                         SEQUENCE LISTING

<110>  IFOM Fondazione Istituto FIRC di Oncologia Molecolare
 
<120>  BIOMARKER OF PLASMINOGEN ACTIVATION SYSTEM AND/OR OF uPAR/VN 
       INTERACTION AND USES THEREOF

<130>  123602 PCT

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro Ser Leu Thr 
65                  70                  75                  80  


Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln Thr Pro Val 
                85                  90                  95      


Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly Ala Ser Lys 
            100                 105                 110         


Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro Gly Arg Pro 
        115                 120                 125             


Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro Phe Asp Ala 
    130                 135                 140                 


Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg Gly Gln Tyr 
145                 150                 155                 160 


Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr Pro Lys Leu 
                165                 170                 175     


Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala Ala Phe Thr 
            180                 185                 190         


Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly Ser Gln Tyr 
        195                 200                 205             


Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro Arg Asn Ile 
    210                 215                 220                 


Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr Phe Phe Lys 
                245                 250                 255     


Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro Ser Gln Glu 
            260                 265                 270         


Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His Phe Ala Met 
        275                 280                 285             


Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu Phe Trp Gly 
    290                 295                 300                 


Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser Arg Asp Trp 
305                 310                 315                 320 


His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly Arg Ile Tyr 
                325                 330                 335     


Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys Gln Arg Phe 
            340                 345                 350         


Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly His Ser Arg 
        355                 360                 365             


Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr Trp Leu Ser 
    370                 375                 380                 


Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn Tyr Asp Asp 
385                 390                 395                 400 


Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro Ile Gln Ser 
                405                 410                 415     


Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn Leu Arg Thr 
            420                 425                 430         


Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser Ile Ala Gln 
        435                 440                 445             


Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
    450                 455                 


<210>  2
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys Ser Cys 
65                  70                  75                  80  


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                85                  90                  95      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            100                 105                 110         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        115                 120                 125             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    130                 135                 140                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
145                 150                 155                 160 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                165                 170                 175     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            180                 185                 190         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        195                 200                 205             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
225                 230                 235                 240 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro Pro 
                245                 250                 255     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            260                 265                 270         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        275                 280                 285             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    290                 295                 300                 


Pro Gly Lys 
305         


<210>  3
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys Ser Cys 
65                  70                  75                  80  


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                85                  90                  95      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            100                 105                 110         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        115                 120                 125             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    130                 135                 140                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
145                 150                 155                 160 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                165                 170                 175     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            180                 185                 190         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        195                 200                 205             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
225                 230                 235                 240 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro Pro 
                245                 250                 255     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            260                 265                 270         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        275                 280                 285             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    290                 295                 300                 


Pro Gly Lys 
305         


<210>  4
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys Asn Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys 
65                  70                  75                  80  


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                85                  90                  95      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            100                 105                 110         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        115                 120                 125             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    130                 135                 140                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
145                 150                 155                 160 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                165                 170                 175     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            180                 185                 190         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        195                 200                 205             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
225                 230                 235                 240 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr 
                245                 250                 255     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            260                 265                 270         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        275                 280                 285             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    290                 295                 300                 


Leu Ser Pro Gly Lys 
305                 


<210>  5
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys Asn Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys 
65                  70                  75                  80  


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                85                  90                  95      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            100                 105                 110         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        115                 120                 125             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    130                 135                 140                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
145                 150                 155                 160 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                165                 170                 175     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            180                 185                 190         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        195                 200                 205             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
225                 230                 235                 240 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr 
                245                 250                 255     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            260                 265                 270         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        275                 280                 285             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    290                 295                 300                 


Leu Ser Pro Gly Lys 
305                 


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  6
gcggatccag ccctgccatg gcacccctga g                                      31


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  7
cggggtacca tggcacccct gaga                                              24


<210>  8
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  8
ctagagggca tcatcaccat caccattgag c                                      31


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  9
ggccgctcaa tggtgatggt gatgatgccc t                                      31


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  10
ccccaagtga ctcgcgcgga tgtgttcact atg                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  11
catagtgaac acatccgcgc gagtcacttg ggg                                    33


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  12
aagccccaag tgactgccgg ggatgtgttc act                                    33


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  13
agtgaacaca tccccggcag tcacttgggg ctt                                    33


<210>  14
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  14
cagcggccgc tcaatggtga tggtgatgat g                                      31


<210>  15
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  15
gtaaatgagc ggccgcgtcg agtctagagg g                                      31


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  16
ccctctagac tcgacgcggc cgctcattta                                        30


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  17
tcgagctgga agttctgttc caggggccca                                        30


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  18
agctacccgg ggaccttgtc ttgaaggtcg                                        30


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  19
cggggtacca tggcacccct gaga                                              24


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  20
ttgcggccgc tcatttaccc ggagacag                                          28


<210>  21
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  21
ggctcgagct cctcgccatc gtcata                                            26


<210>  22
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  22
ggctcgaggg cagtggaccc caatcttgtg acaaaact                               38


<210>  23
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  23
ccgcggccgc ttagtttttc tcctcgccat c                                      31


<210>  24
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  24
gcgtcgacgg tacccgccac catgggtcac ccgccgctgc tg                          42


<210>  25
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  25
gcctcgaggg gcccctggaa cagaacttcc agatccaggt ctgggtggtt acagccact        59


<210>  26
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  26
gccctcgagg cctttatcgt catcgtcata gaccgtgtac tcatc                       45


<210>  27
<211>  45
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  + (Neu5Gc)2

<400>  27

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
        35                  40                  45  


<210>  28
<211>  65
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  + (SO3H)

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  + (SO3H)

<400>  28

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys 
65  


<210>  29
<211>  78
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  + (SO3H)

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  + (SO3H)

<400>  29

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys 
65                  70                  75              


<210>  30
<211>  78
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  + two (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  + two (SO3H)

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  + two (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  + two (SO3H)

<400>  30

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Leu Glu Leu Glu Val Leu Phe Gln Gly Pro Ile Glu Pro Lys 
65                  70                  75              


<210>  31
<211>  65
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  + (SO3H)

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  + (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  + (SO3H)

<400>  31

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys 
65  


<210>  32
<211>  65
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  + two (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  + two (SO3H)

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  + two (PO3H2)

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  + two (SO3H)

<400>  32

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Ala Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys 
65  


