                         SEQUENCE LISTING

<110>  The University of Warwick
 
<120>  Control of Uterine Contractions

<130>  N119365A-WO

<150>  GB 1312891.3
<151>  2013-07-18

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  3285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding isoform 1 of human PLC-L1

<400>  1
atggccgagg gcgcggccgg cagggaggat ccggcgccgc ccgacgcggc ggggggcgaa       60

gacgaccccc gagtgggccc ggatgccgcc ggggactgcg tgacggcggc ctctgggggc      120

cggatgaggg accgtcgcag cggggtcgca ctgccaggcg ccgcggggac cccagcggac      180

agcgaggcgg gcctcctgga ggcagcacgg gcgacccccc ggcgcagcag catcatcaag      240

gatccttcaa accaaaaatg tggtggaaga aagaaaaccg tgtctttcag cagcatgcca      300

tcggaaaaga aaattagcag tgcaaatgac tgcatcagct tcatgcaagc tggctgtgag      360

ttgaagaaag tccggccaaa ttctcgcatt tacaaccgtt ttttcactct ggacacagac      420

cttcaagctc ttcgctggga accttcaaag aaagacctcg agaaagccaa gcttgatatt      480

tctgccataa aagagatcag actggggaaa aacacggaaa catttagaaa caatggcctt      540

gctgaccaga tctgtgagga ctgtgccttt tccatactcc acggggaaaa ctatgagtct      600

ctggacctag ttgccaattc agcagatgtg gcaaacatct gggtgtctgg gttacggtac      660

ctggtttctc gaagtaagca gcctcttgat tttatggagg gcaaccagaa cacaccacgg      720

ttcatgtggt tgaaaacagt gtttgaagca gcagatgttg atgggaatgg gattatgttg      780

gaagacacct ctgtagagtt aataaaacaa ctcaacccta ctctgaagga agccaagatc      840

aggttaaagt ttaaagaaat ccagaagagc aaggaaaaac taaccacccg cgtgaccgaa      900

gaggaatttt gtgaagcttt ttgtgaactt tgcaccaggc cagaagtgta tttcttactt      960

gtacagatat ctaaaaacaa agaatatttg gatgccaatg atctcatgct ctttttagaa     1020

gctgagcaag gagtcaccca tatcaccgag gatatatgct tagacatcat aaggagatac     1080

gaactttctg aagagggacg tcaaaaaggg tttcttgcaa ttgatggctt tacccagtat     1140

ttattgtcat cagaatgtga catttttgat cctgagcaaa agaaggttgc ccaagatatg     1200

acccagccat tatctcacta ctatatcaat gcctctcata acacctatct aatagaagac     1260

cagttcaggg ggccagctga catcaatggg tacattagag ctttgaaaat gggctgtcga     1320

agcgttgaac tcgatgtaag tgatggttca gataatgaac caatcctttg taatcgaaat     1380

aacatgacaa cccatgtttc ctttcgaagt gtcatagagg taataaataa atttgccttt     1440

gttgcttctg aatacccact cattctttgc ttgggaaatc actgctcctt gccgcagcag     1500

aaggtaatgg ctcaacagat gaaaaaggtc tttggcaata aactctatac tgaagcacct     1560

ttgccctcag aatcctacct cccatcacca gaaaaattaa aaagaatgat cattgtgaaa     1620

ggaaagaagt tgccttctga tccagatgtg ttagaaggag aagtaacaga tgaagatgaa     1680

gaagctgaaa tgtctcgaag gatgtcggta gattacaatg gtgagcagaa gcaaatccga     1740

ctctgtaggg agctctctga tttggtgtct atttgtaaat ctgttcaata cagggatttt     1800

gaactatcta tgaaaagcca aaactattgg gaaatgtgtt catttagtga aacagaggcc     1860

agccgcattg caaatgagta cccagaggat tttgttaatt ataataagaa gttcttatca     1920

agaatctatc caagtgccat gaggatcgat tccagtaact tgaatccaca ggacttttgg     1980

aattgtggct gtcagattgt agcaatgaat tttcagactc cgggtccaat gatggacctt     2040

cacacgggct ggtttcttca aaacggggga tgtggttatg ttctaaggcc gtctataatg     2100

cgagatgaag tttcttactt cagcgcaaat acaaagggca ttctacctgg ggtgtctcct     2160

ctagctcttc atatcaagat catcagtggt cagaatttcc caaagcccaa gggagcttgt     2220

gccaaagggg atgtcataga tccctatgtt tgtatagaga tacacggaat tccagcggat     2280

tgttcggaac aaagaactaa aactgtacag caaaacagtg ataatcctat ttttgatgaa     2340

acttttgagt tccaagtaaa cctacctgag ctggccatga tccgttttgt tgttctggat     2400

gatgactaca ttggggatga gtttataggg caatatacga taccatttga atgtttgcag     2460

cctggatatc ggcatgttcc cctgcgttct tttgtgggtg acatcatgga gcacgtaacc     2520

ctttttgtcc acatagcaat aactaatcga agtggaggag gaaaggcaca gaagcgcagt     2580

ctttcagtga gaatggggaa gaaagttcgg gaatatacca tgctcaggaa tatcggtctt     2640

aaaaccattg atgacatctt taaaatagcg gttcatccat tacgagaagc catagatatg     2700

agagaaaata tgcagaatgc aatcgtgtct attaaggaac tatgtggact ccctccaatt     2760

gccagtctga agcagtgcct gttaactctg tcatctcggc tcatcaccag tgacaatact     2820

ccttcagtct cacttgtgat gaaagacagc tttccttacc tggagcctct gggtgcaatt     2880

ccagatgtgc agaaaaagat gctgactgct tatgatctga tgattcaaga gagccggttt     2940

ctcatagaaa tggcggacac agtccaggaa aagattgtac agtgtcagaa agcagggatg     3000

gagttccatg aagaacttca taatttgggg gcaaaagaag gcttgaaggg aagaaaactc     3060

aacaaagcaa ctgagagctt tgcttggaac attacagtat tgaagggcca aggagatctg     3120

ttgaagaatg ccaagaatga agctatagaa aacatgaagc agatccagct ggcatgcctg     3180

tcctgtggac tgagtaaagc ccccagcagc agtgctgagg ccaagagcaa gcgcagcctg     3240

gaagccatag aggagaagga aagtagtgag gagaatggga agctg                     3285


<210>  2
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA encoding isoform 2 of human PLC-L1

<400>  2
atgccatcgg aaaagaaaat tagcagtgca aatgactgca tcagcttcat gcaagctggc       60

tgtgagttga agaaagtccg gccaaattct cgcatttaca accgtttttt cactctggac      120

acagaccttc aagctcttcg ctgggaacct tcaaagaaag acctcgagaa agccaagctt      180

gatatttctg ccataaaaga gatcagactg gggaaaaaca cggaaacatt tagaaacaat      240

ggccttgctg accagatctg tgaggactgt gccttttcca tactccacgg ggaaaactat      300

gagtctctgg acctagttgc caattcagca gatgtggcaa acatctgggt gtctgggtta      360

cggtacctgg tttctcgaag taagcagcct cttgatttta tggagggcaa ccagaacaca      420

ccacggttca tgtggttgaa aacagtgttt gaagcagcag atgttgatgg gaatgggatt      480

atgttggaag acacctctgt agagttaata aaacaactca accctactct gaaggaagcc      540

aagatcaggt taaagtttaa agaaatccag aagagcaagg aaaaactaac cacccgcgtg      600

accgaagagg aattttgtga agctttttgt gaactttgca ccaggccaga agtgtatttc      660

ttacttgtac agatatctaa aaacaaagaa tatttggatg ccaatgatct catgctcttt      720

ttagaagctg agcaaggagt cacccatatc accgaggata tatgcttaga catcataagg      780

agatacgaac tttctgaaga gggacgtcaa aaagggtttc ttgcaattga tggctttacc      840

cagtatttat tgtcatcaga atgtgacatt tttgatcctg agcaaaagaa ggttgcccaa      900

gatatgaccc agccattatc tcactactat atcaatgcct ctcataacac ctatctaata      960

gaagaccagt tcagggggcc agctgacatc aatgggtaca ttagagcttt gaaaatgggc     1020

tgtcgaagcg ttgaactcga tgtaagtgat ggttcagata atgaaccaat cctttgtaat     1080

cgaaataaca tgacaaccca tgtttccttt cgaagtgtca tagaggtaat aaataaattt     1140

gcctttgttg cttctgaata cccactcatt ctttgcttgg gaaatcactg ctccttgccg     1200

cagcagaagg taatggctca acagatgaaa aaggtctttg gcaataaact ctatactgaa     1260

gcacctttgc cctcagaatc ctacctccca tcaccagaaa aattaaaaag aatgatcatt     1320

gtgaaaggaa agaagttgcc ttctgatcca gatgtgttag aaggagaagt aacagatgaa     1380

gatgaagaag ctgaaatgtc tcgaaggatg tcggtagatt acaatggtga gcagaagcaa     1440

atccgactct gtagggagct ctctgatttg gtgtctattt gtaaatctgt tcaatacagg     1500

gattttgaac tatctatgaa aagccaaaac tattgggaaa tgtgttcatt tagtgaaaca     1560

gaggccagcc gcattgcaaa tgagtaccca gaggattttg ttaattataa taagaagttc     1620

ttatcaagaa tctatccaag tgccatgagg atcgattcca gtaacttgaa tccacaggac     1680

ttttggaatt gtggctgtca gattgtagca atgaattttc agactccggg tccaatgatg     1740

gaccttcaca cgggctggtt tcttcaaaac gggggatgtg gttatgttct aaggccgtct     1800

ataatgcgag atgaagtttc ttacttcagc gcaaatacaa agggcattct acctggggtg     1860

tctcctctag ctcttcatat caagatcatc agtggtcaga atttcccaaa gcccaaggga     1920

gcttgtgcca aaggggatgt catagatccc tatgtttgta tagagataca cggaattcca     1980

gcggattgtt cggaacaaag aactaaaact gtacagcaaa acagtgataa tcctattttt     2040

gatgaaactt ttgagttcca agtaaaccta cctgagctgg ccatgatccg ttttgttgtt     2100

ctggatgatg actacattgg ggatgagttt atagggcaat atacgatacc atttgaatgt     2160

ttgcagcctg gatatcggca tgttcccctg cgttcttttg tgggtgacat catggagcac     2220

gtaacccttt ttgtccacat agcaataact aatcgaagtg gaggaggaaa ggcacagaag     2280

cgcagtcttt cagtgagaat ggggaagaaa gttcgggaat ataccatgct caggaatatc     2340

ggtcttaaaa ccattgatga catctttaaa atagcggttc atccattacg agaagccata     2400

gatatgagag aaaatatgca gaatgcaatc gtgtctatta aggaactatg tggactccct     2460

ccaattgcca gtctgaagca gtgcctgtta actctgtcat ctcggctcat caccagtgac     2520

aatactcctt cagtctcact tgtgatgaaa gacagctttc cttacctgga gcctctgggt     2580

gcaattccag atgtgcagaa aaagatgctg actgcttatg atctgatgat tcaagagagc     2640

cggtttctca tagaaatggc ggacacagtc caggaaaaga ttgtacagtg tcagaaagca     2700

gggatggagt tccatgaaga acttcataat ttgggggcaa aagaaggctt gaagggaaga     2760

aaactcaaca aagcaactga gagctttgct tggaacatta cagtattgaa gggccaagga     2820

gatctgttga agaatgccaa gaatgaagct atagaaaaca tgaagcagat ccagctggca     2880

tgcctgtcct gtggactgag taaagccccc agcagcagtg ctgaggccaa gagcaagcgc     2940

agcctggaag ccatagagga gaaggaaagt agtgaggaga atgggaagct g              2991


<210>  3
<211>  3285
<212>  RNA
<213>  Homo sapiens

<400>  3
auggccgagg gcgcggccgg cagggaggau ccggcgccgc ccgacgcggc ggggggcgaa       60

gacgaccccc gagugggccc ggaugccgcc ggggacugcg ugacggcggc cucugggggc      120

cggaugaggg accgucgcag cggggucgca cugccaggcg ccgcggggac cccagcggac      180

agcgaggcgg gccuccugga ggcagcacgg gcgacccccc ggcgcagcag caucaucaag      240

gauccuucaa accaaaaaug ugguggaaga aagaaaaccg ugucuuucag cagcaugcca      300

ucggaaaaga aaauuagcag ugcaaaugac ugcaucagcu ucaugcaagc uggcugugag      360

uugaagaaag uccggccaaa uucucgcauu uacaaccguu uuuucacucu ggacacagac      420

cuucaagcuc uucgcuggga accuucaaag aaagaccucg agaaagccaa gcuugauauu      480

ucugccauaa aagagaucag acuggggaaa aacacggaaa cauuuagaaa caauggccuu      540

gcugaccaga ucugugagga cugugccuuu uccauacucc acggggaaaa cuaugagucu      600

cuggaccuag uugccaauuc agcagaugug gcaaacaucu gggugucugg guuacgguac      660

cugguuucuc gaaguaagca gccucuugau uuuauggagg gcaaccagaa cacaccacgg      720

uucauguggu ugaaaacagu guuugaagca gcagauguug augggaaugg gauuauguug      780

gaagacaccu cuguagaguu aauaaaacaa cucaacccua cucugaagga agccaagauc      840

agguuaaagu uuaaagaaau ccagaagagc aaggaaaaac uaaccacccg cgugaccgaa      900

gaggaauuuu gugaagcuuu uugugaacuu ugcaccaggc cagaagugua uuucuuacuu      960

guacagauau cuaaaaacaa agaauauuug gaugccaaug aucucaugcu cuuuuuagaa     1020

gcugagcaag gagucaccca uaucaccgag gauauaugcu uagacaucau aaggagauac     1080

gaacuuucug aagagggacg ucaaaaaggg uuucuugcaa uugauggcuu uacccaguau     1140

uuauugucau cagaauguga cauuuuugau ccugagcaaa agaagguugc ccaagauaug     1200

acccagccau uaucucacua cuauaucaau gccucucaua acaccuaucu aauagaagac     1260

caguucaggg ggccagcuga caucaauggg uacauuagag cuuugaaaau gggcugucga     1320

agcguugaac ucgauguaag ugaugguuca gauaaugaac caauccuuug uaaucgaaau     1380

aacaugacaa cccauguuuc cuuucgaagu gucauagagg uaauaaauaa auuugccuuu     1440

guugcuucug aauacccacu cauucuuugc uugggaaauc acugcuccuu gccgcagcag     1500

aagguaaugg cucaacagau gaaaaagguc uuuggcaaua aacucuauac ugaagcaccu     1560

uugcccucag aauccuaccu cccaucacca gaaaaauuaa aaagaaugau cauugugaaa     1620

ggaaagaagu ugccuucuga uccagaugug uuagaaggag aaguaacaga ugaagaugaa     1680

gaagcugaaa ugucucgaag gaugucggua gauuacaaug gugagcagaa gcaaauccga     1740

cucuguaggg agcucucuga uuuggugucu auuuguaaau cuguucaaua cagggauuuu     1800

gaacuaucua ugaaaagcca aaacuauugg gaaauguguu cauuuaguga aacagaggcc     1860

agccgcauug caaaugagua cccagaggau uuuguuaauu auaauaagaa guucuuauca     1920

agaaucuauc caagugccau gaggaucgau uccaguaacu ugaauccaca ggacuuuugg     1980

aauuguggcu gucagauugu agcaaugaau uuucagacuc cggguccaau gauggaccuu     2040

cacacgggcu gguuucuuca aaacggggga ugugguuaug uucuaaggcc gucuauaaug     2100

cgagaugaag uuucuuacuu cagcgcaaau acaaagggca uucuaccugg ggugucuccu     2160

cuagcucuuc auaucaagau caucaguggu cagaauuucc caaagcccaa gggagcuugu     2220

gccaaagggg augucauaga ucccuauguu uguauagaga uacacggaau uccagcggau     2280

uguucggaac aaagaacuaa aacuguacag caaaacagug auaauccuau uuuugaugaa     2340

acuuuugagu uccaaguaaa ccuaccugag cuggccauga uccguuuugu uguucuggau     2400

gaugacuaca uuggggauga guuuauaggg caauauacga uaccauuuga auguuugcag     2460

ccuggauauc ggcauguucc ccugcguucu uuugugggug acaucaugga gcacguaacc     2520

cuuuuugucc acauagcaau aacuaaucga aguggaggag gaaaggcaca gaagcgcagu     2580

cuuucaguga gaauggggaa gaaaguucgg gaauauacca ugcucaggaa uaucggucuu     2640

aaaaccauug augacaucuu uaaaauagcg guucauccau uacgagaagc cauagauaug     2700

agagaaaaua ugcagaaugc aaucgugucu auuaaggaac uauguggacu cccuccaauu     2760

gccagucuga agcagugccu guuaacucug ucaucucggc ucaucaccag ugacaauacu     2820

ccuucagucu cacuugugau gaaagacagc uuuccuuacc uggagccucu gggugcaauu     2880

ccagaugugc agaaaaagau gcugacugcu uaugaucuga ugauucaaga gagccgguuu     2940

cucauagaaa uggcggacac aguccaggaa aagauuguac agugucagaa agcagggaug     3000

gaguuccaug aagaacuuca uaauuugggg gcaaaagaag gcuugaaggg aagaaaacuc     3060

aacaaagcaa cugagagcuu ugcuuggaac auuacaguau ugaagggcca aggagaucug     3120

uugaagaaug ccaagaauga agcuauagaa aacaugaagc agauccagcu ggcaugccug     3180

uccuguggac ugaguaaagc ccccagcagc agugcugagg ccaagagcaa gcgcagccug     3240

gaagccauag aggagaagga aaguagugag gagaauggga agcug                     3285


<210>  4
<211>  2991
<212>  RNA
<213>  Homo sapiens

<400>  4
augccaucgg aaaagaaaau uagcagugca aaugacugca ucagcuucau gcaagcuggc       60

ugugaguuga agaaaguccg gccaaauucu cgcauuuaca accguuuuuu cacucuggac      120

acagaccuuc aagcucuucg cugggaaccu ucaaagaaag accucgagaa agccaagcuu      180

gauauuucug ccauaaaaga gaucagacug gggaaaaaca cggaaacauu uagaaacaau      240

ggccuugcug accagaucug ugaggacugu gccuuuucca uacuccacgg ggaaaacuau      300

gagucucugg accuaguugc caauucagca gauguggcaa acaucugggu gucuggguua      360

cgguaccugg uuucucgaag uaagcagccu cuugauuuua uggagggcaa ccagaacaca      420

ccacgguuca ugugguugaa aacaguguuu gaagcagcag auguugaugg gaaugggauu      480

auguuggaag acaccucugu agaguuaaua aaacaacuca acccuacucu gaaggaagcc      540

aagaucaggu uaaaguuuaa agaaauccag aagagcaagg aaaaacuaac cacccgcgug      600

accgaagagg aauuuuguga agcuuuuugu gaacuuugca ccaggccaga aguguauuuc      660

uuacuuguac agauaucuaa aaacaaagaa uauuuggaug ccaaugaucu caugcucuuu      720

uuagaagcug agcaaggagu cacccauauc accgaggaua uaugcuuaga caucauaagg      780

agauacgaac uuucugaaga gggacgucaa aaaggguuuc uugcaauuga uggcuuuacc      840

caguauuuau ugucaucaga augugacauu uuugauccug agcaaaagaa gguugcccaa      900

gauaugaccc agccauuauc ucacuacuau aucaaugccu cucauaacac cuaucuaaua      960

gaagaccagu ucagggggcc agcugacauc aauggguaca uuagagcuuu gaaaaugggc     1020

ugucgaagcg uugaacucga uguaagugau gguucagaua augaaccaau ccuuuguaau     1080

cgaaauaaca ugacaaccca uguuuccuuu cgaaguguca uagagguaau aaauaaauuu     1140

gccuuuguug cuucugaaua cccacucauu cuuugcuugg gaaaucacug cuccuugccg     1200

cagcagaagg uaauggcuca acagaugaaa aaggucuuug gcaauaaacu cuauacugaa     1260

gcaccuuugc ccucagaauc cuaccuccca ucaccagaaa aauuaaaaag aaugaucauu     1320

gugaaaggaa agaaguugcc uucugaucca gauguguuag aaggagaagu aacagaugaa     1380

gaugaagaag cugaaauguc ucgaaggaug ucgguagauu acaaugguga gcagaagcaa     1440

auccgacucu guagggagcu cucugauuug gugucuauuu guaaaucugu ucaauacagg     1500

gauuuugaac uaucuaugaa aagccaaaac uauugggaaa uguguucauu uagugaaaca     1560

gaggccagcc gcauugcaaa ugaguaccca gaggauuuug uuaauuauaa uaagaaguuc     1620

uuaucaagaa ucuauccaag ugccaugagg aucgauucca guaacuugaa uccacaggac     1680

uuuuggaauu guggcuguca gauuguagca augaauuuuc agacuccggg uccaaugaug     1740

gaccuucaca cgggcugguu ucuucaaaac gggggaugug guuauguucu aaggccgucu     1800

auaaugcgag augaaguuuc uuacuucagc gcaaauacaa agggcauucu accuggggug     1860

ucuccucuag cucuucauau caagaucauc aguggucaga auuucccaaa gcccaaggga     1920

gcuugugcca aaggggaugu cauagauccc uauguuugua uagagauaca cggaauucca     1980

gcggauuguu cggaacaaag aacuaaaacu guacagcaaa acagugauaa uccuauuuuu     2040

gaugaaacuu uugaguucca aguaaaccua ccugagcugg ccaugauccg uuuuguuguu     2100

cuggaugaug acuacauugg ggaugaguuu auagggcaau auacgauacc auuugaaugu     2160

uugcagccug gauaucggca uguuccccug cguucuuuug ugggugacau cauggagcac     2220

guaacccuuu uuguccacau agcaauaacu aaucgaagug gaggaggaaa ggcacagaag     2280

cgcagucuuu cagugagaau ggggaagaaa guucgggaau auaccaugcu caggaauauc     2340

ggucuuaaaa ccauugauga caucuuuaaa auagcgguuc auccauuacg agaagccaua     2400

gauaugagag aaaauaugca gaaugcaauc gugucuauua aggaacuaug uggacucccu     2460

ccaauugcca gucugaagca gugccuguua acucugucau cucggcucau caccagugac     2520

aauacuccuu cagucucacu ugugaugaaa gacagcuuuc cuuaccugga gccucugggu     2580

gcaauuccag augugcagaa aaagaugcug acugcuuaug aucugaugau ucaagagagc     2640

cgguuucuca uagaaauggc ggacacaguc caggaaaaga uuguacagug ucagaaagca     2700

gggauggagu uccaugaaga acuucauaau uugggggcaa aagaaggcuu gaagggaaga     2760

aaacucaaca aagcaacuga gagcuuugcu uggaacauua caguauugaa gggccaagga     2820

gaucuguuga agaaugccaa gaaugaagcu auagaaaaca ugaagcagau ccagcuggca     2880

ugccuguccu guggacugag uaaagccccc agcagcagug cugaggccaa gagcaagcgc     2940

agccuggaag ccauagagga gaaggaaagu agugaggaga augggaagcu g              2991


<210>  5
<211>  1095
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Gly Ala Ala Gly Arg Glu Asp Pro Ala Pro Pro Asp Ala 
1               5                   10                  15      


Ala Gly Gly Glu Asp Asp Pro Arg Val Gly Pro Asp Ala Ala Gly Asp 
            20                  25                  30          


Cys Val Thr Ala Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser Gly 
        35                  40                  45              


Val Ala Leu Pro Gly Ala Ala Gly Thr Pro Ala Asp Ser Glu Ala Gly 
    50                  55                  60                  


Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Ser Ser Ile Ile Lys 
65                  70                  75                  80  


Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser Phe 
                85                  90                  95      


Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile 
            100                 105                 110         


Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser 
        115                 120                 125             


Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu 
    130                 135                 140                 


Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile 
145                 150                 155                 160 


Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Arg 
                165                 170                 175     


Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile 
            180                 185                 190         


Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala 
        195                 200                 205             


Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg 
    210                 215                 220                 


Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg 
225                 230                 235                 240 


Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn 
                245                 250                 255     


Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn 
            260                 265                 270         


Pro Thr Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln 
        275                 280                 285             


Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys 
    290                 295                 300                 


Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu 
305                 310                 315                 320 


Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met 
                325                 330                 335     


Leu Phe Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile 
            340                 345                 350         


Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln 
        355                 360                 365             


Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser 
    370                 375                 380                 


Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met 
385                 390                 395                 400 


Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr 
                405                 410                 415     


Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile 
            420                 425                 430         


Arg Ala Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp 
        435                 440                 445             


Gly Ser Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr 
    450                 455                 460                 


His Val Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe 
465                 470                 475                 480 


Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser 
                485                 490                 495     


Leu Pro Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly 
            500                 505                 510         


Asn Lys Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro 
        515                 520                 525             


Ser Pro Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu 
    530                 535                 540                 


Pro Ser Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu 
545                 550                 555                 560 


Glu Ala Glu Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln 
                565                 570                 575     


Lys Gln Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys 
            580                 585                 590         


Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn 
        595                 600                 605             


Tyr Trp Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala 
    610                 615                 620                 


Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser 
625                 630                 635                 640 


Arg Ile Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro 
                645                 650                 655     


Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln 
            660                 665                 670         


Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn 
        675                 680                 685             


Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val 
    690                 695                 700                 


Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro 
705                 710                 715                 720 


Leu Ala Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro 
                725                 730                 735     


Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile 
            740                 745                 750         


Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr 
        755                 760                 765             


Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe 
    770                 775                 780                 


Gln Val Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp 
785                 790                 795                 800 


Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe 
                805                 810                 815     


Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val 
            820                 825                 830         


Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr 
        835                 840                 845             


Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg 
    850                 855                 860                 


Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu 
865                 870                 875                 880 


Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu 
                885                 890                 895     


Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys 
            900                 905                 910         


Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu 
        915                 920                 925             


Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser 
    930                 935                 940                 


Leu Val Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile 
945                 950                 955                 960 


Pro Asp Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln 
                965                 970                 975     


Glu Ser Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile 
            980                 985                 990         


Val Gln Cys Gln Lys Ala Gly Met  Glu Phe His Glu Glu  Leu His Asn 
        995                 1000                 1005             


Leu Gly  Ala Lys Glu Gly Leu  Lys Gly Arg Lys Leu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Glu  Ser Phe Ala Trp Asn  Ile Thr Val Leu Lys  Gly Gln Gly 
    1025                 1030                 1035             


Asp Leu  Leu Lys Asn Ala Lys  Asn Glu Ala Ile Glu  Asn Met Lys 
    1040                 1045                 1050             


Gln Ile  Gln Leu Ala Cys Leu  Ser Cys Gly Leu Ser  Lys Ala Pro 
    1055                 1060                 1065             


Ser Ser  Ser Ala Glu Ala Lys  Ser Lys Arg Ser Leu  Glu Ala Ile 
    1070                 1075                 1080             


Glu Glu  Lys Glu Ser Ser Glu  Glu Asn Gly Lys Leu  
    1085                 1090                 1095 


<210>  6
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
1               5                   10                  15      


Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
            20                  25                  30          


Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
        35                  40                  45              


Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
    50                  55                  60                  


Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Arg Asn Asn 
65                  70                  75                  80  


Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                85                  90                  95      


Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
            100                 105                 110         


Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
        115                 120                 125             


Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
    130                 135                 140                 


Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
145                 150                 155                 160 


Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                165                 170                 175     


Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
            180                 185                 190         


Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
        195                 200                 205             


Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
    210                 215                 220                 


Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
225                 230                 235                 240 


Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                245                 250                 255     


Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
            260                 265                 270         


Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
        275                 280                 285             


Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
    290                 295                 300                 


Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
305                 310                 315                 320 


Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                325                 330                 335     


Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
            340                 345                 350         


Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
        355                 360                 365             


Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
    370                 375                 380                 


Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
385                 390                 395                 400 


Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                405                 410                 415     


Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
            420                 425                 430         


Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
        435                 440                 445             


Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
    450                 455                 460                 


Glu Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
465                 470                 475                 480 


Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                485                 490                 495     


Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
            500                 505                 510         


Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
        515                 520                 525             


Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
    530                 535                 540                 


Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
545                 550                 555                 560 


Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                565                 570                 575     


Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
            580                 585                 590         


Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
        595                 600                 605             


Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
    610                 615                 620                 


Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
625                 630                 635                 640 


Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                645                 650                 655     


His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
            660                 665                 670         


Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
        675                 680                 685             


Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
    690                 695                 700                 


Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
705                 710                 715                 720 


Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                725                 730                 735     


Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
            740                 745                 750         


Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
        755                 760                 765             


Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
    770                 775                 780                 


Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
785                 790                 795                 800 


Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                805                 810                 815     


Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
            820                 825                 830         


Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
        835                 840                 845             


Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
    850                 855                 860                 


Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
865                 870                 875                 880 


Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                885                 890                 895     


Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
            900                 905                 910         


Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
        915                 920                 925             


Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
    930                 935                 940                 


Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
945                 950                 955                 960 


Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                965                 970                 975     


Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
            980                 985                 990         


Glu Asn Gly Lys Leu 
        995         


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PLC-L1 siRNA

<400>  7
guagggagcu cucugauuu                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PLC-L1 siRNA

<400>  8
gaagaaaguu cgggaauau                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PLC-L1 siRNA

<400>  9
gguaauggcu caacagaug                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PLC-L1 siRNA

<400>  10
gcacagaagc gcagucuuu                                                    19


