                         SEQUENCE LISTING

<110>  Isis Innovation Ltd
 
<120>  Modulators

<130>  JA66616P.WOP

<150>  1312727.9
<151>  2013-07-16

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys 
        195             


<210>  2
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val 
            180                 185                 190 


<210>  3
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg 
            180                 185                 


<210>  4
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg 
            180                 185     


<210>  5
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 1 of human JAG 1

<400>  6

Met Gln Asn Val Asn Gly Glu Leu Gln Asn Gly Asn Cys Cys Gly Gly 
1               5                   10                  15      


Ala Arg Asn Pro Gly Asp Arg Lys Cys Thr Arg Asp Glu Cys Asp Thr 
            20                  25                  30          


Tyr 
    


<210>  7
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 1 of human DLL1

<400>  7

Phe Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly 
1               5                   10                  15      


Gly Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe 
            20                  25              


<210>  8
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 1 of human DLL3

<400>  8

Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala 
1               5                   10                  15      


Arg Leu Pro Cys Arg Leu Phe 
            20              


<210>  9
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 1 of human DLL4

<400>  9

Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg Pro Cys Glu Pro 
1               5                   10                  15      


Gly Cys Arg Thr Phe 
            20      


<210>  10
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 1 of human JAG2

<400>  10

Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala Cys Cys Asp Gly 
1               5                   10                  15      


Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His Asp Glu Cys Asp 
            20                  25                  30          


Thr Tyr 
        


<210>  11
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 3 of human JAG1

<400>  11

Trp Asp Ser Ser Asn Asp Thr Val Gln Pro Asp Ser Ile Ile 
1               5                   10                  


<210>  12
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 3 of human DLL1

<400>  12

Leu His Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg 
1               5                   10                  15      


Leu Ile 
        


<210>  13
<211>  17
<212>  PRT
<213>  Artificial seuqence

<220>
<223>  Loop 3 of human DLL3

<400>  13

Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu 
1               5                   10                  15      


Leu 
    


<210>  14
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 3 of Human DLL3

<400>  14

Trp His Ala Pro Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro Asp 
1               5                   10                  15      


Ala Leu Ile 
            


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Loop 3 of Human DLL4

<400>  15

Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu Leu Leu Ile 
1               5                   10                  15  


<210>  16
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH cDNA seuqence of JDSL31

<400>  16
gaggtgcagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctctggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggactg ggtcgcaacc attagtagtg gtggtcgtta cacctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagga caccctgtac      240

ctgcaaatga ccagtctgaa gtctgaggac acagccatgt attactgtgc aggccatgat      300

tacgggcccg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  17
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain signal peptide for JDSL31

<400>  17
ggtgtccagt gt                                                           12


<210>  18
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH protein sequence of JDSL31

<400>  18

Glu Val Gln Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Gly His Asp Tyr Gly Pro Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  19
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain signal peptide seuqence for JDSL31

<400>  19

Gly Val Gln Cys 
1               


<210>  20
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VL cDNA sequence of JDSL31

<400>  20
gagctcgtga tgacacagtc tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acatttgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  21
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL protein sequence of JDSL31

<400>  21

Glu Leu Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  22

Leu Ser Leu Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys 
1               5                   10                  15      


Gly Ala Ser Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val 
            20                  25                  30          


Asn Gly Glu Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro 
        35                  40                  45              


Gly Asp Arg Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val 
    50                  55                  60                  


Cys Leu Lys Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser 
65                  70                  75                  80  


Phe Gly Ser Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu 
                85                  90                  95      


Lys Ala Ser Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser 
            100                 105                 110         


Phe Ala Trp Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser 
        115                 120                 125             


Ser Asn Asp Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His 
    130                 135                 140                 


Ser Gly Met Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn 
145                 150                 155                 160 


Thr Gly Val Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp 
                165                 170                 175     


Tyr Tyr Tyr Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp 
            180                 185                 190         


Phe Phe Gly His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met 
        195                 200                 205             


Glu Gly Trp Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly 
    210                 215                 220                 


Cys Ser Pro Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys 
225                 230                 235                 240 


Gln Tyr Gly Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro 
                245                 250                 255     


Gly Cys Val His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu 
            260                 265                 270         


Thr Asn Trp Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly 
        275                 280                 285             


Thr His Gln Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro 
    290                 295                 300                 


Asp Lys Tyr Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys 
305                 310                 315                 320 


Glu Ile 
        


<210>  23
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys 
            340                 345     


<210>  24
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu 
                325         


<210>  25
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu 
            


<210>  26
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro 
        275         


<210>  27
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of MUNC

<400>  27

Ser Ala Lys Ile Ser Ile Thr Val Val Cys Ala Gln Gly Leu Gln Ala 
1               5                   10                  15      


Lys Asp Gly Ser Ser Asp Pro Tyr Val Thr Val Gln Val Gly Lys Thr 
            20                  25                  30          


Lys Lys Arg Thr Lys Thr Ile Tyr Gly Asn Leu Asn Pro Val Trp Glu 
        35                  40                  45              


Glu Asn Phe His Phe Glu Cys His Asn Ser Ser Asp Arg Ile Lys Val 
    50                  55                  60                  


Arg Val Leu Asp Glu Asp Asp Asp Ile Lys Glu Ser Asp Asp Phe Leu 
65                  70                  75                  80  


Gly Gln Thr Ile Ile Glu Val Arg Thr Leu Ser Gly Glu Met Asp Val 
                85                  90                  95      


Trp Tyr Asn Leu Asp Lys Arg Val Ser Gly Ala Ile Arg Leu His Ile 
            100                 105                 110         


Ser Val Glu 
        115 


<210>  28
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of human JAG1

<400>  28

Ser Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly 
1               5                   10                  15      


Glu Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp 
            20                  25                  30          


Arg Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu 
        35                  40                  45              


Lys Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly 
    50                  55                  60                  


Ser Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala 
65                  70                  75                  80  


Ser Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala 
                85                  90                  95      


Trp Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn 
            100                 105                 110         


Asp Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly 
        115                 120                 125             


Met Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly 
    130                 135                 140                 


Val Ala His Phe Glu Tyr Gln Ile Arg Val Thr 
145                 150                 155 


<210>  29
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of human JAG2

<400>  29

Met Gly Tyr Phe Glu Leu Gln Leu Ser Ala Leu Arg Asn Val Asn Gly 
1               5                   10                  15      


Glu Leu Leu Ser Gly Ala Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg 
            20                  25                  30          


Ala Gly Gly Cys Gly His Asp Glu Cys Asp Thr Tyr Val Arg Val Cys 
        35                  40                  45              


Leu Lys Glu Tyr Gln Ala Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr 
    50                  55                  60                  


Gly His Gly Ala Thr Pro Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro 
65                  70                  75                  80  


Pro Ala Gly Ala Ala Gly Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly 
                85                  90                  95      


Gly Asp Gln Asp Pro Gly Leu Val Val Ile Pro Phe Gln Phe Ala Trp 
            100                 105                 110         


Pro Arg Ser Phe Thr Leu Ile Val Glu Ala Trp Asp Trp Asp Asn Asp 
        115                 120                 125             


Thr Thr Pro Asn Glu Glu Leu Leu Ile Glu Arg Val Ser His Ala Gly 
    130                 135                 140                 


Met Ile Asn Pro Glu Asp Arg Trp Lys Ser Leu His Phe Ser Gly His 
145                 150                 155                 160 


Val Ala His Leu Glu Leu Gln Ile Arg Val Arg 
                165                 170     


<210>  30
<211>  151
<212>  PRT
<213>  Artificial seuqence

<220>
<223>  Human DLL3 fragment

<400>  30

Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu 
            20                  25                  30          


Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu 
        35                  40                  45              


Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr 
    50                  55                  60                  


Thr Glu Gln Pro Gly Ala Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly 
65                  70                  75                  80  


Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe 
                85                  90                  95      


Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro 
            100                 105                 110         


Ala Trp Ser Leu Leu Ala Arg Val Ala Gly Arg Arg Arg Leu Ala Ala 
        115                 120                 125             


Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu 
    130                 135                 140                 


Arg Phe Ser Tyr Arg Phe Val 
145                 150     


<210>  31
<211>  148
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human DLL4 fragment

<400>  31

Ser Gly Val Phe Gln Leu Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly 
1               5                   10                  15      


Val Leu Ala Ser Gly Arg Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe 
            20                  25                  30          


Arg Val Cys Leu Lys His Phe Gln Ala Val Val Ser Pro Gly Pro Cys 
        35                  40                  45              


Thr Phe Gly Thr Val Ser Thr Pro Val Leu Gly Thr Asn Ser Phe Ala 
    50                  55                  60                  


Val Arg Asp Asp Ser Ser Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro 
65                  70                  75                  80  


Phe Asn Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp 
                85                  90                  95      


His Ala Pro Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala 
            100                 105                 110         


Leu Ile Ser Lys Ile Ala Ile Gln Gly Ser Leu Ala Val Gly Gln Asn 
        115                 120                 125             


Trp Leu Leu Asp Glu Gln Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser 
    130                 135                 140                 


Tyr Arg Val Ile 
145             


<210>  32
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of human SER

<400>  32

Ala Gly Asn Phe Glu Leu Glu Ile Leu Glu Ile Leu Glu Ile Ser Asn 
1               5                   10                  15      


Thr Asn Ser His Leu Leu Asn Gly Tyr Cys Cys Gly Met Pro Ala Glu 
            20                  25                  30          


Leu Arg Ala Thr Lys Gly Cys Ser Pro Cys Thr Thr Ala Phe Arg Leu 
        35                  40                  45              


Cys Leu Lys Glu Val Gln Thr Thr Glu Gln Gly Ala Ser Ile Ser Thr 
    50                  55                  60                  


Gly Cys Ser Phe Gly Asn Ala Thr Thr Lys Ile Leu Gly Gly Ser Ser 
65                  70                  75                  80  


Phe Val Leu Ser Asp Pro Gly Val Gly Ala Ile Val Leu Pro Phe Thr 
                85                  90                  95      


Phe Arg Trp Thr Lys Ser Phe Thr Leu Ile Leu Gln Ala Leu Asp Met 
            100                 105                 110         


Tyr Asn Thr Ser Tyr Pro Asp Ala Glu Arg Leu Ile Glu Glu Thr Ser 
        115                 120                 125             


Tyr Ser Gly Val Ile Leu Pro Ser Pro Glu Trp Lys Thr Leu Asp His 
    130                 135                 140                 


Ile Gly Arg Asn Ala Arg Ile Thr Val Arg Val Arg Val Gln 
145                 150                 155             


<210>  33
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human JAG1 fragment from figure 10

<400>  33

Ser Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly 
1               5                   10                  15      


Glu Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp 
            20                  25                  30          


Arg Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu 
        35                  40                  45              


Lys Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly 
    50                  55                  60                  


Ser Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala 
65                  70                  75                  80  


Ser Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala 
                85                  90                  95      


Trp Pro Arg Ser Tyr Thr Leu Leu Val Pro Cys Ser Phe Gly Ser Gly 
            100                 105                 110         


Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser Arg 
        115                 120                 125             


Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp Pro 
    130                 135                 140                 


Arg Ser Tyr Thr Leu Leu Val Tyr Gly Phe Gly Cys Asn Lys 
145                 150                 155             


<210>  34
<211>  169
<212>  PRT
<213>  Artificial seuqence

<220>
<223>  Fragment of Human DLL1 from figure 10

<400>  34

Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe Val Asn Lys Lys Gly 
1               5                   10                  15      


Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly Ala Gly Pro Pro Pro 
            20                  25                  30          


Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His Tyr Gln Ala 
        35                  40                  45              


Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser Ala Val Thr Pro 
    50                  55                  60                  


Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp Gly Gly Gly Ala Asp 
65                  70                  75                  80  


Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe Gly Phe Thr Trp Pro 
                85                  90                  95      


Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His Thr Asp Ser Pro Asp 
            100                 105                 110         


Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile Ser Arg Leu Ala Thr 
        115                 120                 125             


Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser Gln Asp Leu His Ser 
    130                 135                 140                 


Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg Phe Val Cys Asp Glu 
145                 150                 155                 160 


His Tyr Tyr Gly Glu Gly Cys Ser Val 
                165                 


<210>  35
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human DLL fragment from figure 10

<400>  35

Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu 
            20                  25                  30          


Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu 
        35                  40                  45              


Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr 
    50                  55                  60                  


Thr Glu Gln Pro Gly Ala Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly 
65                  70                  75                  80  


Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe 
                85                  90                  95      


Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro 
            100                 105                 110         


Ala Trp Ser Leu Leu Ala Arg Val Ala Gly Arg Arg Arg Leu Ala Ala 
        115                 120                 125             


Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu 
    130                 135                 140                 


Arg Phe Ser Tyr Arg Ala Arg Cys Glu Pro Pro Ala Val Gly Thr Ala 
145                 150                 155                 160 


Cys Thr Arg 
            


<210>  36
<211>  160
<212>  PRT
<213>  Artificial seuqence

<220>
<223>  Fragment of Human DLL4 from figure 10

<400>  36

Ser Gly Val Phe Gln Leu Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly 
1               5                   10                  15      


Val Leu Ala Ser Gly Arg Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe 
            20                  25                  30          


Arg Val Cys Leu Lys His Phe Gln Ala Val Val Ser Pro Gly Pro Cys 
        35                  40                  45              


Thr Phe Gly Thr Val Ser Thr Pro Val Leu Gly Thr Asn Ser Phe Ala 
    50                  55                  60                  


Val Arg Asp Asp Ser Ser Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro 
65                  70                  75                  80  


Phe Asn Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp 
                85                  90                  95      


His Ala Pro Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala 
            100                 105                 110         


Leu Ile Ser Lys Ile Ala Ile Gln Gly Ser Leu Ala Val Gly Gln Asn 
        115                 120                 125             


Trp Leu Leu Asp Glu Gln Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser 
    130                 135                 140                 


Tyr Arg Val Ile Cys Ser Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg 
145                 150                 155                 160 


<210>  37
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of human JAG2 from figure 10

<400>  37

Met Gly Tyr Phe Glu Leu Gln Leu Ser Ala Leu Arg Asn Val Asn Gly 
1               5                   10                  15      


Glu Leu Leu Ser Gly Ala Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg 
            20                  25                  30          


Ala Gly Gly Cys Gly His Asp Glu Cys Asp Thr Tyr Val Arg Val Cys 
        35                  40                  45              


Leu Lys Glu Tyr Gln Ala Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr 
    50                  55                  60                  


Gly His Gly Ala Thr Pro Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro 
65                  70                  75                  80  


Pro Ala Gly Ala Ala Gly Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly 
                85                  90                  95      


Gly Asp Gln Asp Pro Gly Leu Val Val Ile Pro Phe Gln Phe Ala Trp 
            100                 105                 110         


Pro Arg Ser Phe Thr Leu Ile Val Glu Ala Trp Asp Trp Asp Asn Asp 
        115                 120                 125             


Thr Thr Pro Asn Glu Glu Leu Leu Ile Glu Arg Val Ser His Ala Gly 
    130                 135                 140                 


Met Ile Asn Pro Glu Asp Arg Trp Lys Ser Leu His Phe Ser Gly His 
145                 150                 155                 160 


Val Ala His Leu Glu Leu Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr 
                165                 170                 175     


Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu Leu Leu 
            180                 185                 190         


Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp Arg Trp 
        195                 200                 205             


Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu Gln Ile 
    210                 215                 220                 


Arg Val Arg Cys Asp Glu Asn Tyr 
225                 230         


<210>  38
<211>  157
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment of DLL1

<400>  38

Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe Val Asn Lys Lys Gly 
1               5                   10                  15      


Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly Ala Gly Pro Pro Pro 
            20                  25                  30          


Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His Tyr Gln Ala 
        35                  40                  45              


Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser Ala Val Thr Pro 
    50                  55                  60                  


Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp Gly Gly Gly Ala Asp 
65                  70                  75                  80  


Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe Gly Phe Thr Trp Pro 
                85                  90                  95      


Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His Thr Asp Ser Pro Asp 
            100                 105                 110         


Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile Ser Arg Leu Ala Thr 
        115                 120                 125             


Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser Gln Asp Leu His Ser 
    130                 135                 140                 


Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg Phe Val 
145                 150                 155         


