                         SEQUENCE LISTING

<110>  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES 
       ALTERNATIVES
 
<120>  USE OF FLECAINIDE AS AN ANTI-CONNEXIN AGENT AND METHOD FOR 
       POTENTIATING THE EFFECTS OF A PSYCHOTROPIC DRUG

<130>  365692 D32623

<150>  EP13306074.9
<151>  2013-07-24

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  205
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx23 (A6NN92)

<400>  1

Met Ser Leu Asn Tyr Ile Lys Asn Phe Tyr Glu Gly Cys Val Lys Pro 
1               5                   10                  15      


Pro Thr Val Ile Gly Gln Phe His Thr Leu Phe Phe Gly Ser Ile Arg 
            20                  25                  30          


Ile Phe Phe Leu Gly Val Leu Gly Phe Ala Val Tyr Gly Asn Glu Ala 
        35                  40                  45              


Leu His Phe Ile Cys Asp Pro Asp Lys Arg Glu Val Asn Leu Phe Cys 
    50                  55                  60                  


Tyr Asn Gln Phe Arg Pro Ile Thr Pro Gln Val Ser Phe Ser Ala Leu 
65                  70                  75                  80  


Gln Leu Val Ile Val Leu Val Pro Gly Ala Leu Phe His Leu Tyr Ala 
                85                  90                  95      


Ala Cys Lys Ser Ile Asn Gln Glu Cys Ile Leu Gln Lys Pro Ile Tyr 
            100                 105                 110         


Thr Ile Ile Tyr Ile Leu Ser Val Leu Leu Arg Ile Ser Leu Ala Ala 
        115                 120                 125             


Ile Ala Phe Trp Leu Gln Ile Tyr Leu Phe Gly Phe Gln Val Lys Ser 
    130                 135                 140                 


Leu Tyr Leu Cys Asp Ala Arg Ser Leu Gly Glu Asn Met Ile Ile Arg 
145                 150                 155                 160 


Cys Met Val Pro Glu His Phe Glu Lys Thr Ile Phe Leu Ile Ala Ile 
                165                 170                 175     


Asn Thr Phe Thr Thr Ile Thr Ile Leu Leu Phe Val Ala Glu Ile Phe 
            180                 185                 190         


Glu Ile Ile Phe Arg Arg Leu Tyr Phe Pro Phe Arg Gln 
        195                 200                 205 


<210>  2
<211>  223
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx25 (NP_940970.1)

<400>  2

Met Ser Trp Met Phe Leu Arg Asp Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Gly Thr Gly Trp Ile Trp Leu Ala Val Val Phe Val Phe Arg 
            20                  25                  30          


Leu Leu Val Tyr Met Val Ala Ala Glu His Val Trp Lys Asp Glu Gln 
        35                  40                  45              


Lys Glu Phe Glu Cys Asn Ser Arg Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Phe Asp Asp Phe Phe Pro Ile Ser Gln Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Met Val Ser Thr Pro Ser Leu Leu Val Val Leu His Val Ala 
                85                  90                  95      


Tyr His Glu Gly Arg Glu Lys Arg His Arg Lys Lys Leu Tyr Val Ser 
            100                 105                 110         


Pro Gly Thr Met Asp Gly Gly Leu Trp Tyr Ala Tyr Leu Ile Ser Leu 
        115                 120                 125             


Ile Val Lys Thr Gly Phe Glu Ile Gly Phe Leu Val Leu Phe Tyr Lys 
    130                 135                 140                 


Leu Tyr Asp Gly Phe Ser Val Pro Tyr Leu Ile Lys Cys Asp Leu Lys 
145                 150                 155                 160 


Pro Cys Pro Asn Thr Val Asp Cys Phe Ile Ser Lys Pro Thr Glu Lys 
                165                 170                 175     


Thr Ile Phe Ile Leu Phe Leu Val Ile Thr Ser Cys Leu Cys Ile Val 
            180                 185                 190         


Leu Asn Phe Ile Glu Leu Ser Phe Leu Val Leu Lys Cys Phe Ile Lys 
        195                 200                 205             


Cys Cys Leu Gln Lys Tyr Leu Lys Lys Pro Gln Val Leu Ser Val 
    210                 215                 220             


<210>  3
<211>  226
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx26 (P29033.3)

<400>  3

Met Asp Trp Gly Thr Leu Gln Thr Ile Leu Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Ile Leu Val Val Ala Ala Lys Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Ala Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Tyr Phe Pro Ile Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Arg Arg His Glu Lys Lys Arg Lys Phe Ile Lys Gly Glu Ile Lys 
            100                 105                 110         


Ser Glu Phe Lys Asp Ile Glu Glu Ile Lys Thr Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Val 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Val Met Tyr Asp Gly 
145                 150                 155                 160 


Phe Ser Met Gln Arg Leu Val Lys Cys Asn Ala Trp Pro Cys Pro Asn 
                165                 170                 175     


Thr Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Val Phe Met Ile Ala Val Ser Gly Ile Cys Ile Leu Leu Asn Val Thr 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Ile Arg Tyr Cys Ser Gly Lys Ser Lys Lys 
    210                 215                 220                 


Pro Val 
225     


<210>  4
<211>  261
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx30 (NP_001103689.1)

<400>  4

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  5
<211>  279
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx30.2 (NP_853516.1)

<400>  5

Met Cys Gly Arg Phe Leu Arg Arg Leu Leu Ala Glu Glu Ser Arg Arg 
1               5                   10                  15      


Ser Thr Pro Val Gly Arg Leu Leu Leu Pro Val Leu Leu Gly Phe Arg 
            20                  25                  30          


Leu Val Leu Leu Ala Ala Ser Gly Pro Gly Val Tyr Gly Asp Glu Gln 
        35                  40                  45              


Ser Glu Phe Val Cys His Thr Gln Gln Pro Gly Cys Lys Ala Ala Cys 
    50                  55                  60                  


Phe Asp Ala Phe His Pro Leu Ser Pro Leu Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Val Ile Leu Val Ala Val Pro Ser Ala Leu Tyr Met Gly Phe Thr Leu 
                85                  90                  95      


Tyr His Val Ile Trp His Trp Glu Leu Ser Gly Lys Gly Lys Glu Glu 
            100                 105                 110         


Glu Thr Leu Ile Gln Gly Arg Glu Gly Asn Thr Asp Val Pro Gly Ala 
        115                 120                 125             


Gly Ser Leu Arg Leu Leu Trp Ala Tyr Val Ala Gln Leu Gly Ala Arg 
    130                 135                 140                 


Leu Val Leu Glu Gly Ala Ala Leu Gly Leu Gln Tyr His Leu Tyr Gly 
145                 150                 155                 160 


Phe Gln Met Pro Ser Ser Phe Ala Cys Arg Arg Glu Pro Cys Leu Gly 
                165                 170                 175     


Ser Ile Thr Cys Asn Leu Ser Arg Pro Ser Glu Lys Thr Ile Phe Leu 
            180                 185                 190         


Lys Thr Met Phe Gly Val Ser Gly Phe Cys Leu Leu Phe Thr Phe Leu 
        195                 200                 205             


Glu Leu Val Leu Leu Gly Leu Gly Arg Trp Trp Arg Thr Trp Lys His 
    210                 215                 220                 


Lys Ser Ser Ser Ser Lys Tyr Phe Leu Thr Ser Glu Ser Thr Arg Arg 
225                 230                 235                 240 


His Lys Lys Ala Thr Asp Ser Leu Pro Val Val Glu Thr Lys Glu Gln 
                245                 250                 255     


Phe Gln Glu Ala Val Pro Gly Arg Ser Leu Ala Gln Glu Lys Gln Arg 
            260                 265                 270         


Pro Val Gly Pro Arg Asp Ala 
        275                 


<210>  6
<211>  266
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx30.3 (NP_694944.1)

<400>  6

Met Asn Trp Ala Phe Leu Gln Gly Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Val Leu Ser Arg Ile Trp Leu Ser Val Val Phe Ile Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Val Val Ala Ala Glu Glu Val Trp Asp Asp Glu Gln 
        35                  40                  45              


Lys Asp Phe Val Cys Asn Thr Lys Gln Pro Gly Cys Pro Asn Val Cys 
    50                  55                  60                  


Tyr Asp Glu Phe Phe Pro Val Ser His Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Thr Cys Pro Ser Leu Leu Val Val Met His Val Ala 
                85                  90                  95      


Tyr Arg Glu Glu Arg Glu Arg Lys His His Leu Lys His Gly Pro Asn 
            100                 105                 110         


Ala Pro Ser Leu Tyr Asp Asn Leu Ser Lys Lys Arg Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Leu Leu Ser Leu Ile Phe Lys Ala Ala Val Asp Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Ile Phe His Arg Leu Tyr Lys Asp Tyr Asp Met Pro Arg 
145                 150                 155                 160 


Val Val Ala Cys Ser Val Glu Pro Cys Pro His Thr Val Asp Cys Tyr 
                165                 170                 175     


Ile Ser Arg Pro Thr Glu Lys Lys Val Phe Thr Tyr Phe Met Val Thr 
            180                 185                 190         


Thr Ala Ala Ile Cys Ile Leu Leu Asn Leu Ser Glu Val Phe Tyr Leu 
        195                 200                 205             


Val Gly Lys Arg Cys Met Glu Ile Phe Gly Pro Arg His Arg Arg Pro 
    210                 215                 220                 


Arg Cys Arg Glu Cys Leu Pro Asp Thr Cys Pro Pro Tyr Val Leu Ser 
225                 230                 235                 240 


Gln Gly Gly His Pro Glu Asp Gly Asn Ser Val Leu Met Lys Ala Gly 
                245                 250                 255     


Ser Ala Pro Val Asp Ala Gly Gly Tyr Pro 
            260                 265     


<210>  7
<211>  270
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx31 (NP_001005752.1)

<400>  7

Met Asp Trp Lys Thr Leu Gln Ala Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Val Val Phe Val Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Val Val Ala Ala Glu Arg Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Lys Gln Pro Gly Cys Thr Asn Val Cys 
    50                  55                  60                  


Tyr Asp Asn Tyr Phe Pro Ile Ser Asn Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Thr Cys Pro Ser Leu Leu Val Ile Leu His Val Ala 
                85                  90                  95      


Tyr Arg Glu Glu Arg Glu Arg Arg His Arg Gln Lys His Gly Asp Gln 
            100                 105                 110         


Cys Ala Lys Leu Tyr Asp Asn Ala Gly Lys Lys His Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Leu Phe Ser Leu Ile Phe Lys Leu Ile Ile Glu Phe Leu 
    130                 135                 140                 


Phe Leu Tyr Leu Leu His Thr Leu Trp His Gly Phe Asn Met Pro Arg 
145                 150                 155                 160 


Leu Val Gln Cys Ala Asn Val Ala Pro Cys Pro Asn Ile Val Asp Cys 
                165                 170                 175     


Tyr Ile Ala Arg Pro Thr Glu Lys Lys Ile Phe Thr Tyr Phe Met Val 
            180                 185                 190         


Gly Ala Ser Ala Val Cys Ile Val Leu Thr Ile Cys Glu Leu Cys Tyr 
        195                 200                 205             


Leu Ile Cys His Arg Val Leu Arg Gly Leu His Lys Asp Lys Pro Arg 
    210                 215                 220                 


Gly Gly Cys Ser Pro Ser Ser Ser Ala Ser Arg Ala Ser Thr Cys Arg 
225                 230                 235                 240 


Cys His His Lys Leu Val Glu Ala Gly Glu Val Asp Pro Asp Pro Gly 
                245                 250                 255     


Asn Asn Lys Leu Gln Ala Ser Ala Pro Asn Leu Thr Pro Ile 
            260                 265                 270 


<210>  8
<211>  273
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx31.1 (NP_005259.1)

<400>  8

Met Asn Trp Ser Ile Phe Glu Gly Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Leu Val Phe Ile Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Leu Val Thr Ala Glu Arg Val Trp Ser Asp Asp His 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Arg Gln Pro Gly Cys Ser Asn Val Cys 
    50                  55                  60                  


Phe Asp Glu Phe Phe Pro Val Ser His Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Thr Cys Pro Ser Leu Leu Val Val Met His Val Ala 
                85                  90                  95      


Tyr Arg Glu Val Gln Glu Lys Arg His Arg Glu Ala His Gly Glu Asn 
            100                 105                 110         


Ser Gly Arg Leu Tyr Leu Asn Pro Gly Lys Lys Arg Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Val Cys Ser Leu Val Phe Lys Ala Ser Val Asp Ile Ala 
    130                 135                 140                 


Phe Leu Tyr Val Phe His Ser Phe Tyr Pro Lys Tyr Ile Leu Pro Pro 
145                 150                 155                 160 


Val Val Lys Cys His Ala Asp Pro Cys Pro Asn Ile Val Asp Cys Phe 
                165                 170                 175     


Ile Ser Lys Pro Ser Glu Lys Asn Ile Phe Thr Leu Phe Met Val Ala 
            180                 185                 190         


Thr Ala Ala Ile Cys Ile Leu Leu Asn Leu Val Glu Leu Ile Tyr Leu 
        195                 200                 205             


Val Ser Lys Arg Cys His Glu Cys Leu Ala Ala Arg Lys Ala Gln Ala 
    210                 215                 220                 


Met Cys Thr Gly His His Pro His Gly Thr Thr Ser Ser Cys Lys Gln 
225                 230                 235                 240 


Asp Asp Leu Leu Ser Gly Asp Leu Ile Phe Leu Gly Ser Asp Ser His 
                245                 250                 255     


Pro Pro Leu Leu Pro Asp Arg Pro Arg Asp His Val Lys Lys Thr Ile 
            260                 265                 270         


Leu 
    


<210>  9
<211>  294
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Cx31.9 (NP_689343.3)

<400>  9

Met Gly Glu Trp Ala Phe Leu Gly Ser Leu Leu Asp Ala Val Gln Leu 
1               5                   10                  15      


Gln Ser Pro Leu Val Gly Arg Leu Trp Leu Val Val Met Leu Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Ala Thr Val Gly Gly Ala Val Phe Glu Asp Glu 
        35                  40                  45              


Gln Glu Glu Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Arg Gln Thr 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Val Ser His Tyr Arg Phe Trp Leu Phe 
65                  70                  75                  80  


His Ile Leu Leu Leu Ser Ala Pro Pro Val Leu Phe Val Val Tyr Ser 
                85                  90                  95      


Met His Arg Ala Gly Lys Glu Ala Gly Gly Ala Glu Ala Ala Ala Gln 
            100                 105                 110         


Cys Ala Pro Gly Leu Pro Glu Ala Gln Cys Ala Pro Cys Ala Leu Arg 
        115                 120                 125             


Ala Arg Arg Ala Arg Arg Cys Tyr Leu Leu Ser Val Ala Leu Arg Leu 
    130                 135                 140                 


Leu Ala Glu Leu Thr Phe Leu Gly Gly Gln Ala Leu Leu Tyr Gly Phe 
145                 150                 155                 160 


Arg Val Ala Pro His Phe Ala Cys Ala Gly Pro Pro Cys Pro His Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Val Leu 
            180                 185                 190         


Phe Tyr Phe Ala Val Gly Leu Leu Ser Ala Leu Leu Ser Val Ala Glu 
        195                 200                 205             


Leu Gly His Leu Leu Trp Lys Gly Arg Pro Arg Ala Gly Glu Arg Asp 
    210                 215                 220                 


Asn Arg Cys Asn Arg Ala His Glu Glu Ala Gln Lys Leu Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Pro Pro Pro Ala Leu Pro Ser Arg Arg Pro Gly 
                245                 250                 255     


Pro Glu Pro Cys Ala Pro Pro Ala Tyr Ala His Pro Ala Pro Ala Ser 
            260                 265                 270         


Leu Arg Glu Cys Gly Ser Gly Arg Gly Lys Ala Ser Pro Ala Thr Gly 
        275                 280                 285             


Arg Arg Asp Leu Ala Ile 
    290                 


<210>  10
<211>  283
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx32 (NP_000157.1)

<400>  10

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
1               5                   10                  15      


Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
        35                  40                  45              


Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
    50                  55                  60                  


Tyr Asp Gln Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
            100                 105                 110         


Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
        115                 120                 125             


Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
    130                 135                 140                 


Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
145                 150                 155                 160 


Ala Met Val Arg Leu Val Lys Cys Asp Val Tyr Pro Cys Pro Asn Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
            180                 185                 190         


Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
        195                 200                 205             


Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
    210                 215                 220                 


Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
225                 230                 235                 240 


Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                245                 250                 255     


Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
            260                 265                 270         


Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
        275                 280             


<210>  11
<211>  321
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx36 (NP_065711.1)

<400>  11

Met Gly Glu Trp Thr Ile Leu Glu Arg Leu Leu Glu Ala Ala Val Gln 
1               5                   10                  15      


Gln His Ser Thr Met Ile Gly Arg Ile Leu Leu Thr Val Val Val Ile 
            20                  25                  30          


Phe Arg Ile Leu Ile Val Ala Ile Val Gly Glu Thr Val Tyr Asp Asp 
        35                  40                  45              


Glu Gln Thr Met Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Asn Gln 
    50                  55                  60                  


Ala Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val 
65                  70                  75                  80  


Phe Gln Ile Ile Met Val Cys Thr Pro Ser Leu Cys Phe Ile Thr Tyr 
                85                  90                  95      


Ser Val His Gln Ser Ala Lys Gln Arg Glu Arg Arg Tyr Ser Thr Val 
            100                 105                 110         


Phe Leu Ala Leu Asp Arg Asp Pro Pro Glu Ser Ile Gly Gly Pro Gly 
        115                 120                 125             


Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Lys Arg Glu Asp Lys Lys 
    130                 135                 140                 


Leu Gln Asn Ala Ile Val Asn Gly Val Leu Gln Asn Thr Glu Asn Thr 
145                 150                 155                 160 


Ser Lys Glu Thr Glu Pro Asp Cys Leu Glu Val Lys Glu Leu Thr Pro 
                165                 170                 175     


His Pro Ser Gly Leu Arg Thr Ala Ser Lys Ser Lys Leu Arg Arg Gln 
            180                 185                 190         


Glu Gly Ile Ser Arg Phe Tyr Ile Ile Gln Val Val Phe Arg Asn Ala 
        195                 200                 205             


Leu Glu Ile Gly Phe Leu Val Gly Gln Tyr Phe Leu Tyr Gly Phe Ser 
    210                 215                 220                 


Val Pro Gly Leu Tyr Glu Cys Asn Arg Tyr Pro Cys Ile Lys Glu Val 
225                 230                 235                 240 


Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Val Phe 
                245                 250                 255     


Met Phe Ala Val Ser Gly Ile Cys Val Val Leu Asn Leu Ala Glu Leu 
            260                 265                 270         


Asn His Leu Gly Trp Arg Lys Ile Lys Leu Ala Val Arg Gly Ala Gln 
        275                 280                 285             


Ala Lys Arg Lys Ser Ile Tyr Glu Ile Arg Asn Lys Asp Leu Pro Arg 
    290                 295                 300                 


Val Ser Val Pro Asn Phe Gly Arg Thr Gln Ser Ser Asp Ser Ala Tyr 
305                 310                 315                 320 


Val 
    


<210>  12
<211>  333
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx37 (NP_002051.2)

<400>  12

Met Gly Asp Trp Gly Phe Leu Glu Lys Leu Leu Asp Gln Val Gln Glu 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Leu Ala Gly Glu Ser Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Glu Cys Asn Thr Ala Gln Pro Gly Cys Thr Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Phe Leu Phe Val Ser Thr Pro Thr Leu Val Tyr Leu Gly His Val 
                85                  90                  95      


Ile Tyr Leu Ser Arg Arg Glu Glu Arg Leu Arg Gln Lys Glu Gly Glu 
            100                 105                 110         


Leu Arg Ala Leu Pro Ala Lys Asp Pro Gln Val Glu Arg Ala Leu Ala 
        115                 120                 125             


Ala Val Glu Arg Gln Met Ala Lys Ile Ser Val Ala Glu Asp Gly Arg 
    130                 135                 140                 


Leu Arg Ile Arg Gly Ala Leu Met Gly Thr Tyr Val Ala Ser Val Leu 
145                 150                 155                 160 


Cys Lys Ser Val Leu Glu Ala Gly Phe Leu Tyr Gly Gln Trp Arg Leu 
                165                 170                 175     


Tyr Gly Trp Thr Met Glu Pro Val Phe Val Cys Gln Arg Ala Pro Cys 
            180                 185                 190         


Pro Tyr Leu Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Gly Leu Ile Ser Leu Val Leu Asn 
    210                 215                 220                 


Leu Leu Glu Leu Val His Leu Leu Cys Arg Cys Leu Ser Arg Gly Met 
225                 230                 235                 240 


Arg Ala Arg Gln Gly Gln Asp Ala Pro Pro Thr Gln Gly Thr Ser Ser 
                245                 250                 255     


Asp Pro Tyr Thr Asp Gln Val Phe Phe Tyr Leu Pro Val Gly Gln Gly 
            260                 265                 270         


Pro Ser Ser Pro Pro Cys Pro Thr Tyr Asn Gly Leu Ser Ser Ser Glu 
        275                 280                 285             


Gln Asn Trp Ala Asn Leu Thr Thr Glu Glu Arg Leu Ala Ser Ser Arg 
    290                 295                 300                 


Pro Pro Leu Phe Leu Asp Pro Pro Pro Gln Asn Gly Gln Lys Pro Pro 
305                 310                 315                 320 


Ser Arg Pro Ser Ser Ser Ala Ser Lys Lys Gln Tyr Val 
                325                 330             


<210>  13
<211>  358
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx40 (NP_005257)

<400>  13

Met Gly Asp Trp Ser Phe Leu Gly Asn Phe Leu Glu Glu Val His Lys 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Thr Ala Ala Glu Ser Ser Trp Gly Asp Glu 
        35                  40                  45              


Gln Ala Asp Phe Arg Cys Asp Thr Ile Gln Pro Gly Cys Gln Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Met His Thr Val Arg Met Gln Glu Lys Arg Lys Leu Arg Glu Ala Glu 
            100                 105                 110         


Arg Ala Lys Glu Val Arg Gly Ser Gly Ser Tyr Glu Tyr Pro Val Ala 
        115                 120                 125             


Glu Lys Ala Glu Leu Ser Cys Trp Glu Glu Gly Asn Gly Arg Ile Ala 
    130                 135                 140                 


Leu Gln Gly Thr Leu Leu Asn Thr Tyr Val Cys Ser Ile Leu Ile Arg 
145                 150                 155                 160 


Thr Thr Met Glu Val Gly Phe Ile Val Gly Gln Tyr Phe Ile Tyr Gly 
                165                 170                 175     


Ile Phe Leu Thr Thr Leu His Val Cys Arg Arg Ser Pro Cys Pro His 
            180                 185                 190         


Pro Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn Val Phe Ile 
        195                 200                 205             


Val Phe Met Leu Ala Val Ala Ala Leu Ser Leu Leu Leu Ser Leu Ala 
    210                 215                 220                 


Glu Leu Tyr His Leu Gly Trp Lys Lys Ile Arg Gln Arg Phe Val Lys 
225                 230                 235                 240 


Pro Arg Gln His Met Ala Lys Cys Gln Leu Ser Gly Pro Ser Val Gly 
                245                 250                 255     


Ile Val Gln Ser Cys Thr Pro Pro Pro Asp Phe Asn Gln Cys Leu Glu 
            260                 265                 270         


Asn Gly Pro Gly Gly Lys Phe Phe Asn Pro Phe Ser Asn Asn Met Ala 
        275                 280                 285             


Ser Gln Gln Asn Thr Asp Asn Leu Val Thr Glu Gln Val Arg Gly Gln 
    290                 295                 300                 


Glu Gln Thr Pro Gly Glu Gly Phe Ile Gln Val Arg Tyr Gly Gln Lys 
305                 310                 315                 320 


Pro Glu Val Pro Asn Gly Val Ser Pro Gly His Arg Leu Pro His Gly 
                325                 330                 335     


Tyr His Ser Asp Lys Arg Arg Leu Ser Lys Ala Ser Ser Lys Ala Arg 
            340                 345                 350         


Ser Asp Asp Leu Ser Val 
        355             


<210>  14
<211>  370
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Cx40.1 (NP_699199.2)

<400>  14

Met Glu Gly Val Asp Leu Leu Gly Phe Leu Ile Ile Thr Leu Asn Cys 
1               5                   10                  15      


Asn Val Thr Met Val Gly Lys Leu Trp Phe Val Leu Thr Met Leu Leu 
            20                  25                  30          


Arg Met Leu Val Ile Val Leu Ala Gly Arg Pro Val Tyr Gln Asp Glu 
        35                  40                  45              


Gln Glu Arg Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Ala Asn Val 
    50                  55                  60                  


Cys Tyr Asp Val Phe Ser Pro Val Ser His Leu Arg Phe Trp Leu Ile 
65                  70                  75                  80  


Gln Gly Val Cys Val Leu Leu Pro Ser Ala Val Phe Ser Val Tyr Val 
                85                  90                  95      


Leu His Arg Gly Ala Thr Leu Ala Ala Leu Gly Pro Arg Arg Cys Pro 
            100                 105                 110         


Asp Pro Arg Glu Pro Ala Ser Gly Gln Arg Arg Cys Pro Arg Pro Phe 
        115                 120                 125             


Gly Glu Arg Gly Gly Leu Gln Val Pro Asp Phe Ser Ala Gly Tyr Ile 
    130                 135                 140                 


Ile His Leu Leu Leu Arg Thr Leu Leu Glu Ala Ala Phe Gly Ala Leu 
145                 150                 155                 160 


His Tyr Phe Leu Phe Gly Phe Leu Ala Pro Lys Lys Phe Pro Cys Thr 
                165                 170                 175     


Arg Pro Pro Cys Thr Gly Val Val Asp Cys Tyr Val Ser Arg Pro Thr 
            180                 185                 190         


Glu Lys Ser Leu Leu Met Leu Phe Leu Trp Ala Val Ser Ala Leu Ser 
        195                 200                 205             


Phe Leu Leu Gly Leu Ala Asp Leu Val Cys Ser Leu Arg Arg Arg Met 
    210                 215                 220                 


Arg Arg Arg Pro Gly Pro Pro Thr Ser Pro Ser Ile Arg Lys Gln Ser 
225                 230                 235                 240 


Gly Ala Ser Gly His Ala Glu Gly Arg Arg Thr Asp Glu Glu Gly Gly 
                245                 250                 255     


Arg Glu Glu Glu Gly Ala Pro Ala Pro Pro Gly Ala Arg Ala Gly Gly 
            260                 265                 270         


Glu Gly Ala Gly Ser Pro Arg Arg Thr Ser Arg Val Ser Gly His Thr 
        275                 280                 285             


Lys Ile Pro Asp Glu Asp Glu Ser Glu Val Thr Ser Ser Ala Ser Glu 
    290                 295                 300                 


Lys Leu Gly Arg Gln Pro Arg Gly Arg Pro His Arg Glu Ala Ala Gln 
305                 310                 315                 320 


Asp Pro Arg Gly Ser Gly Ser Glu Glu Gln Pro Ser Ala Ala Pro Ser 
                325                 330                 335     


Arg Leu Ala Ala Pro Pro Ser Cys Ser Ser Leu Gln Pro Pro Asp Pro 
            340                 345                 350         


Pro Ala Ser Ser Ser Gly Ala Pro His Leu Arg Ala Arg Lys Ser Glu 
        355                 360                 365             


Trp Val 
    370 


<210>  15
<211>  382
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx43 (NP_000156.1)

<400>  15

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  16
<211>  396
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx45 (NP_001073852.1)

<400>  16

Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile His Asn His 
1               5                   10                  15      


Ser Thr Phe Val Gly Lys Ile Trp Leu Thr Val Leu Ile Val Phe Arg 
            20                  25                  30          


Ile Val Leu Thr Ala Val Gly Gly Glu Ser Ile Tyr Tyr Asp Glu Gln 
        35                  40                  45              


Ser Lys Phe Val Cys Asn Thr Glu Gln Pro Gly Cys Glu Asn Val Cys 
    50                  55                  60                  


Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Ile Ile Leu Val Ala Thr Pro Ser Val Met Tyr Leu Gly Tyr Ala Ile 
                85                  90                  95      


His Lys Ile Ala Lys Met Glu His Gly Glu Ala Asp Lys Lys Ala Ala 
            100                 105                 110         


Arg Ser Lys Pro Tyr Ala Met Arg Trp Lys Gln His Arg Ala Leu Glu 
        115                 120                 125             


Glu Thr Glu Glu Asp Asn Glu Glu Asp Pro Met Met Tyr Pro Glu Met 
    130                 135                 140                 


Glu Leu Glu Ser Asp Lys Glu Asn Lys Glu Gln Ser Gln Pro Lys Pro 
145                 150                 155                 160 


Lys His Asp Gly Arg Arg Arg Ile Arg Glu Asp Gly Leu Met Lys Ile 
                165                 170                 175     


Tyr Val Leu Gln Leu Leu Ala Arg Thr Val Phe Glu Val Gly Phe Leu 
            180                 185                 190         


Ile Gly Gln Tyr Phe Leu Tyr Gly Phe Gln Val His Pro Phe Tyr Val 
        195                 200                 205             


Cys Ser Arg Leu Pro Cys Pro His Lys Ile Asp Cys Phe Ile Ser Arg 
    210                 215                 220                 


Pro Thr Glu Lys Thr Ile Phe Leu Leu Ile Met Tyr Gly Val Thr Gly 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Asn Ile Trp Glu Met Leu His Leu Gly Phe Gly 
                245                 250                 255     


Thr Ile Arg Asp Ser Leu Asn Ser Lys Arg Arg Glu Leu Glu Asp Pro 
            260                 265                 270         


Gly Ala Tyr Asn Tyr Pro Phe Thr Trp Asn Thr Pro Ser Ala Pro Pro 
        275                 280                 285             


Gly Tyr Asn Ile Ala Val Lys Pro Asp Gln Ile Gln Tyr Thr Glu Leu 
    290                 295                 300                 


Ser Asn Ala Lys Ile Ala Tyr Lys Gln Asn Lys Ala Asn Thr Ala Gln 
305                 310                 315                 320 


Glu Gln Gln Tyr Gly Ser His Glu Glu Asn Leu Pro Ala Asp Leu Glu 
                325                 330                 335     


Ala Leu Gln Arg Glu Ile Arg Met Ala Gln Glu Arg Leu Asp Leu Ala 
            340                 345                 350         


Val Gln Ala Tyr Ser His Gln Asn Asn Pro His Gly Pro Arg Glu Lys 
        355                 360                 365             


Lys Ala Lys Val Gly Ser Lys Ala Gly Ser Asn Lys Ser Thr Ala Ser 
    370                 375                 380                 


Ser Lys Ser Gly Asp Gly Lys Thr Ser Val Trp Ile 
385                 390                 395     


<210>  17
<211>  435
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx46 (NP_068773.2)

<400>  17

Met Gly Asp Trp Ser Phe Leu Gly Arg Leu Leu Glu Asn Ala Gln Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Gly Ala Ala Ala Glu Asp Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Thr Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Phe Trp Ala Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Thr Leu Ile Tyr Leu Gly His Val 
                85                  90                  95      


Leu His Ile Val Arg Met Glu Glu Lys Lys Lys Glu Arg Glu Glu Glu 
            100                 105                 110         


Glu Gln Leu Lys Arg Glu Ser Pro Ser Pro Lys Glu Pro Pro Gln Asp 
        115                 120                 125             


Asn Pro Ser Ser Arg Asp Asp Arg Gly Arg Val Arg Met Ala Gly Ala 
    130                 135                 140                 


Leu Leu Arg Thr Tyr Val Phe Asn Ile Ile Phe Lys Thr Leu Phe Glu 
145                 150                 155                 160 


Val Gly Phe Ile Ala Gly Gln Tyr Phe Leu Tyr Gly Phe Glu Leu Lys 
                165                 170                 175     


Pro Leu Tyr Arg Cys Asp Arg Trp Pro Cys Pro Asn Thr Val Asp Cys 
            180                 185                 190         


Phe Ile Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Ile Phe Met Leu 
        195                 200                 205             


Ala Val Ala Cys Ala Ser Leu Leu Leu Asn Met Leu Glu Ile Tyr His 
    210                 215                 220                 


Leu Gly Trp Lys Lys Leu Lys Gln Gly Val Thr Ser Arg Leu Gly Pro 
225                 230                 235                 240 


Asp Ala Ser Glu Ala Pro Leu Gly Thr Ala Asp Pro Pro Pro Leu Pro 
                245                 250                 255     


Pro Ser Ser Arg Pro Pro Ala Val Ala Ile Gly Phe Pro Pro Tyr Tyr 
            260                 265                 270         


Ala His Thr Ala Ala Pro Leu Gly Gln Ala Arg Ala Val Gly Tyr Pro 
        275                 280                 285             


Gly Ala Pro Pro Pro Ala Ala Asp Phe Lys Leu Leu Ala Leu Thr Glu 
    290                 295                 300                 


Ala Arg Gly Lys Gly Gln Ser Ala Lys Leu Tyr Asn Gly His His His 
305                 310                 315                 320 


Leu Leu Met Thr Glu Gln Asn Trp Ala Asn Gln Ala Ala Glu Arg Gln 
                325                 330                 335     


Pro Pro Ala Leu Lys Ala Tyr Pro Ala Ala Ser Thr Pro Ala Ala Pro 
            340                 345                 350         


Ser Pro Val Gly Ser Ser Ser Pro Pro Leu Ala His Glu Ala Glu Ala 
        355                 360                 365             


Gly Ala Ala Pro Leu Leu Leu Asp Gly Ser Gly Ser Ser Leu Glu Gly 
    370                 375                 380                 


Ser Ala Leu Ala Gly Thr Pro Glu Glu Glu Glu Gln Ala Val Thr Thr 
385                 390                 395                 400 


Ala Ala Gln Met His Gln Pro Pro Leu Pro Leu Gly Asp Pro Gly Arg 
                405                 410                 415     


Ala Ser Lys Ala Ser Arg Ala Ser Ser Gly Arg Ala Arg Pro Glu Asp 
            420                 425                 430         


Leu Ala Ile 
        435 


<210>  18
<211>  439
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx47 (NP_065168.2)

<400>  18

Met Thr Asn Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile 
1               5                   10                  15      


His Asn His Ser Thr Phe Val Gly Lys Val Trp Leu Thr Val Leu Val 
            20                  25                  30          


Val Phe Arg Ile Val Leu Thr Ala Val Gly Gly Glu Ala Ile Tyr Ser 
        35                  40                  45              


Asp Glu Gln Ala Lys Phe Thr Cys Asn Thr Arg Gln Pro Gly Cys Asp 
    50                  55                  60                  


Asn Val Cys Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp 
65                  70                  75                  80  


Val Phe Gln Ile Val Val Ile Ser Thr Pro Ser Val Met Tyr Leu Gly 
                85                  90                  95      


Tyr Ala Val His Arg Leu Ala Arg Ala Ser Glu Gln Glu Arg Arg Arg 
            100                 105                 110         


Ala Leu Arg Arg Arg Pro Gly Pro Arg Arg Ala Pro Arg Ala His Leu 
        115                 120                 125             


Pro Pro Pro His Ala Gly Trp Pro Glu Pro Ala Asp Leu Gly Glu Glu 
    130                 135                 140                 


Glu Pro Met Leu Gly Leu Gly Glu Glu Glu Glu Glu Glu Glu Thr Gly 
145                 150                 155                 160 


Ala Ala Glu Gly Ala Gly Glu Glu Ala Glu Glu Ala Gly Ala Glu Glu 
                165                 170                 175     


Ala Cys Thr Lys Ala Val Gly Ala Asp Gly Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Gly Pro Thr Gly Gln His Asp Gly Arg Arg Arg Ile Gln Arg Glu Gly 
        195                 200                 205             


Leu Met Arg Val Tyr Val Ala Gln Leu Val Ala Arg Ala Ala Phe Glu 
    210                 215                 220                 


Val Ala Phe Leu Val Gly Gln Tyr Leu Leu Tyr Gly Phe Glu Val Arg 
225                 230                 235                 240 


Pro Phe Phe Pro Cys Ser Arg Gln Pro Cys Pro His Val Val Asp Cys 
                245                 250                 255     


Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Leu Val Met Tyr 
            260                 265                 270         


Val Val Ser Cys Leu Cys Leu Leu Leu Asn Leu Cys Glu Met Ala His 
        275                 280                 285             


Leu Gly Leu Gly Ser Ala Gln Asp Ala Val Arg Gly Arg Arg Gly Pro 
    290                 295                 300                 


Pro Ala Ser Ala Pro Ala Pro Ala Pro Arg Pro Pro Pro Cys Ala Phe 
305                 310                 315                 320 


Pro Ala Ala Ala Ala Gly Leu Ala Cys Pro Pro Asp Tyr Ser Leu Val 
                325                 330                 335     


Val Arg Ala Ala Glu Arg Ala Arg Ala His Asp Gln Asn Leu Ala Asn 
            340                 345                 350         


Leu Ala Leu Gln Ala Leu Arg Asp Gly Ala Ala Ala Gly Asp Arg Asp 
        355                 360                 365             


Arg Asp Ser Ser Pro Cys Val Gly Leu Pro Ala Ala Ser Arg Gly Pro 
    370                 375                 380                 


Pro Arg Ala Gly Ala Pro Ala Ser Arg Thr Gly Ser Ala Thr Ser Ala 
385                 390                 395                 400 


Gly Thr Val Gly Glu Gln Gly Arg Pro Gly Thr His Glu Arg Pro Gly 
                405                 410                 415     


Ala Lys Pro Arg Ala Gly Ser Glu Lys Gly Ser Ala Ser Ser Arg Asp 
            420                 425                 430         


Gly Lys Thr Thr Val Trp Ile 
        435                 


<210>  19
<211>  433
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx50 (NP_005258.2)

<400>  19

Met Gly Asp Trp Ser Phe Leu Gly Asn Ile Leu Glu Glu Val Asn Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Arg Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Thr Ala Ala Glu Phe Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Val Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Glu Ala Phe Pro Ile Ser His Ile Arg Leu Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Met Tyr Val Gly His Ala 
                85                  90                  95      


Val His Tyr Val Arg Met Glu Glu Lys Arg Lys Ser Arg Glu Ala Glu 
            100                 105                 110         


Glu Leu Gly Gln Gln Ala Gly Thr Asn Gly Gly Pro Asp Gln Gly Ser 
        115                 120                 125             


Val Lys Lys Ser Ser Gly Ser Lys Gly Thr Lys Lys Phe Arg Leu Glu 
    130                 135                 140                 


Gly Thr Leu Leu Arg Thr Tyr Ile Cys His Ile Ile Phe Lys Thr Leu 
145                 150                 155                 160 


Phe Glu Val Gly Phe Ile Val Gly His Tyr Phe Leu Tyr Gly Phe Arg 
                165                 170                 175     


Ile Leu Pro Leu Tyr Arg Cys Ser Arg Trp Pro Cys Pro Asn Val Val 
            180                 185                 190         


Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Leu Phe 
        195                 200                 205             


Met Leu Ser Val Ala Ser Val Ser Leu Phe Leu Asn Val Met Glu Leu 
    210                 215                 220                 


Gly His Leu Gly Leu Lys Gly Ile Arg Ser Ala Leu Lys Arg Pro Val 
225                 230                 235                 240 


Glu Gln Pro Leu Gly Glu Ile Pro Glu Lys Ser Leu His Ser Ile Ala 
                245                 250                 255     


Val Ser Ser Ile Gln Lys Ala Lys Gly Tyr Gln Leu Leu Glu Glu Glu 
            260                 265                 270         


Lys Ile Val Ser His Tyr Phe Pro Leu Thr Glu Val Gly Met Val Glu 
        275                 280                 285             


Thr Ser Pro Leu Pro Ala Lys Pro Phe Asn Gln Phe Glu Glu Lys Ile 
    290                 295                 300                 


Ser Thr Gly Pro Leu Gly Asp Leu Ser Arg Gly Tyr Gln Glu Thr Leu 
305                 310                 315                 320 


Pro Ser Tyr Ala Gln Val Gly Ala Gln Glu Val Glu Gly Glu Gly Pro 
                325                 330                 335     


Pro Ala Glu Glu Gly Ala Glu Pro Glu Val Gly Glu Lys Lys Glu Glu 
            340                 345                 350         


Ala Glu Arg Leu Thr Thr Glu Glu Gln Glu Lys Val Ala Val Pro Glu 
        355                 360                 365             


Gly Glu Lys Val Glu Thr Pro Gly Val Asp Lys Glu Gly Glu Lys Glu 
    370                 375                 380                 


Glu Pro Gln Ser Glu Lys Val Ser Lys Gln Gly Leu Pro Ala Glu Lys 
385                 390                 395                 400 


Thr Pro Ser Leu Cys Pro Glu Leu Thr Thr Asp Asp Ala Arg Pro Leu 
                405                 410                 415     


Ser Arg Leu Ser Lys Ala Ser Ser Arg Ala Arg Ser Asp Asp Leu Thr 
            420                 425                 430         


Val 
    


<210>  20
<211>  515
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx59 (NP_110399.2)

<400>  20

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Gly Asn Leu Lys Gly Gln Phe Arg 
        435                 440                 445             


Lys Gly Thr Val Arg Thr Leu Pro Pro Ser Gln Gly Asp Ser Gln Ser 
    450                 455                 460                 


Leu Asp Ile Pro Asn Thr Ala Asp Ser Leu Gly Gly Leu Ser Phe Glu 
465                 470                 475                 480 


Pro Gly Leu Val Arg Thr Cys Asn Asn Pro Val Cys Pro Pro Asn His 
                485                 490                 495     


Val Val Ser Leu Thr Asn Asn Leu Ile Gly Arg Arg Val Pro Thr Asp 
            500                 505                 510         


Leu Gln Ile 
        515 


<210>  21
<211>  543
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cx62 (NP_115991.1)

<400>  21

Met Gly Asp Trp Asn Leu Leu Gly Gly Ile Leu Glu Glu Val His Ser 
1               5                   10                  15      


His Ser Thr Ile Val Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Arg Val Ala Ala Glu Asp Val Trp Asp Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Ala Cys Asn Thr Arg Gln Pro Gly Cys Asn Asn Ile 
    50                  55                  60                  


Cys Tyr Asp Asp Ala Phe Pro Ile Ser Leu Ile Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Ala Phe Glu Lys Asp Arg Gln Arg Lys Lys Ser 
            100                 105                 110         


His Leu Arg Ala Gln Met Glu Asn Pro Asp Leu Asp Leu Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Asp Arg Glu Leu Arg Arg Leu Glu Glu Gln Lys Arg Ile 
    130                 135                 140                 


His Lys Val Pro Leu Lys Gly Cys Leu Leu Arg Thr Tyr Val Leu His 
145                 150                 155                 160 


Ile Leu Thr Arg Ser Val Leu Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Ile Leu Tyr Gly Phe Gln Met His Pro Leu Tyr Lys Cys Thr Gln Pro 
            180                 185                 190         


Pro Cys Pro Asn Ala Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Met Leu Phe Met His Ser Ile Ala Ala Ile Ser Leu Leu 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Ile Arg Lys Ile Met Arg 
225                 230                 235                 240 


Thr Leu Tyr Lys Lys Ser Ser Ser Glu Gly Ile Glu Asp Glu Thr Gly 
                245                 250                 255     


Pro Pro Phe His Leu Lys Lys Tyr Ser Val Ala Gln Gln Cys Met Ile 
            260                 265                 270         


Cys Ser Ser Leu Pro Glu Arg Ile Ser Pro Leu Gln Ala Asn Asn Gln 
        275                 280                 285             


Gln Gln Val Ile Arg Val Asn Val Pro Lys Ser Lys Thr Met Trp Gln 
    290                 295                 300                 


Ile Pro Gln Pro Arg Gln Leu Glu Val Asp Pro Ser Asn Gly Lys Lys 
305                 310                 315                 320 


Asp Trp Ser Glu Lys Asp Gln His Ser Gly Gln Leu His Val His Ser 
                325                 330                 335     


Pro Cys Pro Trp Ala Gly Ser Ala Gly Asn Gln His Leu Gly Gln Gln 
            340                 345                 350         


Ser Asp His Ser Ser Phe Gly Leu Gln Asn Thr Met Ser Gln Ser Trp 
        355                 360                 365             


Leu Gly Thr Thr Thr Ala Pro Arg Asn Cys Pro Ser Phe Ala Val Gly 
    370                 375                 380                 


Thr Trp Glu Gln Ser Gln Asp Pro Glu Pro Ser Gly Glu Pro Leu Thr 
385                 390                 395                 400 


Asp Leu His Ser His Cys Arg Asp Ser Glu Gly Ser Met Arg Glu Ser 
                405                 410                 415     


Gly Val Trp Ile Asp Arg Ser Arg Pro Gly Ser Arg Lys Ala Ser Phe 
            420                 425                 430         


Leu Ser Arg Leu Leu Ser Glu Lys Arg His Leu His Ser Asp Ser Gly 
        435                 440                 445             


Ser Ser Gly Ser Arg Asn Ser Ser Cys Leu Asp Phe Pro His Trp Glu 
    450                 455                 460                 


Asn Ser Pro Ser Pro Leu Pro Ser Val Thr Gly His Arg Thr Ser Met 
465                 470                 475                 480 


Val Arg Gln Ala Ala Leu Pro Ile Met Glu Leu Ser Gln Glu Leu Phe 
                485                 490                 495     


His Ser Gly Cys Phe Leu Phe Pro Phe Phe Leu Pro Gly Val Cys Met 
            500                 505                 510         


Tyr Val Cys Val Asp Arg Glu Ala Asp Gly Gly Gly Asp Tyr Leu Trp 
        515                 520                 525             


Arg Asp Lys Ile Ile His Ser Ile His Ser Val Lys Phe Asn Ser 
    530                 535                 540             


