                         SEQUENCE LISTING

<110>  PhaseRx, Inc.
 
<120>  BLOCK COPOLYMERS

<130>  3800.PCT1

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  1
acgacaaaug ugugcgauct t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  2
gcgcguugac uuauucaugt t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  3
gcgccgugau gaauaucgat t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  4
ucgccgaaau acgguccuat t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  5
gccgaaauac gguccuaugt t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  6
guaagugccc gaaguguaat t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  7
gugcaguauc cucugacagt t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  8
cugguguccc ggauaucagt t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  9
ucuaguuguc gacaccuact t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  10
auggcucuag uugucgacat t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  11
auuucgccga aauacgguct t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  12
ggcucuaguu gucgacacct t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  13
aacugguguc ccggauauct t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  14
gucaauucag cgaaguccut t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  15
cucuaguugu cgacaccuat t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  16
gcgaucggag gaaugccugt t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  17
aaauacgguc cuauggcugt t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  18
uuuacuucuu gacgguccat t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  19
ucauggguca auucagcgat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  20
ugugcgaucg gaggaaugct t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  21
gcgcgccgug augaauauct t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  22
uuucgccgaa auacggucct t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  23
ugguuucucg aucaggacct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  24
uuaugcacgg uccccaaugt t                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  25
cgaaauacgg uccuauggct t                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  26
uggugccacg acaaaugugt t                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  27
gaucgcacac auuugucgut t                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  28
caugaauaag ucaacgcgct t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  29
ucgauauuca ucacggcgct t                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  30
uaggaccgua uuucggcgat t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  31
cauaggaccg uauuucggct t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  32
uuacacuucg ggcacuuact t                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  33
cugucagagg auacugcact t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  34
cugauauccg ggacaccagt t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  35
guaggugucg acaacuagat t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  36
ugucgacaac uagagccaut t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  37
gaccguauuu cggcgaaaut t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  38
ggugucgaca acuagagcct t                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  39
gauauccggg acaccaguut t                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  40
aggacuucgc ugaauugact t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  41
uaggugucga caacuagagt t                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  42
caggcauucc uccgaucgct t                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  43
cagccauagg accguauuut t                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  44
uggaccguca agaaguaaat t                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  45
ucgcugaauu gacccaugat t                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  46
gcauuccucc gaucgcacat t                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  47
gauauucauc acggcgcgct t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  48
ggaccguauu ucggcgaaat t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  49
gguccugauc gagaaaccat t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  50
cauuggggac cgugcauaat t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  51
gccauaggac cguauuucgt t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  52
cacauuuguc guggcaccat t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  53
cagggguccu cugugaacut t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  54
ugcucuucgu caucugacct t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  55
gcucuucguc aucugaccat t                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  56
ggagcuaaaa uggcagugct t                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  57
ccugugcagc uggaauucut t                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  58
agaguagcug caggggucct t                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  59
cugacuaucc aguugauggt t                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  60
ccauuccauu guuugugcat t                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  61
auaccauucc auuguuugut t                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  62
gcaggggucc ucugugaact t                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  63
ccaggaccuc auggaugggt t                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  64
uaccauucca uuguuugugt t                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  65
ugugaacuug cucaggacat t                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  66
uggauaucgc caggaugaut t                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  67
ugacuaucca guugaugggt t                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  68
accaugcaga auacaaaugt t                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  69
acuguuggau ugauucgaat t                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  70
cuauccaguu gaugggcugt t                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  71
gacuauccag uugaugggct t                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  72
gcugacuauc caguugaugt t                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  73
aauaccauuc cauuguuugt t                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  74
acccuggugc ugacuaucct t                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  75
ugcuuuauuc ucccauugat t                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: sense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  76
aggagcuaaa auggcagugt t                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  77
aguucacaga ggaccccugt t                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  78
ggucagauga cgaagagcat t                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  79
uggucagaug acgaagagct t                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  80
gcacugccau uuuagcucct t                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  81
agaauuccag cugcacaggt t                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  82
ggaccccugc agcuacucut t                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  83
ccaucaacug gauagucagt t                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  84
ugcacaaaca auggaauggt t                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  85
acaaacaaug gaaugguaut t                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  86
guucacagag gaccccugct t                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  87
cccauccaug agguccuggt t                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  88
cacaaacaau ggaaugguat t                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  89
uguccugagc aaguucacat t                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  90
aucauccugg cgauauccat t                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  91
cccaucaacu ggauagucat t                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  92
cauuuguauu cugcauggut t                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  93
uucgaaucaa uccaacagut t                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  94
cagcccauca acuggauagt t                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  95
gcccaucaac uggauaguct t                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  96
caucaacugg auagucagct t                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  97
caaacaaugg aaugguauut t                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  98
ggauagucag caccagggut t                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  99
ucaaugggag aauaaagcat t                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of the artificial sequence: antisense strand of dsRNA


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  /mod_base = "nucleoside: lacks 5'-phosphate group"

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  (3)..(5)
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  /mod_base = "5'-phosphorothioate thymidine"

<400>  100
cacugccauu uuagcuccut t                                                 21


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Cys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Cys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Cys 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10      


<210>  107
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
        35                  40                  45              


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
    50                  55                  60                  


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
65                  70                  75                  80  


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
                85                  90                  95      


Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
            100                 105                 110         


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
        115                 120                 125             


Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys 
    130                 135                 140                 


Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile 
145                 150                 155                 160 


Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr 
                165                 170                 175     


Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser 
            180                 185                 190         


Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala 
        195                 200                 205             


Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu 
    210                 215                 220                 


Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly 
                245                 250                 255     


Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu 
            260                 265                 270         


Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met 
        275                 280                 285             


Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu 
    290                 295                 300                 


Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg 
305                 310                 315                 320 


Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala 
                325                 330                 335     


Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro 
            340                 345                 350         


Lys Phe 
        


<210>  108
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ornithine transcarbamylase with mouse mitochondrial leader 
       sequence

<400>  108

Met Leu Ser Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Leu Arg Lys 
1               5                   10                  15      


Gly His Thr Ser Val Val Arg His Phe Trp Cys Gly Lys Pro Val Gln 
            20                  25                  30          


Ser Gln Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
        35                  40                  45              


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
    50                  55                  60                  


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
65                  70                  75                  80  


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
                85                  90                  95      


Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
            100                 105                 110         


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
        115                 120                 125             


Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys 
    130                 135                 140                 


Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile 
145                 150                 155                 160 


Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr 
                165                 170                 175     


Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser 
            180                 185                 190         


Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala 
        195                 200                 205             


Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu 
    210                 215                 220                 


Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly 
                245                 250                 255     


Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu 
            260                 265                 270         


Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met 
        275                 280                 285             


Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu 
    290                 295                 300                 


Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg 
305                 310                 315                 320 


Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala 
                325                 330                 335     


Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro 
            340                 345                 350         


Lys Phe 
        


<210>  109
<211>  1262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding human ornithine transcarbamylase, codon-optimized 
       for mouse expression


<220>
<221>  promoter
<222>  (1)..(20)
<223>  T7 promoter

<400>  109
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatgctg ttcaacctca gaatcctcct caataacgcc gcctttagaa acggtcataa      120

cttcatggtc agaaacttta gatgtggtca gcctctccag aacaaagtgc agctcaaggg      180

gcgggacctg ctcaccctga aaaatttcac aggcgaggaa atcaagtaca tgctctggct      240

gtctgccgat ctgaagttca ggatcaagca gaagggcgaa tatctcccac tgctccaggg      300

gaaaagtctg ggtatgatct tcgaaaagcg gagtactagg accagactgt caacagagac      360

tggattcgct ctgctcggag gacacccatg ctttctgacc acacaggaca ttcatctcgg      420

tgtgaacgag tcactgaccg acacagctcg agtcctcagc tccatggcag atgccgtgct      480

ggcaagggtc tacaaacaga gtgacctcga taccctggct aaggaagcaa gcatccccat      540

cattaatgga ctctccgacc tgtatcaccc tatccagatt ctggccgatt acctcaccct      600

gcaggagcat tattctagtc tgaaagggct cacactgagc tggattggcg acggaaacaa      660

tatcctgcac tccattatga tgtctgccgc taagtttggc atgcatctgc aggcagccac      720

accaaaagga tacgaacccg atgcttccgt gactaagctg gccgaacagt atgctaaaga      780

gaacggaact aagctgctcc tgaccaatga ccccctggag gctgcacacg ggggtaacgt      840

cctgatcact gatacctgga tttccatggg ccaggaggaa gagaagaaaa agcgcctgca      900

ggcattccag ggataccagg tgacaatgaa aactgccaag gtcgccgctt ctgattggac      960

ttttctccat tgtctgcccc gaaagcctga agaggtggac gatgaggtct tctattcacc     1020

tcggagcctg gtgtttccag aagccgagaa tcgcaagtgg acaatcatgg cagtgatggt     1080

gtccctcctc acagactatt ccccacagct ccagaagccc aagttttgag cggccgctta     1140

attaagctgc cttctgcggg gcttgccttc tggccatgcc cttcttctct cccttgcacc     1200

tgtacctctt ggtctttgaa taaagcctga gtaggaagtc tagagtttaa acatttaaat     1260

ct                                                                    1262


<210>  110
<211>  1262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding human ornithine transcarbamylase with mouse 
       mitochondrial leader sequence, codon-optimized for mouse 
       expression


<220>
<221>  promoter
<222>  (1)..(20)
<223>  T7 promoter

<400>  110
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatgctc tctaacctca ggattctgct caacaacgct gctctgcgga aaggccatac      120

ctctgtcgtc aggcacttct ggtgtgggaa acccgtgcag agccaggtgc agctcaaggg      180

gcgggacctg ctcaccctga aaaatttcac aggcgaggaa atcaagtaca tgctctggct      240

gtctgccgat ctgaagttca ggatcaagca gaagggcgaa tatctcccac tgctccaggg      300

gaaaagtctg ggtatgatct tcgaaaagcg gagtactagg accagactgt caacagagac      360

tggattcgct ctgctcggag gacacccatg ctttctgacc acacaggaca ttcatctcgg      420

tgtgaacgag tcactgaccg acacagctcg agtcctcagc tccatggcag atgccgtgct      480

ggcaagggtc tacaaacaga gtgacctcga taccctggct aaggaagcaa gcatccccat      540

cattaatgga ctctccgacc tgtatcaccc tatccagatt ctggccgatt acctcaccct      600

gcaggagcat tattctagtc tgaaagggct cacactgagc tggattggcg acggaaacaa      660

tatcctgcac tccattatga tgtctgccgc taagtttggc atgcatctgc aggcagccac      720

accaaaagga tacgaacccg atgcttccgt gactaagctg gccgaacagt atgctaaaga      780

gaacggaact aagctgctcc tgaccaatga ccccctggag gctgcacacg ggggtaacgt      840

cctgatcact gatacctgga tttccatggg ccaggaggaa gagaagaaaa agcgcctgca      900

ggcattccag ggataccagg tgacaatgaa aactgccaag gtcgccgctt ctgattggac      960

ttttctccat tgtctgcccc gaaagcctga agaggtggac gatgaggtct tctattcacc     1020

tcggagcctg gtgtttccag aagccgagaa tcgcaagtgg acaatcatgg cagtgatggt     1080

gtccctcctc acagactatt ccccacagct ccagaagccc aagttttgag cggccgctta     1140

attaagctgc cttctgcggg gcttgccttc tggccatgcc cttcttctct cccttgcacc     1200

tgtacctctt ggtctttgaa taaagcctga gtaggaagtc tagagtttaa acatttaaat     1260

ct                                                                    1262


<210>  111
<211>  1262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding human ornithine transcarbamylase, codon-optimized 
       for human expression


<220>
<221>  promoter
<222>  (1)..(20)
<223>  T7 promoter

<400>  111
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatgctg tttaacctga ggattctgct gaacaacgct gcttttcgga acggccacaa      120

ctttatggtg cggaactttc ggtgcggaca gccactgcag aacaaagtgc agctgaaggg      180

gagggacctg ctgaccctga aaaatttcac aggagaggaa atcaagtaca tgctgtggct      240

gtctgccgat ctgaagttcc ggatcaagca gaagggcgaa tatctgccac tgctgcaggg      300

caaaagtctg gggatgatct tcgaaaagag gagtactcgg accagactgt caacagagac      360

tggattcgct ctgctgggag gacacccatg ctttctgacc acacaggaca ttcatctggg      420

cgtgaacgag tcactgaccg acacagctcg agtcctgagc tccatggcag atgccgtgct      480

ggcacgggtc tacaaacaga gcgacctgga taccctggct aaggaagcaa gcatccccat      540

cattaatggg ctgtccgacc tgtatcaccc tatccagatt ctggccgatt acctgaccct      600

gcaggagcat tattctagtc tgaaaggcct gacactgagc tggattgggg acggaaacaa      660

tatcctgcac tccattatga tgtctgccgc taagtttgga atgcatctgc aggcagccac      720

accaaaaggc tacgaacccg atgccagtgt gactaagctg gccgaacagt atgctaaaga      780

gaacggcact aagctgctgc tgaccaatga ccctctggag gctgcacacg gaggcaacgt      840

cctgatcact gatacctgga tttccatggg ccaggaggaa gagaagaaaa agcgcctgca      900

ggcattccag gggtaccagg tgacaatgaa aactgccaag gtcgccgctt ctgattggac      960

ttttctgcat tgtctgcccc gaaaacctga agaggtggac gatgaggtct tctattcacc     1020

taggagcctg gtgtttccag aagccgagaa tcgcaagtgg acaatcatgg ctgtgatggt     1080

gtccctgctg actgattatt ccccccagct gcagaaacct aagttctgag cggccgctta     1140

attaagctgc cttctgcggg gcttgccttc tggccatgcc cttcttctct cccttgcacc     1200

tgtacctctt ggtctttgaa taaagcctga gtaggaagtc tagagtttaa acatttaaat     1260

ct                                                                    1262


<210>  112
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human ornithine transcarbamylase, codon-optimized 
       for mouse expression

<400>  112
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug cuguucaacc       60

ucagaauccu ccucaauaac gccgccuuua gaaacgguca uaacuucaug gucagaaacu      120

uuagaugugg ucagccucuc cagaacaaag ugcagcucaa ggggcgggac cugcucaccc      180

ugaaaaauuu cacaggcgag gaaaucaagu acaugcucug gcugucugcc gaucugaagu      240

ucaggaucaa gcagaagggc gaauaucucc cacugcucca ggggaaaagu cuggguauga      300

ucuucgaaaa gcggaguacu aggaccagac ugucaacaga gacuggauuc gcucugcucg      360

gaggacaccc augcuuucug accacacagg acauucaucu cggugugaac gagucacuga      420

ccgacacagc ucgaguccuc agcuccaugg cagaugccgu gcuggcaagg gucuacaaac      480

agagugaccu cgauacccug gcuaaggaag caagcauccc caucauuaau ggacucuccg      540

accuguauca cccuauccag auucuggccg auuaccucac ccugcaggag cauuauucua      600

gucugaaagg gcucacacug agcuggauug gcgacggaaa caauauccug cacuccauua      660

ugaugucugc cgcuaaguuu ggcaugcauc ugcaggcagc cacaccaaaa ggauacgaac      720

ccgaugcuuc cgugacuaag cuggccgaac aguaugcuaa agagaacgga acuaagcugc      780

uccugaccaa ugacccccug gaggcugcac acggggguaa cguccugauc acugauaccu      840

ggauuuccau gggccaggag gaagagaaga aaaagcgccu gcaggcauuc cagggauacc      900

aggugacaau gaaaacugcc aaggucgccg cuucugauug gacuuuucuc cauugucugc      960

cccgaaagcc ugaagaggug gacgaugagg ucuucuauuc accucggagc cugguguuuc     1020

cagaagccga gaaucgcaag uggacaauca uggcagugau ggugucccuc cucacagacu     1080

auuccccaca gcuccagaag cccaaguuuu gagcggccgc uuaauuaagc ugccuucugc     1140

ggggcuugcc uucuggccau gcccuucuuc ucucccuugc accuguaccu cuuggucuuu     1200

gaauaaagcc ugaguaggaa g                                               1221


<210>  113
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human ornithine transcarbamylase with mouse 
       mitochondrial leader sequence, codon-optimized for mouse 
       expression

<400>  113
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug cucucuaacc       60

ucaggauucu gcucaacaac gcugcucugc ggaaaggcca uaccucuguc gucaggcacu      120

ucuggugugg gaaacccgug cagagccagg ugcagcucaa ggggcgggac cugcucaccc      180

ugaaaaauuu cacaggcgag gaaaucaagu acaugcucug gcugucugcc gaucugaagu      240

ucaggaucaa gcagaagggc gaauaucucc cacugcucca ggggaaaagu cuggguauga      300

ucuucgaaaa gcggaguacu aggaccagac ugucaacaga gacuggauuc gcucugcucg      360

gaggacaccc augcuuucug accacacagg acauucaucu cggugugaac gagucacuga      420

ccgacacagc ucgaguccuc agcuccaugg cagaugccgu gcuggcaagg gucuacaaac      480

agagugaccu cgauacccug gcuaaggaag caagcauccc caucauuaau ggacucuccg      540

accuguauca cccuauccag auucuggccg auuaccucac ccugcaggag cauuauucua      600

gucugaaagg gcucacacug agcuggauug gcgacggaaa caauauccug cacuccauua      660

ugaugucugc cgcuaaguuu ggcaugcauc ugcaggcagc cacaccaaaa ggauacgaac      720

ccgaugcuuc cgugacuaag cuggccgaac aguaugcuaa agagaacgga acuaagcugc      780

uccugaccaa ugacccccug gaggcugcac acggggguaa cguccugauc acugauaccu      840

ggauuuccau gggccaggag gaagagaaga aaaagcgccu gcaggcauuc cagggauacc      900

aggugacaau gaaaacugcc aaggucgccg cuucugauug gacuuuucuc cauugucugc      960

cccgaaagcc ugaagaggug gacgaugagg ucuucuauuc accucggagc cugguguuuc     1020

cagaagccga gaaucgcaag uggacaauca uggcagugau ggugucccuc cucacagacu     1080

auuccccaca gcuccagaag cccaaguuuu gagcggccgc uuaauuaagc ugccuucugc     1140

ggggcuugcc uucuggccau gcccuucuuc ucucccuugc accuguaccu cuuggucuuu     1200

gaauaaagcc ugaguaggaa g                                               1221


<210>  114
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human ornithine transcarbamylase, codon-optimized 
       for human expression

<400>  114
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug cuguuuaacc       60

ugaggauucu gcugaacaac gcugcuuuuc ggaacggcca caacuuuaug gugcggaacu      120

uucggugcgg acagccacug cagaacaaag ugcagcugaa ggggagggac cugcugaccc      180

ugaaaaauuu cacaggagag gaaaucaagu acaugcugug gcugucugcc gaucugaagu      240

uccggaucaa gcagaagggc gaauaucugc cacugcugca gggcaaaagu cuggggauga      300

ucuucgaaaa gaggaguacu cggaccagac ugucaacaga gacuggauuc gcucugcugg      360

gaggacaccc augcuuucug accacacagg acauucaucu gggcgugaac gagucacuga      420

ccgacacagc ucgaguccug agcuccaugg cagaugccgu gcuggcacgg gucuacaaac      480

agagcgaccu ggauacccug gcuaaggaag caagcauccc caucauuaau gggcuguccg      540

accuguauca cccuauccag auucuggccg auuaccugac ccugcaggag cauuauucua      600

gucugaaagg ccugacacug agcuggauug gggacggaaa caauauccug cacuccauua      660

ugaugucugc cgcuaaguuu ggaaugcauc ugcaggcagc cacaccaaaa ggcuacgaac      720

ccgaugccag ugugacuaag cuggccgaac aguaugcuaa agagaacggc acuaagcugc      780

ugcugaccaa ugacccucug gaggcugcac acggaggcaa cguccugauc acugauaccu      840

ggauuuccau gggccaggag gaagagaaga aaaagcgccu gcaggcauuc cagggguacc      900

aggugacaau gaaaacugcc aaggucgccg cuucugauug gacuuuucug cauugucugc      960

cccgaaaacc ugaagaggug gacgaugagg ucuucuauuc accuaggagc cugguguuuc     1020

cagaagccga gaaucgcaag uggacaauca uggcugugau ggugucccug cugacugauu     1080

auucccccca gcugcagaaa ccuaaguucu gagcggccgc uuaauuaagc ugccuucugc     1140

ggggcuugcc uucuggccau gcccuucuuc ucucccuugc accuguaccu cuuggucuuu     1200

gaauaaagcc ugaguaggaa g                                               1221


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  115

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Cys 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  116

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10      


<210>  117
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  118
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human methylmalonyl-coenzyme A mutase

<400>  118
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug uuaagagcua       60

agaaucagcu uuuuuuacuu ucaccucauu accugaggca gguaaaagaa ucaucaggcu      120

ccaggcucau acagcaacga cuucuacacc agcaacagcc ccuucaccca gaaugggcug      180

cccuggcuaa aaagcagcug aaaggcaaaa acccagaaga ccuaauaugg cacaccccgg      240

aagggaucuc uauaaaaccc uuguauucca agagagauac uauggacuua ccugaagaac      300

uuccaggagu gaagccauuc acacguggac cauauccuac cauguauacc uuuaggcccu      360

ggaccauccg ccaguaugcu gguuuuagua cuguggaaga aagcaauaag uucuauaagg      420

acaacauuaa ggcuggucag cagggauuau caguugccuu ugaucuggcg acacaucgug      480

gcuaugauuc agacaacccu cgaguucgug gugauguugg aauggcugga guugcuauug      540

acacugugga agauaccaaa auucuuuuug auggaauucc uuuagaaaaa augucaguuu      600

ccaugacuau gaauggagca guuauuccag uucuugcaaa uuuuauagua acuggagaag      660

aacaaggugu accuaaagag aagcuuacug guaccaucca aaaugauaua cuaaaggaau      720

uuaugguucg aaauacauac auuuuuccuc cagaaccauc caugaaaauu auugcugaca      780

uauuugaaua uacagcaaag cacaugccaa aauuuaauuc aauuucaauu aguggauacc      840

auaugcagga agcaggggcu gaugccauuc uggagcuggc cuauacuuua gcagauggau      900

uggaguacuc uagaacugga cuccaggcug gccugacaau ugaugaauuu gcaccaaggu      960

ugucuuucuu cuggggaauu ggaaugaauu ucuauaugga aauagcaaag augagagcug     1020

guagaagacu cugggcucac uuaauagaga aaauguuuca gccuaaaaac ucaaaaucuc     1080

uucuucuaag agcacacugu cagacaucug gauggucacu uacugagcag gaucccuaca     1140

auaauauugu ccguacugca auagaagcaa uggcagcagu auuuggaggg acucagucuu     1200

ugcacacaaa uucuuuugau gaagcuuugg guuugccaac ugugaaaagu gcucgaauug     1260

ccaggaacac acaaaucauc auucaagaag aaucugggau ucccaaagug gcugauccuu     1320

ggggagguuc uuacaugaug gaaugucuca caaaugaugu uuaugaugcu gcuuuaaagc     1380

ucauuaauga aauugaagaa auggguggaa uggccaaagc uguagcugag ggaauaccua     1440

aacuucgaau ugaagaaugu gcugcccgaa gacaagcuag aauagauucu gguucugaag     1500

uaauuguugg aguaaauaag uaccaguugg aaaaagaaga cgcuguagaa guucuggcaa     1560

uugauaauac uucagugcga aacaggcaga uugaaaaacu uaagaagauc aaauccagca     1620

gggaucaagc uuuggcugaa cguugucuug cugcacuaac cgaaugugcu gcuagcggag     1680

auggaaauau ccuggcucuu gcaguggaug caucucgggc aagauguaca gugggagaaa     1740

ucacagaugc ccugaaaaag guauuuggug aacauaaagc gaaugaucga auggugagug     1800

gagcauaucg ccaggaauuu ggagaaagua aagagauaac aucugcuauc aagaggguuc     1860

auaaauucau ggaacgugaa ggucgcagac cucgucuucu uguagcaaaa augggacaag     1920

auggccauga cagaggagca aaaguuauug cuacaggauu ugcugaucuu gguuuugaug     1980

uggacauagg cccucuuuuc cagacuccuc gugaaguggc ccagcaggcu guggaugcgg     2040

augugcaugc ugugggcaua agcacccucg cugcugguca uaaaacccua guuccugaac     2100

ucaucaaaga acuuaacucc cuuggacggc cagauauucu ugucaugugu ggagggguga     2160

uaccaccuca ggauuaugaa uuucuguuug aaguuggugu uuccaaugua uuugguccug     2220

ggacucgaau uccaaaggcu gccguucagg ugcuugauga uauugagaag uguuuggaaa     2280

agaagcagca aucuguauaa gcggccgcuu aauuaagcug ccuucugcgg ggcuugccuu     2340

cuggccaugc ccuucuucuc ucccuugcac cuguaccucu uggucuuuga auaaagccug     2400

aguaggaag                                                             2409


<210>  119
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp 
    50                  55                  60                  


Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg 
65                  70                  75                  80  


Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val 
                85                  90                  95      


Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val 
            100                 105                 110         


Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met 
        115                 120                 125             


Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly 
    130                 135                 140                 


Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp 
145                 150                 155                 160 


Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp 
                165                 170                 175     


Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile 
            180                 185                 190         


Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile 
        195                 200                 205             


Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly 
    210                 215                 220                 


Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp 
225                 230                 235                 240 


Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp 
                245                 250                 255     


Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile 
            260                 265                 270         


Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg 
        275                 280                 285             


Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro 
    290                 295                 300                 


Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala 
305                 310                 315                 320 


Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu 
                325                 330                 335     


Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr 
            340                 345                 350         


Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp 
        355                 360                 365             


Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His 
    370                 375                 380                 


Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val 
385                 390                 395                 400 


Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg 
                405                 410                 415     


Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp 
            420                 425                 430         


Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met 
        435                 440                 445             


Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys 
    450                 455                 460                 


Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His 
465                 470                 475                 480 


Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys 
                485                 490                 495     


Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe 
            500                 505                 510         


Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile 
        515                 520                 525             


Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln 
    530                 535                 540                 


Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu 
545                 550                 555                 560 


Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn 
                565                 570                 575     


Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val 
            580                 585                 590         


Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp 
        595                 600                 605             


Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn 
    610                 615                 620                 


Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr 
625                 630                 635                 640 


Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu 
                645                 650                 655     


Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala 
            660                 665                 670         


Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys 
        675                 680                 685             


Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr 
    690                 695                 700                 


Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu 
705                 710                 715                 720 


Gly Asp Leu Leu Val Glu Leu Glu 
                725             


<210>  120
<211>  2343
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human propionyl CoA carboxylase, alpha polypeptide 
       (PCCA)

<400>  120
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gcgggguucu       60

gggucgggac agcaccgcug gucgcugccg gacggcgugg gcgguggccg ccgcagcagc      120

ugaugcugag cgcggcgcug cggacccuga agcauguucu guacuauuca agacagugcu      180

uaaugguguc ccguaaucuu gguucagugg gauaugaucc uaaugaaaaa acuuuugaua      240

aaauucuugu ugcuaauaga ggagaaauug caugucgggu uauuagaacu ugcaagaaga      300

ugggcauuaa gacaguugcc auccacagug auguugaugc uaguucuguu caugugaaaa      360

uggcggauga ggcugucugu guuggcccag cucccaccag uaaaagcuac cucaacaugg      420

augccaucau ggaagccauu aagaaaacca gggcccaagc uguacaucca gguuauggau      480

uccuuucaga aaacaaagaa uuugccagau guuuggcagc agaagauguc guuuucauug      540

gaccugacac acaugcuauu caagccaugg gcgacaagau ugaaagcaaa uuauuagcua      600

agaaagcaga gguuaauaca aucccuggcu uugauggagu agucaaggau gcagaagaag      660

cugucagaau ugcaagggaa auuggcuacc cugucaugau caaggccuca gcagguggug      720

gugggaaagg caugcgcauu gcuugggaug augaagagac cagggauggu uuuagauugu      780

caucucaaga agcugcuucu aguuuuggcg augauagacu acuaauagaa aaauuuauug      840

auaauccucg ucauauagaa auccagguuc uaggugauaa acaugggaau gcuuuauggc      900

uuaaugaaag agagugcuca auucagagaa gaaaucagaa ggugguggag gaagcaccaa      960

gcauuuuuuu ggaugcggag acucgaagag cgaugggaga acaagcugua gcucuugcca     1020

gagcaguaaa auauuccucu gcugggaccg uggaguuccu uguggacucu aagaagaauu     1080

uuuauuucuu ggaaaugaau acaagacucc agguugagca uccugucaca gaaugcauua     1140

cuggccugga ccuaguccag gaaaugaucc guguugcuaa gggcuacccu cucaggcaca     1200

aacaagcuga uauucgcauc aacggcuggg caguugaaug ucggguuuau gcugaggacc     1260

ccuacaaguc uuuugguuua ccaucuauug ggagauuguc ucaguaccaa gaaccguuac     1320

aucuaccugg uguccgagug gacaguggca uccaaccagg aagugauauu agcauuuauu     1380

augauccuau gauuucaaaa cuaaucacau auggcucuga uagaacugag gcacugaaga     1440

gaauggcaga ugcacuggau aacuauguua uucgaggugu uacacauaau auugcauuac     1500

uucgagaggu gauaaucaac ucacgcuuug uaaaaggaga caucagcacu aaauuucucu     1560

ccgaugugua uccugauggc uucaaaggac acaugcuaac caagagugag aagaaccagu     1620

uauuggcaau agcaucauca uuguuugugg cauuccaguu aagagcacaa cauuuucaag     1680

aaaauucaag aaugccuguu auuaaaccag acauagccaa cugggagcuc ucaguaaaau     1740

ugcaugauaa aguucauacc guaguagcau caaacaaugg gucaguguuc ucgguggaag     1800

uugauggguc gaaacuaaau gugaccagca cguggaaccu ggcuucgccc uuauugucug     1860

ucagcguuga uggcacucag aggacugucc agugucuuuc ucgagaagca gguggaaaca     1920

ugagcauuca guuucuuggu acaguguaca aggugaauau cuuaaccaga cuugccgcag     1980

aauugaacaa auuuaugcug gaaaaaguga cugaggacac aagcaguguu cugcguuccc     2040

cgaugcccgg agugguggug gccgucucug ucaagccugg agacgcggua gcagaagguc     2100

aagaaauuug ugugauugaa gccaugaaaa ugcagaauag uaugacagcu gggaaaacug     2160

gcacggugaa aucugugcac ugucaagcug gagacacagu uggagaaggg gaucugcucg     2220

uggagcugga augagcggcc gcuuaauuaa gcugccuucu gcggggcuug ccuucuggcc     2280

augcccuucu ucucucccuu gcaccuguac cucuuggucu uugaauaaag ccugaguagg     2340

aag                                                                   2343


<210>  121
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln 
        515                 520                 525             


Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
    530                 535                 


<210>  122
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA encoding human propionyl CoA carboxylase, beta polypeptide 
       (PCCB)

<400>  122
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gcggcggcau       60

uacggguggc ggcggucggg gcaaggcuca gcguucuggc gagcggucuc cgcgccgcgg      120

uccgcagccu uugcagccag gccaccucug uuaacgaacg caucgaaaac aagcgccgga      180

ccgcgcugcu gggagggggc caacgccgua uugacgcgca gcacaagcga ggaaagcuaa      240

cagccaggga gaggaucagu cucuugcugg acccuggcag cuuuguugag agcgacaugu      300

uuguggaaca cagaugugca gauuuuggaa uggcugcuga uaagaauaag uuuccuggag      360

acagcguggu cacuggacga ggccgaauca auggaagauu gguuuauguc uucagucagg      420

auuuuacagu uuuuggaggc agucugucag gagcacaugc ccaaaagauc ugcaaaauca      480

uggaccaggc cauaacggug ggggcuccag ugauugggcu gaaugacucu gggggagcac      540

ggauccaaga aggaguggag ucuuuggcug gcuaugcaga caucuuucug aggaauguua      600

cggcauccgg agucaucccu cagauuucuc ugaucauggg cccaugugcu gguggggccg      660

ucuacucccc agcccuaaca gacuucacgu ucaugguaaa ggacaccucc uaccuguuca      720

ucacuggccc ugauguugug aagucuguca ccaaugagga uguuacccag gaggagcucg      780

guggugccaa gacccacacc accaugucag guguggccca cagagcuuuu gaaaaugaug      840

uugaugccuu guguaaucuc cgggauuucu ucaacuaccu gccccugagc agucaggacc      900

cggcucccgu ccgugagugc cacgauccca gugaccgucu gguuccugag cuugacacaa      960

uugucccuuu ggaaucaacc aaagccuaca acauggugga caucauacac ucuguuguug     1020

augagcguga auuuuuugag aucaugccca auuaugccaa gaacaucauu guugguuuug     1080

caagaaugaa ugggaggacu guuggaauug uuggcaacca accuaaggug gccucaggau     1140

gcuuggauau uaauucaucu gugaaagggg cucguuuugu cagauucugu gaugcauuca     1200

auauuccacu caucacuuuu guugaugucc cuggcuuucu accuggcaca gcacaggaau     1260

acgggggcau cauccggcau ggugccaagc uucucuacgc auuugcugag gcaacuguac     1320

ccaaagucac agucaucacc aggaaggccu auggaggugc cuaugauguc augagcucua     1380

agcaccuuug uggugauacc aacuaugccu ggcccaccgc agagauugca gucaugggag     1440

caaagggcgc uguggagauc aucuucaaag ggcaugagaa uguggaagcu gcucaggcag     1500

aguacaucga gaaguuugcc aacccuuucc cugcagcagu gcgaggguuu guggaugaca     1560

ucauccaacc uucuuccaca cgugcccgaa ucugcuguga ccuggauguc uuggccagca     1620

agaagguaca acguccuugg agaaaacaug caaauauucc auuguaagcg gccgcuuaau     1680

uaagcugccu ucugcggggc uugccuucug gccaugcccu ucuucucucc cuugcaccug     1740

uaccucuugg ucuuugaaua aagccugagu aggaag                               1776


