
                                SEQUENCE LISTING

<110> ANNEXON, INC.
      ROSENTHAL, ARNON
      LEVITEN, MICHAEL

<120> ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES
  AND USES THEREOF

<130> 717192000640

<150> US 61/844,369       
<151> 2013-07-09  

<150> US 61/871,813       
<151> 2013-08-29  

<160> 26

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 245
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser
 1               5                  10                  15      
Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys
            20                  25                  30          
Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys
        35                  40                  45              
Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln
    50                  55                  60                  
Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly
65                  70                  75                  80  
Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile
                85                  90                  95      
Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln
            100                 105                 110         
Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly
        115                 120                 125             
Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr
    130                 135                 140                 
Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr
145                 150                 155                 160 
Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val
                165                 170                 175     
Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr
            180                 185                 190         
Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln
        195                 200                 205             
Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly
    210                 215                 220                 
His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu
225                 230                 235                 240 
Ile Phe Pro Ser Ala
                245 


<210> 2
<211> 253
<212> PRT
<213> Homo sapiens

<400> 2
Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu
 1               5                  10                  15      
Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr
            20                  25                  30          
Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly
        35                  40                  45              
Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu
    50                  55                  60                  
Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro
65                  70                  75                  80  
Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly
                85                  90                  95      
Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu
            100                 105                 110         
Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg
        115                 120                 125             
Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His
    130                 135                 140                 
Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe
145                 150                 155                 160 
Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser
                165                 170                 175     
Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln
            180                 185                 190         
Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr
        195                 200                 205             
Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu
    210                 215                 220                 
Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser
225                 230                 235                 240 
Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala
                245                 250             


<210> 3
<211> 245
<212> PRT
<213> Homo sapiens

<400> 3
Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys
            20                  25                  30          
Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp
        35                  40                  45              
Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala
    50                  55                  60                  
Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu
65                  70                  75                  80  
Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro
                85                  90                  95      
Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly
            100                 105                 110         
Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr
        115                 120                 125             
His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu
    130                 135                 140                 
Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys
145                 150                 155                 160 
Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala
                165                 170                 175     
Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe
            180                 185                 190         
Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu
        195                 200                 205             
Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr
    210                 215                 220                 
Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe
225                 230                 235                 240 
Leu Leu Phe Pro Asp
                245 


<210> 4
<211> 107
<212> PRT
<213> Homo sapiens

<400> 4
Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Asn Lys Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 5
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5
Arg Ala Ser Lys Ser Ile Asn Lys Tyr Leu Ala
 1               5                  10      


<210> 6
<211> 7
<212> PRT
<213> Homo sapiens

<400> 6
Ser Gly Ser Thr Leu Gln Ser
 1               5          


<210> 7
<211> 9
<212> PRT
<213> Homo sapiens

<400> 7
Gln Gln His Asn Glu Tyr Pro Leu Thr
 1               5                  


<210> 8
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ser Ser Gly Tyr His Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile His Pro Asn Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Glu Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Gly Glu Arg Asp Ser Thr Glu Val Leu Pro Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> 9
<211> 10
<212> PRT
<213> Homo sapiens

<400> 9
Gly Tyr His Phe Thr Ser Tyr Trp Met His
 1               5                  10  


<210> 10
<211> 17
<212> PRT
<213> Homo sapiens

<400> 10
Val Ile His Pro Asn Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe Glu
 1               5                  10                  15      
Ser
    


<210> 11
<211> 12
<212> PRT
<213> Homo sapiens

<400> 11
Glu Arg Asp Ser Thr Glu Val Leu Pro Met Asp Tyr
 1               5                  10          


<210> 12
<211> 321
<212> PRT
<213> Homo sapiens

<400> 12
Gly Ala Thr Gly Thr Cys Cys Ala Gly Ala Thr Ala Ala Cys Cys Cys
 1               5                  10                  15      
Ala Gly Thr Cys Thr Cys Cys Ala Thr Cys Thr Thr Ala Thr Cys Thr
            20                  25                  30          
Thr Gly Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Thr Gly Gly Ala
        35                  40                  45              
Gly Ala Ala Ala Cys Cys Ala Thr Thr Ala Cys Thr Ala Thr Thr Ala
    50                  55                  60                  
Ala Thr Thr Gly Cys Ala Gly Gly Gly Cys Ala Ala Gly Thr Ala Ala
65                  70                  75                  80  
Gly Ala Gly Cys Ala Thr Thr Ala Ala Cys Ala Ala Ala Thr Ala Thr
                85                  90                  95      
Thr Thr Ala Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Gly
            100                 105                 110         
Ala Gly Ala Ala Ala Cys Cys Thr Gly Gly Gly Ala Ala Ala Ala Cys
        115                 120                 125             
Thr Ala Ala Thr Ala Ala Gly Cys Thr Thr Cys Thr Thr Ala Thr Cys
    130                 135                 140                 
Thr Ala Cys Thr Cys Thr Gly Gly Ala Thr Cys Cys Ala Cys Thr Thr
145                 150                 155                 160 
Thr Gly Cys Ala Ala Thr Cys Thr Gly Gly Ala Ala Thr Thr Cys Cys
                165                 170                 175     
Ala Thr Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys
            180                 185                 190         
Ala Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Thr Ala Cys Ala Gly
        195                 200                 205             
Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr
    210                 215                 220                 
Cys Ala Gly Thr Ala Gly Cys Cys Thr Gly Gly Ala Gly Cys Cys Thr
225                 230                 235                 240 
Gly Ala Ala Gly Ala Thr Thr Thr Thr Gly Cys Ala Ala Thr Gly Thr
                245                 250                 255     
Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Ala Cys Ala
            260                 265                 270         
Thr Ala Ala Thr Gly Ala Ala Thr Ala Cys Cys Cys Gly Cys Thr Cys
        275                 280                 285             
Ala Cys Gly Thr Thr Cys Gly Gly Thr Gly Cys Thr Gly Gly Gly Ala
    290                 295                 300                 
Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Gly Cys Thr Gly Ala Ala
305                 310                 315                 320 
Ala
    


<210> 13
<211> 363
<212> PRT
<213> Homo sapiens

<400> 13
Cys Ala Gly Gly Thr Cys Cys Ala Ala Cys Thr Gly Cys Ala Gly Cys
 1               5                  10                  15      
Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Cys Thr
            20                  25                  30          
Gly Gly Thr Ala Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr
        35                  40                  45              
Thr Cys Ala Gly Thr Gly Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr
    50                  55                  60                  
Gly Cys Ala Ala Gly Thr Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala
65                  70                  75                  80  
Cys Cys Ala Thr Thr Thr Cys Ala Cys Cys Ala Gly Cys Thr Ala Cys
                85                  90                  95      
Thr Gly Gly Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala
            100                 105                 110         
Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala
        115                 120                 125             
Ala Gly Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Thr
    130                 135                 140                 
Gly Gly Ala Gly Thr Gly Ala Thr Thr Cys Ala Thr Cys Cys Thr Ala
145                 150                 155                 160 
Ala Thr Ala Gly Thr Gly Gly Thr Ala Gly Thr Ala Thr Thr Ala Ala
                165                 170                 175     
Cys Thr Ala Cys Ala Ala Thr Gly Ala Gly Ala Ala Gly Thr Thr Cys
            180                 185                 190         
Gly Ala Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala Cys
        195                 200                 205             
Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Ala Thr Cys
    210                 215                 220                 
Cys Thr Cys Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys
225                 230                 235                 240 
Ala Thr Gly Cys Ala Ala Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys
                245                 250                 255     
Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys
            260                 265                 270         
Gly Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr
        275                 280                 285             
Gly Cys Ala Gly Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Thr Thr
    290                 295                 300                 
Cys Thr Ala Cys Gly Gly Ala Gly Gly Thr Thr Cys Thr Cys Cys Cys
305                 310                 315                 320 
Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Thr
                325                 330                 335     
Cys Ala Ala Gly Gly Ala Ala Cys Cys Thr Cys Ala Gly Thr Cys Ala
            340                 345                 350         
Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala
        355                 360             


<210> 14
<211> 245
<212> PRT
<213> Mus musculus

<400> 14
Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Thr Met Thr
 1               5                  10                  15      
Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys
            20                  25                  30          
Asp Gly Ala Pro Gly Asn Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys
        35                  40                  45              
Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg
    50                  55                  60                  
Gly Phe Lys Gly Asp Pro Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly
65                  70                  75                  80  
Asn Val Gly Leu Pro Gly Pro Ser Gly Pro Leu Gly Asp Ser Gly Pro
                85                  90                  95      
Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln
            100                 105                 110         
Pro Arg Pro Ala Phe Ser Ala Ile Arg Gln Asn Pro Met Thr Leu Gly
        115                 120                 125             
Asn Val Val Ile Phe Asp Lys Val Leu Thr Asn Gln Glu Ser Pro Tyr
    130                 135                 140                 
Gln Asn His Thr Gly Arg Phe Ile Cys Ala Val Pro Gly Phe Tyr Tyr
145                 150                 155                 160 
Phe Asn Phe Gln Val Ile Ser Lys Trp Asp Leu Cys Leu Phe Ile Lys
                165                 170                 175     
Ser Ser Ser Gly Gly Gln Pro Arg Asp Ser Leu Ser Phe Ser Asn Thr
            180                 185                 190         
Asn Asn Lys Gly Leu Phe Gln Val Leu Ala Gly Gly Thr Val Leu Gln
        195                 200                 205             
Leu Arg Arg Gly Asp Glu Val Trp Ile Glu Lys Asp Pro Ala Lys Gly
    210                 215                 220                 
Arg Ile Tyr Gln Gly Thr Glu Ala Asp Ser Ile Phe Ser Gly Phe Leu
225                 230                 235                 240 
Ile Phe Pro Ser Ala
                245 


<210> 15
<211> 246
<212> PRT
<213> Mus musculus

<400> 15
Met Val Val Gly Pro Ser Cys Gln Pro Pro Cys Gly Leu Cys Leu Leu
 1               5                  10                  15      
Leu Leu Phe Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Ser Ala Gly
            20                  25                  30          
Cys Tyr Gly Ile Pro Gly Met Pro Gly Met Pro Gly Ala Pro Gly Lys
        35                  40                  45              
Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly Ile Pro
    50                  55                  60                  
Ala Val Pro Gly Thr Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly
65                  70                  75                  80  
Met Pro Gly His Arg Gly Lys Asn Gly Pro Arg Gly Thr Ser Gly Leu
                85                  90                  95      
Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Val Glu
            100                 105                 110         
Gly Arg Tyr Lys Gln Lys His Gln Ser Val Phe Thr Val Thr Arg Gln
        115                 120                 125             
Thr Thr Gln Tyr Pro Glu Ala Asn Ala Leu Val Arg Phe Asn Ser Val
    130                 135                 140                 
Val Thr Asn Pro Gln Gly His Tyr Asn Pro Ser Thr Gly Lys Phe Thr
145                 150                 155                 160 
Cys Glu Val Pro Gly Leu Tyr Tyr Phe Val Tyr Tyr Thr Ser His Thr
                165                 170                 175     
Ala Asn Leu Cys Val His Leu Asn Leu Asn Leu Ala Arg Val Ala Ser
            180                 185                 190         
Phe Cys Asp His Met Phe Asn Ser Lys Gln Val Ser Ser Gly Gly Val
        195                 200                 205             
Leu Leu Arg Leu Gln Arg Gly Asp Glu Val Trp Leu Ser Val Asn Asp
    210                 215                 220                 
Tyr Asn Gly Met Val Gly Ile Glu Gly Ser Asn Ser Val Phe Ser Gly
225                 230                 235                 240 
Phe Leu Leu Phe Pro Asp
                245     


<210> 16
<211> 31
<212> PRT
<213> Homo sapiens

<400> 16
Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln Leu Gln Gln
 1               5                  10                  15      
Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly His Ile
            20                  25                  30      


<210> 17
<211> 26
<212> PRT
<213> Homo sapiens

<400> 17
Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln Leu Gln Gln
 1               5                  10                  15      
Gly Asp Gln Val Trp Val Glu Lys Asp Pro
            20                  25      


<210> 18
<211> 20
<212> PRT
<213> Homo sapiens

<400> 18
Ser Gly Gly Met Val Leu Gln Leu Gln Gln Gly Asp Gln Val Trp Val
 1               5                  10                  15      
Glu Lys Asp Pro
            20  


<210> 19
<211> 18
<212> PRT
<213> Homo sapiens

<400> 19
Ser Gly Gly Met Val Leu Gln Leu Gln Gln Gly Asp Gln Val Trp Val
 1               5                  10                  15      
Glu Lys



<210> 20
<211> 23
<212> PRT
<213> Homo sapiens

<400> 20
Trp Leu Ala Val Asn Asp Tyr Tyr Asp Met Val Gly Ile Gln Gly Ser
 1               5                  10                  15      
Asp Ser Val Phe Ser Gly Phe
            20              


<210> 21
<211> 16
<212> PRT
<213> Homo sapiens

<400> 21
Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe
 1               5                  10                  15      


<210> 22
<211> 8
<212> PRT
<213> Homo sapiens

<400> 22
Tyr Asp Met Val Gly Ile Gln Gly
 1               5              


<210> 23
<211> 23
<212> PRT
<213> Homo sapiens

<400> 23
His Thr Ala Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val
 1               5                  10                  15      
Val Thr Phe Cys Gly His Thr
            20              


<210> 24
<211> 9
<212> PRT
<213> Homo sapiens

<400> 24
Arg Ser Gly Val Lys Val Val Thr Phe
 1               5                  


<210> 25
<211> 24
<212> PRT
<213> Homo sapiens

<400> 25
Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln Leu Gln Gln
 1               5                  10                  15      
Gly Asp Gln Val Trp Val Glu Lys
            20                 


<210> 26
<211> 12
<212> PRT
<213> Homo sapiens

<400> 26
Phe Gln Val Val Ser Gly Gly Met Val Leu Gln Leu
 1               5                  10          


