                         SEQUENCE LISTING

<110>  The Hamner Institutes
 
<120>  Nrf2 inhibitors and Compositions for treating mycobacterial infections

<130>  HMN20132PCT

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  605
<212>  PRT
<213>  homo sapiens

<400>  1

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Pro Ser Gln Gln Asp 
1               5                   10                  15      


Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
            20                  25                  30          


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
        35                  40                  45              


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
    50                  55                  60                  


Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
65                  70                  75                  80  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Ser Glu Thr 
                85                  90                  95      


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
            100                 105                 110         


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
        115                 120                 125             


Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
    130                 135                 140                 


Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
145                 150                 155                 160 


Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
                165                 170                 175     


Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
            180                 185                 190         


Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
        195                 200                 205             


Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
    210                 215                 220                 


Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
225                 230                 235                 240 


Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
                245                 250                 255     


Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
            260                 265                 270         


Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
        275                 280                 285             


Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
    290                 295                 300                 


Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
305                 310                 315                 320 


Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
                325                 330                 335     


Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
            340                 345                 350         


Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
        355                 360                 365             


Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
    370                 375                 380                 


Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
385                 390                 395                 400 


Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
                405                 410                 415     


Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
            420                 425                 430         


Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
        435                 440                 445             


Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
    450                 455                 460                 


His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
465                 470                 475                 480 


Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
                485                 490                 495     


Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
            500                 505                 510         


Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
        515                 520                 525             


Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
    530                 535                 540                 


Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
545                 550                 555                 560 


Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
                565                 570                 575     


Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
            580                 585                 590         


Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
        595                 600                 605 


<210>  2
<211>  589
<212>  PRT
<213>  homo sapiens

<400>  2

Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
1               5                   10                  15      


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
            20                  25                  30          


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
        35                  40                  45              


Glu Gln Glu Lys Ala Phe Phe Thr Gln Leu Gln Leu Asp Glu Glu Thr 
    50                  55                  60                  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Thr Gln Ser Glu Thr 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
                85                  90                  95      


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
            100                 105                 110         


Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
        115                 120                 125             


Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
    130                 135                 140                 


Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
145                 150                 155                 160 


Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
                165                 170                 175     


Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
            180                 185                 190         


Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
        195                 200                 205             


Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
    210                 215                 220                 


Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
225                 230                 235                 240 


Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
                245                 250                 255     


Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
            260                 265                 270         


Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
        275                 280                 285             


Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
    290                 295                 300                 


Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
305                 310                 315                 320 


Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
                325                 330                 335     


Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
            340                 345                 350         


Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
        355                 360                 365             


Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
    370                 375                 380                 


Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
385                 390                 395                 400 


Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
                405                 410                 415     


Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
            420                 425                 430         


Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
        435                 440                 445             


His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
    450                 455                 460                 


Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
465                 470                 475                 480 


Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
                485                 490                 495     


Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
            500                 505                 510         


Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
        515                 520                 525             


Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
    530                 535                 540                 


Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
545                 550                 555                 560 


Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
                565                 570                 575     


Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
            580                 585                 


<210>  3
<211>  582
<212>  PRT
<213>  homo sapiens

<400>  3

Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
1               5                   10                  15      


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
            20                  25                  30          


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
        35                  40                  45              


Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
    50                  55                  60                  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Ser Glu Thr 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
                85                  90                  95      


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
            100                 105                 110         


Phe Val Asp Asp Asn Glu Ser Leu Val Pro Asp Ile Pro Gly His Ile 
        115                 120                 125             


Glu Ser Pro Val Phe Ile Ala Thr Asn Gln Ala Gln Ser Pro Glu Thr 
    130                 135                 140                 


Ser Val Ala Gln Val Ala Pro Val Asp Leu Asp Gly Met Gln Gln Asp 
145                 150                 155                 160 


Ile Glu Gln Val Trp Glu Glu Leu Leu Ser Ile Pro Glu Leu Gln Cys 
                165                 170                 175     


Leu Asn Ile Glu Asn Asp Lys Leu Val Glu Thr Thr Met Val Pro Ser 
            180                 185                 190         


Pro Glu Ala Lys Leu Thr Glu Val Asp Asn Tyr His Phe Tyr Ser Ser 
        195                 200                 205             


Ile Pro Ser Met Glu Lys Glu Val Gly Asn Cys Ser Pro His Phe Leu 
    210                 215                 220                 


Asn Ala Phe Glu Asp Ser Phe Ser Ser Ile Leu Ser Thr Glu Asp Pro 
225                 230                 235                 240 


Asn Gln Leu Thr Val Asn Ser Leu Asn Ser Asp Ala Thr Val Asn Thr 
                245                 250                 255     


Asp Phe Gly Asp Glu Phe Tyr Ser Ala Phe Ile Ala Glu Pro Ser Ile 
            260                 265                 270         


Ser Asn Ser Met Pro Ser Pro Ala Thr Leu Ser His Ser Leu Ser Glu 
        275                 280                 285             


Leu Leu Asn Gly Pro Ile Asp Val Ser Asp Leu Ser Leu Cys Lys Ala 
    290                 295                 300                 


Phe Asn Gln Asn His Pro Glu Ser Thr Ala Glu Phe Asn Asp Ser Asp 
305                 310                 315                 320 


Ser Gly Ile Ser Leu Asn Thr Ser Pro Ser Val Ala Ser Pro Glu His 
                325                 330                 335     


Ser Val Glu Ser Ser Ser Tyr Gly Asp Thr Leu Leu Gly Leu Ser Asp 
            340                 345                 350         


Ser Glu Val Glu Glu Leu Asp Ser Ala Pro Gly Ser Val Lys Gln Asn 
        355                 360                 365             


Gly Pro Lys Thr Pro Val His Ser Ser Gly Asp Met Val Gln Pro Leu 
    370                 375                 380                 


Ser Pro Ser Gln Gly Gln Ser Thr His Val His Asp Ala Gln Cys Glu 
385                 390                 395                 400 


Asn Thr Pro Glu Lys Glu Leu Pro Val Ser Pro Gly His Arg Lys Thr 
                405                 410                 415     


Pro Phe Thr Lys Asp Lys His Ser Ser Arg Leu Glu Ala His Leu Thr 
            420                 425                 430         


Arg Asp Glu Leu Arg Ala Lys Ala Leu His Ile Pro Phe Pro Val Glu 
        435                 440                 445             


Lys Ile Ile Asn Leu Pro Val Val Asp Phe Asn Glu Met Met Ser Lys 
    450                 455                 460                 


Glu Gln Phe Asn Glu Ala Gln Leu Ala Leu Ile Arg Asp Ile Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu 
                485                 490                 495     


Glu Asn Ile Val Glu Leu Glu Gln Asp Leu Asp His Leu Lys Asp Glu 
            500                 505                 510         


Lys Glu Lys Leu Leu Lys Glu Lys Gly Glu Asn Asp Lys Ser Leu His 
        515                 520                 525             


Leu Leu Lys Lys Gln Leu Ser Thr Leu Tyr Leu Glu Val Phe Ser Met 
    530                 535                 540                 


Leu Arg Asp Glu Asp Gly Lys Pro Tyr Ser Pro Ser Glu Tyr Ser Leu 
545                 550                 555                 560 


Gln Gln Thr Arg Asp Gly Asn Val Phe Leu Val Pro Lys Ser Lys Lys 
                565                 570                 575     


Pro Asp Val Lys Lys Asn 
            580         


