                         SEQUENCE LISTING

<110>  Eutropics
 
<120>  METHOD FOR PREDICTING CANCER SENSITIVITY

<130>  EUTR-014/01WO

<150>  61/861,009
<151>  2013-08-01

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  2
<211>  233
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  3
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Asp Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  4
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Thr Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Thr Val Leu Thr Gly 
                165                 170                 175     


Ala Val Ala Leu Gly Ala Leu Val Thr Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         


Lys 
    


<210>  5
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      


Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          


Thr Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              


Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  


Asp Thr Ala Arg Thr Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Thr Ile Phe Ala Phe Glu 
                85                  90                  95      


Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         


Asp Thr Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             


Asn Thr Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Glu Asn Gly Phe 
    130                 135                 140                 


Val Lys Lys Phe Glu Pro Lys Ser Gly Trp Met Thr Phe Leu Glu Val 
145                 150                 155                 160 


Thr Gly Lys Ile Cys Glu Met Leu Ser Leu Leu Lys Gln Tyr Cys 
                165                 170                 175 


<210>  6
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         


<210>  7
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  8
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  9
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 


<210>  10
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Gly Lys Lys Ala Arg Lys Asn Ala Gln Pro Ser Pro Ala Arg 
1               5                   10                  15      


Ala Pro Ala Glu Leu Glu Val Glu Cys Ala Thr Gln Leu Arg Arg Phe 
            20                  25                  30          


Gly Asp Lys Leu Asn Phe Arg Gln Lys Leu Leu Asn Leu Ile Ser Lys 
        35                  40                  45              


Leu Phe Cys Ser Gly Thr 
    50                  


<210>  11
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Cys Pro Cys Pro Leu His Arg Gly Arg Gly Pro Pro Ala Val Cys 
1               5                   10                  15      


Ala Cys Ser Ala Gly Arg Leu Gly Leu Arg Ser Ser Ala Ala Gln Leu 
            20                  25                  30          


Thr Ala Ala Arg Leu Lys Ala Leu Gly Asp Glu Leu His Gln Arg Thr 
        35                  40                  45              


Met Trp Arg Arg Arg Ala Arg Ser Arg Arg Ala Pro Ala Pro Gly Ala 
    50                  55                  60                  


Leu Pro Thr Tyr Trp Pro Trp Leu Cys Ala Ala Ala Gln Val Ala Ala 
65                  70                  75                  80  


Leu Ala Ala Trp Leu Leu Gly Arg Arg Asn Leu 
                85                  90      


<210>  12
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Thr Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Thr His Cys Cys Gly Pro Gly Leu Gln Pro Thr Ser 
    50                  55                  60                  


Gln Glu Asp Lys Ala Thr Gln Thr Leu Ser Pro Ala Ser Pro Ser Gln 
65                  70                  75                  80  


Gly Val Met Leu Pro Cys Gly Val Thr Glu Glu Pro Gln Arg Leu Phe 
                85                  90                  95      


Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala 
            100                 105                 110         


Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln 
        115                 120                 125             


Ala Glu Val Gln Ile Ala Arg Lys Leu Gln Cys Ile Ala Asp Gln Phe 
    130                 135                 140                 


His Arg Leu His Val Gln Gln His Gln Gln Asn Gln Asn Arg Val Trp 
145                 150                 155                 160 


Trp Gln Ile Leu Leu Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu 
                165                 170                 175     


Asn Arg Asn Gly Ala Gly Pro Arg 
            180                 


<210>  13
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Gln Tyr Arg Thr Val Arg Ser Gly Leu Leu Pro Pro Arg Pro Val 
1               5                   10                  15      


Pro Ala Arg Arg Arg Pro Cys Leu Arg Leu Pro Pro Pro Ala Ala Ala 
            20                  25                  30          


Arg Trp Ala Phe Ser Leu Leu Pro Asn Arg Val Trp Ala Ser Ser Pro 
        35                  40                  45              


Arg Val Leu Val Thr Leu Asp Pro Gly Ala Glu Pro Trp His His Asp 
    50                  55                  60                  


Ser Glu Ala Glu Thr Leu Ser Trp Ser His Pro Gly Glu Met Glu Pro 
65                  70                  75                  80  


Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln Pro Glu Asp 
                85                  90                  95      


Gly Glu Pro Val Thr Gln Pro Gly Ser Leu Leu Ser Ala Asp Leu Phe 
            100                 105                 110         


Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln Leu Phe Pro 
        115                 120                 125             


Leu Thr His Cys Cys Gly Pro Gly Leu Arg Pro Thr Ser Gln Glu Asp 
    130                 135                 140                 


Lys Ala Thr Gln Thr Leu Ser Pro Ala Ser Pro Ser Gln Gly Val Met 
145                 150                 155                 160 


Leu Pro Cys Gly Val Thr Glu Glu Pro Gln Arg Leu Phe Tyr Gly Asn 
                165                 170                 175     


Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala Val Leu Pro 
            180                 185                 190         


Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln Ala Glu Val 
        195                 200                 205             


Gln Ile Ala Arg Lys Leu Gln Cys Ile Ala Asp Gln Phe His Arg Leu 
    210                 215                 220                 


His Val Gln Gln His Gln Gln Asn Gln Asn Arg Val Trp Trp Gln Ile 
225                 230                 235                 240 


Leu Leu Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu Asn Arg Asn 
                245                 250                 255     


Gly Ala Gly Pro Arg 
            260     


<210>  14
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly 
1               5                   10                  15      


Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro 
            20                  25                  30          


Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro 
        35                  40                  45              


Ala Ala Pro Thr Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Thr Ala 
    50                  55                  60                  


Pro Pro Ala Val Thr Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly 
65                  70                  75                  80  


Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser 
                85                  90                  95      


Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro 
            100                 105                 110         


Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val Arg Gly 
        115                 120                 125             


Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met 
    130                 135                 140                 


Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln 
145                 150                 155                 160 


Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met 
                165                 170                 175     


Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro 
            180                 185                 190         


Asn 
    


<210>  15
<211>  4374
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Val Asp Arg Thr Lys Leu Lys Lys Thr Pro Thr Glu Ala Pro 
1               5                   10                  15      


Ala Asp Cys Arg Ala Leu Ile Asp Lys Leu Lys Val Cys Asn Asp Glu 
            20                  25                  30          


Gln Leu Leu Leu Glu Leu Gln Gln Ile Lys Thr Trp Asn Ile Gly Lys 
        35                  40                  45              


Cys Glu Leu Tyr His Trp Val Asp Leu Leu Asp Arg Phe Asp Gly Ile 
    50                  55                  60                  


Leu Ala Asp Ala Gly Gln Thr Val Glu Asn Met Ser Trp Met Leu Val 
65                  70                  75                  80  


Cys Asp Arg Pro Glu Arg Glu Gln Leu Lys Met Leu Leu Leu Ala Val 
                85                  90                  95      


Leu Asn Phe Thr Ala Leu Leu Ile Glu Tyr Ser Phe Ser Arg His Leu 
            100                 105                 110         


Tyr Ser Ser Ile Glu His Leu Thr Thr Leu Leu Ala Ser Ser Asp Met 
        115                 120                 125             


Gln Val Val Leu Ala Val Leu Asn Leu Leu Tyr Val Phe Ser Lys Arg 
    130                 135                 140                 


Ser Asn Tyr Ile Thr Arg Leu Gly Ser Asp Lys Arg Thr Pro Leu Leu 
145                 150                 155                 160 


Thr Arg Leu Gln His Leu Ala Glu Ser Trp Gly Gly Lys Glu Asn Gly 
                165                 170                 175     


Phe Gly Leu Ala Glu Cys Cys Arg Asp Leu His Met Met Lys Tyr Pro 
            180                 185                 190         


Pro Ser Ala Thr Thr Leu His Phe Glu Phe Tyr Ala Asp Pro Gly Ala 
        195                 200                 205             


Glu Val Lys Ile Glu Lys Arg Thr Thr Ser Asn Thr Leu His Tyr Ile 
    210                 215                 220                 


His Ile Glu Gln Leu Asp Lys Ile Ser Glu Ser Pro Ser Glu Ile Met 
225                 230                 235                 240 


Glu Ser Leu Thr Lys Met Tyr Ser Ile Pro Lys Asp Lys Gln Met Leu 
                245                 250                 255     


Leu Phe Thr His Ile Arg Leu Ala His Gly Phe Ser Asn His Arg Lys 
            260                 265                 270         


Arg Leu Gln Ala Val Gln Ala Arg Leu His Ala Ile Ser Ile Leu Val 
        275                 280                 285             


Tyr Ser Asn Ala Leu Gln Glu Ser Ala Asn Ser Ile Leu Tyr Asn Gly 
    290                 295                 300                 


Leu Ile Glu Glu Leu Val Asp Val Leu Gln Ile Thr Asp Lys Gln Leu 
305                 310                 315                 320 


Met Glu Ile Lys Ala Ala Ser Leu Arg Thr Leu Thr Ser Ile Val His 
                325                 330                 335     


Leu Glu Arg Thr Pro Lys Leu Ser Ser Ile Ile Asp Cys Thr Gly Thr 
            340                 345                 350         


Ala Ser Tyr His Gly Phe Leu Pro Val Leu Val Arg Asn Cys Ile Gln 
        355                 360                 365             


Ala Met Ile Asp Pro Ser Met Asp Pro Tyr Pro His Gln Phe Ala Thr 
    370                 375                 380                 


Ala Leu Phe Ser Phe Leu Tyr His Leu Ala Ser Tyr Asp Ala Gly Gly 
385                 390                 395                 400 


Glu Ala Leu Val Ser Cys Gly Met Met Glu Ala Leu Leu Lys Val Ile 
                405                 410                 415     


Lys Phe Leu Gly Asp Glu Gln Asp Gln Ile Thr Phe Val Thr Arg Ala 
            420                 425                 430         


Val Arg Val Val Asp Leu Ile Thr Asn Leu Asp Met Ala Ala Phe Gln 
        435                 440                 445             


Ser His Ser Gly Leu Ser Ile Phe Ile Tyr Arg Leu Glu His Glu Val 
    450                 455                 460                 


Asp Leu Cys Arg Lys Glu Cys Pro Phe Val Ile Lys Pro Lys Ile Gln 
465                 470                 475                 480 


Arg Pro Asn Thr Thr Gln Glu Gly Glu Glu Met Glu Thr Asp Met Asp 
                485                 490                 495     


Gly Val Gln Cys Ile Pro Gln Arg Ala Ala Leu Leu Lys Ser Met Leu 
            500                 505                 510         


Asn Phe Leu Lys Lys Ala Ile Gln Asp Pro Ala Phe Ser Asp Gly Ile 
        515                 520                 525             


Arg His Val Met Asp Gly Ser Leu Pro Thr Ser Leu Lys His Ile Ile 
    530                 535                 540                 


Ser Asn Ala Glu Tyr Tyr Gly Pro Ser Leu Phe Leu Leu Ala Thr Glu 
545                 550                 555                 560 


Val Val Thr Val Phe Val Phe Gln Glu Pro Ser Leu Leu Ser Ser Leu 
                565                 570                 575     


Gln Asp Asn Gly Leu Thr Asp Val Met Leu His Ala Leu Leu Ile Lys 
            580                 585                 590         


Asp Val Pro Ala Thr Arg Glu Val Leu Gly Ser Leu Pro Asn Val Phe 
        595                 600                 605             


Ser Ala Leu Cys Leu Asn Ala Arg Gly Leu Gln Ser Phe Val Gln Cys 
    610                 615                 620                 


Gln Pro Phe Glu Arg Leu Phe Lys Val Leu Leu Ser Pro Asp Tyr Leu 
625                 630                 635                 640 


Pro Ala Met Arg Arg Arg Arg Ser Ser Asp Pro Leu Gly Asp Thr Ala 
                645                 650                 655     


Ser Asn Leu Gly Ser Ala Val Asp Glu Leu Met Arg His Gln Pro Thr 
            660                 665                 670         


Leu Lys Thr Asp Ala Thr Thr Ala Ile Ile Lys Leu Leu Glu Glu Ile 
        675                 680                 685             


Cys Asn Leu Gly Arg Asp Pro Lys Tyr Ile Cys Gln Lys Pro Ser Ile 
    690                 695                 700                 


Gln Lys Ala Asp Gly Thr Ala Thr Ala Pro Pro Pro Arg Ser Asn His 
705                 710                 715                 720 


Ala Ala Glu Glu Ala Ser Ser Glu Asp Glu Glu Glu Glu Glu Val Gln 
                725                 730                 735     


Ala Met Gln Ser Phe Asn Ser Thr Gln Gln Asn Glu Thr Glu Pro Asn 
            740                 745                 750         


Gln Gln Val Val Gly Thr Glu Glu Arg Ile Pro Ile Pro Leu Met Asp 
        755                 760                 765             


Tyr Ile Leu Asn Val Met Lys Phe Val Glu Ser Ile Leu Ser Asn Asn 
    770                 775                 780                 


Thr Thr Asp Asp His Cys Gln Glu Phe Val Asn Gln Lys Gly Leu Leu 
785                 790                 795                 800 


Pro Leu Val Thr Ile Leu Gly Leu Pro Asn Leu Pro Ile Asp Phe Pro 
                805                 810                 815     


Thr Ser Ala Ala Cys Gln Ala Val Ala Gly Val Cys Lys Ser Ile Leu 
            820                 825                 830         


Thr Leu Ser His Glu Pro Lys Val Leu Gln Glu Gly Leu Leu Gln Leu 
        835                 840                 845             


Asp Ser Ile Leu Ser Ser Leu Glu Pro Leu His Arg Pro Ile Glu Ser 
    850                 855                 860                 


Pro Gly Gly Ser Val Leu Leu Arg Glu Leu Ala Cys Ala Gly Asn Val 
865                 870                 875                 880 


Ala Asp Ala Thr Leu Ser Ala Gln Ala Thr Pro Leu Leu His Ala Leu 
                885                 890                 895     


Thr Ala Ala His Ala Tyr Ile Met Met Phe Val His Thr Cys Arg Val 
            900                 905                 910         


Gly Gln Ser Glu Ile Arg Ser Ile Ser Val Asn Gln Trp Gly Ser Gln 
        915                 920                 925             


Leu Gly Leu Ser Val Leu Ser Lys Leu Ser Gln Leu Tyr Cys Ser Leu 
    930                 935                 940                 


Val Trp Glu Ser Thr Val Leu Leu Ser Leu Cys Thr Pro Asn Ser Leu 
945                 950                 955                 960 


Pro Ser Gly Cys Glu Phe Gly Gln Ala Asp Met Gln Lys Leu Val Pro 
                965                 970                 975     


Lys Asp Glu Lys Ala Gly Thr Thr Gln Gly Gly Lys Arg Ser Asp Gly 
            980                 985                 990         


Glu Gln Asp Gly Ala Ala Gly Ser  Met Asp Ala Ser Thr  Gln Gly Leu 
        995                 1000                 1005             


Leu Glu  Gly Ile Gly Leu Asp  Gly Asp Thr Leu Ala  Pro Met Glu 
    1010                 1015                 1020             


Thr Asp  Glu Pro Thr Ala Ser  Asp Ser Lys Gly Lys  Ser Lys Ile 
    1025                 1030                 1035             


Thr Pro  Ala Met Ala Ala Arg  Ile Lys Gln Ile Lys  Pro Leu Leu 
    1040                 1045                 1050             


Ser Ala  Ser Ser Arg Leu Gly  Arg Ala Leu Ala Glu  Leu Phe Gly 
    1055                 1060                 1065             


Leu Leu  Val Lys Leu Cys Val  Gly Ser Pro Val Arg  Gln Arg Arg 
    1070                 1075                 1080             


Ser His  His Ala Ala Ser Thr  Thr Thr Ala Pro Thr  Pro Ala Ala 
    1085                 1090                 1095             


Arg Ser  Thr Ala Ser Ala Leu  Thr Lys Leu Leu Thr  Lys Gly Leu 
    1100                 1105                 1110             


Ser Trp  Gln Pro Pro Pro Tyr  Thr Pro Thr Pro Arg  Phe Arg Leu 
    1115                 1120                 1125             


Thr Phe  Phe Ile Cys Ser Val  Gly Phe Thr Ser Pro  Met Leu Phe 
    1130                 1135                 1140             


Asp Glu  Arg Lys Tyr Pro Tyr  His Leu Met Leu Gln  Lys Phe Leu 
    1145                 1150                 1155             


Cys Ser  Gly Gly His Asn Ala  Leu Phe Glu Thr Phe  Asn Trp Ala 
    1160                 1165                 1170             


Leu Ser  Met Gly Gly Lys Val  Pro Val Ser Glu Gly  Leu Glu His 
    1175                 1180                 1185             


Ser Asp  Leu Pro Asp Gly Thr  Gly Glu Phe Leu Asp  Ala Trp Leu 
    1190                 1195                 1200             


Met Leu  Val Glu Lys Met Val  Asn Pro Thr Thr Val  Leu Glu Ser 
    1205                 1210                 1215             


Pro His  Ser Leu Pro Ala Lys  Leu Pro Gly Gly Val  Gln Asn Phe 
    1220                 1225                 1230             


Pro Gln  Phe Ser Ala Leu Arg  Phe Leu Val Val Thr  Gln Lys Ala 
    1235                 1240                 1245             


Ala Phe  Thr Cys Ile Lys Asn  Leu Trp Asn Arg Lys  Pro Leu Lys 
    1250                 1255                 1260             


Val Tyr  Gly Gly Arg Met Ala  Glu Ser Met Leu Ala  Ile Leu Cys 
    1265                 1270                 1275             


His Ile  Leu Arg Gly Glu Pro  Val Ile Arg Glu Arg  Leu Ser Lys 
    1280                 1285                 1290             


Glu Lys  Glu Gly Ser Arg Gly  Glu Glu Asp Thr Gly  Gln Glu Glu 
    1295                 1300                 1305             


Gly Gly  Ser Arg Arg Glu Pro  Gln Val Asn Gln Gln  Gln Leu Gln 
    1310                 1315                 1320             


Gln Leu  Met Asp Met Gly Phe  Thr Arg Glu His Ala  Met Glu Ala 
    1325                 1330                 1335             


Leu Leu  Asn Thr Ser Thr Met  Glu Gln Ala Thr Glu  Tyr Leu Leu 
    1340                 1345                 1350             


Thr His  Pro Pro Pro Ile Met  Gly Gly Val Val Arg  Asp Leu Ser 
    1355                 1360                 1365             


Met Ser  Glu Glu Asp Gln Met  Met Arg Ala Ile Ala  Met Ser Leu 
    1370                 1375                 1380             


Gly Gln  Asp Ile Pro Met Asp  Gln Arg Ala Glu Ser  Pro Glu Glu 
    1385                 1390                 1395             


Val Ala  Cys Arg Lys Glu Glu  Glu Glu Arg Lys Ala  Arg Glu Lys 
    1400                 1405                 1410             


Gln Glu  Glu Glu Glu Ala Lys  Cys Leu Glu Lys Phe  Gln Asp Ala 
    1415                 1420                 1425             


Asp Pro  Leu Glu Gln Asp Glu  Leu His Thr Phe Thr  Asp Thr Met 
    1430                 1435                 1440             


Leu Pro  Gly Cys Phe His Leu  Leu Asp Glu Leu Pro  Asp Thr Val 
    1445                 1450                 1455             


Tyr Arg  Val Cys Asp Leu Ile  Met Thr Ala Ile Lys  Arg Asn Gly 
    1460                 1465                 1470             


Ala Asp  Tyr Arg Asp Met Ile  Leu Lys Gln Val Val  Asn Gln Val 
    1475                 1480                 1485             


Trp Glu  Ala Ala Asp Val Leu  Ile Lys Ala Ala Leu  Pro Leu Thr 
    1490                 1495                 1500             


Thr Ser  Asp Thr Lys Thr Val  Ser Glu Trp Ile Ser  Gln Met Ala 
    1505                 1510                 1515             


Thr Leu  Pro Gln Ala Ser Asn  Leu Ala Thr Arg Ile  Leu Leu Leu 
    1520                 1525                 1530             


Thr Leu  Leu Phe Glu Glu Leu  Lys Leu Pro Cys Ala  Trp Val Val 
    1535                 1540                 1545             


Glu Ser  Ser Gly Ile Leu Asn  Val Leu Ile Lys Leu  Leu Glu Val 
    1550                 1555                 1560             


Val Gln  Pro Cys Leu Gln Ala  Ala Lys Glu Gln Lys  Glu Val Gln 
    1565                 1570                 1575             


Thr Pro  Lys Trp Ile Thr Pro  Val Leu Leu Leu Ile  Asp Phe Tyr 
    1580                 1585                 1590             


Glu Lys  Thr Ala Ile Ser Ser  Lys Arg Arg Ala Gln  Met Thr Lys 
    1595                 1600                 1605             


Tyr Leu  Gln Ser Asn Ser Asn  Asn Trp Arg Trp Phe  Asp Asp Arg 
    1610                 1615                 1620             


Ser Gly  Arg Trp Cys Ser Tyr  Ser Ala Ser Asn Asn  Ser Thr Ile 
    1625                 1630                 1635             


Asp Ser  Ala Trp Lys Ser Gly  Glu Thr Ser Val Arg  Phe Thr Ala 
    1640                 1645                 1650             


Gly Arg  Arg Arg Tyr Thr Val  Gln Phe Thr Thr Met  Val Gln Val 
    1655                 1660                 1665             


Asn Glu  Glu Thr Gly Asn Arg  Arg Pro Val Met Leu  Thr Leu Leu 
    1670                 1675                 1680             


Arg Val  Pro Arg Leu Asn Lys  Asn Ser Lys Asn Ser  Asn Gly Gln 
    1685                 1690                 1695             


Glu Leu  Glu Lys Thr Leu Glu  Glu Ser Lys Glu Met  Asp Ile Lys 
    1700                 1705                 1710             


Arg Lys  Glu Asn Lys Gly Asn  Asp Thr Pro Leu Ala  Leu Glu Ser 
    1715                 1720                 1725             


Thr Asn  Thr Glu Lys Glu Thr  Ser Leu Glu Glu Thr  Lys Ile Gly 
    1730                 1735                 1740             


Glu Ile  Leu Ile Gln Gly Leu  Thr Glu Asp Met Val  Thr Val Leu 
    1745                 1750                 1755             


Ile Arg  Ala Cys Val Ser Met  Leu Gly Val Pro Val  Asp Pro Asp 
    1760                 1765                 1770             


Thr Leu  His Ala Thr Leu Arg  Leu Cys Leu Arg Leu  Thr Arg Asp 
    1775                 1780                 1785             


His Lys  Tyr Ala Met Met Phe  Ala Glu Leu Lys Ser  Thr Arg Met 
    1790                 1795                 1800             


Ile Leu  Asn Leu Thr Gln Ser  Ser Gly Phe Asn Gly  Phe Thr Pro 
    1805                 1810                 1815             


Leu Val  Thr Leu Leu Leu Arg  His Ile Ile Glu Asp  Pro Cys Thr 
    1820                 1825                 1830             


Leu Arg  His Thr Met Glu Lys  Val Val Arg Ser Ala  Ala Thr Ser 
    1835                 1840                 1845             


Gly Ala  Gly Ser Thr Thr Ser  Gly Val Val Ser Gly  Ser Leu Gly 
    1850                 1855                 1860             


Ser Arg  Glu Ile Asn Tyr Ile  Leu Arg Val Leu Gly  Pro Ala Ala 
    1865                 1870                 1875             


Cys Arg  Asn Pro Asp Ile Phe  Thr Glu Val Ala Asn  Cys Cys Ile 
    1880                 1885                 1890             


Arg Ile  Ala Leu Pro Ala Pro  Arg Gly Ser Gly Thr  Ala Ser Asp 
    1895                 1900                 1905             


Asp Glu  Phe Glu Asn Leu Arg  Ile Lys Gly Pro Asn  Ala Val Gln 
    1910                 1915                 1920             


Leu Val  Lys Thr Thr Pro Leu  Lys Pro Ser Pro Leu  Pro Val Ile 
    1925                 1930                 1935             


Pro Asp  Thr Ile Lys Glu Val  Ile Tyr Asp Met Leu  Asn Ala Leu 
    1940                 1945                 1950             


Ala Ala  Tyr His Ala Pro Glu  Glu Ala Asp Lys Ser  Asp Pro Lys 
    1955                 1960                 1965             


Pro Gly  Val Met Thr Gln Glu  Val Gly Gln Leu Leu  Gln Asp Met 
    1970                 1975                 1980             


Gly Asp  Asp Val Tyr Gln Gln  Tyr Arg Ser Leu Thr  Arg Gln Ser 
    1985                 1990                 1995             


Ser Asp  Phe Asp Thr Gln Ser  Gly Phe Ser Ile Asn  Ser Gln Val 
    2000                 2005                 2010             


Phe Ala  Ala Asp Gly Ala Ser  Thr Glu Thr Ser Ala  Ser Gly Thr 
    2015                 2020                 2025             


Ser Gln  Gly Glu Ala Ser Thr  Pro Glu Glu Ser Arg  Asp Gly Lys 
    2030                 2035                 2040             


Lys Asp  Lys Glu Gly Asp Arg  Ala Ser Glu Glu Gly  Lys Gln Lys 
    2045                 2050                 2055             


Gly Lys  Gly Ser Lys Pro Leu  Met Pro Thr Ser Thr  Ile Leu Arg 
    2060                 2065                 2070             


Leu Leu  Ala Glu Leu Val Arg  Ser Tyr Val Gly Ile  Ala Thr Leu 
    2075                 2080                 2085             


Ile Ala  Asn Tyr Ser Tyr Thr  Val Gly Gln Ser Glu  Leu Ile Lys 
    2090                 2095                 2100             


Glu Asp  Cys Ser Val Leu Ala  Phe Val Leu Asp His  Leu Leu Pro 
    2105                 2110                 2115             


His Thr  Gln Asn Ala Glu Asp  Lys Asp Thr Pro Ala  Leu Ala Arg 
    2120                 2125                 2130             


Leu Phe  Leu Ala Ser Leu Ala  Ala Ala Gly Ser Gly  Thr Asp Ala 
    2135                 2140                 2145             


Gln Val  Ala Leu Val Asn Glu  Val Lys Ala Ala Leu  Gly Arg Ala 
    2150                 2155                 2160             


Leu Ala  Met Ala Glu Ser Thr  Glu Lys His Ala Arg  Leu Gln Ala 
    2165                 2170                 2175             


Val Met  Cys Ile Ile Ser Thr  Ile Met Glu Ser Cys  Pro Ser Thr 
    2180                 2185                 2190             


Ser Ser  Phe Tyr Ser Ser Ala  Thr Ala Lys Thr Gln  His Asn Gly 
    2195                 2200                 2205             


Met Asn  Asn Ile Ile Arg Leu  Phe Leu Lys Lys Gly  Leu Val Asn 
    2210                 2215                 2220             


Asp Leu  Ala Arg Val Pro His  Ser Leu Asp Leu Ser  Ser Pro Asn 
    2225                 2230                 2235             


Met Ala  Asn Thr Val Asn Ala  Ala Leu Lys Pro Leu  Glu Thr Leu 
    2240                 2245                 2250             


Ser Arg  Ile Val Asn Gln Pro  Ser Ser Leu Phe Gly  Ser Lys Ser 
    2255                 2260                 2265             


Ala Ser  Ser Lys Asn Lys Ser  Glu Gln Asp Ala Gln  Gly Ala Ser 
    2270                 2275                 2280             


Gln Asp  Ser Ser Ser Asn Gln  Gln Asp Pro Gly Glu  Pro Gly Glu 
    2285                 2290                 2295             


Ala Glu  Val Gln Glu Glu Asp  His Asp Val Thr Gln  Thr Glu Val 
    2300                 2305                 2310             


Ala Asp  Gly Asp Ile Met Asp  Gly Glu Ala Glu Thr  Asp Ser Val 
    2315                 2320                 2325             


Val Ile  Ala Gly Gln Pro Glu  Val Leu Ser Ser Gln  Glu Met Gln 
    2330                 2335                 2340             


Val Glu  Asn Glu Leu Glu Asp  Leu Ile Asp Glu Leu  Leu Glu Arg 
    2345                 2350                 2355             


Asp Gly  Gly Ser Gly Asn Ser  Thr Ile Ile Val Ser  Arg Ser Gly 
    2360                 2365                 2370             


Glu Asp  Glu Ser Gln Glu Asp  Val Leu Met Asp Glu  Ala Pro Ser 
    2375                 2380                 2385             


Asn Leu  Ser Gln Ala Ser Thr  Leu Gln Ala Asn Arg  Glu Asp Ser 
    2390                 2395                 2400             


Met Asn  Ile Leu Asp Pro Glu  Asp Glu Glu Glu His  Thr Gln Glu 
    2405                 2410                 2415             


Glu Asp  Ser Ser Gly Ser Asn  Glu Asp Glu Asp Asp  Ser Gln Asp 
    2420                 2425                 2430             


Glu Glu  Glu Glu Glu Glu Glu  Asp Glu Glu Asp Asp  Gln Glu Asp 
    2435                 2440                 2445             


Asp Glu  Gly Glu Glu Gly Asp  Glu Asp Asp Asp Asp  Asp Gly Ser 
    2450                 2455                 2460             


Glu Met  Glu Leu Asp Glu Asp  Tyr Pro Asp Met Asn  Ala Ser Pro 
    2465                 2470                 2475             


Leu Val  Arg Phe Glu Arg Phe  Asp Arg Glu Asp Asp  Leu Ile Ile 
    2480                 2485                 2490             


Glu Phe  Asp Asn Met Phe Ser  Ser Ala Thr Asp Ile  Pro Pro Ser 
    2495                 2500                 2505             


Pro Gly  Asn Ile Pro Thr Thr  His Pro Leu Met Val  Arg His Ala 
    2510                 2515                 2520             


Asp His  Ser Ser Leu Thr Leu  Gly Ser Gly Ser Ser  Thr Thr Arg 
    2525                 2530                 2535             


Leu Thr  Gln Gly Ile Gly Arg  Ser Gln Arg Thr Leu  Arg Gln Leu 
    2540                 2545                 2550             


Thr Ala  Asn Thr Gly His Thr  Ile His Val His Tyr  Pro Gly Asn 
    2555                 2560                 2565             


Arg Gln  Pro Asn Pro Pro Leu  Ile Leu Gln Arg Leu  Leu Gly Pro 
    2570                 2575                 2580             


Ser Ala  Ala Ala Asp Ile Leu  Gln Leu Ser Ser Ser  Leu Pro Leu 
    2585                 2590                 2595             


Gln Ser  Arg Gly Arg Ala Arg  Leu Leu Val Gly Asn  Asp Asp Val 
    2600                 2605                 2610             


His Ile  Ile Ala Arg Ser Asp  Asp Glu Leu Leu Asp  Asp Phe Phe 
    2615                 2620                 2625             


His Asp  Gln Ser Thr Ala Thr  Ser Gln Ala Gly Thr  Leu Ser Ser 
    2630                 2635                 2640             


Ile Pro  Thr Ala Leu Thr Arg  Trp Thr Glu Glu Cys  Lys Val Leu 
    2645                 2650                 2655             


Asp Ala  Glu Ser Met His Asp  Cys Val Ser Val Val  Lys Val Ser 
    2660                 2665                 2670             


Ile Val  Asn His Leu Glu Phe  Leu Arg Asp Glu Glu  Leu Glu Glu 
    2675                 2680                 2685             


Arg Arg  Glu Lys Arg Arg Lys  Gln Leu Ala Glu Glu  Glu Thr Lys 
    2690                 2695                 2700             


Ile Thr  Asp Lys Gly Lys Glu  Asp Lys Glu Asn Arg  Asp Gln Ser 
    2705                 2710                 2715             


Ala Gln  Cys Thr Ala Ser Lys  Ser Asn Asp Ser Thr  Glu Gln Asn 
    2720                 2725                 2730             


Leu Ser  Asp Gly Thr Pro Met  Pro Asp Ser Tyr Pro  Thr Thr Pro 
    2735                 2740                 2745             


Ser Ser  Thr Asp Ala Ala Thr  Ser Glu Ser Lys Glu  Thr Leu Gly 
    2750                 2755                 2760             


Thr Leu  Gln Ser Ser Gln Gln  Gln Pro Thr Leu Pro  Thr Pro Pro 
    2765                 2770                 2775             


Ala Leu  Gly Glu Val Pro Gln  Glu Leu Gln Ser Pro  Ala Gly Glu 
    2780                 2785                 2790             


Gly Gly  Ser Ser Thr Gln Leu  Leu Met Pro Val Glu  Pro Glu Glu 
    2795                 2800                 2805             


Leu Gly  Pro Thr Arg Pro Ser  Gly Glu Ala Glu Thr  Thr Gln Met 
    2810                 2815                 2820             


Glu Leu  Ser Pro Ala Pro Thr  Ile Thr Ser Leu Ser  Pro Glu Arg 
    2825                 2830                 2835             


Ala Glu  Asp Ser Asp Ala Leu  Thr Ala Val Ser Ser  Gln Leu Glu 
    2840                 2845                 2850             


Gly Ser  Pro Met Asp Thr Ser  Ser Leu Ala Ser Cys  Thr Leu Glu 
    2855                 2860                 2865             


Glu Ala  Val Gly Asp Thr Ser  Ala Ala Gly Ser Ser  Glu Gln Pro 
    2870                 2875                 2880             


Arg Ala  Gly Ser Ser Thr Pro  Gly Asp Ala Pro Pro  Ala Val Ala 
    2885                 2890                 2895             


Glu Val  Gln Gly Arg Ser Asp  Gly Ser Gly Glu Ser  Ala Gln Pro 
    2900                 2905                 2910             


Pro Glu  Asp Ser Ser Pro Pro  Ala Ser Ser Glu Ser  Ser Ser Thr 
    2915                 2920                 2925             


Arg Asp  Ser Ala Val Ala Ile  Ser Gly Ala Asp Ser  Arg Gly Ile 
    2930                 2935                 2940             


Leu Glu  Glu Pro Leu Pro Ser  Thr Ser Ser Glu Glu  Glu Asp Pro 
    2945                 2950                 2955             


Leu Ala  Gly Ile Ser Leu Pro  Glu Gly Val Asp Pro  Ser Phe Leu 
    2960                 2965                 2970             


Ala Ala  Leu Pro Asp Asp Ile  Arg Arg Glu Val Leu  Gln Asn Gln 
    2975                 2980                 2985             


Leu Gly  Ile Arg Pro Pro Thr  Arg Thr Ala Pro Ser  Thr Asn Ser 
    2990                 2995                 3000             


Ser Ala  Pro Ala Val Val Gly  Asn Pro Gly Val Thr  Glu Val Ser 
    3005                 3010                 3015             


Pro Glu  Phe Leu Ala Ala Leu  Pro Pro Ala Ile Gln  Glu Glu Val 
    3020                 3025                 3030             


Leu Ala  Gln Gln Arg Ala Glu  Gln Gln Arg Arg Glu  Leu Ala Gln 
    3035                 3040                 3045             


Asn Ala  Ser Ser Asp Thr Pro  Met Asp Pro Val Thr  Phe Ile Gln 
    3050                 3055                 3060             


Thr Leu  Pro Ser Asp Leu Arg  Arg Ser Val Leu Glu  Asp Met Glu 
    3065                 3070                 3075             


Asp Ser  Val Leu Ala Val Met  Pro Pro Asp Ile Ala  Ala Glu Ala 
    3080                 3085                 3090             


Gln Ala  Leu Arg Arg Glu Gln  Glu Ala Arg Gln Arg  Gln Leu Met 
    3095                 3100                 3105             


His Glu  Arg Leu Phe Gly His  Ser Ser Thr Ser Ala  Leu Ser Ala 
    3110                 3115                 3120             


Ile Leu  Arg Ser Pro Ala Phe  Thr Ser Arg Leu Ser  Gly Asn Arg 
    3125                 3130                 3135             


Gly Val  Gln Tyr Thr Arg Leu  Ala Val Gln Arg Gly  Gly Thr Phe 
    3140                 3145                 3150             


Gln Met  Gly Gly Ser Ser Ser  His Asn Arg Pro Ser  Gly Ser Asn 
    3155                 3160                 3165             


Val Asp  Thr Leu Leu Arg Leu  Arg Gly Arg Leu Leu  Leu Asp His 
    3170                 3175                 3180             


Glu Ala  Leu Ser Cys Leu Leu  Val Leu Leu Phe Val  Asp Glu Pro 
    3185                 3190                 3195             


Lys Leu  Asn Thr Ser Arg Leu  His Arg Val Leu Arg  Asn Leu Cys 
    3200                 3205                 3210             


Tyr His  Ala Gln Thr Arg His  Trp Val Ile Arg Ser  Leu Leu Ser 
    3215                 3220                 3225             


Ile Leu  Gln Arg Ser Ser Glu  Ser Glu Leu Cys Ile  Glu Thr Pro 
    3230                 3235                 3240             


Lys Leu  Thr Thr Ser Glu Glu  Lys Gly Lys Lys Ser  Ser Lys Ser 
    3245                 3250                 3255             


Cys Gly  Ser Ser Ser His Glu  Asn Arg Pro Leu Asp  Leu Leu His 
    3260                 3265                 3270             


Lys Met  Glu Ser Lys Ser Ser  Asn Gln Leu Ser Trp  Leu Ser Val 
    3275                 3280                 3285             


Ser Met  Asp Ala Ala Leu Gly  Cys Arg Thr Asn Ile  Phe Gln Ile 
    3290                 3295                 3300             


Gln Arg  Ser Gly Gly Arg Lys  His Thr Glu Lys His  Ala Ser Gly 
    3305                 3310                 3315             


Gly Ser  Thr Val His Ile His  Pro Gln Ala Ala Pro  Val Val Cys 
    3320                 3325                 3330             


Arg His  Val Leu Asp Thr Leu  Ile Gln Leu Ala Lys  Val Phe Pro 
    3335                 3340                 3345             


Ser His  Phe Thr Gln Gln Arg  Thr Lys Glu Thr Asn  Cys Glu Ser 
    3350                 3355                 3360             


Asp Arg  Glu Arg Gly Asn Lys  Ala Cys Ser Pro Cys  Ser Ser Gln 
    3365                 3370                 3375             


Ser Ser  Ser Ser Gly Ile Cys  Thr Asp Phe Trp Asp  Leu Leu Val 
    3380                 3385                 3390             


Lys Leu  Asp Asn Met Asn Val  Ser Arg Lys Gly Lys  Asn Ser Val 
    3395                 3400                 3405             


Lys Ser  Val Pro Val Ser Ala  Gly Gly Glu Gly Glu  Thr Ser Pro 
    3410                 3415                 3420             


Tyr Ser  Leu Glu Ala Ser Pro  Leu Gly Gln Leu Met  Asn Met Leu 
    3425                 3430                 3435             


Ser His  Pro Val Ile Arg Arg  Ser Ser Leu Leu Thr  Glu Lys Leu 
    3440                 3445                 3450             


Leu Arg  Leu Leu Ser Leu Ile  Ser Ile Ala Leu Pro  Glu Asn Lys 
    3455                 3460                 3465             


Val Ser  Glu Ala Gln Ala Asn  Ser Gly Ser Gly Ala  Ser Ser Thr 
    3470                 3475                 3480             


Thr Thr  Ala Thr Ser Thr Thr  Ser Thr Thr Thr Thr  Thr Ala Ala 
    3485                 3490                 3495             


Ser Thr  Thr Pro Thr Pro Pro  Thr Ala Pro Thr Pro  Val Thr Ser 
    3500                 3505                 3510             


Ala Pro  Ala Leu Val Ala Ala  Thr Ala Ile Ser Thr  Ile Val Val 
    3515                 3520                 3525             


Ala Ala  Ser Thr Thr Val Thr  Thr Pro Thr Thr Ala  Thr Thr Thr 
    3530                 3535                 3540             


Val Ser  Ile Ser Pro Thr Thr  Lys Gly Ser Lys Ser  Pro Ala Lys 
    3545                 3550                 3555             


Val Ser  Asp Gly Gly Ser Ser  Ser Thr Asp Phe Lys  Met Val Ser 
    3560                 3565                 3570             


Ser Gly  Leu Thr Glu Asn Gln  Leu Gln Leu Ser Val  Glu Val Leu 
    3575                 3580                 3585             


Thr Ser  His Ser Cys Ser Glu  Glu Gly Leu Glu Asp  Ala Ala Asn 
    3590                 3595                 3600             


Val Leu  Leu Gln Leu Ser Arg  Gly Asp Ser Gly Thr  Arg Asp Thr 
    3605                 3610                 3615             


Val Leu  Lys Leu Leu Leu Asn  Gly Ala Arg His Leu  Gly Tyr Thr 
    3620                 3625                 3630             


Leu Cys  Lys Gln Ile Gly Thr  Leu Leu Ala Glu Leu  Arg Glu Tyr 
    3635                 3640                 3645             


Asn Leu  Glu Gln Gln Arg Arg  Ala Gln Cys Glu Thr  Leu Ser Pro 
    3650                 3655                 3660             


Asp Gly  Leu Pro Glu Glu Gln  Pro Gln Thr Thr Lys  Leu Lys Gly 
    3665                 3670                 3675             


Lys Met  Gln Ser Arg Phe Asp  Met Ala Glu Asn Val  Val Ile Val 
    3680                 3685                 3690             


Ala Ser  Gln Lys Arg Pro Leu  Gly Gly Arg Glu Leu  Gln Leu Pro 
    3695                 3700                 3705             


Ser Met  Ser Met Leu Thr Ser  Lys Thr Ser Thr Gln  Lys Phe Phe 
    3710                 3715                 3720             


Leu Arg  Val Leu Gln Val Ile  Ile Gln Leu Arg Asp  Asp Thr Arg 
    3725                 3730                 3735             


Arg Ala  Asn Lys Lys Ala Lys  Gln Thr Gly Arg Leu  Gly Ser Ser 
    3740                 3745                 3750             


Gly Leu  Gly Ser Ala Ser Ser  Ile Gln Ala Ala Val  Arg Gln Leu 
    3755                 3760                 3765             


Glu Ala  Glu Ala Asp Ala Ile  Ile Gln Met Val Arg  Glu Gly Gln 
    3770                 3775                 3780             


Arg Ala  Arg Arg Gln Gln Gln  Ala Ala Thr Ser Glu  Ser Ser Gln 
    3785                 3790                 3795             


Ser Glu  Ala Ser Val Arg Arg  Glu Glu Ser Pro Met  Asp Val Asp 
    3800                 3805                 3810             


Gln Pro  Ser Pro Ser Ala Gln  Asp Thr Gln Ser Ile  Ala Ser Asp 
    3815                 3820                 3825             


Gly Thr  Pro Gln Gly Glu Lys  Glu Lys Glu Glu Arg  Pro Pro Glu 
    3830                 3835                 3840             


Leu Pro  Leu Leu Ser Glu Gln  Leu Ser Leu Asp Glu  Leu Trp Asp 
    3845                 3850                 3855             


Met Leu  Gly Glu Cys Leu Lys  Glu Leu Glu Glu Ser  His Asp Gln 
    3860                 3865                 3870             


His Ala  Val Leu Val Leu Gln  Pro Ala Val Glu Ala  Phe Phe Leu 
    3875                 3880                 3885             


Val His  Ala Thr Glu Arg Glu  Ser Lys Pro Pro Val  Arg Asp Thr 
    3890                 3895                 3900             


Arg Glu  Ser Gln Leu Ala His  Ile Lys Asp Glu Pro  Pro Pro Leu 
    3905                 3910                 3915             


Ser Pro  Ala Pro Leu Thr Pro  Ala Thr Pro Ser Ser  Leu Asp Pro 
    3920                 3925                 3930             


Phe Phe  Ser Arg Glu Pro Ser  Ser Met His Ile Ser  Ser Ser Leu 
    3935                 3940                 3945             


Pro Pro  Asp Thr Gln Lys Phe  Leu Arg Phe Ala Glu  Thr His Arg 
    3950                 3955                 3960             


Thr Val  Leu Asn Gln Ile Leu  Arg Gln Ser Thr Thr  His Leu Ala 
    3965                 3970                 3975             


Asp Gly  Pro Phe Ala Val Leu  Val Asp Tyr Ile Arg  Val Leu Asp 
    3980                 3985                 3990             


Phe Asp  Val Lys Arg Lys Tyr  Phe Arg Gln Glu Leu  Glu Arg Leu 
    3995                 4000                 4005             


Asp Glu  Gly Leu Arg Lys Glu  Asp Met Ala Val His  Val Arg Arg 
    4010                 4015                 4020             


Asp His  Val Phe Glu Asp Ser  Tyr Arg Glu Leu His  Arg Lys Ser 
    4025                 4030                 4035             


Pro Glu  Glu Met Lys Asn Arg  Leu Tyr Ile Val Phe  Glu Gly Glu 
    4040                 4045                 4050             


Glu Gly  Gln Asp Ala Gly Gly  Leu Leu Arg Glu Trp  Tyr Met Ile 
    4055                 4060                 4065             


Ile Ser  Arg Glu Met Phe Asn  Pro Met Tyr Ala Leu  Phe Arg Thr 
    4070                 4075                 4080             


Ser Pro  Gly Asp Arg Val Thr  Tyr Thr Ile Asn Pro  Ser Ser His 
    4085                 4090                 4095             


Cys Asn  Pro Asn His Leu Ser  Tyr Phe Lys Phe Val  Gly Arg Ile 
    4100                 4105                 4110             


Val Ala  Lys Ala Val Tyr Asp  Asn Arg Leu Leu Glu  Cys Tyr Phe 
    4115                 4120                 4125             


Thr Arg  Ser Phe Tyr Lys His  Ile Leu Gly Lys Ser  Val Arg Tyr 
    4130                 4135                 4140             


Thr Asp  Met Glu Ser Glu Asp  Tyr His Phe Tyr Gln  Gly Leu Val 
    4145                 4150                 4155             


Tyr Leu  Leu Glu Asn Asp Val  Ser Thr Leu Gly Tyr  Asp Leu Thr 
    4160                 4165                 4170             


Phe Ser  Thr Glu Val Gln Glu  Phe Gly Val Cys Glu  Val Arg Asp 
    4175                 4180                 4185             


Leu Lys  Pro Asn Gly Ala Asn  Ile Leu Val Thr Glu  Glu Asn Lys 
    4190                 4195                 4200             


Lys Glu  Tyr Val His Leu Val  Cys Gln Met Arg Met  Thr Gly Ala 
    4205                 4210                 4215             


Ile Arg  Lys Gln Leu Ala Ala  Phe Leu Glu Gly Phe  Tyr Glu Ile 
    4220                 4225                 4230             


Ile Pro  Lys Arg Leu Ile Ser  Ile Phe Thr Glu Gln  Glu Leu Glu 
    4235                 4240                 4245             


Leu Leu  Ile Ser Gly Leu Pro  Thr Ile Asp Ile Asp  Asp Leu Lys 
    4250                 4255                 4260             


Ser Asn  Thr Glu Tyr His Lys  Tyr Gln Ser Asn Ser  Ile Gln Ile 
    4265                 4270                 4275             


Gln Trp  Phe Trp Arg Ala Leu  Arg Ser Phe Asp Gln  Ala Asp Arg 
    4280                 4285                 4290             


Ala Lys  Phe Leu Gln Phe Val  Thr Gly Thr Ser Lys  Val Pro Leu 
    4295                 4300                 4305             


Gln Gly  Phe Ala Ala Leu Glu  Gly Met Asn Gly Ile  Gln Lys Phe 
    4310                 4315                 4320             


Gln Ile  His Arg Asp Asp Arg  Ser Thr Asp Arg Leu  Pro Ser Ala 
    4325                 4330                 4335             


His Thr  Cys Phe Asn Gln Leu  Asp Leu Pro Ala Tyr  Glu Ser Phe 
    4340                 4345                 4350             


Glu Lys  Leu Arg His Met Leu  Leu Leu Ala Ile Gln  Glu Cys Ser 
    4355                 4360                 4365             


Glu Gly  Phe Gly Leu Ala 
    4370                 


<210>  16
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210>  17
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Thr Ser Leu Gln Thr Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Thr Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Thr Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Thr Gln Thr Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro 
    130                 135                 140                 


Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn 
145                 150                 155                 160 


Ala Tyr Tyr Ala Arg Arg Val Phe Leu Asn Asn Tyr Gln Ala Ala Glu 
                165                 170                 175     


Asp His Pro Arg Met Val Ile Leu Arg Leu Leu Arg Tyr Ile Val Arg 
            180                 185                 190         


Leu Val Trp Arg Met His 
        195             


<210>  18
<211>  8460
<212>  DNA
<213>  Homo sapiens

<400>  18
gctggggcca agccgcagag cggagttggc atttccagat tggggctcgg gccgcgcctc       60

ctccgggacc ctccccttgg accgagccga tcgccgcggg gcagttcggg ccggctgtcc      120

tggcgcgaaa aggtggacaa gtcctatttt caagagaaga tgacttttaa cagttttgaa      180

ggatctaaaa cttgtgtacc tgcagacatc aataaggaag aagaatttgt agaagagttt      240

aatagattaa aaacttttgc taattttcca agtggtagtc ctgtttcagc atcaacactg      300

gcacgagcag ggtttcttta tactggtgaa ggagataccg tgcggtgctt tagttgtcat      360

gcagctgtag atagatggca atatggagac tcagcagttg gaagacacag gaaagtatcc      420

ccaaattgca gatttatcaa cggcttttat cttgaaaata gtgccacgca gtctacaaat      480

tctggtatcc agaatggtca gtacaaagtt gaaaactatc tgggaagcag agatcatttt      540

gccttagaca ggccatctga gacacatgca gactatcttt tgagaactgg gcaggttgta      600

gatatatcag acaccatata cccgaggaac cctgccatgt atagtgaaga agctagatta      660

aagtcctttc agaactggcc agactatgct cacctaaccc caagagagtt agcaagtgct      720

ggactctact acacaggtat tggtgaccaa gtgcagtgct tttgttgtgg tggaaaactg      780

aaaaattggg aaccttgtga tcgtgcctgg tcagaacaca ggcgacactt tcctaattgc      840

ttctttgttt tgggccggaa tcttaatatt cgaagtgaat ctgatgctgt gagttctgat      900

aggaatttcc caaattcaac aaatcttcca agaaatccat ccatggcaga ttatgaagca      960

cggatcttta cttttgggac atggatatac tcagttaaca aggagcagct tgcaagagct     1020

ggattttatg ctttaggtga aggtgataaa gtaaagtgct ttcactgtgg aggagggcta     1080

actgattgga agcccagtga agacccttgg gaacaacatg ctaaatggta tccagggtgc     1140

aaatatctgt tagaacagaa gggacaagaa tatataaaca atattcattt aactcattca     1200

cttgaggagt gtctggtaag aactactgag aaaacaccat cactaactag aagaattgat     1260

gataccatct tccaaaatcc tatggtacaa gaagctatac gaatggggtt cagtttcaag     1320

gacattaaga aaataatgga ggaaaaaatt cagatatctg ggagcaacta taaatcactt     1380

gaggttctgg ttgcagatct agtgaatgct cagaaagaca gtatgcaaga tgagtcaagt     1440

cagacttcat tacagaaaga gattagtact gaagagcagc taaggcgcct gcaagaggag     1500

aagctttgca aaatctgtat ggatagaaat attgctatcg tttttgttcc ttgtggacat     1560

ctagtcactt gtaaacaatg tgctgaagca gttgacaagt gtcccatgtg ctacacagtc     1620

attactttca agcaaaaaat ttttatgtct taatctaact ctatagtagg catgttatgt     1680

tgttcttatt accctgattg aatgtgtgat gtgaactgac tttaagtaat caggattgaa     1740

ttccattagc atttgctacc aagtaggaaa aaaaatgtac atggcagtgt tttagttggc     1800

aatataatct ttgaatttct tgatttttca gggtattagc tgtattatcc atttttttta     1860

ctgttattta attgaaacca tagactaaga ataagaagca tcatactata actgaacaca     1920

atgtgtattc atagtatact gatttaattt ctaagtgtaa gtgaattaat catctggatt     1980

ttttattctt ttcagatagg cttaacaaat ggagctttct gtatataaat gtggagatta     2040

gagttaatct ccccaatcac ataatttgtt ttgtgtgaaa aaggaataaa ttgttccatg     2100

ctggtggaaa gatagagatt gtttttagag gttggttgtt gtgttttagg attctgtcca     2160

ttttctttta aagttataaa cacgtacttg tgcgaattat ttttttaaag tgatttgcca     2220

tttttgaaag cgtatttaat gatagaatac tatcgagcca acatgtactg acatggaaag     2280

atgtcaaaga tatgttaagt gtaaaatgca agtggcaaaa cactatgtat agtctgagcc     2340

agatcaaagt atgtatgttt ttaatatgca tagaacaaaa gatttggaaa gatatacacc     2400

aaactgttaa atgtggtttc tcttcgggga gggggggatt gggggagggg ccccagaggg     2460

gttttatagg ggccttttca ctttctactt ttttcatttt gttctgttcg aattttttat     2520

aagtatgtat tacttttgta atcagaattt ttagaaagta ttttgctgat ttaaaggctt     2580

aggcatgttc aaacgcctgc aaaactactt atcactcagc tttagttttt ctaatccaag     2640

aaggcagggc agttaacctt tttggtgcca atgtgaaatg taaatgattt tatgtttttc     2700

ctgctttgtg gatgaaaaat atttctgagt ggtagttttt tgacaggtag accatgtctt     2760

atcttgtttc aaaataagta tttctgattt tgtaaaatga aatataaaat atgtctcaga     2820

tcttccaatt aattagtaag gattcatcct taatccttgc tagtttaagc ctgcctaagt     2880

cactttacta aaagatcttt gttaactcag tattttaaac atctgtcagc ttatgtaggt     2940

aaaagtagaa gcatgtttgt acactgcttg tagttatagt gacagctttc catgttgaga     3000

ttctcatatc atcttgtatc ttaaagtttc atgtgagttt ttaccgttag gatgattaag     3060

atgtatatag gacaaaatgt taagtctttc ctctacctac atttgttttc ttggctagta     3120

atagtagtag atacttctga aataaatgtt ctctcaagat ccttaaaacc tcttggaaat     3180

tataaaaata ttggcaagaa aagaagaata gttgtttaaa tattttttaa aaaacacttg     3240

aataagaatc agtagggtat aaactagaag tttaaaaatg cttcatagaa cgtccagggt     3300

ttacattaca agattctcac aacaaaccta ttgtagaggt gagtaaggca tgttactaca     3360

gaggaaagtt tgagagtaaa actgtaaaaa attatatttt tgttgtactt tctaagagaa     3420

agagtattgt tatgttctcc taacttctgt tgattactac tttaagtgat attcatttaa     3480

aacattgcaa atttatttta tttatttaat tttctttttg agatggagtc ttgcttgtca     3540

cccaggctgg agtgcagtgg agtgatctct gctcactgca acctccgcct tctgggttca     3600

agcgattctc gtgcctcagc ttcctgagta gctggaatta caggcaggtg ccaccatgcc     3660

cgactaattt ttttttattt ttagtagaga cggggtttca ccatgttggc caggctggta     3720

tcaaactcct gacctcaaga gatccactcg ccttgccctc ccaaagtgct gggattacag     3780

gcttgagcca ccacgcccgg ctaaaacatt gcaaatttaa atgagagttt taaaaattaa     3840

ataatgactg ccctgtttct gttttagtat gtaaatcctc agttcttcac ctttgcactg     3900

tctgccactt agtttggtta tatagtcatt aacttgaatt tggtctgtat agtctagact     3960

ttaaatttaa agttttctac aaggggagaa aagtgttaaa atttttaaaa tatgttttcc     4020

aggacacttc acttccaagt caggtaggta gttcaatcta gttgttagcc aaggactcaa     4080

ggactgaatt gttttaacat aaggcttttc ctgttctggg agccgcactt cattaaaatt     4140

cttctaaaac ttgtatgttt agagttaagc aagacttttt ttcttcctct ccatgagttg     4200

tgaaatttaa tgcacaacgc tgatgtggct aacaagttta ttttaagaat tgtttagaaa     4260

tgctgttgct tcaggttctt aaaatcactc agcactccaa cttctaatca aatttttgga     4320

gacttaacag catttgtctg tgtttgaact ataaaaagca ccggatcttt tccatctaat     4380

tccgcaaaaa ttgatcattt gcaaagtcaa aactatagcc atatccaaat cttttccccc     4440

tcccaagagt tctcagtgtc tacatgtaga ctattccttt tctgtataaa gttcactcta     4500

ggatttcaag tcaccactta ttttacattt tagtcatgca aagattcaag tagttttgca     4560

ataagtactt atctttattt gtaataattt agtctgctga tcaaaagcat tgtcttaatt     4620

tttgagaact ggttttagca tttacaaact aaattccagt taattaatta atagctttat     4680

attgcctttc ctgctacatt tggttttttc ccctgtccct ttgattacgg gctaaggtag     4740

ggtagagtgg gtgtagtgag tgtatataat gtgatttggc cctgtgtatt atgatatttt     4800

gttatttttg ttgttatatt atttacattt cagtagttgt tttttgtgtt tccattttag     4860

tggataaaat ttgtattttg aactatgaat ggagactacc gccccagcat tagtttcaca     4920

tgatataccc tttaaacccg aatcattgtt ttatttcctg attacacagg tgttgaatgg     4980

ggaaaggggc tagtatatca gtaggatata ctatgggatg tatatatatc attgctgtta     5040

gagaaatgaa ataaaatggg gctgggctca gtggctcacg cctgtaatcc cagcactttg     5100

ggaggctgag gcaggtggat cacgaggtca ggagatcgag accatcctgg ctaacacggt     5160

gaaaccccgt ctctactaaa aaacagaaaa ttagccgggc gtggtggcgg gcgcctgtag     5220

tcccagctac tcgggaggct gaggcaggag aatggtgtga acccgggagg cagagcttgc     5280

agtgagccga gatctcgcca ctgcactcca gcctgggcaa cagagcaaga ctctgtctca     5340

aaaaaaaaaa aaaaagaaat aagaaaatgg gaagcaatat ttgacatagt tctttttagt     5400

caaatctact tgttaaaaaa agggtagcag tttattcatc tgtgaaagga aaataatact     5460

tatcttacaa ggttgcaaga gctcaaggag accatgtatg taaagttcct gctgtaaata     5520

tgaactccca tcctaatacc cttttacctc tctgtgggtt tgtcttgacc tggaaatttg     5580

ggctaaaact tagaaaaaat tcttacatga taactcagtg atgcttactc atagtttttg     5640

gtgtttctca tagataagat ataaatcagc tgggcgcggt ggctcatgcc tgtaatccca     5700

gcactttggg aggccgaggc gggcagatca cctgaggtcg ggaggtcgag accagcctga     5760

ccaacatgga gaaaccccgt ctctactaaa aatacaaaat tagctgggcg tggtggctca     5820

tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgaa cccaggaggc     5880

ggaggttgtg gtgagcgaag atcgtgccat tgcactccag cctgggcaac aagagcaaaa     5940

ctctgtctca aaaaaaaaaa aagatataaa tcacaataaa taaataggtc aatacaaatg     6000

ttagccaggc gtggtggcac atgcccatag tcgcagctac tctggaggca gaggcaggag     6060

gatcacttga gcccatgaat ttgaggcagc agtgagctat gattgtgcca ctgtactcca     6120

gtctgggtga cagagtgaga ccccatctct aaataaatag gtcaaaccct taaaaatatt     6180

taaattctta aaaaattgaa aagattattc ttctcaaatt tagttgagct ttctaagaga     6240

agcaattggc tttttcccac ttcaataatc attttcagtt tgactcatac agttaacaca     6300

atgtgaattt cttcctcagc ataacagagt tatagaatga cagggctgga agtgacctta     6360

gagagtatcc agttctttca ttttacaggt gaggcaactg agactcaaag gtgatgtaat     6420

ttgtgcaaag attatagcta attagtagca gagccctgac tgggacatag tttgaaggtg     6480

aaaaacttca ccaagctacc tttcttgaaa ggtccaaatg tttatgtttt caactactct     6540

ttccactgta ccataacttt cactacatat taaatgacac tttataacta atataatagg     6600

acaatcatca atgcatatat agccagccct tcatatctgt gggttttgca tccatggatt     6660

caaccaagga ggaattgaaa acactgagaa aaaaaaaaaa gaccacacaa taaaaaaaaa     6720

aaatacaaaa taatacaaag aaaaagccaa aattgtcata ctgttgttaa gcaacagtat     6780

aacaactatt tacatagcat taaggttggt gcaaaaatgc aaaaaaaaaa aaagcaatta     6840

tttttaaacc aacctaatat attgtattag gtattaaagt catctggaca tgaattaaag     6900

tatatgatgc cagcctggac aaaaggcaaa accctgtctc tacaaaaaat acaaaaatta     6960

gctgggcatg gtggtgtgtg cctgtagtcc tggctactcc ggagcctgag gtgggaggat     7020

cgcttgagtc tgggaggcag aggctgcatt gagctatgat catggcactg cattccagcc     7080

tgggtgacag tgcaagacct tgtctcagaa taaataaagt atgtgatgaa gatgtgcata     7140

cattatatgc aaatactgtt tttttttttt ttaatttaaa cagtctcact gtgttgccca     7200

ggatggagtg caatggcaca atcttggctc atggcaaact ctgcctcgca agcagctggg     7260

actacaggca tgctccacgg tgcccagtta attttttttg tattcttagt agagacaggg     7320

tttcaccatg ttggccaggc tagtcttgaa tttctgacct caagtgattc atctcccaaa     7380

gtgctgggat tacaggcgtg agccaccacg gccggctaat ttttgtattt tttagtagtg     7440

actggtttcg cggtgttgac caggctggtc tcgaactcct gatctcaggt gatctgcctg     7500

cctcggcctc acaaagtgct gggattacag gtgtgaacca ctgctcccgg ccttgtgtga     7560

ttttatctaa gggacttaag cgtcctcagg tcctaggggg tcgtgaaacc aaaaccccag     7620

ggatagcaag ggacaattgt atcttcaaag tagacaaatg gcgccgggca cggtggctca     7680

cgcctgtaat cccagcagtt tccgaggctg aggcaggcgg ctcacctgag gtcaggagtt     7740

ggagaccagc ctggccaaca tgctgaaacc ctgtctgtac aaaaatacaa aaatagctgg     7800

gcatggtggc gcatgcctgt agtcccagct actagagcga ctgaggcagg agaattgctt     7860

gaacctggga ggcggaggtt gcagggagcc aagatggcgc caccgcactc cagcctaggt     7920

gatagagtga gactccctct caaaaacaaa acaaaacaaa aaaattagac aaatgctaca     7980

ttaatgtttg ggtggtcaga ttctactttg aatctgaagt ttgcagatat gcctatagat     8040

ttttggagtt taccactttc ttattctgta tcattaatgt aatattttaa attactatat     8100

atgttaccat ttttctggat ttagtaagaa atttgcagtt ttggtttgat gtaacaaggg     8160

ttttaatgta atttatgtta gattttgcat ttttttcatt actgttatat tttaacctga     8220

ctgactgatc taattgtatt agtattgtga ataatcatgt gaaatgtttt gagacagagt     8280

actatatttg tgaatataat tttatggttt ttttcactta gaacctttct gtgtggaaaa     8340

ctaagaaaat tgctttctgc tgtataatct ggcattcatt gtagattaaa gcttattttt     8400

ctgtgaataa aacgtattca ataaaatact attctttaaa attatatcat aaaaaaaaaa     8460


<210>  19
<211>  3813
<212>  DNA
<213>  Homo sapiens

<400>  19
aacgctggtc ctcggccggg cgcgctgacg tcatcgtgcg tcagagtgag cccggatggg       60

gcggcgggct tcgggagcgc ccgggctgat ccgagccgag cgggccgtat ctccttgtcg      120

gcgccgctga ttcccggctc tgcggaggcc tctaggcagc cgcgcagctt ccgtgtttgc      180

tgcgcccgca ctgcgattta caaccctgaa gaatctccct atccctattt tgtccccctg      240

cagtaataaa tcccattatg gagatctcga aactttataa agggatatag tttgaattct      300

atggagtgta attttgtgta tgaattatat ttttaaaaca ttgaagagtt ttcagaaaga      360

aggctagtag agttgattac tgatacttta tgctaagcag tacttttttg gtagtacaat      420

attttgttag gcgtttctga taacactaga aaggacaagt tttatcttgt gataaattga      480

ttaatgttta caacatgact gataattata gctgaatagt ccttaaatga tgaacaggtt      540

atttagtttt taaatgcagt gtaaaaagtg tgctgtggaa attttatggc taactaagtt      600

tatggagaaa ataccttcag ttgatcaaga ataatagtgg tatacaaagt taggaagaaa      660

gtcaacatga tgctgcagga aatggaaaca aatacaaatg atatttaaca aagatagagt      720

ttacagtttt tgaactttaa gccaaattca tttgacatca agcactatag caggcacagg      780

ttcaacaaag cttgtgggta ttgacttccc ccaaaagttg tcagctgaag taatttagcc      840

cacttaagta aatactatga tgataagctg tgtgaactta gcttttaaat agtgtgacca      900

tatgaaggtt ttaattactt ttgtttattg gaataaaatg agattttttg ggttgtcatg      960

ttaaagtgct tatagggaaa gaagcctgca tataattttt taccttgtgg cataatcagt     1020

aattggtctg ttattcaggc ttcatagctt gtaaccaaat ataaataaaa ggcataattt     1080

aggtattcta tagttgctta gaattttgtt aatataaatc tctgtgaaaa atcaaggagt     1140

tttaatattt tcagaagtgc atccaccttt cagggcttta agttagtatt actcaagatt     1200

atgaacaaat agcacttagg ttacctgaaa gagttactac aaccccaaag agttgtgttc     1260

taagtagtat cttggtaatt cagagagata ctcatcctac ctgaatataa actgagataa     1320

atccagtaaa gaaagtgtag taaattctac ataagagtct atcattgatt tctttttgtg     1380

gtaaaaatct tagttcatgt gaagaaattt catgtgaatg ttttagctat caaacagtac     1440

tgtcacctac tcatgcacaa aactgcctcc caaagacttt tcccaggtcc ctcgtatcaa     1500

aacattaaga gtataatgga agatagcacg atcttgtcag attggacaaa cagcaacaaa     1560

caaaaaatga agtatgactt ttcctgtgaa ctctacagaa tgtctacata ttcaactttc     1620

cccgccgggg tgcctgtctc agaaaggagt cttgctcgtg ctggttttta ttatactggt     1680

gtgaatgaca aggtcaaatg cttctgttgt ggcctgatgc tggataactg gaaactagga     1740

gacagtccta ttcaaaagca taaacagcta tatcctagct gtagctttat tcagaatctg     1800

gtttcagcta gtctgggatc cacctctaag aatacgtctc caatgagaaa cagttttgca     1860

cattcattat ctcccacctt ggaacatagt agcttgttca gtggttctta ctccagcctt     1920

tctccaaacc ctcttaattc tagagcagtt gaagacatct cttcatcgag gactaacccc     1980

tacagttatg caatgagtac tgaagaagcc agatttctta cctaccatat gtggccatta     2040

acttttttgt caccatcaga attggcaaga gctggttttt attatatagg acctggagat     2100

agggtagcct gctttgcctg tggtgggaag ctcagtaact gggaaccaaa ggatgatgct     2160

atgtcagaac accggaggca ttttcccaac tgtccatttt tggaaaattc tctagaaact     2220

ctgaggttta gcatttcaaa tctgagcatg cagacacatg cagctcgaat gagaacattt     2280

atgtactggc catctagtgt tccagttcag cctgagcagc ttgcaagtgc tggtttttat     2340

tatgtgggtc gcaatgatga tgtcaaatgc ttttgttgtg atggtggctt gaggtgttgg     2400

gaatctggag atgatccatg ggtagaacat gccaagtggt ttccaaggtg tgagttcttg     2460

atacgaatga aaggccaaga gtttgttgat gagattcaag gtagatatcc tcatcttctt     2520

gaacagctgt tgtcaacttc agataccact ggagaagaaa atgctgaccc accaattatt     2580

cattttggac ctggagaaag ttcttcagaa gatgctgtca tgatgaatac acctgtggtt     2640

aaatctgcct tggaaatggg ctttaataga gacctggtga aacaaacagt tcaaagtaaa     2700

atcctgacaa ctggagagaa ctataaaaca gttaatgata ttgtgtcagc acttcttaat     2760

gctgaagatg aaaaaagaga agaggagaag gaaaaacaag ctgaagaaat ggcatcagat     2820

gatttgtcat taattcggaa gaacagaatg gctctctttc aacaattgac atgtgtgctt     2880

cctatcctgg ataatctttt aaaggccaat gtaattaata aacaggaaca tgatattatt     2940

aaacaaaaaa cacagatacc tttacaagcg agagaactga ttgataccat tttggttaaa     3000

ggaaatgctg cggccaacat cttcaaaaac tgtctaaaag aaattgactc tacattgtat     3060

aagaacttat ttgtggataa gaatatgaag tatattccaa cagaagatgt ttcaggtctg     3120

tcactggaag aacaattgag gaggttgcaa gaagaacgaa cttgtaaagt gtgtatggac     3180

aaagaagttt ctgttgtatt tattccttgt ggtcatctgg tagtatgcca ggaatgtgcc     3240

ccttctctaa gaaaatgccc tatttgcagg ggtataatca agggtactgt tcgtacattt     3300

ctctcttaaa gaaaaatagt ctatatttta acctgcataa aaaggtcttt aaaatattgt     3360

tgaacacttg aagccatcta aagtaaaaag ggaattatga gtttttcaat tagtaacatt     3420

catgttctag tctgctttgg tactaataat cttgtttctg aaaagatggt atcatatatt     3480

taatcttaat ctgtttattt acaagggaag atttatgttt ggtgaactat attagtatgt     3540

atgtgtacct aagggagtag tgtcactgct tgttatgcat catttcagga gttactggat     3600

ttgttgttct ttcagaaagc tttgaatact aaattatagt gtagaaaaga actggaaacc     3660

aggaactctg gagttcatca gagttatggt gccgaattgt ctttggtgct tttcacttgt     3720

gttttaaaat aaggattttt ctcttatttc tccccctagt ttgtgagaaa catctcaata     3780

aagtgcttta aaaagaaaaa aaaaaaaaaa aaa                                  3813


<210>  20
<211>  6932
<212>  DNA
<213>  Homo sapiens

<400>  20
gcatttaaaa gacagcgtga gactcgcgcc ctccggcacg gaaaaggcca ggcgacaggt       60

gtcgcttgaa aagactgggc ttgtccttgc tggtgcatgc gtcgtcggcc tctgggcagc      120

aggtttacaa aggaggaaaa cgacttcttc tagatttttt tttcagtttc ttctataaat      180

caaaacatct caaaatggag acctaaaatc cttaaaggga cttagtctaa tctcgggagg      240

tagttttgtg catgggtaaa caaattaagt attaactggt gttttactat ccaaagaatg      300

ctaattttat aaacatgatc gagttatata aggtatacca taatgagttt gattttgaat      360

ttgatttgtg gaaataaagg aaaagtgatt ctagctgggg catattgtta aagcattttt      420

ttcagagttg gccaggcagt ctcctactgg cacattctcc cattatgtag aatagaaata      480

gtacctgtgt ttgggaaaga ttttaaaatg agtgacagtt atttggaaca aagagctaat      540

aatcaatcca ctgcaaatta aagaaacatg cagatgaaag ttttgacaca ttaaaatact      600

tctacagtga caaagaaaaa tcaagaacaa agctttttga tatgtgcaac aaatttagag      660

gaagtaaaaa gataaatgtg atgattggtc aagaaattat ccagttattt acaaggccac      720

tgatatttta aacgtccaaa agtttgttta aatgggctgt taccgctgag aatgatgagg      780

atgagaatga tggttgaagg ttacatttta ggaaatgaag aaacttagaa aattaatata      840

aagacagtga tgaatacaaa gaagattttt ataacaatgt gtaaaatttt tggccaggga      900

aaggaatatt gaagttagat acaattactt acctttgagg gaaataattg ttggtaatga      960

gatgtgatgt ttctcctgcc acctggaaac aaagcattga agtctgcagt tgaaaagccc     1020

aacgtctgtg agatccagga aaccatgctt gcaaaccact ggtaaaaaaa aaaaaaaaaa     1080

aaaaaaaaag ccacagtgac ttgcttattg gtcattgcta gtattatcga ctcagaacct     1140

ctttactaat ggctagtaaa tcataattga gaaattctga attttgacaa ggtctctgct     1200

gttgaaatgg taaatttatt attttttttg tcatgataaa ttctggttca aggtatgcta     1260

tccatgaaat aatttctgac caaaactaaa ttgatgcaat ttgattatcc atcttagcct     1320

acagatggca tctggtaact tttgactgtt ttaaaaaata aatccactat cagagtagat     1380

ttgatgttgg cttcagaaac atttagaaaa acaaaagttc aaaaatgttt tcaggaggtg     1440

ataagttgaa taactctaca atgttagttc tttgaggggg acaaaaaatt taaaatcttt     1500

gaaaggtctt attttacagc catatctaaa ttatcttaag aaaattttta acaaagggaa     1560

tgaaatatat atcatgattc tgtttttcca aaagtaacct gaatatagca atgaagttca     1620

gttttgttat tggtagtttg ggcagagtct ctttttgcag cacctgttgt ctaccataat     1680

tacagaggac atttccatgt tctagccaag tatactatta gaataaaaaa acttaacatt     1740

gagttgcttc aacagcatga aactgagtcc aaaagaccaa atgaacaaac acattaatct     1800

ctgattattt attttaaata gaatatttaa ttgtgtaaga tctaatagta tcattatact     1860

taagcaatca tattcctgat gatctatggg aaataactat tatttaatta atattgaaac     1920

caggttttaa gatgtgttag ccagtcctgt tactagtaaa tctctttatt tggagagaaa     1980

ttttagattg ttttgttctc cttattagaa ggattgtaga aagaaaaaaa tgactaattg     2040

gagaaaaatt ggggatatat catatttcac tgaattcaaa atgtcttcag ttgtaaatct     2100

taccattatt ttacgtacct ctaagaaata aaagtgcttc taattaaaat atgatgtcat     2160

taattatgaa atacttcttg ataacagaag ttttaaaata gccatcttag aatcagtgaa     2220

atatggtaat gtattatttt cctcctttga gttaggtctt gtgctttttt ttcctggcca     2280

ctaaatttca caatttccaa aaagcaaaat aaacatattc tgaatatttt tgctgtgaaa     2340

cacttgacag cagagctttc caccatgaaa agaagcttca tgagtcacac attacatctt     2400

tgggttgatt gaatgccact gaaacattct agtagcctgg agaagttgac ctacctgtgg     2460

agatgcctgc cattaaatgg catcctgatg gcttaataca catcactctt ctgtgaaggg     2520

ttttaatttt caacacagct tactctgtag catcatgttt acattgtatg tataaagatt     2580

atacaaaggt gcaattgtgt atttcttcct taaaatgtat cagtatagga tttagaatct     2640

ccatgttgaa actctaaatg catagaaata aaaataataa aaaatttttc attttggctt     2700

ttcagcctag tattaaaact gataaaagca aagccatgca caaaactacc tccctagaga     2760

aaggctagtc ccttttcttc cccattcatt tcattatgaa catagtagaa aacagcatat     2820

tcttatcaaa tttgatgaaa agcgccaaca cgtttgaact gaaatacgac ttgtcatgtg     2880

aactgtaccg aatgtctacg tattccactt ttcctgctgg ggttcctgtc tcagaaagga     2940

gtcttgctcg tgctggtttc tattacactg gtgtgaatga caaggtcaaa tgcttctgtt     3000

gtggcctgat gctggataac tggaaaagag gagacagtcc tactgaaaag cataaaaagt     3060

tgtatcctag ctgcagattc gttcagagtc taaattccgt taacaacttg gaagctacct     3120

ctcagcctac ttttccttct tcagtaacaa attccacaca ctcattactt ccgggtacag     3180

aaaacagtgg atatttccgt ggctcttatt caaactctcc atcaaatcct gtaaactcca     3240

gagcaaatca agatttttct gccttgatga gaagttccta ccactgtgca atgaataacg     3300

aaaatgccag attacttact tttcagacat ggccattgac ttttctgtcg ccaacagatc     3360

tggcaaaagc aggcttttac tacataggac ctggagacag agtggcttgc tttgcctgtg     3420

gtggaaaatt gagcaattgg gaaccgaagg ataatgctat gtcagaacac ctgagacatt     3480

ttcccaaatg cccatttata gaaaatcagc ttcaagacac ttcaagatac acagtttcta     3540

atctgagcat gcagacacat gcagcccgct ttaaaacatt ctttaactgg ccctctagtg     3600

ttctagttaa tcctgagcag cttgcaagtg cgggttttta ttatgtgggt aacagtgatg     3660

atgtcaaatg cttttgctgt gatggtggac tcaggtgttg ggaatctgga gatgatccat     3720

gggttcaaca tgccaagtgg tttccaaggt gtgagtactt gataagaatt aaaggacagg     3780

agttcatccg tcaagttcaa gccagttacc ctcatctact tgaacagctg ctatccacat     3840

cagacagccc aggagatgaa aatgcagagt catcaattat ccattttgaa cctggagaag     3900

accattcaga agatgcaatc atgatgaata ctcctgtgat taatgctgcc gtggaaatgg     3960

gctttagtag aagcctggta aaacagacag ttcagagaaa aatcctagca actggagaga     4020

attatagact agtcaatgat cttgtgttag acttactcaa tgcagaagat gaaataaggg     4080

aagaggagag agaaagagca actgaggaaa aagaatcaaa tgatttatta ttaatccgga     4140

agaatagaat ggcacttttt caacatttga cttgtgtaat tccaatcctg gatagtctac     4200

taactgccgg aattattaat gaacaagaac atgatgttat taaacagaag acacagacgt     4260

ctttacaagc aagagaactg attgatacga ttttagtaaa aggaaatatt gcagccactg     4320

tattcagaaa ctctctgcaa gaagctgaag ctgtgttata tgagcattta tttgtgcaac     4380

aggacataaa atatattccc acagaagatg tttcagatct accagtggaa gaacaattgc     4440

ggagactaca agaagaaaga acatgtaaag tgtgtatgga caaagaagtg tccatagtgt     4500

ttattccttg tggtcatcta gtagtatgca aagattgtgc tccttcttta agaaagtgtc     4560

ctatttgtag gagtacaatc aagggtacag ttcgtacatt tctttcatga agaagaacca     4620

aaacatcgtc taaactttag aattaattta ttaaatgtat tataacttta acttttatcc     4680

taatttggtt tccttaaaat ttttatttat ttacaactca aaaaacattg ttttgtgtaa     4740

catatttata tatgtatcta aaccatatga acatatattt tttagaaact aagagaatga     4800

taggcttttg ttcttatgaa cgaaaaagag gtagcactac aaacacaata ttcaatcaaa     4860

atttcagcat tattgaaatt gtaagtgaag taaaacttaa gatatttgag ttaaccttta     4920

agaattttaa atattttggc attgtactaa taccgggaac atgaagccag gtgtggtggt     4980

atgtgcctgt agtcccaggc tgaggcaaga gaattacttg agcccaggag tttgaatcca     5040

tcctgggcag catactgaga ccctgccttt aaaaacaaac agaacaaaaa caaaacacca     5100

gggacacatt tctctgtctt ttttgatcag tgtcctatac atcgaaggtg tgcatatatg     5160

ttgaatgaca ttttagggac atggtgtttt tataaagaat tctgtgagaa aaaatttaat     5220

aaagcaacaa aaattactct tattcttcat tgctttattt caatgacatt ggatagttta     5280

gtcactccca gactctttcc ataccttctt aaagcctctc aaatattgaa ctacagttta     5340

tactccttcc cataagatgc ttcttcattg acacttgtag aacacggggt caacacatca     5400

taaaatctat tatggaatgc ctgagacaag aatcaaacag tccctttagt aagtttgttt     5460

attcacttct ctattgattc attcaagaag tctcatgcca gccccaccta ttggaagaag     5520

gtctgagttt tattcttatc tctttggtat taattctgaa acttagaaag tacactggtt     5580

agcaatgctt gggaccaaca ggttgttctg gtaaataaat ctgtttcata ttgtcagtgc     5640

aacaaaatgt ccccctctgc attatgttat tggtactcaa cacgtccgag tcataactct     5700

gtcctttgct tcttatagag gtattaggtc ttcaagagca gaagtaagac tgtaataggg     5760

aatactcagg ggaaggcagg caaaggctag tcatctaaac cagttctaga tgtctgtata     5820

ggggcagatg gctctgtaag ggcagaaggg aaagacccct tcataagggt cacagctgac     5880

aatcctataa caaaagacag gttaacaaga gaaaaactta acaaatttat ttaatcacag     5940

atttacatca ccggggagcc ttcgtaatga agatccaaaa ttacagggga aactgtgcat     6000

ttttatgctt aggtttgata atgaatggac agccctgaag aatagtgatt ggaaaaaaag     6060

gatatgatct aatgggaata gacacaggtt ggggacccag caaggcctgt ctgttcagat     6120

tattcttggt ctctgtgcag cattccttcc tcctggatat agggcagggc ctgtatggga     6180

tggggatatt ataacctgct atcaagcaag gtaggtcaga gaatttattt atggccagct     6240

cttacatagt taggtgagga aagattagag tactatcttt aagatgtaag tctggcattg     6300

tggaaagatg gttccagttt ctatgaccta ccttggggaa gaggaattca agtttctgtg     6360

gcttgccttc agggagaatg aggctgagac aggagggcag gataacatca gagaaaaact     6420

ttgcttctga ggccttcact ttgggttttc tgagccccaa catctgctag tgttgtaaag     6480

agaacaatta gggaccaagt gaggggagga aagaatccat ctctgcattc tgatgctggg     6540

agacttattt ccttgaaatg caattgattt tgcctctgct aagaggctct gctggctacc     6600

catgtactag ccagtgtcct gcatgggtgc taggctgaat tatttgtaat tgtgcttagg     6660

tgatttgtaa ctcaggtata gggtatttaa atagtaggca ccctttttgc accatgtgtt     6720

ttttttttta tctagttctt gtatactaca gataatattt gaactttgtc atctcactgt     6780

aaaacttttg ttcatttctc attatggtaa taaatagcta ttataaccaa cccatttatt     6840

caaatatgtt atttccctaa gtgttatttt gacattttgt tttggaaaaa ataaatcacc     6900

atagataata aaaaaaaaaa aaaaaaaaaa aa                                   6932


<210>  21
<211>  14796
<212>  DNA
<213>  Homo sapiens

<400>  21
tctagacatg cggatatatt caagctgggc acagcacagc agccccaccc caggcagctt       60

gaaatcagag ctggggtcca aagggaccac accccgaggg actgtgtggg ggtcggggca      120

cacaggccac tgcttccccc cgtctttctc agccattcct gaagtcagcc tcactctgct      180

tctcagggat ttcaaatgtg cagagactct ggcacttttg tagaagcccc ttctggtcct      240

aacttacacc tggatgctgt ggggctgcag ctgctgctcg ggctcgggag gatgctgggg      300

gcccggtgcc catgagcttt tgaagctcct ggaactcggt tttgagggtg ttcaggtcca      360

ggtggacacc tgggctgtcc ttgtccatgc atttgatgac attgtgtgca gaagtgaaaa      420

ggagttaggc cgggcatgct ggcttatgcc tgtaatccca gcactttggg aggctgaggc      480

gggtggatca cgaggtcagg agttcaatac cagcctggcc aagatggtga aaccccgtct      540

ctactaaaaa tacaaaaaaa ttagccgggc atggtggcgg gcgcatgtaa tcccagctac      600

tgggggggct gaggcagaga attgctggaa cccaggagat ggaggttgca gtgagccaag      660

attgtgccac tgcactgcac tccagcctgg cgacagagca agactctgtc tcaaaaaaaa      720

aaaaaaaaag tgaaaaggag ttgttccttt cctccctcct gagggcaggc aactgctgcg      780

gttgccagtg gaggtggtgc gtccttggtc tgtgcctggg ggccacccca gcagaggcca      840

tggtggtgcc agggcccggt tagcgagcca atcagcagga cccaggggcg acctgccaaa      900

gtcaactgga tttgataact gcagcgaagt taagtttcct gattttgatg attgtgttgt      960

ggttgtgtaa gagaatgaag tatttcgggg tagtatggta atgccttcaa cttacaaacg     1020

gttcaggtaa accacccata tacatacata tacatgcatg tgatatatac acatacaggg     1080

atgtgtgtgt gttcacatat atgaggggag agagactagg ggagagaaag taggttgggg     1140

agagggagag agaaaggaaa acaggagaca gagagagagc ggggagtaga gagagggaag     1200

gggtaagaga gggagaggag gagagaaagg gaggaagaag cagagagtga atgttaaagg     1260

aaacaggcaa aacataaaca gaaaatctgg gtgaagggta tatgagtatt ctttgtacta     1320

ttcttgcaat tatcttttat ttaaattgac atcgggccgg gcgcagtggc tcacatctgt     1380

aatcccagca ctttgggagg ccgaggcagg cagatcactt gaggtcagga gtttgagacc     1440

agcctggcaa acatggtgaa accccatctc tactaaaaat acaaaaatta gcctggtgtg     1500

gtggtgcatg cctttaatct cagctactcg ggaggctgag gcaggagaat cgcttgaacc     1560

cgtggcgggg aggaggttgc agtgagctga gatcatgcca ctgcactcca gcctgggcga     1620

tagagcgaga ctcagtttca aataaataaa taaacatcaa aataaaaagt tactgtatta     1680

aagaatgggg gcggggtggg aggggtgggg agaggttgca aaaataaata aataaataaa     1740

taaaccccaa aatgaaaaag acagtggagg caccaggcct gcgtggggct ggagggctaa     1800

taaggccagg cctcttatct ctggccatag aaccagagaa gtgagtggat gtgatgccca     1860

gctccagaag tgactccaga acaccctgtt ccaaagcaga ggacacactg attttttttt     1920

taataggctg caggacttac tgttggtggg acgccctgct ttgcgaaggg aaaggaggag     1980

tttgccctga gcacaggccc ccaccctcca ctgggctttc cccagctccc ttgtcttctt     2040

atcacggtag tggcccagtc cctggcccct gactccagaa ggtggccctc ctggaaaccc     2100

aggtcgtgca gtcaacgatg tactcgccgg gacagcgatg tctgctgcac tccatccctc     2160

ccctgttcat ttgtccttca tgcccgtctg gagtagatgc tttttgcaga ggtggcaccc     2220

tgtaaagctc tcctgtctga cttttttttt ttttttagac tgagttttgc tcttgttgcc     2280

taggctggag tgcaatggca caatctcagc tcactgcacc ctctgcctcc cgggttcaag     2340

cgattctcct gcctcagcct cccgagtagt tgggattaca ggcatgcacc accacgccca     2400

gctaattttt gtatttttag tagagacaag gtttcaccgt gatggccagg ctggtcttga     2460

actccaggac tcaagtgatg ctcctgccta ggcctctcaa agtgttggga ttacaggcgt     2520

gagccactgc acccggcctg cacgcgttct ttgaaagcag tcgagggggc gctaggtgtg     2580

ggcagggacg agctggcgcg gcgtcgctgg gtgcaccgcg accacgggca gagccacgcg     2640

gcgggaggac tacaactccc ggcacacccc gcgccgcccc gcctctactc ccagaaggcc     2700

gcggggggtg gaccgcctaa gagggcgtgc gctcccgaca tgccccgcgg cgcgccatta     2760

accgccagat ttgaatcgcg ggacccgttg gcagaggtgg cggcggcggc atgggtgccc     2820

cgacgttgcc ccctgcctgg cagccctttc tcaaggacca ccgcatctct acattcaaga     2880

actggccctt cttggagggc tgcgcctgca ccccggagcg ggtgagactg cccggcctcc     2940

tggggtcccc cacgcccgcc ttgccctgtc cctagcgagg ccactgtgac tgggcctcgg     3000

gggtacaagc cgccctcccc tccccgtcct gtccccagcg aggccactgt ggctgggccc     3060

cttgggtcca ggccggcctc ccctccctgc tttgtcccca tcgaggcctt tgtggctggg     3120

cctcggggtt ccgggctgcc acgtccactc acgagctgtg ctgtcccttg cagatggccg     3180

aggctggctt catccactgc cccactgaga acgagccaga cttggcccag tgtttcttct     3240

gcttcaagga gctggaaggc tgggagccag atgacgaccc catgtaagtc ttctctggcc     3300

agcctcgatg ggctttgttt tgaactgagt tgtcaaaaga tttgagttgc aaagacactt     3360

agtatgggag ggttgctttc caccctcatt gcttcttaaa cagctgttgt gaacggatac     3420

ctctctatat gctggtgcct tggtgatgct tacaacctaa ttaaatctca tttgaccaaa     3480

atgccttggg gtggacgtaa gatgcctgat gcctttcatg ttcaacagaa tacatcagca     3540

gaccctgttg ttgtgaactc ccaggaatgt ccaagtgctt tttttgagat tttttaaaaa     3600

acagtttaat tgaaatataa cctacacagc acaaaaatta ccctttgaaa gtgtgcactt     3660

cacactttcg gaggctgagg cgggcggatc acctgaggtc aggagttcaa gacctgcctg     3720

gccaacttgg cgaaaccccg tctctactaa aaatacaaaa attagccggg catggtagcg     3780

cacgcccgta atcccagcta ctcgggaggc taaggcagga gaatcgcttg aacctgggag     3840

gcggaggttg cagtgagccg agattgtgcc aatgcactcc agcctcggcg acagagcgag     3900

actccgtcat aaaaataaaa aattgaaaaa aaaaaaagaa agaaagcata tacttcagtg     3960

ttgttctgga tttttttctt caagatgcct agttaatgac aatgaaattc tgtactcgga     4020

tggtatctgt ctttccacac tgtaatgcca tattcttttc tcaccttttt ttctgtcgga     4080

ttcagttgct tccacagctt taattttttt cccctggaga atcaccccag ttgtttttct     4140

ttttggccag aagagagtag ctgttttttt tcttagtatg tttgctatgg tggttatact     4200

gcatccccgt aatcactggg aaaagatcag tggtattctt cttgaaaatg aataagtgtt     4260

atgatatttt cagattagag ttacaactgg ctgtcttttt ggactttgtg tggccatgtt     4320

ttcattgtaa tgcagttctg gtaacggtga tagtcagtta tacagggaga ctcccctagc     4380

agaaaatgag agtgtgagct agggggtccc ttggggaacc cggggcaata atgcccttct     4440

ctgcccttaa tccttacagt gggccgggca cggtggctta cgcctgtaat accagcactt     4500

tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaccatctt ggctaatacg     4560

gtgaaacccc gtctccacta aaaatacaaa aaattagccg ggcgtggtgg tgggcgcctg     4620

tagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacccagg aggcggagct     4680

tgcagtgagc cgagattgca ccactgcact ccagcctggg cgacagaatg agactccgtc     4740

tcaaaaaaaa aaaaaaaaga aaaaaatctt tacagtggat tacataacaa ttccagtgaa     4800

atgaaattac ttcaaacagt tccttgagaa tgttggaggg atttgacatg taattccttt     4860

ggacatatac catgtaacac ttttccaact aattgctaag gaagtccaga taaaatagat     4920

acattagcca cacagatgtg gggggagatg tccacaggga gagagaaggt gctaagaggt     4980

gccatatggg aatgtggctt gggcaaagca ctgatgccat caacttcaga cttgacgtct     5040

tactcctgag gcagagcagg gtgtgcctgt ggagggcgtg gggaggtggc ccgtggggag     5100

tggactgccg ctttaatccc ttcagctgcc tttccgctgt tgttttgatt tttctagaga     5160

ggaacataaa aagcattcgt ccggttgcgc tttcctttct gtcaagaagc agtttgaaga     5220

attaaccctt ggtgaatttt tgaaactgga cagagaaaga gccaagaaca aaattgtatg     5280

tattgggaat aagaactgct caaaccctgt tcaatgtctt tagcactaaa ctacctagtc     5340

cctcaaaggg actctgtgtt ttcctcagga agcatttttt ttttttttct gagatagagt     5400

ttcactcttg ttgcccaggc tggagtgcaa tggtgcaatc ttggctcact gcaacctctg     5460

cctctcgggt tcaagtgatt ctcctgcctc agcctcccaa gtaactggga ttacagggaa     5520

gtgccaccac acccagctaa tttttgtatt tttagtagag atggggtttc accacattgc     5580

ccaggctggt cttgaactcc tgacctcgtg attcgcccac cttggcctcc caaagtgctg     5640

ggattacagg cgtgaaccac cacgcctggc tttttttttt ttgttctgag acacagtttc     5700

actctgttac ccaggctgga gtagggtggc ctgatctcgg atcactgcaa cctccgcctc     5760

ctgggctcaa gtgatttgcc tgcttcagcc tcccaagtag ccgagattac aggcatgtgc     5820

caccacaccc aggtaatttt tgtatttttg gtagagacga ggtttcacca tgttggccag     5880

gctggttttg aactcctgac ctcaggtgat ccacccgcct cagcctccca aagtgctgag     5940

attataggtg tgagccacca cacctggcct caggaagtat ttttattttt aaatttattt     6000

atttatttga gatggagtct tgctctgtcg cccaggctag agtgcagcga cgggatctcg     6060

gctcactgca agctccgccc cccaggttca agccattctc ctgcctcagc ctcccgagta     6120

gctgggacta caggcgcccg ccaccacacc cggctaattt ttttgtattt ttagtagaga     6180

cgggttttca ccgtgttagc caggagggtc ttgatctcct gacctcgtga tctgcctgcc     6240

tcggcctccc aaagtgctgg gattacaggt gtgagccacc acacccggct atttttattt     6300

ttttgagaca gggactcact ctgtcacctg ggctgcagtg cagtggtaca ccatagctca     6360

ctgcagcctc gaactcctga gctcaagtga tcctcccacc tcatcctcac aagtaattgg     6420

gactacaggt gcaccccacc atgcccacct aatttattta tttatttatt tatttatttt     6480

catagagatg agggttccct gtgttgtcca ggctggtctt gaactcctga gctcacggga     6540

tccttttgcc tgggcctccc aaagtgctga gattacaggc atgagccacc gtgcccagct     6600

aggaatcatt tttaaagccc ctaggatgtc tgtgtgattt taaagctcct ggagtgtggc     6660

cggtataagt atataccggt ataagtaaat cccacatttt gtgtcagtat ttactagaaa     6720

cttagtcatt tatctgaagt tgaaatgtaa ctgggcttta tttatttatt tatttattta     6780

tttattttta attttttttt ttgagacgag tctcactttg tcacccaggc tggagtgcag     6840

tggcacgatc tcggctcact gcaacctctg cctcccgggg tcaagcgatt ctcctgcctt     6900

agcctcccga gtagctggga ctacaggcac gcaccaccat gcctggctaa tttttgtatt     6960

tttagtagac ggggtttcac catgctggcc aagctggtct caaactcctg accttgtgat     7020

ctgcccgctt tagcctccca gagtgctggg attacaggca tgagccacca tgcgtggtct     7080

ttttaaaatt ttttgatttt tttttttttt gagacagagc cttgctctgt cgcccaggct     7140

ggagtgcagt ggcacgatct cagctcacta caagctccgc ctcccgggtt cacgccattc     7200

ttctgcctca gcctcctgag tagctgggac tacaggtgcc caccaccacg cctggctaat     7260

tttttttggt atttttatta gagacaaggt ttcatcatgt tggccaggct ggtctcaaac     7320

tcctgacctc aagtgatctg cctgcctcgg cctcccaaag cgctgagatt acaggtgtga     7380

tctactgcgc caggcctggg cgtcatatat tcttatttgc taagtctggc agccccacac     7440

agaataagta ctgggggatt ccatatcctt gtagcaaagc cctgggtgga gagtcaggag     7500

atgttgtagt tctgtctctg ccacttgcag actttgagtt taagccagtc gtgctcatgc     7560

tttccttgct aaatagaggt tagaccccct atcccatggt ttctcaggtt gcttttcagc     7620

ttgaaaattg tattcctttg tagagatcag cgtaaaataa ttctgtcctt atatgtggct     7680

ttattttaat ttgagacaga gtgtcactca gtcgcccagg ctggagtgtg gtggtgcgat     7740

cttggctcac tgcgacctcc acctcccagg ttcaagcgat tctcgtgcct caggctccca     7800

agtagctgag attataggtg tgtgccacca ggcccagcta acttttgtat ttttagtaga     7860

gacagggttt tgccatgttg gctaagctgg tctcgaactc ctggcctcaa gtgatctgcc     7920

cgccttggca tcccaaagtg ctgggattac aggtgtgaac caccacacct ggcctcaata     7980

tagtggcttt taagtgctaa ggactgagat tgtgttttgt caggaagagg ccagttgtgg     8040

gtgaagcatg ctgtgagaga gcttgtcacc tggttgaggt tgtgggagct gcagcgtggg     8100

aactggaaag tgggctgggg atcatctttt tccaggtcag gggtcagcca gcttttctgc     8160

agcgtgccat agaccatctc ttagccctcg tgggtcagag tctctgttgc atattgtctt     8220

ttgttgtttt tcacaacctt ttagaaacat aaaaagcatt cttagcccgt gggctggaca     8280

aaaaaaggcc atgacgggct gtatggattt ggcccagcag gcccttgctt gccaagccct     8340

gttttagaca aggagcagct tgtgtgcctg gaaccatcat gggcacaggg gaggagcaga     8400

gtggatgtgg aggtgtgagc tggaaaccag gtcccagagc gctgagaaag acagagggtt     8460

tttgcccttg caagtagagc aactgaaatc tgacaccatc cagttccaga aagccctgaa     8520

gtgctggtgg acgctgcggg gtgctccgct ctagggttac agggatgaag atgcagtctg     8580

gtagggggag tccactcacc tgttggaaga tgtgattaag aaaagtagac tttcagggcc     8640

gggcatggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggtggatcac     8700

gaggtcagga gatcgagacc atcctggcta acatggtgaa accccgtctt tactaaaaat     8760

acaaaaaatt agctgggcgt ggtggcgggc gcctgtagtc ccagctactc gggaggctga     8820

ggcaggagaa tggcgtgaac ctgggaggtg gagcttgctg tgagccgaga tcgcgccact     8880

gcactccagc ctgggcgaca gagcgagact ccgtctcaaa aaaaaaaaaa aaagtaggct     8940

ttcatgatgt gtgagctgaa ggcgcagtag gcagaagtag aggcctcagt ccctgcagga     9000

gacccctcgg tctctatctc ctgatagtca gacccagcca cactggaaag aggggagaca     9060

ttacagcctg cgagaaaagt agggagattt aaaaactgct tggcttttat tttgaactgt     9120

tttttttgtt tgtttgtttt ccccaattca gaatacagaa tacttttatg gatttgtttt     9180

tattacttta attttgaaac aatataatct tttttttgtt gtttttttga gacagggtct     9240

tactctgtca cccaggctga gtgcagtggt gtgatcttgg ctcacctcag cctcgacccc     9300

ctgggctcaa atgattctcc cacctcagct tcccaagtag ctgggaccac aggtgcgtgt     9360

gttgcgctat acaaatcctg aagacaagga tgctgttgct ggtgatgctg gggattccca     9420

agatcccaga tttgatggca ggatgcccct gtctgctgcc ttgccagggt gccaggaggg     9480

cgctgctgtg gaagctgagg cccggccatc cagggcgatg cattgggcgc tgattcttgt     9540

tcctgctgct gcctcggtgc ttagcttttg aaacaatgaa ataaattaga accagtgtga     9600

aaatcgatca gggaataaat ttaatgtgga aataaactga acaacttagt tcttcataag     9660

agtttacttg gtaaatactt gtgatgagga caaaacgaag cactagaagg agaggcgagt     9720

tgtagacctg ggtggcagga gtgttttgtt tgttttcttt ggcagggtct tgctctgttg     9780

ctcaggctgg agtacagtgg cacaatcaca gctcactata gcctcgacct cctggactca     9840

agcaatcctc ctgcctcagc ctcccagtag ctgggactac aggcgcatgc caccatgcct     9900

ggctaatttt aaattttttt ttttctcttt tttgagatgg aatctcactc tgtcgcccag     9960

gctggagtgc agtggcgtga tctcggctga cggcaagctc cgcctcccag gttcactcca    10020

ttcgcctgcc tcagcctccc aagtagctgg gactacaggc gctgggatta caaacccaaa    10080

cccaaagtgc tgggattaca ggcgtgagcc actgcacccg gcctgttttg tctttcaata    10140

gcaagagttg tgtttgcttc gcccctacct ttagtggaaa aatgtataaa atggagatat    10200

tgacctccac attggggtgg ttaaattata gcatgtatgc aaaggagctt cgctaattta    10260

aggctttttt gaaagagaag aaactgaata atccatgtgt gtatatatat tttaaaagcc    10320

atggtcatct ttccatatca gtaaagctga ggctccctgg gactgcagag ttgtccatca    10380

cagtccatta taagtgcgct gctgggccag gtgcagtggc ttgtgcctga atcccagcac    10440

tttgggaggc caaggcagga ggattcattg agcccaggag ttttgaggcg agcctgggca    10500

atgtggccag acctcatctc ttcaaaaaat acacaaaaaa ttagccaggc atggtggcac    10560

gtgcctgtag tctcagctac tcaggaggct gaggtgggag gatcactttg agccttgcag    10620

gtcaaagctg cagtaagcca tgatcttgcc actgcattcc agcctggatg acagagcgag    10680

accctgtctc taaaaaaaaa aaaaaccaaa cggtgcactg ttttcttttt tcttatcaat    10740

ttattatttt taaattaaat tttcttttaa taatttataa attataaatt tatattaaaa    10800

aatgacaaat ttttattact tatacatgag gtaaaactta ggatatataa agtacatatt    10860

gaaaagtaat tttttggctg gcacagtggc tcacacctgt aatcccagca ctttgggagg    10920

ccgtggcggg cagatcacat gagatcatga gttcgagacc aacctgacca acatggagag    10980

accccatctc tactaaaaat acaaaattag ccggggtggt ggcgcatgcc tgtaatccca    11040

gctactcggg aggctgaggc aggagaatct cttgaacccg ggaggcagag gttgcggtga    11100

gccaagatcg tgcctttgca caccagccta ggcaacaaga gcgaaagtcc gtctcaaaaa    11160

aaaagtaatt ttttttaagt taacctctgt cagcaaacaa atttaaccca ataaaggtct    11220

ttgtttttta atgtagtaga ggagttaggg tttataaaaa atatggtagg gaagggggtc    11280

cctggatttg ctaatgtgat tgtcatttgc cccttaggag agagctctgt tagcagaatg    11340

aaaaaattgg aagccagatt cagggaggga ctggaagcaa aagaatttct gttcgaggaa    11400

gagcctgatg tttgccaggg tctgtttaac tggacatgaa gaggaaggct ctggactttc    11460

ctccaggagt ttcaggagaa aggtagggca gtggttaaga gcagagctct gcctagacta    11520

gctggggtgc ctagactagc tggggtgccc agactagctg gggtgcctag actagctggg    11580

tactttgagt ggctccttca gcctggacct cggtttcctc acctgtatag tagagatatg    11640

ggagcaccca gcgcaggatc actgtgaaca taaatcagtt aatggaggaa gcaggtagag    11700

tggtgctggg tgcataccaa gcactccgtc agtgtttcct gttattcgat gattaggagg    11760

cagcttaaac tagagggagt tgagctgaat caggatgttt gtcccaggta gctgggaatc    11820

tgcctagccc agtgcccagt ttatttaggt gctctctcag tgttccctga ttgttttttc    11880

ctttgtcatc ttatctacag gatgtgactg ggaagctctg gtttcagtgt catgtgtcta    11940

ttctttattt ccaggcaaag gaaaccaaca ataagaagaa agaatttgag gaaactgcga    12000

agaaagtgcg ccgtgccatc gagcagctgg ctgccatgga ttgaggcctc tggccggagc    12060

tgcctggtcc cagagtggct gcaccacttc cagggtttat tccctggtgc caccagcctt    12120

cctgtgggcc ccttagcaat gtcttaggaa aggagatcaa cattttcaaa ttagatgttt    12180

caactgtgct cctgttttgt cttgaaagtg gcaccagagg tgcttctgcc tgtgcagcgg    12240

gtgctgctgg taacagtggc tgcttctctc tctctctctc ttttttgggg gctcattttt    12300

gctgttttga ttcccgggct taccaggtga gaagtgaggg aggaagaagg cagtgtccct    12360

tttgctagag ctgacagctt tgttcgcgtg ggcagagcct tccacagtga atgtgtctgg    12420

acctcatgtt gttgaggctg tcacagtcct gagtgtggac ttggcaggtg cctgttgaat    12480

ctgagctgca ggttccttat ctgtcacacc tgtgcctcct cagaggacag tttttttgtt    12540

gttgtgtttt tttgtttttt ttttttggta gatgcatgac ttgtgtgtga tgagagaatg    12600

gagacagagt ccctggctcc tctactgttt aacaacatgg ctttcttatt ttgtttgaat    12660

tgttaattca cagaatagca caaactacaa ttaaaactaa gcacaaagcc attctaagtc    12720

attggggaaa cggggtgaac ttcaggtgga tgaggagaca gaatagagtg ataggaagcg    12780

tctggcagat actccttttg ccactgctgt gtgattagac aggcccagtg agccgcgggg    12840

cacatgctgg ccgctcctcc ctcagaaaaa ggcagtggcc taaatccttt ttaaatgact    12900

tggctcgatg ctgtggggga ctggctgggc tgctgcaggc cgtgtgtctg tcagcccaac    12960

cttcacatct gtcacgttct ccacacgggg gagagacgca gtccgcccag gtccccgctt    13020

tctttggagg cagcagctcc cgcagggctg aagtctggcg taagatgatg gatttgattc    13080

gccctcctcc ctgtcataga gctgcagggt ggattgttac agcttcgctg gaaacctctg    13140

gaggtcatct cggctgttcc tgagaaataa aaagcctgtc atttcaaaca ctgctgtgga    13200

ccctactggg tttttaaaat attgtcagtt tttcatcgtc gtccctagcc tgccaacagc    13260

catctgccca gacagccgca gtgaggatga gcgtcctggc agagacgcag ttgtctctgg    13320

gcgcttgcca gagccacgaa ccccagacct gtttgtatca tccgggctcc ttccgggcag    13380

aaacaactga aaatgcactt cagacccact tatttatgcc acatctgagt cggcctgaga    13440

tagacttttc cctctaaact gggagaatat cacagtggtt tttgttagca gaaaatgcac    13500

tccagcctct gtactcatct aagctgctta tttttgatat ttgtgtcagt ctgtaaatgg    13560

atacttcact ttaataactg ttgcttagta attggctttg tagagaagct ggaaaaaaat    13620

ggttttgtct tcaactcctt tgcatgccag gcggtgatgt ggatctcggc ttctgtgagc    13680

ctgtgctgtg ggcagggctg agctggagcc gcccctctca gcccgcctgc cacggccttt    13740

ccttaaaggc catccttaaa accagaccct catggctgcc agcacctgaa agcttcctcg    13800

acatctgtta ataaagccgt aggcccttgt ctaagcgcaa ccgcctagac tttctttcag    13860

atacatgtcc acatgtccat ttttcaggtt ctctaagttg gagtggagtc tgggaagggt    13920

tgtgaatgag gcttctgggc tatgggtgag gttccaatgg caggttagag cccctcgggc    13980

caactgccat cctggaaagt agagacagca gtgcccgctg cccagaagag accagcaagc    14040

caaactggag cccccattgc aggctgtcgc catgtggaaa gagtaactca caattgccaa    14100

taaagtctca tgtggtttta tctacttttt ttttcttttt cttttttttt gagacaaggc    14160

cttgccctcc caggctggag tgcagtggaa tgaccacagc tcaccgcaac ctcaaattct    14220

tgcgttcaag tgaacctccc actttagcct cccaagtagc tgggactaca ggcgcacgcc    14280

atcacacccg gctaattgaa aaattttttt ttttgtttag atggaatctc actttgttgc    14340

ccaggctggt ctcaaactcc tgggctcaag tgatcatcct gcttcagcgt ccgacttgtt    14400

ggtattatag gcgtgagcca ctgggcctga cctagctacc attttttaat gcagaaatga    14460

agacttgtag aaatgaaata acttgtccag gatagtcgaa taagtaactt ttagagctgg    14520

gatttgaacc caggcaatct ggctccagag ctgggccctc actgctgaag gacactgtca    14580

gcttgggagg gtggctatgg tcggctgtct gattctaggg agtgagggct gtctttaaag    14640

caccccattc cattttcaga cagctttgtc agaaaggctg tcatatggag ctgacacctg    14700

cctccccaag gcttccatag atcctctctg tacattgtaa ccttttattt tgaaatgaaa    14760

attcacagga agttgtaagg ctagtacagg ggatcc                              14796


<210>  22
<211>  4242
<212>  DNA
<213>  Homo sapiens

<400>  22
cttttgtctg tccgccgagc accccacttc accccattgg accgcgcggc cgccgctaga       60

gctctgcgcc tgcgcacgca ccgggccggg gactgggtgg cctggtgtgt gggcgcggca      120

gggcgcaggc gcaggcgcag tgtgcgtccg cgtctgaggg gagggatgtg ggggaagcga      180

cggcccccgg tttgtttggg ctgtgggcgg tgcgcagcgg agagcccggg aaaagcggga      240

aatggcggcg ccgagcgcgg ggtcttggtc caccttccag cacaaggagc tgatggccgc      300

tgacagggga cgcaggatat tgggagtgtg tggcatgcat cctcatcatc aggaaactct      360

aaaaaagaac cgagtggtgc tagccaaaca gctgttgttg agcgaattgt tagaacatct      420

tctggagaag gacatcatca ccttggaaat gagggagctc atccaggcca aagtgggcag      480

tttcagccag aatgtggaac tcctcaactt gctgcctaag aggggtcccc aagcttttga      540

tgccttctgt gaagcactga gggagaccaa gcaaggccac ctggaggata tgttgctcac      600

caccctttct gggcttcagc atgtactccc accgttgagc tgtgactacg acttgagtct      660

cccttttccg gtgtgtgagt cctgtcccct ttacaagaag ctccgcctgt cgacagatac      720

tgtggaacac tccctagaca ataaagatgg tcctgtctgc cttcaggtga agccttgcac      780

tcctgaattt tatcaaacac acttccagct ggcatatagg ttgcagtctc ggcctcgtgg      840

cctagcactg gtgttgagca atgtgcactt cactggagag aaagaactgg aatttcgctc      900

tggaggggat gtggaccaca gtactctagt caccctcttc aagcttttgg gctatgacgt      960

ccatgttcta tgtgaccaga ctgcacagga aatgcaagag aaactgcaga attttgcaca     1020

gttacctgca caccgagtca cggactcctg catcgtggca ctcctctcgc atggtgtgga     1080

gggcgccatc tatggtgtgg atgggaaact gctccagctc caagaggttt ttcagctctt     1140

tgacaacgcc aactgcccaa gcctacagaa caaaccaaaa atgttcttca tccaggcctg     1200

ccgtggagat gagactgatc gtggggttga ccaacaagat ggaaagaacc acgcaggatc     1260

ccctgggtgc gaggagagtg atgccggtaa agaaaagttg ccgaagatga gactgcccac     1320

gcgctcagac atgatatgcg gctatgcctg cctcaaaggg actgccgcca tgcggaacac     1380

caaacgaggt tcctggtaca tcgaggctct tgctcaagtg ttttctgagc gggcttgtga     1440

tatgcacgtg gccgacatgc tggttaaggt gaacgcactt atcaaggatc gggaaggtta     1500

tgctcctggc acagaattcc accggtgcaa ggagatgtct gaatactgca gcactctgtg     1560

ccgccacctc tacctgttcc caggacaccc tcccacatga tgtcacctcc ccatcatcca     1620

cgccaagtgg aagccactgg accacaggag gtgtgataga gcctttgatc ttcaggatgc     1680

acggtttctg ttctgccccc tcagggatgt gggaatctcc cagacttgtt tcctgtgccc     1740

atcatctctg cctttgagtg tgggactcca ggccagctcc ttttctgtga agccctttgc     1800

ctgtagagcc agccttggtt ggacctattg ccaggaatgt ttcagctgca gttgaagagc     1860

ctgacaagtg aagttgtaaa cacagtgtgg ttatggggag agggcatata aattccccat     1920

atttgtgttc agttccagct tttgtagatg gcactttagt gattgctttt attacattag     1980

ttaagatgtc tgagagacca tctcctatct tttatttcat tcatatcctc cgcccttttt     2040

gtcctagagt gagagtttgg aaggtgtcca aatttaatgt agacattatc ttttggctct     2100

gaagaagcaa acatgactag agacgcacct tgctgcagtg tccagaagcg gcctgtgcgt     2160

tcccttcagt actgcagcgc cacccagtgg aaggacactc ttggctcgtt tgggctcaag     2220

gcaccgcagc ctgtcagcca acattgcctt gcatttgtac cttattgatc tttgcccatg     2280

gaagtctcaa agatctttcg ttggttgttt ctctgagctt tgttactgaa atgagcctcg     2340

tggggagcat cagagaaggc caggaagaat ggtgtgtttc cctagactct gtaaccacct     2400

ctctgtcttt ttccttcctg agaaacgtcc atctctctcc cttactattc ccactttcat     2460

tcaatcaacc tgcacttcat atctagattt ctagaaaagc ttcctagctt atctccctgc     2520

ttcatatctc tcccttcttt accttcattt catcctgttg gctgctgcca ccaaatctgt     2580

ctagaatcct gctttacagg atcatgtaaa tgctcaaaga tgtaatgtag ttctttgttc     2640

ctgctttctc tttcagtatt aaactctcct ttgatattat gtggctttta tttcagtgcc     2700

atacatgtta ttgttttcaa cctagaaacc tttatccctg cttatctgaa acttcccaac     2760

ttccctgttc tttaagactt tttttttttt tttttttttt tttgagacag agtctcgctc     2820

tgtcgcccag gctggagggc agtggcacga tctcagctca ctgcaagctc caactcccgg     2880

gttcacgcca ttctcctgcc tcagccttcc aagtagctgg gactacaggt gcccgccacc     2940

gtgcccggct aatttttttg tatttttagt agagacaggg tttcaccatg ttagccggga     3000

tggtcttgat ctcctgacct catgatccac ccacctcagc ctcccaaagt gttgggatta     3060

caggcgtgag ccactgcgcc cgggcaagac ctttttttaa aaaaaaaaaa aaaaaaactt     3120

ccattctttc ttcctccagt ctgttctcac ataacagagt agttttggtt tttaattttt     3180

tttggttgtt tgctgttttt tgttttttaa ggtgagttct cactatgttt ctcagactgg     3240

tctcgaactc ctggcctcaa gccatcttcc cgcctcagcc tctcaaatag ctgggcttac     3300

aggcatgagc caccacacct ggccaggatt tggttgttta aatataaatc tgatcacccc     3360

cctgcttaga acccttctgc tttctattac ccctcattta aaatgtaaac tcttcacctt     3420

ggtttatgag aactggttct tgccttcccc ttgaacctca ttaaatggtg atttcttgct     3480

aagctccagc ccgagtggtc tcctctcagc ttctaatttt gtgctctttc ctgccctttt     3540

cctgggcctt ctcagctctc cacccccacc actcttgact caggtggtgt ccttcttcct     3600

caagtcttga caattcccgg gcccttcagt ccctgagcag tctacttctg tgtctgtcac     3660

cacatcttgt cttttcccct cattgcattt attgcagttt atatatatgc tacttttact     3720

tgttcatttc tgtctcccct accaggctgt aaatgagggc agaaaccttg tttgttttat     3780

tcaccatcat gtaccaagtg cttggcacat agtgggcctt cattaaatgt ttgttgaata     3840

aaagagggaa gaaggcaagc caaccttagc tacaatccta ccttttgata aaatgttcct     3900

tttgacaata tacacggatt attatttgta ctttgttttt ccatgtgttt tgcttttatc     3960

cactggcatt tttagctcct tgaagacata tcatgtgtga gataacttcc ttcacatctc     4020

ccatggtccc tagcaaaatg ctaggcctgt agtagtcaag gtgctcaata aatatttgtt     4080

tgggtggttt gtgagccttg ctgccaagtc ctgcctttgg gtcgacatag tatggaagta     4140

tttgagagag agaacctttc cactcccact gccaggattt tgtattgcca tcgggtgcca     4200

aataaatgct catatttatt actgaaaaaa aaaaaaaaaa aa                        4242


<210>  23
<211>  2689
<212>  DNA
<213>  Homo sapiens

<400>  23
acatctcccg gcggcgggcc gcggaagcag tgcagacgcg gctcctagcg gatgggtgct       60

attgtgaggc ggttgtagaa gagtttcgtg agtgctcgca gctcatacct gtggctgtgt      120

atccgtggcc acagctggtt ggcgtcgcct tgaaatccca ggccgtgagg agttagcgag      180

ccctgctcac actcggcgct ctggttttcg gtgggtgtgc cctgcacctg cctcttcccc      240

cattctcatt aataaaggta tccatggaga acactgaaaa ctcagtggat tcaaaatcca      300

ttaaaaattt ggaaccaaag atcatacatg gaagcgaatc aatggactct ggaatatccc      360

tggacaacag ttataaaatg gattatcctg agatgggttt atgtataata attaataata      420

agaattttca taaaagcact ggaatgacat ctcggtctgg tacagatgtc gatgcagcaa      480

acctcaggga aacattcaga aacttgaaat atgaagtcag gaataaaaat gatcttacac      540

gtgaagaaat tgtggaattg atgcgtgatg tttctaaaga agatcacagc aaaaggagca      600

gttttgtttg tgtgcttctg agccatggtg aagaaggaat aatttttgga acaaatggac      660

ctgttgacct gaaaaaaata acaaactttt tcagagggga tcgttgtaga agtctaactg      720

gaaaacccaa acttttcatt attcaggcct gccgtggtac agaactggac tgtggcattg      780

agacagacag tggtgttgat gatgacatgg cgtgtcataa aataccagtg gaggccgact      840

tcttgtatgc atactccaca gcacctggtt attattcttg gcgaaattca aaggatggct      900

cctggttcat ccagtcgctt tgtgccatgc tgaaacagta tgccgacaag cttgaattta      960

tgcacattct tacccgggtt aaccgaaagg tggcaacaga atttgagtcc ttttcctttg     1020

acgctacttt tcatgcaaag aaacagattc catgtattgt ttccatgctc acaaaagaac     1080

tctattttta tcactaaaga aatggttggt tggtggtttt ttttagtttg tatgccaagt     1140

gagaagatgg tatatttggt actgtatttc cctctcattt tgacctactc tcatgctgca     1200

gagggtactt taagacatac tccttccatc aaatagaacc actatgaagc tacctcaaac     1260

ttccagtcag gtagttgcaa ttgaattaaa ttaggaataa ataaaaatgg atactggtgc     1320

agtcattatg agaggcaatg attgttaatt tacagctttc atgattagca agttacagtg     1380

atgctgtgct atgaattttc aagtaattgt gaaaaagtta aacattgaag taatgaattt     1440

ttatgatatt ccccccactt aagactgtgt attctagttt tgtcaaactg tagaaatgat     1500

gatgtggaag aacttaggca tctgtgggca tggtcaaagg ctcaaacctt tattttagaa     1560

ttgatataca cggatgactt aactgcattt ttagaccatt tatctgggat tatggttttg     1620

tgatgtttgt cctgaacact tttgttgtaa aaaaataata ataatgttta atattgagaa     1680

agaaactaat attttatgtg agagaaagtg tgagcaaact aacttgactt ttaaggctaa     1740

aacttaacat tcatagaggg gtggagtttt aactgtaagg tgctacaatg cccctggatc     1800

taccagcata aatatcttct gatttgtccc tatgcatatc agttgagctt catataccag     1860

caatatatct gaagagctat tatataaaaa ccccaaactg ttgattatta gccaggtaat     1920

gtgaataaat tctataggaa catatgaaaa tacaacttaa ataataaaca gtggaatata     1980

aggaaagcaa taaatgaatg ggctgagctg cctgtaactt gagagtagat ggtttgagcc     2040

tgagcagaga catgactcag cctgttccat gaaggcagag ccatggacca cgcaggaagg     2100

gcctacagcc catttctcca tacgcactgg tatgtgtgga tgatgctgcc agggcgccat     2160

cgccaagtaa gaaagtgaag caaatcagaa acttgtgaag tggaaatgtt ctaaaggtgg     2220

tgaggcaata aaaatcatag tactctttgt agcaaaattc ttaagtatgt tattttctgt     2280

tgaagtttac aatcaaagga aaatagtaat gttttatact gtttactgaa agaaaaagac     2340

ctatgagcac ataggactct agacggcatc cagccggagg ccagagctga gccctcagcc     2400

cgggaggcag gctccaggcc tcagcaggtg cggagccgtc actgcaccaa gtctcactgg     2460

ctgtcagtat gacatttcac gggagatttc ttgttgctca aaaaatgagc tcgcatttgt     2520

caatgacagt ttcttttttc ttactagacc tgtaactttt gtaaatacac atagcatgta     2580

atggtatctt aaagtgtgtt tctatgtgac aattttgtac aaatttgtta ttttccattt     2640

ttatttcaaa atatacattc aaacttaaaa ttaaaaaaaa aaaaaaaaa                 2689


<210>  24
<211>  2607
<212>  DNA
<213>  Homo sapiens

<400>  24
cccgcgcgcg ggctcaactt tgtagagcga ggggccaact tggcagagcg cgcggccagc       60

tttgcagaga gcgccctcca gggactatgc gtgcggggac acgggtcgct ttgggctctt      120

ccacccctgc ggagcgcact accccgagcc aggggcggtg caagccccgc ccggccctac      180

ccagggcggc tcctccctcc gcagcgccga gacttttagt ttcgctttcg ctaaaggggc      240

cccagaccct tgctgcggag cgacggagag agactgtgcc agtcccagcc gccctaccgc      300

cgtgggaacg atggcagatg atcagggctg tattgaagag cagggggttg aggattcagc      360

aaatgaagat tcagtggatg ctaagccaga ccggtcctcg tttgtaccgt ccctcttcag      420

taagaagaag aaaaatgtca ccatgcgatc catcaagacc acccgggacc gagtgcctac      480

atatcagtac aacatgaatt ttgaaaagct gggcaaatgc atcataataa acaacaagaa      540

ctttgataaa gtgacaggta tgggcgttcg aaacggaaca gacaaagatg ccgaggcgct      600

cttcaagtgc ttccgaagcc tgggttttga cgtgattgtc tataatgact gctcttgtgc      660

caagatgcaa gatctgctta aaaaagcttc tgaagaggac catacaaatg ccgcctgctt      720

cgcctgcatc ctcttaagcc atggagaaga aaatgtaatt tatgggaaag atggtgtcac      780

accaataaag gatttgacag cccactttag gggggataga tgcaaaaccc ttttagagaa      840

acccaaactc ttcttcattc aggcttgccg agggaccgag cttgatgatg gcatccaggc      900

cgactcgggg cccatcaatg acacagatgc taatcctcga tacaagatcc cagtggaagc      960

tgacttcctc ttcgcctatt ccacggttcc aggctattac tcgtggagga gcccaggaag     1020

aggctcctgg tttgtgcaag ccctctgctc catcctggag gagcacggaa aagacctgga     1080

aatcatgcag atcctcacca gggtgaatga cagagttgcc aggcactttg agtctcagtc     1140

tgatgaccca cacttccatg agaagaagca gatcccctgt gtggtctcca tgctcaccaa     1200

ggaactctac ttcagtcaat agccatatca ggggtacatt ctagctgaga agcaatgggt     1260

cactcattaa tgaatcacat ttttttatgc tcttgaaata ttcagaaatt ctccaggatt     1320

ttaatttcag gaaaatgtat tgattcaaca gggaagaaac tttctggtgc tgtcttttgt     1380

tctctgaatt ttcagagact ttttttataa tgttattcat ttggtgactg tgtaactttc     1440

tcttaagatt aattttctct ttgtatgtct gttaccttgt taatagactt aatacatgca     1500

acagaagtga cttctggaga aagctcatgg ctgtgtccac tgcaattggt ggtaacagtg     1560

gtagagtcat gtttgcactt ggcaaaaaga atcccaatgt ttgacaaaac acagccaagg     1620

ggatatttac tgctctttat tgcagaatgt gggtattgag tgtgatttga atgatttttc     1680

attggcttag ggcagatttt catgcaaaag ttctcatatg agttagagga gaaaaagctt     1740

aatgattctg atatgtatcc atcaggatcc agtctggaaa acagaaacca ttctaggtgt     1800

ttcaacagag ggagtttaat acaggaaatt gacttacata gatgataaaa gagaagccaa     1860

acagcaagaa gctgttacca cacccagggc tatgaggata atgggaagag gtttggtttc     1920

ctgtgtccag tagtgggatc atccagagga gctggaacca tggtgggggc tgcctagtgg     1980

gagttaggac caccaatgga ttgtggaaaa tggagccatg acaagaacaa agccactgac     2040

tgagatggag tgagctgaga cagataagag aataccttgg tctcacctat cctgccctca     2100

catcttccac cagcacctta ctgcccaggc ctatctggaa gccacctcac caaggacctt     2160

ggaagagcaa gggacagtga ggcaggagaa gaacaagaaa tggatgtaag cctggcccat     2220

aatgtgaaca taagtaatca ctaatgctca acaatttatc cattcaatca tttattcatt     2280

gggttgtcag atagtctatg tatgtgtaaa acaatctgtt ttggctttat gtgcaaaatc     2340

tgttatagct ttaaaatata tctggaactt tttagattat tccaagcctt attttgagta     2400

aatatttgtt acttttagtt ctataagtga ggaagagttt atggcaaaga tttttggcac     2460

tttgttttca agatggtgtt atcttttgaa ttcttgataa atgactgttt ttttctgcct     2520

aatagtaact ggttaaaaaa caaatgttca tatttattga ttaaaaatgt ggttgcttaa     2580

ttcctaacca gaaaaaaaaa aaaaaaa                                         2607


<210>  25
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 
            100                 105                 110         


Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 
        115                 120                 125             


Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
    130                 135                 140                 


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
145                 150                 155                 160 


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
                165                 170                 175     


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
            180                 185                 190         


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
        195                 200                 205             


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
    210                 215                 220                 


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
225                 230                 235                 240 


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
                245                 250                 255     


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
            260                 265                 270         


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
        275                 280                 285             


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His His Asp Cys 
    290                 295                 300                 


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
305                 310                 315                 320 


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
                325                 330                 335     


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
            340                 345                 350         


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
        355                 360                 365             


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
    370                 375                 380                 


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
385                 390                 395                 400 


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
                405                 410                 415     


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
            420                 425                 430         


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
        435                 440                 445             


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
    450                 455                 460                 


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
465                 470                 475                 480 


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
                485                 490                 495     


<210>  26
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Ser 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Pro His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                405                 410                 415     


