                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHOD FOR PREDICTING AND DETECTING TUMOR METASTASIS IN KIDNEY 
       CANCER

<130>  718175

<150>  US 61/844,534
<151>  2013-07-10

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2191
<212>  DNA
<213>  Homo sapiens

<400>  1
agtgcgcggg ctgacactca ttcagccggg gaaggtgagg cgagtagagg ctggtgcgga       60

acttgccgcc cccagcagcg ccggcgggct aagcccaggg ccgggcagac aaaagaggcc      120

gcccgcgtag gaaggcacgg ccggcggcgg cggagcgcag cgatggccgg gcatgaggcg      180

gcgccggcgg ctgcagcaag aggacggcat ctccttcgag taccaccgct accccgagct      240

gcgcgaggcg ctcgtgtccg tgtggctgca gtgcaccgcc atcagcagga tttacacggt      300

ggggcgcagc ttcgagggcc gggagctcct ggtcatcgag ctgtccgaca accctggcgt      360

ccatgagcct ggtgagcctg aatttaaata cattgggaat atgcatggga atgaggctgt      420

tggacgagaa ctgctcattt tcttggccca gtacctatgc aacgaatacc agaaggggaa      480

cgagacaatt gtcaacctga tccacagtac ccgcattcac atcatgcctt ccctgaaccc      540

agatggcttt gagaaggcag cgtctcagcc tggtgaactc aaggactggt ttgtgggtcg      600

aagcaatgcc cagggaatag atctgaaccg gaactttcca gacctggata ggatagtgta      660

cgtgaatgag aaagaaggtg gtccaaataa tcatctgttg aaaaatatga agaaaattgt      720

ggatcaaaac acaaagcttg ctcctgagac caaggctgtc attcattgga ttatggatat      780

tccttttgtg ctttctgcca atctccatgg aggagacctt gtggccaatt atccatatga      840

tgagacgcgg agtggtagtg ctcacgaata cagctcctcc ccagatgacg ccattttcca      900

aagcttggcc cgggcatact ctcctttcaa cccggccatg tctgacccca atcggccacc      960

atgtcgcaag aatgatgatg acagcagctt tgtagatgga accaccaacg gtggtgcttg     1020

gtacagcgta cctggaggga tgcaagactt caattacctt agcagcaact gttttgagat     1080

caccgtggag cttagctgtg agaagttccc acctgaagag actctgaaga cctactggga     1140

ggataacaaa aactccctca ttagctacct tgagcagata caccgaggag ttaaaggatt     1200

tgtccgagac cttcaaggta acccaattgc gaatgccacc atctccgtgg aaggaataga     1260

ccacgatgtt acatccgcaa aggatggtga ttactggaga ttgcttatac ctggaaacta     1320

taaacttaca gcctcagctc caggctatct ggcaataaca aagaaagtgg cagttcctta     1380

cagccctgct gctggggttg attttgaact ggagtcattt tctgaaagga aagaagagga     1440

gaaggaagaa ttgatggaat ggtggaaaat gatgtcagaa actttaaatt tttaaaaagg     1500

cttctagtta gctgctttaa atctatctat ataatgtagt atgatgtaat gtggtctttt     1560

ttttagattt tgtgcagtta atacttaaca ttgatttatt ttttaatcat ttaaatatta     1620

atcaactttc cttaaaataa atagcctctt aggtaaaaat ataagaactt gatatatttc     1680

attctcttat atagtattca ttttcctacc tatattacac aaaaaagtat agaaaagatt     1740

taagtaattt tgccatccta ggcttaaatg caatattcct ggtattattt acaatgcaga     1800

attttttgag taattctagc tttcaaaaat tagtgaagtt cttttactgt aattggtgac     1860

aatgtcacat aatgaatgct attgaaaagg ttaacagata cagctcggag ttgtgagcac     1920

tctactgcaa gacttaaata gttcagtata aattgtcgtt tttttcttgt gctgactaac     1980

tataagcatg atcttgttaa tgcatttttg atgggaagaa aaggtacatg tttacaaaga     2040

ggttttatga aaagaataaa aattgacttc ttgcttgtac atataggagc aatactatta     2100

tattatgtag tccgttaaca ctacttaaaa gtttagggtt ttctcttggt tgtagagtgg     2160

cccagaattg cattctgaat gaataaaggt t                                    2191


<210>  2
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly Ile Ser Phe Glu 
1               5                   10                  15      


Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val Ser Val Trp Leu 
            20                  25                  30          


Gln Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly Arg Ser Phe Glu 
        35                  40                  45              


Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn Pro Gly Val His 
    50                  55                  60                  


Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn Met His Gly Asn 
65                  70                  75                  80  


Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala Gln Tyr Leu Cys 
                85                  90                  95      


Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn Leu Ile His Ser 
            100                 105                 110         


Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp Gly Phe Glu Lys 
        115                 120                 125             


Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe Val Gly Arg Ser 
    130                 135                 140                 


Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro Asp Leu Asp Arg 
145                 150                 155                 160 


Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn Asn His Leu Leu 
                165                 170                 175     


Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys Leu Ala Pro Glu 
            180                 185                 190         


Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro Phe Val Leu Ser 
        195                 200                 205             


Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr Pro Tyr Asp Glu 
    210                 215                 220                 


Thr Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser Pro Asp Asp Ala 
225                 230                 235                 240 


Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe Asn Pro Ala Met 
                245                 250                 255     


Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp Asp Asp Ser Ser 
            260                 265                 270         


Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr Ser Val Pro Gly 
        275                 280                 285             


Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys Phe Glu Ile Thr 
    290                 295                 300                 


Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu Thr Leu Lys Thr 
305                 310                 315                 320 


Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr Leu Glu Gln Ile 
                325                 330                 335     


His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln Gly Asn Pro Ile 
            340                 345                 350         


Ala Asn Ala Thr Ile Ser Val Glu Gly Ile Asp His Asp Val Thr Ser 
        355                 360                 365             


Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro Gly Asn Tyr Lys 
    370                 375                 380                 


Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr Lys Lys Val Ala 
385                 390                 395                 400 


Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu Leu Glu Ser Phe 
                405                 410                 415     


Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met Glu Trp Trp Lys 
            420                 425                 430         


Met Met Ser Glu Thr Leu Asn Phe 
        435                 440 


<210>  3
<211>  1949
<212>  DNA
<213>  Mus musculus

<400>  3
gtgaggcgag aggaggctgg tgctgagctc gccaactcca cccgggcccg ggcagacaaa       60

agaggccagc aagaggacgg catctccttc gagtaccacc gctatccaga gctgcgcgag      120

gcgctggtgt ccgtatggct gcagtgcacc gccatcagca gaatctacac agtggggcgc      180

agcttcgagg gccgggagct cctggtcatc gagctgtctg acaaccccgg ggtccatgag      240

ccgggtgaac ctgaatttaa atacattggg aacatgcatg gtaatgaggc ggttggacgg      300

gaactgctta ttttcttggc ccagtacctg tgtaacgagt accagaaagg caatgagaca      360

attgtcaacc tgatccacag cacccgaatt catatcatgc cctccttgaa ccccgacggc      420

tttgagaaag ccgcatcgca gcccggcgag ctgaaggact ggtttgtggg ccgcagcaac      480

gcccagggaa tagatctgaa ccgtaacttc ccagacctgg acaggatcgt gtatgttaat      540

gagaaagaag gcggtcctaa caatcacctg ctgaagaatc tgaagaaaat tgtggaccaa      600

aattcaaagc ttgcccccga gaccaaggct gtcattcact ggatcatgga cattccattt      660

gtgctttctg ccaatctgca cggaggagac cttgtggcta attacccata tgatgagaca      720

cggagcggta ctgctcacga atacagttcc tgccctgatg acgcaatttt ccaaagcttg      780

gctcgcgcgt actcttcttt caacccagtc atgtctgacc ccaatcgacc tccctgtcgc      840

aagaatgacg atgacagcag ctttgtagat ggaacgacca atggtggtgc atggtacagc      900

gtccccggtg gaatgcaaga cttcaattac ctgagcagca actgcttcga gatcactgtg      960

gagcttagct gtgagaagtt cccaccggaa gagactctca aaagctactg ggaagataac     1020

aaaaactccc tcatcagcta cctggagcag atacaccgag gtgttaaagg gtttgtccgt     1080

gaccttcagg gtaacccgat tgccaacgca accatctctg tggacgggat agaccatgat     1140

gtcacctcgg ctaaggatgg ggattactgg cgattgcttg ctcctggaaa ctataaactt     1200

acagcctccg ctcctggcta cctggcaatc acaaagaaag tggcagttcc ttttagccct     1260

gctgttgggg tggactttga gcttgagtct ttctctgaaa ggaaggagga ggagaaggaa     1320

gaattgatgg agtggtggaa aatgatgtca gaaactttga atttttaaga aaggcttcta     1380

actaattgct ttaatctatc tatagactgt agtaagatgc aatgtggctc ttttctttta     1440

ggttgtgtgc agttgatatt taacattgat ttatttttga tcatttaagt aatagttagt     1500

aatcacgtaa atacacccgg acagaaatat aatgtctgga tctacttcat tcttacatca     1560

acattcactt taaaatctat cgaagctctt ttaacgtaat gggtgacaat gtcacatgac     1620

agatgccatg aagaagtcaa ccgatatagc ttggatctgt gaaccctgta ctgcgagaat     1680

cacatagttc catataagtt gtccttagtc tcttgtgctg attcactgta taagcatgat     1740

cctggtaatg cactttggat gggaagaaaa tgtacgtgct tttcagaggg gctctgaaca     1800

gaatgaaaac ctagttcttg cgtgtacttt gaagaatgga attgtattag tcagcctgtt     1860

aatgccactt cagagtttgg ggttttgtct tgattgtaga ttggcccaga attgcattct     1920

gatgaataaa ggcaaaaaaa aaaaaaaaa                                       1949


<210>  4
<211>  364
<212>  PRT
<213>  Mus musculus

<400>  4

Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Leu Lys Lys Ile Val Asp Gln Asn Ser Lys 
            100                 105                 110         


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
    130                 135                 140                 


Pro Tyr Asp Glu Thr Arg Ser Gly Thr Ala His Glu Tyr Ser Ser Cys 
145                 150                 155                 160 


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
                165                 170                 175     


Asn Pro Val Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
            180                 185                 190         


Asp Asp Ser Ser Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr 
        195                 200                 205             


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
    210                 215                 220                 


Phe Glu Ile Thr Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Lys Ser Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
                245                 250                 255     


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
            260                 265                 270         


Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Asp Gly Ile Asp His 
        275                 280                 285             


Asp Val Thr Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ala Pro 
    290                 295                 300                 


Gly Asn Tyr Lys Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr 
305                 310                 315                 320 


Lys Lys Val Ala Val Pro Phe Ser Pro Ala Val Gly Val Asp Phe Glu 
                325                 330                 335     


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
            340                 345                 350         


Glu Trp Trp Lys Met Met Ser Glu Thr Leu Asn Phe 
        355                 360                 


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
atggccgggc atgaggcggc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gctgcgcccc accgtgtaaa                                                   20


<210>  7
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gagcgcagcg atggccgggc atgaggcggc gccggcggc                              39


<210>  8
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
ggccctcgaa gctgcgcccc accgtgtaaa tcctgctgat                             40


<210>  9
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
cgggcatga                                                                9


<210>  10
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ccccaccgt                                                                9


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gacaaaagag gccagcaaga                                                   20


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sunthetic

<400>  12
caggttcacc cggctcat                                                     18


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
cagacaaaag aggccagcaa gaggacggca                                        30


<210>  14
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
attcaggttc acccggctca tggaccccg                                         29


<210>  15
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
aggccagcaa                                                              10


<210>  16
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gttcacccgg                                                              10


<210>  17
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
ccggccagta cctatgcaac gaatactcga gtattcgttg cataggtact ggtttttg         58


<210>  18
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ccggctccag gctatctggc aataactcga gttattgcca gatagcctgg agtttttg         58


<210>  19
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ccgggatagg atagtgtacg tgaatctcga gattcacgta cactatccta tctttttg         58


