                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
 
<120>  Compositions And Methods For Modulating Thermogenesis Using 
       PTH-Related And EGF-Related Molecules

<130>  DFS-120.25

<140>  PCT/US2014/048870
<141>  2014-07-30

<150>  61/900,629
<151>  2013-11-06

<150>  61/860,367
<151>  2013-07-13

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  483
<212>  DNA
<213>  Homo sapiens

<400>  1
atggtcccct cggctggaca gctcgccctg ttcgctctgg gtattgtgtt ggctgcgtgc       60

caggccttgg agaacagcac gtccccgctg agtgcagacc cgcccgtggc tgcagcagtg      120

gtgtcccatt ttaatgactg cccagattcc cacactcagt tctgcttcca tggaacctgc      180

aggtttttgg tgcaggagga caagccagca tgtgtctgcc attctgggta cgttggtgca      240

cgctgtgagc atgcggacct cctggccgtg gtggctgcca gccagaagaa gcaggccatc      300

accgccttgg tggtggtctc catcgtggcc ctggctgtcc ttatcatcac atgtgtgctg      360

atacactgct gccaggtccg aaaacactgt gagtggtgcc gggccctcat ctgccggcac      420

gagaagccca gcgccctcct gaagggaaga accgcttgct gccactcaga aacagtggtc      480

tga                                                                    483


<210>  2
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210>  3
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  3
atggtcccct cggctggaca gctcgccctg ttcgctctgg gtattgtgtt ggctgcgtgc       60

caggccttgg agaacagcac gtccccgctg agtgacccgc ccgtggctgc agcagtggtg      120

tcccatttta atgactgccc agattcccac actcagttct gcttccatgg aacctgcagg      180

tttttggtgc aggaggacaa gccagcatgt gtctgccatt ctgggtacgt tggtgcacgc      240

tgtgagcatg cggacctcct ggccgtggtg gctgccagcc agaagaagca ggccatcacc      300

gccttggtgg tggtctccat cgtggccctg gctgtcctta tcatcacatg tgtgctgata      360

cactgctgcc aggtccgaaa acactgtgag tggtgccggg ccctcatctg ccggcacgag      420

aagcccagcg ccctcctgaa gggaagaacc gcttgctgcc actcagaaac agtggtctga      480


<210>  4
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210>  5
<211>  480
<212>  DNA
<213>  Mus musculus

<400>  5
atggtccccg cgaccggaca gctcgctctg ctagcgctgg gtatcctgtt agctgtgtgc       60

caggctctgg agaacagcac atcccccctg agtgactcac ccgtggcggc tgcagtggtg      120

tctcacttca acaagtgccc agattcccac actcagtact gcttccatgg aacctgccgg      180

tttttggtgc aggaagagaa gccagcatgt gtctgccact ctgggtacgt gggtgttcgc      240

tgtgagcatg cagacctcct ggctgtggtg gctgccagcc agaagaagca agccatcact      300

gccctggtgg tggtctccat tgtggccctg gctgtcctca ttatcacctg tgtgctgatc      360

cactgctgtc agctccgcaa acactgtgag tggtgccgtg ccctcgtctg cagacatgag      420

aagcccagcg ccctcctgaa gggaaggact gcttgctgcc actctgagac agtggtctga      480


<210>  6
<211>  159
<212>  PRT
<213>  Mus musculus

<400>  6

Met Val Pro Ala Thr Gly Gln Leu Ala Leu Leu Ala Leu Gly Ile Leu 
1               5                   10                  15      


Leu Ala Val Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Ser Pro Val Ala Ala Ala Val Val Ser His Phe Asn Lys Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Tyr Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Glu Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Val Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Leu Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Val Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210>  7
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaccgcgg ggaggaggat ggagatgctc tgtgccggca gggtccctgc gctgctgctc       60

tgcctgggtt tccatcttct acaggcagtc ctcagtacaa ctgtgattcc atcatgtatc      120

ccaggagagt ccagtgataa ctgcacagct ttagttcaga cagaagacaa tccacgtgtg      180

gctcaagtgt caataacaaa gtgtagctct gacatgaatg gctattgttt gcatggacag      240

tgcatctatc tggtggacat gagtcaaaac tactgcaggt gtgaagtggg ttatactggt      300

gtccgatgtg aacacttctt tttaaccgtc caccaacctt taagcaaaga atatgtggct      360

ttgaccgtga ttcttattat tttgtttctt atcacagtcg tcggttccac atattatttc      420

tgcagatggt acagaaatcg aaaaagtaaa gaaccaaaga aggaatatga gagagttacc      480

tcaggggatc cagagttgcc gcaagtctga                                       510


<210>  8
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210>  9
<211>  489
<212>  DNA
<213>  Mus musculus

<400>  9
atggagacgc tccctgcctc ttgggtcttg acgctgcttt gtctaggttc ccaccttcta       60

caggcagtta tcagcacaac cgtgatccca tcatgcatcc caggagaatc cgaggataac      120

tgtaccgcct tagttcagat ggaagacgat ccccgtgtgg ctcaagtgca gattacaaag      180

tgtagttctg acatggacgg ctactgcttg catggccagt gcatctacct ggtggacatg      240

agagagaaat tctgcagatg tgaagtgggc tacactggtc tgcgatgtga gcacttcttt      300

ctaactgttc accaaccctt gagcaaagaa tacgttgcgt tgacagtgat tctcattttc      360

ctgtttctca tcataaccgc tggatgcata tactatttct gcagatggta caaaaatcga      420

aaaagtaaaa aatcgaggga ggaatatgag agagtgacct caggggaccc agtgctgcca      480

caggtctga                                                              489


<210>  10
<211>  162
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Thr Leu Pro Ala Ser Trp Val Leu Thr Leu Leu Cys Leu Gly 
1               5                   10                  15      


Ser His Leu Leu Gln Ala Val Ile Ser Thr Thr Val Ile Pro Ser Cys 
            20                  25                  30          


Ile Pro Gly Glu Ser Glu Asp Asn Cys Thr Ala Leu Val Gln Met Glu 
        35                  40                  45              


Asp Asp Pro Arg Val Ala Gln Val Gln Ile Thr Lys Cys Ser Ser Asp 
    50                  55                  60                  


Met Asp Gly Tyr Cys Leu His Gly Gln Cys Ile Tyr Leu Val Asp Met 
65                  70                  75                  80  


Arg Glu Lys Phe Cys Arg Cys Glu Val Gly Tyr Thr Gly Leu Arg Cys 
                85                  90                  95      


Glu His Phe Phe Leu Thr Val His Gln Pro Leu Ser Lys Glu Tyr Val 
            100                 105                 110         


Ala Leu Thr Val Ile Leu Ile Phe Leu Phe Leu Ile Ile Thr Ala Gly 
        115                 120                 125             


Cys Ile Tyr Tyr Phe Cys Arg Trp Tyr Lys Asn Arg Lys Ser Lys Lys 
    130                 135                 140                 


Ser Arg Glu Glu Tyr Glu Arg Val Thr Ser Gly Asp Pro Val Leu Pro 
145                 150                 155                 160 


Gln Val 
        


<210>  11
<211>  3624
<212>  DNA
<213>  Homo sapiens

<400>  11
atgctgctca ctcttatcat tctgttgcca gtagtttcaa aatttagttt tgttagtctc       60

tcagcaccgc agcactggag ctgtcctgaa ggtactctcg caggaaatgg gaattctact      120

tgtgtgggtc ctgcaccctt cttaattttc tcccatggaa atagtatctt taggattgac      180

acagaaggaa ccaattatga gcaattggtg gtggatgctg gtgtctcagt gatcatggat      240

tttcattata atgagaaaag aatctattgg gtggatttag aaagacaact tttgcaaaga      300

gtttttctga atgggtcaag gcaagagaga gtatgtaata tagagaaaaa tgtttctgga      360

atggcaataa attggataaa tgaagaagtt atttggtcaa atcaacagga aggaatcatt      420

acagtaacag atatgaaagg aaataattcc cacattcttt taagtgcttt aaaatatcct      480

gcaaatgtag cagttgatcc agtagaaagg tttatatttt ggtcttcaga ggtggctgga      540

agcctttata gagcagatct cgatggtgtg ggagtgaagg ctctgttgga gacatcagag      600

aaaataacag ctgtgtcatt ggatgtgctt gataagcggc tgttttggat tcagtacaac      660

agagaaggaa gcaattctct tatttgctcc tgtgattatg atggaggttc tgtccacatt      720

agtaaacatc caacacagca taatttgttt gcaatgtccc tttttggtga ccgtatcttc      780

tattcaacat ggaaaatgaa gacaatttgg atagccaaca aacacactgg aaaggacatg      840

gttagaatta acctccattc atcatttgta ccacttggtg aactgaaagt agtgcatcca      900

cttgcacaac ccaaggcaga agatgacact tgggagcctg agcagaaact ttgcaaattg      960

aggaaaggaa actgcagcag cactgtgtgt gggcaagacc tccagtcaca cttgtgcatg     1020

tgtgcagagg gatacgccct aagtcgagac cggaagtact gtgaagatgt taatgaatgt     1080

gctttttgga atcatggctg tactcttggg tgtaaaaaca cccctggatc ctattactgc     1140

acgtgccctg taggatttgt tctgcttcct gatgggaaac gatgtcatca acttgtttcc     1200

tgtccacgca atgtgtctga atgcagccat gactgtgttc tgacatcaga aggtccctta     1260

tgtttctgtc ctgaaggctc agtgcttgag agagatggga aaacatgtag cggttgttcc     1320

tcacccgata atggtggatg tagccagctc tgcgttcctc ttagcccagt atcctgggaa     1380

tgtgattgct ttcctgggta tgacctacaa ctggatgaaa aaagctgtgc agcttcagga     1440

ccacaaccat ttttgctgtt tgccaattct caagatattc gacacatgca ttttgatgga     1500

acagactatg gaactctgct cagccagcag atgggaatgg tttatgccct agatcatgac     1560

cctgtggaaa ataagatata ctttgcccat acagccctga agtggataga gagagctaat     1620

atggatggtt cccagcgaga aaggcttatt gaggaaggag tagatgtgcc agaaggtctt     1680

gctgtggact ggattggccg tagattctat tggacagaca gagggaaatc tctgattgga     1740

aggagtgatt taaatgggaa acgttccaaa ataatcacta aggagaacat ctctcaacca     1800

cgaggaattg ctgttcatcc aatggccaag agattattct ggactgatac agggattaat     1860

ccacgaattg aaagttcttc cctccaaggc cttggccgtc tggttatagc cagctctgat     1920

ctaatctggc ccagtggaat aacgattgac ttcttaactg acaagttgta ctggtgcgat     1980

gccaagcagt ctgtgattga aatggccaat ctggatggtt caaaacgccg aagacttacc     2040

cagaatgatg taggtcaccc atttgctgta gcagtgtttg aggattatgt gtggttctca     2100

gattgggcta tgccatcagt aatgagagta aacaagagga ctggcaaaga tagagtacgt     2160

ctccaaggca gcatgctgaa gccctcatca ctggttgtgg ttcatccatt ggcaaaacca     2220

ggagcagatc cctgcttata tcaaaacgga ggctgtgaac atatttgcaa aaagaggctt     2280

ggaactgctt ggtgttcgtg tcgtgaaggt tttatgaaag cctcagatgg gaaaacgtgt     2340

ctggctctgg atggtcatca gctgttggca ggtggtgaag ttgatctaaa gaaccaagta     2400

acaccattgg acatcttgtc caagactaga gtgtcagaag ataacattac agaatctcaa     2460

cacatgctag tggctgaaat catggtgtca gatcaagatg actgtgctcc tgtgggatgc     2520

agcatgtatg ctcggtgtat ttcagaggga gaggatgcca catgtcagtg tttgaaagga     2580

tttgctgggg atggaaaact atgttctgat atagatgaat gtgagatggg tgtcccagtg     2640

tgcccccctg cctcctccaa gtgcatcaac accgaaggtg gttatgtctg ccggtgctca     2700

gaaggctacc aaggagatgg gattcactgt cttgatattg atgagtgcca actgggggag     2760

cacagctgtg gagagaatgc cagctgcaca aatacagagg gaggctatac ctgcatgtgt     2820

gctggacgcc tgtctgaacc aggactgatt tgccctgact ctactccacc ccctcacctc     2880

agggaagatg accaccacta ttccgtaaga aatagtgact ctgaatgtcc cctgtcccac     2940

gatgggtact gcctccatga tggtgtgtgc atgtatattg aagcattgga caagtatgca     3000

tgcaactgtg ttgttggcta catcggggag cgatgtcagt accgagacct gaagtggtgg     3060

gaactgcgcc acgctggcca cgggcagcag cagaaggtca tcgtggtggc tgtctgcgtg     3120

gtggtgcttg tcatgctgct cctcctgagc ctgtgggggg cccactacta caggactcag     3180

aagctgctat cgaaaaaccc aaagaatcct tatgaggagt cgagcagaga tgtgaggagt     3240

cgcaggcctg ctgacactga ggatgggatg tcctcttgcc ctcaaccttg gtttgtggtt     3300

ataaaagaac accaagacct caagaatggg ggtcaaccag tggctggtga ggatggccag     3360

gcagcagatg ggtcaatgca accaacttca tggaggcagg agccccagtt atgtggaatg     3420

ggcacagagc aaggctgctg gattccagta tccagtgata agggctcctg tccccaggta     3480

atggagcgaa gctttcatat gccctcctat gggacacaga cccttgaagg gggtgtcgag     3540

aagccccatt ctctcctatc agctaaccca ttatggcaac aaagggccct ggacccacca     3600

caccaaatgg agctgactca gtga                                            3624


<210>  12
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  13
<211>  3501
<212>  DNA
<213>  Homo sapiens

<400>  13
atgctgctca ctcttatcat tctgttgcca gtagtttcaa aatttagttt tgttagtctc       60

tcagcaccgc agcactggag ctgtcctgaa ggtactctcg caggaaatgg gaattctact      120

tgtgtgggtc ctgcaccctt cttaattttc tcccatggaa atagtatctt taggattgac      180

acagaaggaa ccaattatga gcaattggtg gtggatgctg gtgtctcagt gatcatggat      240

tttcattata atgagaaaag aatctattgg gtggatttag aaagacaact tttgcaaaga      300

gtttttctga atgggtcaag gcaagagaga gtatgtaata tagagaaaaa tgtttctgga      360

atggcaataa attggataaa tgaagaagtt atttggtcaa atcaacagga aggaatcatt      420

acagtaacag atatgaaagg aaataattcc cacattcttt taagtgcttt aaaatatcct      480

gcaaatgtag cagttgatcc agtagaaagg tttatatttt ggtcttcaga ggtggctgga      540

agcctttata gagcagatct cgatggtgtg ggagtgaagg ctctgttgga gacatcagag      600

aaaataacag ctgtgtcatt ggatgtgctt gataagcggc tgttttggat tcagtacaac      660

agagaaggaa gcaattctct tatttgctcc tgtgattatg atggaggttc tgtccacatt      720

agtaaacatc caacacagca taatttgttt gcaatgtccc tttttggtga ccgtatcttc      780

tattcaacat ggaaaatgaa gacaatttgg atagccaaca aacacactgg aaaggacatg      840

gttagaatta acctccattc atcatttgta ccacttggtg aactgaaagt agtgcatcca      900

cttgcacaac ccaaggcaga agatgacact tgggagcctg agcagaaact ttgcaaattg      960

aggaaaggaa actgcagcag cactgtgtgt gggcaagacc tccagtcaca cttgtgcatg     1020

tgtgcagagg gatacgccct aagtcgagac cggaagtact gtgaagatgt taatgaatgt     1080

gctttttgga atcatggctg tactcttggg tgtaaaaaca cccctggatc ctattactgc     1140

acgtgccctg taggatttgt tctgcttcct gatgggaaac gatgtcatca acttgtttcc     1200

tgtccacgca atgtgtctga atgcagccat gactgtgttc tgacatcaga aggtccctta     1260

tgtttctgtc ctgaaggctc agtgcttgag agagatggga aaacatgtag cggttgttcc     1320

tcacccgata atggtggatg tagccagctc tgcgttcctc ttagcccagt atcctgggaa     1380

tgtgattgct ttcctgggta tgacctacaa ctggatgaaa aaagctgtgc agcttcagga     1440

ccacaaccat ttttgctgtt tgccaattct caagatattc gacacatgca ttttgatgga     1500

acagactatg gaactctgct cagccagcag atgggaatgg tttatgccct agatcatgac     1560

cctgtggaaa ataagatata ctttgcccat acagccctga agtggataga gagagctaat     1620

atggatggtt cccagcgaga aaggcttatt gaggaaggag tagatgtgcc agaaggtctt     1680

gctgtggact ggattggccg tagattctat tggacagaca gagggaaatc tctgattgga     1740

aggagtgatt taaatgggaa acgttccaaa ataatcacta aggagaacat ctctcaacca     1800

cgaggaattg ctgttcatcc aatggccaag agattattct ggactgatac agggattaat     1860

ccacgaattg aaagttcttc cctccaaggc cttggccgtc tggttatagc cagctctgat     1920

ctaatctggc ccagtggaat aacgattgac ttcttaactg acaagttgta ctggtgcgat     1980

gccaagcagt ctgtgattga aatggccaat ctggatggtt caaaacgccg aagacttacc     2040

cagaatgatg taggtcaccc atttgctgta gcagtgtttg aggattatgt gtggttctca     2100

gattgggcta tgccatcagt aatgagagta aacaagagga ctggcaaaga tagagtacgt     2160

ctccaaggca gcatgctgaa gccctcatca ctggttgtgg ttcatccatt ggcaaaacca     2220

ggagcagatc cctgcttata tcaaaacgga ggctgtgaac atatttgcaa aaagaggctt     2280

ggaactgctt ggtgttcgtg tcgtgaaggt tttatgaaag cctcagatgg gaaaacgtgt     2340

ctggctctgg atggtcatca gctgttggca ggtggtgaag ttgatctaaa gaaccaagta     2400

acaccattgg acatcttgtc caagactaga gtgtcagaag ataacattac agaatctcaa     2460

cacatgctag tggctgaaat catggtgtca gatcaagatg actgtgctcc tgtgggatgc     2520

agcatgtatg ctcggtgtat ttcagaggga gaggatgcca catgtcagtg tttgaaagga     2580

tttgctgggg atggaaaact atgttctgat atagatgaat gtgagatggg tgtcccagtg     2640

tgcccccctg cctcctccaa gtgcatcaac accgaaggtg gttatgtctg ccggtgctca     2700

gaaggctacc aaggagatgg gattcactgt cttgactcta ctccaccccc tcacctcagg     2760

gaagatgacc accactattc cgtaagaaat agtgactctg aatgtcccct gtcccacgat     2820

gggtactgcc tccatgatgg tgtgtgcatg tatattgaag cattggacaa gtatgcatgc     2880

aactgtgttg ttggctacat cggggagcga tgtcagtacc gagacctgaa gtggtgggaa     2940

ctgcgccacg ctggccacgg gcagcagcag aaggtcatcg tggtggctgt ctgcgtggtg     3000

gtgcttgtca tgctgctcct cctgagcctg tggggggccc actactacag gactcagaag     3060

ctgctatcga aaaacccaaa gaatccttat gaggagtcga gcagagatgt gaggagtcgc     3120

aggcctgctg acactgagga tgggatgtcc tcttgccctc aaccttggtt tgtggttata     3180

aaagaacacc aagacctcaa gaatgggggt caaccagtgg ctggtgagga tggccaggca     3240

gcagatgggt caatgcaacc aacttcatgg aggcaggagc cccagttatg tggaatgggc     3300

acagagcaag gctgctggat tccagtatcc agtgataagg gctcctgtcc ccaggtaatg     3360

gagcgaagct ttcatatgcc ctcctatggg acacagaccc ttgaaggggg tgtcgagaag     3420

ccccattctc tcctatcagc taacccatta tggcaacaaa gggccctgga cccaccacac     3480

caaatggagc tgactcagtg a                                               3501


<210>  14
<211>  1166
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ser Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val 
        915                 920                 925             


Arg Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
    930                 935                 940                 


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
945                 950                 955                 960 


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
                965                 970                 975     


Lys Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val 
            980                 985                 990         


Ile Val Val Ala Val Cys Val Val  Val Leu Val Met Leu  Leu Leu Leu 
        995                 1000                 1005             


Ser Leu  Trp Gly Ala His Tyr  Tyr Arg Thr Gln Lys  Leu Leu Ser 
    1010                 1015                 1020             


Lys Asn  Pro Lys Asn Pro Tyr  Glu Glu Ser Ser Arg  Asp Val Arg 
    1025                 1030                 1035             


Ser Arg  Arg Pro Ala Asp Thr  Glu Asp Gly Met Ser  Ser Cys Pro 
    1040                 1045                 1050             


Gln Pro  Trp Phe Val Val Ile  Lys Glu His Gln Asp  Leu Lys Asn 
    1055                 1060                 1065             


Gly Gly  Gln Pro Val Ala Gly  Glu Asp Gly Gln Ala  Ala Asp Gly 
    1070                 1075                 1080             


Ser Met  Gln Pro Thr Ser Trp  Arg Gln Glu Pro Gln  Leu Cys Gly 
    1085                 1090                 1095             


Met Gly  Thr Glu Gln Gly Cys  Trp Ile Pro Val Ser  Ser Asp Lys 
    1100                 1105                 1110             


Gly Ser  Cys Pro Gln Val Met  Glu Arg Ser Phe His  Met Pro Ser 
    1115                 1120                 1125             


Tyr Gly  Thr Gln Thr Leu Glu  Gly Gly Val Glu Lys  Pro His Ser 
    1130                 1135                 1140             


Leu Leu  Ser Ala Asn Pro Leu  Trp Gln Gln Arg Ala  Leu Asp Pro 
    1145                 1150                 1155             


Pro His  Gln Met Glu Leu Thr  Gln 
    1160                 1165     


<210>  15
<211>  3498
<212>  DNA
<213>  Homo sapiens

<400>  15
atgctgctca ctcttatcat tctgttgcca gtagtttcaa aatttagttt tgttagtctc       60

tcagcaccgc agcactggag ctgtcctgaa ggtactctcg caggaaatgg gaattctact      120

tgtgtgggtc ctgcaccctt cttaattttc tcccatggaa atagtatctt taggattgac      180

acagaaggaa ccaattatga gcaattggtg gtggatgctg gtgtctcagt gatcatggat      240

tttcattata atgagaaaag aatctattgg gtggatttag aaagacaact tttgcaaaga      300

gtttttctga atgggtcaag gcaagagaga gtatgtaata tagagaaaaa tgtttctgga      360

atggcaataa attggataaa tgaagaagtt atttggtcaa atcaacagga aggaatcatt      420

acagtaacag atatgaaagg aaataattcc cacattcttt taagtgcttt aaaatatcct      480

gcaaatgtag cagttgatcc agtagaaagg tttatatttt ggtcttcaga ggtggctgga      540

agcctttata gagcagatct cgatggtgtg ggagtgaagg ctctgttgga gacatcagag      600

aaaataacag ctgtgtcatt ggatgtgctt gataagcggc tgttttggat tcagtacaac      660

agagaaggaa gcaattctct tatttgctcc tgtgattatg atggaggttc tgtccacatt      720

agtaaacatc caacacagca taatttgttt gcaatgtccc tttttggtga ccgtatcttc      780

tattcaacat ggaaaatgaa gacaatttgg atagccaaca aacacactgg aaaggacatg      840

gttagaatta acctccattc atcatttgta ccacttggtg aactgaaagt agtgcatcca      900

cttgcacaac ccaaggcaga agatgacact tgggagcctg atgttaatga atgtgctttt      960

tggaatcatg gctgtactct tgggtgtaaa aacacccctg gatcctatta ctgcacgtgc     1020

cctgtaggat ttgttctgct tcctgatggg aaacgatgtc atcaacttgt ttcctgtcca     1080

cgcaatgtgt ctgaatgcag ccatgactgt gttctgacat cagaaggtcc cttatgtttc     1140

tgtcctgaag gctcagtgct tgagagagat gggaaaacat gtagcggttg ttcctcaccc     1200

gataatggtg gatgtagcca gctctgcgtt cctcttagcc cagtatcctg ggaatgtgat     1260

tgctttcctg ggtatgacct acaactggat gaaaaaagct gtgcagcttc aggaccacaa     1320

ccatttttgc tgtttgccaa ttctcaagat attcgacaca tgcattttga tggaacagac     1380

tatggaactc tgctcagcca gcagatggga atggtttatg ccctagatca tgaccctgtg     1440

gaaaataaga tatactttgc ccatacagcc ctgaagtgga tagagagagc taatatggat     1500

ggttcccagc gagaaaggct tattgaggaa ggagtagatg tgccagaagg tcttgctgtg     1560

gactggattg gccgtagatt ctattggaca gacagaggga aatctctgat tggaaggagt     1620

gatttaaatg ggaaacgttc caaaataatc actaaggaga acatctctca accacgagga     1680

attgctgttc atccaatggc caagagatta ttctggactg atacagggat taatccacga     1740

attgaaagtt cttccctcca aggccttggc cgtctggtta tagccagctc tgatctaatc     1800

tggcccagtg gaataacgat tgacttctta actgacaagt tgtactggtg cgatgccaag     1860

cagtctgtga ttgaaatggc caatctggat ggttcaaaac gccgaagact tacccagaat     1920

gatgtaggtc acccatttgc tgtagcagtg tttgaggatt atgtgtggtt ctcagattgg     1980

gctatgccat cagtaatgag agtaaacaag aggactggca aagatagagt acgtctccaa     2040

ggcagcatgc tgaagccctc atcactggtt gtggttcatc cattggcaaa accaggagca     2100

gatccctgct tatatcaaaa cggaggctgt gaacatattt gcaaaaagag gcttggaact     2160

gcttggtgtt cgtgtcgtga aggttttatg aaagcctcag atgggaaaac gtgtctggct     2220

ctggatggtc atcagctgtt ggcaggtggt gaagttgatc taaagaacca agtaacacca     2280

ttggacatct tgtccaagac tagagtgtca gaagataaca ttacagaatc tcaacacatg     2340

ctagtggctg aaatcatggt gtcagatcaa gatgactgtg ctcctgtggg atgcagcatg     2400

tatgctcggt gtatttcaga gggagaggat gccacatgtc agtgtttgaa aggatttgct     2460

ggggatggaa aactatgttc tgatatagat gaatgtgaga tgggtgtccc agtgtgcccc     2520

cctgcctcct ccaagtgcat caacaccgaa ggtggttatg tctgccggtg ctcagaaggc     2580

taccaaggag atgggattca ctgtcttgat attgatgagt gccaactggg ggagcacagc     2640

tgtggagaga atgccagctg cacaaataca gagggaggct atacctgcat gtgtgctgga     2700

cgcctgtctg aaccaggact gatttgccct gactctactc caccccctca cctcagggaa     2760

gatgaccacc actattccgt aagaaatagt gactctgaat gtcccctgtc ccacgatggg     2820

tactgcctcc atgatggtgt gtgcatgtat attgaagcat tggacaagta tgcatgcaac     2880

tgtgttgttg gctacatcgg ggagcgatgt cagtaccgag acctgaagtg gtgggaactg     2940

cgccacgctg gccacgggca gcagcagaag gtcatcgtgg tggctgtctg cgtggtggtg     3000

cttgtcatgc tgctcctcct gagcctgtgg ggggcccact actacaggac tcagaagctg     3060

ctatcgaaaa acccaaagaa tccttatgag gagtcgagca gagatgtgag gagtcgcagg     3120

cctgctgaca ctgaggatgg gatgtcctct tgccctcaac cttggtttgt ggttataaaa     3180

gaacaccaag acctcaagaa tgggggtcaa ccagtggctg gtgaggatgg ccaggcagca     3240

gatgggtcaa tgcaaccaac ttcatggagg caggagcccc agttatgtgg aatgggcaca     3300

gagcaaggct gctggattcc agtatccagt gataagggct cctgtcccca ggtaatggag     3360

cgaagctttc atatgccctc ctatgggaca cagacccttg aagggggtgt cgagaagccc     3420

cattctctcc tatcagctaa cccattatgg caacaaaggg ccctggaccc accacaccaa     3480

atggagctga ctcagtga                                                   3498


<210>  16
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Asp Val Asn Glu Cys Ala Phe 
305                 310                 315                 320 


Trp Asn His Gly Cys Thr Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr 
                325                 330                 335     


Tyr Cys Thr Cys Pro Val Gly Phe Val Leu Leu Pro Asp Gly Lys Arg 
            340                 345                 350         


Cys His Gln Leu Val Ser Cys Pro Arg Asn Val Ser Glu Cys Ser His 
        355                 360                 365             


Asp Cys Val Leu Thr Ser Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly 
    370                 375                 380                 


Ser Val Leu Glu Arg Asp Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro 
385                 390                 395                 400 


Asp Asn Gly Gly Cys Ser Gln Leu Cys Val Pro Leu Ser Pro Val Ser 
                405                 410                 415     


Trp Glu Cys Asp Cys Phe Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys 
            420                 425                 430         


Ser Cys Ala Ala Ser Gly Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser 
        435                 440                 445             


Gln Asp Ile Arg His Met His Phe Asp Gly Thr Asp Tyr Gly Thr Leu 
    450                 455                 460                 


Leu Ser Gln Gln Met Gly Met Val Tyr Ala Leu Asp His Asp Pro Val 
465                 470                 475                 480 


Glu Asn Lys Ile Tyr Phe Ala His Thr Ala Leu Lys Trp Ile Glu Arg 
                485                 490                 495     


Ala Asn Met Asp Gly Ser Gln Arg Glu Arg Leu Ile Glu Glu Gly Val 
            500                 505                 510         


Asp Val Pro Glu Gly Leu Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr 
        515                 520                 525             


Trp Thr Asp Arg Gly Lys Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly 
    530                 535                 540                 


Lys Arg Ser Lys Ile Ile Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly 
545                 550                 555                 560 


Ile Ala Val His Pro Met Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly 
                565                 570                 575     


Ile Asn Pro Arg Ile Glu Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu 
            580                 585                 590         


Val Ile Ala Ser Ser Asp Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp 
        595                 600                 605             


Phe Leu Thr Asp Lys Leu Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile 
    610                 615                 620                 


Glu Met Ala Asn Leu Asp Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn 
625                 630                 635                 640 


Asp Val Gly His Pro Phe Ala Val Ala Val Phe Glu Asp Tyr Val Trp 
                645                 650                 655     


Phe Ser Asp Trp Ala Met Pro Ser Val Met Arg Val Asn Lys Arg Thr 
            660                 665                 670         


Gly Lys Asp Arg Val Arg Leu Gln Gly Ser Met Leu Lys Pro Ser Ser 
        675                 680                 685             


Leu Val Val Val His Pro Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu 
    690                 695                 700                 


Tyr Gln Asn Gly Gly Cys Glu His Ile Cys Lys Lys Arg Leu Gly Thr 
705                 710                 715                 720 


Ala Trp Cys Ser Cys Arg Glu Gly Phe Met Lys Ala Ser Asp Gly Lys 
                725                 730                 735     


Thr Cys Leu Ala Leu Asp Gly His Gln Leu Leu Ala Gly Gly Glu Val 
            740                 745                 750         


Asp Leu Lys Asn Gln Val Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg 
        755                 760                 765             


Val Ser Glu Asp Asn Ile Thr Glu Ser Gln His Met Leu Val Ala Glu 
    770                 775                 780                 


Ile Met Val Ser Asp Gln Asp Asp Cys Ala Pro Val Gly Cys Ser Met 
785                 790                 795                 800 


Tyr Ala Arg Cys Ile Ser Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu 
                805                 810                 815     


Lys Gly Phe Ala Gly Asp Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys 
            820                 825                 830         


Glu Met Gly Val Pro Val Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn 
        835                 840                 845             


Thr Glu Gly Gly Tyr Val Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp 
    850                 855                 860                 


Gly Ile His Cys Leu Asp Ile Asp Glu Cys Gln Leu Gly Glu His Ser 
865                 870                 875                 880 


Cys Gly Glu Asn Ala Ser Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys 
                885                 890                 895     


Met Cys Ala Gly Arg Leu Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser 
            900                 905                 910         


Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val Arg 
        915                 920                 925             


Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
    930                 935                 940                 


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
945                 950                 955                 960 


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
                965                 970                 975     


Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val Ile 
            980                 985                 990         


Val Val Ala Val Cys Val Val Val  Leu Val Met Leu Leu  Leu Leu Ser 
        995                 1000                 1005             


Leu Trp  Gly Ala His Tyr Tyr  Arg Thr Gln Lys Leu  Leu Ser Lys 
    1010                 1015                 1020             


Asn Pro  Lys Asn Pro Tyr Glu  Glu Ser Ser Arg Asp  Val Arg Ser 
    1025                 1030                 1035             


Arg Arg  Pro Ala Asp Thr Glu  Asp Gly Met Ser Ser  Cys Pro Gln 
    1040                 1045                 1050             


Pro Trp  Phe Val Val Ile Lys  Glu His Gln Asp Leu  Lys Asn Gly 
    1055                 1060                 1065             


Gly Gln  Pro Val Ala Gly Glu  Asp Gly Gln Ala Ala  Asp Gly Ser 
    1070                 1075                 1080             


Met Gln  Pro Thr Ser Trp Arg  Gln Glu Pro Gln Leu  Cys Gly Met 
    1085                 1090                 1095             


Gly Thr  Glu Gln Gly Cys Trp  Ile Pro Val Ser Ser  Asp Lys Gly 
    1100                 1105                 1110             


Ser Cys  Pro Gln Val Met Glu  Arg Ser Phe His Met  Pro Ser Tyr 
    1115                 1120                 1125             


Gly Thr  Gln Thr Leu Glu Gly  Gly Val Glu Lys Pro  His Ser Leu 
    1130                 1135                 1140             


Leu Ser  Ala Asn Pro Leu Trp  Gln Gln Arg Ala Leu  Asp Pro Pro 
    1145                 1150                 1155             


His Gln  Met Glu Leu Thr Gln  
    1160                 1165 


<210>  17
<211>  3654
<212>  DNA
<213>  Mus musculus

<400>  17
atgccctggg gccgaaggcc aacctggctg ttgctcgcct tcctgctggt gtttttaaag       60

attagcatac tcagcgtcac agcatggcag accgggaact gtcagccagg tcctctcgag      120

agaagcgaga gaagcgggac ttgtgccggt cctgccccct tcctagtttt ctcacaagga      180

aagagcatct ctcggattga cccagatgga acaaatcacc agcaattggt ggtggatgct      240

ggcatctcag cagacatgga tattcattat aaaaaagaga gactctattg ggtggatgta      300

gaaagacaag ttttgctaag agttttcctt aacgggacag gactagagaa agtgtgcaat      360

gtagagagga aggtgtctgg gctggccata gactggatag atgatgaagt tctctgggta      420

gaccaacaga acggagtcat caccgtaaca gatatgacag ggaaaaattc ccgagttctt      480

ctaagttcct taaaacatcc gtcaaatata gcagtggatc caatagagag gttgatgttt      540

tggtcttcag aggtgaccgg cagccttcac agagcacacc tcaaaggtgt tgatgtaaaa      600

acactgctgg agacaggggg aatatcggtg ctgactctgg atgtcctgga caaacggctc      660

ttctgggttc aggacagtgg cgaaggaagc cacgcttaca ttcattcctg tgattatgag      720

ggtggctccg tccgtcttat caggcatcaa gcacggcaca gtttgtcttc aatggccttt      780

tttggtgatc ggatcttcta ctcagtgttg aaaagcaagg cgatttggat agccaacaaa      840

cacacgggga aggacacggt caggattaac ctccatccat cctttgtgac acctggaaaa      900

ctgatggtag tacaccctcg tgcacagccc aggacagagg acgctgctaa ggatcctgac      960

cccgaacttc tcaaacagag gggaagacca tgccgcttcg gtctctgtga gcgagacccc     1020

aagtcccact cgagcgcatg cgctgagggc tacacgttaa gccgagaccg gaagtactgc     1080

gaagatgtca atgaatgtgc cactcagaat cacggctgta ctcttgggtg tgaaaacacc     1140

cctggatcct atcactgcac atgccccaca ggatttgttc tgcttcctga tgggaaacaa     1200

tgtcacgaac ttgtttcctg cccaggcaac gtatcaaagt gcagtcatgg ctgtgtcctg     1260

acatcagatg gtccccggtg catctgtcct gcaggttcag tgcttgggag agatgggaag     1320

acttgcactg gttgttcatc gcctgacaat ggtggatgca gccagatctg tcttcctctc     1380

aggccaggat cctgggaatg tgattgcttt cctgggtatg acctacagtc agaccgaaag     1440

agctgtgcag cttcaggacc acagccactt ttactgtttg caaattccca ggacatccga     1500

cacatgcatt ttgatggaac agactacaaa gttctgctca gccggcagat gggaatggtt     1560

tttgccttgg attatgaccc tgtggaaagc aagatatatt ttgcacagac agccctgaag     1620

tggatagaga gggctaatat ggatgggtcc cagcgagaaa gactgatcac agaaggagta     1680

gatacgcttg aaggtcttgc cctggactgg attggccgga gaatctactg gacagacagt     1740

gggaagtctg ttgttggagg gagcgatctg agcgggaagc atcatcgaat aatcatccag     1800

gagagaatct cgaggccgcg aggaatagct gtgcatccaa gggccaggag actgttctgg     1860

acggacgtag ggatgtctcc acggattgaa agcgcttccc ttcaaggttc cgaccgggtg     1920

ctgatagcca gctccaatct actggaaccc agtggaatca cgattgacta cttaacagac     1980

actttgtact ggtgtgacac caagaggtct gtgattgaaa tggccaatct ggatggctcc     2040

aaacgccgaa gacttatcca gaacgacgta ggtcacccct tctctctagc cgtgtttgag     2100

gatcacctgt gggtctcgga ttgggctatc ccatcggtaa taagggtgaa caagaggact     2160

ggccaaaaca gggtacgtct tcaaggcagc atgctgaagc cctcgtcact ggttgtggtc     2220

catccattgg caaaaccagg tgcagatccc tgcttataca ggaatggagg ctgtgaacac     2280

atctgccaag agagcctggg cacagctcgg tgtttgtgtc gtgaaggttt tgtgaaggcc     2340

tgggatggga aaatgtgtct ccctcaggat tatccaatcc tgtcaggtga aaatgctgat     2400

cttagtaaag aggtgacatc actgagcaac tccactcagg ctgaagtacc agacgatgat     2460

gggacagaat cttccacact agtggctgaa atcatggtgt caggcatgaa ctatgaagat     2520

gactgtggtc ccggggggtg tggaagccat gctcgatgcg tttcagacgg agagactgct     2580

gagtgtcagt gtctgaaagg gtttgccagg gatggaaacc tgtgttctga tatagatgag     2640

tgtgtgctgg ctagatcgga ctgccccagc acctcgtcca ggtgcatcaa cactgaaggt     2700

ggctacgtct gcagatgctc agaaggctac gaaggagacg ggatctcctg tttcgatatt     2760

gacgagtgcc agcggggggc gcacaactgc ggtgagaatg ccgcctgcac caacacggag     2820

ggaggctaca actgcacctg cgcaggccgc ccatcctcgc ccggactgag ttgccctgac     2880

tctaccgcac cctctctcct tggggaagat ggccaccatt tggaccgaaa tagttatcca     2940

ggatgcccat cctcatatga tggatactgc ctcaatggtg gcgtgtgcat gcatattgaa     3000

tcactggaca gctacacatg caactgtgtt attggctatt ctggggatcg atgccagact     3060

cgagacctac gatggtggga actgcgtcat gctggctacg ggcagaagca tgacatcatg     3120

gtggtggctg tctgcatggt ggcactggtc ctgctgctcg tcttggggat gtgggggact     3180

tactactaca ggactcggaa gcagctatca aaccccccaa agaacccttg tgatgagcca     3240

agcggaagtg tgagcagcag cggacccaac agcagcagcg gggcagctgt ggcttcttgt     3300

ccccaacctt ggtttgtggt cctagagaaa caccaagacc ccaagaatgg gagtctgcct     3360

gcggatggta cgaatggtgc agtagtagat gctggcctgt ctccctccct gcagctcggg     3420

tcagtgcatc tgacttcatg gagacagaag ccccacatag atggaatggg cacagggcaa     3480

agctgctgga ttccaccatc aagtgacaga ggaccccagg aaatagaggg aaactcccac     3540

ctaccctcct acagacctgt ggggccggag aagctgcatt ctctccagtc agctaatgga     3600

tcgtgtcacg aaagggctcc agacctgcca cggcagacag agccagttca gtag           3654


<210>  18
<211>  1217
<212>  PRT
<213>  Mus musculus

<400>  18

Met Pro Trp Gly Arg Arg Pro Thr Trp Leu Leu Leu Ala Phe Leu Leu 
1               5                   10                  15      


Val Phe Leu Lys Ile Ser Ile Leu Ser Val Thr Ala Trp Gln Thr Gly 
            20                  25                  30          


Asn Cys Gln Pro Gly Pro Leu Glu Arg Ser Glu Arg Ser Gly Thr Cys 
        35                  40                  45              


Ala Gly Pro Ala Pro Phe Leu Val Phe Ser Gln Gly Lys Ser Ile Ser 
    50                  55                  60                  


Arg Ile Asp Pro Asp Gly Thr Asn His Gln Gln Leu Val Val Asp Ala 
65                  70                  75                  80  


Gly Ile Ser Ala Asp Met Asp Ile His Tyr Lys Lys Glu Arg Leu Tyr 
                85                  90                  95      


Trp Val Asp Val Glu Arg Gln Val Leu Leu Arg Val Phe Leu Asn Gly 
            100                 105                 110         


Thr Gly Leu Glu Lys Val Cys Asn Val Glu Arg Lys Val Ser Gly Leu 
        115                 120                 125             


Ala Ile Asp Trp Ile Asp Asp Glu Val Leu Trp Val Asp Gln Gln Asn 
    130                 135                 140                 


Gly Val Ile Thr Val Thr Asp Met Thr Gly Lys Asn Ser Arg Val Leu 
145                 150                 155                 160 


Leu Ser Ser Leu Lys His Pro Ser Asn Ile Ala Val Asp Pro Ile Glu 
                165                 170                 175     


Arg Leu Met Phe Trp Ser Ser Glu Val Thr Gly Ser Leu His Arg Ala 
            180                 185                 190         


His Leu Lys Gly Val Asp Val Lys Thr Leu Leu Glu Thr Gly Gly Ile 
        195                 200                 205             


Ser Val Leu Thr Leu Asp Val Leu Asp Lys Arg Leu Phe Trp Val Gln 
    210                 215                 220                 


Asp Ser Gly Glu Gly Ser His Ala Tyr Ile His Ser Cys Asp Tyr Glu 
225                 230                 235                 240 


Gly Gly Ser Val Arg Leu Ile Arg His Gln Ala Arg His Ser Leu Ser 
                245                 250                 255     


Ser Met Ala Phe Phe Gly Asp Arg Ile Phe Tyr Ser Val Leu Lys Ser 
            260                 265                 270         


Lys Ala Ile Trp Ile Ala Asn Lys His Thr Gly Lys Asp Thr Val Arg 
        275                 280                 285             


Ile Asn Leu His Pro Ser Phe Val Thr Pro Gly Lys Leu Met Val Val 
    290                 295                 300                 


His Pro Arg Ala Gln Pro Arg Thr Glu Asp Ala Ala Lys Asp Pro Asp 
305                 310                 315                 320 


Pro Glu Leu Leu Lys Gln Arg Gly Arg Pro Cys Arg Phe Gly Leu Cys 
                325                 330                 335     


Glu Arg Asp Pro Lys Ser His Ser Ser Ala Cys Ala Glu Gly Tyr Thr 
            340                 345                 350         


Leu Ser Arg Asp Arg Lys Tyr Cys Glu Asp Val Asn Glu Cys Ala Thr 
        355                 360                 365             


Gln Asn His Gly Cys Thr Leu Gly Cys Glu Asn Thr Pro Gly Ser Tyr 
    370                 375                 380                 


His Cys Thr Cys Pro Thr Gly Phe Val Leu Leu Pro Asp Gly Lys Gln 
385                 390                 395                 400 


Cys His Glu Leu Val Ser Cys Pro Gly Asn Val Ser Lys Cys Ser His 
                405                 410                 415     


Gly Cys Val Leu Thr Ser Asp Gly Pro Arg Cys Ile Cys Pro Ala Gly 
            420                 425                 430         


Ser Val Leu Gly Arg Asp Gly Lys Thr Cys Thr Gly Cys Ser Ser Pro 
        435                 440                 445             


Asp Asn Gly Gly Cys Ser Gln Ile Cys Leu Pro Leu Arg Pro Gly Ser 
    450                 455                 460                 


Trp Glu Cys Asp Cys Phe Pro Gly Tyr Asp Leu Gln Ser Asp Arg Lys 
465                 470                 475                 480 


Ser Cys Ala Ala Ser Gly Pro Gln Pro Leu Leu Leu Phe Ala Asn Ser 
                485                 490                 495     


Gln Asp Ile Arg His Met His Phe Asp Gly Thr Asp Tyr Lys Val Leu 
            500                 505                 510         


Leu Ser Arg Gln Met Gly Met Val Phe Ala Leu Asp Tyr Asp Pro Val 
        515                 520                 525             


Glu Ser Lys Ile Tyr Phe Ala Gln Thr Ala Leu Lys Trp Ile Glu Arg 
    530                 535                 540                 


Ala Asn Met Asp Gly Ser Gln Arg Glu Arg Leu Ile Thr Glu Gly Val 
545                 550                 555                 560 


Asp Thr Leu Glu Gly Leu Ala Leu Asp Trp Ile Gly Arg Arg Ile Tyr 
                565                 570                 575     


Trp Thr Asp Ser Gly Lys Ser Val Val Gly Gly Ser Asp Leu Ser Gly 
            580                 585                 590         


Lys His His Arg Ile Ile Ile Gln Glu Arg Ile Ser Arg Pro Arg Gly 
        595                 600                 605             


Ile Ala Val His Pro Arg Ala Arg Arg Leu Phe Trp Thr Asp Val Gly 
    610                 615                 620                 


Met Ser Pro Arg Ile Glu Ser Ala Ser Leu Gln Gly Ser Asp Arg Val 
625                 630                 635                 640 


Leu Ile Ala Ser Ser Asn Leu Leu Glu Pro Ser Gly Ile Thr Ile Asp 
                645                 650                 655     


Tyr Leu Thr Asp Thr Leu Tyr Trp Cys Asp Thr Lys Arg Ser Val Ile 
            660                 665                 670         


Glu Met Ala Asn Leu Asp Gly Ser Lys Arg Arg Arg Leu Ile Gln Asn 
        675                 680                 685             


Asp Val Gly His Pro Phe Ser Leu Ala Val Phe Glu Asp His Leu Trp 
    690                 695                 700                 


Val Ser Asp Trp Ala Ile Pro Ser Val Ile Arg Val Asn Lys Arg Thr 
705                 710                 715                 720 


Gly Gln Asn Arg Val Arg Leu Gln Gly Ser Met Leu Lys Pro Ser Ser 
                725                 730                 735     


Leu Val Val Val His Pro Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu 
            740                 745                 750         


Tyr Arg Asn Gly Gly Cys Glu His Ile Cys Gln Glu Ser Leu Gly Thr 
        755                 760                 765             


Ala Arg Cys Leu Cys Arg Glu Gly Phe Val Lys Ala Trp Asp Gly Lys 
    770                 775                 780                 


Met Cys Leu Pro Gln Asp Tyr Pro Ile Leu Ser Gly Glu Asn Ala Asp 
785                 790                 795                 800 


Leu Ser Lys Glu Val Thr Ser Leu Ser Asn Ser Thr Gln Ala Glu Val 
                805                 810                 815     


Pro Asp Asp Asp Gly Thr Glu Ser Ser Thr Leu Val Ala Glu Ile Met 
            820                 825                 830         


Val Ser Gly Met Asn Tyr Glu Asp Asp Cys Gly Pro Gly Gly Cys Gly 
        835                 840                 845             


Ser His Ala Arg Cys Val Ser Asp Gly Glu Thr Ala Glu Cys Gln Cys 
    850                 855                 860                 


Leu Lys Gly Phe Ala Arg Asp Gly Asn Leu Cys Ser Asp Ile Asp Glu 
865                 870                 875                 880 


Cys Val Leu Ala Arg Ser Asp Cys Pro Ser Thr Ser Ser Arg Cys Ile 
                885                 890                 895     


Asn Thr Glu Gly Gly Tyr Val Cys Arg Cys Ser Glu Gly Tyr Glu Gly 
            900                 905                 910         


Asp Gly Ile Ser Cys Phe Asp Ile Asp Glu Cys Gln Arg Gly Ala His 
        915                 920                 925             


Asn Cys Gly Glu Asn Ala Ala Cys Thr Asn Thr Glu Gly Gly Tyr Asn 
    930                 935                 940                 


Cys Thr Cys Ala Gly Arg Pro Ser Ser Pro Gly Leu Ser Cys Pro Asp 
945                 950                 955                 960 


Ser Thr Ala Pro Ser Leu Leu Gly Glu Asp Gly His His Leu Asp Arg 
                965                 970                 975     


Asn Ser Tyr Pro Gly Cys Pro Ser Ser Tyr Asp Gly Tyr Cys Leu Asn 
            980                 985                 990         


Gly Gly Val Cys Met His Ile Glu  Ser Leu Asp Ser Tyr  Thr Cys Asn 
        995                 1000                 1005             


Cys Val  Ile Gly Tyr Ser Gly  Asp Arg Cys Gln Thr  Arg Asp Leu 
    1010                 1015                 1020             


Arg Trp  Trp Glu Leu Arg His  Ala Gly Tyr Gly Gln  Lys His Asp 
    1025                 1030                 1035             


Ile Met  Val Val Ala Val Cys  Met Val Ala Leu Val  Leu Leu Leu 
    1040                 1045                 1050             


Val Leu  Gly Met Trp Gly Thr  Tyr Tyr Tyr Arg Thr  Arg Lys Gln 
    1055                 1060                 1065             


Leu Ser  Asn Pro Pro Lys Asn  Pro Cys Asp Glu Pro  Ser Gly Ser 
    1070                 1075                 1080             


Val Ser  Ser Ser Gly Pro Asn  Ser Ser Ser Gly Ala  Ala Val Ala 
    1085                 1090                 1095             


Ser Cys  Pro Gln Pro Trp Phe  Val Val Leu Glu Lys  His Gln Asp 
    1100                 1105                 1110             


Pro Lys  Asn Gly Ser Leu Pro  Ala Asp Gly Thr Asn  Gly Ala Val 
    1115                 1120                 1125             


Val Asp  Ala Gly Leu Ser Pro  Ser Leu Gln Leu Gly  Ser Val His 
    1130                 1135                 1140             


Leu Thr  Ser Trp Arg Gln Lys  Pro His Ile Asp Gly  Met Gly Thr 
    1145                 1150                 1155             


Gly Gln  Ser Cys Trp Ile Pro  Pro Ser Ser Asp Arg  Gly Pro Gln 
    1160                 1165                 1170             


Glu Ile  Glu Gly Asn Ser His  Leu Pro Ser Tyr Arg  Pro Val Gly 
    1175                 1180                 1185             


Pro Glu  Lys Leu His Ser Leu  Gln Ser Ala Asn Gly  Ser Cys His 
    1190                 1195                 1200             


Glu Arg  Ala Pro Asp Leu Pro  Arg Gln Thr Glu Pro  Val Gln 
    1205                 1210                 1215         


<210>  19
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  19
atgaagctgc tgccgtcggt ggtgctgaag ctctttctgg ctgcagttct ctcggcactg       60

gtgactggcg agagcctgga gcggcttcgg agagggctag ctgctggaac cagcaacccg      120

gaccctccca ctgtatccac ggaccagctg ctacccctag gaggcggccg ggaccggaaa      180

gtccgtgact tgcaagaggc agatctggac cttttgagag tcactttatc ctccaagcca      240

caagcactgg ccacaccaaa caaggaggag cacgggaaaa gaaagaagaa aggcaagggg      300

ctagggaaga agagggaccc atgtcttcgg aaatacaagg acttctgcat ccatggagaa      360

tgcaaatatg tgaaggagct ccgggctccc tcctgcatct gccacccggg ttaccatgga      420

gagaggtgtc atgggctgag cctcccagtg gaaaatcgct tatataccta tgaccacaca      480

accatcctgg ccgtggtggc tgtggtgctg tcatctgtct gtctgctggt catcgtgggg      540

cttctcatgt ttaggtacca taggagagga ggttatgatg tggaaaatga agagaaagtg      600

aagttgggca tgactaattc ccactga                                          627


<210>  20
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  21
<211>  627
<212>  DNA
<213>  Mus musculus

<400>  21
atgaagctgc tgccgtcggt gatgctgaag ctctttctgg ccgcagtgtt gtccgcgttg       60

gtgaccggtg agagtctgga gcggcttcgg agaggtctgg cggcagcaac cagcaaccct      120

gaccctccca ctggatccac aaaccagctg ctacccacgg gaggtgatcg tgctcagggg      180

gtccaggact tggaagggac agatctgaac cttttcaaag ttgctttctc ctccaagcca      240

caaggcctgg ccaccccaag caaagaaagg aatgggaaaa agaagaagaa aggaaagggg      300

ttagggaaga agagagaccc atgcctcagg aaatacaagg actactgcat ccacggggag      360

tgcagatacc tgcaggagtt ccgtactccc tcttgcaaat gcctccctgg ttaccacgga      420

cacaggtgtc atgggctgac tctaccagtg gagaatcccc tatacacata tgaccacact      480

acagtcttgg ctgtggtggc tgtagtactg tcgtccgtct gtcttcttgt catcgtggga      540

cttctcatgt ttaggtacca caggagagga ggttatgact tggaaagtga agagaaagtg      600

aagttgggcg tggctagctc ccactga                                          627


<210>  22
<211>  208
<212>  PRT
<213>  Mus musculus

<400>  22

Met Lys Leu Leu Pro Ser Val Met Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Ala Thr Ser Asn Pro Asp Pro Pro Thr Gly Ser Thr Asn 
        35                  40                  45              


Gln Leu Leu Pro Thr Gly Gly Asp Arg Ala Gln Gly Val Gln Asp Leu 
    50                  55                  60                  


Glu Gly Thr Asp Leu Asn Leu Phe Lys Val Ala Phe Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Gly Leu Ala Thr Pro Ser Lys Glu Arg Asn Gly Lys Lys Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Tyr Cys Ile His Gly Glu Cys Arg Tyr Leu Gln Glu Phe Arg 
        115                 120                 125             


Thr Pro Ser Cys Lys Cys Leu Pro Gly Tyr His Gly His Arg Cys His 
    130                 135                 140                 


Gly Leu Thr Leu Pro Val Glu Asn Pro Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Val Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Leu Glu Ser Glu Glu Lys Val Lys Leu Gly Val Ala Ser Ser His 
        195                 200                 205             


<210>  23
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  23
atggctttgg gagttccaat atcagtctat cttttattca acgcaatgac agcactgacc       60

gaagaggcag ccgtgactgt aacacctcca atcacagccc agcaaggtaa ctggacagtt      120

aacaaaacag aagctgacaa catagaagga cccatagcct tgaagttctc acacctttgc      180

ctggaagatc ataacagtta ctgcatcaac ggtgcttgtg cattccacca tgagctagag      240

aaagccatct gcaggtgttt tactggttat actggagaaa ggtgtgagca cttgacttta      300

acttcatatg ctgtggattc ttatgaaaaa tacattgcaa ttgggattgg tgttggatta      360

ctattaagtg gttttcttgt tattttttac tgctatataa gaaagaggtg tctaaaattg      420

aaatcgcctt acaatgtctg ttctggagaa agacgaccac tgtga                      465


<210>  24
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu 
                85                  90                  95      


His Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile 
            100                 105                 110         


Ala Ile Gly Ile Gly Val Gly Leu Leu Leu Ser Gly Phe Leu Val Ile 
        115                 120                 125             


Phe Tyr Cys Tyr Ile Arg Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr 
    130                 135                 140                 


Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
145                 150                 


<210>  25
<211>  459
<212>  DNA
<213>  Mus musculus

<400>  25
atggctctgg gggttctgat agcagtctgc ctcttgttca aagcaatgaa ggcagcactg       60

agcgaagaag cagaggtgat ccctcctagc acagcacagc agagcaactg gacatttaac      120

aacaccgaag ctgactacat agaagaacct gtagctctga agttctctca tccttgtctg      180

gaagaccata atagttactg cattaatgga gcatgtgcat tccaccatga gctgaagcaa      240

gccatttgca gatgctttac tggttatacg ggacaacgat gtgagcattt gaccctaact      300

tcgtatgctg tggattctta tgaaaaatac attgcgattg ggattggcgt cggattgcta      360

attagtgctt ttcttgctgt cttctattgc tacataagaa aaaggtgtat aaatctgaaa      420

tcaccctaca tcatctgctc tggagggagc ccattgtga                             459


<210>  26
<211>  152
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ala Leu Gly Val Leu Ile Ala Val Cys Leu Leu Phe Lys Ala Met 
1               5                   10                  15      


Lys Ala Ala Leu Ser Glu Glu Ala Glu Val Ile Pro Pro Ser Thr Ala 
            20                  25                  30          


Gln Gln Ser Asn Trp Thr Phe Asn Asn Thr Glu Ala Asp Tyr Ile Glu 
        35                  40                  45              


Glu Pro Val Ala Leu Lys Phe Ser His Pro Cys Leu Glu Asp His Asn 
    50                  55                  60                  


Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Lys Gln 
65                  70                  75                  80  


Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Gln Arg Cys Glu His 
                85                  90                  95      


Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile Ala 
            100                 105                 110         


Ile Gly Ile Gly Val Gly Leu Leu Ile Ser Ala Phe Leu Ala Val Phe 
        115                 120                 125             


Tyr Cys Tyr Ile Arg Lys Arg Cys Ile Asn Leu Lys Ser Pro Tyr Ile 
    130                 135                 140                 


Ile Cys Ser Gly Gly Ser Pro Leu 
145                 150         


<210>  27
<211>  759
<212>  DNA
<213>  Homo sapiens

<400>  27
atgagagccc cgctgctacc gccggcgccg gtggtgctgt cgctcttgat actcggctca       60

ggccattatg ctgctggatt ggacctcaat gacacctact ctgggaagcg tgaaccattt      120

tctggggacc acagtgctga tggatttgag gttacctcaa gaagtgagat gtcttcaggg      180

agtgagattt cccctgtgag tgaaatgcct tctagtagtg aaccgtcctc gggagccgac      240

tatgactact cagaagagta tgataacgaa ccacaaatac ctggctatat tgtcgatgat      300

tcagtcagag ttgaacaggt agttaagccc ccccaaaaca agacggaaag tgaaaatact      360

tcagataaac ccaaaagaaa gaaaaaggga ggcaaaaatg gaaaaaatag aagaaacaga      420

aagaagaaaa atccatgtaa tgcagaattt caaaatttct gcattcacgg agaatgcaaa      480

tatatagagc acctggaagc agtaacatgc aaatgtcagc aagaatattt cggtgaacgg      540

tgtggggaaa agtccatgaa aactcacagc atgattgaca gtagtttatc aaaaattgca      600

ttagcagcca tagctgcctt tatgtctgct gtgatcctca cagctgttgc tgttattaca      660

gtccagctta gaagacaata cgtcaggaaa tatgaaggag aagctgagga acgaaagaaa      720

cttcgacaag agaatggaaa tgtacatgct atagcataa                             759


<210>  28
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210>  29
<211>  747
<212>  DNA
<213>  Mus musculus

<400>  29
atgagaactc cgctgctacc gctggcgcgc tcagtgctgt tgctgctggt cttaggctca       60

ggccattatg cagctgcttt ggagctcaat gaccccagct cagggaaagg cgaatcgctt      120

tctggggacc acagtgccgg tggacttgag ctttctgtgg gaagagaggt ttccaccata      180

agcgaaatgc cttctggcag tgaactctcc acaggggact acgactactc agaggagtat      240

gataatgaac cacaaatatc cggctatatt atagatgatt cagtcagagt tgaacaggtg      300

attaagccca agaaaaacaa gacagaagga gaaaagtcta cagaaaaacc caaaaggaag      360

aaaaagggag gcaaaaatgg aaaaggcaga aggaataaga agaaaaagaa tccatgcact      420

gccaagtttc agaacttttg cattcatggc gaatgcagat acatcgagaa cctggaggtg      480

gtgacatgca attgtcatca agattacttt ggtgaacggt gtggagaaaa atccatgaag      540

actcacagcg aggatgacaa ggacctatcc aagattgcag tagtagctgt cactatcttt      600

gtctctgcca tcatcctcgc agctattggc atcggcatcg ttatcacagt gcacctttgg      660

aaacgatact tcagggaata tgaaggagaa acagaagaaa gaaggaggct tcgacaagaa      720

aacgggactg tgcatgccat tgcctag                                          747


<210>  30
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  30

Met Arg Thr Pro Leu Leu Pro Leu Ala Arg Ser Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Gly Ser Gly His Tyr Ala Ala Ala Leu Glu Leu Asn Asp Pro 
            20                  25                  30          


Ser Ser Gly Lys Gly Glu Ser Leu Ser Gly Asp His Ser Ala Gly Gly 
        35                  40                  45              


Leu Glu Leu Ser Val Gly Arg Glu Val Ser Thr Ile Ser Glu Met Pro 
    50                  55                  60                  


Ser Gly Ser Glu Leu Ser Thr Gly Asp Tyr Asp Tyr Ser Glu Glu Tyr 
65                  70                  75                  80  


Asp Asn Glu Pro Gln Ile Ser Gly Tyr Ile Ile Asp Asp Ser Val Arg 
                85                  90                  95      


Val Glu Gln Val Ile Lys Pro Lys Lys Asn Lys Thr Glu Gly Glu Lys 
            100                 105                 110         


Ser Thr Glu Lys Pro Lys Arg Lys Lys Lys Gly Gly Lys Asn Gly Lys 
        115                 120                 125             


Gly Arg Arg Asn Lys Lys Lys Lys Asn Pro Cys Thr Ala Lys Phe Gln 
    130                 135                 140                 


Asn Phe Cys Ile His Gly Glu Cys Arg Tyr Ile Glu Asn Leu Glu Val 
145                 150                 155                 160 


Val Thr Cys Asn Cys His Gln Asp Tyr Phe Gly Glu Arg Cys Gly Glu 
                165                 170                 175     


Lys Ser Met Lys Thr His Ser Glu Asp Asp Lys Asp Leu Ser Lys Ile 
            180                 185                 190         


Ala Val Val Ala Val Thr Ile Phe Val Ser Ala Ile Ile Leu Ala Ala 
        195                 200                 205             


Ile Gly Ile Gly Ile Val Ile Thr Val His Leu Trp Lys Arg Tyr Phe 
    210                 215                 220                 


Arg Glu Tyr Glu Gly Glu Thr Glu Glu Arg Arg Arg Leu Arg Gln Glu 
225                 230                 235                 240 


Asn Gly Thr Val His Ala Ile Ala 
                245             


<210>  31
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  31
atggaccggg ccgcccggtg cagcggcgcc agctccctgc cactgctcct ggcccttgcc       60

ctgggtctag tgatccttca ctgtgtggtg gcagatggga attccaccag aagtcctgaa      120

actaatggcc tcctctgtgg agaccctgag gaaaactgtg cagctaccac cacacaatca      180

aagcggaaag gccacttctc taggtgcccc aagcaataca agcattactg catcaaaggg      240

agatgccgct tcgtggtggc cgagcagacg ccctcctgtg tctgtgatga aggctacatt      300

ggagcaaggt gtgagagagt tgacttgttt tacctaagag gagacagagg acagattctg      360

gtgatttgtt tgatagcagt tatggtagtt tttattattt tggtcatcgg tgtctgcaca      420

tgctgtcacc ctcttcggaa acgtcgtaaa agaaagaaga aagaagaaga aatggaaact      480

ctgggtaaag atataactcc tatcaatgaa gatattgaag agacaaatat tgcttaa         537


<210>  32
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210>  33
<211>  534
<212>  DNA
<213>  Mus musculus

<400>  33
atggacccaa cagccccggg tagcagtgtc agctccctgc cgctgctcct ggtccttgcc       60

ctgggtcttg caattctcca ctgtgtggta gcagatggga acacaaccag aacaccagaa      120

accaatggct ctctttgtgg agctcctggg gaaaactgca caggtaccac ccctagacag      180

aaagtgaaaa cccacttctc tcggtgcccc aagcagtaca agcattactg catccatggg      240

agatgccgct tcgtggtgga cgagcaaact ccctcctgca tctgtgagaa aggctacttt      300

ggggctcggt gtgagcgagt ggacctgttt tacctccagc aggaccgggg gcagatcctg      360

gtggtctgct tgatagtggt catggtggtg ttcatcattt tagtcatcgg cgtctgcacc      420

tgctgtcatc ctcttcggaa acatcgtaaa aaaaagaagg aagagaaaat ggagactttg      480

gataaagata aaactcccat aagtgaagat attcaagaga ccaatattgc ttaa            534


<210>  34
<211>  177
<212>  PRT
<213>  Mus musculus

<400>  34

Met Asp Pro Thr Ala Pro Gly Ser Ser Val Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Val Leu Ala Leu Gly Leu Ala Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Thr Thr Arg Thr Pro Glu Thr Asn Gly Ser Leu Cys Gly Ala 
        35                  40                  45              


Pro Gly Glu Asn Cys Thr Gly Thr Thr Pro Arg Gln Lys Val Lys Thr 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile His Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Asp Glu Gln Thr Pro Ser Cys Ile Cys Glu 
                85                  90                  95      


Lys Gly Tyr Phe Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Gln Gln Asp Arg Gly Gln Ile Leu Val Val Cys Leu Ile Val Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys His Arg Lys Lys Lys Lys Glu Glu Lys Met Glu Thr Leu 
145                 150                 155                 160 


Asp Lys Asp Lys Thr Pro Ile Ser Glu Asp Ile Gln Glu Thr Asn Ile 
                165                 170                 175     


Ala 
    


<210>  35
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  35
atgcagcgga gactggttca gcagtggagc gtcgcggtgt tcctgctgag ctacgcggtg       60

ccctcctgcg ggcgctcggt ggagggtctc agccgccgcc tcaaaagagc tgtgtctgaa      120

catcagctcc tccatgacaa ggggaagtcc atccaagatt tacggcgacg attcttcctt      180

caccatctga tcgcagaaat ccacacagct gaaatcagag ctacctcgga ggtgtcccct      240

aactccaagc cctctcccaa cacaaagaac caccccgtcc gatttgggtc tgatgatgag      300

ggcagatacc taactcagga aactaacaag gtggagacgt acaaagagca gccgctcaag      360

acacctggga agaaaaagaa aggcaagccc gggaaacgca aggagcagga aaagaaaaaa      420

cggcgaactc gctctgcctg gttagactct ggagtgactg ggagtgggct agaaggggac      480

cacctgtctg acacctccac aacgtcgctg gagctcgatt cacggaggca ttga            534


<210>  36
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gln Arg Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ala Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly 
                85                  90                  95      


Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu 
            100                 105                 110         


Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly 
        115                 120                 125             


Lys Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg 
    130                 135                 140                 


Ser Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp 
145                 150                 155                 160 


His Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Arg 
                165                 170                 175     


His 
    


<210>  37
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  37
atgcagcgga gactggttca gcagtggagc gtcgcggtgt tcctgctgag ctacgcggtg       60

ccctcctgcg ggcgctcggt ggagggtctc agccgccgcc tcaaaagagc tgtgtctgaa      120

catcagctcc tccatgacaa ggggaagtcc atccaagatt tacggcgacg attcttcctt      180

caccatctga tcgcagaaat ccacacagct gaaatcagag ctacctcgga ggtgtcccct      240

aactccaagc cctctcccaa cacaaagaac caccccgtcc gatttgggtc tgatgatgag      300

ggcagatacc taactcagga aactaacaag gtggagacgt acaaagagca gccgctcaag      360

acacctggga agaaaaagaa aggcaagccc gggaaacgca aggagcagga aaagaaaaaa      420

cggcgaactc gctctgcctg gttagactct ggagtgactg ggagtgggct agaaggggac      480

cacctgtctg acacctccac aacgtcgctg gagctcgatt cacggtaa                   528


<210>  38
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gln Arg Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ala Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly 
                85                  90                  95      


Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu 
            100                 105                 110         


Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly 
        115                 120                 125             


Lys Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg 
    130                 135                 140                 


Ser Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp 
145                 150                 155                 160 


His Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg 
                165                 170                 175 


<210>  39
<211>  528
<212>  DNA
<213>  Mus musculus

<400>  39
atgctgcgga ggctggttca gcagtggagt gtcctggtat tcctgctcag ctactccgtg       60

ccctcccgcg ggcgttcggt ggaggggctt ggccgcaggc tcaaacgcgc tgtgtctgaa      120

catcagctac tgcatgacaa gggcaagtcc atccaagact tgcgccgccg tttcttcctc      180

caccatctga tcgcggagat ccacacagcc gaaatcagag ctacctcgga ggtgtccccc      240

aactccaaac ctgctcccaa caccaaaaac caccccgtgc ggtttgggtc agacgatgag      300

ggcagatacc taactcagga aaccaacaag gtggagacgt acaaagaaca gccactcaag      360

acacccggga agaagaagaa aggcaagcct gggaaacgca gagaacagga gaaaaagaag      420

cgaaggactc ggtctgcctg gccaagcaca gctgcgagtg gcctgcttga ggaccccctg      480

ccccacacct ccaggccctc gctggagccc agcttaagga cgcattga                   528


<210>  40
<211>  175
<212>  PRT
<213>  Mus musculus

<400>  40

Met Leu Arg Arg Leu Val Gln Gln Trp Ser Val Leu Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ser Val Pro Ser Arg Gly Arg Ser Val Glu Gly Leu Gly Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ala Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly 
                85                  90                  95      


Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu 
            100                 105                 110         


Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly 
        115                 120                 125             


Lys Pro Gly Lys Arg Arg Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg 
    130                 135                 140                 


Ser Ala Trp Pro Ser Thr Ala Ala Ser Gly Leu Leu Glu Asp Pro Leu 
145                 150                 155                 160 


Pro His Thr Ser Arg Pro Ser Leu Glu Pro Ser Leu Arg Thr His 
                165                 170                 175 


<210>  41
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  41
atgatacctg caaaagacat ggctaaagtt atgattgtca tgttggcaat ttgttttctt       60

acaaaatcgg atgggaaatc tgttaagaag agatctgtga gtgaaataca gcttatgcat      120

aacctgggaa aacatctgaa ctcgatggag agagtagaat ggctgcgtaa gaagctgcag      180

gatgtgcaca attttgttgc ccttggagct cctctagctc ccagagatgc tggttcccag      240

aggccccgaa aaaaggaaga caatgtcttg gttgagagcc atgaaaaaag tcttggagag      300

gcagacaaag ctgatgtgaa tgtattaact aaagctaaat cccagtga                   348


<210>  42
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ile Pro Ala Lys Asp Met Ala Lys Val Met Ile Val Met Leu Ala 
1               5                   10                  15      


Ile Cys Phe Leu Thr Lys Ser Asp Gly Lys Ser Val Lys Lys Arg Ser 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
        35                  40                  45              


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
    50                  55                  60                  


Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser Gln 
65                  70                  75                  80  


Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu Lys 
                85                  90                  95      


Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys Ala 
            100                 105                 110         


Lys Ser Gln 
        115 


<210>  43
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  43
atgatgtctg caaacaccgt ggctaaagtg atgatcatca tgctggcagt ctgtcttctt       60

acccaaacgg atgggaaacc cgtgaggaag agagctgtca gtgaaataca gcttatgcac      120

aacctgggca aacacctggc ctccatggag aggatgcaat ggctgagaag gaagctgcaa      180

gatatgcaca attttgttag tcttggagtc caaatggctg ccagagatgg cagtcaccag      240

aagcccacca agaaggagga aaatgtcctt gttgatggca atccaaaaag tcttggtgag      300

ggagacaaag ctgatgtgga tgtattagtt aaatcaaaat ctcagtaa                   348


<210>  44
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  44

Met Met Ser Ala Asn Thr Val Ala Lys Val Met Ile Ile Met Leu Ala 
1               5                   10                  15      


Val Cys Leu Leu Thr Gln Thr Asp Gly Lys Pro Val Arg Lys Arg Ala 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Ala Ser 
        35                  40                  45              


Met Glu Arg Met Gln Trp Leu Arg Arg Lys Leu Gln Asp Met His Asn 
    50                  55                  60                  


Phe Val Ser Leu Gly Val Gln Met Ala Ala Arg Asp Gly Ser His Gln 
65                  70                  75                  80  


Lys Pro Thr Lys Lys Glu Glu Asn Val Leu Val Asp Gly Asn Pro Lys 
                85                  90                  95      


Ser Leu Gly Glu Gly Asp Lys Ala Asp Val Asp Val Leu Val Lys Ser 
            100                 105                 110         


Lys Ser Gln 
        115 


<210>  45
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: PTHrP (37-70)-Fc 
       sequence"

<400>  45
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgct       60

gtgtctgagc accagctgct gcacgacaag ggcaagtcca tccaggacct gcggcggaga      120

ttcttcctgc accacctgat cgccgagatc cacaccgctg gcggtggaga caaaactcac      180

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      240

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      300

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      360

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      420

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      480

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      540

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc      600

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      660

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc      720

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      780

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      840

ccgggtaaat ga                                                          852


<210>  46
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: PTHrP (37-70)-Fc 
       sequence"

<400>  46

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys 
            20                  25                  30          


Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala 
        35                  40                  45              


Glu Ile His Thr Ala Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
    50                  55                  60                  


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
65                  70                  75                  80  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                85                  90                  95      


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            100                 105                 110         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        115                 120                 125             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    130                 135                 140                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
145                 150                 155                 160 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                165                 170                 175     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            180                 185                 190         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        195                 200                 205             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    210                 215                 220                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
225                 230                 235                 240 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                245                 250                 255     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            260                 265                 270         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280             


<210>  47
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: PTHrP (37-122)-Fc 
       sequence"

<400>  47
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccgct       60

gtgtctgagc accagctgct gcacgacaag ggcaagtcca tccaggacct gcggcggaga      120

ttcttcctgc accacctgat cgccgagatc cacaccgctg agatccgggc cacatctgag      180

gtgtccccca actccaagcc cagccccaac accaagaacc accctgtcag attcggctcc      240

gacgacgagg gcagatacct gacccaggaa acaaacaagg tggaaaccta caaagagcag      300

cccctgaaaa cccccggcgg tggagacaaa actcacacat gcccaccgtg cccagcacct      360

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      420

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      480

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      540

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      600

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      660

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      720

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      780

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      840

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      900

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      960

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1008


<210>  48
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: PTHrP (37-122)-Fc 
       sequence"

<400>  48

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys 
            20                  25                  30          


Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala 
        35                  40                  45              


Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn 
    50                  55                  60                  


Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser 
65                  70                  75                  80  


Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr 
                85                  90                  95      


Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Gly Gly Asp Lys Thr His 
            100                 105                 110         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        115                 120                 125             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    130                 135                 140                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
145                 150                 155                 160 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                165                 170                 175     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            180                 185                 190         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        195                 200                 205             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    210                 215                 220                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
225                 230                 235                 240 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                245                 250                 255     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            260                 265                 270         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        275                 280                 285             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330                 335 


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: (Gly)3Lys(Gly)4 
       linker"

<400>  49

Gly Gly Gly Lys Gly Gly Gly Gly 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: (Gly)3AsnGlySer(Gly)2 
       Linker"

<400>  50

Gly Gly Gly Asn Gly Ser Gly Gly 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: (Gly)3Cys(Gly)4 
       linker"

<400>  51

Gly Gly Gly Cys Gly Gly Gly Gly 
1               5               


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: GlyProAsnGlyGly 
       linker"

<400>  52

Gly Pro Asn Gly Gly 
1               5   


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  53
ggagatggca caggaggaa                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  54
gcccgtagtg cttcagctt                                                    19


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  55
aagctgtgcg atgtccatgt                                                   20


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  56
aagccacaaa ccctttgaaa a                                                 21


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  57
gtccgcaaat gaccccttt                                                    19


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  58
cccacccact ctctgacttt c                                                 21


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  59
agacaaatgt gcttcgaaaa agaa                                              24


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  60
gaagagataa agttgttggt ttggc                                             25


<210>  61
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  61
agtgaaaact tcgatgatta catgaa                                            26


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  62
gcctgccact ttccttgtg                                                    19


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  63
caagaatacc aaagtgcgat caa                                               23


<210>  64
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  64
gagctgggtc ttttcagaat aataag                                            26


<210>  65
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  65
gagggctccg gcacttc                                                      17


<210>  66
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  66
cgtacttgct tttcccagat ga                                                22


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  67
gcacggtgaa gccattcata tg                                                22


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  68
tcggcgtgca tccgcttgtg                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  69
ggttcaaggc cgtgttaagg                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  70
cgtcatctgt gcagcatagg                                                   20


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  71
cgccccccag aaggttat                                                     18


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  72
cgatgcggtg gttccat                                                      17


<210>  73
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  73
ttggctccct tcagtttgg                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  74
ctacccagcc acgttgcat                                                    19


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  75
ggcttccact tcaacgctat g                                                 21


<210>  76
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  76
atgctccgcc tgaagaaac                                                    19


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  77
gcccaactgt gacttccatt aa                                                22


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  78
gtagcactcc cctcgagtga t                                                 21


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  79
gatctggtgg aacgaggcaa                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  80
cttcgggttc tggaggcttg                                                   20


<210>  81
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  81
cagcacattt atcccggtgt ac                                                22


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  82
aaatgccgcc atccacatag                                                   20


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  83
gctggaggag tgtttttttg c                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  84
agttgaacca agcaggtcac a                                                 21


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  85
tctgcaatgg tgaggtgcag                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  86
gctactccca cttcgtgctt                                                   20


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  87
tacttcaaca agcccacagg c                                                 21


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  88
atagagcggg ctgcttttgt                                                   20


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  89
agaagatggg ctgaatccct tt                                                22


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  90
atcgcagtca agcccaaagt                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  91
tcagagaggc agattcgcaa                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  92
gggtgacccc atactgctct                                                   20


<210>  93
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  93
tcctgatgga aacgctatgg ag                                                22


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  94
attcgcagcc tggaagatgt                                                   20


