                         SEQUENCE LISTING

<110>  PIERRE FABRE DERMO-COSMETIQUE
 
<120>  Ractif de stimulation, substitut cutan, explant cutan et procd pour reproduire la physiopathologie de la dermatite atopique

<130>  366011 D32691

<150>  FR1357608
<151>  2013-07-31

<150>  FR1361788
<151>  2013-11-28

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  269
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL1beta

<400>  1

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  2
<211>  159
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TSLP

<400>  2

Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser Val Ser Phe Arg Lys 
1               5                   10                  15      


Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu Thr Tyr Asp Phe Thr 
            20                  25                  30          


Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu Ser Thr Ile Ser 
        35                  40                  45              


Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser Thr Glu Phe Asn 
    50                  55                  60                  


Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu Thr Glu Ile Gln 
65                  70                  75                  80  


Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser Leu Ala Lys Glu 
                85                  90                  95      


Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile Trp Cys Pro Gly 
            100                 105                 110         


Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met Lys Lys Arg Arg 
        115                 120                 125             


Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln Val Ser Gln Leu 
    130                 135                 140                 


Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu Lys Gln Gln 
145                 150                 155                 


<210>  3
<211>  91
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  RANTES

<400>  3

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  4
<211>  99
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  MCP3

<400>  4

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 
            20                  25                  30          


Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 
                85                  90                  95      


Pro Lys Leu 
            


<210>  5
<211>  212
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-6

<400>  5

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  6
<211>  99
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-8

<400>  6

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  7
<211>  4061
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  filaggrine

<400>  7

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210>  8
<211>  211
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  claudine 1

<400>  8

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  9
<211>  784
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TLR2

<400>  9

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  10
<211>  904
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TLR3

<400>  10

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


=