga attactggtt gttagtttcc tggtggtact tgccctgccc     1380

tttattctct atgctgttca tgatcgtaaa ggcaaagcga ataccggcgt cactctggag     1440

ccaatcaaca gtcagaacgc accaaaaggt cacttcttcc tgcacccgcg tgcacgttca     1500

ccacactata ttgtgatgaa tgacaagaaa cactaa                               1536


<210>  6
<211>  3690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  6
agattgcagc attacacgtc ttgagcgatt gtgtaggctg gagctgcttc aagatcccct       60

cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag      120

ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa      180

gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc      240

tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg      300

gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat      360

ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc atgattgaac      420

aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact      480

gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc      540

gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg      600

cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg      660

tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt      720

catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc      780

atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag      840

cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg      900

ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc      960

tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt     1020

ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg     1080

ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt     1140

acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct     1200

tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg     1260

agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga     1320

cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccag     1380

cttcaaaagc gctctgaagt tcctatactt tctagagaat aggaacttcg gaataggaac     1440

taaggaggat attcatatgg agggctagcc cgttcctcat tgatttgatt gctaacgtca     1500

tgagcattac tctatcattc cagaatgcct caatgaacaa gttgtttgag aaagagtgtc     1560

gcaatgttgc aaccagagcc cttaaatatg tacgccagaa gaaaactgaa gggcgtctgg     1620

atgaagcatt gtctgtattg attagcctga aacgaattga gcctgatgtt tctcgtctga     1680

tgcgtgaata taagcaaatt atcagattat ttaatgagtc acggaaggat ggcggtagca     1740

ctatcacgtc ttatgaacat ctagactatg cgaaaaaatt actcgttttt gatagcgaaa     1800

atgcctatgc cttgaaatat gccgcattaa atgcaatgca tttacgcgac tacacgcagg     1860

ctttgcagta ttggcagcga ctggagaaag tgaatggacc aacggagccg gtgacaaggc     1920

agatctcgac ctgcataacc gcattacaaa aaaatacatc agggaagtcg taacccggga     1980

ccggtggatc cactctcgag gggcgcgccg gtaccgaatt ctgaagttcc tatactttct     2040

agagaatagg aacttcggaa taggaacttc gagctcgtcg acctaattca tgcccccgaa     2100

ctgcaggagt ggggaggcac gatggccgct ttggtcggtc ttgccttgct cgtcggtgat     2160

gtacttcacc agctccgcga agtcgctctt cttgatggag cgcatgggga cgtgcttggc     2220

aatcacgcgc accccccggc cgttttagcg gctaaaaaag tcatggctct gccctcgggc     2280

ggaccacgcc catcatgacc ttgccaagct cgtcctgctt ctcttcgatc ttcgccagca     2340

gggcgaggat cgtggcatca ccgaaccgcg ccgtgcgcgg gtcgtcggtg agccagagtt     2400

tcagcaggcc gcccaggcgg cccaggtcgc cattgatgcg ggccagctcg cggacgtgct     2460

catagtccac gacgcccgtg attttgtagc cctggccgac ggccagcagg taggccgaca     2520

ggctcatgcc ggccgccgcc gccttttcct caatcgctct tcgttcgtct ggaaggcagt     2580

acaccttgat aggtgggctg cccttcctgg ttggcttggt ttcatcagcc atccgcttgc     2640

cctcatctgt tacgccggcg gtagccggcc agcctcgcag agcaggattc ccgttgagca     2700

ccgccaggtg cgaataaggg acagtgaaga aggaacaccc gctcgcgggt gggcctactt     2760

cacctatcct gcccggctga cgccgttgga tacaccaagg aaagtctaca cgaacccttt     2820

ggcaaaatcc tgtatatcgt gcgaaaaagg atggatatac cgaaaaaatc gctataatga     2880

ccccgaagca gggttatgca gcggaaaacg gccacgatgc gtccggcgta gaggatctga     2940

agatcagcag ttcaacctgt tgatagtacg tactaagctc tcatgtttca cgtactaagc     3000

tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat ggctaacgta     3060

ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc tctcatgttt     3120

gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt aagttttata     3180

agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt gtggacaaca     3240

agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt ttgagtgaca     3300

caggaacact taacggctga catggcggcc gcaaaaatta aaaatgaagt tttaaatcaa     3360

tctaaagtat atatgagtaa acttggtctg acagatcgat ggccccccga tggtagtgtg     3420

gggtctcccc atgcgagagt agggaactgc caggcatcaa ataaaacgaa aggctcagtc     3480

gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg aacgctctcc tgagtaggac     3540

aaatccgccg ggagcggatt tgaacgttgc gaagcaacgg cccggagggt ggcgggcagg     3600

acgcccgcca taaactgcca ggcatcaaat taagcagaag gccatcctga cggatggcct     3660

ttttgcgtgg ccagtgccaa gcttgcatgc                                      3690


<210>  7
<211>  4229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  7
agattgcagc attacacgtc ttgagcgatt gtgtaggctg gagctgcttc aagatcccct       60

cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag      120

ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa      180

gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc      240

tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg      300

gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat      360

ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc atgattgaac      420

aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact      480

gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc      540

gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg      600

cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg      660

tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt      720

catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc      780

atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag      840

cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg      900

ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc      960

tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt     1020

ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg     1080

ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt     1140

acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct     1200

tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg     1260

agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga     1320

cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccag     1380

cttcaaaagc gctctgaagt tcctatactt tctagagaat aggaacttcg gaataggaac     1440

taaggaggat attcatatga aaaaaatcat catattacta acgacatttt tcctgctttc     1500

gggatgcact attcccaggg cggtatttaa atccagcctt attaatcagg acgatcctcg     1560

ttataatctg gtcgaagtca cgccgacatt aaaactaagc gctcccgata ctgtgccgaa     1620

aactattgtc gatccggttt ttgccgcaaa taactggcac tggacatctt tggctaaagg     1680

cgatgtgctg catatcacta ttttatcctc gggcggggct ggatatttat ccaataacgc     1740

gagcggcgac cgtgcggatt ttgaaaatat tcttgtgact gacagtaata ccgttcaggt     1800

gccttatgcc gggacaatcc cggtttctgg attggatgtg acgcaactgg ctgatgagat     1860

caaaaagcga ctttcgcgcg ttgtcctgaa tcctcaggtg attgtgacac ttaccgcccg     1920

caccggagcc atggtgacgg tcgagggcag cgggaaaacg ggtcgatacc ctctcgaaca     1980

gagtatgaat cgtctgagtc atcttttggc aacggcagtg gcagtagaaa ataccagcac     2040

agatatgatg gaagttcacg tgacgcgcca gcagcattat ttcactgcgc gactgtcaga     2100

tatttatcag tatcccggat tggatattgc cttacagccg gatgaccgta tcactctgcg     2160

tcaagtgacc gagtatgtta atgtgctcgg cgcagcaggt gttcagggga aacatgctct     2220

ggttcagcgt cattccagcg tcgtggatgc tttggcgctc gcgaaaggat taaatgacaa     2280

tcttgccgat ccgcaagcga tttttctgta caagcataac gaagcggaac aggcgaaaca     2340

gcagatgcgt aagctgaata tctatcatgt cgatatgagc caacctaact cggtgttttt     2400

agcgcaggcc atacgagtgg acaacggcga tgttatctat atctcgaacg cctctttgac     2460

tgatttcgct aaggtgaaag ccgcattcga tagctttttg acccgcggca ctaattcttt     2520

ctaaggatcc actctcgagg ggcgcgccgg taccgaattc tgaagttcct atactttcta     2580

gagaatagga acttcggaat aggaacttcg agctcgtcga cctaattcat gcccccgaac     2640

tgcaggagtg gggaggcacg atggccgctt tggtcggtct tgccttgctc gtcggtgatg     2700

tacttcacca gctccgcgaa gtcgctcttc ttgatggagc gcatggggac gtgcttggca     2760

atcacgcgca ccccccggcc gttttagcgg ctaaaaaagt catggctctg ccctcgggcg     2820

gaccacgccc atcatgacct tgccaagctc gtcctgcttc tcttcgatct tcgccagcag     2880

ggcgaggatc gtggcatcac cgaaccgcgc cgtgcgcggg tcgtcggtga gccagagttt     2940

cagcaggccg cccaggcggc ccaggtcgcc attgatgcgg gccagctcgc ggacgtgctc     3000

atagtccacg acgcccgtga ttttgtagcc ctggccgacg gccagcaggt aggccgacag     3060

gctcatgccg gccgccgccg ccttttcctc aatcgctctt cgttcgtctg gaaggcagta     3120

caccttgata ggtgggctgc ccttcctggt tggcttggtt tcatcagcca tccgcttgcc     3180

ctcatctgtt acgccggcgg tagccggcca gcctcgcaga gcaggattcc cgttgagcac     3240

cgccaggtgc gaataaggga cagtgaagaa ggaacacccg ctcgcgggtg ggcctacttc     3300

acctatcctg cccggctgac gccgttggat acaccaagga aagtctacac gaaccctttg     3360

gcaaaatcct gtatatcgtg cgaaaaagga tggatatacc gaaaaaatcg ctataatgac     3420

cccgaagcag ggttatgcag cggaaaacgg ccacgatgcg tccggcgtag aggatctgaa     3480

gatcagcagt tcaacctgtt gatagtacgt actaagctct catgtttcac gtactaagct     3540

ctcatgttta acgtactaag ctctcatgtt taacgaacta aaccctcatg gctaacgtac     3600

taagctctca tggctaacgt actaagctct catgtttcac gtactaagct ctcatgtttg     3660

aacaataaaa ttaatataaa tcagcaactt aaatagcctc taaggtttta agttttataa     3720

gaaaaaaaag aatatataag gcttttaaag cttttaaggt ttaacggttg tggacaacaa     3780

gccagggatg taacgcactg agaagccctt agagcctctc aaagcaattt tgagtgacac     3840

aggaacactt aacggctgac atggcggccg caaaaattaa aaatgaagtt ttaaatcaat     3900

ctaaagtata tatgagtaaa cttggtctga cagatcgatg gccccccgat ggtagtgtgg     3960

ggtctcccca tgcgagagta gggaactgcc aggcatcaaa taaaacgaaa ggctcagtcg     4020

aaagactggg cctttcgttt tatctgttgt ttgtcggtga acgctctcct gagtaggaca     4080

aatccgccgg gagcggattt gaacgttgcg aagcaacggc ccggagggtg gcgggcagga     4140

cgcccgccat aaactgccag gcatcaaatt aagcagaagg ccatcctgac ggatggcctt     4200

tttgcgtggc cagtgccaag cttgcatgc                                       4229


<210>  8
<211>  9376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  8
agattgcagc attacacgtc ttgagcgatt gtgtaggctg gagctgcttc aagatcccct       60

cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag      120

ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa      180

gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc      240

tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg      300

gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat      360

ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc atgattgaac      420

aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact      480

gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc      540

gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg      600

cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg      660

tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt      720

catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc      780

atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag      840

cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg      900

ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc      960

tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt     1020

ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg     1080

ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt     1140

acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct     1200

tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg     1260

agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga     1320

cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccag     1380

cttcaaaagc gctctgaagt tcctatactt tctagagaat aggaacttcg gaataggaac     1440

taaggaggat attcatatgg agggctagcc cgttcctcat tgatttgatt gctaacgtca     1500

tgagcattac tctatcattc cagaatgcct caatgaacaa gttgtttgag aaagagtgtc     1560

gcaatgttgc aaccagagcc cttaaatatg tacgccagaa gaaaactgaa gggcgtctgg     1620

atgaagcatt gtctgtattg attagcctga aacgaattga gcctgatgtt tctcgtctga     1680

tgcgtgaata taagcaaatt atcagattat ttaatgagtc acggaaggat ggcggtagca     1740

ctatcacgtc ttatgaacat ctagactatg cgaaaaaatt actcgttttt gatagcgaaa     1800

atgcctatgc cttgaaatat gccgcattaa atgcaatgca tttacgcgac tacacgcagg     1860

ctttgcagta ttggcagcga ctggagaaag tgaatggacc aacggagccg gtgacaaggc     1920

agatctcgac ctgcataacc gcattacaaa aaaatacatc agggaagtcg taacccggga     1980

ccggtggatc cactctcgag gccggaggat ctgccgtcaa ttgtctgatt cgttaccaat     2040

tatgacaact tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc     2100

gggctggccc cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca     2160

acattgcgac cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg     2220

ctgatacgtt ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga     2280

tgtgacagac gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg     2340

ctgtctgcca ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt     2400

ggatggagcg actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt     2460

atcgccagca gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac     2520

aggtcgctga aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat     2580

attgacggcc agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg     2640

tgataccatt cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac     2700

agcaaaatat cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga     2760

ccgcgaatgg tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa     2820

tcgagataac cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag     2880

tatcccggca gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc     2940

agagaagaaa ccaattgtcc atattgcatc agacattgcc gtcactgcgt cttttactgg     3000

ctcttctcgc taaccaaacc ggtaaccccg cttattaaaa gcattctgta acaaagcggg     3060

accaaagcca tgacaaaaac gcgtaacaaa agtgtctata atcacggcag aaaagtccac     3120

attgattatt tgcacggcgt cacactttgc tatgccatag catttttatc cataagatta     3180

gcggatccta cctgacgctt tttatcgcaa ctctctactg tttctccata cccgtttttt     3240

tggatggagt gaaacgatgg accagaagct gttaacggat ttccgctcag aactactcga     3300

ttcacgtttt ggcgcaaagg ccatttctac tatcgcggag tcaaaacgat ttccgctgca     3360

cgaaatgcgc gatgatgtcg cattccagat tatcaatgat gaattatatc ttgatggcaa     3420

cgctcgtcag aacctagcca ctttctgcca gacctgggac gacgaaaacg tccataaatt     3480

gatggatttg tcgatcaata aaaactggat cgacaaagaa gaatatccgc aatccgcagc     3540

catcgacctg cgttgcgtaa atatggttgc cgatctgtgg catgcgcctg cgccgaaaaa     3600

tggtcaggcc gttggcacca acaccattgg ttcttccgag gcctgtatgc tcggcgggat     3660

ggcgatgaaa tggcgttggc gcaagcgtat ggaagctgca ggcaaaccaa cggataaacc     3720

aaacctagtg tgcggtccgg tacaaatctg ctggcataaa ttcgcccgct actgggatgt     3780

ggagctgcgt gagatcccta tgcgccccgg tcagttgttt atggacccga aacgcatgat     3840

tgaagcctgt gacgaaaaca ccatcggcgt ggtgccgact ttcggcgtga cctacaccgg     3900

taactatgag ttcccacaac cgctgcacga tgcgctggat aaattccagg ccgacaccgg     3960

tatcgacatc gacatgcaca tcgacgctgc cagcggtggc ttcctggcac cgttcgtcgc     4020

cccggatatc gtctgggact tccgcctgcc gcgtgtgaaa tcgatcagtg cttcaggcca     4080

taaattcggt ctggctccgc tgggctgcgg ctgggttatc tggcgtgacg aagaagcgct     4140

gccgcaggaa ctggtgttca acgttgacta cctgggtggt caaattggta cttttgccat     4200

caacttctcc cgcccggcgg gtcaggtaat tgcacagtac tatgaattcc tgcgcctcgg     4260

tcgtgaaggc tataccaaag tacagaacgc ctcttaccag gttgccgctt atctggcgga     4320

tgaaatcgcc aaacaggggc cgtatgagtt catctgtacg ggtcgcccgg acgaaggcat     4380

cccggcggtt tgcttcaaac tgaaagatgg tgaagatccg ggatacaccc tgtacgacct     4440

ctctgaacgt ctgcgtctgc gcggctggca ggttccggcc ttcactctcg gcggtgaagc     4500

caccgacatc gtggtgatgc gcattatgtg tcgtcgcggc ttcgaaatgg actttgctga     4560

actgttgctg gaagactaca aagcctccct gaaatatctc agcgatcacc cgaaactgca     4620

gggtattgcc cagcagaaca gctttaaaca cacctgacct acttggagtg ttttaatgcg     4680

atccaatcat tttaaggagt ttaaaatgga taagaagcaa gtaacggatt taaggtcgga     4740

actactcgat tcacgttttg gtgcgaagtc tatttccact atcgcagaat caaaacgttt     4800

tccgctgcac gaaatgcgcg acgatgtcgc atttcagatt atcaatgatg aattatatct     4860

tgatggcaac gctcgtcaga acctggccac tttctgccag acctgggacg acgaaaacgt     4920

ccacaagttg atggatttat ccattaacaa aaactggatc gacaaagaag aatatccgca     4980

atccgcagcc atcgacctgc gttgcgtaaa catggttgcc gatctgtggc atgcgcctgc     5040

gccgaaaaat ggtcaggccg ttggcaccaa caccattggt tcttccgagg cctgtatgct     5100

cggcgggatg gcgatgaaat ggcgttggcg caagcgtatg gaagctgcag gcaaaccaac     5160

ggataaacca aacctggtgt gcggtccggt gcaaatctgc tggcataaat tcgcccgcta     5220

ctgggatgtg gagctgcgtg agatccctat gcgccccggt cagttgttta tggacccgaa     5280

acgcatgatt gaagcctgcg acgaaaatac catcggcgtg gtgccgactt tcggcgtgac     5340

ctacaccggt aactatgagt tcccgcaacc gctgcacgat gcactggata aattccaggc     5400

cgacaccggt atcgacatcg acatgcacat cgacgccgcc agcggtggct ttctggcacc     5460

gttcgtcgcc ccggatatcg tctgggactt ccgcctgccg cgtgtgaaat cgatcagtgc     5520

ttcaggccat aaattcggtc tggctccgct gggctgcggc tgggttatct ggcgtgacga     5580

agaagcgctg ccgcaggaac tggtgttcaa cgttgactac ctcggtggtc agattggtac     5640

ttttgccatc aacttctccc gcccggcggg tcaggtgatt gcacagtact atgaattcct     5700

gcgccttggt cgtgaaggct ataccaaagt acagaatgct tcctaccagg tcgctgccta     5760

tctggcggat gagatcgcca aactggggcc gtatgagttc atctgtaccg gtcgcccgga     5820

cgaaggcatc ccggcggttt gcttcaaact gaaagatggt gaagatccgg gatacaccct     5880

gtacgacctc tctgaacgtc tgcgtctgcg cggctggcag gttccggcct tcactctcgg     5940

cggtgaagcc accgacatcg tggtgatgcg cattatgtgt cgtcgcggct tcgaaatgga     6000

ctttgctgaa ctgttgctgg aagactacaa agcctccctg aaatatctca gcgatcaccc     6060

gaaactgcag ggtattgccc agcagaacag ctttaaacat acctgataac cgttttggag     6120

tgataatatg gctacatcag tacagacagg taaagctaag cagctcacat tactcggatt     6180

ctttgccata acggcatcga tggtaatggc tgtttatgaa taccctacct tcgcaacatc     6240

gggcttttca ttagtcttct tcctgctatt aggcgggatt ttatggttta ttcccgtggg     6300

actttgtgct gcggaaatgg ccaccgtcga cggctgggaa gaaggtggtg tcttcgcctg     6360

ggtatcaaat actctgggtc cgagatgggg atttgcagcg atctcatttg gctatctgca     6420

aatcgccatt ggttttattc cgatgctcta tttcgtgtta ggggcactct cctacatcct     6480

gaaatggcca gcgctgaatg aagaccccat taccaaaact attgcagcac tcatcattct     6540

ttgggcgctg gcattaacgc agtttggtgg cacgaaatac acggcgcgaa ttgctaaagt     6600

tggcttcttc gccggtatcc tgttacctgc atttattttg atcgcattag cggctattta     6660

cctgcactcc ggtgcccccg ttgctatcga aatggattcg aagaccttct tccctgactt     6720

ctctaaagtg ggcacactgg ttgtatttgt tgccttcatt ttgagttata tgggcgtaga     6780

agcttccgca actcacgtca atgaaatgag caaccccggg cgcgactatc cactggctat     6840

gttactgctg atggtggcgg caatctgctt aagctctgtt ggcggtttgt ctattgcgat     6900

ggtcattccg ggtaatgaaa tcaacctctc cgcaggggta atgcaaacct ttaccgttct     6960

gatgtcccat gtggcaccgg aaattgagtg gacggttcgc gtgatctccg cactgctgtt     7020

gctgggtgtt ctggcggaaa tcgcctcctg gattgttggt ccttctcgcg ggatgtatgt     7080

cacagcgcag aaaaacctgc tgccagcggc attcgctaaa atgaacaaaa atggcgtacc     7140

ggtaacgctg gtcatttcgc agctggtgat tacttctatc gcgttgatca tcctcaccaa     7200

taccggtggc ggtaacaaca tgtccttcct gatcgcactg gcgctgacgg tggtgattta     7260

tctgtgtgct tatttcatgc tgtttattgg ctacattgtg ttggttctta aacatcctga     7320

cttaaaacgc acatttaata tccctggtgg taaaggggtg aaactggtcg tggcaattgt     7380

cggtctgctg acttcaatta tggcgtttat tgtttccttc ctgccgccgg ataacatcca     7440

gggtgattct accgatatgt atgttgaatt actggttgtt agtttcctgg tggtacttgc     7500

cctgcccttt attctctatg ctgttcatga tcgtaaaggc aaagcgaata ccggcgtcac     7560

tctggagcca atcaacagtc agaacgcacc aaaaggtcac ttcttcctgc acccgcgtgc     7620

acgttcacca cactatattg tgatgaatga caagaaacac taatctagag tcgacctgca     7680

ggcatgcaag cttggggtac cgaattctga agttcctata ctttctagag aataggaact     7740

tcggaatagg aacttcgagc tcgtcgacct aattcatgcc cccgaactgc aggagtgggg     7800

aggcacgatg gccgctttgg tcggtcttgc cttgctcgtc ggtgatgtac ttcaccagct     7860

ccgcgaagtc gctcttcttg atggagcgca tggggacgtg cttggcaatc acgcgcaccc     7920

cccggccgtt ttagcggcta aaaaagtcat ggctctgccc tcgggcggac cacgcccatc     7980

atgaccttgc caagctcgtc ctgcttctct tcgatcttcg ccagcagggc gaggatcgtg     8040

gcatcaccga accgcgccgt gcgcgggtcg tcggtgagcc agagtttcag caggccgccc     8100

aggcggccca ggtcgccatt gatgcgggcc agctcgcgga cgtgctcata gtccacgacg     8160

cccgtgattt tgtagccctg gccgacggcc agcaggtagg ccgacaggct catgccggcc     8220

gccgccgcct tttcctcaat cgctcttcgt tcgtctggaa ggcagtacac cttgataggt     8280

gggctgccct tcctggttgg cttggtttca tcagccatcc gcttgccctc atctgttacg     8340

ccggcggtag ccggccagcc tcgcagagca ggattcccgt tgagcaccgc caggtgcgaa     8400

taagggacag tgaagaagga acacccgctc gcgggtgggc ctacttcacc tatcctgccc     8460

ggctgacgcc gttggataca ccaaggaaag tctacacgaa ccctttggca aaatcctgta     8520

tatcgtgcga aaaaggatgg atataccgaa aaaatcgcta taatgacccc gaagcagggt     8580

tatgcagcgg aaaacggcca cgatgcgtcc ggcgtagagg atctgaagat cagcagttca     8640

acctgttgat agtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg     8700

tactaagctc tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg     8760

ctaacgtact aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta     8820

atataaatca gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat     8880

atataaggct tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa     8940

cgcactgaga agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac     9000

ggctgacatg gcggccgcaa aaattaaaaa tgaagtttta aatcaatcta aagtatatat     9060

gagtaaactt ggtctgacag atcgatggcc ccccgatggt agtgtggggt ctccccatgc     9120

gagagtaggg aactgccagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct     9180

ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag taggacaaat ccgccgggag     9240

cggatttgaa cgttgcgaag caacggcccg gagggtggcg ggcaggacgc ccgccataaa     9300

ctgccaggca tcaaattaag cagaaggcca tcctgacgga tggccttttt gcgtggccag     9360

tgccaagctt gcatgc                                                     9376


<210>  9
<211>  8173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  9
agattgcagc attacacgtc ttgagcgatt gtgtaggctg gagctgcttc aagatcccct       60

cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag      120

ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa      180

gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc      240

tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg      300

gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat      360

ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc atgattgaac      420

aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact      480

gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc      540

gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg      600

cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg      660

tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt      720

catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc      780

atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag      840

cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg      900

ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc      960

tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt     1020

ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg     1080

ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt     1140

acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct     1200

tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg     1260

agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga     1320

cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccag     1380

cttcaaaagc gctctgaagt tcctatactt tctagagaat aggaacttcg gaataggaac     1440

taaggaggat attcatatgg agggctagcc cgttcctcat tgatttgatt gctaacgtca     1500

tgagcattac tctatcattc cagaatgcct caatgaacaa gttgtttgag aaagagtgtc     1560

gcaatgttgc aaccagagcc cttaaatatg tacgccagaa gaaaactgaa gggcgtctgg     1620

atgaagcatt gtctgtattg attagcctga aacgaattga gcctgatgtt tctcgtctga     1680

tgcgtgaata taagcaaatt atcagattat ttaatgagtc acggaaggat ggcggtagca     1740

ctatcacgtc ttatgaacat ctagactatg cgaaaaaatt actcgttttt gatagcgaaa     1800

atgcctatgc cttgaaatat gccgcattaa atgcaatgca tttacgcgac tacacgcagg     1860

ctttgcagta ttggcagcga ctggagaaag tgaatggacc aacggagccg gtgacaaggc     1920

agatctcgac ctgcataacc gcattacaaa aaaatacatc agggaagtcg taacccggga     1980

ccggtggatc cagcttaata ttgacaacat aaaaaacttt gtgttatact tgtaacgcta     2040

caaggagagg acatatggac cagaagctgt taacggattt ccgctcagaa ctactcgatt     2100

cacgttttgg cgcaaaggcc atttctacta tcgcggagtc aaaacgattt ccgctgcacg     2160

aaatgcgcga tgatgtcgca ttccagatca ttaacgatga actgtatctg gatggcaacg     2220

cccgtcagaa cctagcgact ttttgccaga cctgggatga tgaaaacgtc cataaattga     2280

tggatttgtc gatcaataaa aactggattg acaaagaaga atatccgcag tctgcggcga     2340

ttgatctgcg ttgcgtaaat atggttgcgg atctgtggca tgcgcctgcg ccgaaaaacg     2400

gccaggcggt gggcaccaac accatcggct cttctgaagc gtgcatgctg ggcggcatgg     2460

cgatgaaatg gcgttggcgt aaacgtatgg aagcggcggg caaaccaacg gataaaccaa     2520

acctagtgtg cggtccggta cagatctgct ggcataaatt tgcgcgttac tgggatgtgg     2580

aactgcgtga aattccgatg cgtcccggcc agctgtttat ggacccgaaa cgtatgatcg     2640

aagcctgtga cgaaaacacc atcggcgtgg tgccgacttt tggcgtgacc tacaccggca     2700

actatgagtt tccacaaccg ctgcacgatg cgctggataa atttcaggcg gacaccggta     2760

tcgacattga catgcacatc gacgctgcga gcggcggctt cctggcgccg ttcgtggcgc     2820

cggatattgt gtgggatttt cgtctgccgc gtgtgaaatc tattagcgcg tctggccata     2880

aatttggtct ggcgccgctg ggctgcggct gggtgatttg gcgtgatgaa gaagcgctgc     2940

cgcaggaact ggtgtttaac gtggactacc tgggtggtca aatcggtact tttgccatta     3000

acttctctcg cccggcgggt caggtaattg cgcagtacta tgaattcctg cgcctcggcc     3060

gtgaaggcta taccaaagtg cagaacgcct cttaccaggt tgccgcttat ctggcggatg     3120

aaatcgcgaa acaggggccg tatgaattca tctgtacggg tcgcccggat gaaggcattc     3180

cggcggtgtg cttcaaactg aaagatggcg aagatccggg ctacaccctg tacgacctgt     3240

ctgaacgtct gcgtctgcgt ggctggcagg tgccggcgtt caccctgggc ggcgaagcga     3300

ccgatattgt ggtgatgcgt attatgtgcc gtcgtggctt tgaaatggat tttgcggaac     3360

tgctgctgga agattataaa gcgagcctga aatatctgag cgatcatccg aaactgcagg     3420

gcatcgcgca gcagaacagc tttaaacata cctgactcga gggagtgttt taatgcgatc     3480

caatcatttt aaggagttta aaatggataa gaagcaagta acggatttaa ggtcggaact     3540

actcgattca cgttttggtg cgaagtctat ttccactatc gcagaatcaa aacgttttcc     3600

gctgcacgaa atgcgcgacg atgtcgcatt tcagattatc aatgatgaat tatatcttga     3660

tggcaacgct cgtcagaacc tggccacttt ctgccagacc tgggacgacg aaaacgtcca     3720

caagttgatg gatttatcca ttaacaaaaa ctggatcgac aaagaagaat atccgcaatc     3780

cgcagccatc gacctgcgtt gcgtaaacat ggttgccgat ctgtggcatg cgcctgcgcc     3840

gaaaaatggt caggccgttg gcaccaacac cattggttct tccgaggcct gtatgctcgg     3900

cgggatggcg atgaaatggc gttggcgcaa gcgtatggaa gctgcaggca aaccaacgga     3960

taaaccaaac ctggtgtgcg gtccggtgca aatctgctgg cataaattcg cccgctactg     4020

ggatgtggag ctgcgtgaga tccctatgcg ccccggtcag ttgtttatgg acccgaaacg     4080

catgattgaa gcctgcgacg aaaataccat cggcgtggtg ccgactttcg gcgtgaccta     4140

caccggtaac tatgagttcc cgcaaccgct gcacgatgca ctggataaat tccaggccga     4200

caccggtatc gacatcgaca tgcacatcga cgccgccagc ggtggctttc tggcaccgtt     4260

cgtcgccccg gatatcgtct gggacttccg cctgccgcgt gtgaaatcga tcagtgcttc     4320

aggccataaa ttcggtctgg ctccgctggg ctgcggctgg gttatctggc gtgacgaaga     4380

agcgctgccg caggaactgg tgttcaacgt tgactacctc ggtggtcaga ttggtacttt     4440

tgccatcaac ttctcccgcc cggcgggtca ggtgattgca cagtactatg aattcctgcg     4500

ccttggtcgt gaaggctata ccaaagtaca gaatgcttcc taccaggtcg ctgcctatct     4560

ggcggatgag atcgccaaac tggggccgta tgagttcatc tgtaccggtc gcccggacga     4620

aggcatcccg gcggtttgct tcaaactgaa agatggtgaa gatccgggat acaccctgta     4680

cgacctctct gaacgtctgc gtctgcgcgg ctggcaggtt ccggccttca ctctcggcgg     4740

tgaagccacc gacatcgtgg tgatgcgcat tatgtgtcgt cgcggcttcg aaatggactt     4800

tgctgaactg ttgctggaag actacaaagc ctccctgaaa tatctcagcg atcacccgaa     4860

actgcagggt attgcccagc agaacagctt taaacatacc tgataaccgt tttggagtga     4920

taatatggct acatcagtac agacaggtaa agctaagcag ctcacattac tcggattctt     4980

tgccataacg gcatcgatgg taatggctgt ttatgaatac cctaccttcg caacatcggg     5040

cttttcatta gtcttcttcc tgctattagg cgggatttta tggtttattc ccgtgggact     5100

ttgtgctgcg gaaatggcca ccgtcgacgg ctgggaagaa ggtggtgtct tcgcctgggt     5160

atcaaatact ctgggtccga gatggggatt tgcagcgatc tcatttggct atctgcaaat     5220

cgccattggt tttattccga tgctctattt cgtgttaggg gcactctcct acatcctgaa     5280

atggccagcg ctgaatgaag accccattac caaaactatt gcagcactca tcattctttg     5340

ggcgctggca ttaacgcagt ttggtggcac gaaatacacg gcgcgaattg ctaaagttgg     5400

cttcttcgcc ggtatcctgt tacctgcatt tattttgatc gcattagcgg ctatttacct     5460

gcactccggt gcccccgttg ctatcgaaat ggattcgaag accttcttcc ctgacttctc     5520

taaagtgggc acactggttg tatttgttgc cttcattttg agttatatgg gcgtagaagc     5580

ttccgcaact cacgtcaatg aaatgagcaa ccccgggcgc gactatccac tggctatgtt     5640

actgctgatg gtggcggcaa tctgcttaag ctctgttggc ggtttgtcta ttgcgatggt     5700

cattccgggt aatgaaatca acctctccgc aggggtaatg caaaccttta ccgttctgat     5760

gtcccatgtg gcaccggaaa ttgagtggac ggttcgcgtg atctccgcac tgctgttgct     5820

gggtgttctg gcggaaatcg cctcctggat tgttggtcct tctcgcggga tgtatgtcac     5880

agcgcagaaa aacctgctgc cagcggcatt cgctaaaatg aacaaaaatg gcgtaccggt     5940

aacgctggtc atttcgcagc tggtgattac ttctatcgcg ttgatcatcc tcaccaatac     6000

cggtggcggt aacaacatgt ccttcctgat cgcactggcg ctgacggtgg tgatttatct     6060

gtgtgcttat ttcatgctgt ttattggcta cattgtgttg gttcttaaac atcctgactt     6120

aaaacgcaca tttaatatcc ctggtggtaa aggggtgaaa ctggtcgtgg caattgtcgg     6180

tctgctgact tcaattatgg cgtttattgt ttccttcctg ccgccggata acatccaggg     6240

tgattctacc gatatgtatg ttgaattact ggttgttagt ttcctggtgg tacttgccct     6300

gccctttatt ctctatgctg ttcatgatcg taaaggcaaa gcgaataccg gcgtcactct     6360

ggagccaatc aacagtcaga acgcaccaaa aggtcacttc ttcctgcacc cgcgtgcacg     6420

ttcaccacac tatattgtga tgaatgacaa gaaacactaa tctagagtcg acctgcaggc     6480

atgcaagctt ggggtaccga attctgaagt tcctatactt tctagagaat aggaacttcg     6540

gaataggaac ttcgagctcg tcgacctaat tcatgccccc gaactgcagg agtggggagg     6600

cacgatggcc gctttggtcg gtcttgcctt gctcgtcggt gatgtacttc accagctccg     6660

cgaagtcgct cttcttgatg gagcgcatgg ggacgtgctt ggcaatcacg cgcacccccc     6720

ggccgtttta gcggctaaaa aagtcatggc tctgccctcg ggcggaccac gcccatcatg     6780

accttgccaa gctcgtcctg cttctcttcg atcttcgcca gcagggcgag gatcgtggca     6840

tcaccgaacc gcgccgtgcg cgggtcgtcg gtgagccaga gtttcagcag gccgcccagg     6900

cggcccaggt cgccattgat gcgggccagc tcgcggacgt gctcatagtc cacgacgccc     6960

gtgattttgt agccctggcc gacggccagc aggtaggccg acaggctcat gccggccgcc     7020

gccgcctttt cctcaatcgc tcttcgttcg tctggaaggc agtacacctt gataggtggg     7080

ctgcccttcc tggttggctt ggtttcatca gccatccgct tgccctcatc tgttacgccg     7140

gcggtagccg gccagcctcg cagagcagga ttcccgttga gcaccgccag gtgcgaataa     7200

gggacagtga agaaggaaca cccgctcgcg ggtgggccta cttcacctat cctgcccggc     7260

tgacgccgtt ggatacacca aggaaagtct acacgaaccc tttggcaaaa tcctgtatat     7320

cgtgcgaaaa aggatggata taccgaaaaa atcgctataa tgaccccgaa gcagggttat     7380

gcagcggaaa acggccacga tgcgtccggc gtagaggatc tgaagatcag cagttcaacc     7440

tgttgatagt acgtactaag ctctcatgtt tcacgtacta agctctcatg tttaacgtac     7500

taagctctca tgtttaacga actaaaccct catggctaac gtactaagct ctcatggcta     7560

acgtactaag ctctcatgtt tcacgtacta agctctcatg tttgaacaat aaaattaata     7620

taaatcagca acttaaatag cctctaaggt tttaagtttt ataagaaaaa aaagaatata     7680

taaggctttt aaagctttta aggtttaacg gttgtggaca acaagccagg gatgtaacgc     7740

actgagaagc ccttagagcc tctcaaagca attttgagtg acacaggaac acttaacggc     7800

tgacatggcg gccgcaaaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     7860

taaacttggt ctgacagatc gatggccccc cgatggtagt gtggggtctc cccatgcgag     7920

agtagggaac tgccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc     7980

gttttatctg ttgtttgtcg gtgaacgctc tcctgagtag gacaaatccg ccgggagcgg     8040

atttgaacgt tgcgaagcaa cggcccggag ggtggcgggc aggacgcccg ccataaactg     8100

ccaggcatca aattaagcag aaggccatcc tgacggatgg cctttttgcg tggccagtgc     8160

caagcttgca tgc                                                        8173


<210>  10
<211>  7140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid constructs

<400>  10
cacgcaatat ttcaatgatg gcaacgcatt ctctgaagct ttccatgccg gcattcaatc       60

gcagcgccta aatgatacgt ttatggaaac ggcgttatct ttggcaatca aattcagtga      120

tgaattgatt ttcatgcatg cgctcgagca gctactccgc catgagtcag aatttgcgct      180

gacggtattg tcgacgattc atgataccgg tctcgttatc cgcacagctt tctgcatcaa      240

gaatatgagc tatcatcaag cgcttcgcac ctcgtataaa gataaaatcc acgacgtttt      300

tgaggcatgg aacaataccg cgctgtcgct acattcggtt gatgattttg tctcactgag      360

tacttcgcta gcctatagct actctgcatt tatggtttat ccccattcac gtatttctcg      420

ctttaataat gaagttaaaa tggcatggcg cgataaatta agagaaatgt atgagcgtga      480

ggattatgaa aatatcctgg caggggcgaa aatagtgtgg ccacttctga agtttgatcc      540

cgttggcacc gtatattgtg caagaacgct ggtgaatctt ggtgcctgga aagacgcgtg      600

cacgttggcc cacatgacct tgattcgtaa ctcgaacatt accagcctgc agtcgattat      660

gttacgcagc atacgtcata ttaacaacat tccgttcctc attgatttga ttgctaacgt      720

catgagcatt actctatcat tccagaatgc ctcaatgaac aagttgtttg agaaagagtg      780

tcgcaatgtt gcaaccagag cccttaaata tgtacgccag aagaaaactg aagggcgtct      840

ggatgaagca ttgtctgtat tgattagcct gaaacgaatt gagcctgatg tttctcgtct      900

gatgcgtgaa tataagcaaa ttatcagatt atttaatgag tcacggaagg atggcggtag      960

cactatcacg tcttatgaac atctagacta tgcgaaaaaa ttactcgttt ttgatagcga     1020

aaatgcctat gccttgaaat atgccgcatt aaatgcaatg catttacgcg actacacgca     1080

ggctttgcag tattggcagc gactggagaa agtgaatgga ccaacggagc cggtgacaag     1140

gcagatctcg acctgcataa ccgcattaca aaaaaataca tcagggaagt cgtaacccgg     1200

gaccggtgga tccagcttaa tattgacaac ataaaaaact ttgtgttata cttgtaacgc     1260

tacaaggaga ggacatatgg accagaagct gttaacggat ttccgctcag aactactcga     1320

ttcacgtttt ggcgcaaagg ccatttctac tatcgcggag tcaaaacgat ttccgctgca     1380

cgaaatgcgc gatgatgtcg cattccagat cattaacgat gaactgtatc tggatggcaa     1440

cgcccgtcag aacctagcga ctttttgcca gacctgggat gatgaaaacg tccataaatt     1500

gatggatttg tcgatcaata aaaactggat tgacaaagaa gaatatccgc agtctgcggc     1560

gattgatctg cgttgcgtaa atatggttgc ggatctgtgg catgcgcctg cgccgaaaaa     1620

cggccaggcg gtgggcacca acaccatcgg ctcttctgaa gcgtgcatgc tgggcggcat     1680

ggcgatgaaa tggcgttggc gtaaacgtat ggaagcggcg ggcaaaccaa cggataaacc     1740

aaacctagtg tgcggtccgg tacagatctg ctggcataaa tttgcgcgtt actgggatgt     1800

ggaactgcgt gaaattccga tgcgtcccgg ccagctgttt atggacccga aacgtatgat     1860

cgaagcctgt gacgaaaaca ccatcggcgt ggtgccgact tttggcgtga cctacaccgg     1920

caactatgag tttccacaac cgctgcacga tgcgctggat aaatttcagg cggacaccgg     1980

tatcgacatt gacatgcaca tcgacgctgc gagcggcggc ttcctggcgc cgttcgtggc     2040

gccggatatt gtgtgggatt ttcgtctgcc gcgtgtgaaa tctattagcg cgtctggcca     2100

taaatttggt ctggcgccgc tgggctgcgg ctgggtgatt tggcgtgatg aagaagcgct     2160

gccgcaggaa ctggtgttta acgtggacta cctgggtggt caaatcggta cttttgccat     2220

taacttctct cgcccggcgg gtcaggtaat tgcgcagtac tatgaattcc tgcgcctcgg     2280

ccgtgaaggc tataccaaag tgcagaacgc ctcttaccag gttgccgctt atctggcgga     2340

tgaaatcgcg aaacaggggc cgtatgaatt catctgtacg ggtcgcccgg atgaaggcat     2400

tccggcggtg tgcttcaaac tgaaagatgg cgaagatccg ggctacaccc tgtacgacct     2460

gtctgaacgt ctgcgtctgc gtggctggca ggtgccggcg ttcaccctgg gcggcgaagc     2520

gaccgatatt gtggtgatgc gtattatgtg ccgtcgtggc tttgaaatgg attttgcgga     2580

actgctgctg gaagattata aagcgagcct gaaatatctg agcgatcatc cgaaactgca     2640

gggcatcgcg cagcagaaca gctttaaaca tacctgactc gagggagtgt tttaatgcga     2700

tccaatcatt ttaaggagtt taaaatggat aagaagcaag taacggattt aaggtcggaa     2760

ctactcgatt cacgttttgg tgcgaagtct atttccacta tcgcagaatc aaaacgtttt     2820

ccgctgcacg aaatgcgcga cgatgtcgca tttcagatta tcaatgatga attatatctt     2880

gatggcaacg ctcgtcagaa cctggccact ttctgccaga cctgggacga cgaaaacgtc     2940

cacaagttga tggatttatc cattaacaaa aactggatcg acaaagaaga atatccgcaa     3000

tccgcagcca tcgacctgcg ttgcgtaaac atggttgccg atctgtggca tgcgcctgcg     3060

ccgaaaaatg gtcaggccgt tggcaccaac accattggtt cttccgaggc ctgtatgctc     3120

ggcgggatgg cgatgaaatg gcgttggcgc aagcgtatgg aagctgcagg caaaccaacg     3180

gataaaccaa acctggtgtg cggtccggtg caaatctgct ggcataaatt cgcccgctac     3240

tgggatgtgg agctgcgtga gatccctatg cgccccggtc agttgtttat ggacccgaaa     3300

cgcatgattg aagcctgcga cgaaaatacc atcggcgtgg tgccgacttt cggcgtgacc     3360

tacaccggta actatgagtt cccgcaaccg ctgcacgatg cactggataa attccaggcc     3420

gacaccggta tcgacatcga catgcacatc gacgccgcca gcggtggctt tctggcaccg     3480

ttcgtcgccc cggatatcgt ctgggacttc cgcctgccgc gtgtgaaatc gatcagtgct     3540

tcaggccata aattcggtct ggctccgctg ggctgcggct gggttatctg gcgtgacgaa     3600

gaagcgctgc cgcaggaact ggtgttcaac gttgactacc tcggtggtca gattggtact     3660

tttgccatca acttctcccg cccggcgggt caggtgattg cacagtacta tgaattcctg     3720

cgccttggtc gtgaaggcta taccaaagta cagaatgctt cctaccaggt cgctgcctat     3780

ctggcggatg agatcgccaa actggggccg tatgagttca tctgtaccgg tcgcccggac     3840

gaaggcatcc cggcggtttg cttcaaactg aaagatggtg aagatccggg atacaccctg     3900

tacgacctct ctgaacgtct gcgtctgcgc ggctggcagg ttccggcctt cactctcggc     3960

ggtgaagcca ccgacatcgt ggtgatgcgc attatgtgtc gtcgcggctt cgaaatggac     4020

tttgctgaac tgttgctgga agactacaaa gcctccctga aatatctcag cgatcacccg     4080

aaactgcagg gtattgccca gcagaacagc tttaaacata cctgataacc gttttggagt     4140

gataatatgg ctacatcagt acagacaggt aaagctaagc agctcacatt actcggattc     4200

tttgccataa cggcatcgat ggtaatggct gtttatgaat accctacctt cgcaacatcg     4260

ggcttttcat tagtcttctt cctgctatta ggcgggattt tatggtttat tcccgtggga     4320

ctttgtgctg cggaaatggc caccgtcgac ggctgggaag aaggtggtgt cttcgcctgg     4380

gtatcaaata ctctgggtcc gagatgggga tttgcagcga tctcatttgg ctatctgcaa     4440

atcgccattg gttttattcc gatgctctat ttcgtgttag gggcactctc ctacatcctg     4500

aaatggccag cgctgaatga agaccccatt accaaaacta ttgcagcact catcattctt     4560

tgggcgctgg cattaacgca gtttggtggc acgaaataca cggcgcgaat tgctaaagtt     4620

ggcttcttcg ccggtatcct gttacctgca tttattttga tcgcattagc ggctatttac     4680

ctgcactccg gtgcccccgt tgctatcgaa atggattcga agaccttctt ccctgacttc     4740

tctaaagtgg gcacactggt tgtatttgtt gccttcattt tgagttatat gggcgtagaa     4800

gcttccgcaa ctcacgtcaa tgaaatgagc aaccccgggc gcgactatcc actggctatg     4860

ttactgctga tggtggcggc aatctgctta agctctgttg gcggtttgtc tattgcgatg     4920

gtcattccgg gtaatgaaat caacctctcc gcaggggtaa tgcaaacctt taccgttctg     4980

atgtcccatg tggcaccgga aattgagtgg acggttcgcg tgatctccgc actgctgttg     5040

ctgggtgttc tggcggaaat cgcctcctgg attgttggtc cttctcgcgg gatgtatgtc     5100

acagcgcaga aaaacctgct gccagcggca ttcgctaaaa tgaacaaaaa tggcgtaccg     5160

gtaacgctgg tcatttcgca gctggtgatt acttctatcg cgttgatcat cctcaccaat     5220

accggtggcg gtaacaacat gtccttcctg atcgcactgg cgctgacggt ggtgatttat     5280

ctgtgtgctt atttcatgct gtttattggc tacattgtgt tggttcttaa acatcctgac     5340

ttaaaacgca catttaatat ccctggtggt aaaggggtga aactggtcgt ggcaattgtc     5400

ggtctgctga cttcaattat ggcgtttatt gtttccttcc tgccgccgga taacatccag     5460

ggtgattcta ccgatatgta tgttgaatta ctggttgtta gtttcctggt ggtacttgcc     5520

ctgcccttta ttctctatgc tgttcatgat cgtaaaggca aagcgaatac cggcgtcact     5580

ctggagccaa tcaacagtca gaacgcacca aaaggtcact tcttcctgca cccgcgtgca     5640

cgttcaccac actatattgt gatgaatgac aagaaacact aatctagagt cgacctgcag     5700

gcatgcaagc ttggggtacc gaattctgaa gttcctatac tttctagaga ataggaactt     5760

cggaatagga actaaggagg atattcatat caaaaaaatc atcatattac taacgacatt     5820

tttcctgctt tcgggatgca ctattcccag ggcggtattt aaatccagcc ttattaatca     5880

ggacgatcct cgttataatc tggtcgaagt cacgccgaca ttaaaactaa gcgctcccga     5940

tactgtgccg aaaactattg tcgatccggt ttttgccgca aataactggc actggacatc     6000

tttggctaaa ggcgatgtgc tgcatatcac tattttatcc tcgggcgggg ctggatattt     6060

atccaataac gcgagcggcg accgtgcgga ttttgaaaat attcttgtga ctgacagtaa     6120

taccgttcag gtgccttatg ccgggacaat cccggtttct ggattggatg tgacgcaact     6180

ggctgatgag atcaaaaagc gactttcgcg cgttgtcctg aatcctcagg tgattgtgac     6240

acttaccgcc cgcaccggag ccatggtgac ggtcgagggc agcgggaaaa cgggtcgata     6300

ccctctcgaa cagagtatga atcgtctgag tcatcttttg gcaacggcag tggcagtaga     6360

aaataccagc acagatatga tggaagttca cgtgacgcgc cagcagcatt atttcactgc     6420

gcgactgtca gatatttatc agtatcccgg attggatatt gccttacagc cggatgaccg     6480

tatcactctg cgtcaagtga ccgagtatgt taatgtgctc ggcgcagcag gtgttcaggg     6540

gaaacatgct ctggttcagc gtcattccag cgtcgtggat gctttggcgc tcgcgaaagg     6600

attaaatgac aatcttgccg atccgcaagc gatttttctg tacaagcata acgaagcgga     6660

acaggcgaaa cagcagatgc gtaagctgaa tatctatcat gtcgatatga gccaacctaa     6720

ctcggtgttt ttagcgcagg ccatacgagt ggacaacggc gatgttatct atatctcgaa     6780

cgcctctttg actgatttcg ctaaggtgaa agccgcattc gatagctttt tgacccgcgg     6840

cactaattct ttctaatgtc gccatatgaa tattttgaaa aataattctt attattttat     6900

gaaactcatt accgtctgtg agttaattat tttattgatg tcacgcgata tcaaaacacg     6960

ctataacggt aatttactaa actatatgat ggtgctggcc gtaccactgg tatggatatc     7020

cattaccgtt atttcttttc aatatttaaa tcgctcggtg ccaatatcca ctgacgatat     7080

cagttttgtt attgcaggga tattaccgta tctgttattt cgttatacca ttaccgcaac     7140


<210>  11
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gatcacatat gaaaaaaatc atcatattac taacgacatt tttcc                       45


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
gatcaggatc cttagaaaga attagtgccg cggg                                   34


<210>  13
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gatcactcga cgccggagga tctgccgtc                                         29


<210>  14
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gatcaggtac cccaagcttg catgcctgca g                                      31


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gttgcggtaa tggtataacg aaataacaga tac                                    33


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
cacgcaatat ttcaatgatg gcaac                                             25


