                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Frderung der angewandten Forschung e.V.
 
<120>  A new fusion protein to target and treat acute myloid leukemia 
       cells

<130>  140225wo

<150>  EP13175180
<151>  2013-07-04

<160>  43    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 of heavy chain of antibody structure

<400>  1

Ser Tyr Ala Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structur

<400>  2

Ala Ile Gly Val Gln Gly Asp Arg Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structure

<400>  3

Ile Ile Gln Pro Thr Gly Arg Lys Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structure

<400>  4

Thr Ile Gln Gln Tyr Gly Thr Pro Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structure

<400>  5

Thr Ile Ala Gln Lys Gly Leu Arg Thr Ala Tyr Ala Asp Ser Val His 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structure

<400>  6

Ala Ile Gln Gln Arg Gly Leu Lys Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of heavy chain of antibody structure

<400>  7

Thr Ile Gln Lys Leu Gly Arg Gln Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of heavy chain of antibody structure

<400>  8

Gly Ile Arg Ala Phe Asp Tyr 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of heavy chain of antibody structure

<400>  9

Ser Ser Tyr Met Phe Asp Tyr 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of heavy chain of antibody structure

<400>  10

Ser Tyr Pro Ser Phe Asp Tyr 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of heavy chain of antibody structure

<400>  11

Arg Leu Ser Val Phe Asp Tyr 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of heavy chain of antibody structure

<400>  12

Gly Trp Arg Arg Phe Asp Tyr 
1               5           


<210>  13
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 of light chain of antibody structure

<400>  13

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  14

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  15

Ser Ala Ser Ala Leu Gln Ser 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  16

Lys Ala Ser Leu Leu Gln Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  17

Arg Ala Ser Ile Leu Gln Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  18

Asn Ala Ser His Leu Gln Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 of light chain of antibody structure

<400>  19

Lys Ala Ser Leu Leu Gln Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  20

Gln Gln Tyr Ala Gly Ala Pro Ser Thr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  21

Gln Gln Ala Arg Arg Arg Pro Leu Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  22

Gln Gln Pro Arg Val Leu Pro Leu Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  23

Gln Gln Ala Tyr Lys Gly Pro Leu Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  24

Gln Gln Arg Gly His Asn Pro Val Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  25

Gln Gln Gly Arg Leu Pro Pro Pro Thr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 of light chain of antibody structure

<400>  26

Gln Gln Ser Gln Thr Ala Pro Leu Thr 
1               5                   


<210>  27
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  27

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Gly Val Gln Gly Asp Arg Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Gly Ile Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  28
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  28

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ile Ile Gln Pro Thr Gly Arg Lys Thr Thr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser Ser Tyr Met Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  29
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  29

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Gln Gln Tyr Gly Thr Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser Tyr Pro Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  30
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  30

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Ala Gln Lys Gly Leu Arg Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Arg Leu Ser Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  31
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  31

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Gln Gln Arg Gly Leu Lys Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Gly Trp Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  32
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  32

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Gln Lys Leu Gly Arg Gln Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser Ala Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  33
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of antibody

<400>  33

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Gln Lys Leu Gly Arg Gln Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser Ala Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  34
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Gly Ala Pro Ser 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  35
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Arg Arg Arg Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  36
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Arg Val Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  37
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Lys Gly Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  38
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Gly His Asn Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  39
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Leu Pro Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  40
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  light chain of antibody

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Gln Thr Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105                 


<210>  41
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Primer LMB3

<400>  41
caggaaacag ctatgac                                                    17


<210>  42
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Primer fdSEQ1

<400>  42
gaattttctg tatgagg                                                    17


<210>  43
<211>  614
<212>  PRT
<213>  artificial

<220>
<223>  fusion polypeptide comprising ETA

<400>  43

Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Gln Gln Arg Gly Leu Lys Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Gly Trp Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asn Ala Ser His Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Arg Gly His Asn Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ala Ala Glu Leu Ala Ser Gly Gly Pro Glu Gly Gly Ser 
                245                 250                 255     


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
            260                 265                 270         


Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys 
        275                 280                 285             


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
    290                 295                 300                 


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
305                 310                 315                 320 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
                325                 330                 335     


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
            340                 345                 350         


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val 
        355                 360                 365             


Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala 
    370                 375                 380                 


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
385                 390                 395                 400 


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
                405                 410                 415     


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
            420                 425                 430         


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
        435                 440                 445             


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
    450                 455                 460                 


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
465                 470                 475                 480 


Ala Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
                485                 490                 495     


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
            500                 505                 510         


Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
        515                 520                 525             


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
    530                 535                 540                 


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
545                 550                 555                 560 


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
                565                 570                 575     


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
            580                 585                 590         


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
        595                 600                 605             


Pro Arg Glu Asp Leu Lys 
    610                 


