                         SEQUENCE LISTING

<110>  ImmunoQure AG
 
<120>  Human anti-IFN-alpha antibodies

<130>  IM11A06/P-WO

<150>  EP13174995.4
<151>  2013-07-03

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  5D1-VH variable heavy chain (VH) sequence; 5D1: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(333)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
gaa gtg caa ctg gtg cag gcc ggc gca gag gtg aaa gcg ccc ggg gag         48
Glu Val Gln Leu Val Gln Ala Gly Ala Glu Val Lys Ala Pro Gly Glu           
1               5                   10                  15                

tct ctg agg atc tcc tgt aag gtg tct gga tac acc ttt aca agt tat         96
Ser Leu Arg Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

tgg atc agt tgg gtg cgc cag att ccc ggg aaa ggc ctg gag tgg atg        144
Trp Ile Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

gtg aaa att gat cct aga gac tct tat acc atc tac aac ccg tcc ttc        192
Val Lys Ile Asp Pro Arg Asp Ser Tyr Thr Ile Tyr Asn Pro Ser Phe           
    50                  55                  60                            

caa ggc cac gtc tcc atc tca gtt gac aag tcc atc acc act gtc tac        240
Gln Gly His Val Ser Ile Ser Val Asp Lys Ser Ile Thr Thr Val Tyr           
65                  70                  75                  80            

ctg cag tgg agc agc ctg cag gcc tcg gac acc gcc att tat tat tgt        288
Leu Gln Trp Ser Ser Leu Gln Ala Ser Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gtg aga cat tat ctt aca cag tca ttg gtg gac tac ttt gac cac tgg        336
Val Arg His Tyr Leu Thr Gln Ser Leu Val Asp Tyr Phe Asp His Trp           
            100                 105                 110                   

ggc cag gga acg ctg gtc gcc gtc tcc tct                                366
Gly Gln Gly Thr Leu Val Ala Val Ser Ser                                   
        115                 120                                           


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Gln Ala Gly Ala Glu Val Lys Ala Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Val Lys Ile Asp Pro Arg Asp Ser Tyr Thr Ile Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Ser Ile Ser Val Asp Lys Ser Ile Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Gln Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Tyr Leu Thr Gln Ser Leu Val Asp Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Ala Val Ser Ser 
        115                 120         


<210>  3
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  5D1-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  3
gac att cag atg acc cag tct cca tcc tcc ctg tct gca tct gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agt gtc acc atc act tgc cgg gca agt cag agc gta tcc aac tac         96
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr           
            20                  25                  30                    

ttc cat tgg tat cga cag aag ccc ggg aaa gcc cct gaa ctc ctg atc        144
Phe His Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile           
        35                  40                  45                        

tat tct gca tcc aat ttg caa act ggg gtc cca tca aga ttc act ggc        192
Tyr Ser Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Thr Gly           
    50                  55                  60                            

agt ggg tct ggg aca gaa tgc act ctc acc atc acc agt ctg cag cct        240
Ser Gly Ser Gly Thr Glu Cys Thr Leu Thr Ile Thr Ser Leu Gln Pro           
65                  70                  75                  80            

gat gat ttc gca act tac tac tgt caa cag act cac ggt tac ccg ttc        288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr His Gly Tyr Pro Phe           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gac gtc aga                            321
Thr Phe Gly Gln Gly Thr Lys Leu Asp Val Arg                               
            100                 105                                       


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          


Phe His Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Cys Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr His Gly Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Asp Val Arg 
            100                 105         


<210>  5
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  5D1-CH constant heavy chain (CH) sequence

<400>  5
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  6
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  7
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  5D1-CL constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (268)..(324)
<223>  not sequenced but obtained from database

<400>  7
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  9
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  13B11-VH variable heavy chain (VH) sequence; 13B11: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  9
gac gta cag ctg ttg cag tct ggg gga ggc ttg ata cag ccg ggg ggg         48
Asp Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct ggc ttt act ttt aag gac tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr           
            20                  25                  30                    

gcc atg agt tgg gtc cgc cag gct cca ggg aag ggc ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gta ata agt cgt agt ggt aat att gta gac tat gtc gac tcc gtg        192
Ser Val Ile Ser Arg Ser Gly Asn Ile Val Asp Tyr Val Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc gtc tcc aga gac aat tcc aac aac aca ctc ttt        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Asn Asn Thr Leu Phe           
65                  70                  75                  80            

ctg caa atg gac ggc ctg aga gcc gac gac acg gcc att tat tac tgt        288
Leu Gln Met Asp Gly Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ccc aag gat atg att gtc gtg gtc cct gcg ggc ttt gac tcc        336
Ala Lys Pro Lys Asp Met Ile Val Val Val Pro Ala Gly Phe Asp Ser           
            100                 105                 110                   

tgg ggc cag gga acc ctt gtc tcc gtc tcc tca                            369
Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser                               
        115                 120                                           


<210>  10
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Arg Ser Gly Asn Ile Val Asp Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Asn Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Gly Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Lys Asp Met Ile Val Val Val Pro Ala Gly Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  11
<211>  315
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)
<223>  13B11-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(285)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  11
gac atc cag atg acc cag ttt cca tcc acc ctg tct gca tct gtt gga         48
Asp Ile Gln Met Thr Gln Phe Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agc gtc acc atc act tgc cgg gcc agt cag agc att agt gcc tgg         96
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ala Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat aag ggg tct aga tta gaa aac ggg gtc cca tcg agg ttc agc ggc        192
Tyr Lys Gly Ser Arg Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc acc atc ggc agc ctg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro           
65                  70                  75                  80            

gat gat ttt gca act tat tac tgc caa caa tat aag act tgg acg ttc        288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Thr Phe           
                85                  90                  95                

ggc caa ggg acc aag gtg gaa atc aaa                                    315
Gly Gln Gly Thr Lys Val Glu Ile Lys                                       
            100                 105                                       


<210>  12
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ile Gln Met Thr Gln Phe Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ala Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Gly Ser Arg Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  13
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  13B11-CH constant heavy chain (CH) sequence

<400>  13
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  14
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  13B11-CL constant kappa chain (CL) sequence

<400>  15
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  16
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  17
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  19D11-VH variable heavy chain (VH) sequence; 19D11: IgG1, kappa

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  not sequenced but obtained from database

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<220>
<221>  misc_feature
<222>  (361)..(378)
<223>  not sequenced but obtained from database

<400>  17
gag gtg cag ctg ttg gag tct ggg gct gag gtg aag agg cct ggg tcg         48
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ser           
1               5                   10                  15                

tcg gtg agg gtc tcc tgc agg gct tct gga gac acc ttc agc agt tac         96
Ser Val Arg Val Ser Cys Arg Ala Ser Gly Asp Thr Phe Ser Ser Tyr           
            20                  25                  30                    

cct atc agt tgg gtg cga cag gcc cct gga caa ggc ctt gag tgg atg        144
Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga agg atc ctc cct gcc ctt ggt gtc aca aac tac gct cag aac ttc        192
Gly Arg Ile Leu Pro Ala Leu Gly Val Thr Asn Tyr Ala Gln Asn Phe           
    50                  55                  60                            

cgg ggc aga atc acg att acc gcg gac aag tcg ccc ctc aca gcc tac        240
Arg Gly Arg Ile Thr Ile Thr Ala Asp Lys Ser Pro Leu Thr Ala Tyr           
65                  70                  75                  80            

ttg gaa ctg agt agc ctc aga ttt gag gac acg gcc gtg tat tac tgt        288
Leu Glu Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg agt ccc agt gcg gac ata att cct tcg att ttg ggg acg acc ctc        336
Ala Ser Pro Ser Ala Asp Ile Ile Pro Ser Ile Leu Gly Thr Thr Leu           
            100                 105                 110                   

ttt gcc ttc tgg ggc cag gga agc ctg gtc acc gtc tcc tca                378
Phe Ala Phe Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  18
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Arg Ala Ser Gly Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Leu Pro Ala Leu Gly Val Thr Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Arg Gly Arg Ile Thr Ile Thr Ala Asp Lys Ser Pro Leu Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ser Ala Asp Ile Ile Pro Ser Ile Leu Gly Thr Thr Leu 
            100                 105                 110         


Phe Ala Phe Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  19
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  19D11-VL variable light chain (VL) sequence, kappa type

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  not sequenced but obtained from database

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<220>
<221>  misc_feature
<222>  (312)..(330)
<223>  not sequenced but obtained from database

<400>  19
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ctg tct ccg ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa ggg gcc acc ctc tcc tgc agg gcc agt cag aat gtt agc aga cac         96
Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Ser Arg His           
            20                  25                  30                    

tac tta acc tgg tac cag cag aaa cct ggc cag tct ccc cgg ctc ctc        144
Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt ggc tcc agc agg gcc act ggc gtc cca gac agg ttc agt        192
Ile Tyr Gly Gly Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc ggt ggg tct ggg aca gac ttc act ctc acc atc agc agg ctg gag        240
Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gac ttt gca gtg ttt tac tgc cag agc tat cat agc cca cct        288
Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Ser Tyr His Ser Pro Pro           
                85                  90                  95                

cct gtg tac act ttc ggc cag ggg acc aag gtg gag atc aaa                330
Pro Val Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                   
            100                 105                 110                   


<210>  20
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Ser Arg His 
            20                  25                  30          


Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Gly Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Ser Tyr His Ser Pro Pro 
                85                  90                  95      


Pro Val Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  21
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  25C3-VH variable heavy chain (VH) sequence; 25C3: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(333)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  21
gag atg cag ctg atg gag tct ggg gga ggt ttg gta caa ccg ggg ggg         48
Glu Met Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcc tct ggt ttc acc ttt aaa agt ttt         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Lys Ser Phe           
            20                  25                  30                    

gcg atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gct agt gtc ggc tct cag ggt ggc agc aaa tac tat gca ccc tcc gtg        192
Ala Ser Val Gly Ser Gln Gly Gly Ser Lys Tyr Tyr Ala Pro Ser Val           
    50                  55                  60                            

aag ggc cgg ttc tcc atc tcc aga gac aat tcc aac aac act ctc tat        240
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr           
65                  70                  75                  80            

gtg caa atg aac agc ctg gga gtc gag gac acg gcc ttt tat tat tgt        288
Val Gln Met Asn Ser Leu Gly Val Glu Asp Thr Ala Phe Tyr Tyr Cys           
                85                  90                  95                

gtt aaa gag acc gat gca gtg gcg acg atg gac gct ctt gac atg tgg        336
Val Lys Glu Thr Asp Ala Val Ala Thr Met Asp Ala Leu Asp Met Trp           
            100                 105                 110                   

ggc caa ggg acc ctg gtc atc gtc tct acc                                366
Gly Gln Gly Thr Leu Val Ile Val Ser Thr                                   
        115                 120                                           


<210>  22
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Met Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Lys Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Gly Ser Gln Gly Gly Ser Lys Tyr Tyr Ala Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Val Gln Met Asn Ser Leu Gly Val Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Lys Glu Thr Asp Ala Val Ala Thr Met Asp Ala Leu Asp Met Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Ile Val Ser Thr 
        115                 120         


<210>  23
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  25C3-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  23
gac atc cgg gtg acc cag tct cca tcc tcc ctg tct gca tct gtc gga         48
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agg gtc tcc atc tct tgc cag aca agt cag agt gtt aac ata tat         96
Asp Arg Val Ser Ile Ser Cys Gln Thr Ser Gln Ser Val Asn Ile Tyr           
            20                  25                  30                    

cta aat tgg tat caa cag aga cca ggg aaa ggc cct cag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Gln Leu Leu Ile           
        35                  40                  45                        

tct gct gct tcc act ttg cag agt ggg gtc cca tca agg ttc agt ggc        192
Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gac ttc atc ctc acc atc atc agt cta caa cct        240
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ile Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat tct gca tcc tac tac tgt caa cag ggt tac att acc ccg tac        288
Glu Asp Ser Ala Ser Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Pro Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Gln Thr Ser Gln Ser Val Asn Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Gln Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ile Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Ser Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  25C3-constant heavy chain (CH) sequence

<400>  25
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  26
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  27
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  25C3-constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (268)..(324)
<223>  not sequenced but obtained from database

<400>  27
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ctc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Leu           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Leu 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  29
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  26B9-VH variable heavy chain (VH) sequence; 26B9: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  29
cag ata cta ctg cag gag tcg ggc cca gga ctg gtg aag ccc acg gag         48
Gln Ile Leu Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Thr Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgt agt gtc tct ggt gac tcc atc agt gat agt         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Ser Asp Ser           
            20                  25                  30                    

agt cac tac tgg gcc tgg att cgc cag ccc cca ggg aag gga cca gag        144
Ser His Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu           
        35                  40                  45                        

tgg att ggc agt gtc tat ttt agt tcg atg acc cac tac aac ccg tcc        192
Trp Ile Gly Ser Val Tyr Phe Ser Ser Met Thr His Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aaa agt cgc gtc agc atc tcc gtt gac aag ccc aag aac cag ttc        240
Leu Lys Ser Arg Val Ser Ile Ser Val Asp Lys Pro Lys Asn Gln Phe           
65                  70                  75                  80            

tcc tta aaa gtg acc tct gtg act gtc gcc gac acg gcc aca tat tac        288
Ser Leu Lys Val Thr Ser Val Thr Val Ala Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgt gcg aga caa gcc ctt gcc cga gtc gga gcc atg aat tgg ttc gac        336
Cys Ala Arg Gln Ala Leu Ala Arg Val Gly Ala Met Asn Trp Phe Asp           
            100                 105                 110                   

ccc tgg ggc cag gga tct ctg gtc aca gtc tcc tca                        372
Pro Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  30
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Ile Leu Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Ser Asp Ser 
            20                  25                  30          


Ser His Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu 
        35                  40                  45              


Trp Ile Gly Ser Val Tyr Phe Ser Ser Met Thr His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Val Asp Lys Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Thr Ser Val Thr Val Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Ala Leu Ala Arg Val Gly Ala Met Asn Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  26B9-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  31
gac atc ata atg acc cag tct cca gac tcc ctg cct gtg tct ctg ggc         48
Asp Ile Ile Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gag ggg gtc acc atc aac tgc aag tcc agc cag agc gtc ttt ttc acc         96
Glu Gly Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Phe Thr           
            20                  25                  30                    

tcc agt aat aag agt tgt tta gct tgg tat cag cag aag cca gga aag        144
Ser Ser Asn Lys Ser Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys           
        35                  40                  45                        

tct ccc aaa ttg ctc att tac tgg gca tca acc cgc caa tcc ggg gtc        192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc aga ggc agc ggg tct ggg aca gat ttc tct ctc acc        240
Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr           
65                  70                  75                  80            

atc acc agt ctg cag gct gaa gat gtg gct gtt tat ttc tgt cag cag        288
Ile Thr Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln           
                85                  90                  95                

tgt cag aca tcc cct ccc act ttc ggc gga ggg acc agg ttg gag atc        336
Cys Gln Thr Ser Pro Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  32
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Ile Ile Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Gly Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Phe Thr 
            20                  25                  30          


Ser Ser Asn Lys Ser Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Cys Gln Thr Ser Pro Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  33
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  26B9-CH constant heavy chain (CH) sequence

<400>  33
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  34
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  26B9-CL constant kappa chain (CL) sequence

<400>  35
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  37
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  31B4-VH variable heavy chain (VH) sequence; 31B4: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  37
cag ata cag ctg cag gag tcg ggc cca gga ctg gtg agg ccc acg gag         48
Gln Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Thr Glu           
1               5                   10                  15                

acc ctg tcc ctc act tgt agt gtc tct ggt gac tcc atc agt cag agt         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Ser Gln Ser           
            20                  25                  30                    

agt cat tac tgg gcc tgg att cgc cag ccc cca ggg aag gga cca gaa        144
Ser His Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu           
        35                  40                  45                        

tgg att ggc agt gtc tat ttt agc tcg atg acc cac tac aac ccg tcc        192
Trp Ile Gly Ser Val Tyr Phe Ser Ser Met Thr His Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aca agt cgc gtc agc atc tcc att gac aag gcc atg aat aag ttc        240
Leu Thr Ser Arg Val Ser Ile Ser Ile Asp Lys Ala Met Asn Lys Phe           
65                  70                  75                  80            

tcc tta aaa gtg acc tct gtg act gtc gcc gac acg gcc aca tat tac        288
Ser Leu Lys Val Thr Ser Val Thr Val Ala Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgt gcg aga cag gcc ctt gcc cga gtc gga gcc atg aat tgg ttc gac        336
Cys Ala Arg Gln Ala Leu Ala Arg Val Gly Ala Met Asn Trp Phe Asp           
            100                 105                 110                   

ccc tgg ggc cag gga tct ctg gtc aca gtc tcc tca                        372
Pro Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  38
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Thr Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Ser Gln Ser 
            20                  25                  30          


Ser His Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu 
        35                  40                  45              


Trp Ile Gly Ser Val Tyr Phe Ser Ser Met Thr His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Thr Ser Arg Val Ser Ile Ser Ile Asp Lys Ala Met Asn Lys Phe 
65                  70                  75                  80  


Ser Leu Lys Val Thr Ser Val Thr Val Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Ala Leu Ala Arg Val Gly Ala Met Asn Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  39
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  31B4-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  39
gac atc ata atg acc cag tct cca gag tcc ctg cct gtg tct ctg ggc         48
Asp Ile Ile Met Thr Gln Ser Pro Glu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gag ggg gtc acc atc aac tgc aag tcc agc cag agc gtc ttt ttc acc         96
Glu Gly Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Phe Thr           
            20                  25                  30                    

tcc agt aat agg agt tgt tta gct tgg tat cag cag aag cca gga cag        144
Ser Ser Asn Arg Ser Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln           
        35                  40                  45                        

tct ccc aaa ttg ctc att tac tgg gca tca acc cgc caa tcc ggg gtc        192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc aca ggc agc ggg tct ggg aca gat ttc tct ctc acc        240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr           
65                  70                  75                  80            

atc gcc ggt ctg cag gtt gaa gat gtg gct gtt tat ttc tgt cag cag        288
Ile Ala Gly Leu Gln Val Glu Asp Val Ala Val Tyr Phe Cys Gln Gln           
                85                  90                  95                

tgt cac gca tcc cct ccc act ttc ggc ggc ggg acc agg ttg gag ctc        336
Cys His Ala Ser Pro Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Leu           
            100                 105                 110                   

aga                                                                    339
Arg                                                                       
                                                                          


<210>  40
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ile Ile Met Thr Gln Ser Pro Glu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Gly Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Phe Thr 
            20                  25                  30          


Ser Ser Asn Arg Ser Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
65                  70                  75                  80  


Ile Ala Gly Leu Gln Val Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Cys His Ala Ser Pro Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Leu 
            100                 105                 110         


Arg 
    


<210>  41
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  31B4-CH constant heavy chain (CH) sequence

<400>  41
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  42
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  43
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  31B4-CL constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (268)..(324)
<223>  not sequenced but obtained from database

<400>  43
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  45
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA1F for amplification of a 
       fragment encoding aa 24-189 of IFNA1

<400>  45
tttggatcct atgtgatctc cctgagaccc acagcctgga                             40


<210>  46
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA1R for amplification of a 
       fragment encoding aa 24-189 of IFNA1

<400>  46
tttgcggccg cgaccagatg ttattccttc ctccttaatc tttc                        44


<210>  47
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA2F for amplification of a 
       fragment encoding aa 24-188 of IFNA2

<400>  47
tttgggatcc tctgtgatct gcctcaaacc caca                                   34


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA2R for amplification of a 
       fragment encoding aa 24-188 of IFNA2

<400>  48
tttgcggccg cttacttctt aaactttctt gca                                    33


<210>  49
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA4F for amplification of a 
       fragment encoding aa 24-189 of IFNA4

<400>  49
tttggatcct atgtgatctg cctcagaccc acagcctgg                              39


<210>  50
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA4R for amplification of a 
       fragment encoding aa 24-189 of IFNA4 and for amplification of a 
       fragment encoding aa 24-189 of IFNA10

<400>  50
tttgcggccg ctcaatcctt cctccttaat cttttttgca agtttgttga aaac             54


<210>  51
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA5F for amplification of a 
       fragment encoding aa 22-189 of IFNA5

<400>  51
tttggatcct actgggctgt gatctgcctc agacccacag cctgag                      46


<210>  52
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA5R for amplification of a 
       fragment encoding aa 22-189 of IFNA5

<400>  52
tttgcggccg ctcattcctt cctccttaat ctttcttgca agtttgc                     47


<210>  53
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA6F for amplification of a 
       fragment encoding aa 21-189 of IFNA6

<400>  53
tttggatcct atctctggac tgtgatctgc ctcagaccca cagcctgggt c                51


<210>  54
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA6R for amplification of a 
       fragment encoding aa 21-189 of IFNA6

<400>  54
tttgcggccg cttattcctt cctccttaac ctttcttgca agtttc                      46


<210>  55
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA7F for amplification of a 
       fragment encoding aa 24-189 of IFNA7

<400>  55
tttggatcct atgtgatctg cctcagaccc acagcctgc                              39


<210>  56
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA7R for amplification of a 
       fragment encoding aa 24-189 of IFNA7

<400>  56
tttgcggccg cgaaccagtt ttcaatcctt cctccttaat cctttttt                    48


<210>  57
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA8F for amplification of a 
       fragment encoding aa 23-189 of IFNA8

<400>  57
tttgggatcc tctgtgatct gcctcagact caca                                   34


<210>  58
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA8R for amplification of a 
       fragment encoding aa 23-189 of IFNA8

<400>  58
tttgcggccg ctcattcctt actcttcaat ctt                                    33


<210>  59
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA17F for amplification of a 
       fragment encoding aa 24-189 of IFNA10 and for amplification of a 
       fragment encoding aa 24-189 of IFNA17

<400>  59
tttggatcct atgtgatctg cctcagaccc acagcctggg                             40


<210>  60
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA14F for amplification of a 
       fragment encoding aa 24-189 of IFNA14

<400>  60
tttggatcct atgtaatctg tctcaaaccc acagcctgaa                             40


<210>  61
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA14R for amplification of a 
       fragment encoding aa 24-189 of IFNA14

<400>  61
tttgcggccg ctcaatcctt cctccttaat cttttttgca agtttgt                     47


<210>  62
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA16F for amplification of a 
       fragment encoding aa 24-189 of IFNA16

<400>  62
tttggatcct atgtgatctg cctcagact                                         29


<210>  63
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA16R for amplification of a 
       fragment encoding aa 24-189 of IFNA16

<400>  63
tttgcggccg ctcaatcctt ccttcttaat cc                                     32


<210>  64
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA17R for amplification of a 
       fragment encoding aa 24-189 of IFNA17

<400>  64
tttgcggccg cgttgaacca gttttcaatc cttcctcctt aata                        44


<210>  65
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNA21F for amplification of a 
       fragment encoding aa 24-189 of IFNA21

<400>  65
tttggatcct atgtgatctg cctcagaccc acagcct                                37


<210>  66
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNA21R for amplification of a 
       fragment encoding aa 24-189 of IFNA21

<400>  66
tttgcggccg ctcattcctt cctccttaat ctttcttgaa aaa                         43


<210>  67
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNB1F for amplification of a 
       fragment encoding aa 22-187 of IFN-Beta 1

<400>  67
tttggatcct aatgagctac aacttgcttg gattcctac                              39


<210>  68
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNB1R for amplification of a 
       fragment encoding aa 22-187 of IFN-Beta 1

<400>  68
tttgcggccg ctcagtttcg gaggtaacct gtaagtct                               38


<210>  69
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer IFNGF for amplification of a 
       fragment encoding aa 24-166 of IFN-Gamma

<400>  69
tttggatcct acaggaccca tatgtaaaag aagcagaaaa c                           41


<210>  70
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer IFNGR for amplification of a 
       fragment encoding aa 24-166 of IFN-Gamma

<400>  70
tttgcggccg cccattactg ggatgctctt cgacct                                 36


<210>  71
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  19D11-CH constant heavy chain (CH) sequence

<220>
<221>  Unsure
<222>  (1)..(35)
<223>  not sequenced but obtained from database

<220>
<221>  misc_feature
<222>  (966)..(966)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (968)..(968)
<223>  n is a, c, g, or t

<400>  71
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aan anc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Xaa Xaa Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  72
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (322)..(322)
<223>  The 'Xaa' at location 322 stands for Lys, or Asn.

<220>
<221>  misc_feature
<222>  (323)..(323)
<223>  The 'Xaa' at location 323 stands for Asn, Ser, Thr, or Ile.

<400>  72

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Xaa Xaa Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  73
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  19D11-CL constant kappa chain (CL) sequence

<400>  73
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  74
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  75
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  8H1-VH variable heavy chain (VH) sequence; 8H1: kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  75
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct gga cag acc ttc acc agt gat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln Thr Phe Thr Ser Asp           
            20                  25                  30                    

gat atc aac tgg gtg cga cag gcc cct gga cag ggg cta gag tgg atg        144
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg agg aac cct aac act cag gac acg ggc tat gca cag aag ttc        192
Gly Trp Arg Asn Pro Asn Thr Gln Asp Thr Gly Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cac ggc aga ctc acc ttg acc agc aac agt tcc ata agt aca tcc tat        240
His Gly Arg Leu Thr Leu Thr Ser Asn Ser Ser Ile Ser Thr Ser Tyr           
65                  70                  75                  80            

ctg gag ttg agc ggc ctg aga tct gag gac acg gcc gtg tat tac tgt        288
Leu Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gcg ggg act tcg acc ttg acc ggc cac tac ttc gct ttg ggg        336
Ala Arg Ala Gly Thr Ser Thr Leu Thr Gly His Tyr Phe Ala Leu Gly           
            100                 105                 110                   

gtc tgg ggc cag ggg acc acg gtc atc gtc tcc tca                        372
Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser                           
        115                 120                                           


<210>  76
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gln Thr Phe Thr Ser Asp 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Arg Asn Pro Asn Thr Gln Asp Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Leu Thr Leu Thr Ser Asn Ser Ser Ile Ser Thr Ser Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Ser Thr Leu Thr Gly His Tyr Phe Ala Leu Gly 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser 
        115                 120                 


<210>  77
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  8H1-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  77
gac atc cag ctg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgt cag gcg act cag gat att agc aaa tat         96
Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Ser Lys Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gtc cct aaa ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac gaa aca tcc aat ttg gaa gta ggg gtc cca tca agg ttc agt gga        192
Tyr Glu Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca cat ttt act ctc acc atc agc agc ctg cag gct        240
Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala           
65                  70                  75                  80            

gaa gat ttt gca aca tat tac tgt caa cag tat gag aat ttc ccg ttc        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Asn Phe Pro Phe           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  78
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  78

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  79
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  8H1-CH constant heavy chain (CH) sequence

<400>  79
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa                                990
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  80
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  81
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  8H1-CL constant kappa chain (CL) sequence

<400>  81
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  82
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  82

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  83
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  12H5-VH variable heavy chain (VH) sequence; 12H5, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  83
caa gtg caa ctg ata cag tct ggg cct gag gtg aag agg cct ggg gcc         48
Gln Val Gln Leu Ile Gln Ser Gly Pro Glu Val Lys Arg Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gcg tct gaa aac acc ttc gac act cat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Glu Asn Thr Phe Asp Thr His           
            20                  25                  30                    

tat att aat tgg gtg cga cag gcc cct gga caa ggg ctt act tgg ctg        144
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Thr Trp Leu           
        35                  40                  45                        

gga tgg ctg aac cct acc act ggt aaa aca ggc ttt cca caa aag ttt        192
Gly Trp Leu Asn Pro Thr Thr Gly Lys Thr Gly Phe Pro Gln Lys Phe           
    50                  55                  60                            

aag ggc aga gtc att ctg acc agc gac acc tcc cta aat act gcc tat        240
Lys Gly Arg Val Ile Leu Thr Ser Asp Thr Ser Leu Asn Thr Ala Tyr           
65                  70                  75                  80            

atg gaa gtg agc cgc ctg aca tct gag gac acg gcc gtt tat ttc tgt        288
Met Glu Val Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcc aga gtt ttg aag ttg tct gat gag tac aac tat ggt ttc gac gtc        336
Ala Arg Val Leu Lys Leu Ser Asp Glu Tyr Asn Tyr Gly Phe Asp Val           
            100                 105                 110                   

tgg ggc caa ggg acc acg gtc atc gtc tcc tca                            369
Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser                               
        115                 120                                           


<210>  84
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Val Gln Leu Ile Gln Ser Gly Pro Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Asn Thr Phe Asp Thr His 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Thr Trp Leu 
        35                  40                  45              


Gly Trp Leu Asn Pro Thr Thr Gly Lys Thr Gly Phe Pro Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Ile Leu Thr Ser Asp Thr Ser Leu Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Leu Lys Leu Ser Asp Glu Tyr Asn Tyr Gly Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser 
        115                 120             


<210>  85
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  12H5-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  85
gac atc cag gtg acc cag tct cca tcc tcc ctg tct gca tct att ggg         48
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly           
1               5                   10                  15                

gac aga gtc acc atc acg tgc cgg gca agt cag aac att ctc acc ttt         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Leu Thr Phe           
            20                  25                  30                    

ata aat tgg tat cag cac aaa cca ggg aaa gcc cct aaa ctc ctg atc        144
Ile Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc gtt tta caa aat gaa gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Val Leu Gln Asn Glu Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc acc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro           
65                  70                  75                  80            

gac gat ttt gga act tac tac tgt cag cag act tac ctt acc cct caa        288
Asp Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Thr Tyr Leu Thr Pro Gln           
                85                  90                  95                

tgc agt ttt ggc cag ggg acc aag gtg gag atc aaa                        324
Cys Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  86
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Leu Thr Phe 
            20                  25                  30          


Ile Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Val Leu Gln Asn Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Thr Tyr Leu Thr Pro Gln 
                85                  90                  95      


Cys Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  87
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  12H5-CH constant heavy chain (CH) sequence

<400>  87
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  88
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  89
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  12H5-CL variable light chain (VL) sequence, kappa type

<400>  89
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  90
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  90

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  91
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)
<223>  50E11-VH variable heavy chain (VH) sequence; 50E1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(309)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  91
cag gtg cag ctg gtg cag tct ggg gca gag atg aag aag cct ggg tcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc aag gat ttt gga ggc acc ttc agc gtc tat         96
Ser Val Lys Val Ser Cys Lys Asp Phe Gly Gly Thr Phe Ser Val Tyr           
            20                  25                  30                    

ggt gtc aac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ggg ctc atc cct gtc att ggg cca gct aac tac gca cag aag ttc        192
Gly Gly Leu Ile Pro Val Ile Gly Pro Ala Asn Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc aga atc acc att act gcg gac gaa tcc acg agc aca gcc tat        240
Gln Gly Arg Ile Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ttg agc agc ctg aga ttt gac gac acg gcc att tat tat tgt        288
Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gtg aga gac gac aac gaa tat tgg ggc cag gga acc ctg gtc acc gtc        336
Val Arg Asp Asp Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val           
            100                 105                 110                   

tcc tcg                                                                342
Ser Ser                                                                   
                                                                          


<210>  92
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Asp Phe Gly Gly Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Ile Pro Val Ile Gly Pro Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Asp Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  93
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  50E11-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  93
gaa atg gtg ctg aca cag tct cca gcc acc ctg tct ttg tct cca gga         48
Glu Met Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgt agg gcc agt cag act gtt agc acc ttc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Thr Phe           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa cct ggc cag gtt ccc agg ctc ctc gtc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu Val           
        35                  40                  45                        

tac gat atc tcc tcc agg gcc aat ggc act cca gcc agg ttc agt ggc        192
Tyr Asp Ile Ser Ser Arg Ala Asn Gly Thr Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

ggt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gaa ctt        240
Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Leu           
65                  70                  75                  80            

gaa gat ttt gcg gtt tat tac tgt cag tgg cgt agc aac tgg cct ccc        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Trp Arg Ser Asn Trp Pro Pro           
                85                  90                  95                

tcg ctc act ttc ggc gga ggg acc agg gtg gag atc aaa                    327
Ser Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys                       
            100                 105                                       


<210>  94
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  94

Glu Met Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Thr Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu Val 
        35                  40                  45              


Tyr Asp Ile Ser Ser Arg Ala Asn Gly Thr Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Leu 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Trp Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ser Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105                 


<210>  95
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  50E11-CH constant heavy chain (CH) sequence

<400>  95
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag ggt ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  96
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  97
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  50E11-CL constant kappa chain (CL) sequence

<400>  97
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  98
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  98

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  99
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(18)
<223>  IFNA2-peptide 19 bound specifically by mAB 19D11

<400>  99

Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
1               5                   10                  15      


Tyr Gln 
        


<210>  100
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(18)
<223>  IFNA2-peptide 32 bound specifically by mAB 19D11

<400>  100

Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
1               5                   10                  15      


Glu Val 
        


<210>  101
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(18)
<223>  IFNA2-peptide 22 bound specifically by mAB 26B9

<400>  101

Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile 
1               5                   10                  15      


Gln Gly 
        


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (1)..(18)
<223>  IFNW-peptide 23 bound specifically by mAB 26B9

<400>  102

Thr Gly Leu His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln 
1               5                   10                  15      


Val Val 
        


