                         SEQUENCE LISTING

<110>  VIVOSCRIPT, INC.,
 
<120>  TRANSDUCIBLE MATERIALS FOR CELL REPROGRAMMING

<130>  037125-8013WO01

<150>  US 61/958,493
<151>  2013-07-29

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  2
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Asp Glu Val Ala Gly Gly Ala Arg Lys Ala Thr Lys Ser 
1               5                   10                  15      


Lys Leu Phe Glu Phe Leu Val His Gly Val Arg Pro Gly Met Pro Ser 
            20                  25                  30          


Gly Ala Arg Met Pro His Gln Gly Ala Pro Met Gly Pro Pro Gly Ser 
        35                  40                  45              


Pro Tyr Met Gly Ser Pro Ala Val Arg Pro Gly Leu Ala Pro Ala Gly 
    50                  55                  60                  


Met Glu Pro Ala Arg Lys Arg Ala Ala Pro Pro Pro Gly Gln Ser Gln 
65                  70                  75                  80  


Ala Gln Ser Gln Gly Gln Pro Val Pro Thr Ala Pro Ala Arg Ser Arg 
                85                  90                  95      


Ser Ala Lys Arg Arg Lys Met Ala Asp Lys Ile Leu Pro Gln Arg Ile 
            100                 105                 110         


Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe 
        115                 120                 125             


Glu Arg Lys Leu Asp Gln Thr Ile Met Arg Lys Arg Val Asp Ile Gln 
    130                 135                 140                 


Glu Ala Leu Lys Arg Pro Met Lys Gln Lys Arg Lys Leu Arg Leu Tyr 
145                 150                 155                 160 


Ile Ser Asn Thr Phe Asn Pro Ala Lys Pro Asp Ala Glu Asp Ser Asp 
                165                 170                 175     


Gly Ser Ile Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
            180                 185                 190         


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
        195                 200                 205             


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
    210                 215                 220                 


Glu Trp His Arg Thr Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
225                 230                 235                 240 


Lys Arg Pro Gly Asp Leu Ser Val Arg Cys Thr Leu Leu Leu Met Leu 
                245                 250                 255     


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Leu Ala Arg Leu 
            260                 265                 270         


Leu Gly Leu His Thr Gln Ser Arg Ser Ala Ile Val Gln Ala Leu Trp 
        275                 280                 285             


Gln Tyr Val Lys Thr Asn Arg Leu Gln Asp Ser His Asp Lys Glu Tyr 
    290                 295                 300                 


Ile Asn Gly Asp Lys Tyr Phe Gln Gln Ile Phe Asp Cys Pro Arg Leu 
305                 310                 315                 320 


Lys Phe Ser Glu Ile Pro Gln Arg Leu Thr Ala Leu Leu Leu Pro Pro 
                325                 330                 335     


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Ser Asp Gln 
            340                 345                 350         


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Glu Glu Pro Leu 
        355                 360                 365             


Lys Gly Gln Met Ser Ser Phe Leu Leu Ser Thr Ala Asn Gln Gln Glu 
    370                 375                 380                 


Ile Ser Ala Leu Asp Ser Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
385                 390                 395                 400 


Gln Leu Lys Ile Gln Arg Asp Phe Met Leu Ser Phe Ser Arg Asp Pro 
                405                 410                 415     


Lys Gly Tyr Val Gln Asp Leu Leu Arg Ser Gln Ser Arg Asp Leu Lys 
            420                 425                 430         


Val Met Thr Asp Val Ala Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
        435                 440                 445             


Phe Tyr His Gln Pro Trp Ser Gln Glu Ala Val Ser Arg Tyr Phe Tyr 
    450                 455                 460                 


Cys Lys Ile Gln Gln Arg Arg Gln Glu Leu Glu Gln Ser Leu Val Val 
465                 470                 475                 480 


Arg Asn Thr 
            


<210>  3
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
145                 150                 155                 160 


His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His 
                165                 170                 175     


Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
            180                 185                 190         


Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
        195                 200                 205             


Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
    210                 215                 220                 


Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                245                 250                 255     


Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
            260                 265                 270         


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
        275                 280                 285             


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
    290                 295                 300                 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
305                 310                 315                 320 


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                325                 330                 335     


Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
            340                 345                 350         


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
        355                 360                 365             


Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
    370                 375                 380                 


Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
385                 390                 395                 400 


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                405                 410                 415     


Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
            420                 425                 430         


Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440             


<210>  4
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Ala Ala Ser Asn Pro Tyr Ser Ile Leu Ser Ser Thr Ser 
1               5                   10                  15      


Leu Val His Ala Asp Ser Ala Gly Met Gln Gln Gly Ser Pro Phe Arg 
            20                  25                  30          


Asn Pro Gln Lys Leu Leu Gln Ser Asp Tyr Leu Gln Gly Val Pro Ser 
        35                  40                  45              


Asn Gly His Pro Leu Gly His His Trp Val Thr Ser Leu Ser Asp Gly 
    50                  55                  60                  


Gly Pro Trp Ser Ser Thr Leu Ala Thr Ser Pro Leu Asp Gln Gln Asp 
65                  70                  75                  80  


Val Lys Pro Gly Arg Glu Asp Leu Gln Leu Gly Ala Ile Ile His His 
                85                  90                  95      


Arg Ser Pro His Val Ala His His Ser Pro His Thr Asn His Pro Asn 
            100                 105                 110         


Ala Trp Gly Ala Ser Pro Ala Pro Asn Pro Ser Ile Thr Ser Ser Gly 
        115                 120                 125             


Gln Pro Leu Asn Val Tyr Ser Gln Pro Gly Phe Thr Val Ser Gly Met 
    130                 135                 140                 


Leu Glu His Gly Gly Leu Thr Pro Pro Pro Ala Ala Ala Ser Ala Gln 
145                 150                 155                 160 


Ser Leu His Pro Val Leu Arg Glu Pro Pro Asp His Gly Glu Leu Gly 
                165                 170                 175     


Ser His His Cys Gln Asp His Ser Asp Glu Glu Thr Pro Thr Ser Asp 
            180                 185                 190         


Glu Leu Glu Gln Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu 
        195                 200                 205             


Gly Phe Thr Gln Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly 
    210                 215                 220                 


Asn Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
225                 230                 235                 240 


Ser Phe Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu 
                245                 250                 255     


Glu Glu Ala Asp Ser Ser Thr Gly Ser Pro Thr Ser Ile Asp Lys Ile 
            260                 265                 270         


Ala Ala Gln Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser 
        275                 280                 285             


Val Lys Gly Val Leu Glu Thr His Phe Leu Lys Cys Pro Lys Pro Ala 
    290                 295                 300                 


Ala Gln Glu Ile Ser Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu 
305                 310                 315                 320 


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met 
                325                 330                 335     


Thr Pro Pro Gly Asp Gln Gln Pro His Glu Val Tyr Ser His Thr Val 
            340                 345                 350         


Lys Thr Asp Thr Ser Cys His Asp Leu 
        355                 360     


<210>  5
<211>  1954
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Gly Pro Val Gly Thr Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Thr Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Thr Val Thr Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Thr Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Thr Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Thr Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Thr Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Thr Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Thr Pro Ile Val Asp Pro Thr Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Thr Gly Gly Thr Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp 
705                 710                 715                 720 


Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Gln Thr Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Thr Tyr Thr Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Thr Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Thr 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Thr  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Thr  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Thr  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Thr Ala Asp 
    1100                 1105                 1110             


Thr Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Asn  Lys Lys Val 
    1130                 1135                 1140             


Met Ile  Tyr Arg Phe Val Thr  Arg Ala Ser Val Glu  Glu Arg Ile 
    1145                 1150                 1155             


Thr Gln  Val Ala Lys Arg Lys  Met Met Leu Thr His  Leu Val Val 
    1160                 1165                 1170             


Arg Pro  Gly Leu Gly Ser Lys  Ser Gly Ser Met Thr  Lys Gln Glu 
    1175                 1180                 1185             


Leu Asp  Asp Ile Leu Lys Phe  Gly Thr Glu Glu Leu  Phe Lys Asp 
    1190                 1195                 1200             


Asp Val  Glu Gly Met Met Ser  Gln Gly Gln Arg Pro  Val Thr Pro 
    1205                 1210                 1215             


Ile Pro  Asp Val Gln Ser Ser  Lys Gly Gly Asn Leu  Ala Ala Ser 
    1220                 1225                 1230             


Ala Lys  Lys Lys His Gly Ser  Thr Pro Pro Gly Asp  Asn Lys Asp 
    1235                 1240                 1245             


Val Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Ala  Ala Ile Ser 
    1250                 1255                 1260             


Lys Leu  Leu Asp Arg Asn Gln  Asp Ala Thr Asp Asp  Thr Glu Leu 
    1265                 1270                 1275             


Gln Asn  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1280                 1285                 1290             


Val Val  Arg Glu Glu Asp Gly  Val Glu Glu Val Glu  Arg Glu Ile 
    1295                 1300                 1305             


Ile Lys  Gln Glu Glu Asn Val  Asp Pro Asp Tyr Trp  Glu Lys Leu 
    1310                 1315                 1320             


Leu Arg  His His Tyr Glu Gln  Gln Gln Glu Asp Leu  Ala Arg Asn 
    1325                 1330                 1335             


Leu Gly  Lys Gly Lys Arg Ile  Arg Lys Gln Val Asn  Tyr Asn Asp 
    1340                 1345                 1350             


Ala Ser  Gln Glu Asp Gln Glu  Trp Gln Asp Glu Leu  Ser Asp Asn 
    1355                 1360                 1365             


Gln Ser  Glu Tyr Ser Ile Gly  Ser Glu Asp Glu Asp  Glu Asp Phe 
    1370                 1375                 1380             


Glu Glu  Arg Pro Glu Gly Gln  Ser Gly Arg Arg Gln  Ser Arg Arg 
    1385                 1390                 1395             


Gln Leu  Lys Ser Asp Arg Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1400                 1405                 1410             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1415                 1420                 1425             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Trp Gly  Met Pro Pro 
    1430                 1435                 1440             


Gln Asp  Ala Phe Asn Ser His  Trp Leu Val Arg Asp  Leu Arg Gly 
    1445                 1450                 1455             


Lys Ser  Glu Lys Glu Phe Arg  Ala Tyr Val Ser Leu  Phe Met Arg 
    1460                 1465                 1470             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Thr  Phe Ala Asp 
    1475                 1480                 1485             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Thr Arg 
    1490                 1495                 1500             


Ile Gly  Val Met Ser Leu Val  Arg Lys Lys Val Gln  Glu Phe Glu 
    1505                 1510                 1515             


His Val  Asn Gly Lys Tyr Ser  Thr Pro Asp Leu Ile  Pro Glu Gly 
    1520                 1525                 1530             


Pro Glu  Gly Lys Lys Ser Gly  Glu Val Ile Ser Ser  Asp Pro Asn 
    1535                 1540                 1545             


Thr Pro  Val Pro Ala Ser Pro  Ala His Leu Leu Pro  Ala Pro Leu 
    1550                 1555                 1560             


Gly Leu  Pro Asp Lys Met Glu  Ala Gln Leu Gly Tyr  Met Asp Glu 
    1565                 1570                 1575             


Lys Asp  Pro Gly Ala Gln Lys  Pro Arg Gln Pro Leu  Glu Val Gln 
    1580                 1585                 1590             


Ala Leu  Pro Ala Ala Leu Asp  Arg Val Glu Ser Glu  Asp Lys His 
    1595                 1600                 1605             


Glu Ser  Pro Ala Ser Lys Glu  Arg Ala Arg Glu Glu  Arg Pro Glu 
    1610                 1615                 1620             


Glu Thr  Glu Lys Ala Pro Pro  Ser Pro Glu Gln Leu  Pro Arg Glu 
    1625                 1630                 1635             


Glu Val  Leu Pro Glu Lys Glu  Lys Ile Leu Asp Lys  Leu Glu Leu 
    1640                 1645                 1650             


Ser Leu  Ile His Ser Arg Gly  Asp Ser Ser Glu Leu  Arg Pro Asp 
    1655                 1660                 1665             


Asp Thr  Lys Ala Glu Glu Lys  Glu Pro Ile Glu Thr  Gln Gln Asn 
    1670                 1675                 1680             


Gly Asp  Lys Glu Glu Asp Asp  Glu Gly Lys Lys Glu  Asp Lys Lys 
    1685                 1690                 1695             


Gly Lys  Phe Lys Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Thr 
    1700                 1705                 1710             


Glu Leu  His Thr Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Val Ser 
    1715                 1720                 1725             


Ser Gly  Lys Ile Tyr Asp Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1730                 1735                 1740             


Leu Leu  Ala Gly Ile Val Thr  His Gly Tyr Ala Arg  Trp Gln Asp 
    1745                 1750                 1755             


Ile Gln  Asn Asp Pro Arg Tyr  Met Ile Leu Asn Glu  Pro Phe Lys 
    1760                 1765                 1770             


Ser Glu  Val His Lys Gly Asn  Tyr Leu Glu Met Lys  Asn Lys Phe 
    1775                 1780                 1785             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1790                 1795                 1800             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Met Thr  Gln Asp Pro 
    1805                 1810                 1815             


Asn His  Pro Ala Met Ala Leu  Asn Ala Arg Leu Ala  Glu Val Glu 
    1820                 1825                 1830             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1835                 1840                 1845             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1850                 1855                 1860             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Thr Arg Leu 
    1865                 1870                 1875             


Pro Ser  Met Leu Ser Arg Ile  Pro Pro Val Ala Ala  Arg Leu Gln 
    1880                 1885                 1890             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Thr Asn  Arg Ala Gly 
    1895                 1900                 1905             


Asp Pro  Thr Ile Gln Gln Gly  Ala Phe Gly Ser Ser  Gln Met Tyr 
    1910                 1915                 1920             


Ser Asn  Asn Phe Gly Pro Asn  Phe Arg Gly Pro Gly  Pro Gly Gly 
    1925                 1930                 1935             


Ile Val  Asn Tyr Asn Gln Met  Pro Leu Gly Pro Tyr  Val Thr Asp 
    1940                 1945                 1950             


Ile 
    


<210>  6
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  7
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Met Thr Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly 
1               5                   10                  15      


Lys Ala Val Phe Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro 
            20                  25                  30          


Ser Pro Met Ser His Gly His Tyr Ser Met His Cys Leu His Ser Ala 
        35                  40                  45              


Gly His Ser Gln Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser 
    50                  55                  60                  


Arg Pro Leu Gly Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser 
65                  70                  75                  80  


Ser Pro Tyr Ile Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu 
                85                  90                  95      


Ala Gln Ser Arg Leu Glu Asp Pro Gly Ala Asp Ser Glu Lys Ser Thr 
            100                 105                 110         


Val Val Glu Gly Gly Glu Val Arg Phe Asn Gly Lys Gly Lys Lys Ile 
        115                 120                 125             


Arg Lys Pro Arg Thr Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn 
    130                 135                 140                 


Arg Arg Phe Gln Gln Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu 
145                 150                 155                 160 


Leu Ala Ala Ser Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn Lys Arg Ser Lys Phe Lys Lys Leu Met Lys Gln Gly Gly Ala 
            180                 185                 190         


Ala Leu Glu Gly Ser Ala Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly 
        195                 200                 205             


Ser Pro Pro Val Pro Pro Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys 
    210                 215                 220                 


Gly Ser Gly Gly Asn Ala Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Trp 
225                 230                 235                 240 


Tyr Pro Ser Ala His Gln Glu Ala Met Gln Gln Pro Gln Leu Met 
                245                 250                 255 


<210>  8
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Ala Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His 
        35                  40                  45              


Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser 
    50                  55                  60                  


Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly 
                85                  90                  95      


Leu Asn Asn Val Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr 
            100                 105                 110         


Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro 
        115                 120                 125             


Ala Asn Asn Glu Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile 
    130                 135                 140                 


Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr 
                165                 170                 175     


Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu Thr 
            180                 185                 190         


Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys 
        195                 200                 205             


Lys Met Trp Lys Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala 
    210                 215                 220                 


Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser 
225                 230                 235                 240 


Trp Asp Phe Gly Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala 
            260                 265                 270         


Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly 
        275                 280                 285             


Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln 
    290                 295                 300                 


Thr Pro Gln Pro His His His His His His His Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Pro Val Ser Ala Gly Thr Ile Phe 
                325             


<210>  9
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  10
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu 
        35                  40                  45              


Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu His Met Gln 
    210                 215                 220                 


Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu 
225                 230                 235                 240 


Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu Pro 
                245                 250                 255     


Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu Val 
            260                 265                 270         


Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly Leu 
        275                 280                 285             


Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser 
    290                 295                 300                 


Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln Ser 
305                 310                 315                 320 


Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr Gly 
                325                 330                 335     


Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys 
            340                 345                 350         


Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn Asn 
        355                 360                 365             


Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met 
    370                 375                 380                 


Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg 
385                 390                 395                 400 


Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro Lys 
                405                 410                 415     


Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser Lys 
            420                 425                 430         


Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr 
        435                 440                 445             


Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr 
    450                 455                 460                 


Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp 
465                 470                 475                 480 


Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe 
                485                 490                 495     


Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile 
            500                 505                 510         


Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu 
        515                 520                 525             


Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala 
    530                 535                 540                 


Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys 
545                 550                 555                 560 


Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu 
                565                 570                 575     


Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr 
            580                 585                 590         


Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn 
        595                 600                 605             


Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser 
    610                 615                 620                 


Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val 
625                 630                 635                 640 


His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn 
                645                 650                 655     


Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His Val 
            660                 665                 670         


Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu 
        675                 680                 685             


Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile 
    690                 695                 700                 


Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 


<210>  11
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Arg Ser Val Asp Arg Ala Gly Lys Asp Pro Arg Pro 
            180                 185                 190         


Pro Ile Pro Ser Pro Asp Thr Leu Cys Pro Pro Ser Thr Leu Ser Ala 
        195                 200                 205             


Val Pro Gln Ser Ser Tyr Pro Leu Leu Ala Asn Gly Val Cys Lys Trp 
    210                 215                 220                 


Pro Gly Cys Glu Lys Val Phe Glu Glu Pro Glu Asp Phe Leu Lys His 
225                 230                 235                 240 


Cys Gln Ala Asp His Leu Leu Asp Glu Lys Gly Arg Ala Gln Cys Leu 
                245                 250                 255     


Leu Gln Arg Glu Met Val Gln Ser Leu Glu Gln Gln Leu Val Leu Glu 
            260                 265                 270         


Lys Glu Lys Leu Ser Ala Met Gln Ala His Leu Ala Gly Lys Met Ala 
        275                 280                 285             


Leu Thr Lys Ala Ser Ser Val Ala Ser Ser Asp Lys Gly Ser Cys Cys 
    290                 295                 300                 


Ile Val Ala Ala Gly Ser Gln Gly Pro Val Val Pro Ala Trp Ser Gly 
305                 310                 315                 320 


Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala Val Arg Arg His Leu Trp 
                325                 330                 335     


Gly Ser His Gly Asn Ser Thr Phe Pro Glu Phe Leu His Asn Met Asp 
            340                 345                 350         


Tyr Phe Lys Phe His Asn Met Arg Pro Pro Phe Thr Tyr Ala Thr Leu 
        355                 360                 365             


Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln Arg Thr Leu Asn 
    370                 375                 380                 


Glu Ile Tyr His Trp Phe Thr Arg Met Phe Ala Phe Phe Arg Asn His 
385                 390                 395                 400 


Pro Ala Thr Trp Lys Asn Ala Ile Arg His Asn Leu Ser Leu His Lys 
                405                 410                 415     


Cys Phe Val Arg Val Glu Ser Glu Lys Gly Ala Val Trp Thr Val Asp 
            420                 425                 430         


Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro Ser Arg Cys Ser 
        435                 440                 445             


Asn Pro Thr Pro Gly Pro 
    450                 


<210>  12
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Val Asp Met 
        195                 200                 205             


Phe Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met 
    210                 215                 220                 


Ser Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn 
225                 230                 235                 240 


Ala Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile 
                245                 250                 255     


Lys Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys 
            260                 265                 270         


Ala Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu 
        275                 280                 285             


Gly Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly 
    290                 295                 300                 


Val Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys 
305                 310                 315                 320 


Arg Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser 
                325                 330                 335     


Gly Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser 
            340                 345                 350         


Asn Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu 
        355                 360                 365             


Pro Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr 
    370                 375                 380                 


Phe Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val 
385                 390                 395                 400 


Leu Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser 
                405                 410                 415     


Gln Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val 
            420                 425                 430         


Leu Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440             


<210>  13
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asn Leu Val Gly Ser Tyr Ala His His His His His His His Pro 
1               5                   10                  15      


His Pro Ala His Pro Met Leu His Glu Pro Phe Leu Phe Gly Pro Ala 
            20                  25                  30          


Ser Arg Cys His Gln Glu Arg Pro Tyr Phe Gln Ser Trp Leu Leu Ser 
        35                  40                  45              


Pro Ala Asp Ala Ala Pro Asp Phe Pro Ala Gly Gly Pro Pro Pro Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Thr Ala Tyr Gly Pro Asp Ala Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Gly Arg Leu Glu Ala Leu Gly Gly Arg Leu Gly Arg Arg Lys 
                85                  90                  95      


Gly Ser Gly Pro Lys Lys Glu Arg Arg Arg Thr Glu Ser Ile Asn Ser 
            100                 105                 110         


Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr 
        115                 120                 125             


Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala Thr Ser Tyr Ile Ala 
    130                 135                 140                 


Tyr Leu Met Asp Val Leu Ala Lys Asp Ala Gln Ser Gly Asp Pro Glu 
145                 150                 155                 160 


Ala Phe Lys Ala Glu Leu Lys Lys Ala Asp Gly Gly Arg Glu Ser Lys 
                165                 170                 175     


Arg Lys Arg Glu Leu Gln Gln His Glu Gly Phe Pro Pro Ala Leu Gly 
            180                 185                 190         


Pro Val Glu Lys Arg Ile Lys Gly Arg Thr Gly Trp Pro Gln Gln Val 
        195                 200                 205             


Trp Ala Leu Glu Leu Asn Gln 
    210                 215 


<210>  14
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Ala Asp Ile Met Glu Lys Asn Ser Ser Ser Pro Val Ala Ala 
1               5                   10                  15      


Thr Pro Ala Ser Val Asn Thr Thr Pro Asp Lys Pro Lys Thr Ala Ser 
            20                  25                  30          


Glu His Arg Lys Ser Ser Lys Pro Ile Met Glu Lys Arg Arg Arg Ala 
        35                  40                  45              


Arg Ile Asn Glu Ser Leu Ser Gln Leu Lys Thr Leu Ile Leu Asp Ala 
    50                  55                  60                  


Leu Lys Lys Asp Ser Ser Arg His Ser Lys Leu Glu Lys Ala Asp Ile 
65                  70                  75                  80  


Leu Glu Met Thr Val Lys His Leu Arg Asn Leu Gln Arg Ala Gln Met 
                85                  90                  95      


Thr Ala Ala Leu Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr Arg Ala 
            100                 105                 110         


Gly Phe Ser Glu Cys Met Asn Glu Val Thr Arg Phe Leu Ser Thr Cys 
        115                 120                 125             


Glu Gly Val Asn Thr Glu Val Arg Thr Arg Leu Leu Gly His Leu Ala 
    130                 135                 140                 


Asn Cys Met Thr Gln Ile Asn Ala Met Thr Tyr Pro Gly Gln Pro His 
145                 150                 155                 160 


Pro Ala Leu Gln Ala Pro Pro Pro Pro Pro Pro Gly Pro Gly Gly Pro 
                165                 170                 175     


Gln His Ala Pro Phe Ala Pro Pro Pro Pro Leu Val Pro Ile Pro Gly 
            180                 185                 190         


Gly Ala Ala Pro Pro Pro Gly Gly Ala Pro Cys Lys Leu Gly Ser Gln 
        195                 200                 205             


Ala Gly Glu Ala Ala Lys Val Phe Gly Gly Phe Gln Val Val Pro Ala 
    210                 215                 220                 


Pro Asp Gly Gln Phe Ala Phe Leu Ile Pro Asn Gly Ala Phe Ala His 
225                 230                 235                 240 


Ser Gly Pro Val Ile Pro Val Tyr Thr Ser Asn Ser Gly Thr Ser Val 
                245                 250                 255     


Gly Pro Asn Ala Val Ser Pro Ser Ser Gly Pro Ser Leu Thr Ala Asp 
            260                 265                 270         


Ser Met Trp Arg Pro Trp Arg Asn 
        275                 280 


<210>  15
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Pro Ser Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys 
1               5                   10                  15      


Asn Arg Leu Arg Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile 
            20                  25                  30          


Asn Ser Ser Ile Glu Gln Leu Lys Leu Leu Leu Glu Gln Glu Phe Ala 
        35                  40                  45              


Arg His Gln Pro Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met 
    50                  55                  60                  


Ala Val Ser Tyr Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Lys Ser Leu His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu 
                85                  90                  95      


Gln Glu Ala Val Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln 
            100                 105                 110         


Met Lys Leu Leu Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Lys Glu Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu 
    130                 135                 140                 


Ser Ala Lys Ala Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Trp Arg Pro Trp 
                165     


<210>  16
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


<210>  17
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Phe His Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp 
1               5                   10                  15      


Glu Met Asp Arg Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala 
            20                  25                  30          


Ile Asp Arg Gly Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp 
        35                  40                  45              


Arg Ala Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr 
    50                  55                  60                  


Tyr Leu Leu Ala Val Asp Lys Gln Trp His Met Arg Cys Leu Lys Cys 
65                  70                  75                  80  


Cys Glu Cys Lys Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys 
                85                  90                  95      


Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val 
            100                 105                 110         


Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val 
        115                 120                 125             


Met Arg Ala Arg Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr 
    130                 135                 140                 


Thr Cys Asn Lys Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp 
145                 150                 155                 160 


Ser Leu Val Tyr Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu 
                165                 170                 175     


Tyr Pro Ala His Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro 
        195                 200                 205             


Leu Gly Leu Pro Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg 
    210                 215                 220                 


Pro Arg Lys Arg Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr 
225                 230                 235                 240 


Asn Ala Ala Leu Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg 
                245                 250                 255     


Asp Gln Pro Tyr Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser 
            260                 265                 270         


Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn 
        275                 280                 285             


His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly 
    290                 295                 300                 


Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys 
305                 310                 315                 320 


Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser 
                325                 330                 335     


Thr Asp Ala Ala Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu 
            340                 345                 350         


Leu Ser Asn Ala Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr 
        355                 360                 365             


Asp Leu Thr Ser Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser 
    370                 375                 380                 


Val Pro Gly Asn Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr 
385                 390                 395                 400 


Thr Leu Thr Asn Leu Phe 
                405     


<210>  18
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  19
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210>  20
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  21
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Gln Pro Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser 
1               5                   10                  15      


Ala Ala Trp Gly Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys 
            20                  25                  30          


Gly Arg Ser Leu Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala 
        35                  40                  45              


Asp Ser Pro Val Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro 
    50                  55                  60                  


Arg Ala Pro Ser Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly 
65                  70                  75                  80  


Ser Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg 
                85                  90                  95      


Thr Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser 
            100                 105                 110         


Val Ala Pro Ala Gly Gln Ser Leu Thr Lys Ile Glu Thr Leu Arg Leu 
        115                 120                 125             


Ala Ile Arg Tyr Ile Gly His Leu Ser Ala Val Leu Gly Leu Ser Glu 
    130                 135                 140                 


Glu Ser Leu Gln Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro 
145                 150                 155                 160 


Arg Gly Cys Pro Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr 
                165                 170                 175     


Arg Thr Gln Ala Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val 
            180                 185                 190         


Ser Ala Val Arg Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro 
        195                 200                 205             


Gly Ala Arg Ala Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala 
    210                 215                 220                 


Glu Ala Ala Cys Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser 
225                 230                 235                 240 


Pro Leu Leu Pro Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro 
                245                 250                 255     


Leu Ser Pro Leu Glu Trp Leu Pro Glu Glu Pro Lys 
            260                 265             


<210>  22
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Val Asp Leu Thr Ala Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
    50                  55                  60                  


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
            180                 185                 190         


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
        195                 200                 205             


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
    210                 215                 220                 


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
225                 230                 235                 240 


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
                245                 250                 255     


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
            260                 265                 270         


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
        275                 280                 285             


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
    290                 295                 300                 


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
305                 310                 315                 320 


<210>  23
<211>  1184
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly 
1               5                   10                  15      


Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro 
            20                  25                  30          


Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg 
        35                  40                  45              


His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln 
    50                  55                  60                  


Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 
65                  70                  75                  80  


Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr 
                85                  90                  95      


Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu 
            100                 105                 110         


Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp 
        115                 120                 125             


Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu 
    130                 135                 140                 


Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His 
                165                 170                 175     


Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp 
            180                 185                 190         


Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu 
        195                 200                 205             


Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu 
    210                 215                 220                 


Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn 
225                 230                 235                 240 


Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp 
                245                 250                 255     


Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His 
            260                 265                 270         


Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser 
        275                 280                 285             


Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys 
    290                 295                 300                 


Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu 
305                 310                 315                 320 


Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp 
                325                 330                 335     


Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln 
            340                 345                 350         


Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro 
        355                 360                 365             


Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg 
    370                 375                 380                 


Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala 
385                 390                 395                 400 


Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn 
                405                 410                 415     


Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr 
            420                 425                 430         


Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met 
        435                 440                 445             


Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser 
    450                 455                 460                 


Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro 
465                 470                 475                 480 


Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg 
                485                 490                 495     


Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr 
            500                 505                 510         


Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys 
        515                 520                 525             


Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser 
    530                 535                 540                 


Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn 
545                 550                 555                 560 


Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala 
                565                 570                 575     


Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val 
            580                 585                 590         


Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe 
        595                 600                 605             


Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro 
    610                 615                 620                 


Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser 
625                 630                 635                 640 


Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys 
                645                 650                 655     


Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly 
            660                 665                 670         


Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser 
        675                 680                 685             


Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly 
    690                 695                 700                 


Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr 
705                 710                 715                 720 


Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn 
                725                 730                 735     


Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro 
            740                 745                 750         


Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp Glu Asn 
        755                 760                 765             


Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys 
    770                 775                 780                 


Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala 
785                 790                 795                 800 


Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys Trp Asp 
                805                 810                 815     


Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp Glu Asp 
            820                 825                 830         


Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala 
        835                 840                 845             


Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys 
    850                 855                 860                 


Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu 
865                 870                 875                 880 


Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr 
                885                 890                 895     


Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly 
            900                 905                 910         


His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro 
        915                 920                 925             


Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys 
    930                 935                 940                 


Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln 
945                 950                 955                 960 


Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys 
                965                 970                 975     


Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln 
            980                 985                 990         


Phe Ser Trp Lys Ser Val Lys Thr  Glu Gly Met Ser Cys  Pro Thr Pro 
        995                 1000                 1005             


Gly Cys  Asp Gly Ser Gly His  Val Ser Gly Ser Phe  Leu Thr His 
    1010                 1015                 1020             


Arg Ser  Leu Ser Gly Cys Pro  Arg Ala Thr Ser Ala  Met Lys Lys 
    1025                 1030                 1035             


Ala Lys  Leu Ser Gly Glu Gln  Met Leu Thr Ile Lys  Gln Arg Ala 
    1040                 1045                 1050             


Ser Asn  Gly Ile Glu Asn Asp  Glu Glu Ile Lys Gln  Leu Asp Glu 
    1055                 1060                 1065             


Glu Ile  Lys Glu Leu Asn Glu  Ser Asn Ser Gln Met  Glu Ala Asp 
    1070                 1075                 1080             


Met Ile  Lys Leu Arg Thr Gln  Ile Thr Thr Met Glu  Ser Asn Leu 
    1085                 1090                 1095             


Lys Thr  Ile Glu Glu Glu Asn  Lys Val Ile Glu Gln  Gln Asn Glu 
    1100                 1105                 1110             


Ser Leu  Leu His Glu Leu Ala  Asn Leu Ser Gln Ser  Leu Ile His 
    1115                 1120                 1125             


Ser Leu  Ala Asn Ile Gln Leu  Pro His Met Asp Pro  Ile Asn Glu 
    1130                 1135                 1140             


Gln Asn  Phe Asp Ala Tyr Val  Thr Thr Leu Thr Glu  Met Tyr Thr 
    1145                 1150                 1155             


Asn Gln  Asp Arg Tyr Gln Ser  Pro Glu Asn Lys Ala  Leu Leu Glu 
    1160                 1165                 1170             


Asn Ile  Lys Gln Ala Val Arg  Gly Ile Gln Val 
    1175                 1180                 


<210>  24
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  25
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Glu Ser Glu Asn Arg Lys Glu Leu Ser Glu Ser Ser Gln Glu 
1               5                   10                  15      


Glu Ala Gly Asn Gln Ile Met Val Glu Gly Leu Gly Glu His Leu Glu 
            20                  25                  30          


Arg Gly Glu Asp Ala Ala Ala Gly Leu Gly Asp Asp Gly Lys Cys Gly 
        35                  40                  45              


Glu Glu Ala Ala Ala Gly Leu Gly Glu Glu Gly Glu Asn Gly Glu Asp 
    50                  55                  60                  


Thr Ala Ala Gly Ser Gly Glu Asp Gly Lys Lys Gly Gly Asp Thr Asp 
65                  70                  75                  80  


Glu Asp Ser Glu Ala Asp Arg Pro Lys Gly Leu Ile Gly Tyr Val Leu 
                85                  90                  95      


Asp Thr Asp Phe Val Glu Ser Leu Pro Val Lys Val Lys Tyr Arg Val 
            100                 105                 110         


Leu Ala Leu Lys Lys Leu Gln Thr Arg Ala Ala Asn Leu Glu Ser Lys 
        115                 120                 125             


Phe Leu Arg Glu Phe His Asp Ile Glu Arg Lys Phe Ala Glu Met Tyr 
    130                 135                 140                 


Gln Pro Leu Leu Glu Lys Arg Arg Gln Ile Ile Asn Ala Ile Tyr Glu 
145                 150                 155                 160 


Pro Thr Glu Glu Glu Cys Glu Tyr Lys Ser Asp Ser Glu Asp Cys Asp 
                165                 170                 175     


Asp Glu Glu Met Cys His Glu Glu Met Tyr Gly Asn Glu Glu Gly Met 
            180                 185                 190         


Val His Glu Tyr Val Asp Glu Asp Asp Gly Tyr Glu Asp Tyr Tyr Tyr 
        195                 200                 205             


Asp Tyr Ala Val Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ile 
    210                 215                 220                 


Glu Ala Thr Gly Glu Glu Asn Lys Glu Glu Glu Asp Pro Lys Gly Ile 
225                 230                 235                 240 


Pro Asp Phe Trp Leu Thr Val Leu Lys Asn Val Asp Thr Leu Thr Pro 
                245                 250                 255     


Leu Ile Lys Lys Tyr Asp Glu Pro Ile Leu Lys Leu Leu Thr Asp Ile 
            260                 265                 270         


Lys Val Lys Leu Ser Asp Pro Gly Glu Pro Leu Ser Phe Thr Leu Glu 
        275                 280                 285             


Phe His Phe Lys Pro Asn Glu Tyr Phe Lys Asn Glu Leu Leu Thr Lys 
    290                 295                 300                 


Thr Tyr Val Leu Lys Ser Lys Leu Ala Tyr Tyr Asp Pro His Pro Tyr 
305                 310                 315                 320 


Arg Gly Thr Ala Ile Glu Tyr Ser Thr Gly Cys Glu Ile Asp Trp Asn 
                325                 330                 335     


Glu Gly Lys Asn Val Thr Leu Lys Thr Ile Lys Lys Lys Gln Lys His 
            340                 345                 350         


Arg Ile Trp Gly Thr Ile Arg Thr Val Thr Glu Asp Phe Pro Lys Asp 
        355                 360                 365             


Ser Phe Phe Asn Phe Phe Ser Pro His Gly Ile Thr Ser Asn Gly Arg 
    370                 375                 380                 


Asp Gly Asn Asp Asp Phe Leu Leu Gly His Asn Leu Arg Thr Tyr Ile 
385                 390                 395                 400 


Ile Pro Arg Ser Val Leu Phe Phe Ser Gly Asp Ala Leu Glu Ser Gln 
                405                 410                 415     


Gln Glu Gly Val Val Arg Glu Val Asn Asp Ala Ile Tyr Asp Lys Ile 
            420                 425                 430         


Ile Tyr Asp Asn Trp Met Ala Ala Ile Glu Glu Val Lys Ala Cys Cys 
        435                 440                 445             


Lys Asn Leu Glu Ala Leu Val Glu Asp Ile Asp Arg 
    450                 455                 460 


<210>  26
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  27
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Thr Arg Leu Phe Ser Glu Pro Gly Leu Leu Ser Asp Val Pro 
1               5                   10                  15      


Lys Phe Ala Ser Trp Gly Asp Gly Glu Asp Asp Glu Pro Arg Ser Asp 
            20                  25                  30          


Lys Gly Asp Ala Pro Pro Pro Pro Pro Pro Ala Pro Gly Pro Gly Ala 
        35                  40                  45              


Pro Gly Pro Ala Arg Ala Ala Lys Pro Val Pro Leu Arg Gly Glu Glu 
    50                  55                  60                  


Gly Thr Glu Ala Thr Leu Ala Glu Val Lys Glu Glu Gly Glu Leu Gly 
65                  70                  75                  80  


Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Leu Asp Glu Ala 
                85                  90                  95      


Glu Gly Glu Arg Pro Lys Lys Arg Gly Pro Lys Lys Arg Lys Met Thr 
            100                 105                 110         


Lys Ala Arg Leu Glu Arg Ser Lys Leu Arg Arg Gln Lys Ala Asn Ala 
        115                 120                 125             


Arg Glu Arg Asn Arg Met His Asp Leu Asn Ala Ala Leu Asp Asn Leu 
    130                 135                 140                 


Arg Lys Val Val Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile 
145                 150                 155                 160 


Glu Thr Leu Arg Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile 
                165                 170                 175     


Leu Arg Ser Gly Lys Arg Pro Asp Leu Val Ser Tyr Val Gln Thr Leu 
            180                 185                 190         


Cys Lys Gly Leu Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu 
        195                 200                 205             


Gln Leu Asn Ser Arg Asn Phe Leu Thr Glu Gln Gly Ala Asp Gly Ala 
    210                 215                 220                 


Gly Arg Phe His Gly Ser Gly Gly Pro Phe Ala Met His Pro Tyr Pro 
225                 230                 235                 240 


Tyr Pro Cys Ser Arg Leu Ala Gly Ala Gln Cys Gln Ala Ala Gly Gly 
                245                 250                 255     


Leu Gly Gly Gly Ala Ala His Ala Leu Arg Thr His Gly Tyr Cys Ala 
            260                 265                 270         


Ala Tyr Glu Thr Leu Tyr Ala Ala Ala Gly Gly Gly Gly Ala Ser Pro 
        275                 280                 285             


Asp Tyr Asn Ser Ser Glu Tyr Glu Gly Pro Leu Ser Pro Pro Leu Cys 
    290                 295                 300                 


Leu Asn Gly Asn Phe Ser Leu Lys Gln Asp Ser Ser Pro Asp His Glu 
305                 310                 315                 320 


Lys Ser Tyr His Tyr Ser Met His Tyr Ser Ala Leu Pro Gly Ser Arg 
                325                 330                 335     


Pro Thr Gly His Gly Leu Val Phe Gly Ser Ser Ala Val Arg Gly Gly 
            340                 345                 350         


Val His Ser Glu Asn Leu Leu Ser Tyr Asp Met His Leu His His Asp 
        355                 360                 365             


Arg Gly Pro Met Tyr Glu Glu Leu Asn Ala Phe Phe His Asn 
    370                 375                 380         


<210>  28
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Asp Val 
1               5                   10                  15      


Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 
            20                  25                  30          


Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 
        35                  40                  45              


Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 
    50                  55                  60                  


Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 
            180                 185                 190         


Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 
        195                 200                 205             


Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 
    210                 215                 220                 


Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 
225                 230                 235                 240 


Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 
                245                 250                 255     


Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 
            260                 265                 270         


<210>  29
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Thr Pro Gln Pro Ser Gly Ala Pro Thr Val Gln Val Thr Arg Glu 
1               5                   10                  15      


Thr Glu Arg Ser Phe Pro Arg Ala Ser Glu Asp Glu Val Thr Cys Pro 
            20                  25                  30          


Thr Ser Ala Pro Pro Ser Pro Thr Arg Thr Arg Gly Asn Cys Ala Glu 
        35                  40                  45              


Ala Glu Glu Gly Gly Cys Arg Gly Ala Pro Arg Lys Leu Arg Ala Arg 
    50                  55                  60                  


Arg Gly Gly Arg Ser Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln 
65                  70                  75                  80  


Arg Arg Ser Arg Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met 
                85                  90                  95      


His Asn Leu Asn Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr 
            100                 105                 110         


Phe Pro Asp Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala 
        115                 120                 125             


His Asn Tyr Ile Trp Ala Leu Thr Gln Thr Leu Arg Ile Ala Asp His 
    130                 135                 140                 


Ser Leu Tyr Ala Leu Glu Pro Pro Ala Pro His Cys Gly Glu Leu Gly 
145                 150                 155                 160 


Ser Pro Gly Gly Ser Pro Gly Asp Trp Gly Ser Leu Tyr Ser Pro Val 
                165                 170                 175     


Ser Gln Ala Gly Ser Leu Ser Pro Ala Ala Ser Leu Glu Glu Arg Pro 
            180                 185                 190         


Gly Leu Leu Gly Ala Thr Phe Ser Ala Cys Leu Ser Pro Gly Ser Leu 
        195                 200                 205             


Ala Phe Ser Asp Phe Leu 
    210                 


<210>  30
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Met Leu Ser Pro Asp Gln Ala Ala Asp Ser Asp His Pro Ser Ser 
1               5                   10                  15      


Ala His Ser Asp Pro Glu Ser Leu Gly Gly Thr Asp Thr Lys Val Leu 
            20                  25                  30          


Gly Ser Val Ser Asp Leu Glu Pro Val Glu Glu Ala Glu Gly Asp Gly 
        35                  40                  45              


Lys Gly Gly Ser Arg Ala Ala Leu Tyr Pro His Pro Gln Gln Leu Ser 
    50                  55                  60                  


Arg Glu Glu Lys Arg Arg Arg Arg Arg Ala Thr Ala Lys Tyr Arg Ser 
65                  70                  75                  80  


Ala His Ala Thr Arg Glu Arg Ile Arg Val Glu Ala Phe Asn Leu Ala 
                85                  90                  95      


Phe Ala Glu Leu Arg Lys Leu Leu Pro Thr Leu Pro Pro Asp Lys Lys 
            100                 105                 110         


Leu Ser Lys Ile Glu Ile Leu Arg Leu Ala Ile Cys Tyr Ile Ser Tyr 
        115                 120                 125             


Leu Asn His Val Leu Asp Val 
    130                 135 


<210>  31
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Glu Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Asn Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Leu Asp Ala Val Gln Ser Leu Pro Leu Lys Asn Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Gly Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro 
            100                 105                 110         


Asp Asn Asp Lys Glu Thr Pro Gly Gly Gly Gly Asp Ala Gly Lys Lys 
        115                 120                 125             


Arg Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu 
    130                 135                 140                 


Arg Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His 
145                 150                 155                 160 


Leu Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met 
            180                 185                 190         


Glu Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu 
        195                 200                 205             


Val Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala 
    210                 215                 220                 


Ala Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln 
225                 230                 235                 240 


Ser Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr 
                245                 250                 255     


Pro Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr 
            260                 265                 270         


Trp 
    


<210>  32
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp 
1               5                   10                  15      


Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu 
            20                  25                  30          


Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu 
        35                  40                  45              


Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro 
    50                  55                  60                  


Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala 
65                  70                  75                  80  


Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala 
                85                  90                  95      


Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu 
            100                 105                 110         


Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp 
        115                 120                 125             


Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu 
    130                 135                 140                 


Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln 
145                 150                 155                 160 


Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Leu Ala Ser Val Leu Lys 
                165                 170                 175     


Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys 
            180                 185                 190         


Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro 
        195                 200                 205             


Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val 
    210                 215                 220                 


Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala 
225                 230                 235                 240 


Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr 
                245                 250                 255     


Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala 
            260                 265                 270         


Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala 
        275                 280                 285             


Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln 
    290                 295                 300                 


Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly 
305                 310                 315                 320 


Ile Arg Ala Trp 
                


<210>  33
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Ala Val Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Leu 
1               5                   10                  15      


Leu Ser Ser Pro Pro Leu Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Thr His Asn Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr 
                165                 170                 175     


Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys 
            180                 185                 190         


Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val 
        195                 200                 205             


Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His 
    210                 215                 220                 


Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg 
225                 230                 235                 240 


Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu 
                245                 250                 255     


Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser 
            260                 265                 270         


Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg 
        275                 280                 285             


Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys 
    290                 295                 300                 


Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp 
                325                 330                 335     


Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Gly Leu Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser 
        355                 360                 365         


<210>  34
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Tyr Arg Ser Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile 
1               5                   10                  15      


Asn Ala Glu Ile Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala 
            20                  25                  30          


Asp Lys Val Arg Leu Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile 
        35                  40                  45              


Tyr Thr Arg Lys Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly 
    50                  55                  60                  


Pro Thr Gly Leu Leu Ser Ala Gln Glu Leu Glu Asp Ile Val Ala Ala 
65                  70                  75                  80  


Leu Pro Gly Phe Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr 
                85                  90                  95      


Leu Ser Glu Ser Val Ser Glu His Leu Gly His Ser Met Val Asp Leu 
            100                 105                 110         


Val Ala Gln Gly Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His 
        115                 120                 125             


Leu Thr Val Arg Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp 
    130                 135                 140                 


Arg Leu Phe Arg Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln 
145                 150                 155                 160 


Ser Ala Gly Asn Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His 
                165                 170                 175     


Pro Pro Gly Ala Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys 
            180                 185                 190         


Ala Pro Leu Glu Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly 
        195                 200                 205             


Pro Ala Ser Leu Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp 
    210                 215                 220                 


Leu Ala Leu Leu Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe 
225                 230                 235                 240 


Glu Arg Ser Glu Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro 
                245                 250                 255     


Glu Asp Leu Ala His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu 
            260                 265                 270         


Ser Gly Asp Ile Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr 
        275                 280                 285             


Gly Gly Trp Ala Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu 
    290                 295                 300                 


Gly Pro Ile Thr Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp 
305                 310                 315                 320 


Ser Leu Arg Gln Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val 
                325                 330                 335     


Leu Gly Thr Pro Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser 
            340                 345                 350         


Gln Glu Glu Cys Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly 
        355                 360                 365             


Ala Pro Arg Ser Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val 
    370                 375                 380                 


Ser Ala Ser Glu Glu Leu Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser 
385                 390                 395                 400 


Tyr Leu Thr Phe Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu 
                405                 410                 415     


Ser Lys Asp Leu Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly 
            420                 425                 430         


Gly Cys Ala Phe Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu 
        435                 440                 445             


Pro Thr Pro Ser Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala 
    450                 455                 460                 


Thr Phe Ser Asp Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro 
465                 470                 475                 480 


Leu Thr Ser Pro Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser 
                485                 490                 495     


Tyr Glu Asp Gln Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu 
            500                 505                 510         


Leu Pro Ser Thr Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His 
        515                 520                 525             


Glu Gln Leu Thr Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser 
    530                 535                 540                 


Pro Ser Gln Thr Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr 
545                 550                 555                 560 


Tyr Phe Ala Gln Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro 
                565                 570                 575     


Ser Pro Ser Ser Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala 
            580                 585                 590         


Gln Leu Arg Gly Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly 
        595                 600                 605             


Leu Leu Thr Pro Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr 
    610                 615                 620                 


Ser Glu Lys Glu Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser 
625                 630                 635                 640 


Gln Leu Ala Gln Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr 
                645                 650                 655     


Gly Gly Leu Glu Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu 
            660                 665                 670         


Ser Leu Ser Gly Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro 
        675                 680                 685             


Trp Lys Cys Gln Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe 
    690                 695                 700                 


Leu Glu Glu Thr Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro 
705                 710                 715                 720 


Asp Pro Ser Glu Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro 
                725                 730                 735     


Gly Gly Ala Pro Ser Pro Cys Asn Asn Leu Ser Pro Glu Asp His Ser 
            740                 745                 750         


Phe Leu Glu Asp Leu Ala Thr Tyr Glu Thr Ala Phe Glu Thr Gly Val 
        755                 760                 765             


Ser Ala Phe Pro Tyr Asp Gly Phe Thr Asp Glu Leu His Gln Leu Gln 
    770                 775                 780                 


Ser Gln Val Gln Asp Ser Phe His Glu Asp Gly Ser Gly Gly Glu Pro 
785                 790                 795                 800 


Thr Phe 
        


<210>  35
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Phe Tyr Ser Gly Leu Leu Thr Glu Gly Gly Arg Lys Glu Thr Asp 
1               5                   10                  15      


Met Arg Glu Ala Ala Ser Leu Arg Gln Gln Arg Arg Met Lys Gln Ala 
            20                  25                  30          


Val Gln Phe Ile His Lys Asp Ser Ala Asp Leu Leu Pro Leu Asp Gly 
        35                  40                  45              


Leu Lys Lys Leu Gly Ser Ser Lys Asp Met Gln Pro His Asn Ile Leu 
    50                  55                  60                  


Gln Arg Arg Leu Met Glu Thr Asn Leu Ser Lys Leu Arg Ser Gly Pro 
65                  70                  75                  80  


Arg Val Pro Trp Ala Ser Lys Thr Asn Lys Leu Asn Gln Ala Lys Ser 
                85                  90                  95      


Glu Gly Leu Lys Lys Ser Glu Glu Asp Asp Met Ile Leu Val Ser Cys 
            100                 105                 110         


Gln Cys Ala Gly Lys Asp Val Lys Ala Leu Val Asp Thr Gly Cys Leu 
        115                 120                 125             


Tyr Asn Leu Ile Ser Leu Ala Cys Val Asp Arg Leu Gly Leu Lys Glu 
    130                 135                 140                 


His Val Lys Ser His Lys His Glu Gly Glu Lys Leu Ser Leu Pro Arg 
145                 150                 155                 160 


His Leu Lys Val Val Gly Gln Ile Glu His Leu Val Ile Thr Leu Gly 
                165                 170                 175     


Ser Leu Arg Leu Asp Cys Pro Ala Ala Val Val Asp Asp Asn Glu Lys 
            180                 185                 190         


Asn Leu Ser Leu Gly Leu Gln Thr Leu Arg Ser Leu Lys Cys Ile Ile 
        195                 200                 205             


Asn Leu Asp Lys His Arg Leu Ile Met Gly Lys Thr Asp Lys Glu Glu 
    210                 215                 220                 


Ile Pro Phe Val Glu Thr Val Ser Leu Asn Glu Asp Asn Thr Ser Glu 
225                 230                 235                 240 


Ala 
    


<210>  36
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  37
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Leu Gln Gln Leu Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210>  38
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  39
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ala Leu Pro Gly Thr Val Pro Arg Met Met Arg Pro Ala Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp 
    130                 135                 140                 


Arg Ser Thr Val Pro Ser Gly Leu Val Ser Ser Ile Ser Arg Val Leu 
145                 150                 155                 160 


Arg Ile Lys Phe Gly Lys Lys Glu Glu Glu Asp Glu Ala Asp Lys Lys 
                165                 170                 175     


Glu Asp Asp Gly Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Gly Asp Lys Gly Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu 
        195                 200                 205             


Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe 
    210                 215                 220                 


Thr Ala Glu Gln Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His 
225                 230                 235                 240 


Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu 
                245                 250                 255     


Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp 
            260                 265                 270         


Arg Lys Gln Ala Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu 
        275                 280                 285             


Pro Gly Gly Phe Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln 
    290                 295                 300                 


Leu Pro Asp Ser Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly 
305                 310                 315                 320 


Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln 
                325                 330                 335     


Gly Gly Leu Ala Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr 
            340                 345                 350         


Gly Ala Arg His Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro 
        355                 360                 365             


Ala Ala Pro Ser Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Pro 
    370                 375                 380                 


Gln Val Met Ser Ile Leu Gly Asn Pro Ser Ala Val Pro Pro Gln Pro 
385                 390                 395                 400 


Gln Ala Asp Phe Ser Ile Ser Pro Leu His Gly Gly Leu Asp Ser Ala 
                405                 410                 415     


Thr Ser Ile Ser Ala Ser Cys Ser Gln Arg Ala Asp Ser Ile Lys Pro 
            420                 425                 430         


Gly Asp Ser Leu Pro Thr Ser Gln Ala Tyr Cys Pro Pro Thr Tyr Ser 
        435                 440                 445             


Thr Thr Gly Tyr Ser Val Asp Pro Val Ala Gly Tyr Gln Tyr Gly Gln 
    450                 455                 460                 


Tyr Gly Gln Ser Glu Cys Leu Val Pro Trp Ala Ser Pro Val Pro Ile 
465                 470                 475                 480 


Pro Ser Pro Thr Pro Arg Ala Ser Cys Leu Phe Met Glu Ser Tyr Lys 
                485                 490                 495     


Val Val Ser Gly Trp Gly Met Ser Ile Ser Gln Met Glu Lys Leu Lys 
            500                 505                 510         


Ser Ser Gln Met Glu Gln Phe Thr 
        515                 520 


<210>  40
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro 
                245                 


<210>  41
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Asp Thr Gly Ile Gln Arg Gly Ile Trp Asp Gly Asp Ala Lys 
1               5                   10                  15      


Ala Val Gln Gln Cys Leu Thr Asp Ile Phe Thr Ser Val Tyr Thr Thr 
            20                  25                  30          


Cys Asp Ile Pro Glu Asn Ala Ile Phe Gly Pro Cys Val Leu Ser His 
        35                  40                  45              


Thr Ser Leu Tyr Asp Ser Ile Ala Phe Ile Ala Leu Lys Ser Thr Asp 
    50                  55                  60                  


Lys Arg Thr Val Pro Tyr Ile Phe Arg Val Asp Thr Ser Ala Ala Asn 
65                  70                  75                  80  


Gly Ser Ser Glu Gly Leu Met Trp Leu Arg Leu Val Gln Ser Ala Arg 
                85                  90                  95      


Asp Lys Glu Glu Gln Asn Leu Glu Ala Tyr Ile Lys Asn Gly Gln Leu 
            100                 105                 110         


Phe Tyr Arg Ser Leu Arg Arg Ile Ala Lys Asp Glu Glu Leu Leu Val 
        115                 120                 125             


Trp Tyr Gly Lys Glu Leu Thr Glu Leu Leu Leu Leu Cys Pro Ser Arg 
    130                 135                 140                 


Ser His Asn Lys Met Asn Gly Ser Ser Pro Tyr Thr Cys Leu Glu Cys 
145                 150                 155                 160 


Ser Gln Arg Phe Gln Phe Glu Phe Pro Tyr Val Ala His Leu Arg Phe 
                165                 170                 175     


Arg Cys Pro Lys Arg Leu His Ser Ala Asp Ile Ser Pro Gln Asp Glu 
            180                 185                 190         


Gln Gly Gly Gly Val Gly Thr Lys Asp His Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Lys Asp Gln Gln Gln Gln Gln Gln Glu Ala Pro Leu Gly Pro Gly 
    210                 215                 220                 


Pro Lys Phe Cys Lys Ala Gly Pro Leu His His Tyr Pro Ser Pro Ser 
225                 230                 235                 240 


Pro Glu Ser Ser Asn Pro Ser Ala Ala Ala Gly Gly Ser Ser Ala Lys 
                245                 250                 255     


Pro Ser Thr Asp Phe His Asn Leu Ala Arg Glu Leu Glu Asn Ser Arg 
            260                 265                 270         


Gly Gly Ser Ser Cys Ser Pro Ala Gln Ser Leu Ser Ser Gly Ser Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Gly His Gln Glu Ala Glu Leu Ser Pro Asp Gly 
    290                 295                 300                 


Ile Ala Thr Gly Gly Gly Lys Gly Lys Arg Lys Phe Pro Glu Glu Ala 
305                 310                 315                 320 


Ala Glu Gly Gly Gly Gly Ala Gly Leu Val Gly Gly Arg Gly Arg Phe 
                325                 330                 335     


Val Glu Arg Pro Leu Pro Ala Ser Lys Glu Asp Leu Val Cys Thr Pro 
            340                 345                 350         


Gln Gln Tyr Arg Ala Ser Gly Ser Tyr Phe Gly Leu Glu Glu Asn Gly 
        355                 360                 365             


Arg Leu Phe Ala Pro Pro Ser Pro Glu Thr Gly Glu Ala Lys Arg Ser 
    370                 375                 380                 


Ala Phe Val Glu Val Lys Lys Ala Ala Arg Ala Ala Ser Leu Gln Glu 
385                 390                 395                 400 


Glu Gly Thr Ala Asp Gly Ala Gly Val Ala Ser Glu Asp Gln Asp Ala 
                405                 410                 415     


Gly Gly Gly Gly Gly Ser Ser Thr Pro Ala Ala Ala Ser Pro Val Gly 
            420                 425                 430         


Ala Glu Lys Leu Leu Ala Pro Arg Pro Gly Gly Pro Leu Pro Ser Arg 
        435                 440                 445             


Leu Glu Gly Gly Ser Pro Ala Arg Gly Ser Ala Phe Thr Ser Val Pro 
    450                 455                 460                 


Gln Leu Gly Ser Ala Gly Ser Thr Ser Gly Gly Gly Gly Thr Gly Ala 
465                 470                 475                 480 


Gly Ala Ala Gly Gly Ala Gly Gly Gly Gln Gly Ala Ala Ser Asp Glu 
                485                 490                 495     


Arg Lys Ser Ala Phe Ser Gln Pro Ala Arg Ser Phe Ser Gln Leu Ser 
            500                 505                 510         


Pro Leu Val Leu Gly Gln Lys Leu Gly Ala Leu Glu Pro Cys His Pro 
        515                 520                 525             


Ala Asp Gly Val Gly Pro Thr Arg Leu Tyr Pro Ala Ala Ala Asp Pro 
    530                 535                 540                 


Leu Ala Val Lys Leu Gln Gly Ala Ala Asp Leu Asn Gly Gly Cys Gly 
545                 550                 555                 560 


Ser Leu Pro Ser Gly Gly Gly Gly Leu Pro Lys Gln Ser Pro Phe Leu 
                565                 570                 575     


Tyr Ala Thr Ala Phe Trp Pro Lys Ser Ser Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Ala Ala Ala Ala Gly Pro Leu Gln Leu Gln Leu Pro Ser Ala 
        595                 600                 605             


Leu Thr Leu Leu Pro Pro Ser Phe Thr Ser Leu Cys Leu Pro Ala Gln 
    610                 615                 620                 


Asn Trp Cys Ala Lys Cys Asn Ala Ser Phe Arg Met Thr Ser Asp Leu 
625                 630                 635                 640 


Val Tyr His Met Arg Ser His His Lys Lys Glu Tyr Ala Met Glu Pro 
                645                 650                 655     


Leu Val Lys Arg Arg Arg Glu Glu Lys Leu Lys Cys Pro Ile Cys Asn 
            660                 665                 670         


Glu Ser Phe Arg Glu Arg His His Leu Ser Arg His Met Thr Ser His 
        675                 680                 685             


Asn 
    


<210>  42
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Arg Arg Ser Glu Ser Pro Cys Leu Arg Asp Ser Pro Asp Arg 
1               5                   10                  15      


Arg Ser Gly Ser Pro Asp Val Lys Gly Pro Pro Pro Val Lys Val Ala 
            20                  25                  30          


Arg Leu Glu Gln Asn Gly Ser Pro Met Gly Ala Arg Gly Arg Pro Asn 
        35                  40                  45              


Gly Ala Val Ala Lys Ala Val Gly Gly Leu Met Ile Pro Val Phe Cys 
    50                  55                  60                  


Val Val Glu Gln Leu Asp Gly Ser Leu Glu Tyr Asp Asn Arg Glu Glu 
65                  70                  75                  80  


His Ala Glu Phe Val Leu Val Arg Lys Asp Val Leu Phe Ser Gln Leu 
                85                  90                  95      


Val Glu Thr Ala Leu Leu Ala Leu Gly Tyr Ser His Ser Ser Ala Ala 
            100                 105                 110         


Gln Ala Gln Gly Ile Ile Lys Leu Gly Arg Trp Asn Pro Leu Pro Leu 
        115                 120                 125             


Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln 
    130                 135                 140                 


Asp Val Tyr His Val Val Thr Leu Lys Ile Gln Leu Gln Ser Cys Ser 
145                 150                 155                 160 


Lys Leu Glu Asp Leu Pro Ala Glu Gln Trp Asn His Ala Thr Val Arg 
                165                 170                 175     


Asn Ala Leu Lys Glu Leu Leu Lys Glu Met Asn Gln Ser Thr Leu Ala 
            180                 185                 190         


Lys Glu Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser 
        195                 200                 205             


Thr Tyr Tyr Ala Asn Val Ser Ala Thr Lys Cys Gln Glu Phe Gly Arg 
    210                 215                 220                 


Trp Tyr Lys Lys Tyr Lys Lys Ile Lys Val Glu Arg Val Glu Arg Glu 
225                 230                 235                 240 


Asn Leu Ser Asp Tyr Cys Val Leu Gly Gln Arg Pro Met His Leu Pro 
                245                 250                 255     


Asn Met Asn Gln Leu Ala Ser Leu Gly Lys Thr Asn Glu Gln Ser Pro 
            260                 265                 270         


His Ser Gln Ile His His Ser Thr Pro Ile Arg Asn Gln Val Pro Ala 
        275                 280                 285             


Leu Gln Pro Ile Met Ser Pro Gly Leu Leu Ser Pro Gln Leu Ser Pro 
    290                 295                 300                 


Gln Leu Val Arg Gln Gln Ile Ala Met Ala His Leu Ile Asn Gln Gln 
305                 310                 315                 320 


Ile Ala Val Ser Arg Leu Leu Ala His Gln His Pro Gln Ala Ile Asn 
                325                 330                 335     


Gln Gln Phe Leu Asn His Pro Pro Ile Pro Arg Ala Val Lys Pro Glu 
            340                 345                 350         


Pro Thr Asn Ser Ser Val Glu Val Ser Pro Asp Ile Tyr Gln Gln Val 
        355                 360                 365             


Arg Asp Glu Leu Lys Arg Ala Ser Val Ser Gln Ala Val Phe Ala Arg 
    370                 375                 380                 


Val Ala Phe Asn Arg Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys 
385                 390                 395                 400 


Glu Glu Asp Pro Arg Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg 
                405                 410                 415     


Ala Met Gln Asn Phe Leu Asn Leu Pro Glu Val Glu Arg Asp Arg Ile 
            420                 425                 430         


Tyr Gln Asp Glu Arg Glu Arg Ser Met Asn Pro Asn Val Ser Met Val 
        435                 440                 445             


Ser Ser Ala Ser Ser Ser Pro Ser Ser Ser Arg Thr Pro Gln Ala Lys 
    450                 455                 460                 


Thr Ser Thr Pro Thr Thr Asp Leu Pro Ile Lys Val Asp Gly Ala Asn 
465                 470                 475                 480 


Ile Asn Ile Thr Ala Ala Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys 
                485                 490                 495     


Arg Ala Lys Val Ser Gln Ala Leu Phe Ala Lys Val Ala Ala Asn Lys 
            500                 505                 510         


Ser Gln Gly Trp Leu Cys Glu Leu Leu Arg Trp Lys Glu Asn Pro Ser 
        515                 520                 525             


Pro Glu Asn Arg Thr Leu Trp Glu Asn Leu Cys Thr Ile Arg Arg Phe 
    530                 535                 540                 


Leu Asn Leu Pro Gln His Glu Arg Asp Val Ile Tyr Glu Glu Glu Ser 
545                 550                 555                 560 


Arg His His His Ser Glu Arg Met Gln His Val Val Gln Leu Pro Pro 
                565                 570                 575     


Glu Pro Val Gln Val Leu His Arg Gln Gln Ser Gln Pro Ala Lys Glu 
            580                 585                 590         


Ser Ser Pro Pro Arg Glu Glu Ala Pro Pro Pro Pro Pro Pro Thr Glu 
        595                 600                 605             


Asp Ser Cys Ala Lys Lys Pro Arg Ser Arg Thr Lys Ile Ser Leu Glu 
    610                 615                 620                 


Ala Leu Gly Ile Leu Gln Ser Phe Ile His Asp Val Gly Leu Tyr Pro 
625                 630                 635                 640 


Asp Gln Glu Ala Ile His Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys 
                645                 650                 655     


His Thr Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr His Val Lys His 
            660                 665                 670         


His Gly Lys Leu Lys Glu His Leu Gly Ser Ala Val Asp Val Ala Glu 
        675                 680                 685             


Tyr Lys Asp Glu Glu Leu Leu Thr Glu Ser Glu Glu Asn Asp Ser Glu 
    690                 695                 700                 


Glu Gly Ser Glu Glu Met Tyr Lys Val Glu Ala Glu Glu Glu Asn Ala 
705                 710                 715                 720 


Asp Lys Ser Lys Ala Ala Pro Ala Glu Ile Asp Gln Arg 
                725                 730             


<210>  43
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Glu Leu Thr Ala Phe Val Ser Lys Ser Phe Asp Gln Lys Val 
1               5                   10                  15      


Lys Glu Lys Lys Glu Ala Ile Thr Tyr Arg Glu Val Leu Glu Ser Gly 
            20                  25                  30          


Pro Leu Arg Gly Ala Lys Glu Pro Thr Gly Cys Thr Glu Ala Gly Arg 
        35                  40                  45              


Asp Asp Arg Ser Ser Pro Ala Val Arg Ala Ala Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly 
65                  70                  75                  80  


Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Arg Ser Pro Val Arg Glu 
                85                  90                  95      


Leu Asp Met Gly Ala Ala Glu Arg Ser Arg Glu Pro Gly Ser Pro Arg 
            100                 105                 110         


Leu Thr Glu Gly Arg Arg Lys Pro Thr Lys Ala Glu Val Gln Ala Thr 
        115                 120                 125             


Leu Leu Leu Pro Gly Glu Ala Phe Arg Phe Leu Val Ser Pro Glu Leu 
    130                 135                 140                 


Lys Asp Arg Lys Glu Asp Ala Lys Gly Met Glu Asp Glu Gly Gln Thr 
145                 150                 155                 160 


Lys Ile Lys Gln Arg Arg Ser Arg Thr Asn Phe Thr Leu Glu Gln Leu 
                165                 170                 175     


Asn Glu Leu Glu Arg Leu Phe Asp Glu Thr His Tyr Pro Asp Ala Phe 
            180                 185                 190         


Met Arg Glu Glu Leu Ser Gln Arg Leu Gly Leu Ser Glu Ala Arg Val 
        195                 200                 205             


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Cys Arg Lys Gln Glu Asn 
    210                 215                 220                 


Gln Leu His Lys Gly Val Leu Ile Gly Ala Ala Ser Gln Phe Glu Ala 
225                 230                 235                 240 


Cys Arg Val Ala Pro Tyr Val Asn Val Gly Ala Leu Arg Met Pro Phe 
                245                 250                 255     


Gln Gln Asp Ser His Cys Asn Val Thr Pro Leu Ser Phe Gln Val Gln 
            260                 265                 270         


Ala Gln Leu Gln Leu Asp Ser Ala Val Ala His Ala His His His Leu 
        275                 280                 285             


His Pro His Leu Ala Ala His Ala Pro Tyr Met Met Phe Pro Ala Pro 
    290                 295                 300                 


Pro Phe Gly Leu Pro Leu Ala Thr Leu Ala Ala Asp Ser Ala Ser Ala 
305                 310                 315                 320 


Ala Ser Val Val Ala Ala Ala Ala Ala Ala Lys Thr Thr Ser Lys Asn 
                325                 330                 335     


Ser Ser Ile Ala Asp Leu Arg Leu Lys Ala Lys Lys His Ala Ala Ala 
            340                 345                 350         


Leu Gly Leu 
        355 


<210>  44
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  45
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Asn Leu Leu Asp Pro Phe Met Lys Met Thr Asp Glu Gln Glu Lys 
1               5                   10                  15      


Gly Leu Ser Gly Ala Pro Ser Pro Thr Met Ser Glu Asp Ser Ala Gly 
            20                  25                  30          


Ser Pro Cys Pro Ser Gly Ser Gly Ser Asp Thr Glu Asn Thr Arg Pro 
        35                  40                  45              


Gln Glu Asn Thr Phe Pro Lys Gly Glu Pro Asp Leu Lys Lys Glu Ser 
    50                  55                  60                  


Glu Glu Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val 
65                  70                  75                  80  


Leu Lys Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn 
                85                  90                  95      


Gly Ser Ser Lys Asn Lys Pro His Val Lys Arg Pro Met Asn Ala Phe 
            100                 105                 110         


Met Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro 
        115                 120                 125             


His Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg 
    130                 135                 140                 


Leu Leu Asn Glu Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Arg Val Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro 
                165                 170                 175     


Arg Arg Arg Lys Ser Val Lys Asn Gly Gln Ala Glu Ala Glu Glu Ala 
            180                 185                 190         


Thr Glu Gln Thr His Ile Ser Pro Asn Ala Ile Phe Lys Ala Leu Gln 
        195                 200                 205             


Ala Asp Ser Pro His Ser Ser Ser Gly Met Ser Glu Val His Ser Pro 
    210                 215                 220                 


Gly Glu His Ser Gly Gln Ser Gln Gly Pro Pro Thr Pro Pro Thr Thr 
225                 230                 235                 240 


Pro Lys Thr Asp Val Gln Pro Gly Lys Ala Asp Leu Lys Arg Glu Gly 
                245                 250                 255     


Arg Pro Leu Pro Glu Gly Gly Arg Gln Pro Pro Ile Asp Phe Arg Asp 
            260                 265                 270         


Val Asp Ile Gly Glu Leu Ser Ser Asp Val Ile Ser Asn Ile Glu Thr 
        275                 280                 285             


Phe Asp Val Asn Glu Phe Asp Gln Tyr Leu Pro Pro Asn Gly His Pro 
    290                 295                 300                 


Gly Val Pro Ala Thr His Gly Gln Val Thr Tyr Thr Gly Ser Tyr Gly 
305                 310                 315                 320 


Ile Ser Ser Thr Ala Ala Thr Pro Ala Ser Ala Gly His Val Trp Met 
                325                 330                 335     


Ser Lys Gln Gln Ala Pro Pro Pro Pro Pro Gln Gln Pro Pro Gln Ala 
            340                 345                 350         


Pro Pro Ala Pro Gln Ala Pro Pro Gln Pro Gln Ala Ala Pro Pro Gln 
        355                 360                 365             


Gln Pro Ala Ala Pro Pro Gln Gln Pro Gln Ala His Thr Leu Thr Thr 
    370                 375                 380                 


Leu Ser Ser Glu Pro Gly Gln Ser Gln Arg Thr His Ile Lys Thr Glu 
385                 390                 395                 400 


Gln Leu Ser Pro Ser His Tyr Ser Glu Gln Gln Gln His Ser Pro Gln 
                405                 410                 415     


Gln Ile Ala Tyr Ser Pro Phe Asn Leu Pro His Tyr Ser Pro Ser Tyr 
            420                 425                 430         


Pro Pro Ile Thr Arg Ser Gln Tyr Asp Tyr Thr Asp His Gln Asn Ser 
        435                 440                 445             


Ser Ser Tyr Tyr Ser His Ala Ala Gly Gln Gly Thr Gly Leu Tyr Ser 
    450                 455                 460                 


Thr Phe Thr Tyr Met Asn Pro Ala Gln Arg Pro Met Tyr Thr Pro Ile 
465                 470                 475                 480 


Ala Asp Thr Ser Gly Val Pro Ser Ile Pro Gln Thr His Ser Pro Gln 
                485                 490                 495     


His Trp Glu Gln Pro Val Tyr Thr Gln Leu Thr Arg Pro 
            500                 505                 


<210>  46
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gln Leu Glu His Cys Leu Ser Pro Ser Ile Met Leu Ser Lys Lys 
1               5                   10                  15      


Phe Leu Asn Val Ser Ser Ser Tyr Pro His Ser Gly Gly Ser Glu Leu 
            20                  25                  30          


Val Leu His Asp His Pro Ile Ile Ser Thr Thr Asp Asn Leu Glu Arg 
        35                  40                  45              


Ser Ser Pro Leu Lys Lys Ile Thr Arg Gly Met Thr Asn Gln Ser Asp 
    50                  55                  60                  


Thr Asp Asn Phe Pro Asp Ser Lys Asp Ser Pro Gly Asp Val Gln Arg 
65                  70                  75                  80  


Ser Lys Leu Ser Pro Val Leu Asp Gly Val Ser Glu Leu Arg His Ser 
                85                  90                  95      


Phe Asp Gly Ser Ala Ala Asp Arg Tyr Leu Leu Ser Gln Ser Ser Gln 
            100                 105                 110         


Pro Gln Ser Ala Ala Thr Ala Pro Ser Ala Met Phe Pro Tyr Pro Gly 
        115                 120                 125             


Gln His Gly Pro Ala His Pro Ala Phe Ser Ile Gly Ser Pro Ser Arg 
    130                 135                 140                 


Tyr Met Ala His His Pro Val Ile Thr Asn Gly Ala Tyr Asn Ser Leu 
145                 150                 155                 160 


Leu Ser Asn Ser Ser Pro Gln Gly Tyr Pro Thr Ala Gly Tyr Pro Tyr 
                165                 170                 175     


Pro Gln Gln Tyr Gly His Ser Tyr Gln Gly Ala Pro Phe Tyr Gln Phe 
            180                 185                 190         


Ser Ser Thr Gln Pro Gly Leu Val Pro Gly Lys Ala Gln Val Tyr Leu 
        195                 200                 205             


Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met 
    210                 215                 220                 


Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn 
225                 230                 235                 240 


Ile Ser Gly Leu Asp Pro Thr Ala His Tyr Asn Ile Phe Val Asp Val 
                245                 250                 255     


Ile Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val 
            260                 265                 270         


Pro Cys Gly Lys Ala Asp Thr Asn Val Gln Gly Asn Arg Val Tyr Met 
        275                 280                 285             


His Pro Asp Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Ile 
    290                 295                 300                 


Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn 
305                 310                 315                 320 


Asn Gly Gln Met Val Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg 
                325                 330                 335     


Leu His Val Val Glu Val Asn Glu Asp Gly Thr Glu Asp Thr Ser Gln 
            340                 345                 350         


Pro Gly Arg Val Gln Thr Phe Thr Phe Pro Glu Thr Gln Phe Ile Ala 
        355                 360                 365             


Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His 
    370                 375                 380                 


Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Thr Ile Tyr Thr 
385                 390                 395                 400 


Gly Cys Asp Met Asp Arg Leu Thr Pro Ser Pro Asn Asp Ser Pro Arg 
                405                 410                 415     


Ser Gln Ile Val Pro Gly Ala Arg Tyr Ala Met Ala Gly Ser Phe Leu 
            420                 425                 430         


Gln Asp Gln Phe Val Ser Asn Tyr Ala Lys Ala Arg Phe His Pro Gly 
        435                 440                 445             


Ala Gly Ala Gly Pro Gly Pro Gly Thr Asp Arg Ser Val Pro His Thr 
    450                 455                 460                 


Asn Gly Leu Leu Ser Pro Gln Gln Ala Glu Asp Pro Gly Ala Pro Ser 
465                 470                 475                 480 


Pro Gln Arg Trp Phe Val Thr Pro Ala Asn Asn Arg Leu Asp Phe Ala 
                485                 490                 495     


Ala Ser Ala Tyr Asp Thr Ala Thr Asp Phe Ala Gly Asn Ala Ala Thr 
            500                 505                 510         


Leu Leu Ser Tyr Ala Ala Ala Gly Val Lys Ala Leu Pro Leu Gln Ala 
        515                 520                 525             


Ala Gly Cys Thr Gly Arg Pro Leu Gly Tyr Tyr Ala Asp Pro Ser Gly 
    530                 535                 540                 


Trp Gly Ala Arg Ser Pro Pro Gln Tyr Cys Gly Thr Lys Ser Gly Ser 
545                 550                 555                 560 


Val Leu Pro Cys Trp Pro Asn Ser Ala Ala Ala Ala Ala Arg Met Ala 
                565                 570                 575     


Gly Ala Asn Pro Tyr Leu Gly Glu Glu Ala Glu Gly Leu Ala Ala Glu 
            580                 585                 590         


Arg Ser Pro Leu Pro Pro Gly Ala Ala Glu Asp Ala Lys Pro Lys Asp 
        595                 600                 605             


Leu Ser Asp Ser Ser Trp Ile Glu Thr Pro Ser Ser Ile Lys Ser Ile 
    610                 615                 620                 


Asp Ser Ser Asp Ser Gly Ile Tyr Glu Gln Ala Lys Arg Arg Arg Ile 
625                 630                 635                 640 


Ser Pro Ala Asp Thr Pro Val Ser Glu Ser Ser Ser Pro Leu Lys Ser 
                645                 650                 655     


Glu Val Leu Ala Gln Arg Asp Cys Glu Lys Asn Cys Ala Lys Asp Ile 
            660                 665                 670         


Ser Gly Tyr Tyr Gly Phe Tyr Ser His Ser 
        675                 680         


<210>  47
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Asp Ala Asp Glu Ala Leu Ala Gly Ala His Leu Trp Ser Leu 
1               5                   10                  15      


Thr Gln Lys Thr Cys Leu Arg Phe Glu Pro Arg Ala Arg Ser Gly Pro 
            20                  25                  30          


Pro Ala Ser Pro Pro Gly Arg Pro Arg Ser Arg Leu His Pro Ala Gly 
        35                  40                  45              


Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys 
    50                  55                  60                  


Phe His Glu Val Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met 
65                  70                  75                  80  


Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Ile Asn Pro Lys Thr Lys 
                85                  90                  95      


Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys 
            100                 105                 110         


Phe Ala Asp Asn Lys Trp Cys Val Thr Gly Lys Ala Glu Pro Ala Met 
        115                 120                 125             


Ala Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His 
    130                 135                 140                 


Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn Asn 
145                 150                 155                 160 


His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr 
                165                 170                 175     


Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe Gly 
            180                 185                 190         


Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala Phe 
        195                 200                 205             


Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile 
    210                 215                 220                 


Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met Glu 
225                 230                 235                 240 


Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val Pro 
                245                 250                 255     


Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe Ser 
            260                 265                 270         


Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln Tyr 
        275                 280                 285             


Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro Pro 
    290                 295                 300                 


Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His Cys 
305                 310                 315                 320 


Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr Lys 
                325                 330                 335     


Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr Arg 
            340                 345                 350         


Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr Glu 
        355                 360                 365             


Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro Ser 
    370                 375                 380                 


Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro Ser 
385                 390                 395                 400 


Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln Pro Trp Thr 
                405                 410                 415     


Gly Tyr Pro Thr Ser Thr Ser Pro Leu Thr Ser Pro Arg Gly Pro Trp 
            420                 425                 430         


Ser Leu Gly Trp Leu Ala Trp Gln Pro Trp Leu Pro Thr Ala Gly Arg 
        435                 440                 445             


Gly Asn Val Pro Ser Thr Arg Pro Pro Val Ala His Gln Pro Val Val 
    450                 455                 460                 


Ser Ser Val Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu Gln 
465                 470                 475                 480 


Pro Pro Glu Phe Leu Tyr Ser His Gly Val Gln Gly Leu Tyr Pro Leu 
                485                 490                 495     


Ile Ser Thr Thr Leu Cys Thr Glu Leu Ala Trp Cys Arg Val Glu Arg 
            500                 505                 510         


Gln 
    


<210>  48
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Lys Arg Arg Gly Ser Pro Cys Ser Met Leu Ser Leu Lys 
1               5                   10                  15      


Ala His Ala Phe Ser Val Glu Ala Leu Ile Gly Ala Glu Lys Gln Gln 
            20                  25                  30          


Gln Leu Gln Lys Lys Arg Arg Lys Leu Gly Ala Glu Glu Ala Ala Gly 
        35                  40                  45              


Ala Val Asp Asp Gly Gly Cys Ser Arg Gly Gly Gly Ala Gly Glu Lys 
    50                  55                  60                  


Gly Ser Ser Glu Gly Asp Glu Gly Ala Ala Leu Pro Pro Pro Ala Gly 
65                  70                  75                  80  


Ala Thr Ser Gly Pro Ala Arg Ser Gly Ala Asp Leu Glu Arg Gly Ala 
                85                  90                  95      


Ala Gly Gly Cys Glu Asp Gly Phe Gln Gln Gly Ala Ser Pro Leu Ala 
            100                 105                 110         


Ser Pro Gly Gly Ser Pro Lys Gly Ser Pro Ala Arg Ser Leu Ala Arg 
        115                 120                 125             


Pro Gly Thr Pro Leu Pro Ser Pro Gln Ala Pro Arg Val Asp Leu Gln 
    130                 135                 140                 


Gly Ala Glu Leu Trp Lys Arg Phe His Glu Ile Gly Thr Glu Met Ile 
145                 150                 155                 160 


Ile Thr Lys Ala Gly Arg Arg Met Phe Pro Ala Met Arg Val Lys Ile 
                165                 170                 175     


Ser Gly Leu Asp Pro His Gln Gln Tyr Tyr Ile Ala Met Asp Ile Val 
            180                 185                 190         


Pro Val Asp Asn Lys Arg Tyr Arg Tyr Val Tyr His Ser Ser Lys Trp 
        195                 200                 205             


Met Val Ala Gly Asn Ala Asp Ser Pro Val Pro Pro Arg Val Tyr Ile 
    210                 215                 220                 


His Pro Asp Ser Pro Ala Ser Gly Glu Thr Trp Met Arg Gln Val Ile 
225                 230                 235                 240 


Ser Phe Asp Lys Leu Lys Leu Thr Asn Asn Glu Leu Asp Asp Gln Gly 
                245                 250                 255     


His Ile Ile Leu His Ser Met His Lys Tyr Gln Pro Arg Val His Val 
            260                 265                 270         


Ile Arg Lys Asp Cys Gly Asp Asp Leu Ser Pro Ile Lys Pro Val Pro 
        275                 280                 285             


Ser Gly Glu Gly Val Lys Ala Phe Ser Phe Pro Glu Thr Val Phe Thr 
    290                 295                 300                 


Thr Val Thr Ala Tyr Gln Asn Gln Gln Ile Thr Arg Leu Lys Ile Asp 
305                 310                 315                 320 


Arg Asn Pro Phe Ala Lys Gly Phe Arg Asp Ser Gly Arg Asn Arg Met 
                325                 330                 335     


Gly Leu Glu Ala Leu Val Glu Ser Tyr Ala Phe Trp Arg Pro Ser Leu 
            340                 345                 350         


Arg Thr Leu Thr Phe Glu Asp Ile Pro Gly Ile Pro Lys Gln Gly Asn 
        355                 360                 365             


Ala Ser Ser Ser Thr Leu Leu Gln Gly Thr Gly Asn Gly Val Pro Ala 
    370                 375                 380                 


Thr His Pro His Leu Leu Ser Gly Ser Ser Cys Ser Ser Pro Ala Phe 
385                 390                 395                 400 


His Leu Gly Pro Asn Thr Ser Gln Leu Cys Ser Leu Ala Pro Ala Asp 
                405                 410                 415     


Tyr Ser Ala Cys Ala Arg Ser Gly Leu Thr Leu Asn Arg Tyr Ser Thr 
            420                 425                 430         


Ser Leu Ala Glu Thr Tyr Asn Arg Leu Thr Asn Gln Ala Gly Glu Thr 
        435                 440                 445             


Phe Ala Pro Pro Arg Thr Pro Ser Tyr Val Gly Val Ser Ser Ser Thr 
    450                 455                 460                 


Ser Val Asn Met Ser Met Gly Gly Thr Asp Gly Asp Thr Phe Ser Cys 
465                 470                 475                 480 


Pro Gln Thr Ser Leu Ser Met Gln Ile Ser Gly Met Ser Pro Gln Leu 
                485                 490                 495     


Gln Tyr Ile Met Pro Ser Pro Ser Ser Asn Ala Phe Ala Thr Asn Gln 
            500                 505                 510         


Thr His Gln Gly Ser Tyr Asn Thr Phe Arg Leu His Ser Pro Cys Ala 
        515                 520                 525             


Leu Tyr Gly Tyr Asn Phe Ser Thr Ser Pro Lys Leu Ala Ala Ser Pro 
    530                 535                 540                 


Glu Lys Ile Val Ser Ser Gln Gly Ser Phe Leu Gly Ser Ser Pro Ser 
545                 550                 555                 560 


Gly Thr Met Thr Asp Arg Gln Met Leu Pro Pro Val Glu Gly Val His 
                565                 570                 575     


Leu Leu Ser Ser Gly Gly Gln Gln Ser Phe Phe Asp Ser Arg Thr Leu 
            580                 585                 590         


Gly Ser Leu Thr Leu Ser Ser Ser Gln Val Ser Ala His Met Val 
        595                 600                 605         


<210>  49
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Leu Leu Asp Ala Gly Pro Gln Tyr Pro Ala Ile Gly Val Thr Thr 
1               5                   10                  15      


Phe Gly Ala Ser Arg His His Ser Ala Gly Asp Val Ala Glu Arg Asp 
            20                  25                  30          


Val Gly Leu Gly Ile Asn Pro Phe Ala Asp Gly Met Gly Ala Phe Lys 
        35                  40                  45              


Leu Asn Pro Ser Ser His Glu Leu Ala Ser Ala Gly Gln Thr Ala Phe 
    50                  55                  60                  


Thr Ser Gln Ala Pro Gly Tyr Ala Ala Ala Ala Ala Leu Gly His His 
65                  70                  75                  80  


His His Pro Gly His Val Gly Ser Tyr Ser Ser Ala Ala Phe Asn Ser 
                85                  90                  95      


Thr Arg Asp Phe Leu Phe Arg Asn Arg Gly Phe Gly Asp Ala Ala Ala 
            100                 105                 110         


Ala Ala Ser Ala Gln His Ser Leu Phe Ala Ala Ser Ala Gly Gly Phe 
        115                 120                 125             


Gly Gly Pro His Gly His Thr Asp Ala Ala Gly His Leu Leu Phe Pro 
    130                 135                 140                 


Gly Leu His Glu Gln Ala Ala Gly His Ala Ser Pro Asn Val Val Asn 
145                 150                 155                 160 


Gly Gln Met Arg Leu Gly Phe Ser Gly Asp Met Tyr Pro Arg Pro Glu 
                165                 170                 175     


Gln Tyr Gly Gln Val Thr Ser Pro Arg Ser Glu His Tyr Ala Ala Pro 
            180                 185                 190         


Gln Leu His Gly Tyr Gly Pro Met Asn Val Asn Met Ala Ala His His 
        195                 200                 205             


Gly Ala Gly Ala Phe Phe Arg Tyr Met Arg Gln Pro Ile Lys Gln Glu 
    210                 215                 220                 


Leu Ile Cys Lys Trp Ile Glu Pro Glu Gln Leu Ala Asn Pro Lys Lys 
225                 230                 235                 240 


Ser Cys Asn Lys Thr Phe Ser Thr Met His Glu Leu Val Thr His Val 
                245                 250                 255     


Thr Val Glu His Val Gly Gly Pro Glu Gln Ser Asn His Ile Cys Phe 
            260                 265                 270         


Trp Glu Glu Cys Pro Arg Glu Gly Lys Pro Phe Lys Ala Lys Tyr Lys 
        275                 280                 285             


Leu Val Asn His Ile Arg Val His Thr Gly Glu Lys Pro Phe Pro Cys 
    290                 295                 300                 


Pro Phe Pro Gly Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys 
305                 310                 315                 320 


Ile His Lys Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys Glu Phe 
                325                 330                 335     


Glu Gly Cys Asp Arg Arg Phe Ala Asn Ser Ser Asp Arg Lys Lys His 
            340                 345                 350         


Met His Val His Thr Ser Asp Lys Pro Tyr Leu Cys Lys Met Cys Asp 
        355                 360                 365             


Lys Ser Tyr Thr His Pro Ser Ser Leu Arg Lys His Met Lys Val His 
    370                 375                 380                 


Glu Ser Ser Ser Gln Gly Ser Gln Pro Ser Pro Ala Ala Ser Ser Gly 
385                 390                 395                 400 


Tyr Glu Ser Ser Thr Pro Pro Thr Ile Val Ser Pro Ser Thr Asp Asn 
                405                 410                 415     


Pro Thr Thr Ser Ser Leu Ser Pro Ser Ser Ser Ala Val His His Thr 
            420                 425                 430         


Ala Gly His Ser Ala Leu Ser Ser Asn Phe Asn Glu Trp Tyr Val 
        435                 440                 445         


<210>  50
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Ala Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  51
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Met Ala Ala Asp Glu Val Ala Gly Gly Ala Arg Lys Ala Thr Lys Ser 
1               5                   10                  15      


Lys Leu Phe Glu Phe Leu Val His Gly Val Arg Pro Gly Met Pro Ser 
            20                  25                  30          


Gly Ala Arg Met Pro His Gln Gly Ala Pro Met Gly Pro Pro Gly Ser 
        35                  40                  45              


Pro Tyr Met Gly Ser Pro Ala Val Arg Pro Gly Leu Ala Pro Ala Gly 
    50                  55                  60                  


Met Glu Pro Ala Arg Lys Arg Ala Ala Pro Pro Pro Gly Gln Ser Gln 
65                  70                  75                  80  


Ala Gln Ser Gln Gly Gln Pro Val Pro Thr Ala Pro Ala Arg Ser Arg 
                85                  90                  95      


Ser Ala Lys Arg Arg Lys Met Ala Asp Lys Ile Leu Pro Gln Arg Ile 
            100                 105                 110         


Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe 
        115                 120                 125             


Glu Arg Lys Leu Asp Gln Thr Ile Met Arg Lys Arg Val Asp Ile Gln 
    130                 135                 140                 


Glu Ala Leu Lys Arg Pro Met Lys Gln Lys Arg Lys Leu Arg Leu Tyr 
145                 150                 155                 160 


Ile Ser Asn Thr Phe Asn Pro Ala Lys Pro Asp Ala Glu Asp Ser Asp 
                165                 170                 175     


Gly Ser Ile Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
            180                 185                 190         


Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
        195                 200                 205             


Val Ile Glu Leu Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val 
    210                 215                 220                 


Glu Trp His Arg Thr Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
225                 230                 235                 240 


Lys Arg Pro Gly Asp Leu Ser Val Arg Cys Thr Leu Leu Leu Met Leu 
                245                 250                 255     


Asp Tyr Gln Pro Pro Gln Phe Lys Leu Asp Pro Arg Ala Ala Arg Ala 
            260                 265                 270         


Ala Gly Leu His Thr Gln Ser Arg Ser Ala Ile Val Gln Ala Leu Trp 
        275                 280                 285             


Gln Tyr Val Lys Thr Asn Arg Leu Gln Asp Ser His Asp Lys Glu Tyr 
    290                 295                 300                 


Ile Asn Gly Asp Lys Tyr Phe Gln Gln Ile Phe Asp Cys Pro Arg Leu 
305                 310                 315                 320 


Lys Phe Ser Glu Ile Pro Gln Arg Leu Thr Ala Leu Leu Leu Pro Pro 
                325                 330                 335     


Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Ser Asp Gln 
            340                 345                 350         


Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Glu Glu Pro Leu 
        355                 360                 365             


Lys Gly Gln Met Ser Ser Phe Leu Leu Ser Thr Ala Asn Gln Gln Glu 
    370                 375                 380                 


Ile Ser Ala Leu Asp Ser Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
385                 390                 395                 400 


Gln Leu Lys Ile Gln Arg Asp Phe Met Leu Ser Phe Ser Arg Asp Pro 
                405                 410                 415     


Lys Gly Tyr Val Gln Asp Leu Leu Arg Ser Gln Ser Arg Asp Leu Lys 
            420                 425                 430         


Val Met Thr Asp Val Ala Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu 
        435                 440                 445             


Phe Tyr His Gln Pro Trp Ser Gln Glu Ala Val Ser Arg Tyr Phe Tyr 
    450                 455                 460                 


Cys Lys Ile Gln Gln Arg Arg Gln Glu Leu Glu Gln Ser Leu Val Val 
465                 470                 475                 480 


Arg Asn Thr 
            


<210>  52
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
145                 150                 155                 160 


His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His 
                165                 170                 175     


Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
            180                 185                 190         


Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
        195                 200                 205             


Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
    210                 215                 220                 


Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                245                 250                 255     


Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
            260                 265                 270         


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
        275                 280                 285             


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
    290                 295                 300                 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
305                 310                 315                 320 


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                325                 330                 335     


Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
            340                 345                 350         


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
        355                 360                 365             


Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
    370                 375                 380                 


Thr Ser Ala Ala Asp Ser Ala Gln Leu Glu Lys Glu Val Val Arg Val 
385                 390                 395                 400 


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                405                 410                 415     


Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
            420                 425                 430         


Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440             


<210>  53
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Thr Ala Ala Ser Asn Pro Tyr Ser Ile Leu Ser Ser Thr Ser 
1               5                   10                  15      


Leu Val His Ala Asp Ser Ala Gly Met Gln Gln Gly Ser Pro Phe Arg 
            20                  25                  30          


Asn Pro Gln Lys Leu Leu Gln Ser Asp Tyr Leu Gln Gly Val Pro Ser 
        35                  40                  45              


Asn Gly His Pro Leu Gly His His Trp Val Thr Ser Leu Ser Asp Gly 
    50                  55                  60                  


Gly Pro Trp Ser Ser Thr Leu Ala Thr Ser Pro Leu Asp Gln Gln Asp 
65                  70                  75                  80  


Val Lys Pro Gly Arg Glu Asp Leu Gln Leu Gly Ala Ile Ile His His 
                85                  90                  95      


Arg Ser Pro His Val Ala His His Ser Pro His Thr Asn His Pro Asn 
            100                 105                 110         


Ala Trp Gly Ala Ser Pro Ala Pro Asn Pro Ser Ile Thr Ser Ser Gly 
        115                 120                 125             


Gln Pro Leu Asn Val Tyr Ser Gln Pro Gly Phe Thr Val Ser Gly Met 
    130                 135                 140                 


Leu Glu His Gly Gly Leu Thr Pro Pro Pro Ala Ala Ala Ser Ala Gln 
145                 150                 155                 160 


Ser Leu His Pro Val Leu Arg Glu Pro Pro Asp His Gly Glu Leu Gly 
                165                 170                 175     


Ser His His Cys Gln Asp His Ser Asp Glu Glu Thr Pro Thr Ser Asp 
            180                 185                 190         


Glu Leu Glu Gln Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu 
        195                 200                 205             


Gly Phe Thr Gln Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly 
    210                 215                 220                 


Asn Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
225                 230                 235                 240 


Ser Phe Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu 
                245                 250                 255     


Glu Glu Ala Asp Ser Ser Thr Gly Ser Pro Thr Ser Ile Asp Lys Ile 
            260                 265                 270         


Ala Ala Gln Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser 
        275                 280                 285             


Val Lys Gly Val Leu Glu Thr His Phe Leu Lys Cys Pro Lys Pro Ala 
    290                 295                 300                 


Ala Gln Glu Ile Ser Ser Ala Ala Asp Ser Ala Gln Leu Glu Lys Glu 
305                 310                 315                 320 


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met 
                325                 330                 335     


Thr Pro Pro Gly Asp Gln Gln Pro His Glu Val Tyr Ser His Thr Val 
            340                 345                 350         


Lys Thr Asp Thr Ser Cys His Asp Leu 
        355                 360     


<210>  54
<211>  1954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Arg Gly Pro Val Gly Thr Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Thr Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Thr Val Thr Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Thr Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Thr Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Thr Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Thr Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Thr Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Thr Pro Ile Val Asp Pro Thr Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Thr Gly Gly Thr Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp 
705                 710                 715                 720 


Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Gln Thr Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Thr Tyr Thr Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Thr Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Thr 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Thr  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Thr  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Thr  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Thr Ala Asp 
    1100                 1105                 1110             


Thr Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Asn  Lys Lys Val 
    1130                 1135                 1140             


Met Ile  Tyr Arg Phe Val Thr  Arg Ala Ser Val Glu  Glu Arg Ile 
    1145                 1150                 1155             


Thr Gln  Val Ala Lys Arg Lys  Met Met Leu Thr His  Leu Val Val 
    1160                 1165                 1170             


Arg Pro  Gly Leu Gly Ser Lys  Ser Gly Ser Met Thr  Lys Gln Glu 
    1175                 1180                 1185             


Leu Asp  Asp Ile Leu Lys Phe  Gly Thr Glu Glu Leu  Phe Lys Asp 
    1190                 1195                 1200             


Asp Val  Glu Gly Met Met Ser  Gln Gly Gln Arg Pro  Val Thr Pro 
    1205                 1210                 1215             


Ile Pro  Asp Val Gln Ser Ser  Lys Gly Gly Asn Leu  Ala Ala Ser 
    1220                 1225                 1230             


Ala Lys  Lys Lys His Gly Ser  Thr Pro Pro Gly Asp  Asn Lys Asp 
    1235                 1240                 1245             


Val Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Ala  Ala Ile Ser 
    1250                 1255                 1260             


Lys Leu  Leu Asp Arg Asn Gln  Asp Ala Thr Asp Asp  Thr Glu Leu 
    1265                 1270                 1275             


Gln Asn  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1280                 1285                 1290             


Val Val  Arg Glu Glu Asp Gly  Val Glu Glu Val Glu  Arg Glu Ile 
    1295                 1300                 1305             


Ile Lys  Gln Glu Glu Asn Val  Asp Pro Asp Tyr Trp  Glu Lys Leu 
    1310                 1315                 1320             


Leu Arg  His His Tyr Glu Gln  Gln Gln Glu Asp Leu  Ala Arg Asn 
    1325                 1330                 1335             


Leu Gly  Lys Gly Lys Arg Ile  Arg Lys Gln Val Asn  Tyr Asn Asp 
    1340                 1345                 1350             


Ala Ser  Gln Glu Asp Gln Glu  Trp Gln Asp Glu Leu  Ser Asp Asn 
    1355                 1360                 1365             


Gln Ser  Glu Tyr Ser Ile Gly  Ser Glu Asp Glu Asp  Glu Asp Phe 
    1370                 1375                 1380             


Glu Glu  Arg Pro Glu Gly Gln  Ser Gly Arg Arg Gln  Ser Arg Arg 
    1385                 1390                 1395             


Gln Leu  Lys Ser Asp Arg Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1400                 1405                 1410             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1415                 1420                 1425             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Trp Gly  Met Pro Pro 
    1430                 1435                 1440             


Gln Asp  Ala Phe Asn Ser His  Trp Leu Val Arg Asp  Leu Arg Gly 
    1445                 1450                 1455             


Lys Ser  Glu Lys Glu Phe Arg  Ala Tyr Val Ser Leu  Phe Met Arg 
    1460                 1465                 1470             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Thr  Phe Ala Asp 
    1475                 1480                 1485             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Thr Arg 
    1490                 1495                 1500             


Ile Gly  Val Met Ser Leu Val  Arg Lys Lys Val Gln  Glu Phe Glu 
    1505                 1510                 1515             


His Val  Asn Gly Lys Tyr Ser  Thr Pro Asp Leu Ile  Pro Glu Gly 
    1520                 1525                 1530             


Pro Glu  Gly Lys Lys Ser Gly  Glu Val Ile Ser Ser  Asp Pro Asn 
    1535                 1540                 1545             


Thr Pro  Val Pro Ala Ser Pro  Ala His Leu Leu Pro  Ala Pro Leu 
    1550                 1555                 1560             


Gly Leu  Pro Asp Lys Met Glu  Ala Gln Leu Gly Tyr  Met Asp Glu 
    1565                 1570                 1575             


Lys Asp  Pro Gly Ala Gln Lys  Pro Arg Gln Pro Leu  Glu Val Gln 
    1580                 1585                 1590             


Ala Leu  Pro Ala Ala Leu Asp  Arg Val Glu Ser Glu  Asp Lys His 
    1595                 1600                 1605             


Glu Ser  Pro Ala Ser Lys Glu  Arg Ala Arg Glu Glu  Arg Pro Glu 
    1610                 1615                 1620             


Glu Thr  Glu Lys Ala Pro Pro  Ser Pro Glu Gln Leu  Pro Arg Glu 
    1625                 1630                 1635             


Glu Val  Leu Pro Glu Lys Glu  Lys Ile Leu Asp Lys  Leu Glu Leu 
    1640                 1645                 1650             


Ser Leu  Ile His Ser Arg Gly  Asp Ser Ser Glu Leu  Arg Pro Asp 
    1655                 1660                 1665             


Asp Thr  Lys Ala Glu Glu Lys  Glu Pro Ile Glu Thr  Gln Gln Asn 
    1670                 1675                 1680             


Gly Asp  Lys Glu Glu Asp Asp  Glu Gly Lys Lys Glu  Asp Lys Lys 
    1685                 1690                 1695             


Gly Lys  Phe Lys Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Thr 
    1700                 1705                 1710             


Glu Leu  His Thr Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Val Ser 
    1715                 1720                 1725             


Ser Gly  Lys Ile Tyr Asp Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1730                 1735                 1740             


Leu Leu  Ala Gly Ile Val Thr  His Gly Tyr Ala Arg  Trp Gln Asp 
    1745                 1750                 1755             


Ile Gln  Asn Asp Pro Arg Tyr  Met Ile Leu Asn Glu  Pro Phe Lys 
    1760                 1765                 1770             


Ser Glu  Val His Lys Gly Asn  Tyr Leu Glu Met Lys  Asn Lys Phe 
    1775                 1780                 1785             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1790                 1795                 1800             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Met Thr  Gln Asp Pro 
    1805                 1810                 1815             


Asn His  Pro Ala Met Ala Leu  Asn Ala Arg Leu Ala  Glu Val Glu 
    1820                 1825                 1830             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1835                 1840                 1845             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1850                 1855                 1860             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Thr Arg Leu 
    1865                 1870                 1875             


Pro Ser  Met Leu Ser Arg Ile  Pro Pro Val Ala Ala  Arg Leu Gln 
    1880                 1885                 1890             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Thr Asn  Arg Ala Gly 
    1895                 1900                 1905             


Asp Pro  Thr Ile Gln Gln Gly  Ala Phe Gly Ser Ser  Gln Met Tyr 
    1910                 1915                 1920             


Ser Asn  Asn Phe Gly Pro Asn  Phe Arg Gly Pro Gly  Pro Gly Gly 
    1925                 1930                 1935             


Ile Val  Asn Tyr Asn Gln Met  Pro Leu Gly Pro Tyr  Val Thr Asp 
    1940                 1945                 1950             


Ile 
    


<210>  55
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Ala Lys His Lys Ala Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  56
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Thr Met Thr Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly 
1               5                   10                  15      


Lys Ala Val Phe Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro 
            20                  25                  30          


Ser Pro Met Ser His Gly His Tyr Ser Met His Cys Leu His Ser Ala 
        35                  40                  45              


Gly His Ser Gln Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser 
    50                  55                  60                  


Arg Pro Leu Gly Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser 
65                  70                  75                  80  


Ser Pro Tyr Ile Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu 
                85                  90                  95      


Ala Gln Ser Arg Leu Glu Asp Pro Gly Ala Asp Ser Glu Lys Ser Thr 
            100                 105                 110         


Val Val Glu Gly Gly Glu Val Arg Phe Asn Gly Lys Gly Lys Lys Ile 
        115                 120                 125             


Arg Lys Pro Arg Thr Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn 
    130                 135                 140                 


Arg Arg Phe Gln Gln Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu 
145                 150                 155                 160 


Ala Ala Ala Ser Ala Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn Lys Arg Ser Lys Phe Lys Lys Leu Met Lys Gln Gly Gly Ala 
            180                 185                 190         


Ala Leu Glu Gly Ser Ala Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly 
        195                 200                 205             


Ser Pro Pro Val Pro Pro Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys 
    210                 215                 220                 


Gly Ser Gly Gly Asn Ala Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Trp 
225                 230                 235                 240 


Tyr Pro Ser Ala His Gln Glu Ala Met Gln Gln Pro Gln Leu Met 
                245                 250                 255 


<210>  57
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Ala Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His 
        35                  40                  45              


Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser 
    50                  55                  60                  


Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly 
                85                  90                  95      


Leu Asn Asn Val Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr 
            100                 105                 110         


Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro 
        115                 120                 125             


Ala Asn Asn Glu Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile 
    130                 135                 140                 


Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr 
                165                 170                 175     


Leu Ala Leu Pro Glu Arg Ala Glu Ala Ala Ala Ser Ala Gly Leu Thr 
            180                 185                 190         


Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys 
        195                 200                 205             


Lys Met Trp Lys Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala 
    210                 215                 220                 


Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser 
225                 230                 235                 240 


Trp Asp Phe Gly Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala 
            260                 265                 270         


Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly 
        275                 280                 285             


Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln 
    290                 295                 300                 


Thr Pro Gln Pro His His His His His His His Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Pro Val Ser Ala Gly Thr Ile Phe 
                325             


<210>  58
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Ala Gln Val 
    50                  55                  60                  


Ala Arg Gln Ala Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  59
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Ala Ser Thr Ala Glu 
        35                  40                  45              


Ala Leu His Leu Gln Gln Gln Gln Ala Ala Gln Ala Ala Arg Gln Ala 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu His Met Gln 
    210                 215                 220                 


Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu 
225                 230                 235                 240 


Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu Pro 
                245                 250                 255     


Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu Val 
            260                 265                 270         


Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly Leu 
        275                 280                 285             


Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser 
    290                 295                 300                 


Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln Ser 
305                 310                 315                 320 


Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr Gly 
                325                 330                 335     


Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys 
            340                 345                 350         


Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn Asn 
        355                 360                 365             


Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met 
    370                 375                 380                 


Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg 
385                 390                 395                 400 


Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro Lys 
                405                 410                 415     


Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser Lys 
            420                 425                 430         


Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr 
        435                 440                 445             


Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr 
    450                 455                 460                 


Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp 
465                 470                 475                 480 


Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe 
                485                 490                 495     


Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile 
            500                 505                 510         


Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu 
        515                 520                 525             


Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala 
    530                 535                 540                 


Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys 
545                 550                 555                 560 


Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu 
                565                 570                 575     


Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr 
            580                 585                 590         


Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn 
        595                 600                 605             


Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser 
    610                 615                 620                 


Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val 
625                 630                 635                 640 


His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn 
                645                 650                 655     


Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His Val 
            660                 665                 670         


Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu 
        675                 680                 685             


Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile 
    690                 695                 700                 


Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 


<210>  60
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Arg Ser Val Asp Arg Ala Gly Lys Asp Pro Arg Pro 
            180                 185                 190         


Pro Ile Pro Ser Pro Asp Thr Leu Cys Pro Pro Ser Thr Leu Ser Ala 
        195                 200                 205             


Val Pro Gln Ser Ser Tyr Pro Leu Leu Ala Asn Gly Val Cys Lys Trp 
    210                 215                 220                 


Pro Gly Cys Glu Lys Val Phe Glu Glu Pro Glu Asp Phe Leu Lys His 
225                 230                 235                 240 


Cys Gln Ala Asp His Leu Leu Asp Glu Lys Gly Arg Ala Gln Cys Leu 
                245                 250                 255     


Leu Gln Arg Glu Met Val Gln Ser Ala Glu Gln Gln Ala Val Ala Glu 
            260                 265                 270         


Lys Glu Lys Leu Ser Ala Met Gln Ala His Leu Ala Gly Lys Met Ala 
        275                 280                 285             


Leu Thr Lys Ala Ser Ser Val Ala Ser Ser Asp Lys Gly Ser Cys Cys 
    290                 295                 300                 


Ile Val Ala Ala Gly Ser Gln Gly Pro Val Val Pro Ala Trp Ser Gly 
305                 310                 315                 320 


Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala Val Arg Arg His Leu Trp 
                325                 330                 335     


Gly Ser His Gly Asn Ser Thr Phe Pro Glu Phe Leu His Asn Met Asp 
            340                 345                 350         


Tyr Phe Lys Phe His Asn Met Arg Pro Pro Phe Thr Tyr Ala Thr Leu 
        355                 360                 365             


Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln Arg Thr Leu Asn 
    370                 375                 380                 


Glu Ile Tyr His Trp Phe Thr Arg Met Phe Ala Phe Phe Arg Asn His 
385                 390                 395                 400 


Pro Ala Thr Trp Lys Asn Ala Ile Arg His Asn Leu Ser Leu His Lys 
                405                 410                 415     


Cys Phe Val Arg Val Glu Ser Glu Lys Gly Ala Val Trp Thr Val Asp 
            420                 425                 430         


Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro Ser Arg Cys Ser 
        435                 440                 445             


Asn Pro Thr Pro Gly Pro 
    450                 


<210>  61
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Ala Pro Ser Ser Ala 
        35                  40                  45              


Ala Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Val Asp Met 
        195                 200                 205             


Phe Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met 
    210                 215                 220                 


Ser Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn 
225                 230                 235                 240 


Ala Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile 
                245                 250                 255     


Lys Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys 
            260                 265                 270         


Ala Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu 
        275                 280                 285             


Gly Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly 
    290                 295                 300                 


Val Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys 
305                 310                 315                 320 


Arg Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser 
                325                 330                 335     


Gly Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser 
            340                 345                 350         


Asn Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu 
        355                 360                 365             


Pro Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr 
    370                 375                 380                 


Phe Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val 
385                 390                 395                 400 


Leu Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser 
                405                 410                 415     


Gln Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val 
            420                 425                 430         


Leu Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440             


<210>  62
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Met Asn Leu Val Gly Ser Tyr Ala His His His His His His His Pro 
1               5                   10                  15      


His Pro Ala His Pro Met Leu His Glu Pro Phe Leu Phe Gly Pro Ala 
            20                  25                  30          


Ser Arg Cys His Gln Glu Arg Pro Tyr Phe Gln Ser Trp Leu Leu Ser 
        35                  40                  45              


Pro Ala Asp Ala Ala Pro Asp Phe Pro Ala Gly Gly Pro Pro Pro Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Thr Ala Tyr Gly Pro Asp Ala Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Gly Arg Leu Glu Ala Leu Gly Gly Arg Leu Gly Arg Arg Lys 
                85                  90                  95      


Gly Ser Gly Pro Lys Lys Glu Arg Arg Arg Thr Glu Ser Ile Asn Ser 
            100                 105                 110         


Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr 
        115                 120                 125             


Lys Ala Ser Lys Ala Lys Thr Ala Arg Leu Ala Thr Ser Tyr Ile Ala 
    130                 135                 140                 


Tyr Leu Met Asp Val Leu Ala Lys Asp Ala Gln Ser Gly Asp Pro Glu 
145                 150                 155                 160 


Ala Phe Lys Ala Glu Leu Lys Lys Ala Asp Gly Gly Arg Glu Ser Lys 
                165                 170                 175     


Arg Lys Arg Glu Leu Gln Gln His Glu Gly Phe Pro Pro Ala Leu Gly 
            180                 185                 190         


Pro Val Glu Lys Arg Ile Lys Gly Arg Thr Gly Trp Pro Gln Gln Val 
        195                 200                 205             


Trp Ala Leu Glu Leu Asn Gln 
    210                 215 


<210>  63
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Met Pro Ala Asp Ile Met Glu Lys Asn Ser Ser Ser Pro Val Ala Ala 
1               5                   10                  15      


Thr Pro Ala Ser Val Asn Thr Thr Pro Asp Lys Pro Lys Thr Ala Ser 
            20                  25                  30          


Glu His Arg Lys Ser Ser Lys Pro Ile Met Glu Lys Arg Arg Arg Ala 
        35                  40                  45              


Arg Ile Asn Glu Ser Ala Ser Gln Ala Lys Thr Ala Ile Leu Asp Ala 
    50                  55                  60                  


Leu Lys Lys Asp Ser Ser Arg His Ser Lys Leu Glu Lys Ala Asp Ile 
65                  70                  75                  80  


Leu Glu Met Thr Val Lys His Leu Arg Asn Leu Gln Arg Ala Gln Met 
                85                  90                  95      


Thr Ala Ala Leu Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr Arg Ala 
            100                 105                 110         


Gly Phe Ser Glu Cys Met Asn Glu Val Thr Arg Phe Leu Ser Thr Cys 
        115                 120                 125             


Glu Gly Val Asn Thr Glu Val Arg Thr Arg Leu Leu Gly His Leu Ala 
    130                 135                 140                 


Asn Cys Met Thr Gln Ile Asn Ala Met Thr Tyr Pro Gly Gln Pro His 
145                 150                 155                 160 


Pro Ala Leu Gln Ala Pro Pro Pro Pro Pro Pro Gly Pro Gly Gly Pro 
                165                 170                 175     


Gln His Ala Pro Phe Ala Pro Pro Pro Pro Leu Val Pro Ile Pro Gly 
            180                 185                 190         


Gly Ala Ala Pro Pro Pro Gly Gly Ala Pro Cys Lys Leu Gly Ser Gln 
        195                 200                 205             


Ala Gly Glu Ala Ala Lys Val Phe Gly Gly Phe Gln Val Val Pro Ala 
    210                 215                 220                 


Pro Asp Gly Gln Phe Ala Phe Leu Ile Pro Asn Gly Ala Phe Ala His 
225                 230                 235                 240 


Ser Gly Pro Val Ile Pro Val Tyr Thr Ser Asn Ser Gly Thr Ser Val 
                245                 250                 255     


Gly Pro Asn Ala Val Ser Pro Ser Ser Gly Pro Ser Leu Thr Ala Asp 
            260                 265                 270         


Ser Met Trp Arg Pro Trp Arg Asn 
        275                 280 


<210>  64
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Met Ala Pro Ser Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys 
1               5                   10                  15      


Asn Arg Leu Arg Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile 
            20                  25                  30          


Asn Ser Ser Ala Glu Gln Ala Lys Ala Leu Leu Glu Gln Glu Phe Ala 
        35                  40                  45              


Arg His Gln Pro Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met 
    50                  55                  60                  


Ala Val Ser Tyr Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Lys Ser Leu His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu 
                85                  90                  95      


Gln Glu Ala Val Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln 
            100                 105                 110         


Met Lys Leu Leu Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Lys Glu Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu 
    130                 135                 140                 


Ser Ala Lys Ala Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Trp Arg Pro Trp 
                165     


<210>  65
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Ala Leu Ser Asp Ala Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


<210>  66
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Met Leu Phe His Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp 
1               5                   10                  15      


Glu Met Asp Arg Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala 
            20                  25                  30          


Ile Asp Arg Gly Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp 
        35                  40                  45              


Arg Ala Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr 
    50                  55                  60                  


Tyr Leu Leu Ala Val Asp Lys Gln Trp His Ala Arg Cys Ala Lys Cys 
65                  70                  75                  80  


Cys Glu Cys Lys Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys 
                85                  90                  95      


Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val 
            100                 105                 110         


Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val 
        115                 120                 125             


Met Arg Ala Arg Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr 
    130                 135                 140                 


Thr Cys Asn Lys Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp 
145                 150                 155                 160 


Ser Leu Val Tyr Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu 
                165                 170                 175     


Tyr Pro Ala His Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro 
        195                 200                 205             


Leu Gly Leu Pro Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg 
    210                 215                 220                 


Pro Arg Lys Arg Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr 
225                 230                 235                 240 


Asn Ala Ala Leu Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg 
                245                 250                 255     


Asp Gln Pro Tyr Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser 
            260                 265                 270         


Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn 
        275                 280                 285             


His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly 
    290                 295                 300                 


Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys 
305                 310                 315                 320 


Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser 
                325                 330                 335     


Thr Asp Ala Ala Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu 
            340                 345                 350         


Leu Ser Asn Ala Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr 
        355                 360                 365             


Asp Leu Thr Ser Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser 
    370                 375                 380                 


Val Pro Gly Asn Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr 
385                 390                 395                 400 


Thr Leu Thr Asn Leu Phe 
                405     


<210>  67
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Ala Ala Asp Leu Asp Ala Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  68
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Ala Glu Gln Ala Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210>  69
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Ala Ser Val Ala Cys Asp Cys Glu Ala Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  70
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Met Ala Gln Pro Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser 
1               5                   10                  15      


Ala Ala Trp Gly Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys 
            20                  25                  30          


Gly Arg Ser Leu Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala 
        35                  40                  45              


Asp Ser Pro Val Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro 
    50                  55                  60                  


Arg Ala Pro Ser Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly 
65                  70                  75                  80  


Ser Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg 
                85                  90                  95      


Thr Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser 
            100                 105                 110         


Val Ala Pro Ala Gly Gln Ser Leu Thr Lys Ala Glu Thr Ala Arg Leu 
        115                 120                 125             


Ala Ile Arg Tyr Ala Gly His Ala Ser Ala Val Leu Gly Leu Ser Glu 
    130                 135                 140                 


Glu Ser Leu Gln Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro 
145                 150                 155                 160 


Arg Gly Cys Pro Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr 
                165                 170                 175     


Arg Thr Gln Ala Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val 
            180                 185                 190         


Ser Ala Val Arg Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro 
        195                 200                 205             


Gly Ala Arg Ala Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala 
    210                 215                 220                 


Glu Ala Ala Cys Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser 
225                 230                 235                 240 


Pro Leu Leu Pro Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro 
                245                 250                 255     


Leu Ser Pro Leu Glu Trp Leu Pro Glu Glu Pro Lys 
            260                 265             


<210>  71
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met Glu Ala Ala Ser Pro Pro Ala Arg Asp Val Asp Leu Thr Ala Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
    50                  55                  60                  


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
            180                 185                 190         


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
        195                 200                 205             


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
    210                 215                 220                 


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
225                 230                 235                 240 


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
                245                 250                 255     


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
            260                 265                 270         


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
        275                 280                 285             


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
    290                 295                 300                 


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
305                 310                 315                 320 


<210>  72
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly 
1               5                   10                  15      


Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro 
            20                  25                  30          


Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg 
        35                  40                  45              


His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln 
    50                  55                  60                  


Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 
65                  70                  75                  80  


Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr 
                85                  90                  95      


Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu 
            100                 105                 110         


Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp 
        115                 120                 125             


Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu 
    130                 135                 140                 


Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His 
                165                 170                 175     


Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp 
            180                 185                 190         


Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu 
        195                 200                 205             


Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu 
    210                 215                 220                 


Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn 
225                 230                 235                 240 


Glu Asn Leu Gly Arg Lys Ser Glu Ala Ser Ala Asp Leu Asp Ser Asp 
                245                 250                 255     


Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His 
            260                 265                 270         


Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser 
        275                 280                 285             


Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys 
    290                 295                 300                 


Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu 
305                 310                 315                 320 


Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp 
                325                 330                 335     


Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln 
            340                 345                 350         


Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro 
        355                 360                 365             


Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg 
    370                 375                 380                 


Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala 
385                 390                 395                 400 


Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn 
                405                 410                 415     


Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr 
            420                 425                 430         


Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met 
        435                 440                 445             


Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser 
    450                 455                 460                 


Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro 
465                 470                 475                 480 


Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg 
                485                 490                 495     


Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr 
            500                 505                 510         


Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys 
        515                 520                 525             


Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser 
    530                 535                 540                 


Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn 
545                 550                 555                 560 


Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala 
                565                 570                 575     


Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val 
            580                 585                 590         


Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe 
        595                 600                 605             


Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro 
    610                 615                 620                 


Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser 
625                 630                 635                 640 


Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys 
                645                 650                 655     


Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly 
            660                 665                 670         


Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser 
        675                 680                 685             


Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly 
    690                 695                 700                 


Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr 
705                 710                 715                 720 


Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn 
                725                 730                 735     


Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro 
            740                 745                 750         


Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp Glu Asn 
        755                 760                 765             


Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys 
    770                 775                 780                 


Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala 
785                 790                 795                 800 


Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys Trp Asp 
                805                 810                 815     


Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp Glu Asp 
            820                 825                 830         


Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala 
        835                 840                 845             


Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys 
    850                 855                 860                 


Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu 
865                 870                 875                 880 


Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr 
                885                 890                 895     


Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly 
            900                 905                 910         


His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro 
        915                 920                 925             


Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys 
    930                 935                 940                 


Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln 
945                 950                 955                 960 


Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys 
                965                 970                 975     


Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln 
            980                 985                 990         


Phe Ser Trp Lys Ser Val Lys Thr  Glu Gly Met Ser Cys  Pro Thr Pro 
        995                 1000                 1005             


Gly Cys  Asp Gly Ser Gly His  Val Ser Gly Ser Phe  Leu Thr His 
    1010                 1015                 1020             


Arg Ser  Leu Ser Gly Cys Pro  Arg Ala Thr Ser Ala  Met Lys Lys 
    1025                 1030                 1035             


Ala Lys  Leu Ser Gly Glu Gln  Met Leu Thr Ile Lys  Gln Arg Ala 
    1040                 1045                 1050             


Ser Asn  Gly Ile Glu Asn Asp  Glu Glu Ile Lys Gln  Leu Asp Glu 
    1055                 1060                 1065             


Glu Ile  Lys Glu Leu Asn Glu  Ser Asn Ser Gln Met  Glu Ala Asp 
    1070                 1075                 1080             


Met Ile  Lys Leu Arg Thr Gln  Ile Thr Thr Met Glu  Ser Asn Leu 
    1085                 1090                 1095             


Lys Thr  Ile Glu Glu Glu Asn  Lys Val Ile Glu Gln  Gln Asn Glu 
    1100                 1105                 1110             


Ser Leu  Leu His Glu Leu Ala  Asn Leu Ser Gln Ser  Leu Ile His 
    1115                 1120                 1125             


Ser Leu  Ala Asn Ile Gln Leu  Pro His Met Asp Pro  Ile Asn Glu 
    1130                 1135                 1140             


Gln Asn  Phe Asp Ala Tyr Val  Thr Thr Leu Thr Glu  Met Tyr Thr 
    1145                 1150                 1155             


Asn Gln  Asp Arg Tyr Gln Ser  Pro Glu Asn Lys Ala  Leu Leu Glu 
    1160                 1165                 1170             


Asn Ile  Lys Gln Ala Val Arg  Gly Ile Gln Val 
    1175                 1180                 


<210>  73
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Ala Gln Glu Ala 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  74
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Met Ala Glu Ser Glu Asn Arg Lys Glu Leu Ser Glu Ser Ser Gln Glu 
1               5                   10                  15      


Glu Ala Gly Asn Gln Ile Met Val Glu Gly Leu Gly Glu His Leu Glu 
            20                  25                  30          


Arg Gly Glu Asp Ala Ala Ala Gly Leu Gly Asp Asp Gly Lys Cys Gly 
        35                  40                  45              


Glu Glu Ala Ala Ala Gly Leu Gly Glu Glu Gly Glu Asn Gly Glu Asp 
    50                  55                  60                  


Thr Ala Ala Gly Ser Gly Glu Asp Gly Lys Lys Gly Gly Asp Thr Asp 
65                  70                  75                  80  


Glu Asp Ser Glu Ala Asp Arg Pro Lys Gly Leu Ile Gly Tyr Val Leu 
                85                  90                  95      


Asp Thr Asp Phe Val Glu Ser Leu Pro Val Lys Val Lys Tyr Arg Val 
            100                 105                 110         


Leu Ala Leu Lys Lys Leu Gln Thr Arg Ala Ala Asn Leu Glu Ser Lys 
        115                 120                 125             


Phe Leu Arg Glu Phe His Asp Ile Glu Arg Lys Phe Ala Glu Met Tyr 
    130                 135                 140                 


Gln Pro Leu Leu Glu Lys Arg Arg Gln Ile Ile Asn Ala Ile Tyr Glu 
145                 150                 155                 160 


Pro Thr Glu Glu Glu Cys Glu Tyr Lys Ser Asp Ser Glu Asp Cys Asp 
                165                 170                 175     


Asp Glu Glu Met Cys His Glu Glu Met Tyr Gly Asn Glu Glu Gly Met 
            180                 185                 190         


Val His Glu Tyr Val Asp Glu Asp Asp Gly Tyr Glu Asp Tyr Tyr Tyr 
        195                 200                 205             


Asp Tyr Ala Val Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ile 
    210                 215                 220                 


Glu Ala Thr Gly Glu Glu Asn Lys Glu Glu Glu Asp Pro Lys Gly Ile 
225                 230                 235                 240 


Pro Asp Phe Trp Leu Thr Val Leu Lys Asn Val Asp Thr Leu Thr Pro 
                245                 250                 255     


Leu Ile Lys Lys Tyr Asp Glu Pro Ile Leu Lys Ala Leu Thr Asp Ala 
            260                 265                 270         


Lys Val Lys Leu Ser Asp Pro Gly Glu Pro Leu Ser Phe Thr Leu Glu 
        275                 280                 285             


Phe His Phe Lys Pro Asn Glu Tyr Phe Lys Asn Glu Leu Leu Thr Lys 
    290                 295                 300                 


Thr Tyr Val Leu Lys Ser Lys Leu Ala Tyr Tyr Asp Pro His Pro Tyr 
305                 310                 315                 320 


Arg Gly Thr Ala Ile Glu Tyr Ser Thr Gly Cys Glu Ile Asp Trp Asn 
                325                 330                 335     


Glu Gly Lys Asn Val Thr Leu Lys Thr Ile Lys Lys Lys Gln Lys His 
            340                 345                 350         


Arg Ile Trp Gly Thr Ile Arg Thr Val Thr Glu Asp Phe Pro Lys Asp 
        355                 360                 365             


Ser Phe Phe Asn Phe Phe Ser Pro His Gly Ile Thr Ser Asn Gly Arg 
    370                 375                 380                 


Asp Gly Asn Asp Asp Phe Leu Leu Gly His Asn Leu Arg Thr Tyr Ile 
385                 390                 395                 400 


Ile Pro Arg Ser Val Leu Phe Phe Ser Gly Asp Ala Leu Glu Ser Gln 
                405                 410                 415     


Gln Glu Gly Val Val Arg Glu Val Asn Asp Ala Ile Tyr Asp Lys Ile 
            420                 425                 430         


Ile Tyr Asp Asn Trp Met Ala Ala Ile Glu Glu Val Lys Ala Cys Cys 
        435                 440                 445             


Lys Asn Leu Glu Ala Leu Val Glu Asp Ile Asp Arg 
    450                 455                 460 


<210>  75
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Ala Ser Lys Ala Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  76
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Met Leu Thr Arg Leu Phe Ser Glu Pro Gly Leu Leu Ser Asp Val Pro 
1               5                   10                  15      


Lys Phe Ala Ser Trp Gly Asp Gly Glu Asp Asp Glu Pro Arg Ser Asp 
            20                  25                  30          


Lys Gly Asp Ala Pro Pro Pro Pro Pro Pro Ala Pro Gly Pro Gly Ala 
        35                  40                  45              


Pro Gly Pro Ala Arg Ala Ala Lys Pro Val Pro Leu Arg Gly Glu Glu 
    50                  55                  60                  


Gly Thr Glu Ala Thr Leu Ala Glu Val Lys Glu Glu Gly Glu Leu Gly 
65                  70                  75                  80  


Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Leu Asp Glu Ala 
                85                  90                  95      


Glu Gly Glu Arg Pro Lys Lys Arg Gly Pro Lys Lys Arg Lys Met Thr 
            100                 105                 110         


Lys Ala Arg Leu Glu Arg Ser Lys Leu Arg Arg Gln Lys Ala Asn Ala 
        115                 120                 125             


Arg Glu Arg Asn Arg Met His Asp Leu Asn Ala Ala Leu Asp Asn Leu 
    130                 135                 140                 


Arg Lys Val Val Pro Cys Tyr Ser Lys Thr Gln Lys Ala Ser Lys Ala 
145                 150                 155                 160 


Glu Thr Leu Arg Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile 
                165                 170                 175     


Leu Arg Ser Gly Lys Arg Pro Asp Leu Val Ser Tyr Val Gln Thr Leu 
            180                 185                 190         


Cys Lys Gly Leu Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu 
        195                 200                 205             


Gln Leu Asn Ser Arg Asn Phe Leu Thr Glu Gln Gly Ala Asp Gly Ala 
    210                 215                 220                 


Gly Arg Phe His Gly Ser Gly Gly Pro Phe Ala Met His Pro Tyr Pro 
225                 230                 235                 240 


Tyr Pro Cys Ser Arg Leu Ala Gly Ala Gln Cys Gln Ala Ala Gly Gly 
                245                 250                 255     


Leu Gly Gly Gly Ala Ala His Ala Leu Arg Thr His Gly Tyr Cys Ala 
            260                 265                 270         


Ala Tyr Glu Thr Leu Tyr Ala Ala Ala Gly Gly Gly Gly Ala Ser Pro 
        275                 280                 285             


Asp Tyr Asn Ser Ser Glu Tyr Glu Gly Pro Leu Ser Pro Pro Leu Cys 
    290                 295                 300                 


Leu Asn Gly Asn Phe Ser Leu Lys Gln Asp Ser Ser Pro Asp His Glu 
305                 310                 315                 320 


Lys Ser Tyr His Tyr Ser Met His Tyr Ser Ala Leu Pro Gly Ser Arg 
                325                 330                 335     


Pro Thr Gly His Gly Leu Val Phe Gly Ser Ser Ala Val Arg Gly Gly 
            340                 345                 350         


Val His Ser Glu Asn Leu Leu Ser Tyr Asp Met His Leu His His Asp 
        355                 360                 365             


Arg Gly Pro Met Tyr Glu Glu Leu Asn Ala Phe Phe His Asn 
    370                 375                 380         


<210>  77
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met Phe Val Lys Ser Glu Thr Ala Glu Ala Lys Glu Glu Glu Asp Val 
1               5                   10                  15      


Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 
            20                  25                  30          


Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 
        35                  40                  45              


Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 
    50                  55                  60                  


Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 
            180                 185                 190         


Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 
        195                 200                 205             


Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 
    210                 215                 220                 


Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 
225                 230                 235                 240 


Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 
                245                 250                 255     


Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 
            260                 265                 270         


<210>  78
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Thr Pro Gln Pro Ser Gly Ala Pro Thr Val Gln Val Thr Arg Glu 
1               5                   10                  15      


Thr Glu Arg Ser Phe Pro Arg Ala Ser Glu Asp Glu Val Thr Cys Pro 
            20                  25                  30          


Thr Ser Ala Pro Pro Ser Pro Thr Arg Thr Arg Gly Asn Cys Ala Glu 
        35                  40                  45              


Ala Glu Glu Gly Gly Cys Arg Gly Ala Pro Arg Lys Leu Arg Ala Arg 
    50                  55                  60                  


Arg Gly Gly Arg Ser Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln 
65                  70                  75                  80  


Arg Arg Ser Arg Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met 
                85                  90                  95      


His Asn Leu Asn Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr 
            100                 105                 110         


Phe Pro Asp Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala 
        115                 120                 125             


His Asn Tyr Ile Trp Ala Ala Thr Gln Thr Ala Arg Ile Ala Asp His 
    130                 135                 140                 


Ser Leu Tyr Ala Leu Glu Pro Pro Ala Pro His Cys Gly Glu Leu Gly 
145                 150                 155                 160 


Ser Pro Gly Gly Ser Pro Gly Asp Trp Gly Ser Leu Tyr Ser Pro Val 
                165                 170                 175     


Ser Gln Ala Gly Ser Leu Ser Pro Ala Ala Ser Leu Glu Glu Arg Pro 
            180                 185                 190         


Gly Leu Leu Gly Ala Thr Phe Ser Ala Cys Leu Ser Pro Gly Ser Leu 
        195                 200                 205             


Ala Phe Ser Asp Phe Leu 
    210                 


<210>  79
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Met Met Leu Ser Pro Asp Gln Ala Ala Asp Ser Asp His Pro Ser Ser 
1               5                   10                  15      


Ala His Ser Asp Pro Glu Ser Leu Gly Gly Thr Asp Thr Lys Val Leu 
            20                  25                  30          


Gly Ser Val Ser Asp Leu Glu Pro Val Glu Glu Ala Glu Gly Asp Gly 
        35                  40                  45              


Lys Gly Gly Ser Arg Ala Ala Leu Tyr Pro His Pro Gln Gln Leu Ser 
    50                  55                  60                  


Arg Glu Glu Lys Arg Arg Arg Arg Arg Ala Thr Ala Lys Tyr Arg Ser 
65                  70                  75                  80  


Ala His Ala Thr Arg Glu Arg Ile Arg Val Glu Ala Phe Asn Leu Ala 
                85                  90                  95      


Phe Ala Glu Leu Arg Lys Leu Leu Pro Thr Leu Pro Pro Asp Lys Lys 
            100                 105                 110         


Ala Ser Lys Ala Glu Ile Leu Arg Leu Ala Ile Cys Tyr Ile Ser Tyr 
        115                 120                 125             


Leu Asn His Val Leu Asp Val 
    130                 135 


<210>  80
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Glu Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Asn Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Ala Asp Ala Ala Gln Ser Leu Pro Leu Lys Asn Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Gly Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro 
            100                 105                 110         


Asp Asn Asp Lys Glu Thr Pro Gly Gly Gly Gly Asp Ala Gly Lys Lys 
        115                 120                 125             


Arg Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu 
    130                 135                 140                 


Arg Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His 
145                 150                 155                 160 


Leu Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met 
            180                 185                 190         


Glu Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu 
        195                 200                 205             


Val Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala 
    210                 215                 220                 


Ala Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln 
225                 230                 235                 240 


Ser Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr 
                245                 250                 255     


Pro Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr 
            260                 265                 270         


Trp 
    


<210>  81
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp 
1               5                   10                  15      


Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu 
            20                  25                  30          


Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu 
        35                  40                  45              


Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro 
    50                  55                  60                  


Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala 
65                  70                  75                  80  


Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala 
                85                  90                  95      


Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu 
            100                 105                 110         


Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp 
        115                 120                 125             


Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu 
    130                 135                 140                 


Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln 
145                 150                 155                 160 


Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Ala Ala Ser Ala Ala Lys 
                165                 170                 175     


Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys 
            180                 185                 190         


Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro 
        195                 200                 205             


Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val 
    210                 215                 220                 


Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala 
225                 230                 235                 240 


Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr 
                245                 250                 255     


Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala 
            260                 265                 270         


Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala 
        275                 280                 285             


Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln 
    290                 295                 300                 


Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly 
305                 310                 315                 320 


Ile Arg Ala Trp 
                


<210>  82
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Met Leu Ala Val Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Ala 
1               5                   10                  15      


Leu Ser Ser Pro Pro Ala Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Thr His Asn Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr 
                165                 170                 175     


Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys 
            180                 185                 190         


Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val 
        195                 200                 205             


Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His 
    210                 215                 220                 


Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg 
225                 230                 235                 240 


Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu 
                245                 250                 255     


Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser 
            260                 265                 270         


Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg 
        275                 280                 285             


Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys 
    290                 295                 300                 


Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp 
                325                 330                 335     


Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Gly Leu Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser 
        355                 360                 365         


<210>  83
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Met Tyr Arg Ser Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile 
1               5                   10                  15      


Asn Ala Glu Ile Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala 
            20                  25                  30          


Asp Lys Ala Arg Ala Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile 
        35                  40                  45              


Tyr Thr Arg Lys Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly 
    50                  55                  60                  


Pro Thr Gly Leu Leu Ser Ala Gln Glu Leu Glu Asp Ile Val Ala Ala 
65                  70                  75                  80  


Leu Pro Gly Phe Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr 
                85                  90                  95      


Leu Ser Glu Ser Val Ser Glu His Leu Gly His Ser Met Val Asp Leu 
            100                 105                 110         


Val Ala Gln Gly Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His 
        115                 120                 125             


Leu Thr Val Arg Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp 
    130                 135                 140                 


Arg Leu Phe Arg Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln 
145                 150                 155                 160 


Ser Ala Gly Asn Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His 
                165                 170                 175     


Pro Pro Gly Ala Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys 
            180                 185                 190         


Ala Pro Leu Glu Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly 
        195                 200                 205             


Pro Ala Ser Leu Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp 
    210                 215                 220                 


Leu Ala Leu Leu Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe 
225                 230                 235                 240 


Glu Arg Ser Glu Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro 
                245                 250                 255     


Glu Asp Leu Ala His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu 
            260                 265                 270         


Ser Gly Asp Ile Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr 
        275                 280                 285             


Gly Gly Trp Ala Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu 
    290                 295                 300                 


Gly Pro Ile Thr Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp 
305                 310                 315                 320 


Ser Leu Arg Gln Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val 
                325                 330                 335     


Leu Gly Thr Pro Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser 
            340                 345                 350         


Gln Glu Glu Cys Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly 
        355                 360                 365             


Ala Pro Arg Ser Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val 
    370                 375                 380                 


Ser Ala Ser Glu Glu Leu Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser 
385                 390                 395                 400 


Tyr Leu Thr Phe Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu 
                405                 410                 415     


Ser Lys Asp Leu Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly 
            420                 425                 430         


Gly Cys Ala Phe Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu 
        435                 440                 445             


Pro Thr Pro Ser Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala 
    450                 455                 460                 


Thr Phe Ser Asp Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro 
465                 470                 475                 480 


Leu Thr Ser Pro Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser 
                485                 490                 495     


Tyr Glu Asp Gln Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu 
            500                 505                 510         


Leu Pro Ser Thr Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His 
        515                 520                 525             


Glu Gln Leu Thr Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser 
    530                 535                 540                 


Pro Ser Gln Thr Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr 
545                 550                 555                 560 


Tyr Phe Ala Gln Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro 
                565                 570                 575     


Ser Pro Ser Ser Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala 
            580                 585                 590         


Gln Leu Arg Gly Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly 
        595                 600                 605             


Leu Leu Thr Pro Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr 
    610                 615                 620                 


Ser Glu Lys Glu Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser 
625                 630                 635                 640 


Gln Leu Ala Gln Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr 
                645                 650                 655     


Gly Gly Leu Glu Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu 
            660                 665                 670         


Ser Leu Ser Gly Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro 
        675                 680                 685             


Trp Lys Cys Gln Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe 
    690                 695                 700                 


Leu Glu Glu Thr Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro 
705                 710                 715                 720 


Asp Pro Ser Glu Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro 
                725                 730                 735     


Gly Gly Ala Pro Ser Pro Cys Asn Asn Leu Ser Pro Glu Asp His Ser 
            740                 745                 750         


Phe Leu Glu Asp Leu Ala Thr Tyr Glu Thr Ala Phe Glu Thr Gly Val 
        755                 760                 765             


Ser Ala Phe Pro Tyr Asp Gly Phe Thr Asp Glu Leu His Gln Leu Gln 
    770                 775                 780                 


Ser Gln Val Gln Asp Ser Phe His Glu Asp Gly Ser Gly Gly Glu Pro 
785                 790                 795                 800 


Thr Phe 
        


<210>  84
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Met Phe Tyr Ser Gly Leu Leu Thr Glu Gly Gly Arg Lys Glu Thr Asp 
1               5                   10                  15      


Met Arg Glu Ala Ala Ser Leu Arg Gln Gln Arg Arg Met Lys Gln Ala 
            20                  25                  30          


Val Gln Phe Ile His Lys Asp Ser Ala Asp Leu Leu Pro Leu Asp Gly 
        35                  40                  45              


Leu Lys Lys Leu Gly Ser Ser Lys Asp Met Gln Pro His Asn Ile Leu 
    50                  55                  60                  


Gln Arg Arg Leu Met Glu Thr Asn Leu Ser Lys Leu Arg Ser Gly Pro 
65                  70                  75                  80  


Arg Val Pro Trp Ala Ser Lys Thr Asn Lys Leu Asn Gln Ala Lys Ser 
                85                  90                  95      


Glu Gly Leu Lys Lys Ser Glu Glu Asp Asp Met Ile Leu Val Ser Cys 
            100                 105                 110         


Gln Cys Ala Gly Lys Asp Val Lys Ala Leu Val Asp Thr Gly Cys Leu 
        115                 120                 125             


Tyr Asn Leu Ile Ser Leu Ala Cys Val Asp Arg Leu Gly Leu Lys Glu 
    130                 135                 140                 


His Val Lys Ser His Lys His Glu Gly Glu Lys Leu Ser Leu Pro Arg 
145                 150                 155                 160 


His Leu Lys Val Val Gly Gln Ile Glu His Ala Val Ile Thr Ala Gly 
                165                 170                 175     


Ser Leu Arg Leu Asp Cys Pro Ala Ala Val Val Asp Asp Asn Glu Lys 
            180                 185                 190         


Asn Ala Ser Ala Gly Leu Gln Thr Leu Arg Ser Leu Lys Cys Ile Ile 
        195                 200                 205             


Asn Leu Asp Lys His Arg Leu Ile Met Gly Lys Thr Asp Lys Glu Glu 
    210                 215                 220                 


Ile Pro Phe Val Glu Thr Val Ser Leu Asn Glu Asp Asn Thr Ser Glu 
225                 230                 235                 240 


Ala 
    


<210>  85
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Ala Arg Pro Ala Ala Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  86
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Ala Gln Gln Ala Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210>  87
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Ala Ala Ala Lys Ala Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  88
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Met Ala Ala Leu Pro Gly Thr Val Pro Arg Met Met Arg Pro Ala Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp 
    130                 135                 140                 


Arg Ser Thr Val Pro Ser Gly Ala Val Ser Ser Ala Ser Arg Val Leu 
145                 150                 155                 160 


Arg Ile Lys Phe Gly Lys Lys Glu Glu Glu Asp Glu Ala Asp Lys Lys 
                165                 170                 175     


Glu Asp Asp Gly Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Gly Asp Lys Gly Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu 
        195                 200                 205             


Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe 
    210                 215                 220                 


Thr Ala Glu Gln Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His 
225                 230                 235                 240 


Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu 
                245                 250                 255     


Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp 
            260                 265                 270         


Arg Lys Gln Ala Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu 
        275                 280                 285             


Pro Gly Gly Phe Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln 
    290                 295                 300                 


Leu Pro Asp Ser Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly 
305                 310                 315                 320 


Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln 
                325                 330                 335     


Gly Gly Leu Ala Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr 
            340                 345                 350         


Gly Ala Arg His Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro 
        355                 360                 365             


Ala Ala Pro Ser Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Pro 
    370                 375                 380                 


Gln Val Met Ser Ile Leu Gly Asn Pro Ser Ala Val Pro Pro Gln Pro 
385                 390                 395                 400 


Gln Ala Asp Phe Ser Ile Ser Pro Leu His Gly Gly Leu Asp Ser Ala 
                405                 410                 415     


Thr Ser Ile Ser Ala Ser Cys Ser Gln Arg Ala Asp Ser Ile Lys Pro 
            420                 425                 430         


Gly Asp Ser Leu Pro Thr Ser Gln Ala Tyr Cys Pro Pro Thr Tyr Ser 
        435                 440                 445             


Thr Thr Gly Tyr Ser Val Asp Pro Val Ala Gly Tyr Gln Tyr Gly Gln 
    450                 455                 460                 


Tyr Gly Gln Ser Glu Cys Leu Val Pro Trp Ala Ser Pro Val Pro Ile 
465                 470                 475                 480 


Pro Ser Pro Thr Pro Arg Ala Ser Cys Leu Phe Met Glu Ser Tyr Lys 
                485                 490                 495     


Val Val Ser Gly Trp Gly Met Ser Ile Ser Gln Met Glu Lys Leu Lys 
            500                 505                 510         


Ser Ser Gln Met Glu Gln Phe Thr 
        515                 520 


<210>  89
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Ala His His His Ala Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro 
                245                 


<210>  90
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Met Glu Asp Thr Gly Ile Gln Arg Gly Ile Trp Asp Gly Asp Ala Lys 
1               5                   10                  15      


Ala Val Gln Gln Cys Leu Thr Asp Ile Phe Thr Ser Val Tyr Thr Thr 
            20                  25                  30          


Cys Asp Ile Pro Glu Asn Ala Ile Phe Gly Pro Cys Val Leu Ser His 
        35                  40                  45              


Thr Ser Leu Tyr Asp Ser Ile Ala Phe Ile Ala Leu Lys Ser Thr Asp 
    50                  55                  60                  


Lys Arg Thr Val Pro Tyr Ile Phe Arg Val Asp Thr Ser Ala Ala Asn 
65                  70                  75                  80  


Gly Ser Ser Glu Gly Leu Met Trp Leu Arg Leu Val Gln Ser Ala Arg 
                85                  90                  95      


Asp Lys Glu Glu Gln Asn Leu Glu Ala Tyr Ile Lys Asn Gly Gln Leu 
            100                 105                 110         


Phe Tyr Arg Ser Ala Arg Arg Ala Ala Lys Asp Glu Glu Leu Leu Val 
        115                 120                 125             


Trp Tyr Gly Lys Glu Leu Thr Glu Leu Leu Leu Leu Cys Pro Ser Arg 
    130                 135                 140                 


Ser His Asn Lys Met Asn Gly Ser Ser Pro Tyr Thr Cys Leu Glu Cys 
145                 150                 155                 160 


Ser Gln Arg Phe Gln Phe Glu Phe Pro Tyr Val Ala His Leu Arg Phe 
                165                 170                 175     


Arg Cys Pro Lys Arg Leu His Ser Ala Asp Ile Ser Pro Gln Asp Glu 
            180                 185                 190         


Gln Gly Gly Gly Val Gly Thr Lys Asp His Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Lys Asp Gln Gln Gln Gln Gln Gln Glu Ala Pro Leu Gly Pro Gly 
    210                 215                 220                 


Pro Lys Phe Cys Lys Ala Gly Pro Leu His His Tyr Pro Ser Pro Ser 
225                 230                 235                 240 


Pro Glu Ser Ser Asn Pro Ser Ala Ala Ala Gly Gly Ser Ser Ala Lys 
                245                 250                 255     


Pro Ser Thr Asp Phe His Asn Leu Ala Arg Glu Leu Glu Asn Ser Arg 
            260                 265                 270         


Gly Gly Ser Ser Cys Ser Pro Ala Gln Ser Leu Ser Ser Gly Ser Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Gly His Gln Glu Ala Glu Leu Ser Pro Asp Gly 
    290                 295                 300                 


Ile Ala Thr Gly Gly Gly Lys Gly Lys Arg Lys Phe Pro Glu Glu Ala 
305                 310                 315                 320 


Ala Glu Gly Gly Gly Gly Ala Gly Leu Val Gly Gly Arg Gly Arg Phe 
                325                 330                 335     


Val Glu Arg Pro Leu Pro Ala Ser Lys Glu Asp Leu Val Cys Thr Pro 
            340                 345                 350         


Gln Gln Tyr Arg Ala Ser Gly Ser Tyr Phe Gly Leu Glu Glu Asn Gly 
        355                 360                 365             


Arg Leu Phe Ala Pro Pro Ser Pro Glu Thr Gly Glu Ala Lys Arg Ser 
    370                 375                 380                 


Ala Phe Val Glu Val Lys Lys Ala Ala Arg Ala Ala Ser Leu Gln Glu 
385                 390                 395                 400 


Glu Gly Thr Ala Asp Gly Ala Gly Val Ala Ser Glu Asp Gln Asp Ala 
                405                 410                 415     


Gly Gly Gly Gly Gly Ser Ser Thr Pro Ala Ala Ala Ser Pro Val Gly 
            420                 425                 430         


Ala Glu Lys Leu Leu Ala Pro Arg Pro Gly Gly Pro Leu Pro Ser Arg 
        435                 440                 445             


Leu Glu Gly Gly Ser Pro Ala Arg Gly Ser Ala Phe Thr Ser Val Pro 
    450                 455                 460                 


Gln Leu Gly Ser Ala Gly Ser Thr Ser Gly Gly Gly Gly Thr Gly Ala 
465                 470                 475                 480 


Gly Ala Ala Gly Gly Ala Gly Gly Gly Gln Gly Ala Ala Ser Asp Glu 
                485                 490                 495     


Arg Lys Ser Ala Phe Ser Gln Pro Ala Arg Ser Phe Ser Gln Leu Ser 
            500                 505                 510         


Pro Leu Val Leu Gly Gln Lys Leu Gly Ala Leu Glu Pro Cys His Pro 
        515                 520                 525             


Ala Asp Gly Val Gly Pro Thr Arg Leu Tyr Pro Ala Ala Ala Asp Pro 
    530                 535                 540                 


Leu Ala Val Lys Leu Gln Gly Ala Ala Asp Leu Asn Gly Gly Cys Gly 
545                 550                 555                 560 


Ser Leu Pro Ser Gly Gly Gly Gly Leu Pro Lys Gln Ser Pro Phe Leu 
                565                 570                 575     


Tyr Ala Thr Ala Phe Trp Pro Lys Ser Ser Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Ala Ala Ala Ala Gly Pro Leu Gln Leu Gln Leu Pro Ser Ala 
        595                 600                 605             


Leu Thr Leu Leu Pro Pro Ser Phe Thr Ser Leu Cys Leu Pro Ala Gln 
    610                 615                 620                 


Asn Trp Cys Ala Lys Cys Asn Ala Ser Phe Arg Met Thr Ser Asp Leu 
625                 630                 635                 640 


Val Tyr His Met Arg Ser His His Lys Lys Glu Tyr Ala Met Glu Pro 
                645                 650                 655     


Leu Val Lys Arg Arg Arg Glu Glu Lys Leu Lys Cys Pro Ile Cys Asn 
            660                 665                 670         


Glu Ser Phe Arg Glu Arg His His Leu Ser Arg His Met Thr Ser His 
        675                 680                 685             


Asn 
    


<210>  91
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Met Glu Arg Arg Ser Glu Ser Pro Cys Leu Arg Asp Ser Pro Asp Arg 
1               5                   10                  15      


Arg Ser Gly Ser Pro Asp Val Lys Gly Pro Pro Pro Val Lys Val Ala 
            20                  25                  30          


Arg Leu Glu Gln Asn Gly Ser Pro Met Gly Ala Arg Gly Arg Pro Asn 
        35                  40                  45              


Gly Ala Val Ala Lys Ala Val Gly Gly Leu Met Ile Pro Val Phe Cys 
    50                  55                  60                  


Val Val Glu Gln Leu Asp Gly Ser Leu Glu Tyr Asp Asn Arg Glu Glu 
65                  70                  75                  80  


His Ala Glu Phe Val Leu Val Arg Lys Asp Val Leu Phe Ser Gln Leu 
                85                  90                  95      


Val Glu Thr Ala Leu Leu Ala Leu Gly Tyr Ser His Ser Ser Ala Ala 
            100                 105                 110         


Gln Ala Gln Gly Ile Ile Lys Leu Gly Arg Trp Asn Pro Leu Pro Leu 
        115                 120                 125             


Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln 
    130                 135                 140                 


Asp Val Tyr His Val Val Thr Leu Lys Ile Gln Leu Gln Ser Cys Ser 
145                 150                 155                 160 


Lys Leu Glu Asp Leu Pro Ala Glu Gln Trp Asn His Ala Thr Val Arg 
                165                 170                 175     


Asn Ala Leu Lys Glu Leu Leu Lys Glu Met Asn Gln Ser Thr Leu Ala 
            180                 185                 190         


Lys Glu Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser 
        195                 200                 205             


Thr Tyr Tyr Ala Asn Val Ser Ala Thr Lys Cys Gln Glu Phe Gly Arg 
    210                 215                 220                 


Trp Tyr Lys Lys Tyr Lys Lys Ile Lys Val Glu Arg Val Glu Arg Glu 
225                 230                 235                 240 


Asn Leu Ser Asp Tyr Cys Val Leu Gly Gln Arg Pro Met His Leu Pro 
                245                 250                 255     


Asn Met Asn Gln Leu Ala Ser Leu Gly Lys Thr Asn Glu Gln Ser Pro 
            260                 265                 270         


His Ser Gln Ile His His Ser Thr Pro Ile Arg Asn Gln Val Pro Ala 
        275                 280                 285             


Leu Gln Pro Ile Met Ser Pro Gly Leu Leu Ser Pro Gln Leu Ser Pro 
    290                 295                 300                 


Gln Leu Val Arg Gln Gln Ile Ala Met Ala His Leu Ile Asn Gln Gln 
305                 310                 315                 320 


Ile Ala Val Ser Arg Leu Leu Ala His Gln His Pro Gln Ala Ile Asn 
                325                 330                 335     


Gln Gln Phe Leu Asn His Pro Pro Ile Pro Arg Ala Val Lys Pro Glu 
            340                 345                 350         


Pro Thr Asn Ser Ser Val Glu Val Ser Pro Asp Ile Tyr Gln Gln Val 
        355                 360                 365             


Arg Asp Glu Leu Lys Arg Ala Ser Val Ser Gln Ala Val Phe Ala Arg 
    370                 375                 380                 


Val Ala Phe Asn Arg Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys 
385                 390                 395                 400 


Glu Glu Asp Pro Arg Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg 
                405                 410                 415     


Ala Met Gln Asn Phe Leu Asn Leu Pro Glu Val Glu Arg Asp Arg Ile 
            420                 425                 430         


Tyr Gln Asp Glu Arg Glu Arg Ser Met Asn Pro Asn Val Ser Met Val 
        435                 440                 445             


Ser Ser Ala Ser Ser Ser Pro Ser Ser Ser Arg Thr Pro Gln Ala Lys 
    450                 455                 460                 


Thr Ser Thr Pro Thr Thr Asp Leu Pro Ile Lys Val Asp Gly Ala Asn 
465                 470                 475                 480 


Ile Asn Ile Thr Ala Ala Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys 
                485                 490                 495     


Arg Ala Lys Val Ser Gln Ala Leu Phe Ala Lys Val Ala Ala Asn Lys 
            500                 505                 510         


Ser Gln Gly Trp Leu Cys Glu Leu Leu Arg Trp Lys Glu Asn Pro Ser 
        515                 520                 525             


Pro Glu Asn Arg Thr Leu Trp Glu Asn Leu Cys Thr Ile Arg Arg Phe 
    530                 535                 540                 


Leu Asn Leu Pro Gln His Glu Arg Asp Val Ile Tyr Glu Glu Glu Ser 
545                 550                 555                 560 


Arg His His His Ser Glu Arg Met Gln His Val Val Gln Leu Pro Pro 
                565                 570                 575     


Glu Pro Val Gln Val Leu His Arg Gln Gln Ser Gln Pro Ala Lys Glu 
            580                 585                 590         


Ser Ser Pro Pro Arg Glu Glu Ala Pro Pro Pro Pro Pro Pro Thr Glu 
        595                 600                 605             


Asp Ser Cys Ala Lys Lys Pro Arg Ser Arg Thr Lys Ala Ser Ala Glu 
    610                 615                 620                 


Ala Leu Gly Ile Leu Gln Ser Phe Ile His Asp Val Gly Leu Tyr Pro 
625                 630                 635                 640 


Asp Gln Glu Ala Ile His Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys 
                645                 650                 655     


His Thr Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr His Val Lys His 
            660                 665                 670         


His Gly Lys Leu Lys Glu His Leu Gly Ser Ala Val Asp Val Ala Glu 
        675                 680                 685             


Tyr Lys Asp Glu Glu Leu Leu Thr Glu Ser Glu Glu Asn Asp Ser Glu 
    690                 695                 700                 


Glu Gly Ser Glu Glu Met Tyr Lys Val Glu Ala Glu Glu Glu Asn Ala 
705                 710                 715                 720 


Asp Lys Ser Lys Ala Ala Pro Ala Glu Ile Asp Gln Arg 
                725                 730             


<210>  92
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Met Glu Glu Leu Thr Ala Phe Val Ser Lys Ser Phe Asp Gln Lys Val 
1               5                   10                  15      


Lys Glu Lys Lys Glu Ala Ile Thr Tyr Arg Glu Val Leu Glu Ser Gly 
            20                  25                  30          


Pro Leu Arg Gly Ala Lys Glu Pro Thr Gly Cys Thr Glu Ala Gly Arg 
        35                  40                  45              


Asp Asp Arg Ser Ser Pro Ala Val Arg Ala Ala Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly 
65                  70                  75                  80  


Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Arg Ser Pro Val Arg Glu 
                85                  90                  95      


Leu Asp Met Gly Ala Ala Glu Arg Ser Arg Glu Pro Gly Ser Pro Arg 
            100                 105                 110         


Leu Thr Glu Gly Arg Arg Lys Pro Thr Lys Ala Glu Val Gln Ala Thr 
        115                 120                 125             


Leu Leu Leu Pro Gly Glu Ala Phe Arg Phe Leu Val Ser Pro Glu Leu 
    130                 135                 140                 


Lys Asp Arg Lys Glu Asp Ala Lys Gly Met Glu Asp Glu Gly Gln Thr 
145                 150                 155                 160 


Lys Ile Lys Gln Arg Arg Ser Arg Thr Asn Phe Thr Leu Glu Gln Leu 
                165                 170                 175     


Asn Glu Leu Glu Arg Leu Phe Asp Glu Thr His Tyr Pro Asp Ala Phe 
            180                 185                 190         


Met Arg Glu Glu Leu Ser Gln Arg Leu Gly Leu Ser Glu Ala Arg Val 
        195                 200                 205             


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Cys Arg Lys Gln Glu Asn 
    210                 215                 220                 


Gln Leu His Lys Gly Val Leu Ile Gly Ala Ala Ser Gln Phe Glu Ala 
225                 230                 235                 240 


Cys Arg Val Ala Pro Tyr Val Asn Val Gly Ala Leu Arg Met Pro Phe 
                245                 250                 255     


Gln Gln Asp Ser His Cys Asn Val Thr Pro Leu Ser Phe Gln Val Gln 
            260                 265                 270         


Ala Gln Leu Gln Leu Asp Ser Ala Val Ala His Ala His His His Leu 
        275                 280                 285             


His Pro His Leu Ala Ala His Ala Pro Tyr Met Met Phe Pro Ala Pro 
    290                 295                 300                 


Pro Phe Gly Leu Pro Leu Ala Thr Leu Ala Ala Asp Ser Ala Ser Ala 
305                 310                 315                 320 


Ala Ser Val Val Ala Ala Ala Ala Ala Ala Lys Thr Thr Ser Lys Asn 
                325                 330                 335     


Ser Ser Ala Ala Asp Ala Arg Leu Lys Ala Lys Lys His Ala Ala Ala 
            340                 345                 350         


Leu Gly Leu 
        355 


<210>  93
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ala Ser Lys Arg Ala Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  94
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Met Asn Leu Leu Asp Pro Phe Met Lys Met Thr Asp Glu Gln Glu Lys 
1               5                   10                  15      


Gly Leu Ser Gly Ala Pro Ser Pro Thr Met Ser Glu Asp Ser Ala Gly 
            20                  25                  30          


Ser Pro Cys Pro Ser Gly Ser Gly Ser Asp Thr Glu Asn Thr Arg Pro 
        35                  40                  45              


Gln Glu Asn Thr Phe Pro Lys Gly Glu Pro Asp Leu Lys Lys Glu Ser 
    50                  55                  60                  


Glu Glu Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val 
65                  70                  75                  80  


Leu Lys Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn 
                85                  90                  95      


Gly Ser Ser Lys Asn Lys Pro His Val Lys Arg Pro Met Asn Ala Phe 
            100                 105                 110         


Met Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro 
        115                 120                 125             


His Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Ala Trp Arg 
    130                 135                 140                 


Leu Leu Asn Glu Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Arg Val Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro 
                165                 170                 175     


Arg Arg Arg Lys Ser Val Lys Asn Gly Gln Ala Glu Ala Glu Glu Ala 
            180                 185                 190         


Thr Glu Gln Thr His Ile Ser Pro Asn Ala Ile Phe Lys Ala Leu Gln 
        195                 200                 205             


Ala Asp Ser Pro His Ser Ser Ser Gly Met Ser Glu Val His Ser Pro 
    210                 215                 220                 


Gly Glu His Ser Gly Gln Ser Gln Gly Pro Pro Thr Pro Pro Thr Thr 
225                 230                 235                 240 


Pro Lys Thr Asp Val Gln Pro Gly Lys Ala Asp Leu Lys Arg Glu Gly 
                245                 250                 255     


Arg Pro Leu Pro Glu Gly Gly Arg Gln Pro Pro Ile Asp Phe Arg Asp 
            260                 265                 270         


Val Asp Ile Gly Glu Leu Ser Ser Asp Val Ile Ser Asn Ile Glu Thr 
        275                 280                 285             


Phe Asp Val Asn Glu Phe Asp Gln Tyr Leu Pro Pro Asn Gly His Pro 
    290                 295                 300                 


Gly Val Pro Ala Thr His Gly Gln Val Thr Tyr Thr Gly Ser Tyr Gly 
305                 310                 315                 320 


Ile Ser Ser Thr Ala Ala Thr Pro Ala Ser Ala Gly His Val Trp Met 
                325                 330                 335     


Ser Lys Gln Gln Ala Pro Pro Pro Pro Pro Gln Gln Pro Pro Gln Ala 
            340                 345                 350         


Pro Pro Ala Pro Gln Ala Pro Pro Gln Pro Gln Ala Ala Pro Pro Gln 
        355                 360                 365             


Gln Pro Ala Ala Pro Pro Gln Gln Pro Gln Ala His Thr Leu Thr Thr 
    370                 375                 380                 


Leu Ser Ser Glu Pro Gly Gln Ser Gln Arg Thr His Ile Lys Thr Glu 
385                 390                 395                 400 


Gln Leu Ser Pro Ser His Tyr Ser Glu Gln Gln Gln His Ser Pro Gln 
                405                 410                 415     


Gln Ile Ala Tyr Ser Pro Phe Asn Leu Pro His Tyr Ser Pro Ser Tyr 
            420                 425                 430         


Pro Pro Ile Thr Arg Ser Gln Tyr Asp Tyr Thr Asp His Gln Asn Ser 
        435                 440                 445             


Ser Ser Tyr Tyr Ser His Ala Ala Gly Gln Gly Thr Gly Leu Tyr Ser 
    450                 455                 460                 


Thr Phe Thr Tyr Met Asn Pro Ala Gln Arg Pro Met Tyr Thr Pro Ile 
465                 470                 475                 480 


Ala Asp Thr Ser Gly Val Pro Ser Ile Pro Gln Thr His Ser Pro Gln 
                485                 490                 495     


His Trp Glu Gln Pro Val Tyr Thr Gln Leu Thr Arg Pro 
            500                 505                 


<210>  95
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Met Gln Leu Glu His Cys Leu Ser Pro Ser Ile Met Leu Ser Lys Lys 
1               5                   10                  15      


Phe Leu Asn Val Ser Ser Ser Tyr Pro His Ser Gly Gly Ser Glu Leu 
            20                  25                  30          


Val Leu His Asp His Pro Ile Ile Ser Thr Thr Asp Asn Leu Glu Arg 
        35                  40                  45              


Ser Ser Pro Leu Lys Lys Ile Thr Arg Gly Met Thr Asn Gln Ser Asp 
    50                  55                  60                  


Thr Asp Asn Phe Pro Asp Ser Lys Asp Ser Pro Gly Asp Val Gln Arg 
65                  70                  75                  80  


Ser Lys Leu Ser Pro Val Leu Asp Gly Val Ser Glu Leu Arg His Ser 
                85                  90                  95      


Phe Asp Gly Ser Ala Ala Asp Arg Tyr Leu Leu Ser Gln Ser Ser Gln 
            100                 105                 110         


Pro Gln Ser Ala Ala Thr Ala Pro Ser Ala Met Phe Pro Tyr Pro Gly 
        115                 120                 125             


Gln His Gly Pro Ala His Pro Ala Phe Ser Ile Gly Ser Pro Ser Arg 
    130                 135                 140                 


Tyr Met Ala His His Pro Val Ile Thr Asn Gly Ala Tyr Asn Ser Leu 
145                 150                 155                 160 


Leu Ser Asn Ser Ser Pro Gln Gly Tyr Pro Thr Ala Gly Tyr Pro Tyr 
                165                 170                 175     


Pro Gln Gln Tyr Gly His Ser Tyr Gln Gly Ala Pro Phe Tyr Gln Phe 
            180                 185                 190         


Ser Ser Thr Gln Pro Gly Leu Val Pro Gly Lys Ala Gln Val Tyr Leu 
        195                 200                 205             


Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met 
    210                 215                 220                 


Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn 
225                 230                 235                 240 


Ile Ser Gly Leu Asp Pro Thr Ala His Tyr Asn Ile Phe Val Asp Val 
                245                 250                 255     


Ile Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val 
            260                 265                 270         


Pro Cys Gly Lys Ala Asp Thr Asn Val Gln Gly Asn Arg Val Tyr Met 
        275                 280                 285             


His Pro Asp Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Ile 
    290                 295                 300                 


Ser Ala Gly Lys Ala Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn 
305                 310                 315                 320 


Asn Gly Gln Met Val Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg 
                325                 330                 335     


Leu His Val Val Glu Val Asn Glu Asp Gly Thr Glu Asp Thr Ser Gln 
            340                 345                 350         


Pro Gly Arg Val Gln Thr Phe Thr Phe Pro Glu Thr Gln Phe Ile Ala 
        355                 360                 365             


Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His 
    370                 375                 380                 


Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Thr Ile Tyr Thr 
385                 390                 395                 400 


Gly Cys Asp Met Asp Arg Leu Thr Pro Ser Pro Asn Asp Ser Pro Arg 
                405                 410                 415     


Ser Gln Ile Val Pro Gly Ala Arg Tyr Ala Met Ala Gly Ser Phe Leu 
            420                 425                 430         


Gln Asp Gln Phe Val Ser Asn Tyr Ala Lys Ala Arg Phe His Pro Gly 
        435                 440                 445             


Ala Gly Ala Gly Pro Gly Pro Gly Thr Asp Arg Ser Val Pro His Thr 
    450                 455                 460                 


Asn Gly Leu Leu Ser Pro Gln Gln Ala Glu Asp Pro Gly Ala Pro Ser 
465                 470                 475                 480 


Pro Gln Arg Trp Phe Val Thr Pro Ala Asn Asn Arg Leu Asp Phe Ala 
                485                 490                 495     


Ala Ser Ala Tyr Asp Thr Ala Thr Asp Phe Ala Gly Asn Ala Ala Thr 
            500                 505                 510         


Leu Leu Ser Tyr Ala Ala Ala Gly Val Lys Ala Leu Pro Leu Gln Ala 
        515                 520                 525             


Ala Gly Cys Thr Gly Arg Pro Leu Gly Tyr Tyr Ala Asp Pro Ser Gly 
    530                 535                 540                 


Trp Gly Ala Arg Ser Pro Pro Gln Tyr Cys Gly Thr Lys Ser Gly Ser 
545                 550                 555                 560 


Val Leu Pro Cys Trp Pro Asn Ser Ala Ala Ala Ala Ala Arg Met Ala 
                565                 570                 575     


Gly Ala Asn Pro Tyr Leu Gly Glu Glu Ala Glu Gly Leu Ala Ala Glu 
            580                 585                 590         


Arg Ser Pro Leu Pro Pro Gly Ala Ala Glu Asp Ala Lys Pro Lys Asp 
        595                 600                 605             


Leu Ser Asp Ser Ser Trp Ile Glu Thr Pro Ser Ser Ile Lys Ser Ile 
    610                 615                 620                 


Asp Ser Ser Asp Ser Gly Ile Tyr Glu Gln Ala Lys Arg Arg Arg Ile 
625                 630                 635                 640 


Ser Pro Ala Asp Thr Pro Val Ser Glu Ser Ser Ser Pro Leu Lys Ser 
                645                 650                 655     


Glu Val Leu Ala Gln Arg Asp Cys Glu Lys Asn Cys Ala Lys Asp Ile 
            660                 665                 670         


Ser Gly Tyr Tyr Gly Phe Tyr Ser His Ser 
        675                 680         


<210>  96
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Met Ala Asp Ala Asp Glu Ala Leu Ala Gly Ala His Leu Trp Ser Leu 
1               5                   10                  15      


Thr Gln Lys Thr Cys Leu Arg Phe Glu Pro Arg Ala Arg Ser Gly Pro 
            20                  25                  30          


Pro Ala Ser Pro Pro Gly Arg Pro Arg Ser Arg Leu His Pro Ala Gly 
        35                  40                  45              


Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys 
    50                  55                  60                  


Phe His Glu Val Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met 
65                  70                  75                  80  


Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Ile Asn Pro Lys Thr Lys 
                85                  90                  95      


Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys 
            100                 105                 110         


Phe Ala Asp Asn Lys Trp Cys Val Thr Gly Lys Ala Glu Pro Ala Met 
        115                 120                 125             


Ala Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His 
    130                 135                 140                 


Trp Met Arg Gln Ala Val Ser Ala Gln Lys Leu Lys Leu Thr Asn Asn 
145                 150                 155                 160 


His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr 
                165                 170                 175     


Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe Gly 
            180                 185                 190         


Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala Phe 
        195                 200                 205             


Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile 
    210                 215                 220                 


Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met Glu 
225                 230                 235                 240 


Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val Pro 
                245                 250                 255     


Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe Ser 
            260                 265                 270         


Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln Tyr 
        275                 280                 285             


Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro Pro 
    290                 295                 300                 


Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His Cys 
305                 310                 315                 320 


Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr Lys 
                325                 330                 335     


Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr Arg 
            340                 345                 350         


Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr Glu 
        355                 360                 365             


Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro Ser 
    370                 375                 380                 


Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro Ser 
385                 390                 395                 400 


Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln Pro Trp Thr 
                405                 410                 415     


Gly Tyr Pro Thr Ser Thr Ser Pro Leu Thr Ser Pro Arg Gly Pro Trp 
            420                 425                 430         


Ser Leu Gly Trp Leu Ala Trp Gln Pro Trp Leu Pro Thr Ala Gly Arg 
        435                 440                 445             


Gly Asn Val Pro Ser Thr Arg Pro Pro Val Ala His Gln Pro Val Val 
    450                 455                 460                 


Ser Ser Val Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu Gln 
465                 470                 475                 480 


Pro Pro Glu Phe Leu Tyr Ser His Gly Val Gln Gly Leu Tyr Pro Leu 
                485                 490                 495     


Ile Ser Thr Thr Leu Cys Thr Glu Leu Ala Trp Cys Arg Val Glu Arg 
            500                 505                 510         


Gln 
    


<210>  97
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Met Ala Glu Lys Arg Arg Gly Ser Pro Cys Ser Met Leu Ser Leu Lys 
1               5                   10                  15      


Ala His Ala Phe Ser Val Glu Ala Leu Ile Gly Ala Glu Lys Gln Gln 
            20                  25                  30          


Gln Leu Gln Lys Lys Arg Arg Lys Leu Gly Ala Glu Glu Ala Ala Gly 
        35                  40                  45              


Ala Val Asp Asp Gly Gly Cys Ser Arg Gly Gly Gly Ala Gly Glu Lys 
    50                  55                  60                  


Gly Ser Ser Glu Gly Asp Glu Gly Ala Ala Leu Pro Pro Pro Ala Gly 
65                  70                  75                  80  


Ala Thr Ser Gly Pro Ala Arg Ser Gly Ala Asp Leu Glu Arg Gly Ala 
                85                  90                  95      


Ala Gly Gly Cys Glu Asp Gly Phe Gln Gln Gly Ala Ser Pro Leu Ala 
            100                 105                 110         


Ser Pro Gly Gly Ser Pro Lys Gly Ser Pro Ala Arg Ser Leu Ala Arg 
        115                 120                 125             


Pro Gly Thr Pro Leu Pro Ser Pro Gln Ala Pro Arg Val Asp Leu Gln 
    130                 135                 140                 


Gly Ala Glu Leu Trp Lys Arg Phe His Glu Ile Gly Thr Glu Met Ile 
145                 150                 155                 160 


Ile Thr Lys Ala Gly Arg Arg Met Phe Pro Ala Met Arg Val Lys Ile 
                165                 170                 175     


Ser Gly Leu Asp Pro His Gln Gln Tyr Tyr Ile Ala Met Asp Ile Val 
            180                 185                 190         


Pro Val Asp Asn Lys Arg Tyr Arg Tyr Val Tyr His Ser Ser Lys Trp 
        195                 200                 205             


Met Val Ala Gly Asn Ala Asp Ser Pro Val Pro Pro Arg Val Tyr Ile 
    210                 215                 220                 


His Pro Asp Ser Pro Ala Ser Gly Glu Thr Trp Met Arg Gln Ala Ile 
225                 230                 235                 240 


Ser Ala Asp Lys Leu Lys Leu Thr Asn Asn Glu Leu Asp Asp Gln Gly 
                245                 250                 255     


His Ile Ile Leu His Ser Met His Lys Tyr Gln Pro Arg Val His Val 
            260                 265                 270         


Ile Arg Lys Asp Cys Gly Asp Asp Leu Ser Pro Ile Lys Pro Val Pro 
        275                 280                 285             


Ser Gly Glu Gly Val Lys Ala Phe Ser Phe Pro Glu Thr Val Phe Thr 
    290                 295                 300                 


Thr Val Thr Ala Tyr Gln Asn Gln Gln Ile Thr Arg Leu Lys Ile Asp 
305                 310                 315                 320 


Arg Asn Pro Phe Ala Lys Gly Phe Arg Asp Ser Gly Arg Asn Arg Met 
                325                 330                 335     


Gly Leu Glu Ala Leu Val Glu Ser Tyr Ala Phe Trp Arg Pro Ser Leu 
            340                 345                 350         


Arg Thr Leu Thr Phe Glu Asp Ile Pro Gly Ile Pro Lys Gln Gly Asn 
        355                 360                 365             


Ala Ser Ser Ser Thr Leu Leu Gln Gly Thr Gly Asn Gly Val Pro Ala 
    370                 375                 380                 


Thr His Pro His Leu Leu Ser Gly Ser Ser Cys Ser Ser Pro Ala Phe 
385                 390                 395                 400 


His Leu Gly Pro Asn Thr Ser Gln Leu Cys Ser Leu Ala Pro Ala Asp 
                405                 410                 415     


Tyr Ser Ala Cys Ala Arg Ser Gly Leu Thr Leu Asn Arg Tyr Ser Thr 
            420                 425                 430         


Ser Leu Ala Glu Thr Tyr Asn Arg Leu Thr Asn Gln Ala Gly Glu Thr 
        435                 440                 445             


Phe Ala Pro Pro Arg Thr Pro Ser Tyr Val Gly Val Ser Ser Ser Thr 
    450                 455                 460                 


Ser Val Asn Met Ser Met Gly Gly Thr Asp Gly Asp Thr Phe Ser Cys 
465                 470                 475                 480 


Pro Gln Thr Ser Leu Ser Met Gln Ile Ser Gly Met Ser Pro Gln Leu 
                485                 490                 495     


Gln Tyr Ile Met Pro Ser Pro Ser Ser Asn Ala Phe Ala Thr Asn Gln 
            500                 505                 510         


Thr His Gln Gly Ser Tyr Asn Thr Phe Arg Leu His Ser Pro Cys Ala 
        515                 520                 525             


Leu Tyr Gly Tyr Asn Phe Ser Thr Ser Pro Lys Leu Ala Ala Ser Pro 
    530                 535                 540                 


Glu Lys Ile Val Ser Ser Gln Gly Ser Phe Leu Gly Ser Ser Pro Ser 
545                 550                 555                 560 


Gly Thr Met Thr Asp Arg Gln Met Leu Pro Pro Val Glu Gly Val His 
                565                 570                 575     


Leu Leu Ser Ser Gly Gly Gln Gln Ser Phe Phe Asp Ser Arg Thr Leu 
            580                 585                 590         


Gly Ser Leu Thr Leu Ser Ser Ser Gln Val Ser Ala His Met Val 
        595                 600                 605         


<210>  98
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Met Leu Leu Asp Ala Gly Pro Gln Tyr Pro Ala Ile Gly Val Thr Thr 
1               5                   10                  15      


Phe Gly Ala Ser Arg His His Ser Ala Gly Asp Ala Ala Glu Arg Asp 
            20                  25                  30          


Ala Gly Leu Gly Ile Asn Pro Phe Ala Asp Gly Met Gly Ala Phe Lys 
        35                  40                  45              


Leu Asn Pro Ser Ser His Glu Leu Ala Ser Ala Gly Gln Thr Ala Phe 
    50                  55                  60                  


Thr Ser Gln Ala Pro Gly Tyr Ala Ala Ala Ala Ala Leu Gly His His 
65                  70                  75                  80  


His His Pro Gly His Val Gly Ser Tyr Ser Ser Ala Ala Phe Asn Ser 
                85                  90                  95      


Thr Arg Asp Phe Leu Phe Arg Asn Arg Gly Phe Gly Asp Ala Ala Ala 
            100                 105                 110         


Ala Ala Ser Ala Gln His Ser Leu Phe Ala Ala Ser Ala Gly Gly Phe 
        115                 120                 125             


Gly Gly Pro His Gly His Thr Asp Ala Ala Gly His Leu Leu Phe Pro 
    130                 135                 140                 


Gly Leu His Glu Gln Ala Ala Gly His Ala Ser Pro Asn Val Val Asn 
145                 150                 155                 160 


Gly Gln Met Arg Leu Gly Phe Ser Gly Asp Met Tyr Pro Arg Pro Glu 
                165                 170                 175     


Gln Tyr Gly Gln Val Thr Ser Pro Arg Ser Glu His Tyr Ala Ala Pro 
            180                 185                 190         


Gln Leu His Gly Tyr Gly Pro Met Asn Val Asn Met Ala Ala His His 
        195                 200                 205             


Gly Ala Gly Ala Phe Phe Arg Tyr Met Arg Gln Pro Ile Lys Gln Glu 
    210                 215                 220                 


Leu Ile Cys Lys Trp Ile Glu Pro Glu Gln Leu Ala Asn Pro Lys Lys 
225                 230                 235                 240 


Ser Cys Asn Lys Thr Phe Ser Thr Met His Glu Leu Val Thr His Val 
                245                 250                 255     


Thr Val Glu His Val Gly Gly Pro Glu Gln Ser Asn His Ile Cys Phe 
            260                 265                 270         


Trp Glu Glu Cys Pro Arg Glu Gly Lys Pro Phe Lys Ala Lys Tyr Lys 
        275                 280                 285             


Leu Val Asn His Ile Arg Val His Thr Gly Glu Lys Pro Phe Pro Cys 
    290                 295                 300                 


Pro Phe Pro Gly Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys 
305                 310                 315                 320 


Ile His Lys Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys Glu Phe 
                325                 330                 335     


Glu Gly Cys Asp Arg Arg Phe Ala Asn Ser Ser Asp Arg Lys Lys His 
            340                 345                 350         


Met His Val His Thr Ser Asp Lys Pro Tyr Leu Cys Lys Met Cys Asp 
        355                 360                 365             


Lys Ser Tyr Thr His Pro Ser Ser Leu Arg Lys His Met Lys Val His 
    370                 375                 380                 


Glu Ser Ser Ser Gln Gly Ser Gln Pro Ser Pro Ala Ala Ser Ser Gly 
385                 390                 395                 400 


Tyr Glu Ser Ser Thr Pro Pro Thr Ile Val Ser Pro Ser Thr Asp Asn 
                405                 410                 415     


Pro Thr Thr Ser Ser Leu Ser Pro Ser Ser Ser Ala Val His His Thr 
            420                 425                 430         


Ala Gly His Ser Ala Leu Ser Ser Asn Phe Asn Glu Trp Tyr Val 
        435                 440                 445         


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Glu Ser Gly Gly Gly Gly Ser Pro Gly 
1               5                   


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His 
1               5                   10              


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  103
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  105
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys 
225                 230                 235                 


<210>  106
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His 
            20  


<210>  107
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Ser Ser 
                245                 250                 255     


Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro Gln Pro Gln Pro 
            260                 265                 270         


Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln 
    290                 295                 300                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro Gln Leu Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys Ser Ala Pro Lys 
                325                 330                 335     


Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu Met Arg Cys Lys 
            340                 345                 350         


Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln 
        355                 360                 365             


Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys 
    370                 375                 380                 


Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly 
385                 390                 395                 400 


Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu Arg Ser Ala Val 
                405                 410                 415     


Glu Tyr Ile Arg Ala Ala Gln Gln Leu Leu Asp Glu His Asp Ala Val 
            420                 425                 430         


Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr Ile Ser Pro Asn 
        435                 440                 445             


Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro Val Ser Ser Tyr 
    450                 455                 460                 


Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro Glu Glu Gln Glu 
465                 470                 475                 480 


Leu Leu Asp Phe Thr Asn Trp Phe Glu Ser Gly Gly Gly Gly Ser Pro 
                485                 490                 495     


Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            500                 505             


<210>  108
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Ala Asp 
                245                 250                 255     


Glu Val Ala Gly Gly Ala Arg Lys Ala Thr Lys Ser Lys Leu Phe Glu 
            260                 265                 270         


Phe Leu Val His Gly Val Arg Pro Gly Met Pro Ser Gly Ala Arg Met 
        275                 280                 285             


Pro His Gln Gly Ala Pro Met Gly Pro Pro Gly Ser Pro Tyr Met Gly 
    290                 295                 300                 


Ser Pro Ala Val Arg Pro Gly Leu Ala Pro Ala Gly Met Glu Pro Ala 
305                 310                 315                 320 


Arg Lys Arg Ala Ala Pro Pro Pro Gly Gln Ser Gln Ala Gln Ser Gln 
                325                 330                 335     


Gly Gln Pro Val Pro Thr Ala Pro Ala Arg Ser Arg Ser Ala Lys Arg 
            340                 345                 350         


Arg Lys Met Ala Asp Lys Ile Leu Pro Gln Arg Ile Arg Glu Leu Val 
        355                 360                 365             


Pro Glu Ser Gln Ala Tyr Met Asp Leu Leu Ala Phe Glu Arg Lys Leu 
    370                 375                 380                 


Asp Gln Thr Ile Met Arg Lys Arg Val Asp Ile Gln Glu Ala Leu Lys 
385                 390                 395                 400 


Arg Pro Met Lys Gln Lys Arg Lys Leu Arg Leu Tyr Ile Ser Asn Thr 
                405                 410                 415     


Phe Asn Pro Ala Lys Pro Asp Ala Glu Asp Ser Asp Gly Ser Ile Ala 
            420                 425                 430         


Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp Asp Pro Ser Lys 
        435                 440                 445             


Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu Val Ile Glu Leu 
    450                 455                 460                 


Asp Lys Asp Leu Tyr Gly Pro Asp Asn His Leu Val Glu Trp His Arg 
465                 470                 475                 480 


Thr Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val Lys Arg Pro Gly 
                485                 490                 495     


Asp Leu Ser Val Arg Cys Thr Leu Leu Leu Met Leu Asp Tyr Gln Pro 
            500                 505                 510         


Pro Gln Phe Lys Leu Asp Pro Arg Ala Ala Arg Ala Ala Gly Leu His 
        515                 520                 525             


Thr Gln Ser Arg Ser Ala Ile Val Gln Ala Leu Trp Gln Tyr Val Lys 
    530                 535                 540                 


Thr Asn Arg Leu Gln Asp Ser His Asp Lys Glu Tyr Ile Asn Gly Asp 
545                 550                 555                 560 


Lys Tyr Phe Gln Gln Ile Phe Asp Cys Pro Arg Leu Lys Phe Ser Glu 
                565                 570                 575     


Ile Pro Gln Arg Leu Thr Ala Leu Leu Leu Pro Pro Asp Pro Ile Val 
            580                 585                 590         


Ile Asn His Val Ile Ser Val Asp Pro Ser Asp Gln Lys Lys Thr Ala 
        595                 600                 605             


Cys Tyr Asp Ile Asp Val Glu Val Glu Glu Pro Leu Lys Gly Gln Met 
    610                 615                 620                 


Ser Ser Phe Leu Leu Ser Thr Ala Asn Gln Gln Glu Ile Ser Ala Leu 
625                 630                 635                 640 


Asp Ser Lys Ile His Glu Thr Ile Glu Ser Ile Asn Gln Leu Lys Ile 
                645                 650                 655     


Gln Arg Asp Phe Met Leu Ser Phe Ser Arg Asp Pro Lys Gly Tyr Val 
            660                 665                 670         


Gln Asp Leu Leu Arg Ser Gln Ser Arg Asp Leu Lys Val Met Thr Asp 
        675                 680                 685             


Val Ala Gly Asn Pro Glu Glu Glu Arg Arg Ala Glu Phe Tyr His Gln 
    690                 695                 700                 


Pro Trp Ser Gln Glu Ala Val Ser Arg Tyr Phe Tyr Cys Lys Ile Gln 
705                 710                 715                 720 


Gln Arg Arg Gln Glu Leu Glu Gln Ser Leu Val Val Arg Asn Thr Glu 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg 
            740                 745                 750         


Arg Arg Arg 
        755 


<210>  109
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Thr Ala 
                245                 250                 255     


Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala Ser Ile Val His 
            260                 265                 270         


Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly Gly Tyr Arg Glu 
        275                 280                 285             


Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu Gln Ser Asn Gly 
    290                 295                 300                 


His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala Leu Ser His Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                325                 330                 335     


Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser Pro Leu Gly Gln 
            340                 345                 350         


Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly Gly Arg Gly Asp 
        355                 360                 365             


Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His Gln Gln Gln Gln 
    370                 375                 380                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
385                 390                 395                 400 


Gln Arg Pro Pro His Leu Val His His Ala Ala Asn His His Pro Gly 
                405                 410                 415     


Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His Leu Pro Pro Ser 
            420                 425                 430         


Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln Pro Ser Phe Thr 
        435                 440                 445             


Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala Gly Leu His His 
    450                 455                 460                 


His Gly Leu Arg Asp Ala His Asp Glu Pro His His Ala Asp His His 
465                 470                 475                 480 


Pro His Pro His Ser His Pro His Gln Gln Pro Pro Pro Pro Pro Pro 
                485                 490                 495     


Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His Asp Pro His Ser 
            500                 505                 510         


Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln Phe Ala Lys Gln 
        515                 520                 525             


Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Ala Asp Val Gly 
    530                 535                 540                 


Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser Gln Thr Thr Ile 
545                 550                 555                 560 


Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn Met Cys Lys Leu 
                565                 570                 575     


Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp Ser Ser Ser Gly 
            580                 585                 590         


Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly Arg Lys Arg Lys 
        595                 600                 605             


Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala Leu Glu Ser His 
    610                 615                 620                 


Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile Thr Ser Ala Ala 
625                 630                 635                 640 


Asp Ser Ala Gln Leu Glu Lys Glu Val Val Arg Val Trp Phe Cys Asn 
                645                 650                 655     


Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly Gly Thr Leu Pro 
            660                 665                 670         


Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr Pro Pro His His 
        675                 680                 685             


Gly Val Gln Thr Pro Val Gln Glu Ser Gly Gly Gly Gly Ser Pro Gly 
    690                 695                 700                 


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
705                 710                 715 


<210>  110
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Thr Ala 
                245                 250                 255     


Ala Ser Asn Pro Tyr Ser Ile Leu Ser Ser Thr Ser Leu Val His Ala 
            260                 265                 270         


Asp Ser Ala Gly Met Gln Gln Gly Ser Pro Phe Arg Asn Pro Gln Lys 
        275                 280                 285             


Leu Leu Gln Ser Asp Tyr Leu Gln Gly Val Pro Ser Asn Gly His Pro 
    290                 295                 300                 


Leu Gly His His Trp Val Thr Ser Leu Ser Asp Gly Gly Pro Trp Ser 
305                 310                 315                 320 


Ser Thr Leu Ala Thr Ser Pro Leu Asp Gln Gln Asp Val Lys Pro Gly 
                325                 330                 335     


Arg Glu Asp Leu Gln Leu Gly Ala Ile Ile His His Arg Ser Pro His 
            340                 345                 350         


Val Ala His His Ser Pro His Thr Asn His Pro Asn Ala Trp Gly Ala 
        355                 360                 365             


Ser Pro Ala Pro Asn Pro Ser Ile Thr Ser Ser Gly Gln Pro Leu Asn 
    370                 375                 380                 


Val Tyr Ser Gln Pro Gly Phe Thr Val Ser Gly Met Leu Glu His Gly 
385                 390                 395                 400 


Gly Leu Thr Pro Pro Pro Ala Ala Ala Ser Ala Gln Ser Leu His Pro 
                405                 410                 415     


Val Leu Arg Glu Pro Pro Asp His Gly Glu Leu Gly Ser His His Cys 
            420                 425                 430         


Gln Asp His Ser Asp Glu Glu Thr Pro Thr Ser Asp Glu Leu Glu Gln 
        435                 440                 445             


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
    450                 455                 460                 


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
465                 470                 475                 480 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
                485                 490                 495     


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
            500                 505                 510         


Ser Ser Thr Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
        515                 520                 525             


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Val 
    530                 535                 540                 


Leu Glu Thr His Phe Leu Lys Cys Pro Lys Pro Ala Ala Gln Glu Ile 
545                 550                 555                 560 


Ser Ser Ala Ala Asp Ser Ala Gln Leu Glu Lys Glu Val Val Arg Val 
                565                 570                 575     


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
            580                 585                 590         


Asp Gln Gln Pro His Glu Val Tyr Ser His Thr Val Lys Thr Asp Thr 
        595                 600                 605             


Ser Cys His Asp Leu Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg 
    610                 615                 620                 


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
625                 630             


<210>  111
<211>  2226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Arg Gly Pro 
                245                 250                 255     


Val Gly Thr Glu Glu Glu Leu Pro Arg Leu Phe Ala Glu Glu Met Glu 
            260                 265                 270         


Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly Leu Glu Ala Phe 
        275                 280                 285             


Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro Lys Lys Lys Lys 
    290                 295                 300                 


Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys Arg Lys Lys Lys 
305                 310                 315                 320 


Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu Asp Leu Glu Glu 
                325                 330                 335     


Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn Lys Lys Lys Lys 
            340                 345                 350         


Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys Arg Lys Lys Lys 
        355                 360                 365             


Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu Lys Glu Pro Lys 
    370                 375                 380                 


Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp Asp Val Asp Tyr 
385                 390                 395                 400 


Leu Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn Tyr Lys Ala Phe 
                405                 410                 415     


Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn Pro Lys Ile Pro 
            420                 425                 430         


Met Ser Lys Met Met Thr Val Leu Gly Ala Lys Trp Arg Glu Phe Ser 
        435                 440                 445             


Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Val Ala Ala Ala Val Glu Thr Val Thr Ile Ser Pro Pro Leu Ala Val 
465                 470                 475                 480 


Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg Lys Ala Lys Thr 
                485                 490                 495     


Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile Lys Gly Ser Lys 
            500                 505                 510         


Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Thr Ala Gly Leu Lys Phe 
        515                 520                 525             


Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly Ser Ser Ser Glu 
    530                 535                 540                 


Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala Ser Ile His Ser 
545                 550                 555                 560 


Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly Lys Lys Ser Lys 
                565                 570                 575     


Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp Gly Tyr Glu Thr 
            580                 585                 590         


Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile 
        595                 600                 605             


Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val Cys Leu Asp Pro 
    610                 615                 620                 


Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu 
625                 630                 635                 640 


Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp Asp Glu Glu Glu 
                645                 650                 655     


Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met Glu Phe Cys Arg 
            660                 665                 670         


Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Pro Ser 
        675                 680                 685             


Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro Glu Ile Pro Asn 
    690                 695                 700                 


Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro Pro Leu Lys Gly Lys 
705                 710                 715                 720 


Val Gln Arg Ile Leu His Trp Arg Trp Thr Glu Pro Pro Ala Pro Phe 
                725                 730                 735     


Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser Leu Pro Pro Pro 
            740                 745                 750         


Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe Val Lys Trp Ala 
        755                 760                 765             


Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu Leu Gln Leu Glu 
    770                 775                 780                 


Leu Tyr His Thr Val Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met 
785                 790                 795                 800 


Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp Glu Asp Gly Lys 
                805                 810                 815     


Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala Lys Met Glu Glu 
            820                 825                 830         


Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile His Arg 
        835                 840                 845             


Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val His Tyr Leu Ile 
    850                 855                 860                 


Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Thr Trp Glu Ile Asp Asp 
865                 870                 875                 880 


Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala Tyr Trp Gly His 
                885                 890                 895     


Arg Glu Leu Met Leu Gly Glu Asp Thr Arg Leu Pro Lys Arg Leu Leu 
            900                 905                 910         


Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu Lys Pro Pro Asp 
        915                 920                 925             


Thr Pro Ile Val Asp Pro Thr Val Lys Phe Asp Lys Gln Pro Trp Tyr 
    930                 935                 940                 


Ile Asp Ser Thr Gly Gly Thr Leu His Pro Tyr Gln Leu Glu Gly Leu 
945                 950                 955                 960 


Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala 
                965                 970                 975     


Asp Glu Met Gly Leu Gly Lys Thr Val Gln Thr Ile Val Phe Leu Tyr 
            980                 985                 990         


Ser Leu Tyr Lys Glu Gly His Ser  Lys Gly Pro Tyr Leu  Val Ser Ala 
        995                 1000                 1005             


Pro Leu  Ser Thr Ile Ile Asn  Trp Glu Arg Glu Phe  Glu Met Trp 
    1010                 1015                 1020             


Ala Pro  Asp Phe Tyr Val Val  Thr Tyr Thr Gly Asp  Lys Glu Ser 
    1025                 1030                 1035             


Arg Ser  Val Ile Arg Glu Asn  Glu Phe Ser Phe Glu  Asp Asn Ala 
    1040                 1045                 1050             


Ile Arg  Ser Gly Lys Lys Val  Phe Arg Met Lys Lys  Glu Val Gln 
    1055                 1060                 1065             


Ile Lys  Phe His Val Leu Leu  Thr Ser Tyr Glu Leu  Ile Thr Ile 
    1070                 1075                 1080             


Asp Gln  Ala Ile Leu Gly Ser  Ile Glu Trp Ala Cys  Leu Val Val 
    1085                 1090                 1095             


Asp Glu  Ala His Arg Leu Lys  Asn Asn Gln Ser Lys  Phe Phe Arg 
    1100                 1105                 1110             


Val Leu  Asn Ser Tyr Lys Ile  Asp Tyr Lys Leu Leu  Leu Thr Gly 
    1115                 1120                 1125             


Thr Pro  Leu Gln Asn Asn Leu  Glu Glu Leu Phe His  Leu Leu Asn 
    1130                 1135                 1140             


Phe Leu  Thr Pro Glu Arg Phe  Asn Asn Leu Glu Gly  Phe Leu Glu 
    1145                 1150                 1155             


Glu Phe  Ala Asp Ile Ser Lys  Glu Asp Gln Ile Lys  Lys Leu His 
    1160                 1165                 1170             


Asp Leu  Leu Gly Pro His Met  Leu Arg Arg Leu Lys  Ala Asp Val 
    1175                 1180                 1185             


Phe Lys  Asn Met Pro Ala Lys  Thr Glu Leu Ile Val  Arg Val Glu 
    1190                 1195                 1200             


Leu Ser  Gln Met Gln Lys Lys  Tyr Tyr Lys Phe Ile  Leu Thr Arg 
    1205                 1210                 1215             


Asn Phe  Glu Ala Leu Asn Ser  Lys Gly Gly Gly Asn  Gln Val Ser 
    1220                 1225                 1230             


Leu Leu  Asn Ile Met Met Asp  Leu Lys Lys Cys Cys  Asn His Pro 
    1235                 1240                 1245             


Tyr Leu  Phe Pro Val Ala Ala  Val Glu Ala Pro Val  Leu Pro Asn 
    1250                 1255                 1260             


Gly Ser  Tyr Asp Gly Ser Ser  Leu Val Lys Ser Ser  Gly Lys Leu 
    1265                 1270                 1275             


Met Leu  Leu Gln Lys Met Leu  Lys Lys Leu Arg Asp  Glu Gly His 
    1280                 1285                 1290             


Arg Val  Leu Ile Phe Ser Gln  Met Thr Lys Met Leu  Asp Leu Leu 
    1295                 1300                 1305             


Glu Asp  Phe Leu Glu Tyr Glu  Gly Tyr Lys Tyr Glu  Arg Ile Asp 
    1310                 1315                 1320             


Gly Gly  Ile Thr Gly Gly Leu  Arg Gln Glu Ala Ile  Asp Arg Phe 
    1325                 1330                 1335             


Asn Ala  Pro Gly Ala Gln Gln  Phe Cys Phe Leu Leu  Ser Thr Arg 
    1340                 1345                 1350             


Ala Gly  Gly Leu Gly Ile Asn  Leu Ala Thr Ala Asp  Thr Val Ile 
    1355                 1360                 1365             


Ile Tyr  Asp Ser Asp Trp Asn  Pro His Asn Asp Ile  Gln Ala Phe 
    1370                 1375                 1380             


Ser Arg  Ala His Arg Ile Gly  Gln Asn Lys Lys Val  Met Ile Tyr 
    1385                 1390                 1395             


Arg Phe  Val Thr Arg Ala Ser  Val Glu Glu Arg Ile  Thr Gln Val 
    1400                 1405                 1410             


Ala Lys  Arg Lys Met Met Leu  Thr His Leu Val Val  Arg Pro Gly 
    1415                 1420                 1425             


Leu Gly  Ser Lys Ser Gly Ser  Met Thr Lys Gln Glu  Leu Asp Asp 
    1430                 1435                 1440             


Ile Leu  Lys Phe Gly Thr Glu  Glu Leu Phe Lys Asp  Asp Val Glu 
    1445                 1450                 1455             


Gly Met  Met Ser Gln Gly Gln  Arg Pro Val Thr Pro  Ile Pro Asp 
    1460                 1465                 1470             


Val Gln  Ser Ser Lys Gly Gly  Asn Leu Ala Ala Ser  Ala Lys Lys 
    1475                 1480                 1485             


Lys His  Gly Ser Thr Pro Pro  Gly Asp Asn Lys Asp  Val Glu Asp 
    1490                 1495                 1500             


Ser Ser  Val Ile His Tyr Asp  Asp Ala Ala Ile Ser  Lys Leu Leu 
    1505                 1510                 1515             


Asp Arg  Asn Gln Asp Ala Thr  Asp Asp Thr Glu Leu  Gln Asn Met 
    1520                 1525                 1530             


Asn Glu  Tyr Leu Ser Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg 
    1535                 1540                 1545             


Glu Glu  Asp Gly Val Glu Glu  Val Glu Arg Glu Ile  Ile Lys Gln 
    1550                 1555                 1560             


Glu Glu  Asn Val Asp Pro Asp  Tyr Trp Glu Lys Leu  Leu Arg His 
    1565                 1570                 1575             


His Tyr  Glu Gln Gln Gln Glu  Asp Leu Ala Arg Asn  Leu Gly Lys 
    1580                 1585                 1590             


Gly Lys  Arg Ile Arg Lys Gln  Val Asn Tyr Asn Asp  Ala Ser Gln 
    1595                 1600                 1605             


Glu Asp  Gln Glu Trp Gln Asp  Glu Leu Ser Asp Asn  Gln Ser Glu 
    1610                 1615                 1620             


Tyr Ser  Ile Gly Ser Glu Asp  Glu Asp Glu Asp Phe  Glu Glu Arg 
    1625                 1630                 1635             


Pro Glu  Gly Gln Ser Gly Arg  Arg Gln Ser Arg Arg  Gln Leu Lys 
    1640                 1645                 1650             


Ser Asp  Arg Asp Lys Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly 
    1655                 1660                 1665             


Gly Asn  Ile Glu Val Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala 
    1670                 1675                 1680             


Phe Leu  Asn Ala Ile Met Arg  Trp Gly Met Pro Pro  Gln Asp Ala 
    1685                 1690                 1695             


Phe Asn  Ser His Trp Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu 
    1700                 1705                 1710             


Lys Glu  Phe Arg Ala Tyr Val  Ser Leu Phe Met Arg  His Leu Cys 
    1715                 1720                 1725             


Glu Pro  Gly Ala Asp Gly Ala  Glu Thr Phe Ala Asp  Gly Val Pro 
    1730                 1735                 1740             


Arg Glu  Gly Leu Ser Arg Gln  His Val Leu Thr Arg  Ile Gly Val 
    1745                 1750                 1755             


Met Ser  Leu Val Arg Lys Lys  Val Gln Glu Phe Glu  His Val Asn 
    1760                 1765                 1770             


Gly Lys  Tyr Ser Thr Pro Asp  Leu Ile Pro Glu Gly  Pro Glu Gly 
    1775                 1780                 1785             


Lys Lys  Ser Gly Glu Val Ile  Ser Ser Asp Pro Asn  Thr Pro Val 
    1790                 1795                 1800             


Pro Ala  Ser Pro Ala His Leu  Leu Pro Ala Pro Leu  Gly Leu Pro 
    1805                 1810                 1815             


Asp Lys  Met Glu Ala Gln Leu  Gly Tyr Met Asp Glu  Lys Asp Pro 
    1820                 1825                 1830             


Gly Ala  Gln Lys Pro Arg Gln  Pro Leu Glu Val Gln  Ala Leu Pro 
    1835                 1840                 1845             


Ala Ala  Leu Asp Arg Val Glu  Ser Glu Asp Lys His  Glu Ser Pro 
    1850                 1855                 1860             


Ala Ser  Lys Glu Arg Ala Arg  Glu Glu Arg Pro Glu  Glu Thr Glu 
    1865                 1870                 1875             


Lys Ala  Pro Pro Ser Pro Glu  Gln Leu Pro Arg Glu  Glu Val Leu 
    1880                 1885                 1890             


Pro Glu  Lys Glu Lys Ile Leu  Asp Lys Leu Glu Leu  Ser Leu Ile 
    1895                 1900                 1905             


His Ser  Arg Gly Asp Ser Ser  Glu Leu Arg Pro Asp  Asp Thr Lys 
    1910                 1915                 1920             


Ala Glu  Glu Lys Glu Pro Ile  Glu Thr Gln Gln Asn  Gly Asp Lys 
    1925                 1930                 1935             


Glu Glu  Asp Asp Glu Gly Lys  Lys Glu Asp Lys Lys  Gly Lys Phe 
    1940                 1945                 1950             


Lys Phe  Met Phe Asn Ile Ala  Asp Gly Gly Phe Thr  Glu Leu His 
    1955                 1960                 1965             


Thr Leu  Trp Gln Asn Glu Glu  Arg Ala Ala Val Ser  Ser Gly Lys 
    1970                 1975                 1980             


Ile Tyr  Asp Ile Trp His Arg  Arg His Asp Tyr Trp  Leu Leu Ala 
    1985                 1990                 1995             


Gly Ile  Val Thr His Gly Tyr  Ala Arg Trp Gln Asp  Ile Gln Asn 
    2000                 2005                 2010             


Asp Pro  Arg Tyr Met Ile Leu  Asn Glu Pro Phe Lys  Ser Glu Val 
    2015                 2020                 2025             


His Lys  Gly Asn Tyr Leu Glu  Met Lys Asn Lys Phe  Leu Ala Arg 
    2030                 2035                 2040             


Arg Phe  Lys Leu Leu Glu Gln  Ala Leu Val Ile Glu  Glu Gln Leu 
    2045                 2050                 2055             


Arg Arg  Ala Ala Tyr Leu Asn  Met Thr Gln Asp Pro  Asn His Pro 
    2060                 2065                 2070             


Ala Met  Ala Leu Asn Ala Arg  Leu Ala Glu Val Glu  Cys Leu Ala 
    2075                 2080                 2085             


Glu Ser  His Gln His Leu Ser  Lys Glu Ser Leu Ala  Gly Asn Lys 
    2090                 2095                 2100             


Pro Ala  Asn Ala Val Leu His  Lys Val Leu Asn Gln  Leu Glu Glu 
    2105                 2110                 2115             


Leu Leu  Ser Asp Met Lys Ala  Asp Val Thr Arg Leu  Pro Ser Met 
    2120                 2125                 2130             


Leu Ser  Arg Ile Pro Pro Val  Ala Ala Arg Leu Gln  Met Ser Glu 
    2135                 2140                 2145             


Arg Ser  Ile Leu Ser Arg Leu  Thr Asn Arg Ala Gly  Asp Pro Thr 
    2150                 2155                 2160             


Ile Gln  Gln Gly Ala Phe Gly  Ser Ser Gln Met Tyr  Ser Asn Asn 
    2165                 2170                 2175             


Phe Gly  Pro Asn Phe Arg Gly  Pro Gly Pro Gly Gly  Ile Val Asn 
    2180                 2185                 2190             


Tyr Asn  Gln Met Pro Leu Gly  Pro Tyr Val Thr Asp  Ile Glu Ser 
    2195                 2200                 2205             


Gly Gly  Gly Gly Ser Pro Gly  Arg Arg Arg Arg Arg  Arg Arg Arg 
    2210                 2215                 2220             


Arg Arg  Arg 
    2225     


<210>  112
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Asp Phe Phe 
                245                 250                 255     


Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met Pro Leu Asn Val 
            260                 265                 270         


Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser Val Gln Pro 
        275                 280                 285             


Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln Gln Gln Gln 
    290                 295                 300                 


Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe 
305                 310                 315                 320 


Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg Ser Gly Leu 
                325                 330                 335     


Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu Arg Gly Asp 
            340                 345                 350         


Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln Leu Glu Met 
        355                 360                 365             


Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser Phe Ile Cys 
    370                 375                 380                 


Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile Gln Asp Cys 
385                 390                 395                 400 


Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser Glu Lys Leu 
                405                 410                 415     


Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro Asn Pro Ala 
            420                 425                 430         


Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu Gln Asp Leu 
        435                 440                 445             


Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val Phe Pro Tyr 
    450                 455                 460                 


Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser Gln Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser Thr Glu Ser 
                485                 490                 495     


Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu Glu Thr Pro 
            500                 505                 510         


Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp Glu Glu Glu 
        515                 520                 525             


Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly Lys Arg Ser 
    530                 535                 540                 


Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro Pro His Ser 
545                 550                 555                 560 


Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln His Asn Tyr 
                565                 570                 575     


Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala Lys Arg Val 
            580                 585                 590         


Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn Asn Arg Lys 
        595                 600                 605             


Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val Lys Arg Arg 
    610                 615                 620                 


Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser 
625                 630                 635                 640 


Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn Asn Glu Lys 
                645                 650                 655     


Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile Leu Ser 
            660                 665                 670         


Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg 
        675                 680                 685             


Lys Arg Arg Glu Gln Ala Lys His Lys Ala Glu Gln Leu Arg Asn Ser 
    690                 695                 700                 


Cys Ala Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
705                 710                 715                 720 


Arg Arg Arg Arg Arg Arg 
                725     


<210>  113
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Thr Met Thr 
                245                 250                 255     


Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly Lys Ala Val Phe 
            260                 265                 270         


Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro Ser Pro Met Ser 
        275                 280                 285             


His Gly His Tyr Ser Met His Cys Leu His Ser Ala Gly His Ser Gln 
    290                 295                 300                 


Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser Arg Pro Leu Gly 
305                 310                 315                 320 


Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser Ser Pro Tyr Ile 
                325                 330                 335     


Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu Ala Gln Ser Arg 
            340                 345                 350         


Leu Glu Asp Pro Gly Ala Asp Ser Glu Lys Ser Thr Val Val Glu Gly 
        355                 360                 365             


Gly Glu Val Arg Phe Asn Gly Lys Gly Lys Lys Ile Arg Lys Pro Arg 
    370                 375                 380                 


Thr Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn Arg Arg Phe Gln 
385                 390                 395                 400 


Gln Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu Ala Ala Ala Ser 
                405                 410                 415     


Ala Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Lys Arg 
            420                 425                 430         


Ser Lys Phe Lys Lys Leu Met Lys Gln Gly Gly Ala Ala Leu Glu Gly 
        435                 440                 445             


Ser Ala Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly Ser Pro Pro Val 
    450                 455                 460                 


Pro Pro Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys Gly Ser Gly Gly 
465                 470                 475                 480 


Asn Ala Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Trp Tyr Pro Ser Ala 
                485                 490                 495     


His Gln Glu Ala Met Gln Gln Pro Gln Leu Met Glu Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        515                 520                 525         


<210>  114
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Thr Gly Val 
                245                 250                 255     


Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln Ile Ala Ala Ser 
            260                 265                 270         


Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly Gly Gly Ala Gly 
        275                 280                 285             


Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His Lys Pro Gln Glu 
    290                 295                 300                 


Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser Ser Tyr Tyr Thr 
305                 310                 315                 320 


Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly Gly Ser Pro Tyr 
                325                 330                 335     


Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly Leu Asn Asn Val 
            340                 345                 350         


Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr Thr Ala Ala Tyr 
        355                 360                 365             


Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro Ala Asn Asn Glu 
    370                 375                 380                 


Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile Val Asn Gly Lys 
385                 390                 395                 400 


Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser Ser Phe Gln Leu 
                405                 410                 415     


Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr Leu Ala Leu Pro 
            420                 425                 430         


Glu Arg Ala Glu Ala Ala Ala Ser Ala Gly Leu Thr Gln Thr Gln Val 
        435                 440                 445             


Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys Lys Met Trp Lys 
    450                 455                 460                 


Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala Ser Ala Ser Pro 
465                 470                 475                 480 


Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser Trp Asp Phe Gly 
                485                 490                 495     


Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala Ala Ser Ala Phe 
        515                 520                 525             


Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly Ser Ala Ser His 
    530                 535                 540                 


Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln Thr Pro Gln Pro 
545                 550                 555                 560 


His His His His His His His Gly Gly Gly Gly Ala Pro Val Ser Ala 
                565                 570                 575     


Gly Thr Ile Phe Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg 
            580                 585                 590         


Arg Arg Arg Arg Arg Arg Arg Arg 
        595                 600 


<210>  115
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Met Gln Glu 
                245                 250                 255     


Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile Gln Asn Gly Ser 
            260                 265                 270         


Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu Arg Glu Gly Arg 
        275                 280                 285             


Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala Ala Asp Leu Ala 
    290                 295                 300                 


His Ala Gln Gln Gln Gln Gln Gln Ala Ala Gln Val Ala Arg Gln Ala 
305                 310                 315                 320 


Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly Leu Lys Ser Pro 
                325                 330                 335     


Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro Val Ser Val Ala 
            340                 345                 350         


Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
        355                 360                 365             


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
    370                 375                 380                 


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
385                 390                 395                 400 


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
                405                 410                 415     


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
            420                 425                 430         


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
        435                 440                 445             


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
    450                 455                 460                 


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
465                 470                 475                 480 


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
                485                 490                 495     


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
            500                 505                 510         


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
        515                 520                 525             


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
    530                 535                 540                 


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
545                 550                 555                 560 


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
                565                 570                 575     


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
            580                 585                 590         


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
        595                 600                 605             


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
    610                 615                 620                 


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
625                 630                 635                 640 


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
                645                 650                 655     


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
            660                 665                 670         


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
        675                 680                 685             


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile 
    690                 695                 700                 


Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe 
705                 710                 715                 720 


Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys 
                725                 730                 735     


Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala 
            740                 745                 750         


Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn 
        755                 760                 765             


Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala 
    770                 775                 780                 


Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys 
785                 790                 795                 800 


Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala 
                805                 810                 815     


Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn 
            820                 825                 830         


Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly 
        835                 840                 845             


Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His 
    850                 855                 860                 


Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln 
865                 870                 875                 880 


Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu 
                885                 890                 895     


Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp 
            900                 905                 910         


Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met 
        915                 920                 925             


Glu Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg 
    930                 935                 940                 


Arg Arg Arg Arg Arg 
945                 


<210>  116
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Met Gln Glu 
                245                 250                 255     


Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn Gln Asn Gly Met 
            260                 265                 270         


Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg Asp Gly Arg Ser 
        275                 280                 285             


Ser Gly Asp Thr Ser Ser Glu Ala Ser Thr Ala Glu Ala Leu His Leu 
    290                 295                 300                 


Gln Gln Gln Gln Ala Ala Gln Ala Ala Arg Gln Ala Leu Leu Gln Gln 
305                 310                 315                 320 


Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp Lys Gln Arg Pro 
                325                 330                 335     


Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr 
            340                 345                 350         


Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln 
        355                 360                 365             


Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val Met Leu Gln Gln 
    370                 375                 380                 


Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu His Leu 
385                 390                 395                 400 


Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                405                 410                 415     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            420                 425                 430         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Gly Lys Gln 
        435                 440                 445             


Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Ala Gln 
    450                 455                 460                 


Gln Leu Val Phe Gln Gln Gln Leu Leu His Met Gln Gln Leu Gln Gln 
465                 470                 475                 480 


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Ile Ser Ile Pro 
                485                 490                 495     


Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu Pro Gln Ala Gly Leu 
            500                 505                 510         


Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu Val Thr Gly Val His 
        515                 520                 525             


Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly Leu Asp Leu Thr Thr 
    530                 535                 540                 


Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser Lys Ala Ser Pro 
545                 550                 555                 560 


Pro Ile Thr His His Ser Ile Val Asn Gly Gln Ser Ser Val Leu Ser 
                565                 570                 575     


Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr Gly Ala Ser His Thr 
            580                 585                 590         


Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ser Ile Cys 
        595                 600                 605             


Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn Asn Glu His Ala Leu 
    610                 615                 620                 


Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln 
625                 630                 635                 640 


Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg Leu Gln Ala Met 
                645                 650                 655     


Met Thr His Leu His Met Arg Pro Ser Glu Pro Lys Pro Ser Pro Lys 
            660                 665                 670         


Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser Lys Asn Met Leu Glu 
        675                 680                 685             


Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr Pro Thr Ala Pro 
    690                 695                 700                 


Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr Pro Ala Ser Val 
705                 710                 715                 720 


Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp Lys Tyr Asn Ile 
                725                 730                 735     


Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe Tyr Lys Asn Ala 
            740                 745                 750         


Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Gln Ala Ile 
        755                 760                 765             


Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Ser Trp 
    770                 775                 780                 


Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys 
785                 790                 795                 800 


Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val 
                805                 810                 815     


Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Tyr Gln 
            820                 825                 830         


Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr Leu Val Lys Asn 
        835                 840                 845             


Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn Ala Ser Leu Gln 
    850                 855                 860                 


Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser Asn Pro Gly Leu 
865                 870                 875                 880 


Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val His Glu Asp Leu 
                885                 890                 895     


Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn Ser Ser Pro Gly 
            900                 905                 910         


Cys Ser Pro Gln Pro His Ile His Ser Ile His Val Lys Glu Glu Pro 
        915                 920                 925             


Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu Val Thr Thr Ala 
    930                 935                 940                 


Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile Glu Glu Glu Pro 
945                 950                 955                 960 


Leu Ser Glu Asp Leu Glu Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg 
                965                 970                 975     


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            980                 985     


<210>  117
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Pro Asn Pro 
                245                 250                 255     


Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu Gly Pro Ser Pro 
            260                 265                 270         


Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala Ser Asp Leu Leu 
        275                 280                 285             


Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg Asp Leu Arg Gly 
    290                 295                 300                 


Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met Pro Pro Ser Gln 
305                 310                 315                 320 


Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala Pro Ser Gly Ala 
                325                 330                 335     


Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu Gln Asp Arg Pro 
            340                 345                 350         


His Phe Met His Gln Leu Ser Thr Val Asp Ala His Ala Arg Thr Pro 
        355                 360                 365             


Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met Ile Ser Leu Thr 
    370                 375                 380                 


Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys Ala Arg Pro Gly 
385                 390                 395                 400 


Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val Ser Arg Glu 
                405                 410                 415     


Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala Pro Arg Lys Asp 
            420                 425                 430         


Arg Ser Val Asp Arg Ala Gly Lys Asp Pro Arg Pro Pro Ile Pro Ser 
        435                 440                 445             


Pro Asp Thr Leu Cys Pro Pro Ser Thr Leu Ser Ala Val Pro Gln Ser 
    450                 455                 460                 


Ser Tyr Pro Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu 
465                 470                 475                 480 


Lys Val Phe Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp 
                485                 490                 495     


His Leu Leu Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu 
            500                 505                 510         


Met Val Gln Ser Ala Glu Gln Gln Ala Val Ala Glu Lys Glu Lys Leu 
        515                 520                 525             


Ser Ala Met Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala 
    530                 535                 540                 


Ser Ser Val Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala 
545                 550                 555                 560 


Gly Ser Gln Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala 
                565                 570                 575     


Pro Asp Ser Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly 
            580                 585                 590         


Asn Ser Thr Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe 
        595                 600                 605             


His Asn Met Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala 
    610                 615                 620                 


Ile Leu Glu Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His 
625                 630                 635                 640 


Trp Phe Thr Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp 
                645                 650                 655     


Lys Asn Ala Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg 
            660                 665                 670         


Val Glu Ser Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe 
        675                 680                 685             


Arg Lys Lys Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro 
    690                 695                 700                 


Gly Pro Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
705                 710                 715                 720 


Arg Arg Arg Arg Arg Arg 
                725     


<210>  118
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Tyr Gln Ser 
                245                 250                 255     


Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly Ala Tyr Glu Ala 
            260                 265                 270         


Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala Ala Ser Ser Pro 
        275                 280                 285             


Val Tyr Val Pro Thr Pro Arg Ala Pro Ser Ser Ala Ala Gly Leu Ser 
    290                 295                 300                 


Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly Gly Ala Ser Gly 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro Gly Thr Gln Gln 
                325                 330                 335     


Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly Ala Ala Tyr Thr 
            340                 345                 350         


Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly Thr Thr Gly Ser 
        355                 360                 365             


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu Ala Ala Ala Tyr 
    370                 375                 380                 


Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala Gly Arg Glu Gln 
385                 390                 395                 400 


Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser Pro Tyr Pro Ala 
                405                 410                 415     


Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala Ala Ala Ala Ser 
            420                 425                 430         


Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu Pro Gly Arg Ala 
        435                 440                 445             


Asn Pro Ala Ala Arg His Pro Asn Leu Val Asp Met Phe Asp Asp Phe 
    450                 455                 460                 


Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser Thr Pro Leu 
465                 470                 475                 480 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                485                 490                 495     


Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys Pro Gln Arg 
            500                 505                 510         


Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala Asn Cys Gln 
        515                 520                 525             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    530                 535                 540                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
545                 550                 555                 560 


Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                565                 570                 575     


Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly Ser Glu Ser 
            580                 585                 590         


Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn Ala Thr Thr 
        595                 600                 605             


Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro Gly Leu Ser 
    610                 615                 620                 


Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe Ser Val Ser 
625                 630                 635                 640 


Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu Ser Ala Leu 
                645                 650                 655     


Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln Ser Pro Gln 
            660                 665                 670         


Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu Ala Asp Ser 
        675                 680                 685             


His Gly Asp Ile Ile Thr Ala Glu Ser Gly Gly Gly Gly Ser Pro Gly 
    690                 695                 700                 


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
705                 710                 715 


<210>  119
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Asn Leu Val 
                245                 250                 255     


Gly Ser Tyr Ala His His His His His His His Pro His Pro Ala His 
            260                 265                 270         


Pro Met Leu His Glu Pro Phe Leu Phe Gly Pro Ala Ser Arg Cys His 
        275                 280                 285             


Gln Glu Arg Pro Tyr Phe Gln Ser Trp Leu Leu Ser Pro Ala Asp Ala 
    290                 295                 300                 


Ala Pro Asp Phe Pro Ala Gly Gly Pro Pro Pro Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Thr Ala Tyr Gly Pro Asp Ala Arg Pro Gly Gln Ser Pro Gly Arg 
                325                 330                 335     


Leu Glu Ala Leu Gly Gly Arg Leu Gly Arg Arg Lys Gly Ser Gly Pro 
            340                 345                 350         


Lys Lys Glu Arg Arg Arg Thr Glu Ser Ile Asn Ser Ala Phe Ala Glu 
        355                 360                 365             


Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr Lys Ala Ser Lys 
    370                 375                 380                 


Ala Lys Thr Ala Arg Leu Ala Thr Ser Tyr Ile Ala Tyr Leu Met Asp 
385                 390                 395                 400 


Val Leu Ala Lys Asp Ala Gln Ser Gly Asp Pro Glu Ala Phe Lys Ala 
                405                 410                 415     


Glu Leu Lys Lys Ala Asp Gly Gly Arg Glu Ser Lys Arg Lys Arg Glu 
            420                 425                 430         


Leu Gln Gln His Glu Gly Phe Pro Pro Ala Leu Gly Pro Val Glu Lys 
        435                 440                 445             


Arg Ile Lys Gly Arg Thr Gly Trp Pro Gln Gln Val Trp Ala Leu Glu 
    450                 455                 460                 


Leu Asn Gln Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg 
465                 470                 475                 480 


Arg Arg Arg Arg Arg Arg Arg 
                485         


<210>  120
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Pro Ala Asp 
                245                 250                 255     


Ile Met Glu Lys Asn Ser Ser Ser Pro Val Ala Ala Thr Pro Ala Ser 
            260                 265                 270         


Val Asn Thr Thr Pro Asp Lys Pro Lys Thr Ala Ser Glu His Arg Lys 
        275                 280                 285             


Ser Ser Lys Pro Ile Met Glu Lys Arg Arg Arg Ala Arg Ile Asn Glu 
    290                 295                 300                 


Ser Ala Ser Gln Ala Lys Thr Ala Ile Leu Asp Ala Leu Lys Lys Asp 
305                 310                 315                 320 


Ser Ser Arg His Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met Thr 
                325                 330                 335     


Val Lys His Leu Arg Asn Leu Gln Arg Ala Gln Met Thr Ala Ala Leu 
            340                 345                 350         


Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr Arg Ala Gly Phe Ser Glu 
        355                 360                 365             


Cys Met Asn Glu Val Thr Arg Phe Leu Ser Thr Cys Glu Gly Val Asn 
    370                 375                 380                 


Thr Glu Val Arg Thr Arg Leu Leu Gly His Leu Ala Asn Cys Met Thr 
385                 390                 395                 400 


Gln Ile Asn Ala Met Thr Tyr Pro Gly Gln Pro His Pro Ala Leu Gln 
                405                 410                 415     


Ala Pro Pro Pro Pro Pro Pro Gly Pro Gly Gly Pro Gln His Ala Pro 
            420                 425                 430         


Phe Ala Pro Pro Pro Pro Leu Val Pro Ile Pro Gly Gly Ala Ala Pro 
        435                 440                 445             


Pro Pro Gly Gly Ala Pro Cys Lys Leu Gly Ser Gln Ala Gly Glu Ala 
    450                 455                 460                 


Ala Lys Val Phe Gly Gly Phe Gln Val Val Pro Ala Pro Asp Gly Gln 
465                 470                 475                 480 


Phe Ala Phe Leu Ile Pro Asn Gly Ala Phe Ala His Ser Gly Pro Val 
                485                 490                 495     


Ile Pro Val Tyr Thr Ser Asn Ser Gly Thr Ser Val Gly Pro Asn Ala 
            500                 505                 510         


Val Ser Pro Ser Ser Gly Pro Ser Leu Thr Ala Asp Ser Met Trp Arg 
        515                 520                 525             


Pro Trp Arg Asn Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg 
    530                 535                 540                 


Arg Arg Arg Arg Arg Arg Arg Arg 
545                 550         


<210>  121
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Pro Ser 
                245                 250                 255     


Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys Asn Arg Leu Arg 
            260                 265                 270         


Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile Asn Ser Ser Ala 
        275                 280                 285             


Glu Gln Ala Lys Ala Leu Leu Glu Gln Glu Phe Ala Arg His Gln Pro 
    290                 295                 300                 


Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met Ala Val Ser Tyr 
305                 310                 315                 320 


Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly Pro Lys Ser Leu 
                325                 330                 335     


His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu Gln Glu Ala Val 
            340                 345                 350         


Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln Met Lys Leu Leu 
        355                 360                 365             


Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala Pro Ala Lys Glu 
    370                 375                 380                 


Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu Ser Ala Lys Ala 
385                 390                 395                 400 


Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys Gly Leu Trp Arg 
                405                 410                 415     


Pro Trp Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
            420                 425                 430         


Arg Arg Arg Arg Arg Arg 
        435             


<210>  122
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Gly Asp Met 
                245                 250                 255     


Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu Cys Val Gly Cys 
            260                 265                 270         


Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val Ser Pro Asp Leu 
        275                 280                 285             


Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys Asn Gln Tyr Leu 
    290                 295                 300                 


Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys Lys 
305                 310                 315                 320 


Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala Lys Cys Ser Ile 
                325                 330                 335     


Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg Ser Lys Val Tyr 
            340                 345                 350         


His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg Gln Leu Ile Pro 
        355                 360                 365             


Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe Cys Arg Ala Asp 
    370                 375                 380                 


His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly Asp Pro Leu Ser 
385                 390                 395                 400 


Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala Glu Pro Ile Ser 
                405                 410                 415     


Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys Gln Pro Glu Lys 
            420                 425                 430         


Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr Leu 
        435                 440                 445             


Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys Glu 
    450                 455                 460                 


Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val Trp 
465                 470                 475                 480 


Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser Ile Met Met Lys 
                485                 490                 495     


Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn Ile Gln Gly Met 
            500                 505                 510         


Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg His Asp Gly Gly 
        515                 520                 525             


Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln Pro Pro Trp Lys 
    530                 535                 540                 


Ala Leu Ser Asp Ala Ala Leu Gln Ser Asp Ile Asp Gln Pro Ala Phe 
545                 550                 555                 560 


Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly Ser Asn Ser Thr 
                565                 570                 575     


Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro Asp Thr Pro Asn 
            580                 585                 590         


Ser Met Val Ala Ser Pro Ile Glu Ala Glu Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    610                 615                 620     


<210>  123
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Leu Phe His 
                245                 250                 255     


Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp Glu Met Asp Arg 
            260                 265                 270         


Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala Ile Asp Arg Gly 
        275                 280                 285             


Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp Arg Ala Ala Leu 
    290                 295                 300                 


Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr Tyr Leu Leu Ala 
305                 310                 315                 320 


Val Asp Lys Gln Trp His Ala Arg Cys Ala Lys Cys Cys Glu Cys Lys 
                325                 330                 335     


Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys Asp Gly Ser Ile 
            340                 345                 350         


Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val Gln Arg Cys Ala 
        355                 360                 365             


Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val Met Arg Ala Arg 
    370                 375                 380                 


Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr Thr Cys Asn Lys 
385                 390                 395                 400 


Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp Ser Leu Val Tyr 
                405                 410                 415     


Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu Tyr Pro Ala His 
            420                 425                 430         


Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro Leu Gly Leu Pro 
    450                 455                 460                 


Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg Pro Arg Lys Arg 
465                 470                 475                 480 


Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr Asn Ala Ala Leu 
                485                 490                 495     


Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg Asp Gln Pro Tyr 
            500                 505                 510         


Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser Phe Lys His His 
        515                 520                 525             


Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn His Asn Pro Asp 
    530                 535                 540                 


Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly Leu Thr Lys Arg 
545                 550                 555                 560 


Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys Phe Arg Arg Asn 
                565                 570                 575     


Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser Thr Asp Ala Ala 
            580                 585                 590         


Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu Leu Ser Asn Ala 
        595                 600                 605             


Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr Asp Leu Thr Ser 
    610                 615                 620                 


Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser Val Pro Gly Asn 
625                 630                 635                 640 


Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr Thr Leu Thr Asn 
                645                 650                 655     


Leu Phe Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
            660                 665                 670         


Arg Arg Arg Arg Arg Arg 
        675             


<210>  124
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Arg Gln Pro 
                245                 250                 255     


Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe 
            260                 265                 270         


Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln 
        275                 280                 285             


Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu Ser His Met Lys 
    290                 295                 300                 


Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp Leu Ala Ala Ala 
305                 310                 315                 320 


Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly Ala Ala Cys Gly 
                325                 330                 335     


Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr Glu Glu Phe Asn 
            340                 345                 350         


Asp Ala Ala Asp Leu Asp Ala Ile Leu Ser Asn Ser Leu Thr His Pro 
        355                 360                 365             


Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala Ser Ala Ser Ser 
    370                 375                 380                 


Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala Pro Ser Thr Cys 
385                 390                 395                 400 


Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro Gly Val Ala Pro 
                405                 410                 415     


Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu Ser Ala Pro Pro 
            420                 425                 430         


Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp Val Ser Pro Ser 
        435                 440                 445             


Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu Asp Pro Val Tyr 
    450                 455                 460                 


Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly Leu Met Gly Lys 
465                 470                 475                 480 


Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser Glu Tyr Gly Ser 
                485                 490                 495     


Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp Gly Ser His Pro 
            500                 505                 510         


Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg Thr Cys Pro Lys 
        515                 520                 525             


Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu Gly Ala Gly Pro 
    530                 535                 540                 


Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp Phe Pro Leu Gly 
545                 550                 555                 560 


Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly Leu Glu Glu Val 
                565                 570                 575     


Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu Pro Pro Gly Phe 
            580                 585                 590         


His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu Pro Asp Gln Met 
        595                 600                 605             


Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu Met Pro Pro Gly 
    610                 615                 620                 


Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly Arg Arg Ser Trp 
625                 630                 635                 640 


Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr Ala Gly Cys Gly 
                645                 650                 655     


Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His 
            660                 665                 670         


Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys 
        675                 680                 685             


Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly 
    690                 695                 700                 


His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala Phe Ser Arg Ser 
705                 710                 715                 720 


Asp His Leu Ala Leu His Met Lys Arg His Phe Glu Ser Gly Gly Gly 
                725                 730                 735     


Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            740                 745                 750     


<210>  125
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Ala Glu 
                245                 250                 255     


Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu Ala Ile Glu Tyr 
            260                 265                 270         


Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys Lys Glu Pro Pro 
        275                 280                 285             


Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly Ser Leu Ser Ser 
    290                 295                 300                 


Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser Ser Pro Ser Phe 
305                 310                 315                 320 


Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly Ala Gly Gly Gly 
                325                 330                 335     


Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro Pro Ser Gly Gly 
            340                 345                 350         


Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala Leu Glu Asp Leu 
        355                 360                 365             


Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro Glu Ala Leu Asn 
    370                 375                 380                 


Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly Ser Gly His His 
385                 390                 395                 400 


Gly Ala His His Gly Ala His His Pro Ala Ala Ala Ala Ala Tyr Glu 
                405                 410                 415     


Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly Ala Asp Asp Met 
            420                 425                 430         


Gly Ala Gly His His His Gly Ala His His Ala Ala His His His His 
        435                 440                 445             


Ala Ala His His His His His His His His His His Gly Gly Ala Gly 
    450                 455                 460                 


His Gly Gly Gly Ala Gly His His Val Arg Leu Glu Glu Arg Phe Ser 
465                 470                 475                 480 


Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu Asn Arg Gln Leu 
                485                 490                 495     


Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys Gln Lys Arg Arg 
            500                 505                 510         


Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg Phe Lys Arg Val 
        515                 520                 525             


Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln Leu Gln Ser Gln 
    530                 535                 540                 


Ala Glu Gln Ala Lys Leu Glu Val Gly Arg Leu Ala Lys Glu Arg Asp 
545                 550                 555                 560 


Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg Gly Gly Pro Gly 
                565                 570                 575     


Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser Pro Pro Gln Ala 
            580                 585                 590         


Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe Leu Glu Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    610                 615                 620                 


Arg 
625 


<210>  126
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Gly Arg Lys 
                245                 250                 255     


Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn Arg Gln Val Thr 
            260                 265                 270         


Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala Tyr Glu Ala Ser 
        275                 280                 285             


Val Ala Cys Asp Cys Glu Ala Ala Leu Ile Ile Phe Asn Ser Thr Asn 
    290                 295                 300                 


Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys Val Leu Leu Lys 
305                 310                 315                 320 


Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr Asn Ser Asp Ile 
                325                 330                 335     


Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys Asp Ser Pro Asp 
            340                 345                 350         


Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu Ser Glu Asp Lys 
        355                 360                 365             


Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile Ser Arg Gln Arg 
    370                 375                 380                 


Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser Ile Pro 
385                 390                 395                 400 


Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser Ser Leu 
                405                 410                 415     


Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln Arg Asn 
            420                 425                 430         


Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly Asn Thr 
        435                 440                 445             


Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr Ser Ala 
    450                 455                 460                 


Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu Val Ser 
465                 470                 475                 480 


Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro Pro Met 
                485                 490                 495     


Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu Ile Pro 
            500                 505                 510         


Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu Asp Val Asp Leu 
        515                 520                 525             


Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala 
    530                 535                 540                 


Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro Gly Gln Gly Met 
545                 550                 555                 560 


Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser 
                565                 570                 575     


Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser 
            580                 585                 590         


Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln Gln His Leu His 
        595                 600                 605             


Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr 
    610                 615                 620                 


His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu 
625                 630                 635                 640 


Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp Arg Thr Thr Thr 
                645                 650                 655     


Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala Gly Arg Ser Pro 
            660                 665                 670         


Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg 
        675                 680                 685             


Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly Leu Thr Arg Pro 
    690                 695                 700                 


Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg Met Arg Leu Ser 
705                 710                 715                 720 


Glu Gly Trp Ala Thr Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg 
                725                 730                 735     


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            740                 745 


<210>  127
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Gln Pro 
                245                 250                 255     


Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser Ala Ala Trp Gly 
            260                 265                 270         


Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys Gly Arg Ser Leu 
        275                 280                 285             


Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala Asp Ser Pro Val 
    290                 295                 300                 


Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro Arg Ala Pro Ser 
305                 310                 315                 320 


Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly Ser Gly Gln Arg 
                325                 330                 335     


Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg Thr Leu Ala Arg 
            340                 345                 350         


Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser Val Ala Pro Ala 
        355                 360                 365             


Gly Gln Ser Leu Thr Lys Ala Glu Thr Ala Arg Leu Ala Ile Arg Tyr 
    370                 375                 380                 


Ala Gly His Ala Ser Ala Val Leu Gly Leu Ser Glu Glu Ser Leu Gln 
385                 390                 395                 400 


Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro Arg Gly Cys Pro 
                405                 410                 415     


Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr Arg Thr Gln Ala 
            420                 425                 430         


Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val Ser Ala Val Arg 
        435                 440                 445             


Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro Gly Ala Arg Ala 
    450                 455                 460                 


Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala Glu Ala Ala Cys 
465                 470                 475                 480 


Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser Pro Leu Leu Pro 
                485                 490                 495     


Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro Leu Ser Pro Leu 
            500                 505                 510         


Glu Trp Leu Pro Glu Glu Pro Lys Glu Ser Gly Gly Gly Gly Ser Pro 
        515                 520                 525             


Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    530                 535                 540 


<210>  128
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Lys Lys Lys Arg 
                245                 250                 255     


Lys Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His 
            260                 265                 270         


Met Glu Ala Ala Ser Pro Pro Ala Arg Asp Val Asp Leu Thr Ala Pro 
        275                 280                 285             


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
    290                 295                 300                 


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
305                 310                 315                 320 


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
                325                 330                 335     


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
            340                 345                 350         


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
        355                 360                 365             


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
    370                 375                 380                 


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
385                 390                 395                 400 


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
                405                 410                 415     


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
            420                 425                 430         


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
        435                 440                 445             


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
    450                 455                 460                 


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
465                 470                 475                 480 


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
                485                 490                 495     


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
            500                 505                 510         


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
        515                 520                 525             


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
    530                 535                 540                 


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
545                 550                 555                 560 


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
                565                 570                 575     


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
            580                 585                 590         


Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg 
        595                 600                 605             


Arg Arg Arg Arg 
    610         


<210>  129
<211>  1456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Val Asp 
                245                 250                 255     


Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly Val Arg Val Pro 
            260                 265                 270         


Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro Thr Pro Gly Cys 
        275                 280                 285             


Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg His Arg Ser Val 
    290                 295                 300                 


Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln Asp Lys Gln Pro 
305                 310                 315                 320 


Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val Lys Ala Asp Ser 
                325                 330                 335     


Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr Glu Asp Met Asp 
            340                 345                 350         


Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu Asp Asn Asp Glu 
        355                 360                 365             


Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp Arg Glu Glu Glu 
    370                 375                 380                 


Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu Asp Gly Glu Asp 
385                 390                 395                 400 


Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His Asn Thr Arg Ile 
            420                 425                 430         


Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp Glu Tyr Asp Asn 
        435                 440                 445             


Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu Gly Lys Ile Ala 
    450                 455                 460                 


Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu Met Asn Ser Asn 
465                 470                 475                 480 


Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn Glu Asn Leu Gly 
                485                 490                 495     


Arg Lys Ser Glu Ala Ser Ala Asp Leu Asp Ser Asp Val Val Arg Glu 
            500                 505                 510         


Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His Gly Val Val Leu 
        515                 520                 525             


Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser Met Ser Gln Gln 
    530                 535                 540                 


Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys Pro Met Asn Asn 
545                 550                 555                 560 


Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu Glu Val Cys Leu 
                565                 570                 575     


Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp Leu Ala Arg Lys 
            580                 585                 590         


Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln Gln Asn Met Asn 
        595                 600                 605             


Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro Gly Arg Thr Pro 
    610                 615                 620                 


Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg Leu Glu Glu Gln 
625                 630                 635                 640 


Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala Lys Glu Asp Gly 
                645                 650                 655     


Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn Ser Asp Arg Ser 
            660                 665                 670         


Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr Leu Leu Glu Lys 
        675                 680                 685             


Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met Arg Glu Lys Met 
    690                 695                 700                 


Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser Tyr Glu Asp Gln 
705                 710                 715                 720 


Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro Lys Ser Ser Asp 
                725                 730                 735     


Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg Thr Glu Lys Lys 
            740                 745                 750         


Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr Gly His Val Thr 
        755                 760                 765             


Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys Pro His Lys Asp 
    770                 775                 780                 


Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser Val Leu Lys Cys 
785                 790                 795                 800 


Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn Ser Asn Arg Asn 
                805                 810                 815     


Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala Ala Glu Lys Leu 
            820                 825                 830         


Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val Ser Lys Ser Ser 
        835                 840                 845             


Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe Val Lys Gln Leu 
    850                 855                 860                 


Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro Thr Thr Thr Pro 
865                 870                 875                 880 


Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser Lys Thr Ser Phe 
                885                 890                 895     


Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys Arg Ala Ile Ala 
            900                 905                 910         


Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly Tyr Asp Asp Ala 
        915                 920                 925             


Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser Ser Thr Ser Ser 
    930                 935                 940                 


Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly Gly Gly Ser Ser 
945                 950                 955                 960 


Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr Thr His Asp Met 
                965                 970                 975     


Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn Leu Ser Thr Arg 
            980                 985                 990         


Cys Arg Glu Met Pro Gln Asn Leu  Ser Thr Lys Pro Gln  Asp Leu Cys 
        995                 1000                 1005             


Ala Thr  Arg Asn Pro Asp Met  Glu Val Asp Glu Asn  Gly Thr Leu 
    1010                 1015                 1020             


Asp Leu  Ser Met Asn Lys Gln  Arg Pro Arg Asp Ser  Cys Cys Pro 
    1025                 1030                 1035             


Ile Leu  Thr Pro Leu Glu Pro  Met Ser Pro Gln Gln  Gln Ala Val 
    1040                 1045                 1050             


Met Asn  Asn Arg Cys Phe Gln  Leu Gly Glu Gly Asp  Cys Trp Asp 
    1055                 1060                 1065             


Leu Pro  Val Asp Tyr Thr Lys  Met Lys Pro Arg Arg  Ile Asp Glu 
    1070                 1075                 1080             


Asp Glu  Ser Lys Asp Ile Thr  Pro Glu Asp Leu Asp  Pro Phe Gln 
    1085                 1090                 1095             


Glu Ala  Leu Glu Glu Arg Arg  Tyr Pro Gly Glu Val  Thr Ile Pro 
    1100                 1105                 1110             


Ser Pro  Lys Pro Lys Tyr Pro  Gln Cys Lys Glu Ser  Lys Lys Asp 
    1115                 1120                 1125             


Leu Ile  Thr Leu Ser Gly Cys  Pro Leu Ala Asp Lys  Ser Ile Arg 
    1130                 1135                 1140             


Ser Met  Leu Ala Thr Ser Ser  Gln Glu Leu Lys Cys  Pro Thr Pro 
    1145                 1150                 1155             


Gly Cys  Asp Gly Ser Gly His  Ile Thr Gly Asn Tyr  Ala Ser His 
    1160                 1165                 1170             


Arg Ser  Leu Ser Gly Cys Pro  Arg Ala Lys Lys Ser  Gly Ile Arg 
    1175                 1180                 1185             


Ile Ala  Gln Ser Lys Glu Asp  Lys Glu Asp Gln Glu  Pro Ile Arg 
    1190                 1195                 1200             


Cys Pro  Val Pro Gly Cys Asp  Gly Gln Gly His Ile  Thr Gly Lys 
    1205                 1210                 1215             


Tyr Ala  Ser His Arg Ser Ala  Ser Gly Cys Pro Leu  Ala Ala Lys 
    1220                 1225                 1230             


Arg Gln  Lys Asp Gly Tyr Leu  Asn Gly Ser Gln Phe  Ser Trp Lys 
    1235                 1240                 1245             


Ser Val  Lys Thr Glu Gly Met  Ser Cys Pro Thr Pro  Gly Cys Asp 
    1250                 1255                 1260             


Gly Ser  Gly His Val Ser Gly  Ser Phe Leu Thr His  Arg Ser Leu 
    1265                 1270                 1275             


Ser Gly  Cys Pro Arg Ala Thr  Ser Ala Met Lys Lys  Ala Lys Leu 
    1280                 1285                 1290             


Ser Gly  Glu Gln Met Leu Thr  Ile Lys Gln Arg Ala  Ser Asn Gly 
    1295                 1300                 1305             


Ile Glu  Asn Asp Glu Glu Ile  Lys Gln Leu Asp Glu  Glu Ile Lys 
    1310                 1315                 1320             


Glu Leu  Asn Glu Ser Asn Ser  Gln Met Glu Ala Asp  Met Ile Lys 
    1325                 1330                 1335             


Leu Arg  Thr Gln Ile Thr Thr  Met Glu Ser Asn Leu  Lys Thr Ile 
    1340                 1345                 1350             


Glu Glu  Glu Asn Lys Val Ile  Glu Gln Gln Asn Glu  Ser Leu Leu 
    1355                 1360                 1365             


His Glu  Leu Ala Asn Leu Ser  Gln Ser Leu Ile His  Ser Leu Ala 
    1370                 1375                 1380             


Asn Ile  Gln Leu Pro His Met  Asp Pro Ile Asn Glu  Gln Asn Phe 
    1385                 1390                 1395             


Asp Ala  Tyr Val Thr Thr Leu  Thr Glu Met Tyr Thr  Asn Gln Asp 
    1400                 1405                 1410             


Arg Tyr  Gln Ser Pro Glu Asn  Lys Ala Leu Leu Glu  Asn Ile Lys 
    1415                 1420                 1425             


Gln Ala  Val Arg Gly Ile Gln  Val Glu Ser Gly Gly  Gly Gly Ser 
    1430                 1435                 1440             


Pro Gly  Arg Arg Arg Arg Arg  Arg Arg Arg Arg Arg  Arg 
    1445                 1450                 1455     


<210>  130
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ser Val Asp 
                245                 250                 255     


Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala Ser Asp Cys Lys 
            260                 265                 270         


Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu Glu Asn Tyr Pro 
        275                 280                 285             


Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr Glu Thr Val Ser 
    290                 295                 300                 


Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp Ser Pro Asp Ser 
305                 310                 315                 320 


Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala Glu Lys Ser Val 
                325                 330                 335     


Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln Lys Thr Arg Thr 
            340                 345                 350         


Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp Arg Phe Gln Arg 
        355                 360                 365             


Gln Lys Tyr Leu Ser Leu Gln Gln Ala Gln Glu Ala Ser Asn Ile Leu 
    370                 375                 380                 


Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln Asn Gln Arg Met 
385                 390                 395                 400 


Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys Asn Ser Asn Gly 
                405                 410                 415     


Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser Leu Tyr Ser Ser 
            420                 425                 430         


Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn Leu Pro Met Trp 
        435                 440                 445             


Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn Gln Thr Gln Asn 
    450                 455                 460                 


Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln Thr Trp Cys Thr 
465                 470                 475                 480 


Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe Tyr Asn Cys Gly 
                485                 490                 495     


Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro Asn Ser Pro Ala 
            500                 505                 510         


Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu Gly Leu Asn Val 
        515                 520                 525             


Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln Thr Met Asp Leu 
    530                 535                 540                 


Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp Val Glu Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
                565                 570                 575     


Arg 
    


<210>  131
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Glu Ser 
                245                 250                 255     


Glu Asn Arg Lys Glu Leu Ser Glu Ser Ser Gln Glu Glu Ala Gly Asn 
            260                 265                 270         


Gln Ile Met Val Glu Gly Leu Gly Glu His Leu Glu Arg Gly Glu Asp 
        275                 280                 285             


Ala Ala Ala Gly Leu Gly Asp Asp Gly Lys Cys Gly Glu Glu Ala Ala 
    290                 295                 300                 


Ala Gly Leu Gly Glu Glu Gly Glu Asn Gly Glu Asp Thr Ala Ala Gly 
305                 310                 315                 320 


Ser Gly Glu Asp Gly Lys Lys Gly Gly Asp Thr Asp Glu Asp Ser Glu 
                325                 330                 335     


Ala Asp Arg Pro Lys Gly Leu Ile Gly Tyr Val Leu Asp Thr Asp Phe 
            340                 345                 350         


Val Glu Ser Leu Pro Val Lys Val Lys Tyr Arg Val Leu Ala Leu Lys 
        355                 360                 365             


Lys Leu Gln Thr Arg Ala Ala Asn Leu Glu Ser Lys Phe Leu Arg Glu 
    370                 375                 380                 


Phe His Asp Ile Glu Arg Lys Phe Ala Glu Met Tyr Gln Pro Leu Leu 
385                 390                 395                 400 


Glu Lys Arg Arg Gln Ile Ile Asn Ala Ile Tyr Glu Pro Thr Glu Glu 
                405                 410                 415     


Glu Cys Glu Tyr Lys Ser Asp Ser Glu Asp Cys Asp Asp Glu Glu Met 
            420                 425                 430         


Cys His Glu Glu Met Tyr Gly Asn Glu Glu Gly Met Val His Glu Tyr 
        435                 440                 445             


Val Asp Glu Asp Asp Gly Tyr Glu Asp Tyr Tyr Tyr Asp Tyr Ala Val 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ile Glu Ala Thr Gly 
465                 470                 475                 480 


Glu Glu Asn Lys Glu Glu Glu Asp Pro Lys Gly Ile Pro Asp Phe Trp 
                485                 490                 495     


Leu Thr Val Leu Lys Asn Val Asp Thr Leu Thr Pro Leu Ile Lys Lys 
            500                 505                 510         


Tyr Asp Glu Pro Ile Leu Lys Ala Leu Thr Asp Ala Lys Val Lys Leu 
        515                 520                 525             


Ser Asp Pro Gly Glu Pro Leu Ser Phe Thr Leu Glu Phe His Phe Lys 
    530                 535                 540                 


Pro Asn Glu Tyr Phe Lys Asn Glu Leu Leu Thr Lys Thr Tyr Val Leu 
545                 550                 555                 560 


Lys Ser Lys Leu Ala Tyr Tyr Asp Pro His Pro Tyr Arg Gly Thr Ala 
                565                 570                 575     


Ile Glu Tyr Ser Thr Gly Cys Glu Ile Asp Trp Asn Glu Gly Lys Asn 
            580                 585                 590         


Val Thr Leu Lys Thr Ile Lys Lys Lys Gln Lys His Arg Ile Trp Gly 
        595                 600                 605             


Thr Ile Arg Thr Val Thr Glu Asp Phe Pro Lys Asp Ser Phe Phe Asn 
    610                 615                 620                 


Phe Phe Ser Pro His Gly Ile Thr Ser Asn Gly Arg Asp Gly Asn Asp 
625                 630                 635                 640 


Asp Phe Leu Leu Gly His Asn Leu Arg Thr Tyr Ile Ile Pro Arg Ser 
                645                 650                 655     


Val Leu Phe Phe Ser Gly Asp Ala Leu Glu Ser Gln Gln Glu Gly Val 
            660                 665                 670         


Val Arg Glu Val Asn Asp Ala Ile Tyr Asp Lys Ile Ile Tyr Asp Asn 
        675                 680                 685             


Trp Met Ala Ala Ile Glu Glu Val Lys Ala Cys Cys Lys Asn Leu Glu 
    690                 695                 700                 


Ala Leu Val Glu Asp Ile Asp Arg Glu Ser Gly Gly Gly Gly Ser Pro 
705                 710                 715                 720 


Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
                725                 730         


<210>  132
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Thr Lys Ser 
                245                 250                 255     


Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro Gln Gly Pro Pro 
            260                 265                 270         


Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu Glu His Glu Ala 
        275                 280                 285             


Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala Glu Glu Asp Ser 
    290                 295                 300                 


Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu Asp Leu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys Pro Lys Arg Arg 
                325                 330                 335     


Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu Glu Arg Phe Lys 
            340                 345                 350         


Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn Arg Met His Gly 
        355                 360                 365             


Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val Pro Cys Tyr Ser 
    370                 375                 380                 


Lys Thr Gln Lys Ala Ser Lys Ala Glu Thr Leu Arg Leu Ala Lys Asn 
385                 390                 395                 400 


Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly Lys Ser Pro Asp 
                405                 410                 415     


Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu Ser Gln Pro Thr 
            420                 425                 430         


Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro Arg Thr Phe Leu 
        435                 440                 445             


Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro Thr Ala Ser Ala 
    450                 455                 460                 


Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro Gly Leu Pro Ser 
465                 470                 475                 480 


Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe His Val Lys Pro 
                485                 490                 495     


Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe Phe Glu Ser Pro 
            500                 505                 510         


Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro Leu Ser Pro Pro 
        515                 520                 525             


Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu Pro Ser Ala Glu 
    530                 535                 540                 


Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro Ala Ala Thr Leu 
545                 550                 555                 560 


Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly Thr Ala Ala Pro 
                565                 570                 575     


Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe Asp Ser His Ser 
            580                 585                 590         


His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala Ile Phe His Asp 
        595                 600                 605             


Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg 
    610                 615                 620                 


Arg Arg Arg Arg 
625             


<210>  133
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Leu Thr Arg 
                245                 250                 255     


Leu Phe Ser Glu Pro Gly Leu Leu Ser Asp Val Pro Lys Phe Ala Ser 
            260                 265                 270         


Trp Gly Asp Gly Glu Asp Asp Glu Pro Arg Ser Asp Lys Gly Asp Ala 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Ala Pro Gly Pro Gly Ala Pro Gly Pro Ala 
    290                 295                 300                 


Arg Ala Ala Lys Pro Val Pro Leu Arg Gly Glu Glu Gly Thr Glu Ala 
305                 310                 315                 320 


Thr Leu Ala Glu Val Lys Glu Glu Gly Glu Leu Gly Gly Glu Glu Glu 
                325                 330                 335     


Glu Glu Glu Glu Glu Glu Glu Gly Leu Asp Glu Ala Glu Gly Glu Arg 
            340                 345                 350         


Pro Lys Lys Arg Gly Pro Lys Lys Arg Lys Met Thr Lys Ala Arg Leu 
        355                 360                 365             


Glu Arg Ser Lys Leu Arg Arg Gln Lys Ala Asn Ala Arg Glu Arg Asn 
    370                 375                 380                 


Arg Met His Asp Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
385                 390                 395                 400 


Pro Cys Tyr Ser Lys Thr Gln Lys Ala Ser Lys Ala Glu Thr Leu Arg 
                405                 410                 415     


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
            420                 425                 430         


Lys Arg Pro Asp Leu Val Ser Tyr Val Gln Thr Leu Cys Lys Gly Leu 
        435                 440                 445             


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Ser 
    450                 455                 460                 


Arg Asn Phe Leu Thr Glu Gln Gly Ala Asp Gly Ala Gly Arg Phe His 
465                 470                 475                 480 


Gly Ser Gly Gly Pro Phe Ala Met His Pro Tyr Pro Tyr Pro Cys Ser 
                485                 490                 495     


Arg Leu Ala Gly Ala Gln Cys Gln Ala Ala Gly Gly Leu Gly Gly Gly 
            500                 505                 510         


Ala Ala His Ala Leu Arg Thr His Gly Tyr Cys Ala Ala Tyr Glu Thr 
        515                 520                 525             


Leu Tyr Ala Ala Ala Gly Gly Gly Gly Ala Ser Pro Asp Tyr Asn Ser 
    530                 535                 540                 


Ser Glu Tyr Glu Gly Pro Leu Ser Pro Pro Leu Cys Leu Asn Gly Asn 
545                 550                 555                 560 


Phe Ser Leu Lys Gln Asp Ser Ser Pro Asp His Glu Lys Ser Tyr His 
                565                 570                 575     


Tyr Ser Met His Tyr Ser Ala Leu Pro Gly Ser Arg Pro Thr Gly His 
            580                 585                 590         


Gly Leu Val Phe Gly Ser Ser Ala Val Arg Gly Gly Val His Ser Glu 
        595                 600                 605             


Asn Leu Leu Ser Tyr Asp Met His Leu His His Asp Arg Gly Pro Met 
    610                 615                 620                 


Tyr Glu Glu Leu Asn Ala Phe Phe His Asn Glu Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
                645                 650                 


<210>  134
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Phe Val Lys 
                245                 250                 255     


Ser Glu Thr Ala Glu Ala Lys Glu Glu Glu Asp Val Leu Val Leu Leu 
            260                 265                 270         


Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro Leu Ser Ser Ser 
        275                 280                 285             


Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser Gly Gly Ala Arg 
    290                 295                 300                 


Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg Gly Gly Val Ala 
305                 310                 315                 320 


Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu Gly Leu Val His 
                325                 330                 335     


Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val Ser Arg Gly Ala 
            340                 345                 350         


Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr Arg Arg Leu Lys 
        355                 360                 365             


Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu Asn Ala Ala Leu 
    370                 375                 380                 


Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu Asp Ala Lys Leu 
385                 390                 395                 400 


Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr Ile Trp Ala Leu 
                405                 410                 415     


Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly Gly Gly Gly Gly 
            420                 425                 430         


Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu Ser Pro Gly Gly 
        435                 440                 445             


Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro Ser Pro Ala Ser 
    450                 455                 460                 


Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser Ser Val Ser Ser 
465                 470                 475                 480 


Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro Ala Ser Pro Ala 
                485                 490                 495     


Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro Asp Lys His Arg 
            500                 505                 510         


Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile Glu Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    530                 535                 540                 


<210>  135
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Thr Pro Gln 
                245                 250                 255     


Pro Ser Gly Ala Pro Thr Val Gln Val Thr Arg Glu Thr Glu Arg Ser 
            260                 265                 270         


Phe Pro Arg Ala Ser Glu Asp Glu Val Thr Cys Pro Thr Ser Ala Pro 
        275                 280                 285             


Pro Ser Pro Thr Arg Thr Arg Gly Asn Cys Ala Glu Ala Glu Glu Gly 
    290                 295                 300                 


Gly Cys Arg Gly Ala Pro Arg Lys Leu Arg Ala Arg Arg Gly Gly Arg 
305                 310                 315                 320 


Ser Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln Arg Arg Ser Arg 
                325                 330                 335     


Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met His Asn Leu Asn 
            340                 345                 350         


Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr Phe Pro Asp Asp 
        355                 360                 365             


Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr Ile 
    370                 375                 380                 


Trp Ala Ala Thr Gln Thr Ala Arg Ile Ala Asp His Ser Leu Tyr Ala 
385                 390                 395                 400 


Leu Glu Pro Pro Ala Pro His Cys Gly Glu Leu Gly Ser Pro Gly Gly 
                405                 410                 415     


Ser Pro Gly Asp Trp Gly Ser Leu Tyr Ser Pro Val Ser Gln Ala Gly 
            420                 425                 430         


Ser Leu Ser Pro Ala Ala Ser Leu Glu Glu Arg Pro Gly Leu Leu Gly 
        435                 440                 445             


Ala Thr Phe Ser Ala Cys Leu Ser Pro Gly Ser Leu Ala Phe Ser Asp 
    450                 455                 460                 


Phe Leu Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
465                 470                 475                 480 


Arg Arg Arg Arg Arg Arg 
                485     


<210>  136
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Met Leu Ser 
                245                 250                 255     


Pro Asp Gln Ala Ala Asp Ser Asp His Pro Ser Ser Ala His Ser Asp 
            260                 265                 270         


Pro Glu Ser Leu Gly Gly Thr Asp Thr Lys Val Leu Gly Ser Val Ser 
        275                 280                 285             


Asp Leu Glu Pro Val Glu Glu Ala Glu Gly Asp Gly Lys Gly Gly Ser 
    290                 295                 300                 


Arg Ala Ala Leu Tyr Pro His Pro Gln Gln Leu Ser Arg Glu Glu Lys 
305                 310                 315                 320 


Arg Arg Arg Arg Arg Ala Thr Ala Lys Tyr Arg Ser Ala His Ala Thr 
                325                 330                 335     


Arg Glu Arg Ile Arg Val Glu Ala Phe Asn Leu Ala Phe Ala Glu Leu 
            340                 345                 350         


Arg Lys Leu Leu Pro Thr Leu Pro Pro Asp Lys Lys Ala Ser Lys Ala 
        355                 360                 365             


Glu Ile Leu Arg Leu Ala Ile Cys Tyr Ile Ser Tyr Leu Asn His Val 
    370                 375                 380                 


Leu Asp Val Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg 
385                 390                 395                 400 


Arg Arg Arg Arg Arg Arg Arg 
                405         


<210>  137
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ser Leu Thr 
                245                 250                 255     


Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu Asp Leu Pro Asp 
            260                 265                 270         


Thr Asn Asp Glu Glu Gly Ser Val Ala Glu Gly Pro Glu Glu Glu Asn 
        275                 280                 285             


Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu Gly Gln Gly Ala 
    290                 295                 300                 


Ala Asp Ala Ala Gln Ser Leu Pro Leu Lys Asn Pro Phe Tyr Asp Ser 
305                 310                 315                 320 


Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr Glu Gly Leu Gln 
                325                 330                 335     


Tyr Ser Leu His Gly Leu Ala Ala Gly Ala Pro Pro Gln Asp Ser Ser 
            340                 345                 350         


Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro Asp Asn Asp Lys 
        355                 360                 365             


Glu Thr Pro Gly Gly Gly Gly Asp Ala Gly Lys Lys Arg Lys Arg Arg 
    370                 375                 380                 


Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu Arg Arg Phe Arg 
385                 390                 395                 400 


Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His Leu Ala Ser Leu 
                405                 410                 415     


Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe Gln Asn His Arg 
            420                 425                 430         


Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met Glu Val Thr Pro 
        435                 440                 445             


Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu Val Arg Asp Gly 
    450                 455                 460                 


Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala Ala Ala Thr Phe 
465                 470                 475                 480 


Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln Ser Leu Gln His 
                485                 490                 495     


Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr Pro Gln Tyr Pro 
            500                 505                 510         


Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr Trp Glu Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    530                 535                 540                 


Arg 
545 


<210>  138
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Phe Pro Ser 
                245                 250                 255     


Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp Ile Leu Asn Leu 
            260                 265                 270         


Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu Leu Ser Ala Arg 
        275                 280                 285             


Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu Ala Ala Phe Lys 
    290                 295                 300                 


Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro Gly Leu Pro Glu 
305                 310                 315                 320 


Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala Lys Cys Ala Ser 
                325                 330                 335     


Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala Tyr Ser Asp Pro 
            340                 345                 350         


Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu Leu Cys Ala Leu 
        355                 360                 365             


Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp Asn Ala Glu Arg 
    370                 375                 380                 


Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu Phe Ser Gln Ala 
385                 390                 395                 400 


Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln Arg Tyr Leu Ser 
                405                 410                 415     


Ala Pro Glu Arg Asp Gln Ala Ala Ser Ala Ala Lys Leu Thr Ser Thr 
            420                 425                 430         


Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Cys Lys Arg Gln 
        435                 440                 445             


Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro Pro Pro Pro Pro 
    450                 455                 460                 


Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val Arg Asp Gly Lys 
465                 470                 475                 480 


Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala Tyr Gly Val Gly 
                485                 490                 495     


Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr Pro Gly Tyr Gly 
            500                 505                 510         


Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala Ala Tyr Pro Ala 
        515                 520                 525             


Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala Asn Asn Asn Phe 
    530                 535                 540                 


Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln Ser Pro Gly Ile 
545                 550                 555                 560 


Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly Ile Arg Ala Trp 
                565                 570                 575     


Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg 
            580                 585                 590         


Arg Arg Arg Arg 
        595     


<210>  139
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Leu Ala Val 
                245                 250                 255     


Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Ala Leu Ser Ser Pro 
            260                 265                 270         


Pro Ala Ala Ala Leu His Ser Met Ala Glu Met Lys Thr Pro Leu Tyr 
        275                 280                 285             


Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro Ser Ser Ser Ser 
    290                 295                 300                 


Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu Gly Thr His Asn 
305                 310                 315                 320 


Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu Ser Ser Leu Gly 
                325                 330                 335     


Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His Gly Ile Asn Asp 
            340                 345                 350         


Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly Ala Ala Leu Pro 
        355                 360                 365             


Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
    370                 375                 380                 


Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu Pro Arg Phe Ser 
                405                 410                 415     


Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr Phe Ser Pro Ser 
            420                 425                 430         


Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys Pro Leu Ala Glu 
        435                 440                 445             


Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val Met Gln Ser Pro 
    450                 455                 460                 


Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His Gln Gly Ser Ile 
465                 470                 475                 480 


Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg Pro Thr Phe Ser 
                485                 490                 495     


Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu Gln Thr Lys Tyr 
            500                 505                 510         


Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser Leu Gly Met Thr 
        515                 520                 525             


Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg Thr Lys Trp Arg 
    530                 535                 540                 


Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys Lys Gln Asp Ser 
545                 550                 555                 560 


Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu Glu Glu Asp Asp 
                565                 570                 575     


Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp Glu Lys Ile Thr 
            580                 585                 590         


Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly Gly Gly Gly Leu 
        595                 600                 605             


Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser Glu Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
625                 630                 635                 


<210>  140
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Tyr Arg Ser 
                245                 250                 255     


Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile Asn Ala Glu Ile 
            260                 265                 270         


Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala Asp Lys Ala Arg 
        275                 280                 285             


Ala Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile Tyr Thr Arg Lys 
    290                 295                 300                 


Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly Pro Thr Gly Leu 
305                 310                 315                 320 


Leu Ser Ala Gln Glu Leu Glu Asp Ile Val Ala Ala Leu Pro Gly Phe 
                325                 330                 335     


Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr Leu Ser Glu Ser 
            340                 345                 350         


Val Ser Glu His Leu Gly His Ser Met Val Asp Leu Val Ala Gln Gly 
        355                 360                 365             


Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His Leu Thr Val Arg 
    370                 375                 380                 


Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp Arg Leu Phe Arg 
385                 390                 395                 400 


Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln Ser Ala Gly Asn 
                405                 410                 415     


Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His Pro Pro Gly Ala 
            420                 425                 430         


Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys Ala Pro Leu Glu 
        435                 440                 445             


Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly Pro Ala Ser Leu 
    450                 455                 460                 


Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp Leu Ala Leu Leu 
465                 470                 475                 480 


Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe Glu Arg Ser Glu 
                485                 490                 495     


Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro Glu Asp Leu Ala 
            500                 505                 510         


His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu Ser Gly Asp Ile 
        515                 520                 525             


Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr Gly Gly Trp Ala 
    530                 535                 540                 


Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu Gly Pro Ile Thr 
545                 550                 555                 560 


Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp Ser Leu Arg Gln 
                565                 570                 575     


Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val Leu Gly Thr Pro 
            580                 585                 590         


Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser Gln Glu Glu Cys 
        595                 600                 605             


Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly Ala Pro Arg Ser 
    610                 615                 620                 


Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val Ser Ala Ser Glu 
625                 630                 635                 640 


Glu Leu Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser Tyr Leu Thr Phe 
                645                 650                 655     


Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu Ser Lys Asp Leu 
            660                 665                 670         


Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly Gly Cys Ala Phe 
        675                 680                 685             


Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu Pro Thr Pro Ser 
    690                 695                 700                 


Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala Thr Phe Ser Asp 
705                 710                 715                 720 


Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro Leu Thr Ser Pro 
                725                 730                 735     


Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser Tyr Glu Asp Gln 
            740                 745                 750         


Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu Leu Pro Ser Thr 
        755                 760                 765             


Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His Glu Gln Leu Thr 
    770                 775                 780                 


Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser Pro Ser Gln Thr 
785                 790                 795                 800 


Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr Tyr Phe Ala Gln 
                805                 810                 815     


Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro Ser Pro Ser Ser 
            820                 825                 830         


Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala Gln Leu Arg Gly 
        835                 840                 845             


Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly Leu Leu Thr Pro 
    850                 855                 860                 


Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr Ser Glu Lys Glu 
865                 870                 875                 880 


Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser Gln Leu Ala Gln 
                885                 890                 895     


Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr Gly Gly Leu Glu 
            900                 905                 910         


Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu Ser Leu Ser Gly 
        915                 920                 925             


Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro Trp Lys Cys Gln 
    930                 935                 940                 


Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe Leu Glu Glu Thr 
945                 950                 955                 960 


Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro Asp Pro Ser Glu 
                965                 970                 975     


Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro Gly Gly Ala Pro 
            980                 985                 990         


Ser Pro Cys Asn Asn Leu Ser Pro  Glu Asp His Ser Phe  Leu Glu Asp 
        995                 1000                 1005             


Leu Ala  Thr Tyr Glu Thr Ala  Phe Glu Thr Gly Val  Ser Ala Phe 
    1010                 1015                 1020             


Pro Tyr  Asp Gly Phe Thr Asp  Glu Leu His Gln Leu  Gln Ser Gln 
    1025                 1030                 1035             


Val Gln  Asp Ser Phe His Glu  Asp Gly Ser Gly Gly  Glu Pro Thr 
    1040                 1045                 1050             


Phe Glu  Ser Gly Gly Gly Gly  Ser Pro Gly Arg Arg  Arg Arg Arg 
    1055                 1060                 1065             


Arg Arg  Arg Arg Arg Arg 
    1070                 


<210>  141
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Phe Tyr Ser 
                245                 250                 255     


Gly Leu Leu Thr Glu Gly Gly Arg Lys Glu Thr Asp Met Arg Glu Ala 
            260                 265                 270         


Ala Ser Leu Arg Gln Gln Arg Arg Met Lys Gln Ala Val Gln Phe Ile 
        275                 280                 285             


His Lys Asp Ser Ala Asp Leu Leu Pro Leu Asp Gly Leu Lys Lys Leu 
    290                 295                 300                 


Gly Ser Ser Lys Asp Met Gln Pro His Asn Ile Leu Gln Arg Arg Leu 
305                 310                 315                 320 


Met Glu Thr Asn Leu Ser Lys Leu Arg Ser Gly Pro Arg Val Pro Trp 
                325                 330                 335     


Ala Ser Lys Thr Asn Lys Leu Asn Gln Ala Lys Ser Glu Gly Leu Lys 
            340                 345                 350         


Lys Ser Glu Glu Asp Asp Met Ile Leu Val Ser Cys Gln Cys Ala Gly 
        355                 360                 365             


Lys Asp Val Lys Ala Leu Val Asp Thr Gly Cys Leu Tyr Asn Leu Ile 
    370                 375                 380                 


Ser Leu Ala Cys Val Asp Arg Leu Gly Leu Lys Glu His Val Lys Ser 
385                 390                 395                 400 


His Lys His Glu Gly Glu Lys Leu Ser Leu Pro Arg His Leu Lys Val 
                405                 410                 415     


Val Gly Gln Ile Glu His Ala Val Ile Thr Ala Gly Ser Leu Arg Leu 
            420                 425                 430         


Asp Cys Pro Ala Ala Val Val Asp Asp Asn Glu Lys Asn Ala Ser Ala 
        435                 440                 445             


Gly Leu Gln Thr Leu Arg Ser Leu Lys Cys Ile Ile Asn Leu Asp Lys 
    450                 455                 460                 


His Arg Leu Ile Met Gly Lys Thr Asp Lys Glu Glu Ile Pro Phe Val 
465                 470                 475                 480 


Glu Thr Val Ser Leu Asn Glu Asp Asn Thr Ser Glu Ala Glu Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            500                 505                 510         


Arg 
    


<210>  142
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Gly His 
                245                 250                 255     


Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly Gly Gly Gly Asp 
            260                 265                 270         


Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro Arg Thr Trp Leu 
        275                 280                 285             


Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly Pro Gly Val Gly 
    290                 295                 300                 


Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro Pro Pro Tyr Glu 
305                 310                 315                 320 


Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val Gly Val Gly Leu 
                325                 330                 335     


Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu Gly Glu Ala Gly 
            340                 345                 350         


Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro Glu Pro Cys Thr 
        355                 360                 365             


Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys Leu Glu Gln Asn 
    370                 375                 380                 


Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys Glu Leu Glu Gln 
385                 390                 395                 400 


Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu Gly Tyr Thr Gln 
                405                 410                 415     


Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly Lys Val Phe Ser 
            420                 425                 430         


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
        435                 440                 445             


Met Cys Lys Ala Arg Pro Ala Ala Gln Lys Trp Val Glu Glu Ala Asp 
    450                 455                 460                 


Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu Thr Leu Val Gln 
465                 470                 475                 480 


Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg Val Arg Gly Asn 
                485                 490                 495     


Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr Leu Gln Gln Ile 
            500                 505                 510         


Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp Val Val Arg Val 
        515                 520                 525             


Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser Ser Ser Asp Tyr 
    530                 535                 540                 


Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro Phe Ser Gly Gly 
545                 550                 555                 560 


Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe Gly Thr Pro Gly 
                565                 570                 575     


Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser Val Pro Phe Pro 
            580                 585                 590         


Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr Leu Gly Ser Pro 
        595                 600                 605             


Met His Ser Asn Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg 
    610                 615                 620                 


Arg Arg Arg Arg Arg Arg Arg Arg 
625                 630         


<210>  143
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Asp Ser Asp 
                245                 250                 255     


Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu Pro Asp Asp Leu 
            260                 265                 270         


Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser Ala Phe Thr Gly 
        275                 280                 285             


Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro Pro Glu Leu Ser 
    290                 295                 300                 


Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala His Pro Gly Asp 
305                 310                 315                 320 


Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser Ser Thr Ser Ser 
                325                 330                 335     


Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys Asp Lys Lys Gln 
            340                 345                 350         


Met Thr Glu Pro Glu Ala Gln Gln Ala Arg Leu Lys Ile Asn Ser Arg 
        355                 360                 365             


Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met Asp Gly Leu Arg 
    370                 375                 380                 


Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg Lys Leu Ser Lys 
385                 390                 395                 400 


Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu Met Leu Thr Asn 
                405                 410                 415     


Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile Tyr Gly Gly His 
            420                 425                 430         


His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu Ala His Ser Ala 
        435                 440                 445             


Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala Ala His Ala Ala 
    450                 455                 460                 


His His Pro Ala Val His His Pro Ile Leu Pro Pro Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser Ala Ser Leu Pro 
                485                 490                 495     


Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro Pro His Gly Leu 
            500                 505                 510         


Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu Gly Gly Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp Gly Gly Met Pro 
    530                 535                 540                 


Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His His His Val Ser 
545                 550                 555                 560 


Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser Asp Ala Lys Glu 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg 
            580                 585                 590         


Arg Arg Arg 
        595 


<210>  144
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Gln Asn Ser 
                245                 250                 255     


His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            260                 265                 270         


Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu Ala His Ser Gly 
        275                 280                 285             


Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val Ser Asn Gly Cys 
    290                 295                 300                 


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Arg Pro 
305                 310                 315                 320 


Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr Pro Glu Val Val 
                325                 330                 335     


Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser Ile Phe Ala Trp 
            340                 345                 350         


Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys Thr Asn Asp Asn 
        355                 360                 365             


Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg Asn Leu Ala Ser 
    370                 375                 380                 


Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp Lys Leu Arg Met 
385                 390                 395                 400 


Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro Gly Trp Tyr Pro 
                405                 410                 415     


Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly Cys Gln Gln Gln 
            420                 425                 430         


Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser Asn Gly Glu Asp 
        435                 440                 445             


Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg Lys Leu Gln Arg 
    450                 455                 460                 


Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala Leu Glu Lys Glu 
465                 470                 475                 480 


Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg Glu Arg Ala Ala 
                485                 490                 495     


Ala Lys Ala Asp Leu Pro Glu Ala Arg Ile Gln Val Trp Phe Ser Asn 
            500                 505                 510         


Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg Asn Gln Arg Arg 
        515                 520                 525             


Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser Ser Ser Phe Ser 
    530                 535                 540                 


Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr Pro Val Ser Ser 
545                 550                 555                 560 


Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr Ala Leu Thr Asn 
                565                 570                 575     


Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr Met Ala Asn Asn 
            580                 585                 590         


Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser Ser Tyr Ser Cys 
        595                 600                 605             


Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser Tyr Asp Thr Tyr 
    610                 615                 620                 


Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln Pro Met Gly Thr 
625                 630                 635                 640 


Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly Val Ser Val Pro 
                645                 650                 655     


Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln Tyr Trp Pro Arg 
            660                 665                 670         


Leu Gln Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg 
        675                 680                 685             


Arg Arg Arg Arg Arg Arg 
    690                 


<210>  145
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Ala Leu 
                245                 250                 255     


Pro Gly Thr Val Pro Arg Met Met Arg Pro Ala Pro Gly Gln Asn Tyr 
            260                 265                 270         


Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro Leu Gly Gln Gly 
        275                 280                 285             


Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly Arg Pro Leu Pro 
    290                 295                 300                 


Asn His Ile Arg His Lys Ile Val Glu Met Ala His His Gly Ile Arg 
305                 310                 315                 320 


Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys Val Ser 
                325                 330                 335     


Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile Arg Pro Gly Ala 
            340                 345                 350         


Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro Asp Val Glu Lys 
        355                 360                 365             


Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met Phe Ser Trp Glu 
    370                 375                 380                 


Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp Arg Ser Thr Val 
385                 390                 395                 400 


Pro Ser Gly Ala Val Ser Ser Ala Ser Arg Val Leu Arg Ile Lys Phe 
                405                 410                 415     


Gly Lys Lys Glu Glu Glu Asp Glu Ala Asp Lys Lys Glu Asp Asp Gly 
            420                 425                 430         


Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu Gly Asp Lys Gly 
        435                 440                 445             


Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu Pro Asp Leu Pro 
    450                 455                 460                 


Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe Thr Ala Glu Gln 
465                 470                 475                 480 


Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His Tyr Pro Asp Ile 
                485                 490                 495     


Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu Thr Glu Ala Arg 
            500                 505                 510         


Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp Arg Lys Gln Ala 
        515                 520                 525             


Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu Pro Gly Gly Phe 
    530                 535                 540                 


Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln Leu Pro Asp Ser 
545                 550                 555                 560 


Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly Ser Thr Val His 
                565                 570                 575     


Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln Gly Gly Leu Ala 
            580                 585                 590         


Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr Gly Ala Arg His 
        595                 600                 605             


Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro Ala Ala Pro Ser 
    610                 615                 620                 


Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Pro Gln Val Met Ser 
625                 630                 635                 640 


Ile Leu Gly Asn Pro Ser Ala Val Pro Pro Gln Pro Gln Ala Asp Phe 
                645                 650                 655     


Ser Ile Ser Pro Leu His Gly Gly Leu Asp Ser Ala Thr Ser Ile Ser 
            660                 665                 670         


Ala Ser Cys Ser Gln Arg Ala Asp Ser Ile Lys Pro Gly Asp Ser Leu 
        675                 680                 685             


Pro Thr Ser Gln Ala Tyr Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr 
    690                 695                 700                 


Ser Val Asp Pro Val Ala Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser 
705                 710                 715                 720 


Glu Cys Leu Val Pro Trp Ala Ser Pro Val Pro Ile Pro Ser Pro Thr 
                725                 730                 735     


Pro Arg Ala Ser Cys Leu Phe Met Glu Ser Tyr Lys Val Val Ser Gly 
            740                 745                 750         


Trp Gly Met Ser Ile Ser Gln Met Glu Lys Leu Lys Ser Ser Gln Met 
        755                 760                 765             


Glu Gln Phe Thr Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg 
    770                 775                 780                 


Arg Arg Arg Arg Arg Arg Arg Arg 
785                 790         


<210>  146
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Asn Gly Glu 
                245                 250                 255     


Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp Pro Cys Ala Phe 
            260                 265                 270         


Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro Pro Ala Cys Leu 
        275                 280                 285             


Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His Pro Phe Pro Gly 
    290                 295                 300                 


Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp Ile Ser Pro Tyr 
305                 310                 315                 320 


Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala His Ala His His 
                325                 330                 335     


His Ala Pro Ala Gln Leu Ala Leu Pro His Pro Pro Ala Gly Pro Phe 
            340                 345                 350         


Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro Asn Arg Val Gln 
        355                 360                 365             


Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His Ala Trp Lys Gly 
    370                 375                 380                 


Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu Glu Asn Lys Arg 
385                 390                 395                 400 


Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu Leu Glu Lys Glu 
                405                 410                 415     


Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg Val Glu Leu Ala 
            420                 425                 430         


Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile Trp Phe Gln Asn 
        435                 440                 445             


Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys Arg Gly Gly Gly 
    450                 455                 460                 


Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu Gln Asp Cys Ala 
465                 470                 475                 480 


Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro Pro Pro Pro Pro 
                485                 490                 495     


Gly Gly Ala Val Pro Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg 
            500                 505                 510         


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        515                 520     


<210>  147
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Asp Thr 
                245                 250                 255     


Gly Ile Gln Arg Gly Ile Trp Asp Gly Asp Ala Lys Ala Val Gln Gln 
            260                 265                 270         


Cys Leu Thr Asp Ile Phe Thr Ser Val Tyr Thr Thr Cys Asp Ile Pro 
        275                 280                 285             


Glu Asn Ala Ile Phe Gly Pro Cys Val Leu Ser His Thr Ser Leu Tyr 
    290                 295                 300                 


Asp Ser Ile Ala Phe Ile Ala Leu Lys Ser Thr Asp Lys Arg Thr Val 
305                 310                 315                 320 


Pro Tyr Ile Phe Arg Val Asp Thr Ser Ala Ala Asn Gly Ser Ser Glu 
                325                 330                 335     


Gly Leu Met Trp Leu Arg Leu Val Gln Ser Ala Arg Asp Lys Glu Glu 
            340                 345                 350         


Gln Asn Leu Glu Ala Tyr Ile Lys Asn Gly Gln Leu Phe Tyr Arg Ser 
        355                 360                 365             


Ala Arg Arg Ala Ala Lys Asp Glu Glu Leu Leu Val Trp Tyr Gly Lys 
    370                 375                 380                 


Glu Leu Thr Glu Leu Leu Leu Leu Cys Pro Ser Arg Ser His Asn Lys 
385                 390                 395                 400 


Met Asn Gly Ser Ser Pro Tyr Thr Cys Leu Glu Cys Ser Gln Arg Phe 
                405                 410                 415     


Gln Phe Glu Phe Pro Tyr Val Ala His Leu Arg Phe Arg Cys Pro Lys 
            420                 425                 430         


Arg Leu His Ser Ala Asp Ile Ser Pro Gln Asp Glu Gln Gly Gly Gly 
        435                 440                 445             


Val Gly Thr Lys Asp His Gly Gly Gly Gly Gly Gly Gly Lys Asp Gln 
    450                 455                 460                 


Gln Gln Gln Gln Gln Glu Ala Pro Leu Gly Pro Gly Pro Lys Phe Cys 
465                 470                 475                 480 


Lys Ala Gly Pro Leu His His Tyr Pro Ser Pro Ser Pro Glu Ser Ser 
                485                 490                 495     


Asn Pro Ser Ala Ala Ala Gly Gly Ser Ser Ala Lys Pro Ser Thr Asp 
            500                 505                 510         


Phe His Asn Leu Ala Arg Glu Leu Glu Asn Ser Arg Gly Gly Ser Ser 
        515                 520                 525             


Cys Ser Pro Ala Gln Ser Leu Ser Ser Gly Ser Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Gly His Gln Glu Ala Glu Leu Ser Pro Asp Gly Ile Ala Thr Gly 
545                 550                 555                 560 


Gly Gly Lys Gly Lys Arg Lys Phe Pro Glu Glu Ala Ala Glu Gly Gly 
                565                 570                 575     


Gly Gly Ala Gly Leu Val Gly Gly Arg Gly Arg Phe Val Glu Arg Pro 
            580                 585                 590         


Leu Pro Ala Ser Lys Glu Asp Leu Val Cys Thr Pro Gln Gln Tyr Arg 
        595                 600                 605             


Ala Ser Gly Ser Tyr Phe Gly Leu Glu Glu Asn Gly Arg Leu Phe Ala 
    610                 615                 620                 


Pro Pro Ser Pro Glu Thr Gly Glu Ala Lys Arg Ser Ala Phe Val Glu 
625                 630                 635                 640 


Val Lys Lys Ala Ala Arg Ala Ala Ser Leu Gln Glu Glu Gly Thr Ala 
                645                 650                 655     


Asp Gly Ala Gly Val Ala Ser Glu Asp Gln Asp Ala Gly Gly Gly Gly 
            660                 665                 670         


Gly Ser Ser Thr Pro Ala Ala Ala Ser Pro Val Gly Ala Glu Lys Leu 
        675                 680                 685             


Leu Ala Pro Arg Pro Gly Gly Pro Leu Pro Ser Arg Leu Glu Gly Gly 
    690                 695                 700                 


Ser Pro Ala Arg Gly Ser Ala Phe Thr Ser Val Pro Gln Leu Gly Ser 
705                 710                 715                 720 


Ala Gly Ser Thr Ser Gly Gly Gly Gly Thr Gly Ala Gly Ala Ala Gly 
                725                 730                 735     


Gly Ala Gly Gly Gly Gln Gly Ala Ala Ser Asp Glu Arg Lys Ser Ala 
            740                 745                 750         


Phe Ser Gln Pro Ala Arg Ser Phe Ser Gln Leu Ser Pro Leu Val Leu 
        755                 760                 765             


Gly Gln Lys Leu Gly Ala Leu Glu Pro Cys His Pro Ala Asp Gly Val 
    770                 775                 780                 


Gly Pro Thr Arg Leu Tyr Pro Ala Ala Ala Asp Pro Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gln Gly Ala Ala Asp Leu Asn Gly Gly Cys Gly Ser Leu Pro Ser 
                805                 810                 815     


Gly Gly Gly Gly Leu Pro Lys Gln Ser Pro Phe Leu Tyr Ala Thr Ala 
            820                 825                 830         


Phe Trp Pro Lys Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        835                 840                 845             


Ala Ala Gly Pro Leu Gln Leu Gln Leu Pro Ser Ala Leu Thr Leu Leu 
    850                 855                 860                 


Pro Pro Ser Phe Thr Ser Leu Cys Leu Pro Ala Gln Asn Trp Cys Ala 
865                 870                 875                 880 


Lys Cys Asn Ala Ser Phe Arg Met Thr Ser Asp Leu Val Tyr His Met 
                885                 890                 895     


Arg Ser His His Lys Lys Glu Tyr Ala Met Glu Pro Leu Val Lys Arg 
            900                 905                 910         


Arg Arg Glu Glu Lys Leu Lys Cys Pro Ile Cys Asn Glu Ser Phe Arg 
        915                 920                 925             


Glu Arg His His Leu Ser Arg His Met Thr Ser His Asn Glu Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
945                 950                 955                 960 


Arg 
    


<210>  148
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Arg Arg 
                245                 250                 255     


Ser Glu Ser Pro Cys Leu Arg Asp Ser Pro Asp Arg Arg Ser Gly Ser 
            260                 265                 270         


Pro Asp Val Lys Gly Pro Pro Pro Val Lys Val Ala Arg Leu Glu Gln 
        275                 280                 285             


Asn Gly Ser Pro Met Gly Ala Arg Gly Arg Pro Asn Gly Ala Val Ala 
    290                 295                 300                 


Lys Ala Val Gly Gly Leu Met Ile Pro Val Phe Cys Val Val Glu Gln 
305                 310                 315                 320 


Leu Asp Gly Ser Leu Glu Tyr Asp Asn Arg Glu Glu His Ala Glu Phe 
                325                 330                 335     


Val Leu Val Arg Lys Asp Val Leu Phe Ser Gln Leu Val Glu Thr Ala 
            340                 345                 350         


Leu Leu Ala Leu Gly Tyr Ser His Ser Ser Ala Ala Gln Ala Gln Gly 
        355                 360                 365             


Ile Ile Lys Leu Gly Arg Trp Asn Pro Leu Pro Leu Ser Tyr Val Thr 
    370                 375                 380                 


Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln Asp Val Tyr His 
385                 390                 395                 400 


Val Val Thr Leu Lys Ile Gln Leu Gln Ser Cys Ser Lys Leu Glu Asp 
                405                 410                 415     


Leu Pro Ala Glu Gln Trp Asn His Ala Thr Val Arg Asn Ala Leu Lys 
            420                 425                 430         


Glu Leu Leu Lys Glu Met Asn Gln Ser Thr Leu Ala Lys Glu Cys Pro 
        435                 440                 445             


Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser Thr Tyr Tyr Ala 
    450                 455                 460                 


Asn Val Ser Ala Thr Lys Cys Gln Glu Phe Gly Arg Trp Tyr Lys Lys 
465                 470                 475                 480 


Tyr Lys Lys Ile Lys Val Glu Arg Val Glu Arg Glu Asn Leu Ser Asp 
                485                 490                 495     


Tyr Cys Val Leu Gly Gln Arg Pro Met His Leu Pro Asn Met Asn Gln 
            500                 505                 510         


Leu Ala Ser Leu Gly Lys Thr Asn Glu Gln Ser Pro His Ser Gln Ile 
        515                 520                 525             


His His Ser Thr Pro Ile Arg Asn Gln Val Pro Ala Leu Gln Pro Ile 
    530                 535                 540                 


Met Ser Pro Gly Leu Leu Ser Pro Gln Leu Ser Pro Gln Leu Val Arg 
545                 550                 555                 560 


Gln Gln Ile Ala Met Ala His Leu Ile Asn Gln Gln Ile Ala Val Ser 
                565                 570                 575     


Arg Leu Leu Ala His Gln His Pro Gln Ala Ile Asn Gln Gln Phe Leu 
            580                 585                 590         


Asn His Pro Pro Ile Pro Arg Ala Val Lys Pro Glu Pro Thr Asn Ser 
        595                 600                 605             


Ser Val Glu Val Ser Pro Asp Ile Tyr Gln Gln Val Arg Asp Glu Leu 
    610                 615                 620                 


Lys Arg Ala Ser Val Ser Gln Ala Val Phe Ala Arg Val Ala Phe Asn 
625                 630                 635                 640 


Arg Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro 
                645                 650                 655     


Arg Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg Ala Met Gln Asn 
            660                 665                 670         


Phe Leu Asn Leu Pro Glu Val Glu Arg Asp Arg Ile Tyr Gln Asp Glu 
        675                 680                 685             


Arg Glu Arg Ser Met Asn Pro Asn Val Ser Met Val Ser Ser Ala Ser 
    690                 695                 700                 


Ser Ser Pro Ser Ser Ser Arg Thr Pro Gln Ala Lys Thr Ser Thr Pro 
705                 710                 715                 720 


Thr Thr Asp Leu Pro Ile Lys Val Asp Gly Ala Asn Ile Asn Ile Thr 
                725                 730                 735     


Ala Ala Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg Ala Lys Val 
            740                 745                 750         


Ser Gln Ala Leu Phe Ala Lys Val Ala Ala Asn Lys Ser Gln Gly Trp 
        755                 760                 765             


Leu Cys Glu Leu Leu Arg Trp Lys Glu Asn Pro Ser Pro Glu Asn Arg 
    770                 775                 780                 


Thr Leu Trp Glu Asn Leu Cys Thr Ile Arg Arg Phe Leu Asn Leu Pro 
785                 790                 795                 800 


Gln His Glu Arg Asp Val Ile Tyr Glu Glu Glu Ser Arg His His His 
                805                 810                 815     


Ser Glu Arg Met Gln His Val Val Gln Leu Pro Pro Glu Pro Val Gln 
            820                 825                 830         


Val Leu His Arg Gln Gln Ser Gln Pro Ala Lys Glu Ser Ser Pro Pro 
        835                 840                 845             


Arg Glu Glu Ala Pro Pro Pro Pro Pro Pro Thr Glu Asp Ser Cys Ala 
    850                 855                 860                 


Lys Lys Pro Arg Ser Arg Thr Lys Ala Ser Ala Glu Ala Leu Gly Ile 
865                 870                 875                 880 


Leu Gln Ser Phe Ile His Asp Val Gly Leu Tyr Pro Asp Gln Glu Ala 
                885                 890                 895     


Ile His Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys His Thr Ile Ile 
            900                 905                 910         


Lys Phe Phe Gln Asn Gln Arg Tyr His Val Lys His His Gly Lys Leu 
        915                 920                 925             


Lys Glu His Leu Gly Ser Ala Val Asp Val Ala Glu Tyr Lys Asp Glu 
    930                 935                 940                 


Glu Leu Leu Thr Glu Ser Glu Glu Asn Asp Ser Glu Glu Gly Ser Glu 
945                 950                 955                 960 


Glu Met Tyr Lys Val Glu Ala Glu Glu Glu Asn Ala Asp Lys Ser Lys 
                965                 970                 975     


Ala Ala Pro Ala Glu Ile Asp Gln Arg Glu Ser Gly Gly Gly Gly Ser 
            980                 985                 990         


Pro Gly Arg Arg Arg Arg Arg Arg  Arg Arg Arg Arg Arg  
        995                 1000                 1005 


<210>  149
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Glu Leu 
                245                 250                 255     


Thr Ala Phe Val Ser Lys Ser Phe Asp Gln Lys Val Lys Glu Lys Lys 
            260                 265                 270         


Glu Ala Ile Thr Tyr Arg Glu Val Leu Glu Ser Gly Pro Leu Arg Gly 
        275                 280                 285             


Ala Lys Glu Pro Thr Gly Cys Thr Glu Ala Gly Arg Asp Asp Arg Ser 
    290                 295                 300                 


Ser Pro Ala Val Arg Ala Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly Gly Gly Ala Gly 
                325                 330                 335     


Gly Gly Ala Gly Gly Gly Arg Ser Pro Val Arg Glu Leu Asp Met Gly 
            340                 345                 350         


Ala Ala Glu Arg Ser Arg Glu Pro Gly Ser Pro Arg Leu Thr Glu Gly 
        355                 360                 365             


Arg Arg Lys Pro Thr Lys Ala Glu Val Gln Ala Thr Leu Leu Leu Pro 
    370                 375                 380                 


Gly Glu Ala Phe Arg Phe Leu Val Ser Pro Glu Leu Lys Asp Arg Lys 
385                 390                 395                 400 


Glu Asp Ala Lys Gly Met Glu Asp Glu Gly Gln Thr Lys Ile Lys Gln 
                405                 410                 415     


Arg Arg Ser Arg Thr Asn Phe Thr Leu Glu Gln Leu Asn Glu Leu Glu 
            420                 425                 430         


Arg Leu Phe Asp Glu Thr His Tyr Pro Asp Ala Phe Met Arg Glu Glu 
        435                 440                 445             


Leu Ser Gln Arg Leu Gly Leu Ser Glu Ala Arg Val Gln Val Trp Phe 
    450                 455                 460                 


Gln Asn Arg Arg Ala Lys Cys Arg Lys Gln Glu Asn Gln Leu His Lys 
465                 470                 475                 480 


Gly Val Leu Ile Gly Ala Ala Ser Gln Phe Glu Ala Cys Arg Val Ala 
                485                 490                 495     


Pro Tyr Val Asn Val Gly Ala Leu Arg Met Pro Phe Gln Gln Asp Ser 
            500                 505                 510         


His Cys Asn Val Thr Pro Leu Ser Phe Gln Val Gln Ala Gln Leu Gln 
        515                 520                 525             


Leu Asp Ser Ala Val Ala His Ala His His His Leu His Pro His Leu 
    530                 535                 540                 


Ala Ala His Ala Pro Tyr Met Met Phe Pro Ala Pro Pro Phe Gly Leu 
545                 550                 555                 560 


Pro Leu Ala Thr Leu Ala Ala Asp Ser Ala Ser Ala Ala Ser Val Val 
                565                 570                 575     


Ala Ala Ala Ala Ala Ala Lys Thr Thr Ser Lys Asn Ser Ser Ala Ala 
            580                 585                 590         


Asp Ala Arg Leu Lys Ala Lys Lys His Ala Ala Ala Leu Gly Leu Glu 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg 
    610                 615                 620                 


Arg Arg Arg 
625         


<210>  150
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Tyr Asn Met 
                245                 250                 255     


Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln Thr Ser Gly Gly 
            260                 265                 270         


Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly Asn Gln Lys Asn 
        275                 280                 285             


Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser 
    290                 295                 300                 


Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn 
305                 310                 315                 320 


Ser Glu Ala Ser Lys Arg Ala Gly Ala Glu Trp Lys Leu Leu Ser Glu 
                325                 330                 335     


Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu 
            340                 345                 350         


His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr 
        355                 360                 365             


Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro Gly Gly Leu Leu 
    370                 375                 380                 


Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly Val Gly Ala Gly 
385                 390                 395                 400 


Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr Ala His Met Asn 
                405                 410                 415     


Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp Gln Leu Gly Tyr 
            420                 425                 430         


Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala Gln Met Gln Pro 
        435                 440                 445             


Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn Ser Met Thr Ser 
    450                 455                 460                 


Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser Met Ser Tyr Ser 
465                 470                 475                 480 


Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met Gly Ser Val Val 
                485                 490                 495     


Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr Ser Ser Ser His 
            500                 505                 510         


Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp Met Ile Ser Met 
        515                 520                 525             


Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala Pro Ser Arg Leu 
    530                 535                 540                 


His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro Gly Thr Ala Ile 
545                 550                 555                 560 


Asn Gly Thr Leu Pro Leu Ser His Met Glu Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            580                 585                 


<210>  151
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Asn Leu Leu 
                245                 250                 255     


Asp Pro Phe Met Lys Met Thr Asp Glu Gln Glu Lys Gly Leu Ser Gly 
            260                 265                 270         


Ala Pro Ser Pro Thr Met Ser Glu Asp Ser Ala Gly Ser Pro Cys Pro 
        275                 280                 285             


Ser Gly Ser Gly Ser Asp Thr Glu Asn Thr Arg Pro Gln Glu Asn Thr 
    290                 295                 300                 


Phe Pro Lys Gly Glu Pro Asp Leu Lys Lys Glu Ser Glu Glu Asp Lys 
305                 310                 315                 320 


Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu Lys Gly Tyr 
                325                 330                 335     


Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly Ser Ser Lys 
            340                 345                 350         


Asn Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ala 
        355                 360                 365             


Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His Leu His Asn 
    370                 375                 380                 


Ala Glu Leu Ser Lys Thr Leu Gly Lys Ala Trp Arg Leu Leu Asn Glu 
385                 390                 395                 400 


Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val Gln 
                405                 410                 415     


His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg Arg Arg Lys 
            420                 425                 430         


Ser Val Lys Asn Gly Gln Ala Glu Ala Glu Glu Ala Thr Glu Gln Thr 
        435                 440                 445             


His Ile Ser Pro Asn Ala Ile Phe Lys Ala Leu Gln Ala Asp Ser Pro 
    450                 455                 460                 


His Ser Ser Ser Gly Met Ser Glu Val His Ser Pro Gly Glu His Ser 
465                 470                 475                 480 


Gly Gln Ser Gln Gly Pro Pro Thr Pro Pro Thr Thr Pro Lys Thr Asp 
                485                 490                 495     


Val Gln Pro Gly Lys Ala Asp Leu Lys Arg Glu Gly Arg Pro Leu Pro 
            500                 505                 510         


Glu Gly Gly Arg Gln Pro Pro Ile Asp Phe Arg Asp Val Asp Ile Gly 
        515                 520                 525             


Glu Leu Ser Ser Asp Val Ile Ser Asn Ile Glu Thr Phe Asp Val Asn 
    530                 535                 540                 


Glu Phe Asp Gln Tyr Leu Pro Pro Asn Gly His Pro Gly Val Pro Ala 
545                 550                 555                 560 


Thr His Gly Gln Val Thr Tyr Thr Gly Ser Tyr Gly Ile Ser Ser Thr 
                565                 570                 575     


Ala Ala Thr Pro Ala Ser Ala Gly His Val Trp Met Ser Lys Gln Gln 
            580                 585                 590         


Ala Pro Pro Pro Pro Pro Gln Gln Pro Pro Gln Ala Pro Pro Ala Pro 
        595                 600                 605             


Gln Ala Pro Pro Gln Pro Gln Ala Ala Pro Pro Gln Gln Pro Ala Ala 
    610                 615                 620                 


Pro Pro Gln Gln Pro Gln Ala His Thr Leu Thr Thr Leu Ser Ser Glu 
625                 630                 635                 640 


Pro Gly Gln Ser Gln Arg Thr His Ile Lys Thr Glu Gln Leu Ser Pro 
                645                 650                 655     


Ser His Tyr Ser Glu Gln Gln Gln His Ser Pro Gln Gln Ile Ala Tyr 
            660                 665                 670         


Ser Pro Phe Asn Leu Pro His Tyr Ser Pro Ser Tyr Pro Pro Ile Thr 
        675                 680                 685             


Arg Ser Gln Tyr Asp Tyr Thr Asp His Gln Asn Ser Ser Ser Tyr Tyr 
    690                 695                 700                 


Ser His Ala Ala Gly Gln Gly Thr Gly Leu Tyr Ser Thr Phe Thr Tyr 
705                 710                 715                 720 


Met Asn Pro Ala Gln Arg Pro Met Tyr Thr Pro Ile Ala Asp Thr Ser 
                725                 730                 735     


Gly Val Pro Ser Ile Pro Gln Thr His Ser Pro Gln His Trp Glu Gln 
            740                 745                 750         


Pro Val Tyr Thr Gln Leu Thr Arg Pro Glu Ser Gly Gly Gly Gly Ser 
        755                 760                 765             


Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    770                 775                 780     


<210>  152
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Gln Leu Glu 
                245                 250                 255     


His Cys Leu Ser Pro Ser Ile Met Leu Ser Lys Lys Phe Leu Asn Val 
            260                 265                 270         


Ser Ser Ser Tyr Pro His Ser Gly Gly Ser Glu Leu Val Leu His Asp 
        275                 280                 285             


His Pro Ile Ile Ser Thr Thr Asp Asn Leu Glu Arg Ser Ser Pro Leu 
    290                 295                 300                 


Lys Lys Ile Thr Arg Gly Met Thr Asn Gln Ser Asp Thr Asp Asn Phe 
305                 310                 315                 320 


Pro Asp Ser Lys Asp Ser Pro Gly Asp Val Gln Arg Ser Lys Leu Ser 
                325                 330                 335     


Pro Val Leu Asp Gly Val Ser Glu Leu Arg His Ser Phe Asp Gly Ser 
            340                 345                 350         


Ala Ala Asp Arg Tyr Leu Leu Ser Gln Ser Ser Gln Pro Gln Ser Ala 
        355                 360                 365             


Ala Thr Ala Pro Ser Ala Met Phe Pro Tyr Pro Gly Gln His Gly Pro 
    370                 375                 380                 


Ala His Pro Ala Phe Ser Ile Gly Ser Pro Ser Arg Tyr Met Ala His 
385                 390                 395                 400 


His Pro Val Ile Thr Asn Gly Ala Tyr Asn Ser Leu Leu Ser Asn Ser 
                405                 410                 415     


Ser Pro Gln Gly Tyr Pro Thr Ala Gly Tyr Pro Tyr Pro Gln Gln Tyr 
            420                 425                 430         


Gly His Ser Tyr Gln Gly Ala Pro Phe Tyr Gln Phe Ser Ser Thr Gln 
        435                 440                 445             


Pro Gly Leu Val Pro Gly Lys Ala Gln Val Tyr Leu Cys Asn Arg Pro 
    450                 455                 460                 


Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile Ile Thr Lys 
465                 470                 475                 480 


Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile Ser Gly Leu 
                485                 490                 495     


Asp Pro Thr Ala His Tyr Asn Ile Phe Val Asp Val Ile Leu Ala Asp 
            500                 505                 510         


Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Pro Cys Gly Lys 
        515                 520                 525             


Ala Asp Thr Asn Val Gln Gly Asn Arg Val Tyr Met His Pro Asp Ser 
    530                 535                 540                 


Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Ile Ser Ala Gly Lys 
545                 550                 555                 560 


Ala Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Asn Gly Gln Met 
                565                 570                 575     


Val Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Val Val 
            580                 585                 590         


Glu Val Asn Glu Asp Gly Thr Glu Asp Thr Ser Gln Pro Gly Arg Val 
        595                 600                 605             


Gln Thr Phe Thr Phe Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr 
    610                 615                 620                 


Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn Pro Phe Ala 
625                 630                 635                 640 


Lys Gly Phe Arg Asp Asn Tyr Asp Thr Ile Tyr Thr Gly Cys Asp Met 
                645                 650                 655     


Asp Arg Leu Thr Pro Ser Pro Asn Asp Ser Pro Arg Ser Gln Ile Val 
            660                 665                 670         


Pro Gly Ala Arg Tyr Ala Met Ala Gly Ser Phe Leu Gln Asp Gln Phe 
        675                 680                 685             


Val Ser Asn Tyr Ala Lys Ala Arg Phe His Pro Gly Ala Gly Ala Gly 
    690                 695                 700                 


Pro Gly Pro Gly Thr Asp Arg Ser Val Pro His Thr Asn Gly Leu Leu 
705                 710                 715                 720 


Ser Pro Gln Gln Ala Glu Asp Pro Gly Ala Pro Ser Pro Gln Arg Trp 
                725                 730                 735     


Phe Val Thr Pro Ala Asn Asn Arg Leu Asp Phe Ala Ala Ser Ala Tyr 
            740                 745                 750         


Asp Thr Ala Thr Asp Phe Ala Gly Asn Ala Ala Thr Leu Leu Ser Tyr 
        755                 760                 765             


Ala Ala Ala Gly Val Lys Ala Leu Pro Leu Gln Ala Ala Gly Cys Thr 
    770                 775                 780                 


Gly Arg Pro Leu Gly Tyr Tyr Ala Asp Pro Ser Gly Trp Gly Ala Arg 
785                 790                 795                 800 


Ser Pro Pro Gln Tyr Cys Gly Thr Lys Ser Gly Ser Val Leu Pro Cys 
                805                 810                 815     


Trp Pro Asn Ser Ala Ala Ala Ala Ala Arg Met Ala Gly Ala Asn Pro 
            820                 825                 830         


Tyr Leu Gly Glu Glu Ala Glu Gly Leu Ala Ala Glu Arg Ser Pro Leu 
        835                 840                 845             


Pro Pro Gly Ala Ala Glu Asp Ala Lys Pro Lys Asp Leu Ser Asp Ser 
    850                 855                 860                 


Ser Trp Ile Glu Thr Pro Ser Ser Ile Lys Ser Ile Asp Ser Ser Asp 
865                 870                 875                 880 


Ser Gly Ile Tyr Glu Gln Ala Lys Arg Arg Arg Ile Ser Pro Ala Asp 
                885                 890                 895     


Thr Pro Val Ser Glu Ser Ser Ser Pro Leu Lys Ser Glu Val Leu Ala 
            900                 905                 910         


Gln Arg Asp Cys Glu Lys Asn Cys Ala Lys Asp Ile Ser Gly Tyr Tyr 
        915                 920                 925             


Gly Phe Tyr Ser His Ser Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg 
    930                 935                 940                 


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
945                 950                 


<210>  153
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Asp Ala 
                245                 250                 255     


Asp Glu Ala Leu Ala Gly Ala His Leu Trp Ser Leu Thr Gln Lys Thr 
            260                 265                 270         


Cys Leu Arg Phe Glu Pro Arg Ala Arg Ser Gly Pro Pro Ala Ser Pro 
        275                 280                 285             


Pro Gly Arg Pro Arg Ser Arg Leu His Pro Ala Gly Met Glu Gly Ile 
    290                 295                 300                 


Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys Phe His Glu Val 
305                 310                 315                 320 


Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met Phe Pro Ser Tyr 
                325                 330                 335     


Lys Val Lys Val Thr Gly Ile Asn Pro Lys Thr Lys Tyr Ile Leu Leu 
            340                 345                 350         


Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys Phe Ala Asp Asn 
        355                 360                 365             


Lys Trp Cys Val Thr Gly Lys Ala Glu Pro Ala Met Ala Gly Arg Leu 
    370                 375                 380                 


Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His Trp Met Arg Gln 
385                 390                 395                 400 


Ala Val Ser Ala Gln Lys Leu Lys Leu Thr Asn Asn His Leu Asp Pro 
                405                 410                 415     


Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr Gln Pro Arg Leu 
            420                 425                 430         


His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe Gly Ser Lys Asn Thr 
        435                 440                 445             


Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala Phe Ile Ala Val Thr 
    450                 455                 460                 


Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile Glu Asn Asn Pro 
465                 470                 475                 480 


Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met Glu Leu His Arg Met 
                485                 490                 495     


Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val Pro Arg Ser Thr Val 
            500                 505                 510         


Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe Ser Ser Glu Ser Arg 
        515                 520                 525             


Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln Tyr Gln Cys Glu Asn 
    530                 535                 540                 


Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro Pro Pro Asn Pro Tyr 
545                 550                 555                 560 


Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His Cys Thr Lys Arg Lys 
                565                 570                 575     


Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr Lys Lys Pro Tyr Met 
            580                 585                 590         


Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr Arg Ser Ser Tyr Pro 
        595                 600                 605             


Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr Glu Ser Ala Gln Arg 
    610                 615                 620                 


Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro Ser Glu Pro Val Pro 
625                 630                 635                 640 


Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro Ser Met Pro Ser Tyr 
                645                 650                 655     


Ser Ser Cys Thr Val Thr Thr Val Gln Pro Trp Thr Gly Tyr Pro Thr 
            660                 665                 670         


Ser Thr Ser Pro Leu Thr Ser Pro Arg Gly Pro Trp Ser Leu Gly Trp 
        675                 680                 685             


Leu Ala Trp Gln Pro Trp Leu Pro Thr Ala Gly Arg Gly Asn Val Pro 
    690                 695                 700                 


Ser Thr Arg Pro Pro Val Ala His Gln Pro Val Val Ser Ser Val Gly 
705                 710                 715                 720 


Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu Gln Pro Pro Glu Phe 
                725                 730                 735     


Leu Tyr Ser His Gly Val Gln Gly Leu Tyr Pro Leu Ile Ser Thr Thr 
            740                 745                 750         


Leu Cys Thr Glu Leu Ala Trp Cys Arg Val Glu Arg Gln Glu Ser Gly 
        755                 760                 765             


Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
    770                 775                 780                 


Arg 
785 


<210>  154
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Glu Lys 
                245                 250                 255     


Arg Arg Gly Ser Pro Cys Ser Met Leu Ser Leu Lys Ala His Ala Phe 
            260                 265                 270         


Ser Val Glu Ala Leu Ile Gly Ala Glu Lys Gln Gln Gln Leu Gln Lys 
        275                 280                 285             


Lys Arg Arg Lys Leu Gly Ala Glu Glu Ala Ala Gly Ala Val Asp Asp 
    290                 295                 300                 


Gly Gly Cys Ser Arg Gly Gly Gly Ala Gly Glu Lys Gly Ser Ser Glu 
305                 310                 315                 320 


Gly Asp Glu Gly Ala Ala Leu Pro Pro Pro Ala Gly Ala Thr Ser Gly 
                325                 330                 335     


Pro Ala Arg Ser Gly Ala Asp Leu Glu Arg Gly Ala Ala Gly Gly Cys 
            340                 345                 350         


Glu Asp Gly Phe Gln Gln Gly Ala Ser Pro Leu Ala Ser Pro Gly Gly 
        355                 360                 365             


Ser Pro Lys Gly Ser Pro Ala Arg Ser Leu Ala Arg Pro Gly Thr Pro 
    370                 375                 380                 


Leu Pro Ser Pro Gln Ala Pro Arg Val Asp Leu Gln Gly Ala Glu Leu 
385                 390                 395                 400 


Trp Lys Arg Phe His Glu Ile Gly Thr Glu Met Ile Ile Thr Lys Ala 
                405                 410                 415     


Gly Arg Arg Met Phe Pro Ala Met Arg Val Lys Ile Ser Gly Leu Asp 
            420                 425                 430         


Pro His Gln Gln Tyr Tyr Ile Ala Met Asp Ile Val Pro Val Asp Asn 
        435                 440                 445             


Lys Arg Tyr Arg Tyr Val Tyr His Ser Ser Lys Trp Met Val Ala Gly 
    450                 455                 460                 


Asn Ala Asp Ser Pro Val Pro Pro Arg Val Tyr Ile His Pro Asp Ser 
465                 470                 475                 480 


Pro Ala Ser Gly Glu Thr Trp Met Arg Gln Ala Ile Ser Ala Asp Lys 
                485                 490                 495     


Leu Lys Leu Thr Asn Asn Glu Leu Asp Asp Gln Gly His Ile Ile Leu 
            500                 505                 510         


His Ser Met His Lys Tyr Gln Pro Arg Val His Val Ile Arg Lys Asp 
        515                 520                 525             


Cys Gly Asp Asp Leu Ser Pro Ile Lys Pro Val Pro Ser Gly Glu Gly 
    530                 535                 540                 


Val Lys Ala Phe Ser Phe Pro Glu Thr Val Phe Thr Thr Val Thr Ala 
545                 550                 555                 560 


Tyr Gln Asn Gln Gln Ile Thr Arg Leu Lys Ile Asp Arg Asn Pro Phe 
                565                 570                 575     


Ala Lys Gly Phe Arg Asp Ser Gly Arg Asn Arg Met Gly Leu Glu Ala 
            580                 585                 590         


Leu Val Glu Ser Tyr Ala Phe Trp Arg Pro Ser Leu Arg Thr Leu Thr 
        595                 600                 605             


Phe Glu Asp Ile Pro Gly Ile Pro Lys Gln Gly Asn Ala Ser Ser Ser 
    610                 615                 620                 


Thr Leu Leu Gln Gly Thr Gly Asn Gly Val Pro Ala Thr His Pro His 
625                 630                 635                 640 


Leu Leu Ser Gly Ser Ser Cys Ser Ser Pro Ala Phe His Leu Gly Pro 
                645                 650                 655     


Asn Thr Ser Gln Leu Cys Ser Leu Ala Pro Ala Asp Tyr Ser Ala Cys 
            660                 665                 670         


Ala Arg Ser Gly Leu Thr Leu Asn Arg Tyr Ser Thr Ser Leu Ala Glu 
        675                 680                 685             


Thr Tyr Asn Arg Leu Thr Asn Gln Ala Gly Glu Thr Phe Ala Pro Pro 
    690                 695                 700                 


Arg Thr Pro Ser Tyr Val Gly Val Ser Ser Ser Thr Ser Val Asn Met 
705                 710                 715                 720 


Ser Met Gly Gly Thr Asp Gly Asp Thr Phe Ser Cys Pro Gln Thr Ser 
                725                 730                 735     


Leu Ser Met Gln Ile Ser Gly Met Ser Pro Gln Leu Gln Tyr Ile Met 
            740                 745                 750         


Pro Ser Pro Ser Ser Asn Ala Phe Ala Thr Asn Gln Thr His Gln Gly 
        755                 760                 765             


Ser Tyr Asn Thr Phe Arg Leu His Ser Pro Cys Ala Leu Tyr Gly Tyr 
    770                 775                 780                 


Asn Phe Ser Thr Ser Pro Lys Leu Ala Ala Ser Pro Glu Lys Ile Val 
785                 790                 795                 800 


Ser Ser Gln Gly Ser Phe Leu Gly Ser Ser Pro Ser Gly Thr Met Thr 
                805                 810                 815     


Asp Arg Gln Met Leu Pro Pro Val Glu Gly Val His Leu Leu Ser Ser 
            820                 825                 830         


Gly Gly Gln Gln Ser Phe Phe Asp Ser Arg Thr Leu Gly Ser Leu Thr 
        835                 840                 845             


Leu Ser Ser Ser Gln Val Ser Ala His Met Val Glu Ser Gly Gly Gly 
    850                 855                 860                 


Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
865                 870                 875                 


<210>  155
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Leu Leu Asp 
                245                 250                 255     


Ala Gly Pro Gln Tyr Pro Ala Ile Gly Val Thr Thr Phe Gly Ala Ser 
            260                 265                 270         


Arg His His Ser Ala Gly Asp Ala Ala Glu Arg Asp Ala Gly Leu Gly 
        275                 280                 285             


Ile Asn Pro Phe Ala Asp Gly Met Gly Ala Phe Lys Leu Asn Pro Ser 
    290                 295                 300                 


Ser His Glu Leu Ala Ser Ala Gly Gln Thr Ala Phe Thr Ser Gln Ala 
305                 310                 315                 320 


Pro Gly Tyr Ala Ala Ala Ala Ala Leu Gly His His His His Pro Gly 
                325                 330                 335     


His Val Gly Ser Tyr Ser Ser Ala Ala Phe Asn Ser Thr Arg Asp Phe 
            340                 345                 350         


Leu Phe Arg Asn Arg Gly Phe Gly Asp Ala Ala Ala Ala Ala Ser Ala 
        355                 360                 365             


Gln His Ser Leu Phe Ala Ala Ser Ala Gly Gly Phe Gly Gly Pro His 
    370                 375                 380                 


Gly His Thr Asp Ala Ala Gly His Leu Leu Phe Pro Gly Leu His Glu 
385                 390                 395                 400 


Gln Ala Ala Gly His Ala Ser Pro Asn Val Val Asn Gly Gln Met Arg 
                405                 410                 415     


Leu Gly Phe Ser Gly Asp Met Tyr Pro Arg Pro Glu Gln Tyr Gly Gln 
            420                 425                 430         


Val Thr Ser Pro Arg Ser Glu His Tyr Ala Ala Pro Gln Leu His Gly 
        435                 440                 445             


Tyr Gly Pro Met Asn Val Asn Met Ala Ala His His Gly Ala Gly Ala 
    450                 455                 460                 


Phe Phe Arg Tyr Met Arg Gln Pro Ile Lys Gln Glu Leu Ile Cys Lys 
465                 470                 475                 480 


Trp Ile Glu Pro Glu Gln Leu Ala Asn Pro Lys Lys Ser Cys Asn Lys 
                485                 490                 495     


Thr Phe Ser Thr Met His Glu Leu Val Thr His Val Thr Val Glu His 
            500                 505                 510         


Val Gly Gly Pro Glu Gln Ser Asn His Ile Cys Phe Trp Glu Glu Cys 
        515                 520                 525             


Pro Arg Glu Gly Lys Pro Phe Lys Ala Lys Tyr Lys Leu Val Asn His 
    530                 535                 540                 


Ile Arg Val His Thr Gly Glu Lys Pro Phe Pro Cys Pro Phe Pro Gly 
545                 550                 555                 560 


Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys Ile His Lys Arg 
                565                 570                 575     


Thr His Thr Gly Glu Lys Pro Phe Lys Cys Glu Phe Glu Gly Cys Asp 
            580                 585                 590         


Arg Arg Phe Ala Asn Ser Ser Asp Arg Lys Lys His Met His Val His 
        595                 600                 605             


Thr Ser Asp Lys Pro Tyr Leu Cys Lys Met Cys Asp Lys Ser Tyr Thr 
    610                 615                 620                 


His Pro Ser Ser Leu Arg Lys His Met Lys Val His Glu Ser Ser Ser 
625                 630                 635                 640 


Gln Gly Ser Gln Pro Ser Pro Ala Ala Ser Ser Gly Tyr Glu Ser Ser 
                645                 650                 655     


Thr Pro Pro Thr Ile Val Ser Pro Ser Thr Asp Asn Pro Thr Thr Ser 
            660                 665                 670         


Ser Leu Ser Pro Ser Ser Ser Ala Val His His Thr Ala Gly His Ser 
        675                 680                 685             


Ala Leu Ser Ser Asn Phe Asn Glu Trp Tyr Val Glu Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
705                 710                 715                 


<210>  156
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Gly His 
                245                 250                 255     


Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly Gly Gly Gly Asp 
            260                 265                 270         


Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro Arg Thr Trp Leu 
        275                 280                 285             


Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly Pro Gly Val Gly 
    290                 295                 300                 


Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro Pro Pro Tyr Glu 
305                 310                 315                 320 


Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val Gly Val Gly Leu 
                325                 330                 335     


Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu Gly Glu Ala Gly 
            340                 345                 350         


Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro Glu Pro Cys Thr 
        355                 360                 365             


Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys Leu Glu Gln Asn 
    370                 375                 380                 


Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys Glu Leu Glu Gln 
385                 390                 395                 400 


Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu Gly Tyr Thr Gln 
                405                 410                 415     


Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly Lys Val Phe Ser 
            420                 425                 430         


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
        435                 440                 445             


Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val Glu Glu Ala Asp 
    450                 455                 460                 


Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu Thr Leu Val Gln 
465                 470                 475                 480 


Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg Val Arg Gly Asn 
                485                 490                 495     


Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr Leu Gln Gln Ile 
            500                 505                 510         


Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp Val Val Arg Val 
        515                 520                 525             


Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser Ser Ser Asp Tyr 
    530                 535                 540                 


Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro Phe Ser Gly Gly 
545                 550                 555                 560 


Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe Gly Thr Pro Gly 
                565                 570                 575     


Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser Val Pro Phe Pro 
            580                 585                 590         


Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr Leu Gly Ser Pro 
        595                 600                 605             


Met His Ser Asn Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg 
    610                 615                 620                 


Arg Arg Arg Arg Arg Arg Arg Arg 
625                 630         


<210>  157
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His Met Glu Leu Leu 
                245                 250                 255     


Ser Pro Pro Leu Arg Asp Val Asp Leu Thr Ala Pro Asp Gly Ser Leu 
            260                 265                 270         


Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp Pro Cys Phe Asp 
        275                 280                 285             


Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro Arg Leu Met His 
    290                 295                 300                 


Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His Phe Pro Ala Ala 
305                 310                 315                 320 


Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His Val Arg Ala Pro 
                325                 330                 335     


Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp Ala Cys Lys Ala 
            340                 345                 350         


Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys Ala Ala Thr Met 
        355                 360                 365             


Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala Phe Glu Thr Leu 
    370                 375                 380                 


Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu Pro Lys Val Glu 
385                 390                 395                 400 


Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu Gln Ala Leu Leu 
                405                 410                 415     


Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala Ala Phe Tyr Ala 
            420                 425                 430         


Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His Tyr Ser Gly Asp 
        435                 440                 445             


Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp Gly Met Met Asp 
    450                 455                 460                 


Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn Cys Tyr Glu Gly 
465                 470                 475                 480 


Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro Gly Lys Ser Ala 
                485                 490                 495     


Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val Glu Arg Ile Ser 
            500                 505                 510         


Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala Asp Val Pro Ser 
        515                 520                 525             


Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro Ser Glu Gly Glu 
    530                 535                 540                 


Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala Pro Gln Cys Pro 
545                 550                 555                 560 


Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu Glu Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            580                 585                 590         


<210>  158
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158

Met Ala Ser Lys Gly Glu Arg Leu Phe Arg Gly Lys Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Lys Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Lys Gly Lys Gly Asp Ala Thr Arg Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Lys His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Lys Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Lys Asp Gly Lys Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Arg Thr Leu Val Asn Arg Ile Lys Leu Lys Gly 
        115                 120                 125             


Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu Gly His Lys Leu Arg Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Arg Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Lys Phe Lys Ile Arg His Asn Val Lys Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Arg Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Arg Asn His Tyr Leu Ser Thr Arg Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Lys Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Lys His Gly Arg Asp Glu Arg Tyr Lys Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Lys Lys Lys Arg 
                245                 250                 255     


Lys Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser His 
            260                 265                 270         


Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Val Asp Leu Thr Ala Pro 
        275                 280                 285             


Asp Gly Ser Leu Cys Ser Phe Ala Thr Thr Asp Asp Phe Tyr Asp Asp 
    290                 295                 300                 


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
305                 310                 315                 320 


Arg Leu Met His Val Gly Ala Leu Leu Lys Pro Glu Glu His Ser His 
                325                 330                 335     


Phe Pro Ala Ala Val His Pro Ala Pro Gly Ala Arg Glu Asp Glu His 
            340                 345                 350         


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
        355                 360                 365             


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
    370                 375                 380                 


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
385                 390                 395                 400 


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
                405                 410                 415     


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
            420                 425                 430         


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
        435                 440                 445             


Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Gly Glu His 
    450                 455                 460                 


Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp 
465                 470                 475                 480 


Gly Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Ala Arg Arg Arg Asn 
                485                 490                 495     


Cys Tyr Glu Gly Ala Tyr Tyr Asn Glu Ala Pro Ser Glu Pro Arg Pro 
            500                 505                 510         


Gly Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val 
        515                 520                 525             


Glu Arg Ile Ser Thr Glu Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala 
    530                 535                 540                 


Asp Val Pro Ser Glu Ser Pro Pro Arg Arg Gln Glu Ala Ala Ala Pro 
545                 550                 555                 560 


Ser Glu Gly Glu Ser Ser Gly Asp Pro Thr Gln Ser Pro Asp Ala Ala 
                565                 570                 575     


Pro Gln Cys Pro Ala Gly Ala Asn Pro Asn Pro Ile Tyr Gln Val Leu 
            580                 585                 590         


Glu Ser Gly Gly Gly Gly Ser Pro Gly Arg Arg Arg Arg Arg Arg Arg 
        595                 600                 605             


Arg Arg Arg Arg 
    610         


