                         SEQUENCE LISTING

<110>  PARDRIDGE, WILLIAM M
       BOADO, RUBEN J
 
<120>  METHODS AND COMPOSITIONS FOR INCREASING ENZYME ACTIVITY IN THE 
       CNS

<130>  28570-713.601

<150>  US 61/857140
<151>  2013-07-22

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gly Tyr Thr Phe Thr Asn Tyr Asp Ile His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Trp Ala Tyr 
1               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Arg Ala Ser Gln Asp Ile Gly Gly Asn Leu Tyr 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Leu Gln Tyr Ser Ser Ser Pro Trp Thr 
1               5                   


<210>  7
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460     


<210>  8
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Gly Asn Leu Tyr Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ser 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  9
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro His Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


Glu Leu 
        


<210>  10
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
465                 470                 475                 480 


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
                485                 490                 495     


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
            500                 505                 510         


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
        515                 520                 525             


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
    530                 535                 540                 


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
545                 550                 555                 560 


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
                565                 570                 575     


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
            580                 585                 590         


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
        595                 600                 605             


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
    610                 615                 620                 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
625                 630                 635                 640 


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
                645                 650                 655     


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
            660                 665                 670         


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
        675                 680                 685             


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
    690                 695                 700                 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
705                 710                 715                 720 


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
                725                 730                 735     


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
            740                 745                 750         


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
        755                 760                 765             


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
    770                 775                 780                 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
785                 790                 795                 800 


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
                805                 810                 815     


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
            820                 825                 830         


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
        835                 840                 845             


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
    850                 855                 860                 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
865                 870                 875                 880 


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
                885                 890                 895     


Thr Asp Pro His Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
            900                 905                 910         


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
        915                 920                 925             


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
    930                 935                 940                 


Glu Leu 
945     


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
cacgtccccg gaacgcactg ctg                                               23


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
tcacagctca ttgtggaggg gctg                                              24


<210>  13
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
gccgccacca tggagacccc cgcccagctg ctgttcctgt tgctgctttg gcttccagat       60

actaccggcg acatccagat gacccagtct ccatcctcct tatctgcctc tctgggagaa      120

agagtcagtc tcacttgtcg ggcaagtcag gacattggtg gtaacttata ctggcttcag      180

cagggaccag atggaactat taaacgcctg atctacgcca catccagttt agattctggt      240

gtccccaaaa ggttcagtgg cagtaggtct gggtcagatt attctctcac catcagcagc      300

cttgagtctg aagattttgt agactattac tgtctacagt attctagttc tccgtggacg      360

ttcggtggag gcacaaagct ggaaataaaa cgaactgtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


<210>  14
<211>  2850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc acgtccccgg aacgcactgc tgctcctcgc ggatgacgga     1440

ggctttgaga gtggcgcgta caacaacagc gccatcgcca ccccgcacct ggacgccttg     1500

gcccgccgca gcctcctctt tcgcaatgcc ttcacctcgg tcagcagctg ctctcccagc     1560

cgcgccagcc tcctcactgg cctgccccag catcagaatg ggatgtacgg gctgcaccag     1620

gacgtgcacc acttcaactc cttcgacaag gtgcggagcc tgccgctgct gctcagccaa     1680

gctggtgtgc gcacaggcat catcgggaag aagcacgtgg ggccggagac cgtgtacccg     1740

tttgactttg cgtacacgga ggagaatggc tccgtcctcc aggtggggcg gaacatcact     1800

agaattaagc tgctcgtccg gaaattcctg cagactcagg atgaccggcc tttcttcctc     1860

tacgtcgcct tccacgaccc ccaccgctgt gggcactccc agccccagta cggaaccttc     1920

tgtgagaagt ttggcaacgg agagagcggc atgggtcgta tcccagactg gaccccccag     1980

gcctacgacc cactggacgt gctggtgcct tacttcgtcc ccaacacccc ggcagcccga     2040

gccgacctgg ccgctcagta caccaccgtc ggccgcatgg accaaggagt tggactggtg     2100

ctccaggagc tgcgtgacgc cggtgtcctg aacgacacac tggtgatctt cacgtccgac     2160

aacgggatcc ccttccccag cggcaggacc aacctgtact ggccgggcac tgctgaaccc     2220

ttactggtgt catccccgga gcacccaaaa cgctggggcc aagtcagcga ggcctacgtg     2280

agcctcctag acctcacgcc caccatcttg gattggttct cgatcccgta ccccagctac     2340

gccatctttg gctcgaagac catccacctc actggccggt ccctcctgcc ggcgctggag     2400

gccgagcccc tctgggccac cgtctttggc agccagagcc accacgaggt caccatgtcc     2460

taccccatgc gctccgtgca gcaccggcac ttccgcctcg tgcacaacct caacttcaag     2520

atgccctttc ccatcgacca ggacttctac gtctcaccca ccttccagga cctcctgaac     2580

cgcaccacag ctggtcagcc cacgggctgg tacaaggacc tccgtcatta ctactaccgg     2640

gcgcgctggg agctctacga ccggagccgg gacccccacg agacccagaa cctggccacc     2700

gacccgcact ttgctcagct tctggagatg cttcgggacc agctggccaa gtggcagtgg     2760

gagacccacg acccctgggt gtgcgccccc gacggcgtcc tggaggagaa gctctctccc     2820

cagtgccagc ccctccacaa tgagctgtga                                      2850


<210>  15
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
gccgccacca tggttcgacc attgaactgc atcgtcgccg tgtcccaaaa tatggggatt       60

ggcaagaacg gagacctacc ctggcctccg ctcaggaacg agttcaagta cttccaaaga      120

atgaccacaa cctcttcagt ggaaggtaaa cagaatctgg tgattatggg taggaaaacc      180

tggttctcca ttcctgagaa gaatcgacct ttaaaggaca gaattaatat agttctcagt      240

agagaactca aagaaccacc acgaggagct cattttcttg ccaaaagttt ggatgatgcc      300

ttaagactta ttgaacaacc ggaattggca agtaaagtag acatggtttg gatagtcgga      360

ggcagttctg tttaccagga agccatgaat caaccaggcc acctcagact ctttgtgaca      420

aggatcatgc aggaatttga aagtgacacg tttttcccag aaattgattt ggggaaatat      480

aaacttctcc cagaataccc aggcgtcctc tctgaggtcc aggaggaaaa aggcatcaag      540

tataagtttg aagtctacga gaagaaagac taa                                   573


<210>  16
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  17
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Glu Ala Arg Glu Ala Ala Ala Val Arg Ala Leu Val Ala Arg Leu 
1               5                   10                  15      


Leu Gly Pro Gly Pro Ala Ala Asp Phe Ser Val Ser Val Glu Arg Ala 
            20                  25                  30          


Leu Ala Ala Lys Pro Gly Leu Asp Thr Tyr Ser Leu Gly Gly Gly Gly 
        35                  40                  45              


Ala Ala Arg Val Arg Val Arg Gly Ser Thr Gly Val Ala Ala Ala Ala 
    50                  55                  60                  


Gly Leu His Arg Tyr Leu Arg Asp Phe Cys Gly Cys His Val Ala Trp 
65                  70                  75                  80  


Ser Gly Ser Gln Leu Arg Leu Pro Arg Pro Leu Pro Ala Val Pro Gly 
                85                  90                  95      


Glu Leu Thr Glu Ala Thr Pro Asn Arg Tyr Arg Tyr Tyr Gln Asn Val 
            100                 105                 110         


Cys Thr Gln Ser Tyr Ser Phe Val Trp Trp Asp Trp Ala Arg Trp Glu 
        115                 120                 125             


Arg Glu Ile Asp Trp Met Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala 
    130                 135                 140                 


Trp Ser Gly Gln Glu Ala Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly 
145                 150                 155                 160 


Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu 
                165                 170                 175     


Ala Trp Gly Arg Met Gly Asn Leu His Thr Trp Asp Gly Pro Leu Pro 
            180                 185                 190         


Pro Ser Trp His Ile Lys Gln Leu Tyr Leu Gln His Arg Val Leu Asp 
        195                 200                 205             


Gln Met Arg Ser Phe Gly Met Thr Pro Val Leu Pro Ala Phe Ala Gly 
    210                 215                 220                 


His Val Pro Glu Ala Val Thr Arg Val Phe Pro Gln Val Asn Val Thr 
225                 230                 235                 240 


Lys Met Gly Ser Trp Gly His Phe Asn Cys Ser Tyr Ser Cys Ser Phe 
                245                 250                 255     


Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro Ile Ile Gly Ser Leu Phe 
            260                 265                 270         


Leu Arg Glu Leu Ile Lys Glu Phe Gly Thr Asp His Ile Tyr Gly Ala 
        275                 280                 285             


Asp Thr Phe Asn Glu Met Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu 
    290                 295                 300                 


Ala Ala Ala Thr Thr Ala Val Tyr Glu Ala Met Thr Ala Val Asp Thr 
305                 310                 315                 320 


Glu Ala Val Trp Leu Leu Gln Gly Trp Leu Phe Gln His Gln Pro Gln 
                325                 330                 335     


Phe Trp Gly Pro Ala Gln Ile Arg Ala Val Leu Gly Ala Val Pro Arg 
            340                 345                 350         


Gly Arg Leu Leu Val Leu Asp Leu Phe Ala Glu Ser Gln Pro Val Tyr 
        355                 360                 365             


Thr Arg Thr Ala Ser Phe Gln Gly Gln Pro Phe Ile Trp Cys Met Leu 
    370                 375                 380                 


His Asn Phe Gly Gly Asn His Gly Leu Phe Gly Ala Leu Glu Ala Val 
385                 390                 395                 400 


Asn Gly Gly Pro Glu Ala Ala Arg Leu Phe Pro Asn Ser Thr Met Val 
                405                 410                 415     


Gly Thr Gly Met Ala Pro Glu Gly Ile Ser Gln Asn Glu Val Val Tyr 
            420                 425                 430         


Ser Leu Met Ala Glu Leu Gly Trp Arg Lys Asp Pro Val Pro Asp Leu 
        435                 440                 445             


Ala Ala Trp Val Thr Ser Phe Ala Ala Arg Arg Tyr Gly Val Ser His 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Trp Arg Leu Leu Leu Arg Ser Val Tyr Asn 
465                 470                 475                 480 


Cys Ser Gly Glu Ala Cys Arg Gly His Asn Arg Ser Pro Leu Val Arg 
                485                 490                 495     


Arg Pro Ser Leu Gln Met Asn Thr Ser Ile Trp Tyr Asn Arg Ser Asp 
            500                 505                 510         


Val Phe Glu Ala Trp Arg Leu Leu Leu Thr Ser Ala Pro Ser Leu Ala 
        515                 520                 525             


Thr Ser Pro Ala Phe Arg Tyr Asp Leu Leu Asp Leu Thr Arg Gln Ala 
    530                 535                 540                 


Val Gln Glu Leu Val Ser Leu Tyr Tyr Glu Glu Ala Arg Ser Ala Tyr 
545                 550                 555                 560 


Leu Ser Lys Glu Leu Ala Ser Leu Leu Arg Ala Gly Gly Val Leu Ala 
                565                 570                 575     


Tyr Glu Leu Leu Pro Ala Leu Asp Glu Val Leu Ala Ser Asp Ser Arg 
            580                 585                 590         


Phe Leu Leu Gly Ser Trp Leu Glu Gln Ala Arg Ala Ala Ala Val Ser 
        595                 600                 605             


Glu Ala Glu Ala Asp Phe Tyr Glu Gln Asn Ser Arg Tyr Gln Leu Thr 
    610                 615                 620                 


Leu Trp Gly Pro Glu Gly Asn Ile Leu Asp Tyr Ala Asn Lys Gln Leu 
625                 630                 635                 640 


Ala Gly Leu Val Ala Asn Tyr Tyr Thr Pro Arg Trp Arg Leu Phe Leu 
                645                 650                 655     


Glu Ala Leu Val Asp Ser Val Ala Gln Gly Ile Pro Phe Gln Gln His 
            660                 665                 670         


Gln Phe Asp Lys Asn Val Phe Gln Leu Glu Gln Ala Phe Val Leu Ser 
        675                 680                 685             


Lys Gln Arg Tyr Pro Ser Gln Pro Arg Gly Asp Thr Val Asp Leu Ala 
    690                 695                 700                 


Lys Lys Ile Phe Leu Lys Tyr Tyr Pro Arg Trp Val Ala Gly Ser Trp 
705                 710                 715                 720 


<210>  18
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Asp Glu Ala Arg Glu Ala Ala Ala Val Arg Ala Leu Val Ala Arg Leu 
465                 470                 475                 480 


Leu Gly Pro Gly Pro Ala Ala Asp Phe Ser Val Ser Val Glu Arg Ala 
                485                 490                 495     


Leu Ala Ala Lys Pro Gly Leu Asp Thr Tyr Ser Leu Gly Gly Gly Gly 
            500                 505                 510         


Ala Ala Arg Val Arg Val Arg Gly Ser Thr Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Gly Leu His Arg Tyr Leu Arg Asp Phe Cys Gly Cys His Val Ala Trp 
    530                 535                 540                 


Ser Gly Ser Gln Leu Arg Leu Pro Arg Pro Leu Pro Ala Val Pro Gly 
545                 550                 555                 560 


Glu Leu Thr Glu Ala Thr Pro Asn Arg Tyr Arg Tyr Tyr Gln Asn Val 
                565                 570                 575     


Cys Thr Gln Ser Tyr Ser Phe Val Trp Trp Asp Trp Ala Arg Trp Glu 
            580                 585                 590         


Arg Glu Ile Asp Trp Met Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala 
        595                 600                 605             


Trp Ser Gly Gln Glu Ala Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly 
    610                 615                 620                 


Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu 
625                 630                 635                 640 


Ala Trp Gly Arg Met Gly Asn Leu His Thr Trp Asp Gly Pro Leu Pro 
                645                 650                 655     


Pro Ser Trp His Ile Lys Gln Leu Tyr Leu Gln His Arg Val Leu Asp 
            660                 665                 670         


Gln Met Arg Ser Phe Gly Met Thr Pro Val Leu Pro Ala Phe Ala Gly 
        675                 680                 685             


His Val Pro Glu Ala Val Thr Arg Val Phe Pro Gln Val Asn Val Thr 
    690                 695                 700                 


Lys Met Gly Ser Trp Gly His Phe Asn Cys Ser Tyr Ser Cys Ser Phe 
705                 710                 715                 720 


Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro Ile Ile Gly Ser Leu Phe 
                725                 730                 735     


Leu Arg Glu Leu Ile Lys Glu Phe Gly Thr Asp His Ile Tyr Gly Ala 
            740                 745                 750         


Asp Thr Phe Asn Glu Met Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu 
        755                 760                 765             


Ala Ala Ala Thr Thr Ala Val Tyr Glu Ala Met Thr Ala Val Asp Thr 
    770                 775                 780                 


Glu Ala Val Trp Leu Leu Gln Gly Trp Leu Phe Gln His Gln Pro Gln 
785                 790                 795                 800 


Phe Trp Gly Pro Ala Gln Ile Arg Ala Val Leu Gly Ala Val Pro Arg 
                805                 810                 815     


Gly Arg Leu Leu Val Leu Asp Leu Phe Ala Glu Ser Gln Pro Val Tyr 
            820                 825                 830         


Thr Arg Thr Ala Ser Phe Gln Gly Gln Pro Phe Ile Trp Cys Met Leu 
        835                 840                 845             


His Asn Phe Gly Gly Asn His Gly Leu Phe Gly Ala Leu Glu Ala Val 
    850                 855                 860                 


Asn Gly Gly Pro Glu Ala Ala Arg Leu Phe Pro Asn Ser Thr Met Val 
865                 870                 875                 880 


Gly Thr Gly Met Ala Pro Glu Gly Ile Ser Gln Asn Glu Val Val Tyr 
                885                 890                 895     


Ser Leu Met Ala Glu Leu Gly Trp Arg Lys Asp Pro Val Pro Asp Leu 
            900                 905                 910         


Ala Ala Trp Val Thr Ser Phe Ala Ala Arg Arg Tyr Gly Val Ser His 
        915                 920                 925             


Pro Asp Ala Gly Ala Ala Trp Arg Leu Leu Leu Arg Ser Val Tyr Asn 
    930                 935                 940                 


Cys Ser Gly Glu Ala Cys Arg Gly His Asn Arg Ser Pro Leu Val Arg 
945                 950                 955                 960 


Arg Pro Ser Leu Gln Met Asn Thr Ser Ile Trp Tyr Asn Arg Ser Asp 
                965                 970                 975     


Val Phe Glu Ala Trp Arg Leu Leu Leu Thr Ser Ala Pro Ser Leu Ala 
            980                 985                 990         


Thr Ser Pro Ala Phe Arg Tyr Asp  Leu Leu Asp Leu Thr  Arg Gln Ala 
        995                 1000                 1005             


Val Gln  Glu Leu Val Ser Leu  Tyr Tyr Glu Glu Ala  Arg Ser Ala 
    1010                 1015                 1020             


Tyr Leu  Ser Lys Glu Leu Ala  Ser Leu Leu Arg Ala  Gly Gly Val 
    1025                 1030                 1035             


Leu Ala  Tyr Glu Leu Leu Pro  Ala Leu Asp Glu Val  Leu Ala Ser 
    1040                 1045                 1050             


Asp Ser  Arg Phe Leu Leu Gly  Ser Trp Leu Glu Gln  Ala Arg Ala 
    1055                 1060                 1065             


Ala Ala  Val Ser Glu Ala Glu  Ala Asp Phe Tyr Glu  Gln Asn Ser 
    1070                 1075                 1080             


Arg Tyr  Gln Leu Thr Leu Trp  Gly Pro Glu Gly Asn  Ile Leu Asp 
    1085                 1090                 1095             


Tyr Ala  Asn Lys Gln Leu Ala  Gly Leu Val Ala Asn  Tyr Tyr Thr 
    1100                 1105                 1110             


Pro Arg  Trp Arg Leu Phe Leu  Glu Ala Leu Val Asp  Ser Val Ala 
    1115                 1120                 1125             


Gln Gly  Ile Pro Phe Gln Gln  His Gln Phe Asp Lys  Asn Val Phe 
    1130                 1135                 1140             


Gln Leu  Glu Gln Ala Phe Val  Leu Ser Lys Gln Arg  Tyr Pro Ser 
    1145                 1150                 1155             


Gln Pro  Arg Gly Asp Thr Val  Asp Leu Ala Lys Lys  Ile Phe Leu 
    1160                 1165                 1170             


Lys Tyr  Tyr Pro Arg Trp Val  Ala Gly Ser Trp 
    1175                 1180                 


<210>  19
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Ala Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp Ala Gln Ala 
1               5                   10                  15      


Ala Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu Leu Lys Met 
            20                  25                  30          


Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu 
        35                  40                  45              


Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val 
    50                  55                  60                  


Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala 
65                  70                  75                  80  


Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp 
                85                  90                  95      


Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu 
            100                 105                 110         


Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser 
        115                 120                 125             


Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn 
    130                 135                 140                 


Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val 
145                 150                 155                 160 


Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp 
                165                 170                 175     


Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser 
            180                 185                 190         


Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln 
        195                 200                 205             


Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val 
    210                 215                 220                 


Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr 
225                 230                 235                 240 


Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu 
                245                 250                 255     


Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser 
            260                 265                 270         


Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys 
        275                 280                 285             


Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys 
    290                 295                 300                 


Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser 
305                 310                 315                 320 


Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr 
                325                 330                 335     


Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro 
            340                 345                 350         


Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr 
        355                 360                 365             


Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp 
    370                 375                 380                 


Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr 
385                 390                 395                 400 


Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr 
                405                 410                 415     


Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His 
            420                 425                 430         


Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala 
        435                 440                 445             


Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala 
    450                 455                 460                 


Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg 
465                 470                 475                 480 


Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly 
                485                 490                 495     


Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile 
            500                 505                 510         


Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser 
        515                 520                 525             


Ser Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp Val 
    530                 535                 540                 


Lys Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn Ser 
545                 550                 555                 560 


Ile Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro Phe 
                565                 570                 575     


Gln Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His Leu Thr Gln 
            580                 585                 590         


Asn Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu Tyr 
        595                 600                 605             


Arg Lys Lys Ile Phe Trp Lys Ile 
    610                 615     


<210>  20
<211>  1080
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Ala Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp Ala Gln Ala 
465                 470                 475                 480 


Ala Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu Leu Lys Met 
                485                 490                 495     


Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu 
            500                 505                 510         


Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val 
        515                 520                 525             


Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala 
    530                 535                 540                 


Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp 
545                 550                 555                 560 


Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu 
                565                 570                 575     


Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser 
            580                 585                 590         


Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn 
        595                 600                 605             


Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val 
    610                 615                 620                 


Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp 
625                 630                 635                 640 


Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser 
                645                 650                 655     


Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln 
            660                 665                 670         


Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val 
        675                 680                 685             


Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr 
    690                 695                 700                 


Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu 
705                 710                 715                 720 


Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser 
                725                 730                 735     


Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys 
            740                 745                 750         


Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys 
        755                 760                 765             


Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser 
    770                 775                 780                 


Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr 
785                 790                 795                 800 


Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro 
                805                 810                 815     


Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr 
            820                 825                 830         


Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp 
        835                 840                 845             


Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr 
    850                 855                 860                 


Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr 
865                 870                 875                 880 


Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His 
                885                 890                 895     


Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala 
            900                 905                 910         


Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala 
        915                 920                 925             


Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg 
    930                 935                 940                 


Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly 
945                 950                 955                 960 


Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile 
                965                 970                 975     


Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser 
            980                 985                 990         


Ser Phe Ala Phe Phe Ile Leu Leu  Val Leu Tyr Pro Val  Val Asp Val 
        995                 1000                 1005             


Lys Gly  Leu Trp Thr Gly Thr  Pro Phe Phe Tyr Pro  Gly Met Asn 
    1010                 1015                 1020             


Ser Ile  Leu Val Tyr Val Gly  His Glu Val Phe Glu  Asn Tyr Phe 
    1025                 1030                 1035             


Pro Phe  Gln Trp Lys Leu Lys  Asp Asn Gln Ser His  Lys Glu His 
    1040                 1045                 1050             


Leu Thr  Gln Asn Ile Val Ala  Thr Ala Leu Trp Val  Leu Ile Ala 
    1055                 1060                 1065             


Tyr Ile  Leu Tyr Arg Lys Lys  Ile Phe Trp Lys Ile  
    1070                 1075                 1080 


<210>  21
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn Val Val Leu Leu 
1               5                   10                  15      


Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met Thr Pro Leu Lys 
            20                  25                  30          


Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr Phe Ser Ser Ala 
        35                  40                  45              


Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala Ser Ile Leu Thr 
    50                  55                  60                  


Gly Lys Tyr Pro His Asn His His Val Val Asn Asn Thr Leu Glu Gly 
65                  70                  75                  80  


Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu Pro Asn Thr Phe 
                85                  90                  95      


Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr Phe Phe Ala Gly 
            100                 105                 110         


Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly Gly Leu Glu His 
        115                 120                 125             


Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu Lys Asn Ser Lys 
    130                 135                 140                 


Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly 
145                 150                 155                 160 


Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser 
                165                 170                 175     


Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met 
            180                 185                 190         


Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr 
        195                 200                 205             


Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn 
    210                 215                 220                 


Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro 
225                 230                 235                 240 


Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg 
                245                 250                 255     


Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys 
            260                 265                 270         


Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr 
        275                 280                 285             


Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys 
    290                 295                 300                 


Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly 
305                 310                 315                 320 


Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu Val Ala Asn Ile 
                325                 330                 335     


Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr Asp Leu Asn Lys 
            340                 345                 350         


Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu Arg Gly Ala Ser 
        355                 360                 365             


Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly 
    370                 375                 380                 


Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser 
385                 390                 395                 400 


Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr 
                405                 410                 415     


Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu 
            420                 425                 430         


Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp 
        435                 440                 445             


Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu 
    450                 455                 460                 


Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro 
465                 470                 475                 480 


Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr Arg Phe Asp Pro 
                485                 490                 495     


Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr Arg Arg Phe Ser 
            500                 505                 510         


Lys His Leu Leu 
        515     


<210>  22
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn Val Val Leu Leu 
465                 470                 475                 480 


Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met Thr Pro Leu Lys 
                485                 490                 495     


Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr Phe Ser Ser Ala 
            500                 505                 510         


Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala Ser Ile Leu Thr 
        515                 520                 525             


Gly Lys Tyr Pro His Asn His His Val Val Asn Asn Thr Leu Glu Gly 
    530                 535                 540                 


Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu Pro Asn Thr Phe 
545                 550                 555                 560 


Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr Phe Phe Ala Gly 
                565                 570                 575     


Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly Gly Leu Glu His 
            580                 585                 590         


Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu Lys Asn Ser Lys 
        595                 600                 605             


Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly 
    610                 615                 620                 


Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser 
625                 630                 635                 640 


Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met 
                645                 650                 655     


Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr 
            660                 665                 670         


Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn 
        675                 680                 685             


Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro 
    690                 695                 700                 


Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg 
705                 710                 715                 720 


Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys 
                725                 730                 735     


Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr 
            740                 745                 750         


Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys 
        755                 760                 765             


Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly 
    770                 775                 780                 


Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu Val Ala Asn Ile 
785                 790                 795                 800 


Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr Asp Leu Asn Lys 
                805                 810                 815     


Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu Arg Gly Ala Ser 
            820                 825                 830         


Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly 
        835                 840                 845             


Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser 
    850                 855                 860                 


Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr 
865                 870                 875                 880 


Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu 
                885                 890                 895     


Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp 
            900                 905                 910         


Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu 
        915                 920                 925             


Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro 
    930                 935                 940                 


Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr Arg Phe Asp Pro 
945                 950                 955                 960 


Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr Arg Arg Phe Ser 
                965                 970                 975     


Lys His Leu Leu 
            980 


<210>  23
<211>  3564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc agacgaggcc cgggaggcgg cggccgtgcg ggcgctcgtg     1440

gcccggctgc tggggccagg ccccgcggcc gacttctccg tgtcggtgga gcgcgctctg     1500

gctgccaagc cgggcttgga cacctacagc ctgggcggcg gcggcgcggc gcgcgtgcgg     1560

gtgcgcggct ccacgggcgt ggcggccgcc gcggggctgc accgctacct gcgcgacttc     1620

tgtggctgcc acgtggcctg gtccggctct cagctgcgcc tgccgcggcc actgccagcc     1680

gtgccggggg agctgaccga ggccacgccc aacaggtacc gctattacca gaatgtgtgc     1740

acgcaaagct actctttcgt gtggtgggac tgggcccgct gggagcgaga gatagactgg     1800

atggcgctga atggcatcaa cctggcactg gcctggagcg gccaggaggc catctggcag     1860

cgggtgtacc tggccttggg cctgacccag gcagagatca atgagttctt tactggtcct     1920

gccttcctgg cctgggggcg aatgggcaac ctgcacacct gggatggccc cctgcccccc     1980

tcctggcaca tcaagcagct ttacctgcag caccgggtcc tggaccagat gcgctccttc     2040

ggcatgaccc cagtgctgcc tgcattcgcg gggcatgttc ccgaggctgt caccagggtg     2100

ttccctcagg tcaatgtcac gaagatgggc agttggggcc actttaactg ttcctactcc     2160

tgctccttcc ttctggctcc ggaagacccc atattcccca tcatcgggag cctcttcctg     2220

cgagagctga tcaaagagtt tggcacagac cacatctatg gggccgacac tttcaatgag     2280

atgcagccac cttcctcaga gccctcctac cttgccgcag ccaccactgc cgtctatgag     2340

gccatgactg cagtggatac tgaggctgtg tggctgctcc aaggctggct cttccagcac     2400

cagccgcagt tctgggggcc cgcccagatc agggctgtgc tgggagctgt gccccgtggc     2460

cgcctcctgg ttctggacct gtttgctgag agccagcctg tgtatacccg cactgcctcc     2520

ttccagggcc agcccttcat ctggtgcatg ctgcacaact ttgggggaaa ccatggtctt     2580

tttggagccc tagaggctgt gaacggaggc ccagaagctg cccgcctctt ccccaactcc     2640

accatggtag gcacgggcat ggcccccgag ggcatcagcc agaacgaagt ggtctattcc     2700

ctcatggctg agctgggctg gcgaaaggac ccagtgccag atttggcagc ctgggtgacc     2760

agctttgccg cccggcggta tggggtctcc cacccggacg caggggcagc gtggaggcta     2820

ctgctccgga gtgtgtacaa ctgctccggg gaggcctgca ggggccacaa tcgtagcccg     2880

ctggtcaggc ggccgtccct acagatgaat accagcatct ggtacaaccg atctgatgtg     2940

tttgaggcct ggcggctgct gctcacatct gctccctccc tggccaccag ccccgccttc     3000

cgctacgacc tgctggacct cactcggcag gcagtgcagg agctggtcag cttgtactat     3060

gaggaggcaa gaagcgccta cctgagcaag gagctggcct ccctgttgag ggctggaggc     3120

gtcctggcct atgagctgct gccggcactg gacgaggtgc tggctagtga cagccgcttc     3180

ttgctgggca gctggctaga gcaggcccga gcagcggcag tcagtgaggc cgaggccgat     3240

ttctacgagc agaacagccg ctaccagctg accttgtggg ggccagaagg caacatcctg     3300

gactatgcca acaagcagct ggcggggttg gtggccaact actacacccc tcgctggcgg     3360

cttttcctgg aggcgctggt tgacagtgtg gcccagggca tccctttcca acagcaccag     3420

tttgacaaaa atgtcttcca actggagcag gccttcgttc tcagcaagca gaggtacccc     3480

agccagccgc gaggagacac tgtggacctg gccaagaaga tcttcctcaa atattacccc     3540

cgctgggtgg ccggctcttg gtga                                            3564


<210>  24
<211>  3252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc agccgcgctg ctggcccccg gcggctcttc ggggcgcgat     1440

gcccaggccg cgccgccacg agacttagac aaaaaaagac atgcagagct gaagatggat     1500

caggctttgc tactcatcca taatgaactt ctctggacca acttgaccgt ctactggaaa     1560

tctgaatgct gttatcactg cttgtttcag gttctggtaa acgttcctca gagtccaaaa     1620

gcagggaagc ctagtgctgc agctgcctct gtcagcaccc agcacggatc tatcctgcag     1680

ctgaacgaca ccttggaaga gaaagaagtt tgtaggttgg aatacagatt tggagaattt     1740

ggaaactatt ctctcttggt aaagaacatc cataatggag ttagtgaaat tgcctgtgac     1800

ctggctgtga acgaggatcc agttgatagt aaccttcctg tgagcattgc attccttatt     1860

ggtcttgctg tcatcattgt gatatccttt ctgaggctct tgttgagttt ggatgacttt     1920

aacaattgga tttctaaagc cataagttct cgagaaactg atcgcctcat caattctgag     1980

ctgggatctc ccagcaggac agaccctctc gatggtgatg ttcagccagc aacgtggcgt     2040

ctatctgccc tgccgccccg cctccgcagc gtggacacct tcagggggat tgctcttata     2100

ctcatggtct ttgtcaatta tggaggagga aaatattggt acttcaaaca tgcaagttgg     2160

aatgggctga cagtggctga cctcgtgttc ccgtggtttg tatttattat gggatcttcc     2220

atttttctat cgatgacttc tatactgcaa cgggggtgtt caaaattcag attgctgggg     2280

aagattgcat ggaggagttt cctgttaatc tgcataggaa ttatcattgt gaatcccaat     2340

tattgccttg gtccattgtc ttgggacaag gtgcgcattc ctggtgtgct gcagcgattg     2400

ggagtgacat actttgtggt tgctgtgttg gagctcctct ttgctaaacc tgtgcctgaa     2460

cattgtgcct cggagaggag ctgcctttct cttcgagaca tcacgtccag ctggccccag     2520

tggctgctca tcctggtgct ggaaggcctg tggctgggct tgacattcct cctgccagtc     2580

cctgggtgcc ctactggtta tcttggtcct gggggcattg gagattttgg caagtatcca     2640

aattgcactg gaggagctgc aggctacatc gaccgcctgc tgctgggaga cgatcacctt     2700

taccagcacc catcttctgc tgtactttac cacaccgagg tggcctatga ccccgagggc     2760

atcctgggca ccatcaactc catcgtgatg gcctttttag gagttcaggc aggaaaaata     2820

ctattgtatt acaaggctcg gaccaaagac atcctgattc gattcactgc ttggtgttgt     2880

attcttgggc tcatttctgt tgctctgacg aaggtttctg aaaatgaagg ctttattcca     2940

gtaaacaaaa atctctggtc cctttcgtat gtcactacgc tcagttcttt tgccttcttc     3000

atcctgctgg tcctgtaccc agttgtggat gtgaaggggc tgtggacagg aaccccattc     3060

ttttatccag gaatgaattc cattctggta tatgtcggcc acgaggtgtt tgagaactac     3120

ttcccctttc agtggaagct gaaggacaac cagtcccaca aggagcacct gactcagaac     3180

atcgtcgcca ctgccctctg ggtgctcatt gcctacatcc tctatagaaa gaagattttt     3240

tggaaaatct ga                                                         3252


<210>  25
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc agtcttcggg gtggctgcgg gaacccggag gcccaacgtg     1440

gtgctgctcc tcacggacga ccaggacgaa gtgctcggcg gcatgacacc gctaaagaaa     1500

accaaagctc tcatcggaga gatggggatg actttttcca gtgcttatgt gccaagtgct     1560

ctctgctgcc ccagcagagc cagtatcctg acaggaaagt acccacataa tcatcacgtt     1620

gtgaacaaca ctctggaggg gaactgcagt agtaagtcct ggcagaagat ccaagaacca     1680

aatactttcc cagcaattct cagatcaatg tgtggttatc agaccttttt tgcagggaaa     1740

tatttaaatg agtacggagc cccagatgca ggtggactag aacacgttcc tctgggttgg     1800

agttactggt atgccttgga aaagaattct aagtattata attacaccct gtctatcaat     1860

gggaaggcac ggaagcatgg tgaaaactat agtgtggact acctgacaga tgttttggct     1920

aatgtctcct tggactttct ggactacaag tccaactttg agcccttctt catgatgatc     1980

gccactccag cgcctcattc gccttggaca gctgcacctc agtaccagaa ggctttccag     2040

aatgtctttg caccaagaaa caagaacttc aacatccatg gaacgaacaa gcactggtta     2100

attaggcaag ccaagactcc aatgactaat tcttcaatac agtttttaga taatgcattt     2160

aggaaaaggt ggcaaactct cctctcagtt gatgaccttg tggagaaact ggtcaagagg     2220

ctggagttca ctggggagct caacaacact tacatcttct atacctcaga caatggctat     2280

cacacaggac agttttcctt gccaatagac aagagacagc tgtatgagtt tgatatcaaa     2340

gttccactgt tggttcgagg acctgggatc aaaccaaatc agacaagcaa gatgctggtt     2400

gccaacattg acttgggtcc tactattttg gacattgctg gctacgacct aaataagaca     2460

cagatggatg ggatgtcctt attgcccatt ttgagaggtg ccagtaactt gacctggcga     2520

tcagatgtcc tggtggaata ccaaggagaa ggccgtaacg tcactgaccc aacatgccct     2580

tccctgagtc ctggcgtatc tcaatgcttc ccagactgtg tatgtgaaga tgcttataac     2640

aatacctatg cctgtgtgag gacaatgtca gcattgtgga atttgcagta ttgcgagttt     2700

gatgaccagg aggtgtttgt agaagtctat aatctgactg cagacccaga ccagatcact     2760

aacattgcta aaaccataga cccagagctt ttaggaaaga tgaactatcg gttaatgatg     2820

ttacagtcct gttctgggcc aacctgtcgc actccagggg tttttgaccc cggatacagg     2880

tttgaccccc gtctcatgtt cagcaatcgc ggcagtgtca ggactcgaag attttccaaa     2940

catcttctgt ag                                                         2952


