                         SEQUENCE LISTING

<110>  The University Court of the University of Edinburgh
 
<120>  Antiviral Compositions, Methods and Animals

<130>  P209196WO

<150>  GB1313235.2
<151>  2013-07-24

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1115
<212>  PRT
<213>  Sus scrofa

<400>  1

Met Asp Lys Leu Arg Met Val Leu His Glu Asn Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg Cys Ser Ala His Leu Ser Ser Phe Thr Phe Ala Val Val 
            20                  25                  30          


Ala Val Leu Ser Ala Cys Leu Val Thr Ser Ser Leu Gly Gly Lys Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Thr Gly Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Asp Met Asp Val Val Ser Val Val Cys Arg Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Thr Gly Trp Ala Asn Phe Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Asn Cys Thr His Gln Gln 
    130                 135                 140                 


Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asp Leu Glu Met Arg Leu 
145                 150                 155                 160 


Val Asn Gly Gly Asn Arg Cys Leu Gly Arg Ile Glu Val Lys Phe Gln 
                165                 170                 175     


Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asn His Ala 
            180                 185                 190         


Ser Val Val Cys Lys Gln Leu Glu Cys Gly Ser Ala Val Ser Phe Ser 
        195                 200                 205             


Gly Ser Ala Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp Asp 
    210                 215                 220                 


Leu Val Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His Glu 
225                 230                 235                 240 


Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val Ile 
                245                 250                 255     


Cys Leu Asn Gly Ala Asp Leu Lys Leu Arg Val Val Asp Gly Val Thr 
            260                 265                 270         


Glu Cys Ser Gly Arg Leu Glu Val Lys Phe Gln Gly Glu Trp Gly Thr 
        275                 280                 285             


Ile Cys Asp Asp Gly Trp Asp Ser Asp Asp Ala Ala Val Ala Cys Lys 
    290                 295                 300                 


Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn Ala 
305                 310                 315                 320 


Ser Glu Gly Thr Gly His Ile Trp Leu Asp Ser Val Ser Cys His Gly 
                325                 330                 335     


His Glu Ser Ala Leu Trp Gln Cys Arg His His Glu Trp Gly Lys His 
            340                 345                 350         


Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly Ser 
        355                 360                 365             


Asp Leu Glu Leu Arg Leu Lys Gly Gly Gly Ser His Cys Ala Gly Thr 
    370                 375                 380                 


Val Glu Val Glu Ile Gln Lys Leu Val Gly Lys Val Cys Asp Arg Ser 
385                 390                 395                 400 


Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys Gly 
                405                 410                 415     


Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Thr Lys Ala Thr 
            420                 425                 430         


Asn Thr Trp Leu Phe Val Ser Ser Cys Asn Gly Asn Glu Thr Ser Leu 
        435                 440                 445             


Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Ser Cys Asp His Tyr 
    450                 455                 460                 


Asp Glu Ala Lys Ile Thr Cys Ser Ala His Arg Lys Pro Arg Leu Val 
465                 470                 475                 480 


Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Gln His Gly Asp 
                485                 490                 495     


Thr Trp Gly Thr Val Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala Ser 
            500                 505                 510         


Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Leu Leu Gly 
        515                 520                 525             


Gly Ala His Phe Gly Glu Gly Ser Gly Gln Ile Trp Ala Glu Glu Phe 
    530                 535                 540                 


Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala Pro 
545                 550                 555                 560 


Arg Pro Asp Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val Cys 
                565                 570                 575     


Ser Arg Tyr Thr Gln Ile Arg Leu Val Asn Gly Lys Thr Pro Cys Glu 
            580                 585                 590         


Gly Arg Val Glu Leu Asn Ile Leu Gly Ser Trp Gly Ser Leu Cys Asn 
        595                 600                 605             


Ser His Trp Asp Met Glu Asp Ala His Val Leu Cys Gln Gln Leu Lys 
    610                 615                 620                 


Cys Gly Val Ala Leu Ser Ile Pro Arg Gly Ala Pro Phe Gly Lys Gly 
625                 630                 635                 640 


Ser Glu Gln Val Trp Arg His Met Phe His Cys Thr Gly Thr Glu Lys 
                645                 650                 655     


His Met Gly Asp Cys Ser Val Thr Ala Leu Gly Ala Ser Leu Cys Ser 
            660                 665                 670         


Ser Gly Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln Thr 
        675                 680                 685             


Leu Ser Pro Cys Asn Ser Ser Ser Ser Asp Pro Ser Ser Ser Ile Ile 
    690                 695                 700                 


Ser Glu Glu Asn Gly Val Ala Cys Ile Gly Ser Gly Gln Leu Arg Leu 
705                 710                 715                 720 


Val Asp Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Val Tyr His Glu 
                725                 730                 735     


Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Asn Asp Ala 
            740                 745                 750         


His Val Val Cys Lys Gln Leu Ser Cys Gly Trp Ala Ile Asn Ala Thr 
        755                 760                 765             


Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp Glu 
    770                 775                 780                 


Ile Asn Cys Asn Gly Lys Glu Ser His Ile Trp Gln Cys His Ser His 
785                 790                 795                 800 


Gly Trp Gly Arg His Asn Cys Arg His Lys Glu Asp Ala Gly Val Ile 
                805                 810                 815     


Cys Ser Glu Phe Met Ser Leu Arg Leu Ile Ser Glu Asn Ser Arg Glu 
            820                 825                 830         


Thr Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly Ser 
        835                 840                 845             


Val Gly Arg Asn Ser Met Ser Pro Ala Thr Val Gly Val Val Cys Arg 
    850                 855                 860                 


Gln Leu Gly Cys Ala Asp Arg Gly Asp Ile Ser Pro Ala Ser Ser Asp 
865                 870                 875                 880 


Lys Thr Val Ser Arg His Met Trp Val Asp Asn Val Gln Cys Pro Lys 
                885                 890                 895     


Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Lys Lys Arg 
            900                 905                 910         


Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Ala Asn Lys Ile 
        915                 920                 925             


Arg Leu Gln Glu Gly Asn Thr Asn Cys Ser Gly Arg Val Glu Ile Trp 
    930                 935                 940                 


Tyr Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu Glu 
945                 950                 955                 960 


Asp Ala Gln Val Val Cys Arg Gln Leu Gly Cys Gly Ser Ala Leu Glu 
                965                 970                 975     


Ala Gly Lys Glu Ala Ala Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu 
            980                 985                 990         


Asn Glu Val Lys Cys Lys Gly Asn  Glu Thr Ser Leu Trp  Asp Cys Pro 
        995                 1000                 1005             


Ala Arg  Ser Trp Gly His Ser  Asp Cys Gly His Lys  Glu Asp Ala 
    1010                 1015                 1020             


Ala Val  Thr Cys Ser Glu Ile  Ala Lys Ser Arg Glu  Ser Leu His 
    1025                 1030                 1035             


Ala Thr  Gly Arg Ser Ser Phe  Val Ala Leu Ala Ile  Phe Gly Val 
    1040                 1045                 1050             


Ile Leu  Leu Ala Cys Leu Ile  Ala Phe Leu Ile Trp  Thr Gln Lys 
    1055                 1060                 1065             


Arg Arg  Gln Arg Gln Arg Leu  Ser Val Phe Ser Gly  Gly Glu Asn 
    1070                 1075                 1080             


Ser Val  His Gln Ile Gln Tyr  Arg Glu Met Asn Ser  Cys Leu Lys 
    1085                 1090                 1095             


Ala Asp  Glu Thr Asp Met Leu  Asn Pro Ser Gly Asp  His Ser Glu 
    1100                 1105                 1110             


Val Gln  
    1115 


<210>  2
<211>  3399
<212>  DNA
<213>  Sus scrofa

<400>  2
atggtgctac ttgaagactc tggatctgca gactttagaa gatgttctgc ccatttaagt       60

tccttcactt ttgctgtagt cgctgttctc agtgcctgct tggtcactag ttctcttgga      120

ggaaaagaca aggagctgag gctaacgggt ggtgaaaaca agtgctctgg aagagtggag      180

gtgaaagtgc aggaggagtg gggaactgtg tgtaataatg gctgggacat ggatgtggtc      240

tctgttgttt gtaggcagct gggatgtcca actgctatca aagccactgg atgggctaat      300

tttagtgcag gttctggacg catttggatg gatcatgttt cttgtcgagg gaatgagtca      360

gctctctggg actgcaaaca tgatggatgg ggaaagcata actgtactca ccaacaggat      420

gctggagtaa cctgctcaga tggatctgat ttagagatga ggctggtgaa tggaggaaac      480

cggtgcttag gaagaataga agtcaaattt caagagcggt ggggaacagt gtgtgatgat      540

aacttcaaca taaatcatgc ttctgtggtt tgtaaacaac ttgaatgtgg aagtgctgtc      600

agtttctctg gttcagctaa ttttggagaa ggttctggac caatctggtt tgatgatctt      660

gtatgcaatg gaaatgagtc agctctctgg aactgcaaac atgaaggatg gggaaagcac      720

aattgcgatc atgctgagga tgctggagtg atttgcttaa atggagcaga cctgaaactg      780

agagtggtag atggactcac tgaatgttca ggaagattgg aagtgaaatt ccaaggagaa      840

tggggaacaa tctgtgatga tggctgggat agtgatgatg ccgctgtggc atgtaagcaa      900

ctgggatgtc caactgctgt cactgccatt ggtcgagtta acgccagtga gggaactgga      960

cacatttggc ttgacagtgt ttcttgccat ggacacgagt ctgctctctg gcagtgtaga     1020

caccatgaat ggggaaagca ttattgcaat cataatgaag atgctggtgt gacatgttct     1080

gatggatcag atctggaact gagacttaaa ggtggaggca gccactgtgc tgggacagtg     1140

gaggtggaaa ttcagaaact ggtaggaaaa gtgtgtgata gaagctgggg actgaaagaa     1200

gctgatgtgg tttgcaggca gctgggatgt ggatctgcac tcaaaacatc atatcaagtt     1260

tattccaaaa ccaaggcaac aaacacatgg ctgtttgtaa gcagctgtaa tggaaatgaa     1320

acttctcttt gggactgcaa gaattggcag tggggtggac ttagttgtga tcactatgac     1380

gaagccaaaa ttacctgctc agcccacagg aaacccaggc tggttggagg ggacattccc     1440

tgctctggtc gtgttgaagt acaacatgga gacacgtggg gcaccgtctg tgattctgac     1500

ttctctctgg aggcggccag cgtgctgtgc agggaactac agtgcggcac tgtggtttcc     1560

ctcctggggg gagctcactt tggagaagga agtggacaga tctgggctga agaattccag     1620

gtgaggggca cgagtcccac ctttcactct gcccagtagc accccgccct gacgggacat     1680

gtagccacag cagggacgtc ggcgtagtct gctcaagata cacacaaatc cgcttggtga     1740

atggcaagac cccatgtgaa ggaagagtgg agctcaacat tcttgggtcc tgggggtccc     1800

tctgcaactc tcactgggac atggaagatg cccatgtttt atgccagcag cttaaatgtg     1860

gagttgccct ttctatcccg ggaggagcac cttttgggaa aggaagtgag caggtctgga     1920

ggcacatgtt tcactgcact gggactgaga agcacatggg agattgttcc gtcactgctc     1980

tgggcgcatc actctgttct tcagggcaag tggcctctgt aatctgctca gggaaccaga     2040

gtcagacact atccccgtgc aattcatcat cctcggaccc atcaagctct attatttcag     2100

aagaaagtgg tgttgcctgc atagggagtg gtcaacttcg cctggtcgat ggaggtggtc     2160

gttgtgctgg gagagtagag gtctatcctg gggcatcctg gggcaccatc tgtgatgaca     2220

gctgggacct gaatgatgcc catgtggtgt gcaaacagct gagctgtgga tgggccatta     2280

atgccactgg ttctgctcat tttggggaag gaacagggcc catttggctg gatgagataa     2340

actgtaatgg aaaagaatct catatttggc aatgccactc acatggttgg gggcggcaca     2400

attgcaggca taaggaggat gcaggagtca tctgctcaga gttcatgtct ctgagactga     2460

tcagtgaaaa cagcagagag acctgtgcag ggcgcctgga agttttttac aacggagctt     2520

ggggcagcgt tggcaggaat agcatgtctc cagccacagt gggggtggta tgcaggcagc     2580

tgggctgtgc agacagaggg gacatcagcc ctgcatcttc agacaagaca gtgtccaggc     2640

acatgtgggt ggacaatgtt cagtgtccta aaggacctga cacactatgg cagtgcccct     2700

catctccatg gaagaagaga ctggccagcc cctcagagga gacatggatc acatgtgcca     2760

acaaaataag acttcaagaa ggaaacacta attgttctgg acgtgtggag atctggtacg     2820

gaggttcctg gggcactgtg tgtgacgact cctgggacct tgaagatgct caggtggtgt     2880

gccgacagct gggctgtggc tcagctttgg aggcaggaaa agagcccgca tttggccagg     2940

ggactgggcc catatggctc aatgaagtga agtgcaaggg gaatgaaccc tccttgtggg     3000

attgtcctgc cagatcctgg ggccacagtg actgtggaca caaggaggat gctgctgtga     3060

cgtgctcaga aattgcaaag agccgagaat ccctacatgc cacaggtcgc tcatcttttg     3120

ttgcacttgc aatctttggg gtcattctgt tggcctgtct catcgcattc ctcatttgga     3180

ctcagaagcg aagacagagg cagcggctct cagttttctc aggaggagag aattctgtcc     3240

atcaaattca ataccgggag atgaattctt gcctgaaagc agatgaaacg gatatgctaa     3300

atccctcagg agaccactct gaagtacaat gaaaaggaaa atgggaatta taacctggtg     3360

agttcagcct ttaagatacc ttgatgaaga cctggacta                            3399


<210>  3
<211>  101
<212>  PRT
<213>  Sus scrofa

<400>  3

Pro Arg Leu Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val 
1               5                   10                  15      


Gln His Gly Asp Thr Trp Gly Thr Val Cys Asp Ser Asp Phe Ser Leu 
            20                  25                  30          


Glu Ala Ala Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val 
        35                  40                  45              


Ser Leu Leu Gly Gly Ala His Phe Gly Glu Gly Ser Gly Gln Ile Trp 
    50                  55                  60                  


Ala Glu Glu Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys 
65                  70                  75                  80  


Pro Val Ala Pro Arg Pro Asp Gly Thr Cys Ser His Ser Arg Asp Val 
                85                  90                  95      


Gly Val Val Cys Ser 
            100     


<210>  4
<211>  51
<212>  DNA
<213>  Sus scrofa

<400>  4
tccctcaccg aaatgctatt ttcagcccac aggaaaccca ggctggttgg a                51


<210>  5
<211>  52
<212>  DNA
<213>  Sus scrofa

<400>  5
tcggcgtagt ctgctcaagt gagacccagg gaatgtgttc actttgttcc ca               52


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for detecting editing events (forward)

<400>  6
aaaccaagag gcatgaatgg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to detect editing events (reverse)

<400>  7
tgtcccagtg agagttgcag                                                   20


<210>  8
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1-FW Primer

<400>  8
acgaattcca gaatggtgct acatgaaaac tctgg                                  35


<210>  9
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D5-FW Primer

<400>  9
tcgatatcac acaggaaacc caggctggtt ggagg                                  35


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D4-RV Primer

<400>  10
gccgatatcg ctgagcaggt aattttggct tcgtc                                  35


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D5-RV Primer

<400>  11
taaccatggt gtatcttgag cagactacgc cgacg                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D9-RV Primer

<400>  12
ccgatatcga gcacgtcaca gcagcatcct ccttg                                  35


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Peptide

<400>  13

Gly Ser Gly Ser Ser Arg Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Lys Leu 
            20      


<210>  14
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2-D55-FC construct

<400>  14
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atatccagga aacccaggct ggttggaggg gacattccct gctctggtcg tgttgaagta      120

caacatggag acacgtgggg caccgtctgt gattctgact tctctctgga ggcggccagc      180

gtgctgtgca gggaactaca gtgcggcact gtggtttccc tcctgggggg agctcacttt      240

ggagaaggaa gtggacagat ctgggctgaa gaattccagt gtgaggggca cgagtcccac      300

ctttcactct gcccagtagc accccgccct gacgggacat gtagccacag cagggacgtc      360

ggcgtagtct gctcaagata caccatggtt agatctccta catgccctac atgtcacaaa      420

tgcccagttc ctgaactctt gggtggacca tctgtcttca tcttcccgcc aaagcccaag      480

gacatcctct tgatctccca gaacgccaag gtcacgtgtg tggtggtgga tgtgagcgag      540

gaggagccgg acgtccagtt cagctggttt gtgaacaacg tagaagtaca cacagctcag      600

acacaacccc gtgaggagca gtacaacagc accttcagag tggtcagtgc cctccccatc      660

cagcaccagg actggatgag cggcaaggag ttcaaatgca aggtcaacaa caaagccctc      720

ccaagcccca tcgagaaaac catctcaaaa cccaaagggc tagtcagaaa accacaggta      780

tacgtcatgg gtccaccgac agagcagttg actgagcaaa cggtcagttt gacctgcttg      840

acctcaggct tcctccctaa cgacatcggt gtggagtgga ccagcaacgg gcatatagaa      900

aagaactaca agaacaccga gccagtgatg gactctgacg gttctttctt catgtacagc      960

aagctcaatg tggaaaggag caggtgggat agcagagcgc ccttcgtctg ctccgtggtc     1020

cacgagggtc tgcacaatca ccacgtggag aagagcatct cccggcctcc gggtaaatga     1080


<210>  15
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D55-FC construct

<400>  15
cccaggctgg ttggagggga cattccctgc tctggtcgtg ttgaagtaca acatggagac       60

acgtggggca ccgtctgtga ttctgacttc tctctggagg cggccagcgt gctgtgcagg      120

gaactacagt gcggcactgt ggtttccctc ctggggggag ctcactttgg agaaggaagt      180

ggacagatct gggctgaaga attccagtgt gaggggcacg agtcccacct ttcactctgc      240

ccagtagcac cccgccctga cgggacatgt agccacagca gggacgtcgg cgtagtctgc      300

tcaagataca ccatggttag atctcctaca tgccctacat gtcacaaatg cccagttcct      360

gaactcttgg gtggaccatc tgtcttcatc ttcccgccaa agcccaagga catcctcttg      420

atctcccaga acgccaaggt cacgtgtgtg gtggtggatg tgagcgagga ggagccggac      480

gtccagttca gctggtttgt gaacaacgta gaagtacaca cagctcagac acaaccccgt      540

gaggagcagt acaacagcac cttcagagtg gtcagtgccc tccccatcca gcaccaggac      600

tggatgagcg gcaaggagtt caaatgcaag gtcaacaaca aagccctccc aagccccatc      660

gagaaaacca tctcaaaacc caaagggcta gtcagaaaac cacaggtata cgtcatgggt      720

ccaccgacag agcagttgac tgagcaaacg gtcagtttga cctgcttgac ctcaggcttc      780

ctccctaacg acatcggtgt ggagtggacc agcaacgggc atatagaaaa gaactacaag      840

aacaccgagc cagtgatgga ctctgacggt tctttcttca tgtacagcaa gctcaatgtg      900

gaaaggagca ggtgggatag cagagcgccc ttcgtctgct ccgtggtcca cgagggtctg      960

cacaatcacc acgtggagaa gagcatctcc cggcctccgg gtaaatga                  1008


