                         SEQUENCE LISTING

<110>  ZHANG, Fang Liang
 
<120>  Compositions and Methods for Increasing Protein Half-Life in a 
       Serum

<130>  688096-52WO

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  1

Gly Ser Gly Phe Gly Ile Asn Gly Val Ile 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  2

Gly Ser Gly Phe Gly Val Asn Gly Val Ile 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  3

Gly Asn Val Phe Thr Ile Ala Ala Met Gly 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  4

Gly Asn Val Phe Thr Ile Ala Ala Met Ala 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  5

Gly Asn Val Phe Thr Ile Asp Ala Met Gly 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  6

Gly Ser Val Phe Ser Ile Asp Ala Met Gly 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  7

Gly Asn Val Phe Gly Ile Asp Ala Val Gly 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  8

Gly Ser Ile Phe Ser Ile Lys Val Met Gly 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  9

Gly Ser Ile Phe Pro Leu Asn Asp Met Gly 
1               5                   10  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  10

Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys Gly 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  11

Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Arg Gly 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  12

Gly Ile Thr Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  13

Gly Met Thr Asn Gly Gly Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  14

Ala Met Thr Asn Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  15

Ala Thr Thr Thr Ser Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  16

Asp Ile Thr Ser Gly Gly Ser Thr Asp Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  17

Thr Ile Thr Arg Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  18

Pro Gly Val Pro 
1               


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  19

Val Thr Lys Trp Ala Ala Arg Val Gly Gly Ser Ala Glu Tyr Glu 
1               5                   10                  15  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  20

Arg Ser Lys Leu Ile Ala Thr Ile Asn Asn Pro Tyr Asp Tyr 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  21

Arg Ser Lys Leu Ile Ala Arg Ile Asn Asn Pro Tyr Glu Tyr 
1               5                   10                  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  22

Arg Pro Lys Gln Ala Thr Leu Ile Arg Asp Asp Tyr 
1               5                   10          


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  23

Asp Leu Gly Cys Ser Gly Ala Gly Ser Cys Pro Asp Tyr 
1               5                   10              


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of antibody or fragment thereof that specifically 
       binds transferrin

<400>  24

Asp Asn Arg Val Gly Gly Ser Tyr 
1               5               


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A60219 sdAb

<400>  25
caggtacagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A60219 sdAb sequence

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  27
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A60401 sdAb

<400>  27
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgaag cctctggaaa cgtcttcact atcgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgagtt agtcgcaggg attactactg gtggtagcac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg cacagaacac aatgtatctg      240

caaatgaaca gcctgagacc tgaggatacg gccgcctatt cctgtaatgc agtgacgaag      300

tgggcggccc gggttggggg aagtgccgag tatgagtact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A60401 sdAb sequence

<400>  28

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Asn Val Phe Thr Ile Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ala Tyr Ser Cys Asn 
                85                  90                  95      


Ala Val Thr Lys Trp Ala Ala Arg Val Gly Gly Ser Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  29
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13152 sdAb

<400>  29
caggtacagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag ccccgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13152 sdAb sequence

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  31
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13376 sdAb

<400>  31
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaaa cgtcttcact atcgctgcca tggcctggta ccgccaggct      120

ccagggaagg agcgcgagtt agtcgcaggg attactactg gtggtagcac aaattatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg cacagaacac gatgtatctg      240

caaatgaaca gcctgagacc tgaggatacg gccgtctatt tctgtaatgc agtgacgaag      300

tgggcggccc gggttggggg aagtgccgag tatgagtact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13376 sdAb sequence

<400>  32

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val Phe Thr Ile Ala 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Val Thr Lys Trp Ala Ala Arg Val Gly Gly Ser Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12722 sdAb

<400>  33
caggtaaagc tggaggagtc tgggggcgga ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggacccc cgtcaccgtc tcctca                                336


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12722 sdAb sequence

<400>  34

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
            100                 105                 110         


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12680 sdAb

<400>  35
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12680 sdAb sequence

<400>  36

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  37
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12690 sdAb

<400>  37
caggtacagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc ggcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12690 sdAb sequence

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  39
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13154 sdAb

<400>  39
caggtacagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgagcg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13154 sdAb sequence

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Ser Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  41
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13146 sdAb

<400>  41
gctgtacagc tggtggattc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13146 sdAb sequence

<400>  42

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  43
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13149 sdAb

<400>  43
caggtacagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13149 sdAb sequence

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  45
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12666 sdAb

<400>  45
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg gtcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12666 sdAb sequence

<400>  46

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Val Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12659 sdAb

<400>  47
gaggtgcagc tggtggagtg tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaggaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12659 sdAb sequence

<400>  48

Glu Val Gln Leu Val Glu Cys Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  49
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A13355 sdAb

<400>  49
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtgg cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattatagg      180

gagtccgtga ggggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A13355 sdAb sequence

<400>  50

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  51
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A12692 sdAb

<400>  51
gaggtgcagc tggtggagtg tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctcgggaag cggcttcggg atcaatggcg tgatctggta tcgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgctt attaagagtg acggttatac aaattataga      180

gagtccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtggctg      240

caaatgaacg ccctggaacc tgaggacaca ggcgtctatt actgtaaaac acccggagta      300

ccgtttggtc aggggaccca ggtcaccgtc tcctca                                336


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12692 sdAb sequence

<400>  52

Glu Val Gln Leu Val Glu Cys Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Gly Ile Asn 
            20                  25                  30          


Gly Val Ile Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Lys Ser Asp Gly Tyr Thr Asn Tyr Arg Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Trp Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Glu Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Thr Pro Gly Val Pro Phe Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  53
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A69476 sdAb

<400>  53
caggtaaagc tggaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaaa cgtcttcact atcgatgcca tgggctggta ccgccaggct      120

cctggaaagg agcgcgaagt cgtcgtagga atgacaaacg gtggtaaaac gaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtcgctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt attgttatgc tcgtagtaaa      300

cttatagcga ctataaacaa cccgtatgac tactggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  54
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A69476 sdAb sequence

<400>  54

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val Phe Thr Ile Asp 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Val Gly Met Thr Asn Gly Gly Lys Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Arg Ser Lys Leu Ile Ala Thr Ile Asn Asn Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  55
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A69449 sdAb

<400>  55
caggtacagc tggtggagtc tgggggaggc gtggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag cctccggaag cgtcttcagt atcgacgcca tgggctggta ccgccaggct      120

ccagggaacc agcgcgagtt ggtcgcggct atgactaatg ctggtagcac aaattatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccgagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtaatgc gcgttctaaa      300

cttatagcgc gcatcaacaa cccgtatgaa tactggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  56
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A69449 sdAb sequence

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Val Phe Ser Ile Asp 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Met Thr Asn Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Ser Lys Leu Ile Ala Arg Ile Asn Asn Pro Tyr Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  57
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A69433 sdAb

<400>  57
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggcgggtc tctgagactc       60

tcctgtgtag cctctggaaa cgtcttcggt atcgatgccg tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagct actactacta gcggtagtag cacaaactat      180

gcagactccg tgaagggccg attcaccatc tccagggaca tcgccaagaa cacggtgtat      240

ctgcaaatgg acagcctgaa acctgaggac acagccgtct attattgtta tgcccgccct      300

aagcaagcga ctctgattcg ggatgattac tggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  58
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A69433 sdAb sequence

<400>  58

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asn Val Phe Gly Ile Asp 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Thr Thr Thr Ser Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Pro Lys Gln Ala Thr Leu Ile Arg Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A69441 sdAb

<400>  59
caggtaaagc tggaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcagt atcaaggtca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagat attactagtg gtggtagtac agactattca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt actgtaatgc agatttgggc      300

tgctcaggcg ctgggtcctg ccctgactac tggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  60
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A69441 sdAb sequence

<400>  60

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Lys 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Thr Ser Gly Gly Ser Thr Asp Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Leu Gly Cys Ser Gly Ala Gly Ser Cys Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  61
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding A69447 sdAb

<400>  61
caggtaaagc tggaggagtc tgggggaggc tcggtgcagg ctggggggtc tctgagactc       60

tcctgtacag gctcgggaag catcttccca ttgaatgaca tgggctggta ccgccaggct      120

cctgggaagc agcgcgagtt ggtcgctaca attactaggg gcggcactac aaattatgca      180

gactccgtga agggccgatt caccatctcc agagacagca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa agtagaggat acagccgtct attactgtaa tatggataat      300

cgagtaggtg gcagttactg gggccagggg acccaggtca ccgtctcctc a               351


<210>  62
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A69447 sdAb sequence

<400>  62

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Ser Ile Phe Pro Leu Asn 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Arg Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Met Asp Asn Arg Val Gly Gly Ser Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  63
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P441_VHHF1 forward  primer sequence

<400>  63
gcccagccgg ccatggccsm bgtrcagctg gtggaktctg gggga                       45


<210>  64
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P442_VHHF2 forward primer sequence

<400>  64
gcccagccgg ccatggccca ggtaaagctg gaggagtctg gggga                       45


<210>  65
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P759_VHHF3 forward primer sequence

<400>  65
gcccagccgg ccatggccca ggtacagctg gtggagtct                              39


<210>  66
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P444_VHHF4 forward primer sequence

<400>  66
gcccagccgg ccatggccga ggtgcagctg gtggagtgtg g                           41


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P445_CH2R  reverse primer sequence

<400>  67
cgccatcaag gtaccagttg a                                                 21


<210>  68
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P446_CH2b3R  reverse primer sequence

<400>  68
ggggtacctg tcatccacgg accagctga                                         29


<210>  69
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P440_VHHF forward primer sequence

<400>  69
catgtgtaga ctcgcggccc agccggccat ggcc                                   34


<210>  70
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P447_VHHR reverse primer sequence

<400>  70
catgtgtaga ttcctggccg gcctggcctg aggagacggt gacctg                      46


