                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> AGENTS AND METHODS FOR INHIBITING MIR-148A FOR THE MODULATION OF 
      CHOLESTEROL LEVELS

<130> 030258-078802-PCT

<140>
<141>

<150> 61/865,327
<151> 2013-08-13

<150> 61/857,948
<151> 2013-07-24

<160> 29    

<170> PatentIn version 3.5

<210> 1
<211> 68
<212> RNA
<213> Homo sapiens

<400> 1
gaggcaaagu ucugagacac uccgacucug aguaugauag aagucagugc acuacagaac       60

uuugucuc                                                                68


<210> 2
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2
ucagugcacu acagaacuuu gu                                                22


<210> 3
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2) 
<223> LNA nucleotide

<220>
<221> modified_base
<222> (4)..(5) 
<223> LNA nucleotide

<220>
<221> modified_base
<222> (9)..(9) 
<223> LNA nucleotide

<220>
<221> modified_base
<222> (12)..(12) 
<223> LNA nucleotide

<220>
<221> modified_base
<222> (14)..(15) 
<223> LNA nucleotide

<220>
<221> misc_feature
<222> (1)..(15) 
<223> Phosphorothioate linkage

<400> 3
ttctgtagtg cactg                                                        15


<210> 4
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
acaaagttct gtagtgcact gt                                                22


<210> 5
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ttctgtagtg cactg                                                        15


<210> 6
<211> 5292
<212> DNA
<213> Homo sapiens

<400> 6
ctcttgcagt gaggtgaaga catttgaaaa tcaccccact gcaaactcct ccccctgcta       60

gaaacctcac attgaaatgc tgtaaatgac gtgggccccg agtgcaatcg cgggaagcca      120

gggtttccag ctaggacaca gcaggtcgtg atccgggtcg ggacactgcc tggcagaggc      180

tgcgagcatg gggccctggg gctggaaatt gcgctggacc gtcgccttgc tcctcgccgc      240

ggcggggact gcagtgggcg acagatgcga aagaaacgag ttccagtgcc aagacgggaa      300

atgcatctcc tacaagtggg tctgcgatgg cagcgctgag tgccaggatg gctctgatga      360

gtcccaggag acgtgcttgt ctgtcacctg caaatccggg gacttcagct gtgggggccg      420

tgtcaaccgc tgcattcctc agttctggag gtgcgatggc caagtggact gcgacaacgg      480

ctcagacgag caaggctgtc cccccaagac gtgctcccag gacgagtttc gctgccacga      540

tgggaagtgc atctctcggc agttcgtctg tgactcagac cgggactgct tggacggctc      600

agacgaggcc tcctgcccgg tgctcacctg tggtcccgcc agcttccagt gcaacagctc      660

cacctgcatc ccccagctgt gggcctgcga caacgacccc gactgcgaag atggctcgga      720

tgagtggccg cagcgctgta ggggtcttta cgtgttccaa ggggacagta gcccctgctc      780

ggccttcgag ttccactgcc taagtggcga gtgcatccac tccagctggc gctgtgatgg      840

tggccccgac tgcaaggaca aatctgacga ggaaaactgc gctgtggcca cctgtcgccc      900

tgacgaattc cagtgctctg atggaaactg catccatggc agccggcagt gtgaccggga      960

atatgactgc aaggacatga gcgatgaagt tggctgcgtt aatgtgacac tctgcgaggg     1020

acccaacaag ttcaagtgtc acagcggcga atgcatcacc ctggacaaag tctgcaacat     1080

ggctagagac tgccgggact ggtcagatga acccatcaaa gagtgcggga ccaacgaatg     1140

cttggacaac aacggcggct gttcccacgt ctgcaatgac cttaagatcg gctacgagtg     1200

cctgtgcccc gacggcttcc agctggtggc ccagcgaaga tgcgaagata tcgatgagtg     1260

tcaggatccc gacacctgca gccagctctg cgtgaacctg gagggtggct acaagtgcca     1320

gtgtgaggaa ggcttccagc tggaccccca cacgaaggcc tgcaaggctg tgggctccat     1380

cgcctacctc ttcttcacca accggcacga ggtcaggaag atgacgctgg accggagcga     1440

gtacaccagc ctcatcccca acctgaggaa cgtggtcgct ctggacacgg aggtggccag     1500

caatagaatc tactggtctg acctgtccca gagaatgatc tgcagcaccc agcttgacag     1560

agcccacggc gtctcttcct atgacaccgt catcagcaga gacatccagg cccccgacgg     1620

gctggctgtg gactggatcc acagcaacat ctactggacc gactctgtcc tgggcactgt     1680

ctctgttgcg gataccaagg gcgtgaagag gaaaacgtta ttcagggaga acggctccaa     1740

gccaagggcc atcgtggtgg atcctgttca tggcttcatg tactggactg actggggaac     1800

tcccgccaag atcaagaaag ggggcctgaa tggtgtggac atctactcgc tggtgactga     1860

aaacattcag tggcccaatg gcatcaccct agatctcctc agtggccgcc tctactgggt     1920

tgactccaaa cttcactcca tctcaagcat cgatgtcaac gggggcaacc ggaagaccat     1980

cttggaggat gaaaagaggc tggcccaccc cttctccttg gccgtctttg aggacaaagt     2040

attttggaca gatatcatca acgaagccat tttcagtgcc aaccgcctca caggttccga     2100

tgtcaacttg ttggctgaaa acctactgtc cccagaggat atggttctct tccacaacct     2160

cacccagcca agaggagtga actggtgtga gaggaccacc ctgagcaatg gcggctgcca     2220

gtatctgtgc ctccctgccc cgcagatcaa cccccactcg cccaagttta cctgcgcctg     2280

cccggacggc atgctgctgg ccagggacat gaggagctgc ctcacagagg ctgaggctgc     2340

agtggccacc caggagacat ccaccgtcag gctaaaggtc agctccacag ccgtaaggac     2400

acagcacaca accacccgac ctgttcccga cacctcccgg ctgcctgggg ccacccctgg     2460

gctcaccacg gtggagatag tgacaatgtc tcaccaagct ctgggcgacg ttgctggcag     2520

aggaaatgag aagaagccca gtagcgtgag ggctctgtcc attgtcctcc ccatcgtgct     2580

cctcgtcttc ctttgcctgg gggtcttcct tctatggaag aactggcggc ttaagaacat     2640

caacagcatc aactttgaca accccgtcta tcagaagacc acagaggatg aggtccacat     2700

ttgccacaac caggacggct acagctaccc ctcgagacag atggtcagtc tggaggatga     2760

cgtggcgtga acatctgcct ggagtcccgt ccctgcccag aacccttcct gagacctcgc     2820

cggccttgtt ttattcaaag acagagaaga ccaaagcatt gcctgccaga gctttgtttt     2880

atatatttat tcatctggga ggcagaacag gcttcggaca gtgcccatgc aatggcttgg     2940

gttgggattt tggtttcttc ctttcctcgt gaaggataag agaaacaggc ccggggggac     3000

caggatgaca cctccatttc tctccaggaa gttttgagtt tctctccacc gtgacacaat     3060

cctcaaacat ggaagatgaa aggggagggg atgtcaggcc cagagaagca agtggctttc     3120

aacacacaac agcagatggc accaacggga ccccctggcc ctgcctcatc caccaatctc     3180

taagccaaac ccctaaactc aggagtcaac gtgtttacct cttctatgca agccttgcta     3240

gacagccagg ttagcctttg ccctgtcacc cccgaatcat gacccaccca gtgtctttcg     3300

aggtgggttt gtaccttcct taagccagga aagggattca tggcgtcgga aatgatctgg     3360

ctgaatccgt ggtggcaccg agaccaaact cattcaccaa atgatgccac ttcccagagg     3420

cagagcctga gtcactggtc acccttaata tttattaagt gcctgagaca cccggttacc     3480

ttggccgtga ggacacgtgg cctgcaccca ggtgtggctg tcaggacacc agcctggtgc     3540

ccatcctccc gacccctacc cacttccatt cccgtggtct ccttgcactt tctcagttca     3600

gagttgtaca ctgtgtacat ttggcatttg tgttattatt ttgcactgtt ttctgtcgtg     3660

tgtgttggga tgggatccca ggccagggaa agcccgtgtc aatgaatgcc ggggacagag     3720

aggggcaggt tgaccgggac ttcaaagccg tgatcgtgaa tatcgagaac tgccattgtc     3780

gtctttatgt ccgcccacct agtgcttcca cttctatgca aatgcctcca agccattcac     3840

ttccccaatc ttgtcgttga tgggtatgtg tttaaaacat gcacggtgag gccgggcgca     3900

gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcgggtggat catgaggtca     3960

ggagatcgag accatcctgg ctaacacgtg aaaccccgtc tctactaaaa atacaaaaaa     4020

ttagccgggc gtggtggcgg gcacctgtag tcccagctac tcgggaggct gaggcaggag     4080

aatggtgtga acccgggaag cggagcttgc agtgagccga gattgcgcca ctgcagtccg     4140

cagtctggcc tgggcgacag agcgagactc cgtctcaaaa aaaaaaaaca aaaaaaaacc     4200

atgcatggtg catcagcagc ccatggcctc tggccaggca tggcgaggct gaggtgggag     4260

gatggtttga gctcaggcat ttgaggctgt cgtgagctat gattatgcca ctgctttcca     4320

gcctgggcaa catagtaaga ccccatctct taaaaaatga atttggccag acacaggtgc     4380

ctcacgcctg taatcccagc actttgggag gctgagctgg atcacttgag ttcaggagtt     4440

ggagaccagg cctgagcaac aaagcgagat cccatctcta caaaaaccaa aaagttaaaa     4500

atcagctggg tacggtggca cgtgcctgtg atcccagcta cttgggaggc tgaggcagga     4560

ggatcgcctg agcccaggag gtggaggttg cagtgagcca tgatcgagcc actgcactcc     4620

agcctgggca acagatgaag accctatttc agaaatacaa ctataaaaaa ataaataaat     4680

cctccagtct ggatcgtttg acgggacttc aggttctttc tgaaatcgcc gtgttactgt     4740

tgcactgatg tccggagaga cagtgacagc ctccgtcaga ctcccgcgtg aagatgtcac     4800

aagggattgg caattgtccc cagggacaaa acactgtgtc ccccccagtg cagggaaccg     4860

tgataagcct ttctggtttc ggagcacgta aatgcgtccc tgtacagata gtggggattt     4920

tttgttatgt ttgcactttg tatattggtt gaaactgtta tcacttatat atatatatat     4980

acacacatat atataaaatc tatttatttt tgcaaaccct ggttgctgta tttgttcagt     5040

gactattctc ggggccctgt gtagggggtt attgcctctg aaatgcctct tctttatgta     5100

caaagattat ttgcacgaac tggactgtgt gcaacgcttt ttgggagaat gatgtccccg     5160

ttgtatgtat gagtggcttc tgggagatgg gtgtcacttt ttaaaccact gtatagaagg     5220

tttttgtagc ctgaatgtct tactgtgatc aattaaattt cttaaatgaa ccaatttgtc     5280

taaaaaaaaa aa                                                         5292


<210> 7
<211> 860
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210> 8
<211> 10515
<212> DNA
<213> Homo sapiens

<400> 8
ggaggaggga gagcacaggc tttgaccgat agtaacctct gcgctcggtg cagccgaatc       60

tataaaagga actagtcccg gcaaaaaccc cgtaattgcg agcgagagtg agtggggccg      120

ggacccgcag agccgagccg acccttctct cccgggctgc ggcagggcag ggcggggagc      180

tccgcgcacc aacagagccg gttctcaggg cgctttgctc cttgtttttt ccccggttct      240

gttttctccc cttctccgga aggcttgtca aggggtagga gaaagagacg caaacacaaa      300

agtggaaaac agttaatgac cagccacggc gtccctgctg tgagctctgg ccgctgcctt      360

ccagggctcc cgagccacac gctgggggtg ctggctgagg gaacatggct tgttggcctc      420

agctgaggtt gctgctgtgg aagaacctca ctttcagaag aagacaaaca tgtcagctgc      480

tgctggaagt ggcctggcct ctatttatct tcctgatcct gatctctgtt cggctgagct      540

acccacccta tgaacaacat gaatgccatt ttccaaataa agccatgccc tctgcaggaa      600

cacttccttg ggttcagggg attatctgta atgccaacaa cccctgtttc cgttacccga      660

ctcctgggga ggctcccgga gttgttggaa actttaacaa atccattgtg gctcgcctgt      720

tctcagatgc tcggaggctt cttttataca gccagaaaga caccagcatg aaggacatgc      780

gcaaagttct gagaacatta cagcagatca agaaatccag ctcaaacttg aagcttcaag      840

atttcctggt ggacaatgaa accttctctg ggttcctgta tcacaacctc tctctcccaa      900

agtctactgt ggacaagatg ctgagggctg atgtcattct ccacaaggta tttttgcaag      960

gctaccagtt acatttgaca agtctgtgca atggatcaaa atcagaagag atgattcaac     1020

ttggtgacca agaagtttct gagctttgtg gcctaccaag ggagaaactg gctgcagcag     1080

agcgagtact tcgttccaac atggacatcc tgaagccaat cctgagaaca ctaaactcta     1140

catctccctt cccgagcaag gagctggctg aagccacaaa aacattgctg catagtcttg     1200

ggactctggc ccaggagctg ttcagcatga gaagctggag tgacatgcga caggaggtga     1260

tgtttctgac caatgtgaac agctccagct cctccaccca aatctaccag gctgtgtctc     1320

gtattgtctg cgggcatccc gagggagggg ggctgaagat caagtctctc aactggtatg     1380

aggacaacaa ctacaaagcc ctctttggag gcaatggcac tgaggaagat gctgaaacct     1440

tctatgacaa ctctacaact ccttactgca atgatttgat gaagaatttg gagtctagtc     1500

ctctttcccg cattatctgg aaagctctga agccgctgct cgttgggaag atcctgtata     1560

cacctgacac tccagccaca aggcaggtca tggctgaggt gaacaagacc ttccaggaac     1620

tggctgtgtt ccatgatctg gaaggcatgt gggaggaact cagccccaag atctggacct     1680

tcatggagaa cagccaagaa atggaccttg tccggatgct gttggacagc agggacaatg     1740

accacttttg ggaacagcag ttggatggct tagattggac agcccaagac atcgtggcgt     1800

ttttggccaa gcacccagag gatgtccagt ccagtaatgg ttctgtgtac acctggagag     1860

aagctttcaa cgagactaac caggcaatcc ggaccatatc tcgcttcatg gagtgtgtca     1920

acctgaacaa gctagaaccc atagcaacag aagtctggct catcaacaag tccatggagc     1980

tgctggatga gaggaagttc tgggctggta ttgtgttcac tggaattact ccaggcagca     2040

ttgagctgcc ccatcatgtc aagtacaaga tccgaatgga cattgacaat gtggagagga     2100

caaataaaat caaggatggg tactgggacc ctggtcctcg agctgacccc tttgaggaca     2160

tgcggtacgt ctgggggggc ttcgcctact tgcaggatgt ggtggagcag gcaatcatca     2220

gggtgctgac gggcaccgag aagaaaactg gtgtctatat gcaacagatg ccctatccct     2280

gttacgttga tgacatcttt ctgcgggtga tgagccggtc aatgcccctc ttcatgacgc     2340

tggcctggat ttactcagtg gctgtgatca tcaagggcat cgtgtatgag aaggaggcac     2400

ggctgaaaga gaccatgcgg atcatgggcc tggacaacag catcctctgg tttagctggt     2460

tcattagtag cctcattcct cttcttgtga gcgctggcct gctagtggtc atcctgaagt     2520

taggaaacct gctgccctac agtgatccca gcgtggtgtt tgtcttcctg tccgtgtttg     2580

ctgtggtgac aatcctgcag tgcttcctga ttagcacact cttctccaga gccaacctgg     2640

cagcagcctg tgggggcatc atctacttca cgctgtacct gccctacgtc ctgtgtgtgg     2700

catggcagga ctacgtgggc ttcacactca agatcttcgc tagcctgctg tctcctgtgg     2760

cttttgggtt tggctgtgag tactttgccc tttttgagga gcagggcatt ggagtgcagt     2820

gggacaacct gtttgagagt cctgtggagg aagatggctt caatctcacc acttcggtct     2880

ccatgatgct gtttgacacc ttcctctatg gggtgatgac ctggtacatt gaggctgtct     2940

ttccaggcca gtacggaatt cccaggccct ggtattttcc ttgcaccaag tcctactggt     3000

ttggcgagga aagtgatgag aagagccacc ctggttccaa ccagaagaga atatcagaaa     3060

tctgcatgga ggaggaaccc acccacttga agctgggcgt gtccattcag aacctggtaa     3120

aagtctaccg agatgggatg aaggtggctg tcgatggcct ggcactgaat ttttatgagg     3180

gccagatcac ctccttcctg ggccacaatg gagcggggaa gacgaccacc atgtcaatcc     3240

tgaccgggtt gttccccccg acctcgggca ccgcctacat cctgggaaaa gacattcgct     3300

ctgagatgag caccatccgg cagaacctgg gggtctgtcc ccagcataac gtgctgtttg     3360

acatgctgac tgtcgaagaa cacatctggt tctatgcccg cttgaaaggg ctctctgaga     3420

agcacgtgaa ggcggagatg gagcagatgg ccctggatgt tggtttgcca tcaagcaagc     3480

tgaaaagcaa aacaagccag ctgtcaggtg gaatgcagag aaagctatct gtggccttgg     3540

cctttgtcgg gggatctaag gttgtcattc tggatgaacc cacagctggt gtggaccctt     3600

actcccgcag gggaatatgg gagctgctgc tgaaataccg acaaggccgc accattattc     3660

tctctacaca ccacatggat gaagcggacg tcctggggga caggattgcc atcatctccc     3720

atgggaagct gtgctgtgtg ggctcctccc tgtttctgaa gaaccagctg ggaacaggct     3780

actacctgac cttggtcaag aaagatgtgg aatcctccct cagttcctgc agaaacagta     3840

gtagcactgt gtcatacctg aaaaaggagg acagtgtttc tcagagcagt tctgatgctg     3900

gcctgggcag cgaccatgag agtgacacgc tgaccatcga tgtctctgct atctccaacc     3960

tcatcaggaa gcatgtgtct gaagcccggc tggtggaaga catagggcat gagctgacct     4020

atgtgctgcc atatgaagct gctaaggagg gagcctttgt ggaactcttt catgagattg     4080

atgaccggct ctcagacctg ggcatttcta gttatggcat ctcagagacg accctggaag     4140

aaatattcct caaggtggcc gaagagagtg gggtggatgc tgagacctca gatggtacct     4200

tgccagcaag acgaaacagg cgggccttcg gggacaagca gagctgtctt cgcccgttca     4260

ctgaagatga tgctgctgat ccaaatgatt ctgacataga cccagaatcc agagagacag     4320

acttgctcag tgggatggat ggcaaagggt cctaccaggt gaaaggctgg aaacttacac     4380

agcaacagtt tgtggccctt ttgtggaaga gactgctaat tgccagacgg agtcggaaag     4440

gattttttgc tcagattgtc ttgccagctg tgtttgtctg cattgccctt gtgttcagcc     4500

tgatcgtgcc accctttggc aagtacccca gcctggaact tcagccctgg atgtacaacg     4560

aacagtacac atttgtcagc aatgatgctc ctgaggacac gggaaccctg gaactcttaa     4620

acgccctcac caaagaccct ggcttcggga cccgctgtat ggaaggaaac ccaatcccag     4680

acacgccctg ccaggcaggg gaggaagagt ggaccactgc cccagttccc cagaccatca     4740

tggacctctt ccagaatggg aactggacaa tgcagaaccc ttcacctgca tgccagtgta     4800

gcagcgacaa aatcaagaag atgctgcctg tgtgtccccc aggggcaggg gggctgcctc     4860

ctccacaaag aaaacaaaac actgcagata tccttcagga cctgacagga agaaacattt     4920

cggattatct ggtgaagacg tatgtgcaga tcatagccaa aagcttaaag aacaagatct     4980

gggtgaatga gtttaggtat ggcggctttt ccctgggtgt cagtaatact caagcacttc     5040

ctccgagtca agaagttaat gatgccatca aacaaatgaa gaaacaccta aagctggcca     5100

aggacagttc tgcagatcga tttctcaaca gcttgggaag atttatgaca ggactggaca     5160

ccaaaaataa tgtcaaggtg tggttcaata acaagggctg gcatgcaatc agctctttcc     5220

tgaatgtcat caacaatgcc attctccggg ccaacctgca aaagggagag aaccctagcc     5280

attatggaat tactgctttc aatcatcccc tgaatctcac caagcagcag ctctcagagg     5340

tggctctgat gaccacatca gtggatgtcc ttgtgtccat ctgtgtcatc tttgcaatgt     5400

ccttcgtccc agccagcttt gtcgtattcc tgatccagga gcgggtcagc aaagcaaaac     5460

acctgcagtt catcagtgga gtgaagcctg tcatctactg gctctctaat tttgtctggg     5520

atatgtgcaa ttacgttgtc cctgccacac tggtcattat catcttcatc tgcttccagc     5580

agaagtccta tgtgtcctcc accaatctgc ctgtgctagc ccttctactt ttgctgtatg     5640

ggtggtcaat cacacctctc atgtacccag cctcctttgt gttcaagatc cccagcacag     5700

cctatgtggt gctcaccagc gtgaacctct tcattggcat taatggcagc gtggccacct     5760

ttgtgctgga gctgttcacc gacaataagc tgaataatat caatgatatc ctgaagtccg     5820

tgttcttgat cttcccacat ttttgcctgg gacgagggct catcgacatg gtgaaaaacc     5880

aggcaatggc tgatgccctg gaaaggtttg gggagaatcg ctttgtgtca ccattatctt     5940

gggacttggt gggacgaaac ctcttcgcca tggccgtgga aggggtggtg ttcttcctca     6000

ttactgttct gatccagtac agattcttca tcaggcccag acctgtaaat gcaaagctat     6060

ctcctctgaa tgatgaagat gaagatgtga ggcgggaaag acagagaatt cttgatggtg     6120

gaggccagaa tgacatctta gaaatcaagg agttgacgaa gatatataga aggaagcgga     6180

agcctgctgt tgacaggatt tgcgtgggca ttcctcctgg tgagtgcttt gggctcctgg     6240

gagttaatgg ggctggaaaa tcatcaactt tcaagatgtt aacaggagat accactgtta     6300

ccagaggaga tgctttcctt aacaaaaata gtatcttatc aaacatccat gaagtacatc     6360

agaacatggg ctactgccct cagtttgatg ccatcacaga gctgttgact gggagagaac     6420

acgtggagtt ctttgccctt ttgagaggag tcccagagaa agaagttggc aaggttggtg     6480

agtgggcgat tcggaaactg ggcctcgtga agtatggaga aaaatatgct ggtaactata     6540

gtggaggcaa caaacgcaag ctctctacag ccatggcttt gatcggcggg cctcctgtgg     6600

tgtttctgga tgaacccacc acaggcatgg atcccaaagc ccggcggttc ttgtggaatt     6660

gtgccctaag tgttgtcaag gaggggagat cagtagtgct tacatctcat agtatggaag     6720

aatgtgaagc tctttgcact aggatggcaa tcatggtcaa tggaaggttc aggtgccttg     6780

gcagtgtcca gcatctaaaa aataggtttg gagatggtta tacaatagtt gtacgaatag     6840

cagggtccaa cccggacctg aagcctgtcc aggatttctt tggacttgca tttcctggaa     6900

gtgttctaaa agagaaacac cggaacatgc tacaatacca gcttccatct tcattatctt     6960

ctctggccag gatattcagc atcctctccc agagcaaaaa gcgactccac atagaagact     7020

actctgtttc tcagacaaca cttgaccaag tatttgtgaa ctttgccaag gaccaaagtg     7080

atgatgacca cttaaaagac ctctcattac acaaaaacca gacagtagtg gacgttgcag     7140

ttctcacatc ttttctacag gatgagaaag tgaaagaaag ctatgtatga agaatcctgt     7200

tcatacgggg tggctgaaag taaagaggaa ctagactttc ctttgcacca tgtgaagtgt     7260

tgtggagaaa agagccagaa gttgatgtgg gaagaagtaa actggatact gtactgatac     7320

tattcaatgc aatgcaattc aatgcaatga aaacaaaatt ccattacagg ggcagtgcct     7380

ttgtagccta tgtcttgtat ggctctcaag tgaaagactt gaatttagtt ttttacctat     7440

acctatgtga aactctatta tggaacccaa tggacatatg ggtttgaact cacacttttt     7500

tttttttttt tgttcctgtg tattctcatt ggggttgcaa caataattca tcaagtaatc     7560

atggccagcg attattgatc aaaatcaaaa ggtaatgcac atcctcattc actaagccat     7620

gccatgccca ggagactggt ttcccggtga cacatccatt gctggcaatg agtgtgccag     7680

agttattagt gccaagtttt tcagaaagtt tgaagcacca tggtgtgtca tgctcacttt     7740

tgtgaaagct gctctgctca gagtctatca acattgaata tcagttgaca gaatggtgcc     7800

atgcgtggct aacatcctgc tttgattccc tctgataagc tgttctggtg gcagtaacat     7860

gcaacaaaaa tgtgggtgtc tccaggcacg ggaaacttgg ttccattgtt atattgtcct     7920

atgcttcgag ccatgggtct acagggtcat ccttatgaga ctcttaaata tacttagatc     7980

ctggtaagag gcaaagaatc aacagccaaa ctgctggggc tgcaagctgc tgaagccagg     8040

gcatgggatt aaagagattg tgcgttcaaa cctagggaag cctgtgccca tttgtcctga     8100

ctgtctgcta acatggtaca ctgcatctca agatgtttat ctgacacaag tgtattattt     8160

ctggcttttt gaattaatct agaaaatgaa aagatggagt tgtattttga caaaaatgtt     8220

tgtacttttt aatgttattt ggaattttaa gttctatcag tgacttctga atccttagaa     8280

tggcctcttt gtagaaccct gtggtataga ggagtatggc cactgcccca ctatttttat     8340

tttcttatgt aagtttgcat atcagtcatg actagtgcct agaaagcaat gtgatggtca     8400

ggatctcatg acattatatt tgagtttctt tcagatcatt taggatactc ttaatctcac     8460

ttcatcaatc aaatattttt tgagtgtatg ctgtagctga aagagtatgt acgtacgtat     8520

aagactagag agatattaag tctcagtaca cttcctgtgc catgttattc agctcactgg     8580

tttacaaata taggttgtct tgtggttgta ggagcccact gtaacaatac tgggcagcct     8640

tttttttttt ttttttaatt gcaacaatgc aaaagccaag aaagtataag ggtcacaagt     8700

ctaaacaatg aattcttcaa cagggaaaac agctagcttg aaaacttgct gaaaaacaca     8760

acttgtgttt atggcattta gtaccttcaa ataattggct ttgcagatat tggatacccc     8820

attaaatctg acagtctcaa atttttcatc tcttcaatca ctagtcaaga aaaatataaa     8880

aacaacaaat acttccatat ggagcatttt tcagagtttt ctaacccagt cttatttttc     8940

tagtcagtaa acatttgtaa aaatactgtt tcactaatac ttactgttaa ctgtcttgag     9000

agaaaagaaa aatatgagag aactattgtt tggggaagtt caagtgatct ttcaatatca     9060

ttactaactt cttccacttt ttccagaatt tgaatattaa cgctaaaggt gtaagacttc     9120

agatttcaaa ttaatctttc tatatttttt aaatttacag aatattatat aacccactgc     9180

tgaaaaagaa aaaaatgatt gttttagaag ttaaagtcaa tattgatttt aaatataagt     9240

aatgaaggca tatttccaat aactagtgat atggcatcgt tgcattttac agtatcttca     9300

aaaatacaga atttatagaa taatttctcc tcatttaata tttttcaaaa tcaaagttat     9360

ggtttcctca ttttactaaa atcgtattct aattcttcat tatagtaaat ctatgagcaa     9420

ctccttactt cggttcctct gatttcaagg ccatatttta aaaaatcaaa aggcactgtg     9480

aactattttg aagaaaacac aacattttaa tacagattga aaggacctct tctgaagcta     9540

gaaacaatct atagttatac atcttcatta atactgtgtt accttttaaa atagtaattt     9600

tttacatttt cctgtgtaaa cctaattgtg gtagaaattt ttaccaactc tatactcaat     9660

caagcaaaat ttctgtatat tccctgtgga atgtacctat gtgagtttca gaaattctca     9720

aaatacgtgt tcaaaaattt ctgcttttgc atctttggga cacctcagaa aacttattaa     9780

caactgtgaa tatgagaaat acagaagaaa ataataagcc ctctatacat aaatgcccag     9840

cacaattcat tgttaaaaaa caaccaaacc tcacactact gtatttcatt atctgtactg     9900

aaagcaaatg ctttgtgact attaaatgtt gcacatcatt cattcactgt atagtaatca     9960

ttgactaaag ccatttgtct gtgttttctt cttgtggttg tatatatcag gtaaaatatt    10020

ttccaaagag ccatgtgtca tgtaatactg aaccactttg atattgagac attaatttgt    10080

acccttgtta ttatctacta gtaataatgt aatactgtag aaatattgct ctaattcttt    10140

tcaaaattgt tgcatccccc ttagaatgtt tctatttcca taaggattta ggtatgctat    10200

tatcccttct tataccctaa gatgaagctg tttttgtgct ctttgttcat cattggccct    10260

cattccaagc actttacgct gtctgtaatg ggatctattt ttgcactgga atatctgaga    10320

attgcaaaac tagacaaaag tttcacaaca gatttctaag ttaaatcatt ttcattaaaa    10380

ggaaaaaaga aaaaaaattt tgtatgtcaa taactttata tgaagtatta aaatgcatat    10440

ttctatgttg taatataatg agtcacaaaa taaagctgtg acagttctgt tggtctacag    10500

aaaaaaaaaa aaaaa                                                     10515


<210> 9
<211> 2261
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210> 10
<211> 5130
<212> DNA
<213> Homo sapiens

<400> 10
agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac       60

gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc      120

ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc      180

aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac      240

ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct      300

gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag      360

aatggaagga aatctgatgt acctggagta gtaaaaacag gctccacgaa ggagctggat      420

gaaaaagaaa gtcggcgtct gttccaacag atcctttctg gtgtggatta ttgtcacagg      480

catatggtgg tccatagaga tttgaaacct gaaaatgtcc tgcttgatgc acacatgaat      540

gcaaagatag ctgattttgg tctttcaaac atgatgtcag atggtgaatt tttaagaaca      600

agttgtggct cacccaacta tgctgcacca gaagtaattt caggaagatt gtatgcaggc      660

ccagaggtag atatatggag cagtggggtt attctctatg ctttattatg tggaaccctt      720

ccatttgatg atgaccatgt gccaactctt tttaagaaga tatgtgatgg gatcttctat      780

acccctcaat atttaaatcc ttctgtgatt agccttttga aacatatgct gcaggtggat      840

cccatgaaga gggccacaat caaagatatc agggaacatg aatggtttaa acaggacctt      900

ccaaaatatc tctttcctga ggatccatca tatagttcaa ccatgattga tgatgaagcc      960

ttaaaagaag tatgtgaaaa gtttgagtgc tcagaagagg aagttctcag ctgtctttac     1020

aacagaaatc accaggatcc tttggcagtt gcctaccatc tcataataga taacaggaga     1080

ataatgaatg aagccaaaga tttctatttg gcgacaagcc cacctgattc ttttcttgat     1140

gatcatcacc tgactcggcc ccatcctgaa agagtaccat tcttggttgc tgaaacacca     1200

agggcacgcc atacccttga tgaattaaat ccacagaaat ccaaacacca aggtgtaagg     1260

aaagcaaaat ggcatttagg aattagaagt caaagtcgac caaatgatat tatggcagaa     1320

gtatgtagag caatcaaaca attggattat gaatggaagg ttgtaaaccc atattatttg     1380

cgtgtacgaa ggaagaatcc tgtgacaagc acttactcca aaatgagtct acagttatac     1440

caagtggata gtagaactta tctactggat ttccgtagta ttgatgatga aattacagaa     1500

gccaaatcag ggactgctac tccacagaga tcgggatcag ttagcaacta tcgatcttgc     1560

caaaggagtg attcagatgc tgaggctcaa ggaaaatcct cagaagtttc tcttacctca     1620

tctgtgacct cacttgactc ttctcctgtt gacctaactc caagacctgg aagtcacaca     1680

atagaatttt ttgagatgtg tgcaaatcta attaaaattc ttgcacaata aacagaaaac     1740

tttgcttatt tcttttgcag caataagcat gcataataag tcacagccaa atgcttccat     1800

ttgtaatcaa gttatacata attataaccg agggctggcg ttttggaatg caatttgcac     1860

agggattgga acatgattta tagttaaaag cctaatatgc agaaatgaat taagatcatt     1920

ttgttgttca ttgtgcagta tgtatatagc ataatataca cagtgaatta taggtctcag     1980

gcttacttga tttttggcta ttttatattt agtgtacaca gggctttgaa atattaattt     2040

acataaaggc cttcatatat tattacgtgt tatatattac gtgttataaa tttattcaat     2100

aaatatttgc ctagaattcc caagaccttt ataggtgatt ttgttttctg ggctccttaa     2160

cttcataaat agctagtatc ttccagcagt agtaacagtc tggataactt cttccatatc     2220

cctccctctt tgtttttttg agacagtgtc actttgtcac ccaggctgga gtgcaatggt     2280

gtggtctcgg ctcactgcaa cctccacctc ccgggttcaa gtgattctcc cgcctcagct     2340

tcctgagtag ctggaactac aggcgtgtgc caccacaccc ggctaatttt tcgtattttt     2400

agtgtagacg gggtttcact atgttgccca ggctggtctc gaactcctga ccgcgtgatc     2460

caccacctca gcttcccaaa gtggtgggat tacaggcgtg agccaccgca cccggcctcc     2520

atatccccct tttaaaattc tgtagtgtat ggtaagtcat atcagatatc agacctaatt     2580

taaatttcat tttagcttta caagtccaaa aacacagaat ttatatattc agatactcta     2640

gcactaattt tagtcttaaa atattcccac gatattctgt acacaaaatg ttctttttgt     2700

tacaagagct gagttgcata tactgtagat aaatcatatt atttttgcca atttcacaaa     2760

ttcctctggc ccatcatgtc agtcattatt gagtatatgc acacattgct acttatttga     2820

ttatgtatct tttaaattga ttcagtgcat agaaaactat ctcttacaaa ctttaagtgc     2880

tctgatatga cttccccccc aaattttatt atgaacattt ttaaaaacag aaaaattgaa     2940

aaactgtttg gtaagcacat gtatatctac catttagatt cagcagttgt taatgttttg     3000

tcatttgttt tctctatacc tatatatgta tagatacagc tagttatgca tatatatgca     3060

tatatgtgtt tgtttgtgta tgtatatatg cttttttccc cctgaaccat ttggatgtta     3120

cagacatact tatcaccgtg aaaatacttc aagtatctcc tacagataat gacattctcc     3180

taaaaatccg taataccatt gtaaaagtaa taattcccca atatcatcta atcaagccat     3240

atttaaattt ctgaagttaa ctccaaattt ctttatagct gattatttca aactaggatc     3300

caattaaagt ttacatatga cacttggtta taactcttta gttggatata acattattat     3360

tattttgata aaatatggaa caaatcaatt ctattaataa gtggtcacat ttgttttggg     3420

cttaaattac tttttaaaga tactggattt tcctaagatt tctgatttac actgatattt     3480

ttttttgtca ttcttaattg catcacacaa tagatgtaaa tgaagatgta gtcacctcag     3540

ataaaattgg tatcgtgtat gataatattg tatcatttat atttgcctta tgttaacttt     3600

aagaaattga tttttttgta ttaatcattt tcccattgca acagagctat attttttcta     3660

ttttaagaat catattttag gattattttt ggcaaataca gtgagcactt atgtaaccag     3720

atgataatga actcaaatgt catgatagct tgcataaatg gtgactctag tagatttgac     3780

tcaagcactt ctagaatcat gcactgaatt caaaagaaaa atcttgctgc tttttgtcca     3840

gggcttgttc tattcaactt ctaatttgaa agctgtacaa agtaatagaa gttccattta     3900

aatatgagtt caaaactgta tttacttttt atgtggccct ctctttaggg gattctaatt     3960

ttacttaggg tctctaagtg cagcataatg ttcctgatgt taacagaaga ctgtattttt     4020

aaagttacaa atttgtatat ggaattaagt aatggcgcta tatacgctgt tgtggggagg     4080

ggggaagaaa aggaggaacc aattaaatag gaccttttaa aaattgttaa ttttgtaaac     4140

tttgcttctc ttataagtta ttgtgattca ttttagttac tgtgttttat tttgaaaata     4200

tttaaatatt gcacttctat aaatagtatg ataaatgcac agacaattgc agtaaattct     4260

tttttaagct aggatatttg aaatgacaac ctttggttaa gtgtgtcaag gttgcaacag     4320

aattttcaca atttttttgt tgtttgcaaa ttgttactaa tattgaagag gtaagggagg     4380

caatgcaaat gatttttaat ctttttttat tatcttttca gcagtttata ttttttgtga     4440

ctttatgcaa ccatattttt actttgtctt gacaactgaa agatgtataa ggttttttgc     4500

cagaaatgta ctgtatacat agttttaagt ataacagatt ttactgatat gtaaaaattt     4560

tgccattaaa ataaatgatt tctcactgag aggaactttt ctaccaggtt ggggcatatg     4620

ggagcttaat atatcatatc taatttaaaa taatttcact gaaataaact ccattgcttt     4680

tacctaattt ttttcttgag atgcttttgt agtttttcag agttttagat gattttatac     4740

aaaatcctct gcctagcact gctctttttg atgttgtagt gacaccattt acattgaatt     4800

aatgcttggt agcctggggc tagatgtgga actccatgga tctgtgttct gactggcacc     4860

tttggaatga aagaaaagtg tgtgctgtcc aaattttttc cccttaattc tttccctcat     4920

cttctcaccc ataatagaaa ttttatttcc attgtgagtt ctgacaagaa tgaaattcca     4980

catacaacat aactgtaaat tgttggtagg tagaagttaa tatttgtggt tcatgtatat     5040

tttgaccaga gtatatttaa gtatataatt tcagcttcct tgatttagaa atatgatata     5100

ataaagaaaa actccattta tcatctgtta                                      5130


<210> 11
<211> 574
<212> PRT
<213> Homo sapiens

<400> 11
Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Lys Ser Asp Val Pro Gly Val 
        115                 120                 125             


Val Lys Thr Gly Ser Thr Lys Glu Leu Asp Glu Lys Glu Ser Arg Arg 
    130                 135                 140                 


Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His Met 
145                 150                 155                 160 


Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala His 
                165                 170                 175     


Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp 
            180                 185                 190         


Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro 
        195                 200                 205             


Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp 
    210                 215                 220                 


Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe 
225                 230                 235                 240 


Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly Ile 
                245                 250                 255     


Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu Lys 
            260                 265                 270         


His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp Ile 
        275                 280                 285             


Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe Pro 
    290                 295                 300                 


Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu Lys 
305                 310                 315                 320 


Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser Cys 
                325                 330                 335     


Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His Leu 
            340                 345                 350         


Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr Leu 
        355                 360                 365             


Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr Arg 
    370                 375                 380                 


Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg Ala 
385                 390                 395                 400 


Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln Gly 
                405                 410                 415     


Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg Pro 
            420                 425                 430         


Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp Tyr 
        435                 440                 445             


Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys Asn 
    450                 455                 460                 


Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln Val 
465                 470                 475                 480 


Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu Ile 
                485                 490                 495     


Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser Val 
            500                 505                 510         


Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala Gln 
        515                 520                 525             


Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu Asp 
    530                 535                 540                 


Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile Glu 
545                 550                 555                 560 


Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
                565                 570                 


<210> 12
<211> 5260
<212> DNA
<213> Homo sapiens

<400> 12
ggacccgcct cagccaatcc gctgctgccg gcgtcgggtg cgctcggcct cgcccgcggc       60

cctccttccc cggctcccgc tcgccgctcg ttcactccac cgccgccgcc gccgccgccg      120

ctgccgctgc cgctgccgca cctccgtagc tgactcggta ctctctgaag atggcagaag      180

ctcaccaagc tgtggccttt cagttcacgg tcactccgga cgggattgac ctgcggctga      240

gccatgaagc tcttagacaa atctatctct ctggacttca ttcctggaaa aagaagttca      300

tcagattcaa gaacggcatc atcactggcg tgtacccggc aagcccctcc agttggctta      360

tcgtggtggt gggcgtgatg acaacgatgt acgccaagat cgacccctcg ttaggaataa      420

ttgcaaaaat caatcggact ctggaaacgg ccaactgcat gtccagccag acgaagaacg      480

tggtcagcgg cgtgctgttt ggcaccggcc tgtgggtggc cctcatcgtc accatgcgct      540

actccctgaa agtgctgctc tcctaccacg ggtggatgtt cactgagcac ggcaagatga      600

gtcgtgccac caagatctgg atgggtatgg tcaagatctt ttcaggccga aaacccatgt      660

tgtacagctt ccagacatcg ctgcctcgcc tgccggtccc ggctgtcaaa gacactgtga      720

acaggtatct acagtcggtg aggcctctta tgaaggaaga agacttcaaa cggatgacag      780

cacttgctca agattttgct gtcggtcttg gaccaagatt acagtggtat ttgaagttaa      840

aatcctggtg ggctacaaat tacgtgagcg actggtggga ggagtacatc tacctccgag      900

gacgagggcc gctcatggtg aacagcaact attatgccat ggatctgctg tatatccttc      960

caactcacat tcaggcagca agagccggca acgccatcca tgccatcctg ctttacaggc     1020

gcaaactgga ccgggaggaa atcaaaccaa ttcgtctttt gggatccacg attccactct     1080

gctccgctca gtgggagcgg atgtttaata cttcccggat cccaggagag gagacagaca     1140

ccatccagca catgagagac agcaagcaca tcgtcgtgta ccatcgagga cgctacttca     1200

aggtctggct ctaccatgat gggcggctgc tgaagccccg ggagatggag cagcagatgc     1260

agaggatcct ggacaatacc tcggagcctc agcccgggga ggccaggctg gcagccctca     1320

ccgcaggaga cagagttccc tgggccaggt gtcgtcaggc ctattttgga cgtgggaaaa     1380

ataagcagtc tcttgatgct gtggagaaag cagcgttctt cgtgacgtta gatgaaactg     1440

aagaaggata cagaagtgaa gacccggata cgtcaatgga cagctacgcc aaatctctac     1500

tacacggccg atgttacgac aggtggtttg acaagtcgtt cacgtttgtt gtcttcaaaa     1560

acgggaagat gggcctcaac gctgaacact cctgggcaga tgcgccgatc gtggcccacc     1620

tttgggagta cgtcatgtcc attgacagcc tccagctggg ctatgcggag gatgggcact     1680

gcaaaggcga catcaatccg aacattccgt accccaccag gctgcagtgg gacatcccgg     1740

gggaatgtca agaggttata gagacctccc tgaacaccgc aaatcttctg gcaaacgacg     1800

tggatttcca ttccttccca ttcgtagcct ttggtaaagg aatcatcaag aaatgtcgca     1860

cgagcccaga cgcctttgtg cagctggccc tccagctggc gcactacaag gacatgggca     1920

agttttgcct cacatacgag gcctccatga cccggctctt ccgagagggg aggacggaga     1980

ccgtgcgctc ctgcaccact gagtcatgcg acttcgtgcg ggccatggtg gacccggccc     2040

agacggtgga acagaggctg aagttgttca agttggcgtc tgagaagcat cagcatatgt     2100

atcgcctcgc catgaccggc tctgggatcg atcgtcacct cttctgcctt tacgtggtgt     2160

ctaaatatct cgctgtggag tcccctttcc ttaaggaagt tttatctgag ccttggagat     2220

tatcaacaag ccagacccct cagcagcaag tggagctgtt tgacttggag aataacccag     2280

agtacgtgtc cagcggaggg ggctttggac cggttgctga tgacggctat ggtgtgtcgt     2340

acatccttgt gggagagaac ctcatcaatt tccacatttc ttccaagttc tcttgccctg     2400

agacggattc tcatcgcttt ggaaggcacc tgaaagaagc aatgactgac atcatcactt     2460

tgtttggtct cagttctaat tccaaaaagt aattccactg gagctgctgg gaaggaaaac     2520

gagctcttct gatgcaaacc aaatgaaaaa taggcattaa tcctgacctt agctcgggat     2580

gaaacactgc tcttaaaaaa actcagtttt ccttccagaa aatgtgggtg tttttttttc     2640

ctagaacagt atctctcccc tgtgaagcat aaccccacta cttccagact tgccctccct     2700

tgggggacat ctgataaagt ctcccctgat gtctccgcat cggcttggat ttattaaggg     2760

atgcaaatct tgttgagtta atgaaggaat tagtagggtt gtggcttcac acacagtgga     2820

atggaaatgg tgtgctttct cagtggcaac cgaaggccta gtgcttaagg gcatttagca     2880

tcatccaagc agggtaaact tttgttttgt taaaagaaaa atgtgttatt caagttggtg     2940

tccccagttg tagctaacac atctggaatg cactaaccaa aatgctgtgc tttggagacc     3000

tgcttttgtc accgtgggta accgttcccg tctggtccag tagcctgtgt ttgcctctcc     3060

acatttgaag caagcaggat gcaaggtctt cagttttact gaccttgtat gtcttcaagt     3120

cttcacaacc cagtgcctta aaaatgaaag gccctaaatg taagggagat ggagagaaag     3180

atttattttg tagagtcttt gggtggaatt gtgggtatac tgttcccttc acaattgact     3240

gagtatggat aaccgtacat aagcatttgc tacaccccac cagccccctc cccctcagaa     3300

acaccagttc cttcccaagg gcagctgtgc cagactcccc tcccgggact gccttcttgt     3360

catcataagc aacaaaagaa ataacaggca catgtcataa aaggggagca agggccgtga     3420

tggtcagata attcactcaa gaataaaaca tgacacgtgc ctcaggagga tctctttccc     3480

aaagtgacag caaggagggc agggcatcgg ccaccaagcg gggactagca agtgaggaag     3540

gggagggcag cccaccgtgg tgaggagaga gtggctccac gaccccaagg gatggccttc     3600

tcctcccacc cggtgagggg aaagactcac cagagggtga tggagacagt atgccggctc     3660

accttggtga ccagccaaga tgtctcaagt gacagtgcta ggtgttcacc cagcctgtcc     3720

ttcagatagg agtgccttca cgaaagcgtc tcatggacca caaagcaatt atgcactgag     3780

tcatcttcag tatttaatgc aaaaatgaag catcatggaa tgaaattccc actgtctgtc     3840

atgacaagct tagctgtcca ttgttttaaa ttgtgtattt atttttttga ccacttggtt     3900

ctagttgggc ctgactcctt cagagtgctg caccccgata gtacaacagc gatggctgaa     3960

ctgttggagt cgatggaagg tgcttgccgg agaacacgtg cctttttttt tttttttttt     4020

tttgagatgg agtttcactc ttgttgccca ggctggagtg cagtggtgca atctcggctc     4080

actgcagcat ctgccttgca ggttcaagcg attctcctgt ctcagcctcc caagtagctg     4140

ggattacacg cccaacacca tgccctgcta atttttgtat ttttagtaga gacggggttt     4200

catcatattg gtcaggctgg tctcgaactc ctgacctcag gtgatccacc tgcctcagcc     4260

tcccaaagtg ctgggattac aggcatgagc caccatgcgc ggcccacatg catgttttat     4320

gtatgtatac ttcatgatgt aaaaatccca cctttatggg ccaaagattt tttttctcct     4380

gaaagcaaga aaaaatgaaa acaaaagaca aaaaaaaaaa aaaaagcgtc caggcgcggt     4440

ggctcatgcg tgtaatccca gcactttggg aggccaaggc gggcggatca cgaggtcagg     4500

agatggagac catcctggct aacacggtga aaccccgtct ctactaaaaa ttcaaaaaat     4560

gagccgggcg tggtggcggg cgcctgtagt cccagctact caggaggctg aggcaggaga     4620

atggcgtgaa cccgggaggc ggagcttgca gtgagccgag atcgctccac tgcactccag     4680

cctgggcgac agagcgagac tccgtctaaa aaaaaaagca aaaacaaacc aacaacaaaa     4740

gcccctgact gtccgtcaag caggcagcgg ggatgtagct ctctctgccc tgggcaagaa     4800

tagcacttcc cgttaaaagc cagcagccgg cgtcagtccc tatcagagcc agctagatca     4860

tgcactgttg accactgagc aatctgtgtt acactagagt tcacagggca ttttgagtgt     4920

agacgtgagt gcttaaacat atttgggttt ctctctcagg ttttaaatgt ttcaaatgta     4980

attgttgctc atcagtgcag ttatcaatgc aattttatat tccttgaggg gagaaagagg     5040

ggtcttattg tacatgtcca aggggggtga taagagtatt atctgtttaa tttaattgga     5100

acaaaccatt gtcttaacgc agccatggtt tgaatttgtt atcttgggct gaccggtgca     5160

tgtaaataca gtatgctctt tggatgtaaa tcttagaaat gcagtgtgaa tgtaggttat     5220

cattaataaa acattaaccc cagtctacta caaaaaaaaa                           5260


<210> 13
<211> 773
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
        35                  40                  45              


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
    50                  55                  60                  


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                85                  90                  95      


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
            100                 105                 110         


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
    130                 135                 140                 


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
145                 150                 155                 160 


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                165                 170                 175     


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
            180                 185                 190         


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
        195                 200                 205             


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                245                 250                 255     


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
        275                 280                 285             


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
    290                 295                 300                 


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
305                 310                 315                 320 


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                325                 330                 335     


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
            340                 345                 350         


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
        355                 360                 365             


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
    370                 375                 380                 


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
385                 390                 395                 400 


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                405                 410                 415     


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
            420                 425                 430         


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
        435                 440                 445             


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
465                 470                 475                 480 


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                485                 490                 495     


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
            500                 505                 510         


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
        515                 520                 525             


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
    530                 535                 540                 


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
545                 550                 555                 560 


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
                565                 570                 575     


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
            580                 585                 590         


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
        595                 600                 605             


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
    610                 615                 620                 


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
625                 630                 635                 640 


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                645                 650                 655     


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
            660                 665                 670         


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
        675                 680                 685             


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
    690                 695                 700                 


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
705                 710                 715                 720 


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                725                 730                 735     


Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg 
            740                 745                 750         


His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser 
        755                 760                 765             


Ser Asn Ser Lys Lys 
    770             


<210> 14
<211> 4706
<212> DNA
<213> Homo sapiens

<400> 14
cgcggccccg gaggcagcag cagcggcggc ggcagccgga gcagtaggca cccgagcagc       60

gccagcggcc gagcgggcgg cttcctggcc tgggcgctcc ggtggcggcg gaggtgcgcg      120

cggagccatg gttatcatgt cggagttcag cgcggacccc gcgggccagg gtcagggcca      180

gcagaagccc ctccgggtgg gtttttacga catcgagcgg accctgggca aaggcaactt      240

cgcggtggtg aagctggcgc ggcatcgagt caccaaaacg caggttgcaa taaaaataat      300

tgataaaaca cgattagatt caagcaattt ggagaaaatc tatcgtgagg ttcagctgat      360

gaagcttctg aaccatccac acatcataaa gctttaccag gttatggaaa caaaggacat      420

gctttacatc gtcactgaat ttgctaaaaa tggagaaatg tttgattatt tgacttccaa      480

cgggcacctg agtgagaacg aggcgcggaa gaagttctgg caaatcctgt cggccgtgga      540

gtactgtcac gaccatcaca tcgtccaccg ggacctcaag accgagaacc tcctgctgga      600

tggcaacatg gacatcaagc tggcagattt tggatttggg aatttctaca agtcaggaga      660

gcctctgtcc acgtggtgtg ggagcccccc gtatgccgcc ccggaagtct ttgaggggaa      720

ggagtatgaa ggcccccagc tggacatctg gagcctgggc gtggtgctgt acgtcctggt      780

ctgcggttct ctccccttcg atgggcctaa cctgccgacg ctgagacagc gggtgctgga      840

gggccgcttc cgcatcccct tcttcatgtc tcaagactgt gagagcctga tccgccgcat      900

gctggtggtg gaccccgcca ggcgcatcac catcgcccag atccggcagc accggtggat      960

gcgggctgag ccctgcttgc cgggacccgc ctgccccgcc ttctccgcac acagctacac     1020

ctccaacctg ggcgactacg atgagcaggc gctgggtatc atgcagaccc tgggcgtgga     1080

ccggcagagg acggtggagt cactgcaaaa cagcagctat aaccactttg ctgccattta     1140

ttacctcctc cttgagcggc tcaaggagta tcggaatgcc cagtgcgccc gccccgggcc     1200

tgccaggcag ccgcggcctc ggagctcgga cctcagtggt ttggaggtgc ctcaggaagg     1260

tctttccacc gaccctttcc gacctgcctt gctgtgcccg cagccgcaga ccttggtgca     1320

gtccgtcctc caggccgaga tggactgtga gctccagagc tcgctgcagt ggcccttgtt     1380

cttcccggtg gatgccagct gcagcggagt gttccggccc cggcccgtgt ccccaagcag     1440

cctgctggac acagccatca gtgaggaggc caggcagggg ccgggcctag aggaggagca     1500

ggacacgcag gagtccctgc ccagcagcac gggccggagg cacaccctgg ccgaggtctc     1560

cacccgcctc tccccactca ccgcgccatg tatagtcgtc tccccctcca ccacggcaag     1620

tcctgcagag ggaaccagct ctgacagttg tctgaccttc tctgcgagca aaagccccgc     1680

ggggctcagt ggcaccccgg ccactcaggg gctgctgggc gcctgctccc cggtcaggct     1740

ggcctcgccc ttcctggggt cgcagtccgc caccccagtg ctgcaggctc aggggggctt     1800

gggaggagct gttctgctcc ctgtcagctt ccaggaggga cggcgggcgt cggacacctc     1860

actgactcaa gggctgaagg cctttcggca gcagctgagg aagaccacgc ggaccaaagg     1920

gtttctggga ctgaacaaaa tcaaggggct ggctcgccag gtgtgccagg cccccgccag     1980

ccgggccagc aggggcggcc tgagcccctt ccacgcccct gcacagagcc caggcctgca     2040

cggcggcgca gccggcagcc gggagggctg gagcctgctg gaggaggtgc tagagcagca     2100

gaggctgctc cagttacagc accacccggc cgctgcaccc ggctgctccc aggcccccca     2160

gccggcccct gccccgtttg tgatcgcccc ctgtgatggc cctggggctg ccccgctccc     2220

cagcaccctc ctcacgtcgg ggctcccgct gctgccgccc ccactcctgc agaccggcgc     2280

gtccccggtg gcctcagcgg cgcagctcct ggacacacac ctgcacattg gcaccggccc     2340

caccgccctc cccgctgtgc ccccaccacg cctggccagg ctggccccag gttgtgagcc     2400

cctggggctg ctgcaggggg actgtgagat ggaggacctg atgccctgct ccctaggcac     2460

gtttgtcctg gtgcagtgag ggcagccctg catcctggca cggacactga ctcttacagc     2520

aataacttca gaggaggtga agacatctgg cctcaaagcc aagaactttc tagaagcgaa     2580

ataagcaata cgttaggtgt tttggctttt tagtttattt ttgttttatt tttttcttgc     2640

actgagtgac ctcaactttg agtagggact ggaaacttta ggaagaaaga taattgaggg     2700

gcgtgtctgg gggcgggggc aggaggggag cggggtggag ggaacacgtg cagtgccgtg     2760

gtgtggggat ctcggcccct ctctctgggt tcgtcgtggt tgagatgatt acctcggacg     2820

tctacggaaa cgagcgggcg cattgttgtc cgcttgtgtg tgtgtgtgtg tgtgtgtgtg     2880

tgcgcgtgca ttgattacta tccatttctt tagtcaacgc tctccacttc ctgatttctg     2940

ctttaaggaa aactgtgaac tttctgcttc atgtatcagt tttaaagcag cccaggcaaa     3000

gatcatctac agattctagg aattctctcc cctgaaatca aaacctggaa gacttttttt     3060

tcttatttta gttgagaagt ttcataaact gctcaaggat tagttttcca ggactctgcg     3120

gaggaacggc aggaagaacc tcagagaggg cagaggtgac ttcaaagtgc tggggactcc     3180

gtcctgaggg tcacttggcc ctgagcccct gcgtgccctt gcggaagccc agaagcttct     3240

tcctgctgca cctcccgttt ccgctgctgc tgacgtttat gcatttcatg atggggtcca     3300

acaagaacac ctgacttggg tgaagttgtg caatattgga ggctgactgt agggctgggc     3360

agctgggaga caggctcatg gctcatggct catggctcag ggcggtgcct gccctgggcc     3420

gggacccccc tccccacccc ccacctaggc tttttgggtt ttgttcaagg aaggtaaagt     3480

gagaggttta ggtcagtgtt tttaagtttt tgtttttttt ttaaagcaaa tcctgtatat     3540

gtatctacat gggagacagg tagacactac ttatttgtta cattttgtac tatacgtttg     3600

tgttccaggt ttcagcttcc ctcgctcctg ttgttaagaa gcgtccctgt cagcacaggt     3660

gtgcattgag gaaggggccc cagggccttc gctccctcag cactggggtg gaggcggcag     3720

gaaggggcgg cccttacctg gcaggtctgg gcgcaccttt agcaggtgga ctccgtgggg     3780

ctccaccagc cagaagcctc tggaaggcaa cgaaggcaat gctgctccct gagtccagtc     3840

cccgccccca aacccagccc aggtgccttc agctacttcg gcttcttaaa ccctgcagtg     3900

ttaaacagag gcattgagaa aggggaaagg cgggtatttt taaaagccaa agattgaccc     3960

agttacttga gggtagggag gcgggcccag tgcaggaggc tgcatccctg gcctgctggt     4020

gcccaccggg ggctgtgcct gtgccgggcc gcagggaagc tggctgcccc cattcctgct     4080

gctgctgctg ctgctgctct gtggctgttt caaagactgg gcgaaaggct gtccggaggg     4140

cagaccaggt gccttgccgc agagaaaaca ccaaagtctc ctgttcgctc ataaagaagt     4200

ttttgggatg ggagagaatc cagaccatct tggggcagcc aggcccttgc cttcattttt     4260

acagaggtag cacaactgat tccaacacaa aaccccttcc cctttttaaa atgatttctg     4320

ttctaatgcc atagatcaaa ggcctcagaa accattgtgt gtttcctctt tgaagcaatg     4380

acaagcactt tactttcacg gtggtttttg ttttttctta ttgctgtgga acctcttttg     4440

gaggacgtta aaggcgtgtt ttacttgttt ttttaagagt gtgtgatgtg tgttttgtag     4500

atttcttgac agtgctgtaa tacagacggc aatgcaatag cctatttaaa gacactacgt     4560

gatctgattg agatgtacat agtttttttt tttaccataa ctgaattatt ttatctctta     4620

tgttaacatg agaaatgtat gccaaatgat tagttgatgt atgtttttta atttaatatt     4680

taaataaaat atttggaagg aaaaaa                                          4706


<210> 15
<211> 783
<212> PRT
<213> Homo sapiens

<400> 15
Met Val Ile Met Ser Glu Phe Ser Ala Asp Pro Ala Gly Gln Gly Gln 
1               5                   10                  15      


Gly Gln Gln Lys Pro Leu Arg Val Gly Phe Tyr Asp Ile Glu Arg Thr 
            20                  25                  30          


Leu Gly Lys Gly Asn Phe Ala Val Val Lys Leu Ala Arg His Arg Val 
        35                  40                  45              


Thr Lys Thr Gln Val Ala Ile Lys Ile Ile Asp Lys Thr Arg Leu Asp 
    50                  55                  60                  


Ser Ser Asn Leu Glu Lys Ile Tyr Arg Glu Val Gln Leu Met Lys Leu 
65                  70                  75                  80  


Leu Asn His Pro His Ile Ile Lys Leu Tyr Gln Val Met Glu Thr Lys 
                85                  90                  95      


Asp Met Leu Tyr Ile Val Thr Glu Phe Ala Lys Asn Gly Glu Met Phe 
            100                 105                 110         


Asp Tyr Leu Thr Ser Asn Gly His Leu Ser Glu Asn Glu Ala Arg Lys 
        115                 120                 125             


Lys Phe Trp Gln Ile Leu Ser Ala Val Glu Tyr Cys His Asp His His 
    130                 135                 140                 


Ile Val His Arg Asp Leu Lys Thr Glu Asn Leu Leu Leu Asp Gly Asn 
145                 150                 155                 160 


Met Asp Ile Lys Leu Ala Asp Phe Gly Phe Gly Asn Phe Tyr Lys Ser 
                165                 170                 175     


Gly Glu Pro Leu Ser Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro 
            180                 185                 190         


Glu Val Phe Glu Gly Lys Glu Tyr Glu Gly Pro Gln Leu Asp Ile Trp 
        195                 200                 205             


Ser Leu Gly Val Val Leu Tyr Val Leu Val Cys Gly Ser Leu Pro Phe 
    210                 215                 220                 


Asp Gly Pro Asn Leu Pro Thr Leu Arg Gln Arg Val Leu Glu Gly Arg 
225                 230                 235                 240 


Phe Arg Ile Pro Phe Phe Met Ser Gln Asp Cys Glu Ser Leu Ile Arg 
                245                 250                 255     


Arg Met Leu Val Val Asp Pro Ala Arg Arg Ile Thr Ile Ala Gln Ile 
            260                 265                 270         


Arg Gln His Arg Trp Met Arg Ala Glu Pro Cys Leu Pro Gly Pro Ala 
        275                 280                 285             


Cys Pro Ala Phe Ser Ala His Ser Tyr Thr Ser Asn Leu Gly Asp Tyr 
    290                 295                 300                 


Asp Glu Gln Ala Leu Gly Ile Met Gln Thr Leu Gly Val Asp Arg Gln 
305                 310                 315                 320 


Arg Thr Val Glu Ser Leu Gln Asn Ser Ser Tyr Asn His Phe Ala Ala 
                325                 330                 335     


Ile Tyr Tyr Leu Leu Leu Glu Arg Leu Lys Glu Tyr Arg Asn Ala Gln 
            340                 345                 350         


Cys Ala Arg Pro Gly Pro Ala Arg Gln Pro Arg Pro Arg Ser Ser Asp 
        355                 360                 365             


Leu Ser Gly Leu Glu Val Pro Gln Glu Gly Leu Ser Thr Asp Pro Phe 
    370                 375                 380                 


Arg Pro Ala Leu Leu Cys Pro Gln Pro Gln Thr Leu Val Gln Ser Val 
385                 390                 395                 400 


Leu Gln Ala Glu Met Asp Cys Glu Leu Gln Ser Ser Leu Gln Trp Pro 
                405                 410                 415     


Leu Phe Phe Pro Val Asp Ala Ser Cys Ser Gly Val Phe Arg Pro Arg 
            420                 425                 430         


Pro Val Ser Pro Ser Ser Leu Leu Asp Thr Ala Ile Ser Glu Glu Ala 
        435                 440                 445             


Arg Gln Gly Pro Gly Leu Glu Glu Glu Gln Asp Thr Gln Glu Ser Leu 
    450                 455                 460                 


Pro Ser Ser Thr Gly Arg Arg His Thr Leu Ala Glu Val Ser Thr Arg 
465                 470                 475                 480 


Leu Ser Pro Leu Thr Ala Pro Cys Ile Val Val Ser Pro Ser Thr Thr 
                485                 490                 495     


Ala Ser Pro Ala Glu Gly Thr Ser Ser Asp Ser Cys Leu Thr Phe Ser 
            500                 505                 510         


Ala Ser Lys Ser Pro Ala Gly Leu Ser Gly Thr Pro Ala Thr Gln Gly 
        515                 520                 525             


Leu Leu Gly Ala Cys Ser Pro Val Arg Leu Ala Ser Pro Phe Leu Gly 
    530                 535                 540                 


Ser Gln Ser Ala Thr Pro Val Leu Gln Ala Gln Gly Gly Leu Gly Gly 
545                 550                 555                 560 


Ala Val Leu Leu Pro Val Ser Phe Gln Glu Gly Arg Arg Ala Ser Asp 
                565                 570                 575     


Thr Ser Leu Thr Gln Gly Leu Lys Ala Phe Arg Gln Gln Leu Arg Lys 
            580                 585                 590         


Thr Thr Arg Thr Lys Gly Phe Leu Gly Leu Asn Lys Ile Lys Gly Leu 
        595                 600                 605             


Ala Arg Gln Val Cys Gln Ala Pro Ala Ser Arg Ala Ser Arg Gly Gly 
    610                 615                 620                 


Leu Ser Pro Phe His Ala Pro Ala Gln Ser Pro Gly Leu His Gly Gly 
625                 630                 635                 640 


Ala Ala Gly Ser Arg Glu Gly Trp Ser Leu Leu Glu Glu Val Leu Glu 
                645                 650                 655     


Gln Gln Arg Leu Leu Gln Leu Gln His His Pro Ala Ala Ala Pro Gly 
            660                 665                 670         


Cys Ser Gln Ala Pro Gln Pro Ala Pro Ala Pro Phe Val Ile Ala Pro 
        675                 680                 685             


Cys Asp Gly Pro Gly Ala Ala Pro Leu Pro Ser Thr Leu Leu Thr Ser 
    690                 695                 700                 


Gly Leu Pro Leu Leu Pro Pro Pro Leu Leu Gln Thr Gly Ala Ser Pro 
705                 710                 715                 720 


Val Ala Ser Ala Ala Gln Leu Leu Asp Thr His Leu His Ile Gly Thr 
                725                 730                 735     


Gly Pro Thr Ala Leu Pro Ala Val Pro Pro Pro Arg Leu Ala Arg Leu 
            740                 745                 750         


Ala Pro Gly Cys Glu Pro Leu Gly Leu Leu Gln Gly Asp Cys Glu Met 
        755                 760                 765             


Glu Asp Leu Met Pro Cys Ser Leu Gly Thr Phe Val Leu Val Gln 
    770                 775                 780             


<210> 16
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 17
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 19
<211> 16
<212> PRT
<213> Rattus sp.

<400> 19
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 21
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 21
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 22
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 22
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 23
<211> 22
<212> RNA
<213> Homo sapiens 

<400> 23
ucagugcauc acagaacuuu gu                                                22


<210> 24
<211> 67
<212> RNA
<213> Homo sapiens

<400> 24
acuguguaca uuuggcauuu guguuauuau uuugcacugu uuucugucgu guguguuggg       60

augggau                                                                 67


<210> 25
<211> 72
<212> RNA
<213> Homo sapiens

<400> 25
uucuuucuga aaucgccgug uuacuguugc acugaugucc ggagagacag ugacagccuc       60

cgucagacuc cc                                                           72


<210> 26
<211> 67
<212> RNA
<213> Homo sapiens

<400> 26
acuguguaca uuuggcauuu guguuauuau uuuacaaugu uuucugucgu guguguuggg       60

augggau                                                                 67


<210> 27
<211> 72
<212> RNA
<213> Homo sapiens

<400> 27
uucuuucuga aaucgccgug uuacuguuac acugaugucc ggagagacag ugacagccuc       60

cgucagacuc cc                                                           72


<210> 28
<211> 69
<212> RNA
<213> Homo sapiens

<400> 28
cauuccaagc acuuuacgcu gucuguaaug ggaucuauuu uugcacugga auaucugaga       60

auugcaaaa                                                               69


<210> 29
<211> 69
<212> RNA
<213> Homo sapiens

<400> 29
cauuccaagc acuuuacgcu gucuguaaug ggaucuauuu uuacaaugga auaucugaga       60

auugcaaaa                                                               69


