                         SEQUENCE LISTING

<110>  NOVO NORDISK A/S
 
<120>  PHARMACEUTICAL COMPOSITION FOR ORAL INSULIN ADMINISTRATION 
       COMPRISING A TABLET CORE AND AN ANIONIC COPOLYMER COATING

<130>  8707WO01

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Modified Insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Gly is absent or Gly

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Pro is absent or Pro

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Pro is absent or Pro

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Thr is Thr or His

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Ser is Ser, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Leu is Leu, Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser or 
       Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Tyr is Tyr, Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser or 
       Glu

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Gln is Gln, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Asn is Asn, Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Asn is Asn or Gln

<400>  1

Gly Pro Pro Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
1               5                   10                  15      


Tyr Asp Leu Glu Asp Tyr Cys Asn 
            20                  


<210>  2
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Modified Insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Gly is absent or Gly

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Pro is absent or Pro

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Pro is absent or Pro

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Glu is absent Phe or Glu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Val is absent or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Asn is absent, Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Gln is Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  His is His, Asp, Pro or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Tyr is Tyr, Asp, Gln, His, Arg or Glu

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Phe is Phe or His

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Phe is Phe, Asn or His

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Tyr is absent, Tyr, His, Thr, Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Thr is absent, Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser 
       or Glu

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Pro is absent, Pro, His, Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Lys is absent, Lys, Arg or Gln

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Thr is absent or Thr

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Leu is absent or Leu

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Glu is absent or Glu

<400>  2

Gly Pro Pro Phe Val Asp Gln His Leu Cys Gly Ser His Leu Val Glu 
1               5                   10                  15      


Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Tyr 
            20                  25                  30          


Thr Leu Glu 
        35  


<210>  3
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Modified insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Thr is Thr or His

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Ser is Ser, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Leu is Leu, Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser or 
       Glu

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Thr is Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Gln is Gln, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Asn is Asn, Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Asn is Asn or Gln

<400>  3

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Thr Asp Leu 
1               5                   10                  15      


Glu Gln Tyr Cys Asn 
            20      


<210>  4
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Modified insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Glu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Asn is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Gln is Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  His is His, Asp, Pro or Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Tyr is Tyr, Asp, Gln, His, Arg or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Phe is Phe or His

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Tyr is absent, Tyr, His, Thr, Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Thr is absent, Thr, Asn, Asp, Gln, His, Lys, Gly, Arg, Pro, Ser 
       or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Pro is absent, Pro, His, Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Lys is absent, Lys, Arg or Gln

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Thr is absent or Thr

<400>  4

Phe Val Asn Glu His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Tyr Thr 
            20                  25                  30  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Modified A chain


<220>
<221>  DISULFID
<222>  (6)..(6)

<220>
<221>  DISULFID
<222>  (7)..(7)

<220>
<221>  DISULFID
<222>  (10)..(10)

<220>
<221>  DISULFID
<222>  (11)..(11)

<220>
<221>  DISULFID
<222>  (20)..(20)

<400>  5

Gly Ile Val Glu Gln Cys Cys Thr Ser Cys Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  6
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Modified B chain


<220>
<221>  DISULFID
<222>  (4)..(4)

<220>
<221>  DISULFID
<222>  (7)..(7)

<220>
<221>  DISULFID
<222>  (19)..(19)

<220>
<221>  Lys
<222>  (29)..(29)
<223>  Lys is Lys-(N(epsilon)-Octadecanedioyl-gGlu-OEG-OEG)

<400>  6

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  


