                               SEQUENCE LISTING

<110> THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
 
<120> DIAGNOSIS AND TREATMENT OF MYCOBACTERIA INFECTIONS

<130> 5015.004PCT1

<140>
<141>

<150> 61/861,866
<151> 2013-08-02

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 365
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
            20                  25                  30          


Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile 
        35                  40                  45              


Gly Ser Glu Phe Met Ala Asp Leu Gly Asn Pro Leu Asp Leu Glu Met 
    50                  55                  60                  


Leu Cys Leu Val Thr Gly Arg Asp Phe Arg Trp Thr Ile Asp Tyr Pro 
65                  70                  75                  80  


Trp Gly Pro Gly Glu Leu Phe Leu Glu Leu Glu Thr Gly Gly Glu His 
                85                  90                  95      


Asn Ala Leu His Gln Val Tyr Val Thr Gly Ala Thr Gly Gly Thr Tyr 
            100                 105                 110         


Thr Leu Asn Val Asn Gly Thr Asn Thr Pro Ala Ile Asp Tyr Asn Asp 
        115                 120                 125             


Val Ser Glu Asn Pro Gln Gly Leu Ala Gly Asp Ile Gln Asp Ala Leu 
    130                 135                 140                 


Asp Ala Ala Val Gly Ala Gly Asn Ala Val Val His Pro Val Ser Leu 
145                 150                 155                 160 


Phe Pro Ala Trp Thr Leu Asn Phe Asn Leu Asn Ala Ser Lys Pro Leu 
                165                 170                 175     


Thr Glu Gln Leu Val Asn Thr Ile Asn Lys Ala Ala Asn Asp Phe Phe 
            180                 185                 190         


Asp Thr Phe Asp Gln Leu Leu Gly Val Asp Val Glu Met Thr Val Thr 
        195                 200                 205             


Asp Thr Leu Asn Phe Lys Leu Lys Val Thr Ser Arg Arg Ser Phe Asp 
    210                 215                 220                 


Glu Val Gly Val Val Thr Phe Ala Val Asp Val Thr Ser Gln Ala Val 
225                 230                 235                 240 


Ile Asn Phe Phe Asn Ser Val Ala Glu Leu Thr Gly Ala Val Asn Thr 
                245                 250                 255     


Val Asn Val Asp Phe Tyr Trp Asn Arg Thr Tyr Asp Ile Glu Phe Thr 
            260                 265                 270         


Gly Ser Leu Gly Leu Gln Pro Ile Pro Ala Thr Thr Ala Asp Ile Thr 
        275                 280                 285             


Asn Leu Ala Gly Thr Ser Lys Ala Val Ser Val Thr Val Val Glu Pro 
    290                 295                 300                 


Gly Lys Lys Arg Leu Thr Ile Trp Pro Phe Thr Val Asn Gly Glu Thr 
305                 310                 315                 320 


Ala Thr Ile Lys Val Glu Ser Glu Glu Ala Asp Lys Ile Pro Asn Arg 
                325                 330                 335     


Cys Arg Trp Gln Leu Val His Met Pro Thr Gly Glu Ala Ala Gly Gly 
            340                 345                 350         


Asp Ala Lys Gln Leu Gly Arg Val Tyr Arg Gln Pro Arg 
        355                 360                 365 


<210> 2
<211> 1098
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
atgcaccatc atcatcatca ttcttctggt ctggtgccac gcggttctgg tatgaaagaa       60

accgctgctg ctaaattcga acgccagcac atggacagcc cagatctggg taccgacgac      120

gacgacaagg ccatggctga tatcggatcc gaattcatgg ccgacctcgg caacccactc      180

gacctcgaga tgctctgcct ggtcacaggc cgggacttcc gctggaccat cgattacccg      240

tggggtccgg gagagctgtt cctcgaactc gagaccggcg gcgaacacaa cgcgctgcat      300

caggtctatg tcaccggggc gaccggaggc acgtacacgc tgaacgtcaa cggcaccaac      360

accccggcca tcgactacaa cgacgtgtcg gagaatccgc aggggctggc aggcgacatc      420

caagacgctc tggacgcagc cgtcggagcc ggaaacgctg tcgtgcatcc ggtctcgctg      480

ttccctgcgt ggacactgaa cttcaacctc aacgccagca agccgctcac cgagcagttg      540

gtcaacacga tcaacaaggc cgcgaacgac ttcttcgaca cgttcgacca actacttggg      600

gtcgacgtgg agatgacggt caccgacacc ctgaacttca agctcaaggt gacctcgcgg      660

cgctcgttcg atgaggtcgg tgtcgtcacg ttcgcggtcg acgtgaccag ccaggcagtc      720

atcaacttct tcaactccgt cgccgaactc accggagcgg tgaacaccgt caacgtcgac      780

ttctactgga accggacgta tgacatcgag ttcaccggat cccttgggct gcagccgatt      840

ccggctacta cagccgacat caccaacctg gcgggtacca gcaaggccgt ctcagtcacg      900

gtggtcgagc caggaaagaa gaggctgacc atctggccgt tcacggtcaa cggtgaaacc      960

gcaaccatca aggtcgagtc cgaagaggcc gacaagatcc ccaaccgctg ccgctggcag     1020

ttggttcaca tgccgaccgg cgaggcagcc ggcggcgatg caaagcagct cggccgcgtt     1080

taccgacagc cgaggtaa                                                   1098


<210> 3
<211> 344
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
            20                  25                  30          


Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile 
        35                  40                  45              


Gly Ser Glu Phe Met Thr Phe Thr Val Thr Arg Glu Arg Ala Gln Trp 
    50                  55                  60                  


Val His Asp Met Ala Arg Ala Arg Asp Gly Leu Pro Tyr Ala Tyr Gly 
65                  70                  75                  80  


Gly Ala Phe Thr Asn Asn Pro Arg Val Ser Thr Asp Cys Ser Gly Leu 
                85                  90                  95      


Val Leu Gln Thr Gly Ala Trp Tyr Gly Gly Arg Thr Asp Trp Val Gly 
            100                 105                 110         


Asn Arg Tyr Gly Ser Thr Glu Ser Phe Arg Leu Asp His Lys Ile Val 
        115                 120                 125             


Tyr Asp Leu Gly Phe Lys Arg Met Pro Arg Gly Gly Pro Ala Ala Leu 
    130                 135                 140                 


Pro Ile Lys Pro Val Met Leu Val Gly Leu Gln His Gly Gly Gly Gly 
145                 150                 155                 160 


Val Tyr Ser His Thr Ala Cys Thr Leu Met Thr Met Asp His Pro Gly 
                165                 170                 175     


Gly Pro Val Lys Met Ser Asp Arg Gly Val Asp Trp Glu Ser His Gly 
            180                 185                 190         


Asn Arg Asn Gly Val Gly Val Glu Leu Tyr Glu Gly Ala Arg Ala Trp 
        195                 200                 205             


Asn Asp Pro Leu Phe His Asp Phe Trp Tyr Leu Asp Ala Val Leu Glu 
    210                 215                 220                 


Asp Glu Gly Asp Asp Asp Glu Leu Ala Asp Pro Val Leu Gly Lys Met 
225                 230                 235                 240 


Ile Arg Glu Ile His Ala Cys Leu Phe Asn Gln Thr Ala Ser Thr Ser 
                245                 250                 255     


Asp Leu Ala Thr Pro Gly Glu Gly Ala Ile Trp Gln Leu His Gln Lys 
            260                 265                 270         


Ile His Ser Ile Asp Gly Met Leu His Pro Ile His Ala Glu Arg Arg 
        275                 280                 285             


Ala Arg Ala Gly Asp Leu Gly Glu Leu His Arg Ile Val Leu Ala Ala 
    290                 295                 300                 


Lys Gly Leu Gly Val Lys Arg Asp Glu Val Thr Lys Arg Val Tyr Gln 
305                 310                 315                 320 


Ser Ile Leu Ala Asp Ile Glu Arg Asp Asn Pro Glu Val Leu Gln Arg 
                325                 330                 335     


Tyr Ile Ala Glu Arg Gly Gly Leu 
            340                 


<210> 4
<211> 1035
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
atgcaccatc atcatcatca ttcttctggt ctggtgccac gcggttctgg tatgaaagaa       60

accgctgctg ctaaattcga acgccagcac atggacagcc cagatctggg taccgacgac      120

gacgacaagg ccatggctga tatcggatcc gaattcatga ccttcacagt cacccgcgag      180

agagcgcagt gggtccacga catggcccgc gctcgcgacg gtctccccta cgcgtacggc      240

ggggcgttca ccaacaaccc gagggtgtcg actgactgct ctggcctggt gctgcagacc      300

ggggcttggt atggaggtcg caccgactgg gtcggaaacc gttacggctc aaccgaatcg      360

ttccggctcg accacaagat cgtctacgac ctagggttca agcggatgcc ccgaggcggg      420

ccagcggcct tgccgatcaa gccggtgatg ctcgtcgggc tccagcacgg aggcggcggg      480

gtctactcgc acaccgcttg cacgttgatg acgatggacc accccggtgg cccggtcaag      540

atgtccgacc gaggcgtcga ctgggagtcc cacggcaacc gcaacggcgt aggcgtcgaa      600

ctttacgagg gcgcacgggc atggaacgac cctctgttcc atgacttttg gtacctggac      660

gcagtcctcg aagacgaagg agacgatgac gaattggctg acccagttct agggaagatg      720

atccgcgaga tccacgcgtg cctgttcaat cagaccgcgt cgaccagcga tctggcgacc      780

cctggtgaag gcgctatctg gcagctacac cagaagatcc actcgattga cggcatgctc      840

cacccgatcc acgctgagcg gcgcgctcgc gcaggcgatc tcggtgagct gcaccgaatc      900

gtgttggccg cgaagggctt gggcgtgaag cgcgacgagg tgaccaagcg ggtctaccag      960

agcatcctcg ccgacatcga gcgggacaac cccgaagtac ttcagcgata catcgcagaa     1020

agaggtggcc tatga                                                      1035


<210> 5
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
            20                  25                  30          


Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile 
        35                  40                  45              


Gly Ser Glu Phe Val Thr Tyr Pro Thr Asn Pro Leu Glu Ala Ile Gly 
    50                  55                  60                  


Ala Asp Gly Ala Phe Glu Ile Gly Gly Gly Asp Trp Ser Phe Gly Gln 
65                  70                  75                  80  


Asp Tyr Thr Glu Gln Ala Ile Arg Ala Leu Phe Thr Met Pro Ala Val 
                85                  90                  95      


Thr Met Glu Asn Ala Leu Gly Leu Leu Glu Glu His Leu Leu Lys Leu 
            100                 105                 110         


Pro Leu Glu Ala Leu Gln Gly Phe Lys Asp Met Ile Pro Asp Trp Val 
        115                 120                 125             


Glu Gly Ala Phe Asp Thr Val Thr Gly Ala Val Gln Ala Ile Met Asn 
    130                 135                 140                 


Ala Leu Gln Asp Gly Pro Leu Phe Leu Lys Phe Ala Glu Phe Gln Leu 
145                 150                 155                 160 


Phe Leu Gln Arg Leu Leu Asn Asn Pro Ala Glu Val Ile Gly Glu Ile 
                165                 170                 175     


Pro Gln Thr Leu Ile Asp Gly Leu Gln Asp Ala Leu Asn Thr Val Asn 
            180                 185                 190         


Asn Thr Ile Gln Thr Ile Val Asp Met Leu Leu Gln Ala Leu Gly Ile 
        195                 200                 205             


Thr Pro Glu Gly Glu Leu Ile Asp Arg Ile Phe Asp Leu Ser Asp Glu 
    210                 215                 220                 


Met Glu Trp Leu Gln Thr Ala Ala Ser Asn Ala Ala Thr Gly Ile Gln 
225                 230                 235                 240 


Asp Thr Trp Asn Lys Phe Trp Gly Ala Leu Thr Gly Arg Val Pro Asp 
                245                 250                 255     


Gln Asp Gln Thr Val Ala Glu Pro Ala Glu Arg Ile Gly Glu Leu Ala 
            260                 265                 270         


Gly Thr Thr Ser Ala Asn Ser Ser Ala Ile Ala Glu Leu Gln Arg Arg 
        275                 280                 285             


Leu Asp Asn Gln Gln Asn Ala Gly Gly Val Ala Gly Gly Asp Asp Phe 
    290                 295                 300                 


Glu Arg Leu Asn Ile Ser Gly Trp Asp Ile Arg Tyr Ser Asn Gly Ser 
305                 310                 315                 320 


Ser Gly Arg Gly Tyr Tyr Arg Ala Asp Gly His Gln Leu Val Trp Met 
                325                 330                 335     


Asp Glu Gly Asn Gln Gln Asn Thr Ala Thr Phe Val Arg Thr Asn Pro 
            340                 345                 350         


Ala Asp Glu Lys Thr Ala Thr Asp Tyr Gln Lys Met Thr Leu Val Val 
        355                 360                 365             


Gly Thr Ile Ser Gly Glu Val Gln Thr Val Phe Pro Pro Gln Gly Gly 
    370                 375                 380                 


Ser His Thr Arg Leu Trp Val Arg Val Asn Asp Asn Ala Pro Thr Val 
385                 390                 395                 400 


Gly Ile Thr Asp Gly Val Phe Val Glu Ile Gly Gly Val Ser Lys Ala 
                405                 410                 415     


Gln Ile Gly Tyr Arg Arg Asn Gly Asn Asp Thr Phe Val Gly Ser Met 
            420                 425                 430         


Val Asp Cys Thr Trp Gly Ala Gly Ser Ile Phe Ala Leu Thr Ala Gly 
        435                 440                 445             


Thr Ala Asn Gly Ala Glu Lys Phe Glu Val Ser Lys Asn Gly Pro Val 
    450                 455                 460                 


Leu Ala Thr Trp Ser Asp Asp Gly Val Val Ser Ala Met Gly Ala Asn 
465                 470                 475                 480 


Tyr Arg Arg Trp Gly Trp Glu Gly Gln Ala Arg Asn Arg Asn Leu Gly 
                485                 490                 495     


Gln Gly Thr Pro Asn Ser Val Thr Arg Val Thr Ile Thr Asp Asn Asp 
            500                 505                 510         


Pro Thr Gly Ala Gly Gly Gly Ala Val Asn Val Gly Gly Asp Val Val 
        515                 520                 525             


Gly Val Leu Pro Ile Glu Asn Gly Gly Thr Gly Ala Ser Thr Ala Ser 
    530                 535                 540                 


Ala Ala Arg Thr Ala Leu Gly Ile Asp Asp Leu Val Glu Asp Met Ser 
545                 550                 555                 560 


Asp Val Val Arg Gly Ser Val Glu Gly Leu Pro Leu Ile Pro Lys Ile 
                565                 570                 575     


Trp Val Gly Thr Glu Ala Gln Tyr Thr Ala Leu Ala Thr Lys Asp Gln 
            580                 585                 590         


Ser Thr Leu Tyr Phe Arg Thr Ala 
        595                 600 


<210> 6
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
atgcaccatc atcatcatca ttcttctggt ctggtgccac gcggttctgg tatgaaagaa       60

accgctgctg ctaaattcga acgccagcac atggacagcc cagatctggg taccgacgac      120

gacgacaagg ccatggctga tatcggatcc gaattcgtga cctaccccac caacccacta      180

gaggccatcg gcgctgacgg cgcattcgag atcggtgggg gcgactggag cttcggccag      240

gactacaccg aacaggccat ccgggctctg ttcacgatgc cagcggtcac gatggagaac      300

gctctcggcc tgctcgaaga gcacctgctg aagctgcctc tggaggcgct gcagggcttc      360

aaagacatga tcccggactg ggtcgaagga gcattcgaca cggtcaccgg cgctgtgcag      420

gcgatcatga acgcgctcca agacggcccg ctgttcctga agttcgccga gttccagctc      480

ttcctgcagc gtctgctgaa caacccggcc gaggtcatcg gcgagatccc ccagacgttg      540

atcgacggcc tacaggacgc gctcaacacc gtcaacaaca ccatccagac catcgtggac      600

atgctcctgc aggcgctggg catcaccccg gagggggagc tgatcgaccg gatcttcgac      660

ctgagcgatg agatggagtg gctgcagacc gcagcctcga atgcagctac cggcatccag      720

gacacctgga acaagttctg gggagccctc accgggcgcg tcccagacca ggaccagacc      780

gtcgctgagc ccgccgagcg tatcggcgag ctggccggca ccacgtctgc taactcgtct      840

gccatcgcgg agctgcagcg tcgactggac aaccagcaga acgctggcgg cgtggccggc      900

ggtgacgact tcgagcgact gaacatatcc ggttgggaca tcaggtattc caacggatcc      960

agcggccgag ggtactaccg tgccgacggc caccaactgg tctggatgga cgaaggcaac     1020

cagcagaaca ccgcgacgtt cgtccgcacc aaccccgcag acgagaagac agccaccgac     1080

taccagaaga tgacgttggt cgtcgggact atctccggtg aggtacagac cgtgttcccg     1140

ccgcagggag gttcgcacac ccggctatgg gtccgcgtca acgacaacgc tccgaccgtc     1200

ggcatcaccg acggcgtgtt cgtagagatc ggcggcgtat cgaaggccca gatcggctac     1260

cgccgcaacg gcaatgacac gttcgtcgga tctatggtcg actgcacctg gggtgctgga     1320

tcgatcttcg ctctgaccgc cggcacggcc aacggtgctg agaagttcga ggtctcgaag     1380

aacggccccg tgctggccac atggtcggac gacggcgtcg tctccgcgat gggtgcgaac     1440

taccgccgct ggggctggga aggccaggct cgtaaccgca acctcggcca gggcactccg     1500

aactcggtca cccgagtgac gatcaccgac aacgatccta ccggcgcagg cggtggagct     1560

gtcaacgtcg gaggagatgt cgtaggtgta ctccccatag agaacggagg caccggagct     1620

tcgacagctt cggcagcccg taccgctctc ggaatcgatg acctggtcga agatatgtcc     1680

gacgtagttc gtggatccgt cgaaggactc ccgttgatac cgaagatctg ggtaggaaca     1740

gaagctcagt acacggctct cgccaccaag gatcagtcca cgctatactt caggaccgct     1800

taa                                                                   1803


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 7
tgacggttac ggaggtggtt                                                   20


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 8
cggtccagtt cgctgtcat                                                    19


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 9
atgcagtaat ggtcggcctt a                                                 21


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 10
cacgcaggca ttccaagtc                                                    19


<210> 11
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 11
tggcacaacc tgtctg                                                       16


<210> 12
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 12
acgggaaggg tggtc                                                        15


<210> 13
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 13
ggcatcgaat tcatggccga cctcggcaac ccactcg                                37


<210> 14
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 14
gatgctaagc ttttacctcg gctgtcggta aacgcggc                               38


<210> 15
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 15
ggcatcgaat tcatgacctt cacagtcacc cgcgag                                 36


<210> 16
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 16
gatgctaagc tttcataggc cacctctttc tgcgatg                                37


<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 17
His His His His His His 
1               5       


