                         SEQUENCE LISTING

<110>  University of Rochester
       Cox, Andrew
       Dewhurst, Stephen
       Treanor, John
       Baek, Kim
 
<120>  ATTENUATED INFLUENZA VACCINES AND USES THEREOF

<130>  87550-911304 (088WO1)

<150>  US 60/856,442
<151>  2013-07-19

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala Met Ile Thr Tyr Ile 
1               5                   10                  15      


<210>  2
<211>  757
<212>  PRT
<213>  Influenza A virus

<400>  2

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala His 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Ile Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Ile Glu Ser Met Asp Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Lys Ser Lys Ser Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 


Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 


Val Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Leu Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Ala Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  3
<211>  757
<212>  PRT
<213>  Influenza A virus

<400>  3

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Ile Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asn Lys 
                165                 170                 175     


Glu Glu Ile Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Lys Arg Gly Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Ile Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     


Leu Ser Met Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Arg Met Lys Ile Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 


Thr Lys Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         


Lys Thr Ile Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Lys Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Val Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Asp Gln Thr Gln Ser Lys Val Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Asp Asp Tyr Arg Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Asp Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Val Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Ser Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  4
<211>  757
<212>  PRT
<213>  Influenza A virus

<400>  4

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Arg Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Ala Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Val Asn Lys Arg Gly Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Lys Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Lys Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 


Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Lys Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Ile 
                565                 570                 575     


Lys Lys Leu Trp Asp Gln Thr Gln Ser Arg Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asn Tyr Arg Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Ile Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Ser Glu Ile Met Arg Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  5
<211>  744
<212>  PRT
<213>  Influenza A virus

<400>  5

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Arg Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Leu Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Lys Leu Thr Lys Lys Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val His Phe Val Glu 
                245                 250                 255     


Ala Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Val Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Asn Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 


Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Glu Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Arg Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Gly Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Val Glu Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Thr Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Met Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Ala Glu Ile Leu 
            740                 


<210>  6
<211>  2274
<212>  DNA
<213>  Influenza A virus

<400>  6
atggatgtca atccgacctt acttttcttg aaagttccag cgcaaaatgc cataagtact       60

acattccctt atactggaga tcctccatac agccatggaa caggaacagg atacaccatg      120

gacacagtca acagaacaca tcaatattca gaaaagggga agtggacaac aaacacggaa      180

actggagcgc accaacttaa cccaattgat ggaccactac ctgaggacaa tgaaccaagt      240

ggatatgcac aaacagactg cgtcctggaa gcaatggctt tccttgaaga atcccaccca      300

ggaatctttg aaaactcgtg tcttgaaacg atggaagtta ttcaacaaac aagagtggac      360

aaactgaccc aaggtcgtca gacctatgat tggacattga acagaaatca gccggctgca      420

actgcgctag ccaacactat agaggtcttc agatcgaatg gcctgacagc taatgaatcg      480

ggaaggctaa tagatttcct caaggatgtg atagaatcaa tggataaaga ggagatggaa      540

atcacaacac acttccaaag aaaaagaaga gtaagagaca acatgaccaa gaaaatggtc      600

acacaacgaa caataggaaa gaagaagcaa agattgaaca agagaagcta tctaataaga      660

gcactgacat tgaacacaat gactaaagat gcagagagag gtaaattaaa gagaagagca      720

attgcaacac ccggtatgca gatcagaggg ttcgtgtact ttgtcgaaac actagcgaga      780

agtatttgtg agaagcttga acagtctggg cttccggttg gaggtaatga aaagaaggct      840

aaactggcaa atgttgtgcg aaaaatgatg actaattcac aagacacaga gctctctttc      900

acaattactg gagacaatac caaatggaat gagaatcaaa atcctcggat gttcctggcg      960

atgataacat acatcacaag aaatcaacct gaatggttta gaaacgtcct gagcatcgca     1020

cctataatgt tctcaaataa aatggcaaga ctagggaaag gatacatgtt caaaagcaag     1080

agcatgaagc tccgaacaca aataccagca gaaatgctag caagtattga cctgaaatac     1140

tttaatgaat caacaagaaa gaaaatcgag aaaataaggc ctctcctaat agatggcaca     1200

gtctcattga gtcctggaat gatgatgggc atgttcaaca tgctaagtac agtcttagga     1260

gtctcaatcc tgaatcttgg acaaaagaag tacaccaaaa caacatactg gtgggacgga     1320

ctccaatcct ctgatgactt cgccctcata gtgaatgcac caaatcatga gggaatacaa     1380

gcaggggtgg atagattcta cagaacctgc aagctagtcg gaatcaatat gagcaaaaag     1440

aagtcctaca taaataggac agggacattt gaattcacaa gctttttcta tcgctatgga     1500

tttgtagcca attttagcat ggagctgccc agctttggag tgtctggaat taatgaatcg     1560

gctgatatga gcattggggt aacagtgata aagaacaaca tgataaacaa tgaccttggg     1620

ccagcaacag cccaactggc tcttcaacta ttcatcaaag actacagata tacgtaccgg     1680

tgccacagag gagacacaca aattcagaca aggagatcat tcgagctaaa gaagctgtgg     1740

gagcaaaccc gctcaaaggc aggacttttg gtttcggatg gaggaccaaa cttatacaat     1800

atccggaatc tccacattcc agaagtctgc ttgaagtggg agctaatgga tgaagactat     1860

caggggaggc tttgtaatcc cctgaatcca tttgtcagtc ataaggagat tgagtctgta     1920

aacaatgctg tggtaatgcc agctcacggt ccagccaaga gcatggaata tgatgctgtt     1980

gctactacac actcctggat ccctaagagg aaccgctcca ttctcaacac aagccaaagg     2040

ggaattcttg aagatgaaca gatgtatcag aagtgttgca atctattcga gaaattcttc     2100

cctagcagtt cgtacaggag accagttgga atttccagca tggtggaggc catggtgtct     2160

agggcccgga ttgatgcacg gattgacttc gagtctggac ggattaagaa agaggagttc     2220

gctgagatca tgaagatctg ttccaccatt gaagagctca gacggcaaaa atag           2274


<210>  7
<211>  759
<212>  PRT
<213>  Influenza A virus

<400>  7

Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ser Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Met Ser Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Met Thr Ser Thr Val His Tyr Pro 
            100                 105                 110         


Lys Ile Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Thr Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Glu Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Lys 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Ile Glu His Ile Asp Asn Val Met Gly Met Ile Gly Val Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Thr Glu Met Ser Met Arg Gly Val Arg Val 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Ala Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Thr Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Leu Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Ile Phe 
                645                 650                 655     


Asn Tyr Asn Lys Thr Thr Lys Arg Leu Thr Ile Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ser Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Arg Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asn Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  8
<211>  751
<212>  PRT
<213>  Influenza A virus

<400>  8

Ile Lys Glu Leu Trp Asp Leu Met Ser Gln Ser Arg Thr Arg Glu Ile 
1               5                   10                  15      


Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys Lys Tyr Thr 
            20                  25                  30          


Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys Trp Met Met 
        35                  40                  45              


Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Met Glu Met Ile 
    50                  55                  60                  


Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys Thr Asn Asp 
65                  70                  75                  80  


Ala Gly Ser Asp Arg Val Met Glu Ser Pro Leu Ala Val Thr Trp Trp 
                85                  90                  95      


Asn Arg Asn Gly Pro Thr Thr Ser Thr Val His Tyr Pro Lys Val Tyr 
            100                 105                 110         


Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly Thr Phe Gly 
        115                 120                 125             


Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg Val Asp Met 
    130                 135                 140                 


Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln Asp Val Ile 
145                 150                 155                 160 


Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile Leu Thr Ser 
                165                 170                 175     


Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Arg Glu Glu Leu Lys Asn 
            180                 185                 190         


Cys Asn Ile Ala Pro Leu Met Val Ala Tyr Met Leu Glu Arg Glu Leu 
        195                 200                 205             


Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr Ser Ser Val 
    210                 215                 220                 


Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp Glu Gln Met 
225                 230                 235                 240 


Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp Gln Ser Leu 
                245                 250                 255     


Ile Ile Ala Val Gly Asn Ile Val Arg Arg Ala Thr Val Ser Ala Asp 
            260                 265                 270         


Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln Ile Gly Gly 
        275                 280                 285             


Val Arg Met Val Asp Ile Leu Lys Gln Asn Pro Thr Glu Glu Gln Ala 
    290                 295                 300                 


Val Asp Ile Cys Lys Ala Ala Met Gly Leu Lys Ile Ser Ser Ser Phe 
305                 310                 315                 320 


Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Lys Gly Ser Ser Val Lys 
                325                 330                 335     


Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu Lys Ile Lys 
            340                 345                 350         


Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg Arg Ala Thr 
        355                 360                 365             


Ala Ile Leu Arg Lys Ala Thr Arg Arg Met Ile Gln Leu Ile Val Ser 
    370                 375                 380                 


Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val Ala Met Val 
385                 390                 395                 400 


Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly Asp Leu Asn 
                405                 410                 415     


Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His Gln Leu Leu 
            420                 425                 430         


Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn Trp Gly Thr 
        435                 440                 445             


Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu Pro Asp Met 
    450                 455                 460                 


Thr Pro Ser Thr Glu Met Ser Leu Arg Gly Val Arg Val Ser Lys Met 
465                 470                 475                 480 


Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val Ser Ile Asp 
                485                 490                 495     


Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu Leu Ser Pro 
            500                 505                 510         


Glu Glu Val Ser Glu Thr Gln Gly Met Glu Lys Leu Thr Ile Thr Tyr 
        515                 520                 525             


Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser Val Leu Val 
    530                 535                 540                 


Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val Lys Ile Gln 
545                 550                 555                 560 


Trp Ser Gln Glu Pro Thr Met Leu Tyr Asn Lys Met Glu Phe Glu Pro 
                565                 570                 575     


Phe Gln Ser Leu Val Pro Lys Ala Ala Arg Ser Gln Tyr Ser Gly Phe 
            580                 585                 590         


Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly Thr Phe Asp 
        595                 600                 605             


Thr Val Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala Pro Pro Glu 
    610                 615                 620                 


Gln Ser Arg Met Gln Phe Ser Ser Leu Thr Val Asn Val Arg Gly Ser 
625                 630                 635                 640 


Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Ala Phe Asn Tyr Asn 
                645                 650                 655     


Lys Thr Thr Lys Arg Leu Thr Ile Leu Gly Lys Asp Ala Gly Ala Leu 
            660                 665                 670         


Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser Ala Val Leu 
        675                 680                 685             


Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Lys Arg Tyr Gly Pro Ala 
    690                 695                 700                 


Leu Ser Ile Asn Glu Leu Ser Asn Leu Thr Lys Gly Glu Lys Ala Asn 
705                 710                 715                 720 


Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys Arg Lys Arg 
                725                 730                 735     


Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys Arg Ile 
            740                 745                 750     


<210>  9
<211>  759
<212>  PRT
<213>  Influenza A virus

<400>  9

Met Glu Arg Ile Lys Glu Leu Arg Asp Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Met 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Thr Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Thr Thr Ser Thr Val His Tyr Pro 
            100                 105                 110         


Lys Val Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Lys Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ala Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Thr Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Lys Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Ile Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Thr Glu Met Ser Leu Arg Gly Val Arg Val 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Asn Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asp Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ala Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Val Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Val Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Leu Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Val Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Ala Leu Met Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Lys Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  10
<211>  179
<212>  PRT
<213>  Influenza A virus

<400>  10

Ser Arg Thr Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala 
1               5                   10                  15      


Ile Ile Lys Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ser Leu 
            20                  25                  30          


Arg Met Lys Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys 
        35                  40                  45              


Arg Ile Met Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu 
    50                  55                  60                  


Trp Ser Lys Thr Asn Asp Ala Gly Ser Asn Arg Val Met Val Ser Pro 
65                  70                  75                  80  


Leu Ala Val Thr Trp Trp Asn Arg Asn Gly Pro Thr Thr Ser Thr Ile 
                85                  90                  95      


His Tyr Pro Lys Val Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu 
            100                 105                 110         


Lys His Gly Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile 
        115                 120                 125             


Arg Arg Arg Val Asp Val Asn Pro Gly His Ala Asp Leu Ser Ala Lys 
    130                 135                 140                 


Glu Ala Gln Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly 
145                 150                 155                 160 


Ala Arg Ile Leu Thr Ser Glu Ser Gln Leu Ala Ile Thr Lys Glu Lys 
                165                 170                 175     


Lys Glu Glu 
            


