                         SEQUENCE LISTING

<110>  BIOLINERX LTD.
       YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW 
       UNIVERSITY OF JERUSALEM LTD.
       B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD.
       Porgador, Angel
       Mandelboim, Ofer
       Nedvetzki, Shlomo
 
<120>  ANTIBODY FOR TREATING DIABETES AND AUTOIMMUNE DISEASES

<130>  59908

<140>  US 61/859,855
<141>  2013-07-30

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 hybridoma heavy chain coding sequence

<400>  1
atggctgtcc tggcgctact cctctgcctg gtgactttcc caagctgtat cctttcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcaca      120

tgcactgtct ctgggttctc attaaccagc tatggtgtag actgggttcg ccagtctcca      180

ggaaagggtc tggagtggct gggaataata tggggtgttg gaatcacaaa ttataattca      240

gctctcaaat ccagactgag catcagcaag gacaactcca agagccaagt tttcttaaaa      300

atgaacagtc tgcaaactga tgacacagcc atgtactact gtgccacata tgattacgac      360

ggggggtttg cttactgggg ccaagggact ctggtcactg tctctgca                   408


<210>  2
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 hybridoma heavy chain polypeptide sequence

<400>  2

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Ile Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val Asp Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Ile Ile Trp Gly Val Gly Ile Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Thr Tyr Asp Tyr Asp Gly Gly Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala 
    130                 135     


<210>  3
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR1 coding sequence

<400>  3
gggttctcat taaccagcta tggtgtagac                                        30


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR1 sequence

<400>  4

Gly Phe Ser Leu Thr Ser Tyr Gly Val Asp 
1               5                   10  


<210>  5
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR2 coding sequence

<400>  5
ataatatggg gtgttggaat cacaaattat aattcagctc tcaaatcc                    48


<210>  6
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR2 sequence

<400>  6

Ile Ile Trp Gly Val Gly Ile Thr Asn Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR3 coding sequence

<400>  7
tatgattacg acggggggtt tgcttac                                           27


<210>  8
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 heavy chain CDR3 sequence

<400>  8

Tyr Asp Tyr Asp Gly Gly Phe Ala Tyr 
1               5                   


<210>  9
<211>  390
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 hybridoma light chain coding sequence

<400>  9
atggattttc tggtgcagat tttcagcttc ttgctaatca gtgcctcagt tgcaatgtcc       60

agaggagaaa atgtgctcac ccagtctcca gcaatcatgt ctgcatctcc aggggaaaag      120

gtcaccatga cctgcagggc cagttcaagt gtaagttcca gttacttgca gtggtaccag      180

cagaagtcag gtgcctcccc caaactctgg atttatagca catccaactt ggcttctgga      240

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcagt      300

gtggaggctg aagatgctgc cacttattac tgccagcagt acagtggtta cccactcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa                                       390


<210>  10
<211>  130
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 hybridoma light chain polypeptide sequence

<400>  10

Met Asp Phe Leu Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ala Met Ser Arg Gly Glu Asn Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Ser Ser Tyr Leu Gln Trp Tyr Gln Gln Lys Ser Gly 
    50                  55                  60                  


Ala Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Tyr Ser Gly Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  11
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR1 coding sequence

<400>  11
gggccagttc aagtgtaagt tccagttact tgcag                                  35


<210>  12
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR1 sequence

<400>  12

Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Gln 
1               5                   10          


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR2 coding sequence

<400>  13
agcacatcca acttggcttc t                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR2 sequence

<400>  14

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR3 coding sequence

<400>  15
cagcagtaca gtggttaccc actcacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.80.2 light chain CDR3 sequence

<400>  16

Gln Gln Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  426
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 hybridoma heavy chain coding sequence

<400>  17
atggacttca ggctcagctt acttattttt gtccttattt taaaaggtgt ccagtgtgag       60

gtgaagctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtgac tacggaatgg cgtgggttcg acaggctcca      180

aggaaggggc ctgagtgggt agcatttatt agttatttga catatagtat ctactatgca      240

gacactgtga cgggccgatt caccatctct agagaaaatg ccaagaacac cctgttccta      300

gaaatgagca gtctgaggtc tgaggacacg gccatatatt actgtgcaag acaggggggc      360

tatgatggtt acccttactg gtacttcgat gtctggggca cagggaccac ggtcaccgtc      420

tcctca                                                                 426


<210>  18
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 hybridoma heavy chain polypeptide sequence

<400>  18

Met Asp Phe Arg Leu Ser Leu Leu Ile Phe Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Arg Lys Gly Pro 
    50                  55                  60                  


Glu Trp Val Ala Phe Ile Ser Tyr Leu Thr Tyr Ser Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Gly Gly Tyr Asp Gly Tyr Pro Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  19
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR1 coding sequence

<400>  19
ggattcactt tcagtgacta cggaatggcg                                        30


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR1 sequence

<400>  20

Gly Phe Thr Phe Ser Asp Tyr Gly Met Ala 
1               5                   10  


<210>  21
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR2 coding sequence

<400>  21
tttattagtt atttgacata tagtatctac tatgcagaca ctgtgacggg c                51


<210>  22
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR2 sequence

<400>  22

Phe Ile Ser Tyr Leu Thr Tyr Ser Ile Tyr Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR3 coding sequence

<400>  23
caggggggct atgatggtta cccttactgg tacttcgatg tc                          42


<210>  24
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 heavy chain CDR3 sequence

<400>  24

Gln Gly Gly Tyr Asp Gly Tyr Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  25
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 hybridoma light chain coding sequence

<400>  25
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatttcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgcactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacatcca acctggcttc tggagtccct      240

gttcgcttca gtggcagtgg gtcttggacc tcttactctc tcacaatcag cagcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta gttacccacc cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  26
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 hybridoma light chain polypeptide sequence

<400>  26

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Met Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ser Ala Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Arg Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Trp Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  27
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR1 coding sequence

<400>  27
agtgccagct caagtgtaag ttacatgcac                                        30


<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR1 sequence

<400>  28

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR2 coding sequence

<400>  29
ctcacatcca acctggcttc t                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR2 sequence

<400>  30

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  31
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR3 coding sequence

<400>  31
cagcagtgga gtagttaccc acccacg                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.117.4 light chain CDR3 sequence

<400>  32

Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  33
<211>  411
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 hybridoma heavy chain coding sequence

<400>  33
atggaatgga gcagagtctt tatctttctc ctatcagtaa ctgcaggtgt tcactcccag       60

gtccagctgc agcagtctgg agctgagctg gtaaggcctg ggacttcagt gaaggtgtcc      120

tgcaaggctt ctggataccc cttcactagt tacttgatag actgggtaaa gcagaggcct      180

ggacagggcc ttgagtggat tggagtgatt aatcctggaa gtggtggtac taagtacaat      240

gagaagttcc agggcaaggc aacactgact gcagacaaat cctccagcac tgcctatatg      300

cagctcagca gcctgacatc tgaggactct gcggtctatt tctgtgcaag ggggggctgg      360

gacgggaagt ttacttactg gggccaaggg actctggtca ctgtctctgc a               411


<210>  34
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 hybridoma heavy chain polypeptide sequence

<400>  34

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe 
        35                  40                  45              


Thr Ser Tyr Leu Ile Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Trp Asp Gly Lys Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  35
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR1 coding sequence

<400>  35
ggatacccct tcactagtta cttgatagac                                        30


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR1 sequence

<400>  36

Gly Tyr Pro Phe Thr Ser Tyr Leu Ile Asp 
1               5                   10  


<210>  37
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR2 coding sequence

<400>  37
gtgattaatc ctggaagtgg tggtactaag tacaatgaga agttccaggg c                51


<210>  38
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR2 sequence

<400>  38

Val Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR3 coding sequence

<400>  39
gggggctggg acgggaagtt tacttac                                           27


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 heavy chain CDR3 sequence

<400>  40

Gly Gly Trp Asp Gly Lys Phe Thr Tyr 
1               5                   


<210>  41
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 hybridoma light chain coding sequence

<400>  41
atgagggctc ctgcacagat ttttggcttc ttgttgctct tgtttccagg taccagatgt       60

gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt      120

ctcacttgtc gggcaagtca ggacattggt agtagcttaa actggcttca gcaggaacca      180

gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa      240

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      300

gaagattttg tagactatta ctgtctacaa tatgctagtt ctccttacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  42
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 hybridoma light chain polypeptide sequence

<400>  42

Met Arg Ala Pro Ala Gln Ile Phe Gly Phe Leu Leu Leu Leu Phe Pro 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Ser Ser Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  43
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR1 coding sequence

<400>  43
cgggcaagtc aggacattgg tagtagctta aac                                    33


<210>  44
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR1 sequence

<400>  44

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR2 coding sequence

<400>  45
gccacatcca gtttagattc t                                                 21


<210>  46
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR2 sequence

<400>  46

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  47
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR3 coding sequence

<400>  47
ctacaatatg ctagttctcc ttacacg                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  68.104.1.31 light chain CDR3 sequence

<400>  48

Leu Gln Tyr Ala Ser Ser Pro Tyr Thr 
1               5                   


