                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Novel selection vectors and methods of selecting eukaryotic host 
       cells

<130>  PAT055303-WO-PCT

<150>  US 61/860,439
<151>  2013-07-31

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  1

Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys 
1               5                   10                  15      


His His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys 
            20                  25                  30          


Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu 
        35                  40                  45              


Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys 
    50                  55                  60                  


Gly Glu Met Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys 
65                  70                  75                  80  


Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp 
                85                  90                  95      


Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu 
            100                 105                 110         


Asp Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys 
        115                 120                 125             


Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys 
    130                 135                 140                 


Ala Val Gly Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro 
145                 150                 155                 160 


Thr Val Leu Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn 
                165                 170                 175     


Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala 
            180                 185                 190         


Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
        195                 200                 205 


<210>  2
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ala Met Ser Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu 
1               5                   10                  15      


Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser 
            20                  25          


<210>  3
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met Asp Ala Lys His His 
1               5                   10                  15      


Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His Asp Gln Cys Ser Pro 
            20                  25                  30          


Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His 
        35                  40                  45              


Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys 
    50                  55                  60                  


Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr 
65                  70                  75                  80  


Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asn Gln Thr 
                85                  90                  95      


Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu Cys Lys Glu Asp Cys 
            100                 105                 110         


Gln Arg Trp Trp Glu Asp Cys His Thr Ser His Thr Cys Lys Ser Asn 
        115                 120                 125             


Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val Asn Lys Cys Pro Ala 
    130                 135                 140                 


Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe Pro Thr Pro Ala Ala 
145                 150                 155                 160 


Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys Val Ser Asn Tyr Ser 
                165                 170                 175     


Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Ser Ala Gln Gly 
            180                 185                 190         


Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
        195                 200             


<210>  5
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
1               5                   10                  15      


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
            20                  25                  30      


<210>  6
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Thr Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  7
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp Leu Leu Asn Val Cys Met 
1               5                   10                  15      


Asn Ala Lys His His Lys Thr Gln Pro Ser Pro Glu Asp Glu Leu Tyr 
            20                  25                  30          


Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
        35                  40                  45              


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
    50                  55                  60                  


Asp His Cys Gly Lys Met Glu Pro Thr Cys Lys Arg His Phe Ile Gln 
65                  70                  75                  80  


Asp Ser Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Arg 
                85                  90                  95      


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Ile Leu Asn Val Pro Leu 
            100                 105                 110         


Cys Lys Glu Asp Cys Glu Arg Trp Trp Glu Asp Cys Arg Thr Ser Tyr 
        115                 120                 125             


Thr Cys Lys Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Ile 
    130                 135                 140                 


Asn Glu Cys Pro Ala Gly Ala Leu Cys Ser Thr Phe Glu Ser Tyr Phe 
145                 150                 155                 160 


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Phe Lys 
                165                 170                 175     


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
            180                 185                 190         


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Lys Phe Tyr Ala 
        195                 200                 205             


Ala Ala Met Asn Ala Gly Ala Pro Ser Arg Gly Ile Ile Asp Ser 
    210                 215                 220             


<210>  8
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser 
        35                  40                  45              


Pro Glu Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala 
    50                  55                  60                  


Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg 
65                  70                  75                  80  


Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Thr Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Ser Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Arg Gln Val Asn Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Ile Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Arg Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Ile Asn Glu Cys Pro Ala Gly Ala Leu Cys Ser 
                165                 170                 175     


Thr Phe Glu Ser Tyr Phe Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu 
            180                 185                 190         


Trp Ser His Ser Phe Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Lys Phe Tyr Ala Ala Ala Met Asn Ala Gly Ala Pro Ser Arg 
225                 230                 235                 240 


Gly Ile Ile Asp Ser 
                245 


<210>  9
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Mature mutated folate receptor


<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is any amino acid except Ala

<400>  9

Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys 
1               5                   10                  15      


His His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys 
            20                  25                  30          


Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu 
        35                  40                  45              


Xaa His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys 
    50                  55                  60                  


Gly Glu Met Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys 
65                  70                  75                  80  


Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp 
                85                  90                  95      


Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu 
            100                 105                 110         


Asp Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys 
        115                 120                 125             


Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys 
    130                 135                 140                 


Ala Val Gly Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro 
145                 150                 155                 160 


Thr Val Leu Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn 
                165                 170                 175     


Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala 
            180                 185                 190         


Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
        195                 200                 205 


<210>  10
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg 
            20                  25  


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala 
            20      


<210>  12
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala 
            20          


<210>  13
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated folate receptor

<400>  13

Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys 
1               5                   10                  15      


His His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys 
            20                  25                  30          


Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu 
        35                  40                  45              


Leu His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys 
    50                  55                  60                  


Gly Glu Met Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys 
65                  70                  75                  80  


Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp 
                85                  90                  95      


Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu 
            100                 105                 110         


Asp Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys 
        115                 120                 125             


Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys 
    130                 135                 140                 


Ala Val Gly Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro 
145                 150                 155                 160 


Thr Val Leu Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn 
                165                 170                 175     


Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala 
            180                 185                 190         


Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala Ala Ala Met 
        195                 200                 205             


Ser Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Met Leu Leu Trp Leu Leu Ser 
225                 230         


