                         SEQUENCE LISTING

<110>  Stallergenes S.A.
 
<120>  C1q as a therapeutic agent of allergy and/or asthma

<130>  BET 14P1622

<150>  EP13305940.2
<151>  2013-07-02

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(22)

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  variant rs17887074 (E=>K)

<220>
<221>  mat_peptide
<222>  (23)..(245)

<220>
<221>  DOMAIN
<222>  (31)..(109)
<223>  collagen-like

<220>
<221>  DOMAIN
<222>  (110)..(245)
<223>  C1q

<220>
<221>  DOMAIN
<222>  (110)..(245)
<223>  C1qA globular domain

<400>  1

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
        -20                 -15                 -10             


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
    -5              -1  1               5                   10  


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
                15                  20                  25      


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
            30                  35                  40          


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
        45                  50                  55              


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
    60                  65                  70                  


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
75                  80                  85                  90  


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
                95                  100                 105     


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
            110                 115                 120         


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
        125                 130                 135             


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
    140                 145                 150                 


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
155                 160                 165                 170 


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
                175                 180                 185     


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
            190                 195                 200         


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
        205                 210                 215             


Ile Phe Pro Ser Ala 
    220             


<210>  2
<211>  253
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(27)

<220>
<221>  mat_peptide
<222>  (28)..(253)

<220>
<221>  DOMAIN
<222>  (37)..(86)
<223>  Collagen-like 1

<220>
<221>  DOMAIN
<222>  (60)..(114)
<223>  Collagen-like 2

<220>
<221>  DOMAIN
<222>  (117)..(253)
<223>  C1qB globular domain

<400>  2

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
        -25                 -20                 -15             


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
    -10                 -5              -1  1               5   


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
                10                  15                  20      


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
            25                  30                  35          


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
        40                  45                  50              


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
    55                  60                  65                  


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
70                  75                  80                  85  


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
                90                  95                  100     


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
            105                 110                 115         


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
        120                 125                 130             


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
    135                 140                 145                 


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
150                 155                 160                 165 


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
                170                 175                 180     


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
            185                 190                 195         


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
        200                 205                 210             


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
    215                 220                 225     


<210>  3
<211>  245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(28)

<220>
<221>  mat_peptide
<222>  (29)..(245)

<220>
<221>  DOMAIN
<222>  (31)..(112)
<223>  Collagen-like

<220>
<221>  DOMAIN
<222>  (115)..(245)
<223>  C1qC globular domain

<400>  3

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
            -25                 -20                 -15         


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
        -10                 -5              -1  1               


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
5                   10                  15                  20  


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
                25                  30                  35      


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
            40                  45                  50          


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
        55                  60                  65              


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
    70                  75                  80                  


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
85                  90                  95                  100 


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
                105                 110                 115     


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
            120                 125                 130         


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
        135                 140                 145             


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
    150                 155                 160                 


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
165                 170                 175                 180 


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
                185                 190                 195     


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
            200                 205                 210         


Leu Leu Phe Pro Asp 
        215         


