                         SEQUENCE LISTING

<110>  Atherotech, Inc.
       YEH, Chen-Hsiung
 
<120>  PCSK9 Activity Assay

<130>  0A9110-301008

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  860
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (314)..(353)
<223>  EGF-A domain, PCSK9 binding domain

<220>
<221>  BINDING
<222>  (314)..(393)
<223>  EGF-AB domain, PCSK9 binding domain

<400>  1

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  2
<211>  860
<212>  PRT
<213>  Pan troglodytes

<400>  2

Met Glu Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln His Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln His Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Val Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asn Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Thr Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Ile Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Ala Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys Arg Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  3
<211>  853
<212>  PRT
<213>  Macaca mulatta

<400>  3

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Phe Leu Leu 
1               5                   10                  15      


Ala Ala Ala Glu Ala Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Glu Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Thr Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Glu Val Asp Cys Glu 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Asp Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Tyr Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln His Cys Gln Gly Leu Glu Val Pro Lys Arg 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Arg Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Gly Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Pro Glu Phe Gln Cys Ser Asp Gly Thr 
225                 230                 235                 240 


Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp 
                245                 250                 255     


Met Ser Asp Glu Val Gly Cys Ile Asn Val Thr Leu Cys Glu Gly Pro 
            260                 265                 270         


Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Ser Leu Asp Lys Val 
        275                 280                 285             


Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys 
    290                 295                 300                 


Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His 
305                 310                 315                 320 


Ile Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly 
                325                 330                 335     


Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln 
            340                 345                 350         


Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Ser Tyr 
        355                 360                 365             


Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala 
    370                 375                 380                 


Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Ile Phe Thr Asn Arg His 
385                 390                 395                 400 


Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile 
                405                 410                 415     


Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn 
            420                 425                 430         


Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Tyr Ser Thr Gln 
        435                 440                 445             


Leu Asp Arg Ala His Ser Val Ser Ser Tyr Asp Thr Val Ile Ser Arg 
    450                 455                 460                 


Asp Leu Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn 
465                 470                 475                 480 


Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr 
                485                 490                 495     


Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro 
            500                 505                 510         


Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp 
        515                 520                 525             


Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp 
    530                 535                 540                 


Ile Tyr Ser Leu Val Thr Glu Asn Ile Glu Trp Pro Asn Gly Ile Thr 
545                 550                 555                 560 


Leu Asp Phe Pro Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His 
                565                 570                 575     


Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu 
            580                 585                 590         


Glu Asp Lys Glu Arg Leu Ala His Pro Phe Ser Leu Ala Ile Phe Glu 
        595                 600                 605             


Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala 
    610                 615                 620                 


Asn Arg Leu Thr Gly Ser Asp Ile Asn Leu Leu Ala Glu Asn Leu Leu 
625                 630                 635                 640 


Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly 
                645                 650                 655     


Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr 
            660                 665                 670         


Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro Gln Ser Pro Lys Phe Thr 
        675                 680                 685             


Cys Thr Cys Pro Asp Gly Met Leu Leu Ala Lys Asp Met Arg Ser Cys 
    690                 695                 700                 


Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val 
705                 710                 715                 720 


Arg Leu Met Val Ser Ser Lys Ala Val Ala Thr Gln His Thr Thr Thr 
                725                 730                 735     


Arg Pro Val Pro Asn Thr Ser Gln Leu Pro Gly Ala Thr Pro Gly Leu 
            740                 745                 750         


Thr Thr Ala Glu Thr Val Thr Met Ser His Gln Ala Leu Gly Asp Val 
        755                 760                 765             


Ala Gly Arg Gly Asn Glu Lys Lys Pro Lys Ser Val Gly Ala Leu Ser 
    770                 775                 780                 


Ile Val Leu Pro Thr Val Leu Leu Val Phe Leu Cys Leu Gly Ala Phe 
785                 790                 795                 800 


Leu Leu Trp Lys Asn Trp Arg Leu Lys Ser Ile Asn Ser Ile Asn Phe 
                805                 810                 815     


Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys 
            820                 825                 830         


Arg Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu 
        835                 840                 845             


Glu Asp Asp Val Ala 
    850             


<210>  4
<211>  682
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Val Ala Thr Cys Arg Pro Asp 
            100                 105                 110         


Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys 
        115                 120                 125             


Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val 
    130                 135                 140                 


Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
145                 150                 155                 160 


Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg 
                165                 170                 175     


Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu 
            180                 185                 190         


Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly 
        195                 200                 205             


Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg 
    210                 215                 220                 


Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu 
225                 230                 235                 240 


Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe 
                245                 250                 255     


Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala 
            260                 265                 270         


Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
        275                 280                 285             


Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala 
    290                 295                 300                 


Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
305                 310                 315                 320 


Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser 
                325                 330                 335     


Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu 
            340                 345                 350         


Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu 
        355                 360                 365             


Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu 
    370                 375                 380                 


Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val 
385                 390                 395                 400 


His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys 
                405                 410                 415     


Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn 
            420                 425                 430         


Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu 
        435                 440                 445             


Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn 
    450                 455                 460                 


Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His 
465                 470                 475                 480 


Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile 
                485                 490                 495     


Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val 
            500                 505                 510         


Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe 
        515                 520                 525             


His Asn Leu Thr Gln Pro Arg Glu Ala Glu Ala Ala Val Ala Thr Gln 
    530                 535                 540                 


Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr 
545                 550                 555                 560 


Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly 
                565                 570                 575     


Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln 
            580                 585                 590         


Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser 
        595                 600                 605             


Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu 
    610                 615                 620                 


Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile 
625                 630                 635                 640 


Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp 
                645                 650                 655     


Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg 
            660                 665                 670         


Gln Met Val Ser Leu Glu Asp Asp Val Ala 
        675                 680         


<210>  5
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Leu Thr Leu Cys Glu Gly Pro 
            100                 105                 110         


Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val 
        115                 120                 125             


Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys 
    130                 135                 140                 


Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His 
145                 150                 155                 160 


Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly 
                165                 170                 175     


Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln 
            180                 185                 190         


Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr 
        195                 200                 205             


Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala 
    210                 215                 220                 


Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His 
225                 230                 235                 240 


Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile 
                245                 250                 255     


Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn 
            260                 265                 270         


Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln 
        275                 280                 285             


Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg 
    290                 295                 300                 


Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn 
305                 310                 315                 320 


Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr 
                325                 330                 335     


Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro 
            340                 345                 350         


Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp 
        355                 360                 365             


Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp 
    370                 375                 380                 


Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr 
385                 390                 395                 400 


Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His 
                405                 410                 415     


Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu 
            420                 425                 430         


Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu 
        435                 440                 445             


Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala 
    450                 455                 460                 


Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu 
465                 470                 475                 480 


Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly 
                485                 490                 495     


Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr 
            500                 505                 510         


Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr 
        515                 520                 525             


Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys 
    530                 535                 540                 


Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val 
545                 550                 555                 560 


Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr 
                565                 570                 575     


Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu 
            580                 585                 590         


Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val 
        595                 600                 605             


Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser 
    610                 615                 620                 


Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe 
625                 630                 635                 640 


Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe 
                645                 650                 655     


Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys 
            660                 665                 670         


His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu 
        675                 680                 685             


Glu Asp Asp Val Ala 
    690             


<210>  6
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Ser 
    50                  55                  60                  


Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly Lys Cys 
65                  70                  75                  80  


Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu Asp Gly 
                85                  90                  95      


Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala Ser Phe 
            100                 105                 110         


Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn 
        115                 120                 125             


Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg 
    130                 135                 140                 


Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu 
145                 150                 155                 160 


Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp 
                165                 170                 175     


Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val 
            180                 185                 190         


Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile 
        195                 200                 205             


His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser 
    210                 215                 220                 


Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys 
225                 230                 235                 240 


Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn 
                245                 250                 255     


Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys 
            260                 265                 270         


Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
        275                 280                 285             


Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
    290                 295                 300                 


Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro 
305                 310                 315                 320 


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys 
                325                 330                 335     


Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys 
            340                 345                 350         


Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val 
        355                 360                 365             


Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn 
    370                 375                 380                 


Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile 
385                 390                 395                 400 


Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp 
                405                 410                 415     


Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile 
            420                 425                 430         


Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr 
        435                 440                 445             


Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly 
    450                 455                 460                 


Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala 
465                 470                 475                 480 


Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly 
                485                 490                 495     


Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr 
            500                 505                 510         


Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        515                 520                 525             


Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile 
    530                 535                 540                 


Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp 
545                 550                 555                 560 


Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys 
                565                 570                 575     


Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg 
            580                 585                 590         


Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro 
        595                 600                 605             


Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn 
    610                 615                 620                 


Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys 
625                 630                 635                 640 


Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala 
                645                 650                 655     


Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr 
            660                 665                 670         


Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu 
        675                 680                 685             


Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro 
    690                 695                 700                 


Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr 
705                 710                 715                 720 


Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly 
                725                 730                 735     


Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val 
            740                 745                 750         


Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu 
        755                 760                 765             


Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn 
    770                 775                 780                 


Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn 
785                 790                 795                 800 


Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp 
                805                 810                 815     


Asp Val Ala 
            


<210>  7
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855             


<210>  8
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Variant
<222>  (5)..(5)
<223>  Xaa= C, F, R, or Y

<220>
<221>  variant
<222>  (14)..(14)
<223>  Xaa= H or Y

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa= C, F or Y

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa= G or S

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa= C or S

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Xaa= D, E, or N

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Xaa= G or S

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa= R or P

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  Xaa= C or Y

<400>  8

Gly Thr Asn Glu Xaa Leu Asp Asn Asn Gly Gly Cys Ser Xaa Val Xaa 
1               5                   10                  15      


Asn Asp Leu Lys Ile Xaa Tyr Glu Xaa Leu Cys Pro Xaa Xaa Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Xaa Arg Xaa Glu 
        35                  40  


<210>  9
<211>  80
<212>  PRT
<213>  Homo sapiens


<220>
<221>  variant
<222>  (5)..(5)
<223>  Xaa = C, F, R, or Y

<220>
<221>  variant
<222>  (14)..(14)
<223>  Xaa = H or Y

<220>
<221>  variant
<222>  (16)..(16)
<223>  Xaa = C, F or Y

<220>
<221>  variant
<222>  (22)..(22)
<223>  Xaa =G or S

<220>
<221>  variant
<222>  (25)..(25)
<223>  Xaa = C or S

<220>
<221>  variant
<222>  (29)..(29)
<223>  Xaa = D, E, or N

<220>
<221>  variant
<222>  (30)..(30)
<223>  Xaa = G or S

<220>
<221>  variant
<222>  (37)..(37)
<223>  Xaa = R or P

<220>
<221>  variant
<222>  (39)..(39)
<223>  Xaa  = C or Y

<220>
<221>  variant
<222>  (41)..(41)
<223>  Xaa = D, G, or V

<220>
<221>  variant
<222>  (43)..(43)
<223>  Xaa = D or Y

<220>
<221>  variant
<222>  (44)..(44)
<223>  Xaa = E or K

<220>
<221>  variant
<222>  (45)..(45)
<223>  Xaa = C or Y

<220>
<221>  variant
<222>  (51)..(51)
<223>  Xaa = C or R

<220>
<221>  variant
<222>  (55)..(55)
<223>  Xaa = C or R

<220>
<221>  variant
<222>  (57)..(57)
<223>  Xaa = N or T

<220>
<221>  variant
<222>  (66)..(66)
<223>  Xaa = C, Y or R

<220>
<221>  variant
<222>  (78)..(78)
<223>  Xaa = A or T

<400>  9

Gly Thr Asn Glu Xaa Leu Asp Asn Asn Gly Gly Cys Ser Xaa Val Xaa 
1               5                   10                  15      


Asn Asp Leu Lys Ile Xaa Tyr Glu Xaa Leu Cys Pro Xaa Xaa Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Xaa Arg Xaa Glu Xaa Ile Xaa Xaa Xaa Gln Asp Pro 
        35                  40                  45              


Asp Thr Xaa Ser Gln Leu Xaa Val Xaa Leu Glu Gly Gly Tyr Lys Cys 
    50                  55                  60                  


Gln Xaa Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Xaa Cys Lys 
65                  70                  75                  80  


<210>  10
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus between Homo sapiens, Pan troglodytes, and Macaca 
       mulatta


<220>
<221>  Variant
<222>  (15)..(15)
<223>  Xaa = V or I

<220>
<221>  Variant
<222>  (47)..(47)
<223>  Xaa = D or H

<220>
<221>  Variant
<222>  (61)..(61)
<223>  Xaa = G or S

<400>  10

Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Xaa Cys 
1               5                   10                  15      


Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Xaa Pro 
        35                  40                  45              


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Xaa Tyr Lys Cys 
    50                  55                  60                  


Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys 
65                  70                  75                  80  


<210>  11
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus between Homo sapiens, Pan troglodytes, Macaca mulatta, 
       Mus musculus, and Rattus norvegicus


<220>
<221>  Variant
<222>  (15)..(15)
<223>  Xaa = V or I

<220>
<221>  Variant
<222>  (17)..(17)
<223>  Xaa = G or S

<220>
<221>  Variant
<222>  (23)..(23)
<223>  Xaa = Y or S

<220>
<221>  Variant
<222>  (29)..(29)
<223>  Xaa = D or S

<220>
<221>  Variant
<222>  (32)..(32)
<223>  Xaa = Q or L

<220>
<221>  Variant
<222>  (35)..(35)
<223>  Xaa = A or D

<220>
<221>  Variant
<222>  (36)..(36)
<223>  Xaa = Q or L

<220>
<221>  Variant
<222>  (37)..(37)
<223>  Xaa = R or H

<220>
<221>  Variant
<222>  (37)..(37)
<223>  Xaa = R or H

<220>
<221>  Variant
<222>  (47)..(47)
<223>  Xaa = D, E or H

<220>
<221>  Variant
<222>  (61)..(61)
<223>  Xaa = G or S

<220>
<221>  Variant
<222>  (65)..(65)
<223>  Xaa = Q or E

<220>
<221>  Variant
<222>  (67)..(67)
<223>  Xaa = Q or E

<220>
<221>  Variant
<222>  (68)..(68)
<223>  Xaa = A or E

<220>
<221>  Variant
<222>  (71)..(71)
<223>  Xaa = Q or H

<220>
<221>  Variant
<222>  (72)..(72)
<223>  Xaa = L or M

<220>
<221>  Variant
<222>  (77)..(77)
<223>  Xaa = K or R

<220>
<221>  Variant
<222>  (78)..(78)
<223>  Xaa = A or V

<400>  11

Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Xaa Cys 
1               5                   10                  15      


Xaa Asp Leu Lys Ile Gly Xaa Glu Cys Leu Cys Pro Xaa Gly Phe Xaa 
            20                  25                  30          


Leu Val Xaa Xaa Xaa Arg Cys Glu Asp Ile Asp Glu Cys Gln Xaa Pro 
        35                  40                  45              


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Xaa Tyr Lys Cys 
    50                  55                  60                  


Xaa Cys Xaa Xaa Gly Phe Xaa Xaa Asp Pro His Thr Xaa Xaa Cys Lys 
65                  70                  75                  80  


<210>  12
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  13
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Ala Leu Pro Pro Ser Thr His 
    290                 295         


<210>  14
<211>  297
<212>  PRT
<213>  Homo sapiens


<220>
<221>  variant
<222>  (5)..(5)
<223>  Xaa = N or K

<220>
<221>  variant
<222>  (22)..(22)
<223>  Xaa = P or S

<220>
<221>  variant
<222>  (63)..(63)
<223>  Xaa = R or H

<220>
<221>  variant
<222>  (64)..(64)
<223>  Xaa = F or L

<220>
<221>  variant
<222>  (66)..(66)
<223>  Xaa = R or S

<220>
<221>  variant
<222>  (67)..(67)
<223>  Xaa = Q or E

<220>
<221>  variant
<222>  (85)..(85)
<223>  Xaa = R or W

<220>
<221>  variant
<222>  (87)..(87)
<223>  Xaa = A or D

<220>
<221>  variant
<222>  (101)..(101)
<223>  Xaa = L or F

<220>
<221>  variant
<222>  (205)..(205)
<223>  Xaa = R or H

<220>
<221>  variant
<222>  (222)..(222)
<223>  Xaa = D, H, or Y

<220>
<221>  variant
<222>  (239)..(239)
<223>  Xaa = H or N

<220>
<221>  variant
<222>  (242)..(242)
<223>  Xaa = G or S

<220>
<221>  variant
<222>  (265)..(265)
<223>  Xaa = H or Q

<220>
<221>  variant
<222>  (273)..(273)
<223>  Xaa = N or S

<220>
<221>  variant
<222>  (291)..(291)
<223>  Xaa = A or T

<400>  14

Ser Ile Pro Trp Xaa Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Xaa Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Xaa Xaa 
    50                  55                  60                  


His Xaa Xaa Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Xaa Asp Xaa Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Xaa Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Xaa Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Xaa Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala Xaa Val 
225                 230                 235                 240 


Ala Xaa Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile Xaa Phe Ser Ala Lys Asp Val Ile 
            260                 265                 270         


Xaa Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu 
        275                 280                 285             


Val Ala Xaa Leu Pro Pro Ser Thr His 
    290                 295         


<210>  15
<211>  862
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ser Thr Ala Asp Leu Met Arg Arg Trp Val Ile Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Val Ala Ala Glu Asp Ser Cys Ser Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Arg Asp Gly Lys Cys Ile Ala Ser Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Pro Glu Cys Pro Asp Gly Ser Asp Glu Ser Pro Glu Thr Cys Met 
    50                  55                  60                  


Ser Val Thr Cys Gln Ser Asn Gln Phe Ser Cys Gly Gly Arg Val Ser 
65                  70                  75                  80  


Arg Cys Ile Pro Asp Ser Trp Arg Cys Asp Gly Gln Val Asp Cys Glu 
                85                  90                  95      


Asn Asp Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Asp Phe Arg Cys Gln Asp Gly Lys Cys Ile Ser Pro Gln Phe Val Cys 
        115                 120                 125             


Asp Gly Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala His Cys Gln 
    130                 135                 140                 


Ala Thr Thr Cys Gly Pro Ala His Phe Arg Cys Asn Ser Ser Ile Cys 
145                 150                 155                 160 


Ile Pro Ser Leu Trp Ala Cys Asp Gly Asp Val Asp Cys Val Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Asn Cys Gln Gly Arg Asp Thr Ala Ser Lys 
            180                 185                 190         


Gly Val Ser Ser Pro Cys Ser Ser Leu Glu Phe His Cys Gly Ser Ser 
        195                 200                 205             


Glu Cys Ile His Arg Ser Trp Val Cys Asp Gly Glu Ala Asp Cys Lys 
    210                 215                 220                 


Asp Lys Ser Asp Glu Glu His Cys Ala Val Ala Thr Cys Arg Pro Asp 
225                 230                 235                 240 


Glu Phe Gln Cys Ala Asp Gly Ser Cys Ile His Gly Ser Arg Gln Cys 
                245                 250                 255     


Asp Arg Glu His Asp Cys Lys Asp Met Ser Asp Glu Leu Gly Cys Val 
            260                 265                 270         


Asn Val Thr Gln Cys Asp Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
        275                 280                 285             


Glu Cys Ile Ser Leu Asp Lys Val Cys Asp Ser Ala Arg Asp Cys Gln 
    290                 295                 300                 


Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Lys Thr Asn Glu Cys Leu 
305                 310                 315                 320 


Asp Asn Asn Gly Gly Cys Ser His Ile Cys Lys Asp Leu Lys Ile Gly 
                325                 330                 335     


Ser Glu Cys Leu Cys Pro Ser Gly Phe Arg Leu Val Asp Leu His Arg 
            340                 345                 350         


Cys Glu Asp Ile Asp Glu Cys Gln Glu Pro Asp Thr Cys Ser Gln Leu 
        355                 360                 365             


Cys Val Asn Leu Glu Gly Ser Tyr Lys Cys Glu Cys Gln Ala Gly Phe 
    370                 375                 380                 


His Met Asp Pro His Thr Arg Val Cys Lys Ala Val Gly Ser Ile Gly 
385                 390                 395                 400 


Tyr Leu Leu Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
                405                 410                 415     


Arg Ser Glu Tyr Thr Ser Leu Leu Pro Asn Leu Lys Asn Val Val Ala 
            420                 425                 430         


Leu Asp Thr Glu Val Thr Asn Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
        435                 440                 445             


Gln Lys Lys Ile Tyr Ser Ala Leu Met Asp Gln Ala Pro Asn Leu Ser 
    450                 455                 460                 


Tyr Asp Thr Ile Ile Ser Glu Asp Leu His Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Arg Asn Ile Tyr Trp Thr Asp Ser Val Pro Gly 
                485                 490                 495     


Ser Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Arg Thr Leu Phe 
            500                 505                 510         


Gln Glu Ala Gly Ser Arg Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile His Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Ser Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Asn Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Ile Tyr Glu Asp Lys Val Tyr Trp Thr Asp Val Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Val Ala Glu Asn Leu Leu Ser Pro Glu Asp Ile Val Leu Phe His 
                645                 650                 655     


Lys Val Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Thr Thr Ala Leu 
            660                 665                 670         


Leu Pro Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile 
        675                 680                 685             


Gly Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu 
    690                 695                 700                 


Leu Ala Lys Asp Met Arg Ser Cys Leu Thr Glu Val Asp Thr Val Leu 
705                 710                 715                 720 


Thr Thr Gln Gly Thr Ser Ala Val Arg Pro Val Val Thr Ala Ser Ala 
                725                 730                 735     


Thr Arg Pro Pro Lys His Ser Glu Asp Leu Ser Ala Pro Ser Thr Pro 
            740                 745                 750         


Arg Gln Pro Val Asp Thr Pro Gly Leu Ser Thr Val Ala Ser Val Thr 
        755                 760                 765             


Val Ser His Gln Val Gln Gly Asp Met Ala Gly Arg Gly Asn Glu Glu 
    770                 775                 780                 


Gln Pro His Gly Met Arg Phe Leu Ser Ile Phe Phe Pro Ile Ala Leu 
785                 790                 795                 800 


Val Ala Leu Leu Val Leu Gly Ala Val Leu Leu Trp Arg Asn Trp Arg 
                805                 810                 815     


Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys 
            820                 825                 830         


Thr Thr Glu Asp Glu Leu His Ile Cys Arg Ser Gln Asp Gly Tyr Thr 
        835                 840                 845             


Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860         


<210>  16
<211>  879
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Ser Thr Ala Asp Leu Met Leu Arg Trp Ala Ile Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Val Ala Ala Glu Asp Ser Cys Gly Lys Asn Glu Phe 
            20                  25                  30          


Gln Cys Arg Asp Gly Lys Cys Ile Val Ser Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Arg Glu Cys Pro Asp Gly Ser Asp Glu Ser Pro Glu Thr Cys Met 
    50                  55                  60                  


Ser Val Thr Cys Arg Ser Gly Glu Phe Ser Cys Gly Gly Arg Val Ser 
65                  70                  75                  80  


Arg Cys Ile Pro Asp Ser Trp Arg Cys Asp Gly Arg Thr Asp Cys Glu 
                85                  90                  95      


Asn Gly Ser Asp Glu Leu Asp Cys Ser Pro Lys Thr Cys Ser Leu Asp 
            100                 105                 110         


Glu Phe Arg Cys Gln Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Gln Asp Trp Asp Cys Leu Asp Gly Ser Asp Glu Ala His Cys Ala 
    130                 135                 140                 


Ala Thr Thr Cys Gly Pro Ala His Phe Arg Cys Asn Ser Ser Ser Cys 
145                 150                 155                 160 


Ile Pro Ser Leu Trp Ala Cys Asp Gly Asp Arg Asp Cys Asp Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Asn Cys Gly Ala Glu Asp Thr Ala Ala Glu 
            180                 185                 190         


Val Val Ser Ser Pro Cys Ser Ser Leu Glu Phe His Cys Gly Ser Ser 
        195                 200                 205             


Glu Cys Ile His Arg Ser Trp Val Cys Asp Gly Ala Ala Asp Cys Lys 
    210                 215                 220                 


Asp Lys Ser Asp Glu Glu Asn Cys Ala Val Thr Thr Cys Arg Pro Asp 
225                 230                 235                 240 


Glu Phe Gln Cys Ala Asp Gly Ser Cys Ile His Gly Ser Arg Gln Cys 
                245                 250                 255     


Asp Arg Glu His Asp Cys Lys Asp Met Ser Asp Glu Leu Gly Cys Ile 
            260                 265                 270         


Asn Val Thr Gln Cys Asp Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
        275                 280                 285             


Glu Cys Ile Ser Leu Asp Lys Val Cys Asn Ser Ala Arg Asp Cys Arg 
    290                 295                 300                 


Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Lys Thr Asn Glu Cys Leu 
305                 310                 315                 320 


Asp Asn Asn Gly Gly Cys Ser His Ile Cys Lys Asp Leu Lys Ile Gly 
                325                 330                 335     


Tyr Glu Cys Leu Cys Pro Ser Gly Phe Arg Leu Val Asp Gly His Gln 
            340                 345                 350         


Cys Glu Asp Ile Asp Glu Cys Gln Glu Pro Asp Thr Cys Ser Gln Leu 
        355                 360                 365             


Cys Val Asn Leu Glu Gly Ser Phe Lys Cys Glu Cys Arg Ala Gly Phe 
    370                 375                 380                 


His Met Asp Pro His Thr Arg Val Cys Lys Ala Val Gly Ser Ile Gly 
385                 390                 395                 400 


Phe Leu Leu Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
                405                 410                 415     


Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Lys Asn Val Val Ala 
            420                 425                 430         


Leu Asp Thr Glu Val Ala Asn Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
        435                 440                 445             


Gln Arg Lys Ile Tyr Ser Ala Val Met Asp Gln Gly Thr Ser Leu Ser 
    450                 455                 460                 


Tyr Asp Ala Ile Ile Ser Gly Asp Leu His Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Gly Asn Ile Tyr Trp Thr Asp Ser Val Pro Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Arg Arg Arg Thr Leu Phe 
            500                 505                 510         


Arg Glu Lys Gly Ser Arg Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asp Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Pro Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Gly Arg Lys Thr Ile Leu Glu Asp Glu Lys Gln Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Ile Tyr Glu Asp Lys Val Tyr Trp Thr Asp Val Leu 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Val Ala Lys Asn Leu Met Ser Pro Glu Asp Ile Val Leu Phe His 
                645                 650                 655     


Asn Val Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Ala Thr Val Leu 
            660                 665                 670         


Pro Asn Gly Gly Cys Gln Tyr Met Cys Leu Pro Ala Pro Gln Ile Ser 
        675                 680                 685             


Ala His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Lys Asp Met Arg Ser Cys Leu Pro Glu Val Asp Thr Val Pro Thr 
705                 710                 715                 720 


Thr Gln Gly Thr Ser Thr Ile Gly Pro Val Val Thr Thr Ser Ala Ala 
                725                 730                 735     


Val Ser Leu Lys Arg Lys Glu Asp Pro Ser Ala Thr Arg His Lys Glu 
            740                 745                 750         


Asp Pro Ser Ala Thr Arg His Asn Glu Asp Pro Ser Ala Thr Ser Thr 
        755                 760                 765             


Ser Arg Gln Pro Gly Asp Thr Pro Glu Leu Ser Thr Val Glu Ser Val 
    770                 775                 780                 


Thr Val Ser Ser Gln Val Gln Gly Asp Met Ala Gly Arg Gly Asp Glu 
785                 790                 795                 800 


Val Gln Arg His Gly Val Gly Phe Leu Ser Ile Phe Leu Pro Ile Ala 
                805                 810                 815     


Leu Val Ala Leu Leu Val Phe Gly Ala Ile Leu Leu Trp Arg Asn Trp 
            820                 825                 830         


Arg Leu Arg Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln 
        835                 840                 845             


Lys Thr Thr Glu Asp Glu Ile His Ile Cys Arg Ser Gln Asp Gly Tyr 
    850                 855                 860                 


Thr Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
865                 870                 875                 


<210>  17
<211>  692
<212>  PRT
<213>  Pan troglodytes

<400>  17

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Ile His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Gly Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Met Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys Arg Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Ala Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Ala Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  18
<211>  692
<212>  PRT
<213>  Macaca mulatta

<400>  18

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Asp Ala Pro Glu His Gly Ala Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Arg Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His His Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Ala Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Lys Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Ser Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Gly Leu Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Phe Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Arg Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Arg Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Gln Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Ile Glu Ala Gln Gly Gly Lys Arg Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Val Asn Cys Ser Val His Thr Ala Pro Pro Ala Gly Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Ile Val 
    610                 615                 620                 


Ala Cys Glu Asp Gly Trp Thr Leu Thr Gly Cys Ser Pro Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Lys Glu Ala Val 
            660                 665                 670         


Ala Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Val Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  19
<211>  694
<212>  PRT
<213>  Mus musculus

<400>  19

Met Gly Thr His Cys Ser Ala Trp Leu Arg Trp Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ala 
            20                  25                  30          


Gly Ala Gln Asp Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu 
        35                  40                  45              


Pro Ser Gln Glu Asp Gly Leu Ala Asp Glu Ala Ala His Val Ala Thr 
    50                  55                  60                  


Ala Thr Phe Arg Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr 
65                  70                  75                  80  


Tyr Ile Val Val Leu Met Glu Glu Thr Gln Arg Leu Gln Ile Glu Gln 
                85                  90                  95      


Thr Ala His Arg Leu Gln Thr Arg Ala Ala Arg Arg Gly Tyr Val Ile 
            100                 105                 110         


Lys Val Leu His Ile Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys 
        115                 120                 125             


Met Ser Ser Asp Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu 
    130                 135                 140                 


Tyr Ile Glu Glu Asp Ser Phe Val Phe Ala Gln Ser Ile Pro Trp Asn 
145                 150                 155                 160 


Leu Glu Arg Ile Ile Pro Ala Trp His Gln Thr Glu Glu Asp Arg Ser 
                165                 170                 175     


Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile 
            180                 185                 190         


Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe 
        195                 200                 205             


Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser 
    210                 215                 220                 


Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg 
225                 230                 235                 240 


Asp Ala Gly Val Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu 
                245                 250                 255     


Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu 
            260                 265                 270         


Phe Ile Arg Lys Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val 
        275                 280                 285             


Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Ile Leu Asn Ala Ala Cys 
    290                 295                 300                 


Arg His Leu Ala Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn 
305                 310                 315                 320 


Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val 
                325                 330                 335     


Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly 
            340                 345                 350         


Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly 
        355                 360                 365             


Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Met Ser 
    370                 375                 380                 


Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala 
385                 390                 395                 400 


Arg Met Leu Ser Arg Glu Pro Thr Leu Thr Leu Ala Glu Leu Arg Gln 
                405                 410                 415     


Arg Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe 
            420                 425                 430         


Pro Glu Asp Gln Gln Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro 
        435                 440                 445             


Pro Ser Thr His Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val Trp 
    450                 455                 460                 


Ser Ala His Ser Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala Arg Cys 
465                 470                 475                 480 


Ala Pro Glu Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly 
                485                 490                 495     


Arg Arg Arg Gly Asp Trp Ile Glu Ala Ile Gly Gly Gln Gln Val Cys 
            500                 505                 510         


Lys Ala Leu Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg 
        515                 520                 525             


Cys Cys Leu Val Pro Arg Ala Asn Cys Ser Ile His Asn Thr Pro Ala 
    530                 535                 540                 


Ala Arg Ala Gly Leu Glu Thr His Val His Cys His Gln Lys Asp His 
545                 550                 555                 560 


Val Leu Thr Gly Cys Ser Phe His Trp Glu Val Glu Asp Leu Ser Val 
                565                 570                 575     


Arg Arg Gln Pro Ala Leu Arg Ser Arg Arg Gln Pro Gly Gln Cys Val 
            580                 585                 590         


Gly His Gln Ala Ala Ser Val Tyr Ala Ser Cys Cys His Ala Pro Gly 
        595                 600                 605             


Leu Glu Cys Lys Ile Lys Glu His Gly Ile Ser Gly Pro Ser Glu Gln 
    610                 615                 620                 


Val Thr Val Ala Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys Asn Val 
625                 630                 635                 640 


Leu Pro Gly Ala Ser Leu Thr Leu Gly Ala Tyr Ser Val Asp Asn Leu 
                645                 650                 655     


Cys Val Ala Arg Val His Asp Thr Ala Arg Ala Asp Arg Thr Ser Gly 
            660                 665                 670         


Glu Ala Thr Val Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala 
        675                 680                 685             


Lys Ala Ser Trp Val Gln 
    690                 


<210>  20
<211>  691
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Met Gly Ile Arg Cys Ser Thr Trp Leu Arg Trp Pro Leu Ser Pro Gln 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ser Arg Ala Gln Asp 
            20                  25                  30          


Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu Pro Ser Gln Glu 
        35                  40                  45              


Asp Ser Leu Val Asp Glu Ala Ser His Val Ala Thr Ala Thr Phe Arg 
    50                  55                  60                  


Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr Tyr Val Val Val 
65                  70                  75                  80  


Leu Met Glu Glu Thr Gln Arg Leu Gln Val Glu Gln Thr Ala His Arg 
                85                  90                  95      


Leu Gln Thr Trp Ala Ala Arg Arg Gly Tyr Val Ile Lys Val Leu His 
            100                 105                 110         


Val Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys Met Ser Ser Asp 
        115                 120                 125             


Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu Tyr Ile Glu Glu 
    130                 135                 140                 


Asp Ser Leu Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile 
145                 150                 155                 160 


Ile Pro Ala Trp Gln Gln Thr Glu Glu Asp Ser Ser Pro Asp Gly Ser 
                165                 170                 175     


Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Gly His 
            180                 185                 190         


Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe Asn Ser Val Pro 
        195                 200                 205             


Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser 
    210                 215                 220                 


His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val 
225                 230                 235                 240 


Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu Asn Cys Gln Gly 
                245                 250                 255     


Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys 
            260                 265                 270         


Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val Leu Leu Pro Leu 
        275                 280                 285             


Ala Gly Gly Tyr Ser Arg Ile Leu Asn Thr Ala Cys Gln Arg Leu Ala 
    290                 295                 300                 


Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn Phe Arg Asp Asp 
305                 310                 315                 320 


Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly 
                325                 330                 335     


Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr 
            340                 345                 350         


Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Lys Asp Ile Ile 
        355                 360                 365             


Gly Ala Ser Ser Asp Cys Ser Thr Cys Tyr Met Ser Gln Ser Gly Thr 
    370                 375                 380                 


Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala Met Met Leu Asn 
385                 390                 395                 400 


Arg Asp Pro Ala Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile Leu 
                405                 410                 415     


Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe Pro Glu Asp Gln 
            420                 425                 430         


Arg Val Leu Thr Pro Asn Arg Val Ala Thr Leu Pro Pro Ser Thr Gln 
        435                 440                 445             


Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val Trp Ser Ala His Ser 
    450                 455                 460                 


Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala Arg Cys Ala Pro Glu Glu 
465                 470                 475                 480 


Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Arg Arg Arg Gly 
                485                 490                 495     


Asp Arg Ile Glu Ala Ile Gly Gly Gln Gln Val Cys Lys Ala Leu Asn 
            500                 505                 510         


Ala Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg Cys Cys Leu Leu 
        515                 520                 525             


Pro Arg Val Asn Cys Ser Ile His Asn Thr Pro Ala Ala Arg Ala Gly 
    530                 535                 540                 


Pro Gln Thr Pro Val His Cys His Gln Lys Asp His Val Leu Thr Gly 
545                 550                 555                 560 


Cys Ser Phe His Trp Glu Val Glu Asn Leu Arg Ala Gln Gln Gln Pro 
                565                 570                 575     


Leu Leu Arg Ser Arg His Gln Pro Gly Gln Cys Val Gly His Gln Glu 
            580                 585                 590         


Ala Ser Val His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys Lys 
        595                 600                 605             


Ile Lys Glu His Gly Ile Ala Gly Pro Ala Glu Gln Val Thr Val Ala 
    610                 615                 620                 


Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys Asn Val Leu Pro Gly Ala 
625                 630                 635                 640 


Ser Leu Pro Leu Gly Ala Tyr Ser Val Asp Asn Val Cys Val Ala Arg 
                645                 650                 655     


Ile Arg Asp Ala Gly Arg Ala Asp Arg Thr Ser Glu Glu Ala Thr Val 
            660                 665                 670         


Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala Lys Ala Ser Trp 
        675                 680                 685             


Val His Gln 
    690     


<210>  21
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus between Homo sapiens, Pan troglodytes, and Macaca 
       mulatta


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (246)..(247)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (382)..(382)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (450)..(450)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (479)..(479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (500)..(500)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (507)..(507)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (532)..(532)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (536)..(536)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (543)..(543)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (545)..(545)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (578)..(578)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (602)..(602)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (623)..(623)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (628)..(628)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (637)..(637)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (664)..(664)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (669)..(670)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (673)..(673)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (685)..(685)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Xaa 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Xaa Ala Pro Glu His Gly Xaa Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Xaa Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Xaa Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Xaa Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Xaa Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Xaa Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Xaa Xaa Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Xaa Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Xaa Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Xaa Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Xaa Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Xaa Glu Ala Gln Gly Gly Lys Xaa Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Xaa Asn Cys Ser Xaa His Thr Ala Pro Pro Ala Xaa Ala 
    530                 535                 540                 


Xaa Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Xaa Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys Xaa Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Xaa Val 
    610                 615                 620                 


Ala Cys Glu Xaa Gly Trp Thr Leu Thr Gly Cys Ser Xaa Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Xaa Gly Ser Thr Ser Xaa Xaa Ala Val 
            660                 665                 670         


Xaa Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Xaa Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  22
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus between Homo sapiens, Pan troglodytes, Macaca mulatta, 
       Mus musculus, and Rattus norvegicus.


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (163)..(168)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(172)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(174)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (176)..(176)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (190)..(191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (200)..(201)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (205)..(206)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (244)..(247)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (279)..(279)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (295)..(296)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (298)..(298)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (301)..(302)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (306)..(306)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (312)..(312)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (378)..(379)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (381)..(381)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (397)..(397)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (400)..(402)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (404)..(404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (419)..(419)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (425)..(425)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (439)..(439)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (442)..(442)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (448)..(450)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (452)..(452)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (455)..(455)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (469)..(469)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (473)..(473)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (478)..(479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (493)..(493)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (497)..(499)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (502)..(502)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (505)..(506)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (509)..(509)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (511)..(511)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (522)..(522)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (528)..(528)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (530)..(531)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (535)..(535)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (537)..(538)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (540)..(540)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (542)..(542)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (544)..(546)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (548)..(548)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (554)..(555)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (563)..(563)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (569)..(569)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (571)..(575)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (577)..(577)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (580)..(580)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (582)..(582)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (585)..(585)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (591)..(592)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (595)..(596)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (601)..(601)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (609)..(609)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (615)..(616)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (618)..(618)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (622)..(622)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (627)..(627)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (635)..(636)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (640)..(640)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (642)..(643)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (648)..(648)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (652)..(652)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (655)..(655)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (657)..(658)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (660)..(665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (668)..(669)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (671)..(672)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (674)..(674)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (682)..(685)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (688)..(691)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Met Gly Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Trp Pro Leu Xaa Xaa Xaa 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Xaa Pro Xaa Gly Xaa Xaa Ala Xaa Asp 
            20                  25                  30          


Glu Asp Gly Asp Tyr Glu Glu Leu Xaa Leu Ala Leu Xaa Ser Xaa Glu 
        35                  40                  45              


Asp Xaa Leu Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Thr Ala Thr Phe Xaa 
    50                  55                  60                  


Arg Cys Xaa Lys Xaa Xaa Trp Arg Leu Pro Gly Thr Tyr Xaa Val Val 
65                  70                  75                  80  


Leu Xaa Glu Glu Thr Xaa Xaa Xaa Gln Xaa Glu Xaa Thr Ala Xaa Arg 
                85                  90                  95      


Leu Gln Xaa Xaa Ala Ala Arg Arg Gly Tyr Xaa Xaa Lys Xaa Leu His 
            100                 105                 110         


Xaa Phe Xaa Xaa Leu Xaa Pro Gly Phe Leu Val Lys Met Ser Xaa Asp 
        115                 120                 125             


Leu Leu Xaa Leu Ala Leu Lys Leu Pro His Val Xaa Tyr Ile Glu Glu 
    130                 135                 140                 


Asp Ser Xaa Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile 
145                 150                 155                 160 


Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Pro Xaa Gly Xaa 
                165                 170                 175     


Ser Xaa Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Xaa Xaa His 
            180                 185                 190         


Arg Glu Ile Glu Gly Arg Val Xaa Xaa Thr Asp Phe Xaa Xaa Val Pro 
        195                 200                 205             


Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser 
    210                 215                 220                 


His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val 
225                 230                 235                 240 


Ala Lys Gly Xaa Xaa Xaa Xaa Ser Leu Arg Val Leu Asn Cys Gln Gly 
                245                 250                 255     


Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys 
            260                 265                 270         


Ser Gln Leu Xaa Gln Pro Xaa Gly Pro Leu Val Val Leu Leu Pro Leu 
        275                 280                 285             


Ala Gly Gly Tyr Ser Arg Xaa Xaa Asn Xaa Ala Cys Xaa Xaa Leu Ala 
    290                 295                 300                 


Arg Xaa Gly Val Val Leu Val Xaa Ala Ala Gly Asn Phe Arg Asp Asp 
305                 310                 315                 320 


Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly 
                325                 330                 335     


Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr 
            340                 345                 350         


Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Xaa Asp Ile Ile 
        355                 360                 365             


Gly Ala Ser Ser Asp Cys Ser Thr Cys Xaa Xaa Ser Xaa Ser Gly Thr 
    370                 375                 380                 


Ser Gln Ala Ala Ala His Val Ala Gly Ile Xaa Ala Xaa Met Leu Xaa 
385                 390                 395                 400 


Xaa Xaa Pro Xaa Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile Xaa 
                405                 410                 415     


Phe Ser Xaa Lys Asp Val Ile Asn Xaa Ala Trp Phe Pro Glu Asp Gln 
            420                 425                 430         


Xaa Val Leu Thr Pro Asn Xaa Val Ala Xaa Leu Pro Pro Ser Thr Xaa 
        435                 440                 445             


Xaa Xaa Gly Xaa Gln Leu Xaa Cys Arg Thr Val Trp Ser Ala His Ser 
    450                 455                 460                 


Gly Pro Thr Arg Xaa Ala Thr Ala Xaa Ala Arg Cys Ala Xaa Xaa Glu 
465                 470                 475                 480 


Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Xaa Arg Arg Gly 
                485                 490                 495     


Xaa Xaa Xaa Glu Ala Xaa Gly Gly Xaa Xaa Val Cys Xaa Ala Xaa Asn 
            500                 505                 510         


Ala Phe Gly Gly Glu Gly Val Tyr Ala Xaa Ala Arg Cys Cys Leu Xaa 
        515                 520                 525             


Pro Xaa Xaa Asn Cys Ser Xaa His Xaa Xaa Pro Xaa Ala Xaa Ala Xaa 
    530                 535                 540                 


Xaa Xaa Thr Xaa Val His Cys His Gln Xaa Xaa His Val Leu Thr Gly 
545                 550                 555                 560 


Cys Ser Xaa His Trp Glu Val Glu Xaa Leu Xaa Xaa Xaa Xaa Xaa Pro 
                565                 570                 575     


Xaa Leu Arg Xaa Arg Xaa Gln Pro Xaa Gln Cys Val Gly His Xaa Xaa 
            580                 585                 590         


Ala Ser Xaa Xaa Ala Ser Cys Cys Xaa Ala Pro Gly Leu Glu Cys Lys 
        595                 600                 605             


Xaa Lys Glu His Gly Ile Xaa Xaa Pro Xaa Glu Gln Val Xaa Val Ala 
    610                 615                 620                 


Cys Glu Xaa Gly Trp Thr Leu Thr Gly Cys Xaa Xaa Leu Pro Gly Xaa 
625                 630                 635                 640 


Ser Xaa Xaa Leu Gly Ala Tyr Xaa Val Asp Asn Xaa Cys Val Xaa Arg 
                645                 650                 655     


Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Thr Ser Xaa Xaa Ala Xaa Xaa 
            660                 665                 670         


Ala Xaa Ala Ile Cys Cys Arg Ser Arg Xaa Xaa Xaa Xaa Ala Ser Xaa 
        675                 680                 685             


Xaa Xaa Xaa 
    690     


<210>  23
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus between Homo sapiens, Pan troglodytes, Macaca mulatta, 
       Mus musculus, and Rattus norvegicus.


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (150)..(151)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (227)..(228)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (230)..(230)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (244)..(244)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (246)..(246)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (249)..(251)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (265)..(265)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (291)..(291)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Ser Ile Pro Trp Asn Leu Glu Arg Ile Xaa Pro Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Glu Xaa Xaa Xaa Pro Xaa Gly Xaa Ser Xaa Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Xaa Xaa His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Xaa Xaa Thr Asp Phe Xaa Xaa Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Xaa Xaa Xaa Xaa 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Xaa Gln Pro Xaa 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Xaa 
    130                 135                 140                 


Xaa Asn Xaa Ala Cys Xaa Xaa Leu Ala Arg Xaa Gly Val Val Leu Val 
145                 150                 155                 160 


Xaa Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Xaa Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Xaa Xaa Ser Xaa Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Xaa Ala Xaa Met Leu Xaa Xaa Xaa Pro Xaa Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile Xaa Phe Ser Xaa Lys Asp Val Ile 
            260                 265                 270         


Asn Xaa Ala Trp Phe Pro Glu Asp Gln Xaa Val Leu Thr Pro Asn Xaa 
        275                 280                 285             


Val Ala Xaa Leu Pro Pro Ser Thr Xaa 
    290                 295         


<210>  24
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Gly Thr Asn Glu Xaa Leu Asp Asn Asn Gly Gly Cys Ser Xaa Val Xaa 
1               5                   10                  15      


Asn Asp Leu Lys Ile Xaa Tyr Glu Xaa Leu Cys Pro Xaa Xaa Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Xaa Arg Xaa Glu 
        35                  40  


<210>  25
<211>  80
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Gly Thr Asn Glu Xaa Leu Asp Asn Asn Gly Gly Cys Ser Xaa Val Xaa 
1               5                   10                  15      


Asn Asp Leu Lys Ile Xaa Tyr Glu Xaa Leu Cys Pro Xaa Xaa Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Xaa Arg Xaa Glu Xaa Ile Xaa Xaa Xaa Gln Asp Pro 
        35                  40                  45              


Asp Thr Xaa Ser Gln Leu Xaa Val Xaa Leu Glu Gly Gly Tyr Lys Cys 
    50                  55                  60                  


Gln Xaa Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Xaa Cys Lys 
65                  70                  75                  80  


<210>  26
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDLR PCSK9 binding domain mammalian consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = A,C,D,E,G,H,K,N,Q,R,S, or T

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa = I, L, or V

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa = C,D,E,H,K,N,Q,R,S, or T

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa = any

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Xaa = A,C,D,G,N,P,S,T,or V

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Xaa = C,D,E,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  Xaa = A,C,D,G,N,P,S,T,or V

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  Xaa = any

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa = H, K,or R

<220>
<221>  VARIANT
<222>  (38)..(38)
<223>  Xaa = C,D,E,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Xaa = D,E,H,K,or R

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  Xaa = A,G, or S

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  Xaa = F,H,W,or Y

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  Xaa = C,D,E,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  Xaa = C,D,E,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Xaa = A,C,D,E,G,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Xaa =C,D,E,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Xaa = A,C,F,G,H,I,K,L,M,R,T,V,W,or Y

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Xaa = H,K,or R

<220>
<221>  VARIANT
<222>  (78)..(78)
<223>  Xaa = A,C,D,G,N,P,S,T,or V

<400>  26

Xaa Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Xaa Cys 
1               5                   10                  15      


Xaa Asp Leu Lys Ile Gly Xaa Glu Cys Leu Cys Pro Xaa Gly Phe Xaa 
            20                  25                  30          


Leu Val Xaa Xaa Xaa Xaa Cys Glu Asp Ile Asp Glu Cys Gln Xaa Pro 
        35                  40                  45              


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Xaa Xaa Lys Cys 
    50                  55                  60                  


Xaa Cys Xaa Xaa Gly Phe Xaa Xaa Asp Pro His Thr Xaa Xaa Cys Lys 
65                  70                  75                  80  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCSK9 Mammalian Consensus Sequence N-Terminal Sequence


<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Xaa = A,C,F,G,H,I,K,L,M,R,T,V,W,or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = A,C,D,G,N,P,S,T, or V

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A,C,D,E,G,H,K,N,Q,R,S,or T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa =A,C,F,G,H,I,K,L,M,R,T,V,W, or Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa =A,C,F,G,H,I,K,L,M,R,T,V,W, or Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Met Gly Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Trp Pro Leu Xaa 
1               5                   10                  


<210>  28
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Xaa = any

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa = A,C,D,G,N,P,S,T,or V

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa = A,C,D,G,N,P,S,T,or V

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa = A,G,or S

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa = A,C,D,E,G,H,K,N,Q,R,S,or T

<400>  28

Xaa Xaa Leu Leu Leu Leu Leu Leu Leu Xaa Pro Xaa Gly Xaa Xaa Ala 
1               5                   10                  15      


