                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  Lipopetides for use in treating liver diseases and cardiovascular
        diseases

<130>  U30578WO

<150>  US 61/859,476
<151>  2013-07-29

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Essential domain


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Asn Pro Leu Gly Phe Xaa Pro 
1               5           


<210>  2
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  2

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile 
        35                  40                  45              


Lys Asp His Trp Pro Gln Ala Asn Gln Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Val Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Ala Thr Val Pro Ala Met Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Ser His Pro Gln Ala 
        115                 


<210>  3
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  3

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Lys Ala Asn Ser Glu Asn Pro Asp Trp Asp Leu Asn Pro His 
        35                  40                  45              


Lys Asp Asn Trp Pro Asp Ala His Lys Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Ser Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  4
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  4

Met Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Lys Ala Asn Ser Glu Asn Pro Asp Trp Asp Leu Asn Pro His 
        35                  40                  45              


Lys Asp Asn Trp Pro Asp Ala His Lys Val Gly Val Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Ser Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  5
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  5

Met Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Glu 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Lys Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Lys Lys Asp Tyr Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45              


Ala Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Leu Pro Ala Asn 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro 
                85                  90                  95      


Leu Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  6
<211>  107
<212>  PRT
<213>  Hepatitis B virus

<400>  6

Met Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        35                  40                  45              


Ala Gly Ala Phe Gly Leu Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Phe Gln Thr Leu Pro Ala Asn Pro 
65                  70                  75                  80  


Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Leu 
                85                  90                  95      


Ser Pro Pro Leu Arg Thr Thr His Pro Gln Ala 
            100                 105         


<210>  7
<211>  118
<212>  PRT
<213>  Hepatitis B virus

<400>  7

Met Gly Leu Ser Trp Thr Val Pro Leu Glu Trp Gly Lys Asn Ile Ser 
1               5                   10                  15      


Thr Thr Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Arg Ala Asn Thr Arg Asn Pro Asp Trp Asp His Asn Pro Asn Lys 
        35                  40                  45              


Asp His Trp Thr Glu Ala Asn Lys Val Gly Val Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala 
65                  70                  75                  80  


Gln Gly Met Leu Lys Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Thr Pro Pro Leu Arg 
            100                 105                 110         


Asp Thr His Pro Gln Ala 
        115             


<210>  8
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  8

Met Gly Ala Pro Leu Ser Thr Thr Arg Arg Gly Met Gly Gln Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Leu Phe Arg Ala Asn Ser Ser Ser Pro Asp Trp Asp Phe Asn Thr Asn 
        35                  40                  45              


Lys Asp Ser Trp Pro Met Ala Asn Lys Val Gly Val Gly Gly Tyr Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Val Leu Thr Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Arg Ser Gly Arg Lys Pro Thr Pro Val Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  9
<211>  118
<212>  PRT
<213>  Hepatitis B virus

<400>  9

Met Gly Leu Ser Trp Thr Val Pro Leu Glu Trp Gly Lys Asn Leu Ser 
1               5                   10                  15      


Ala Ser Asn Pro Leu Gly Phe Leu Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp Asp Phe Asn Pro Lys Lys 
        35                  40                  45              


Asp Pro Trp Pro Glu Ala Asn Lys Val Gly Val Gly Ala Tyr Gly Pro 
    50                  55                  60                  


Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ser 
65                  70                  75                  80  


Gln Gly Thr Leu Thr Thr Leu Pro Ala Asp Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Ser His Pro Gln Ala 
        115             


<210>  10
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  10

Met Gly Gln Asn His Ser Val Thr Asn Pro Leu Gly Phe Phe Pro Asp 
1               5                   10                  15      


His Gln Leu Asp Pro Leu Phe Arg Ala Asn Ser Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Glu Ala Thr Lys Val Gly 
        35                  40                  45              


Val Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Leu Pro Ala Ala 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Lys Ala Thr Pro 
                85                  90                  95      


Ile Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  11
<211>  119
<212>  PRT
<213>  Hepatitis B virus

<400>  11

Met Gly Ala Pro Leu Ser Thr Ala Arg Arg Gly Met Gly Gln Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Leu Phe Arg Ala Asn Ser Ser Ser Pro Asp Trp Asp Phe Asn Thr Asn 
        35                  40                  45              


Lys Asp Asn Trp Pro Met Ala Asn Lys Val Gly Val Gly Gly Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Thr Ser Pro Pro Asp Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Arg Ser Gly Arg Lys Pro Thr Pro Val Ser Pro Pro Leu 
            100                 105                 110         


Arg Asp Thr His Pro Gln Ala 
        115                 


<210>  12
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  12

Met Gly Gln Asn Leu Ser Val Ser Asn Pro Leu Gly Phe Phe Pro Glu 
1               5                   10                  15      


His Gln Leu Asp Pro Leu Phe Arg Ala Asn Thr Asn Asn Pro Asp Trp 
            20                  25                  30          


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Glu Ala Thr Lys Val Gly 
        35                  40                  45              


Val Gly Ala Phe Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu 
    50                  55                  60                  


Gly Trp Ser Pro Gln Ala Gln Gly Val Thr Thr Ile Leu Pro Ala Val 
65                  70                  75                  80  


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro 
                85                  90                  95      


Ile Ser Pro Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105             


<210>  13
<211>  105
<212>  PRT
<213>  Hepatitis B virus

<400>  13

Met Gly Leu Asn Gln Ser Thr Phe Pro Leu Gly Phe Phe Pro Ser His 
1               5                   10                  15      


Gln Leu Asp Pro Leu Phe Lys Ala Asn Ala Gly Ser Ala Asp Trp Asp 
            20                  25                  30          


Lys Pro Lys Asp Pro Trp Pro Gln Ala His Asp Thr Ala Val Gly Ala 
        35                  40                  45              


Phe Gly Pro Gly Leu Val Pro Pro His Gly Gly Leu Leu Gly Trp Ser 
    50                  55                  60                  


Ser Gln Ala Gln Gly Leu Ser Val Thr Val Pro Asp Thr Pro Pro Pro 
65                  70                  75                  80  


Pro Ser Thr Asn Arg Asp Lys Gly Arg Lys Pro Thr Pro Ala Thr Pro 
                85                  90                  95      


Pro Leu Arg Asp Thr His Pro Gln Ala 
            100                 105 


<210>  14
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence

<400>  14

Met Gly Gly Trp Ser Ser Thr Pro Arg Lys Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Arg Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
        35                  40                  45              


Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
    50                  55                  


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal sequence X


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Asn Xaa Ser Xaa Xaa 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal sequence Y


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Xaa His Gln Leu Asp Pro 
1               5       


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preferred amino acid sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Asn Xaa Ser Xaa Xaa Asn Pro Leu Gly Phe Xaa Pro Xaa His Gln Leu 
1               5                   10                  15      


Asp Pro 
        


<210>  18
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV preS/2-48 (genotype C)

<400>  18

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  19
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV preS/2-48 (genotype D)

<400>  19

Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  20
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBV preS/2-48 (consensus)

<400>  20

Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  21
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant MyrBAla11-15

<400>  21

Gly Thr Asn Leu Ser Val Pro Asn Pro Ala Ala Ala Ala Ala Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp His Trp Pro Glu Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  22
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preS2-78myr

<400>  22

Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ala 
        35                  40                  45              


Gly Ala Phe Gly Leu Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly 
    50                  55                  60                  


Trp Ser Pro Gln Ala Gln Gly Ile Leu Gln Thr Leu Pro 
65                  70                  75          


<210>  23
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Ala His Asn Ala Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Lys Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Ile Phe 
    290                 295                 300                 


Trp Cys Tyr Glu Lys Phe Lys Thr Pro Lys Asp Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210>  24
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Leu Cys Ser Thr Ile Leu Asn Val Ala Phe Pro Pro Glu Val Ile 
1               5                   10                  15      


Gly Pro Leu Phe Phe Phe Pro Leu Leu Tyr Met 
            20                  25          


<210>  25
<211>  349
<212>  PRT
<213>  Pan troglodytes (Chimpanzee)

<400>  25

Met Glu Ala His Asn Val Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Lys Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Met Phe 
    290                 295                 300                 


Trp Cys Tyr Glu Lys Phe Lys Thr Pro Lys Asp Lys Thr Lys Met Thr 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210>  26
<211>  349
<212>  PRT
<213>  Pongo pygmaeus

<400>  26

Met Glu Ala His Asn Ala Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Lys Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Arg Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Met Phe 
    290                 295                 300                 


Trp Cys Tyr Glu Lys Phe Lys Thr Pro Lys Gly Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210>  27
<211>  349
<212>  PRT
<213>  Tupaia belangeri

<400>  27

Met Glu Ala His Asn Leu Ser Ala Pro Leu Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Gln Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Val Met Leu Leu Ile Met Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Phe Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Leu Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Ala Leu Gly 
65                  70                  75                  80  


Lys Val Phe Pro Leu Asn Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Phe Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Lys Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Val Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Ile Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Phe Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Val Pro Tyr Val Thr Lys Ala Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Leu Ser Val Ala Ile Thr Val Leu Ser Val Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Val Met Thr Pro His Leu Leu Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Ile Leu 
225                 230                 235                 240 


Ser Thr Leu Phe Arg Leu Asn Ala Gln Cys Ser Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Thr Phe Arg Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Ile Tyr 
    290                 295                 300                 


Arg Cys Tyr Glu Lys Ile Lys Pro Ser Lys Asp Lys Thr Lys Val Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Lys Thr Glu Glu Thr Ile Pro Gly Thr Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Glu Cys Ser Pro Gly Thr Ala 
            340                 345                 


<210>  28
<211>  362
<212>  PRT
<213>  Mus musculus

<400>  28

Met Glu Ala His Asn Val Ser Ala Pro Phe Asn Phe Ser Leu Pro Pro 
1               5                   10                  15      


Gly Phe Gly His Arg Ala Thr Asp Thr Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Val Met Leu Leu Leu Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Phe Trp Lys Pro Lys Gly Val Ile Ile Ala 
    50                  55                  60                  


Ile Val Ala Gln Tyr Gly Ile Met Pro Leu Ser Ala Phe Leu Leu Gly 
65                  70                  75                  80  


Lys Val Phe His Leu Thr Ser Ile Glu Ala Leu Ala Ile Leu Ile Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Leu Phe Thr Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Ser Phe 
        115                 120                 125             


Thr Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Lys Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Met 
145                 150                 155                 160 


Leu Ser Leu Val Met Val Leu Ile Pro Cys Ala Ile Gly Ile Phe Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro His Tyr Val Pro Tyr Val Leu Lys Ala Gly Met 
            180                 185                 190         


Ile Ile Thr Phe Ser Leu Ser Val Ala Val Thr Val Leu Ser Val Ile 
        195                 200                 205             


Asn Val Gly Asn Ser Ile Met Phe Val Met Thr Pro His Leu Leu Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Thr Gly Phe Leu Met Gly Tyr Ile Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Arg Leu Asn Pro Ser Cys Arg Arg Thr Ile Ser Met 
                245                 250                 255     


Glu Thr Gly Phe Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Thr Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Ala Glu Gly Leu Leu Phe Ile Ile Ile Phe 
    290                 295                 300                 


Arg Cys Tyr Leu Lys Ile Lys Pro Gln Lys Asp Gln Thr Lys Ile Thr 
305                 310                 315                 320 


Tyr Lys Ala Ala Ala Thr Glu Asp Ala Thr Pro Ala Ala Leu Glu Lys 
                325                 330                 335     


Gly Thr His Asn Gly Asn Asn Pro Pro Thr Gln Pro Gly Leu Ser Pro 
            340                 345                 350         


Asn Gly Leu Asn Ser Gly Gln Met Ala Asn 
        355                 360         


<210>  29
<211>  362
<212>  PRT
<213>  Rattus norvegicus

<400>  29

Met Glu Val His Asn Val Ser Ala Pro Phe Asn Phe Ser Leu Pro Pro 
1               5                   10                  15      


Gly Phe Gly His Arg Ala Thr Asp Lys Ala Leu Ser Ile Ile Leu Val 
            20                  25                  30          


Leu Met Leu Leu Leu Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Val Ile Val Ala 
    50                  55                  60                  


Leu Val Ala Gln Phe Gly Ile Met Pro Leu Ala Ala Phe Leu Leu Gly 
65                  70                  75                  80  


Lys Ile Phe His Leu Ser Asn Ile Glu Ala Leu Ala Ile Leu Ile Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Leu Phe Thr Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Ser Phe 
        115                 120                 125             


Ser Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Val Tyr Ser Lys Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Met 
145                 150                 155                 160 


Ile Ser Leu Val Ile Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro His Tyr Val Pro Tyr Ile Leu Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Thr Phe Leu Leu Ser Val Ala Val Thr Ala Leu Ser Val Ile 
        195                 200                 205             


Asn Val Gly Asn Ser Ile Met Phe Val Met Thr Pro His Leu Leu Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ser Gly Phe Leu Met Gly Tyr Ile Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Gln Leu Asn Pro Ser Cys Arg Arg Thr Ile Ser Met 
                245                 250                 255     


Glu Thr Gly Phe Gln Asn Ile Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Thr Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Ala Glu Gly Leu Leu Ile Ile Ile Ile Phe 
    290                 295                 300                 


Arg Cys Tyr Glu Lys Ile Lys Pro Pro Lys Asp Gln Thr Lys Ile Thr 
305                 310                 315                 320 


Tyr Lys Ala Ala Ala Thr Glu Asp Ala Thr Pro Ala Ala Leu Glu Lys 
                325                 330                 335     


Gly Thr His Asn Gly Asn Ile Pro Pro Leu Gln Pro Gly Pro Ser Pro 
            340                 345                 350         


Asn Gly Leu Asn Ser Gly Gln Met Ala Asn 
        355                 360         


<210>  30
<211>  392
<212>  PRT
<213>  Canis familiaris

<400>  30

Met Asp Ala Pro Asn Ile Thr Ala Pro Leu Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Lys Ala Leu Ser Ile Ile Leu Val 
            20                  25                  30          


Phe Leu Leu Leu Ile Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Phe Trp Lys Pro Lys Gly Leu Val Ile Ala 
    50                  55                  60                  


Leu Ile Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Thr Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Asn Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Thr Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Phe Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Asn Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Val 
145                 150                 155                 160 


Ser Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Phe Leu 
                165                 170                 175     


Lys Ala Lys Arg Pro Gln Tyr Val Arg Tyr Ile Lys Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Met Leu Leu Leu Ser Val Ala Ile Thr Ala Leu Ser Val Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Arg Phe Val Met Thr Pro His Leu Leu Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Ile Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Arg Leu Asp Gly Arg Cys Ser Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Thr Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Val Phe Leu Ile Ser Ile Phe 
    290                 295                 300                 


Arg Cys Tyr Glu Lys Ile Lys Pro Ser Lys Asp Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Ala Thr Glu Glu Ile Thr Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr His Lys Gly Glu Glu Cys Ser Pro Cys Thr Ala Ala Pro Ser 
            340                 345                 350         


Pro Ser Gly Leu Asp Ser Gly Glu Lys Ala Ile Gln Cys Asp Gln Leu 
        355                 360                 365             


Glu Lys Ala Lys Asp Lys Arg Asn Thr Lys Glu Glu Ser Phe Ser Ser 
    370                 375                 380                 


Ile Gly Ser Ser Asn Tyr Gln Asn 
385                 390         


<210>  31
<211>  349
<212>  PRT
<213>  Macaca fascicularis

<400>  31

Met Glu Ala His Asn Ala Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Ile Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Val Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Gln Leu Asn Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Leu Tyr Thr Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Gly Arg Ile Ile 
145                 150                 155                 160 


Leu Ser Leu Val Pro Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Met Phe 
    290                 295                 300                 


Arg Cys Tyr Glu Lys Phe Lys Thr Pro Lys Asp Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210>  32
<211>  352
<212>  PRT
<213>  Sus scrofa

<400>  32

Met Glu Ala Leu Asn Glu Ser Ala Pro Ile Asn Phe Thr Leu Pro His 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Leu Ile Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Gly Arg Ile Arg Ala His Phe Arg Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Ala Leu Gly 
65                  70                  75                  80  


Lys Leu Phe Arg Leu Asn Asn Val Glu Ala Leu Ala Ile Leu Ile Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Ile Phe Ala Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Met Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Leu Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Leu Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Thr Leu Lys Asp Lys Val Pro Tyr Gly Ser Ile Val 
145                 150                 155                 160 


Ile Ser Leu Ile Leu Ile Leu Ile Pro Cys Thr Ile Gly Ile Ile Leu 
                165                 170                 175     


Asn Thr Lys Arg Pro Gln Tyr Val Arg Tyr Val Ile Lys Gly Gly Thr 
            180                 185                 190         


Ile Leu Leu Ile Leu Cys Ala Ile Ala Val Thr Val Leu Ser Val Leu 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Leu Phe Val Met Thr Pro His Leu Val Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Thr Gly Phe Leu Leu Gly Tyr Leu Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Arg Leu Asn Ala Arg Cys Ser Arg Thr Val Cys Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Thr Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Leu Phe Gln Leu Gly Glu Gly Leu Leu Phe Ile Ala Ile Phe 
    290                 295                 300                 


Arg Cys Tyr Glu Lys Thr Lys Leu Ser Lys Asp Lys Met Lys Thr Ile 
305                 310                 315                 320 


Ser Ala Ala Asp Ser Thr Glu Glu Thr Ile Pro Thr Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr His Lys Gly Glu Glu Cys Pro Pro Thr Gln Pro Ser Val Val 
            340                 345                 350         


